UA121709U - METHOD OF DIAGNOSTICS OF ATHEROSCLEROSIS DEVELOPMENT - Google Patents

Abstract

A method of diagnosing the development of atherosclerosis includes clinical examination, examination of low and high density lipoprotein cholesterol levels, arteriography. Additionally, serum polymorphism of the nitric oxide synthase gene (eNOS T786C), the content of thrombomodulin, folic acid, cobalamin, C-reactive protein (PSA) are determined. With homozygous carrier 786-SS, thrombomodulin levels> 5 ng / ml, folic acid <6 ng / ml, cobalamin <300 ng / ml, PSA> 6 mg / l diagnose the development of atherosclerosis.

Description

The proposed method of diagnosing the development of atherosclerosis belongs to medicine, in particular to therapy and rheumatology. It is prescribed and can be used in the treatment and examination of patients.

Ways of diagnosing the development of atherosclerosis are known. These include determination of low- and high-density lipoprotein cholesterol levels, arteriography (AN Okorokov.

Diagnosis of diseases of internal organs. - M.: Med. lit., 2003. - Vol. 6. - P. 75-85).

However, the known method is not effective enough and does not allow diagnosing the development of atherosclerosis even at the onset of the disease. Accordingly, there is no possibility to prevent atherosclerosis.

The basis of a useful model is the task of developing a method that would allow early diagnosis of atherosclerosis.

The task is solved by the fact that along with the study of low and high-density lipoprotein cholesterol levels, the polymorphism of the nitric oxide synthase gene (EMO5 17860), the content of thrombomodulin, folic acid, cobalamin, and C-reactive protein (CRP) is determined in the patient's blood serum by arteriography. With homozygous carrier 786-SS, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, cobalamin "300 ng/ml, SRP "6b mg/l, the development of atherosclerosis is diagnosed.

Application of the method. During hospitalization, the patient is examined, low- and high-density lipoprotein cholesterol levels are examined, and arteriography is performed. In the blood serum of the patient, the polymorphism of the eMO5 1786C gene is determined, the content of thrombomodulin, folic acid, cobalamin, PSA is determined by the immunoenzymatic method. With homozygous carrier 786-SS, levels of thrombomodulin "5 ng/ml, folic acid "b ng/ml, cobalamin "300 ng/ml, SRP "6b mg/l, the development of atherosclerosis is diagnosed.

A specific example of using the method.

Patient 0., 45 years old, was hospitalized with a diagnosis of rheumatoid arthritis. Inspected.

Low and high density lipoprotein cholesterol levels were studied. Arteriography was performed.

There are no signs of atherosclerosis. Polymorphism of the eMO5 T7860 gene was determined in blood serum.

The content of thrombomodulin, folic acid, cobalamin,

SRP Homozygous carrier 786-SS was established. Levels of thrombomodulin - 8.8 ng/ml, folic acid - 4.5 ng/ml, cobalamin - 220 ng/ml, SRP - 17 mg/l. The development of atherosclerosis was diagnosed. Arteriographic signs of the process were detected only after 14 months.

Thus, the proposed method of diagnosis allows establishing a diagnosis at the early stages of the development of the process.

Claims (1)

USEFUL MODEL FORMULA The method of diagnosing the development of atherosclerosis, which includes a clinical examination, the study of low and high-density lipoprotein cholesterol levels, arteriography, which is distinguished by the fact that the polymorphism of the nitric oxide synthase gene (EEEMO5) is additionally determined in the blood serum T786C), the content of thrombomodulin, folic acid, cobalamin, C-reactive protein (CRP), while homozygous carrier 786-СС, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, cobalamin "300 ng/ml , SRP »6 mg/l diagnose the development of atherosclerosis.