UA121099U - METHOD OF DIAGNOSTICS OF ATHEROSCLEROSIS DEVELOPMENT - Google Patents

Abstract

A method of diagnosing the development of atherosclerosis includes clinical examination, examination of low and high density lipoprotein cholesterol levels, arteriography. Additionally, serum polymorphism of nitric oxide synthase gene (eNOS T786C), glycosaminoglycans (GAG), interleukin 6 (IL-6), homocysteine content is determined. When homozygous carrier 786-SS, levels of GAG> 28 μmol / l, IL-6> 10 ng / l, homocysteine> 20 μmol / l diagnose the development of atherosclerosis.

Description

The proposed method of diagnosing the development of atherosclerosis belongs to medicine, in particular to therapy and rheumatology. It is prescribed and can be used in the treatment and examination of patients.

Ways of diagnosing the development of atherosclerosis are known. These include determination of cholesterol levels of low and high density lipoproteins, arteriography of Ts|A.N. Okorokov

Diagnosis of diseases of internal organs. - T. 6-S. 75-85).

However, the known method is not effective enough and does not allow diagnosing the development of atherosclerosis even at the onset of the disease. Accordingly, there is no possibility to prevent atherosclerosis.

The basis of a useful model is the task of developing a method that would allow diagnosing the onset of atherosclerosis at an early stage.

The task is solved by the fact that along with the study of low and high density lipoprotein cholesterol levels, the polymorphism of the nitric oxide synthase gene (emo T786C), the content of glycosaminoglycans (GAG), interleukin b (IL-b6), and homocysteine are determined in the patient's blood serum by arteriography. At a homozygous carrier of 786-SS, levels of GAG»28 μmol/l, IL-6210 ng/l, homocysteine 220 μmol/l, the development of atherosclerosis is diagnosed.

Application of the method. Upon admission, the patient is examined, low-density lipoprotein and high-density lipoprotein cholesterol levels are examined, and arteriography is performed. In the blood serum of the patient, the polymorphism of the eMmOo5 T786C gene is determined, and the content of GAG, IL-b, and homocysteine is determined by the immunoenzymatic method. At a homozygous carrier of 786-SS, levels of GAG»28 μmol/l, IL-6210 ng/l, homocysteine 220 μmol/l, the development of atherosclerosis is diagnosed.

A specific example of using the method.

Patient V., 48 years old, was hospitalized in the clinic with a diagnosis of rheumatoid arthritis.

Examined Low and high density lipoprotein cholesterol levels were studied. Arteriography was performed. There are no signs of atherosclerosis. The emo T786C gene polymorphism was determined in blood serum. The content of GAG, GL-6, and homocysteine was determined by the immunoenzymatic method.

Homozygous carrier 786-SS was established. GAG levels - 34 μmol/l, IL-6-20 ng/l, homocysteine - μmol/l. The development of atherosclerosis was diagnosed. Arteriographic signs of the process were revealed only after 12 months. 30 Thus, the proposed method of diagnosis allows establishing a diagnosis at the early stages of the development of the process.

Claims (1)

USEFUL MODEL FORMULA The method of diagnosing the development of atherosclerosis, which includes a clinical examination, a study of the levels of low and high-density lipoprotein cholesterol, arteriography, which is distinguished by the fact that the polymorphism of the nitric oxide synthase gene (EEEMO5 T786C), the content of glycosaminoglycans (GAG), interleukin 6 ( IL-6), homocysteine, while homozygous carrier 786-SS, HAG levels »28 μmol/l, IL-b6 »10 ng/l, homocysteine 220 μmol/l diagnose the development of atherosclerosis.