UA121635U - METHOD OF DIAGNOSTICS OF ATHEROSCLEROSIS DEVELOPMENT - Google Patents

Abstract

A method of diagnosing the development of atherosclerosis involves conducting a clinical examination, examination of low and high density lipoprotein cholesterol levels, arteriography, determination of the MTHFR C677T gene polymorphism in serum, thrombomodulin content, folic acid, osteocalcin, osteocalcin, and osteocalcin. With homozygous carrier 677-TT, thrombomodulin levels> 5 ng / ml, folic acid <6 ng / ml, osteocalcin <21 ng / ml, homocysteine> 20 μmol / l, PSA> 6 mg / l, IL-6> 10 ng / l diagnose the development of atherosclerosis.

Description

The proposed method of diagnosing the development of atherosclerosis belongs to medicine, in particular to therapy and rheumatology. It is prescribed and can be used in the treatment and examination of patients.

Ways of diagnosing the development of atherosclerosis are known. These include determination of low and high density lipoprotein cholesterol levels, arteriography. (A.N. Okorokov

Diagnosis of diseases of internal organs. - T. 6. - M.: Med. lit., 2003. - pp. 75-85).

However, the known method is not effective enough and does not allow diagnosing the development of atherosclerosis even at the onset of the disease. Accordingly, there is no possibility to prevent atherosclerosis.

The basis of a useful model is the task of developing a method that would allow diagnosing the onset of atherosclerosis at an early stage.

The task is solved by the fact that, along with the study of low and high-density lipoprotein cholesterol levels, the polymorphism of the methylenetetrahydrofolate reductase gene (MTNEV C677T), the content of thrombomodulin, folic acid, osteocalcin, homocysteine, C-reactive protein (CRP), interleukin is determined in the patient's blood serum by arteriography b (IL-6). With homozygous carrier 677-TT, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, osteocalcin "21 ng/ml, homocysteine 220 μmol/l, SRP 26 mg/l, IL-6 "10 ng/l diagnose the development of atherosclerosis.

Application of the method

During hospitalization, the patient is examined, low- and high-density lipoprotein cholesterol levels are examined, and arteriography is performed. In the blood serum of the patient, the MTNEV C677T gene polymorphism is determined. The content of thrombomodulin, folic acid, osteocalcin, homocysteine, SRP, IL-6 is determined by immunoenzymatic method.

With homozygous carrier 677-TT, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, osteocaludin "21 ng/ml, homocysteine "20 μmol/l, SRP "b mg/l, IL-6 "10 ng /l diagnose the development of atherosclerosis.

A specific example of using the method

Patient Ye., 47 years old, hospitalized in the clinic with a diagnosis of rheumatoid arthritis. Examined

Low and high density lipoprotein cholesterol levels were studied. Arteriography was performed

From vessels. There are no signs of atherosclerosis. The MTNEV gene polymorphism was determined in blood serum

Сб677Т. The content of thrombomodulin, folic acid, osteocalcin, homocysteine, SRP, IL-6 was determined by immunoenzymatic method. Homozygous carrier 677-Т1Т was established. Levels of thrombomodulin - 9 ng/ml, folic acid - 3.8 ng/ml, osteocalcin - 16 ng/ml, homocysteine - 28 μmol/l, PSA - 14 mg/l, IL-6-16 ng/l. The development of atherosclerosis was diagnosed. Arteriographic signs of atherosclerosis were established only after 12 months.

Thus, the proposed method allows diagnosing atherosclerosis in the early stages of the process.

Claims (1)

USEFUL MODEL FORMULA 40 The method of diagnosing the development of atherosclerosis, which includes conducting a clinical examination, researching low and high-density lipoprotein cholesterol levels, arteriography, which is distinguished by the fact that the MTNEV C677T gene polymorphism, the content of thrombomodulin, folic acid, osteocalcin, homocysteine, SRP, IL are determined in the blood serum -b, and when homozygous 45 carrier 677-TT, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, osteocalcin -21 ng/ml, homocysteine 220 μmol/l, SRP "b mg/l, IL-b6 "10 ng/l diagnose the development of atherosclerosis.