UA128161U - METHOD OF DIAGNOSTICS OF ATHEROSCLEROSIS DEVELOPMENT - Google Patents

Abstract

A method of diagnosing the development of atherosclerosis includes clinical examination, examination of low and high density lipoprotein cholesterol levels, arteriography. MTHFR C677T gene polymorphism, endothelin content, folic acid, CISR, PSA, IL-6, homocysteine, and homozygous carrier 677-TT, endothelin levels> 10 ng / ml, folic acid, 6 are further determined in serum. CISP <102 ng / ml, SRP> 6 mg / l, IL-6> 10 ng / l, homocysteine> 20 μmol / l diagnose the development of atherosclerosis.

Description

A useful model belongs to medicine, in particular to therapy and rheumatology. It is prescribed and can be used in the treatment and examination of patients.

Ways of diagnosing the development of atherosclerosis are known. These include determination of low- and high-density lipoprotein cholesterol levels, arteriography of TSA.N. Okorokov

Diagnosis of diseases of internal organs. - Med. Lit., 2003. - Vol. 6. - P. 75-85.

However, the known method is not effective enough and does not allow diagnosing the development of atherosclerosis at the beginning of the disease. Accordingly, there is no possibility to prevent atherosclerosis.

The basis of a useful model is the task of developing a method that would allow early diagnosis of atherosclerosis.

The task is solved by the fact that together with a clinical examination, a study of low and high-density lipoprotein cholesterol levels, arteriography, according to a useful model, the polymorphism of the methylenetetrahydrofolate reductase gene (MITNEV Сб677Т), the content of endothelin, folic acid, C-terminal propeptide is determined in the patient's blood serum type I collagen (SISR), C-reactive protein (SRP), interleukin 6 (IL-6), homocysteine. With homozygous carrier 677-TT, levels of endothelin 210 ng/ml, folic acid "6 ng/ml, SISR "102 ng/ml, SRP "b mg/l, IL-6 "10 ng/l, homocysteine 220 μmol/l diagnose the development of atherosclerosis.

Application of the method. During hospitalization, the patient is examined, low- and high-density lipoprotein cholesterol levels are examined, and arteriography is performed. In the blood serum of the patient, the MTNEV C677T gene polymorphism is determined. The content of endothelin, folic acid, SISR, SRP, IL-6, homocysteine is determined by immunoenzymatic method. With homozygous carrier 677-

TT, levels of endothelin 210 ng/ml, folic acid "6 ng/ml, SISR "102 ng/ml, SRP "6 mg/l, IL-6 210 ng/l, homocysteine 220 μmol/l diagnose the development of atherosclerosis.

A specific example of using the method.

Patient Kh., 53 years old, hospitalized in the clinic with a diagnosis of rheumatoid arthritis. Examined

Low and high density lipoprotein cholesterol levels were studied. An arteriography of vessels was performed. No signs of atherosclerosis were detected. A gene polymorphism was determined in blood serum

MTNEVK S677T. The content of endothelin, folic acid,

SISR, SRP, IL-b6, homocysteine. Homozygous carrier 677-1T was established. Levels of endothelin - 17.3 ng/ml, folic acid - 3.4 ng/ml, SICP - 78 ng/ml, SRP - 14 mg/l, IL-6-20 ng/l, homocysteine - 32 μmol/l. The development of atherosclerosis was diagnosed. Arteriographic confirmation of the diagnosis was obtained only after 13 months.

Thus, the proposed method makes it possible to establish a diagnosis at the early stages of the development of the process.

Claims (1)

USEFUL MODEL FORMULA The method of diagnosing the development of atherosclerosis, which includes a clinical examination, level research 40 low- and high-density lipoprotein cholesterol, arteriography, which is distinguished by the fact that the MTNEV C677T gene polymorphism, the content of endothelin, folic acid, SISR, SRP, IL-b, homocysteine are additionally determined in the blood serum, and in the case of homozygous 677-TT carrier, the levels endothelin 210 ng/ml, folic acid "6 ng/ml, SISR "102 ng/ml, SRP "6 mg/l, IL-6 "10 ng/l, homocysteine 220 μmol/l diagnose the development of atherosclerosis.