UA127859U - METHOD OF DIAGNOSTICS OF ATHEROSCLEROSIS DEVELOPMENT - Google Patents

Abstract

A method of diagnosing the development of atherosclerosis includes clinical examination, examination of low and high density lipoprotein cholesterol levels, arteriography. In the serum, determine the polymorphism of the gene MTHFR C677T, the content of endothelin, folic acid, CISR, SRP, homozygous carrier 677-TT, endothelin levels> 10 ng / ml, folic acid <6 ng / ml, CISP <102 ng > 6 mg / l diagnose the development of atherosclerosis.

Description

The useful model belongs to medicine, in particular to therapy and rheumatology and can be used in the treatment and examination of patients.

Ways of diagnosing the development of atherosclerosis are known. These include determination of low- and high-density lipoprotein cholesterol levels, arteriography (AN Okorokov.

Diagnosis of diseases of internal organs. - Vol. 6 - pp. 75-85).

However, the known method is not effective enough and does not allow diagnosing the development of atherosclerosis even at the onset of the disease. Accordingly, there is no possibility to prevent atherosclerosis.

The basis of a useful model is the task of developing a method that would allow diagnosing the onset of atherosclerosis at an early stage.

The task is solved by the fact that along with the study of low- and high-density lipoprotein cholesterol levels, arteriography in the patient's blood serum determines the polymorphism of the methylenetetrahydrofolate reductase gene (MTNEK C677T), the content of endothelin, folic acid, C-terminal propeptide of type I collagen (SICP), C- reactive protein (SRP).

With homozygous carrier 677-TT, levels of endothelin 210 ng/ml, folic acid "6 ng/ml,

SISR "102 ng/ml, PSA "6 mg/l diagnose the development of atherosclerosis.

Application of the method. During hospitalization, the patient is examined, low- and high-density lipoprotein cholesterol levels are examined, and arteriography is performed. The polymorphism of the MTNEK C677T gene is determined in the patient's blood serum. The content of endothelin, folic acid, SISR, SRP is determined by immunoenzymatic method. At homozygous carrier 677-TT, levels of endothelin 210 ng/ml, folic acid "6 ng/ml, SISR "102 ng/ml, SRP "6 mg/l diagnose the development of atherosclerosis.

A specific example of using the method.

Patient 0O., 44 years old, hospitalized in a ward with a diagnosis of rheumatoid arthritis. Examined

Low and high density lipoprotein cholesterol levels were studied. An arteriography of vessels was performed. No signs of atherosclerosis were detected. A gene polymorphism was determined in blood serum

MTNEK S677T. The content of endothelin, folic acid,

SISR, SRP. Homozygous carrier 677-1T was established. Levels of endothelin - 16.5 ng/ml, folic acid - 2.8 ng/ml, SISR - 88 ng/ml, PSA - 14 mg/l. The development of atherosclerosis was diagnosed.

Arteriographic confirmation of the diagnosis was obtained only after 13 months.

Thus, the proposed method makes it possible to establish a diagnosis at the early stages of the development of the process.

Claims (1)

USEFUL MODEL FORMULA The method of diagnosing the development of atherosclerosis, which includes a clinical examination, research on the levels of low and high-density lipoprotein cholesterol, arteriography, which is distinguished by the fact that in the blood serum, the polymorphism of the MTNEK C677T gene, the content of endothelin, folic acid, SISR, SRP, in the case of homozygous carrier 677- TT, levels of endothelin 210 ng/ml, folic acid "6 ng/ml, SISR "102 ng/ml, SRP "6 mg/l diagnose the development of atherosclerosis.