UA110193C2 - Cartridge, drug portion filler for solid drugs, and also usage of cartridge dispenser and drugs - Google Patents

Abstract

The group of inventions characterizes the cartridge and dispenser of medicines, as well as the use of the aforementioned elements. According to a first aspect of the invention, a cartridge (900) that is inserted into the dispenser (1) of medication for portions (T) of a solid drug and made with a receiver for accommodating portions (T) of the medicament, wherein the cartridge (900) has a coupling device (910) which is configured to dispense a given portion (T) of a medicament, and which comprises a moveable device (940) for separating a predetermined portion (T) of the drug from the receiver and for dispensing the drug dispenser (1) means, at this disconnecting point the device (910) is made for establishing a kinematic connection with the device (14, 220, 224, 226; 15, 210, 230) of the control device for the disconnect device (910) provided in the dispenser (1), and the portions thereof of the drug (T) when disconnected, as well as their dispensing or release from the dispenser, do not touch the dispenser or its parts. The second aspect of the invention also relates to the dispenser (1) of medication for portions (T) of a medicinal product made of solid substance, which is arranged to accommodate a replaceable cartridge (900), the cartridge (900) having a receiver for portions (T) of the drug, and a disconnecting device for dispensing specified portions (T) of a medicament, the dispenser (1) of the medicament having at least one device (14, 220, 224, 226; 15, 210, 230) for controlling the disconnecting device (910) , as well as a means for establishing kinematic coupling between at least one device control and configured to move the device (940) on the disconnect device (910) et seq.

Description

(T) medicinal product, while the dispenser (1) of medicinal products has at least one control device (14, 220, 224, 226; 15, 210, 230) for the disconnecting device (910), as well as means for establishing a kinematic connection connection between at least one control device and a movable device (940) on the disconnecting device (910) and serves to separate the given portion (T) of the medicinal product from the receiver and to dispense the medicinal products from the dispenser (1), and therefore, portions of the medicinal product (T) when unbundled, as well as when they are dispensed or released from the dispenser, do not touch the dispenser or its parts. In addition, the use of a cartridge (900) for storing portions (T) of medicinal products and the use of a dispenser (1) of medicinal products for storing and dispensing portions (T) of medicinal products are claimed, while the portions of the medicinal product are hormonal preparations. iya 13 j Eh 1 tsa And heaven! (c) (c , their d A

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FIGLA

The invention relates to a cartridge for a medicine dispenser, in which portions of a medicine made of a solid substance, for example tablets, are contained in a preferably columnar arrangement. In addition, the invention relates to a medicine dispenser, as well as a medicine dispenser with a replaceable cartridge contained in it. The invention also relates to the use of a cartridge and dispenser of medicinal products for storing or dispensing portions of medicinal products, primarily hormonal preparations.

It is known to provide the user with portions of medicines made of a solid substance, such as tablets, in various types of packaging. For example, such solid drugs are very often supplied in so-called blister packs (RTP: рыпп-Ийгоцо раскКк), sealed separately, in which they are generally packaged in sealed cells. For this, in most cases, a transparent synthetic film, which has receiving trays for portions, is brewed in aluminum foil, while separate cells are formed in which tablets are contained.

Before taking the tablets, they are extracted from individual cells by pressing them from the receiving tray through aluminum foil. This type of packaging is widely distributed because each individual tablet is thus securely stored and protected from external harmful influences. In another form of packaging, solid drugs are supplied in vials in which the individual tablets are respectively unwrapped. In this case, consumers must extract the pills separately by hand.

In yet another form of packaging, the tablets are, again accordingly unpackaged, in a columnar form of arrangement in a tube. And in this case, separate tablets are pulled out by hand. This is problematic in that there is a danger that individual tablets will fall out and become damaged or contaminated. In addition, the consumer has no control and overview over the number of pills already taken.

In order to ensure convenient dosing, reliable medical assistance and careful handling of portions of the medicinal product, it is advantageous if portions of the solid medicinal product packaged in this way are offered for consumption by the consumer in a dispenser of medicinal products. In this case, portions of the medicinal product are contained in the dispenser and can, if necessary, be dispensed from the dispenser. The advantage of such systems consists, firstly, in particular, in the fact that the portions of the medicinal product in the dispenser are protected from external influences, and that there is a possibility by suitable means to provide that the portions are issued in a pre-dosed amount.

For the use of medicines that are packed in blister plates, for example, in UMO 2005/028316

A2 describes a dispenser that has a slot at one end for receiving a blister plate. To dispense individual tablets, the blister plate is only partially withdrawn from the dispenser, so that only one individual tablet or only a certain small number of tablets is released. This is ensured by the fact that the blister has protrusions that are captured by the grips in order to set a certain feed when pulling the blister from the dispenser.

In иЙ5 3,591,043 A described container and dispenser having a deformed wall and an opening in the end side. When pressure is applied to the end side due to the deformation of the closing element, the lower closing element opens.

In 5 6,409,020 VI another dispenser containing a blister with circumferentially arranged blister cells is disclosed. Tablets in blister cells are, in principle, accessible through a window on the upper side of the dispenser, but only when the consumer presses at least one of the tabs located on the side of the dispenser, which in the rest position extends above the window, thereby closing the tablets and protecting them from unauthorized access. If the consumer presses the tab, the plate bends and releases the tablets.

A dispenser for breath fresheners and cough drops is disclosed in Mo. 5 patent 5,080,258.

The lozenges contained in this dispenser are stacked. Under the action of the spring force, the lozenges in the guide are forced upwards and thus fall into the ejecting head, which has an ejecting cam, by means of which the lozenges are individually dispensed on the side of the dispenser.

Also, patent O5 5,366,112 describes a dispenser for refreshing lozenges and cough lozenges, in which the lozenges are stacked. Under the action of the spring, also in this case, lozenges are pressed up and released by the ejecting head with the ejecting cam provided separately on the dispenser. Lozenges are in the store In this case, the lozenges are in the store, which can be provided with a simple protective film for transportation. Tablets, as stated in patent O5 5,080,258, are dispensed from a dispenser on the side.

EP 1 189 822 U1 discloses a tablet dispenser for medical needs. It contains a container made in the form of a tube, in which the tablets are contained in the form of a stack and are under the tension of a spring. Tablets are dispensed from the dispenser on the side by means of an ejector mechanism controlled from the dispenser head 60.

05 2003/0132239 Ai1 describes a magazine for placing stacked tablets, for example refreshing lozenges and cough lozenges, which is provided for use in a tablet dispenser. Tablets are in the store under spring tension and are issued from the dispenser on the dispenser head with the help of an ejector across the dispenser axis.

In addition, patent OB Mo 5,230,440 discloses a dispenser for pills such as contraceptives, flints for lighters or sweets such as candies. Tablets or the like are contained in a stack in a sleeve that can be inserted into the dispenser. Tablets or the like are dispensed from a dispenser on the side.

In patent OZ Mo 5,048,720, a dispenser for sweets or tablets is described, which has a case and a store fixed in it. Due to the store, two chambers were formed in the building. One of the chambers in the shop contains sweets or pills. Sweets or pills are dispensed from the side when serving the dispenser due to the fact that the thumb-operated slider on the magazine is actuated and, thereby, an ejector for side dispensing of an individual sweet or pill.

Next, in OE 42 30 452 A1, a container for storage and separate delivery of dragees placed in carriers is opened. To dispense the dragees, the container has a pushing pusher and a pushing tongue, in which at least the tip is elastic. Due to the actuation of the pressing pusher, the tip moves in the direction of pressure, and due to the shaping of the guide for the pushing tongue - directly through the hole in the carrier shell. The hole is located on the outer edge of the carrier, directly opposite the second hole, through which the dragee can be squeezed out by the tip of the ejecting tab pressed into the carrier.

From MO 2008/071233 A1, a pill dispenser is known, which has an insertable storage device.

The dispenser has a pill dispensing device, which includes a trigger button, a pill dispensing slider, and a button on the dispensing slider.

In RE 88 07 774 Sh1, a tablet dispenser is disclosed, which has a handle that is connected to the tablet dispenser, a pusher and a cover that is provided with an opening through which a tablet to be extracted falls out.

From ME 31 43 953 AT is known a dispenser for products that have the form of a pill, containing a main element with a movably installed dosing pusher in it. A cartridge for tablets or a receiver for tablets can be inserted into the dispenser. When the dosing device is activated

Products fall out of the dispenser separately from the pusher.

B 5 3,270,915 A describes a dispenser for pharmaceutical tablets having an outer container, a cylindrical magazine that can be inserted into the dispenser, a bottom plug, and a pusher rotating in the plug. The rotating pusher contains an opening through which the tablets fall out.

Regarding most of the known above-mentioned drug dispensers, it is not specified how tablets, lozenges, candies or the like are introduced into the dispenser. Although patent OB Mo 5,230,440 states that the sleeve, which contains tablets or the like, is interchangeable and is inserted into a cavity in the dispenser. Also, in patent О5 Mo 5,048,720 it is stated that the magazine, which contains sweets or pills, is inserted into the body. However, it has been found that the use of such dispensers, especially when used by persons with poor vision or in low light conditions, is problematic because the dispensed tablets or the like cannot in all cases be captured by the consumers and the tablets or the like fall. and at the same time get lost. First of all, if the dispenser dispenses small pills, the person using it may not be sure if they have received a pill or not.

Also, in known devices, it is not ensured that the tablets will not be damaged in any phase of use, for example also when they are placed in a dispenser.

Therefore, the basis of this invention lies in the problem that the known dispensers of medicinal products do not provide sufficiently simple and reliable handling during application, as well as when dispensing portions of the medicinal product from a solid substance, so the task is to develop a means for storing and dispensing portions of a solid drug, primarily a cartridge for a drug dispenser, a drug dispenser, as well as a drug dispenser in which there is a similar cartridge for portions of the drug, with the help of which the mentioned problems in the application and dispensing of portions are absent.

First of all, the medicine dispenser and the cartridge must be simple and reliable with respect to their manipulation and, above all, ensure that the person using them can be guaranteed to get each individual portion of medicine from the dispenser without that portion being lost, and a person, in the worst case, would not notice it. In addition, portions of the drug from a solid substance should not be damaged during transportation and storage, as well as when used in a dispenser.

This problem or task is solved by a replaceable cartridge according to item 1, a drug dispenser according to item 10, a drug dispenser for portions of a solid drug containing such a replaceable cartridge according to item 11, a cartridge application according to item 8, as well as the use of a medicine dispenser in accordance with clause 20 of the claims. The best variants of the invention are indicated in the dependent clauses.

Since in the description of the invention and in the formula of the invention, the terms "portions of a medicinal product from a solid substance" and "portion of a medicinal product" are used later, they mean pills, dragees, capsules, tablets and other solid forms of application. To simplify the description of the invention in the future, instead of other portions of medicines (from a solid substance), the term "tablets" is used. Therefore, when using this concept, you should keep in mind any kind of portions of medicinal products (from a solid substance).

Since further in the description of the invention and the claims of the invention, concepts are used that mean, first of all, constructive elements of the subject of the invention, such as "means of placement", etc., these concepts, regardless of whether they are used in the singular or plural, should be understood as in the singular , as well as in the plural.

A cartridge according to the invention and a solid drug dispenser are used to dispense tablets together, with a cartridge having a tablet receiver inserted into the dispenser for use. Preferably, the cartridge and the dispenser serve for the use of drugs, and especially preferably for the use of hormonal drugs, and most preferably contraceptives or drugs for hormonal therapy in the form of tablets.

If the drug contained in the cartridge is, for example, a hormonal drug, for example, for contraception, it can be taken in the usual way, for example in an approximately 24-hour rhythm according to a biphasic continuous regimen. Then follows a period without taking the drug (break period). For example, the period without taking can be 7 days or 4 days or another fixed number of days. Instead of the above-mentioned constant periods, for example, 21 days of intake and 7 days of break, or 24 days of intake and 4 days of break, or instead of another fixed regimen of intake, individual medicinal products, for example, for contraception, can also be taken for

With a flexible intake schedule, with an intake phase lasting, for example, a minimum of 24 days and a maximum of 120 days, and a break phase of, for example, 4 days.

The cartridge according to the invention is inserted into the medicine dispenser and is replaceable.

It is replaced when it is empty. An empty cartridge is replaced by a refilled cartridge. The refilled cartridge is used to fill the dispenser with tablets. For safe storage and transportation of the cartridge, it can be placed in a preferably sealed container, for example, in a hermetic bag or blister, for example, made of aluminum foil, in which a receiving tray for the cartridge is made by cold forming, until the cartridge needs to be inserted into the dispenser. . However, in principle, the cartridge can be connected to the dispenser and inseparable, so that when the cartridge is emptied, the dispenser is thrown away.

Preferably, the cartridge is made with a receiver for placing tablets in a columnar arrangement. Therefore, the cartridge is preferably cylindrical and preferably has a cylindrical receiver.

In order to achieve the changeability of the proposed pill cartridge in the drug dispenser, the dispenser has means for accommodating the cartridge, such as a receiving shaft extending axially therein, into which the cartridge can be inserted. To use the medication dispenser, the cartridge is inserted, for example slid, into the placement means, for example into the receiving shaft. Thus, the cartridge and the dispenser can be in a spatial-object relation to each other and together form the proposed combination of the dispenser of medicines and the cartridge, which are mounted in a single node.

According to the invention, the cartridge has a disconnecting device for given portions of the drug, namely, preferably at one end. This disconnecting device contains a movable device for separating a given portion of the drug from the receiver and for dispensing from the drug dispenser. The disconnecting device is designed to establish a kinematic connection with the control device for the disconnecting device provided in the medicine dispenser. Preferably, this disconnecting device is designed in such a way that the tablets are dispensed separately or in another specific quantity, for example, two tablets at the same time. For this, the disconnecting device is designed so that it can be actuated by means of a kinematic connection between the disconnecting device and the control device or several control devices that are provided on the medicine dispenser. The control devices may include both manual controls provided on the medication dispenser to dispense a single pill (or several tablets at the same time), and devices in the dispenser to transmit the manually actuated movement controls from the controls to the disconnecting device. Because the disconnecting device for tablets in this embodiment of the invention is provided on the cartridge, such a device on the medicine dispenser is not provided. In contrast, the control device or control devices for the decoupling device in this embodiment are located on the medication dispenser. These control devices are mainly in a mechanical kinematic connection with the disconnecting device. An electromechanical or purely electronic kinematic connection is also possible. To implement a mechanical kinematic connection, for example, a pin can be provided on the disconnecting device on the cartridge, which can also be called a leash. In this case, by actuating the controls on the dispenser, the movement is transmitted, for example, to a cam adapted to this leash equipped with a recess in the medication dispenser, and from this cam to the leash and, thereby, to the disconnecting device. The movement made by manual actuation of the control means on the dispenser is transmitted to the cam, mainly through other intermediate mechanical elements, such as transport levers, which are devices for transferring movement from the control means to the disconnecting device.

The implementation of the disconnecting device on the cartridge has several beneficial functions.

The uncoupling device serves to dispense to the consumer the tablets contained in the cartridge, individually or in a certain amount. Thus, the consumer is able to extract pills from the cartridge confidently, without more than one pill being mistakenly dispensed at a time.

In addition, the disconnecting device in every way closes the receiver and, thereby, the tablets contained in the receiver from external influences, so that the tablets contained in it cannot be damaged or spoiled in any other way. First of all, the separating device serves, for example, during transportation and during storage, as well as during service by the consumer as a closing element, so that the tablets are protected from external influences.

By implementing a release device on the cartridge, it is also ensured that the tablets cannot accidentally fall out, because the locking element cannot be removed by mistake. The fact is that the decoupling device can preferably be activated only when, and thus, the tablets can be dispensed individually (or in a certain amount) only when the cartridge is inserted into the medicine dispenser. Controls are provided to actuate the release device on the cartridge on the drug dispenser, as simple handling requires actuating the manual controls on the dispenser to dispense an individual pill (or number of pills). In any event, it is impossible for the disconnector to dispense more than one pill (or more than a certain number of pills) from the cartridge, and it is also extremely unlikely that the cartridge lock on the disconnector will be manually activated once the cartridge is not in the dispenser.

In addition, the complexity of installation when inserting the cartridge into the dispenser is minimal.

For example, it may be sufficient that the cartridge is inserted axially into the means for placing the cartridge in the dispenser, without the need to remove the cover and without the need to take other mounting measures. Thus, it is not necessary, for example, to remove the cover, as in the case of the dispenser of patent 5 Mo 5,230,440, in order to insert the cartridge into the receiving shaft in the dispenser. This facilitates the use of the cartridge dispenser to a great extent. This advantage is achieved, first of all, due to the fact that the disconnecting device is simultaneously a locking element and is provided on the cartridge, and not on the dispenser.

In addition, the disconnecting device when manipulating the dispenser is repeatedly and frequently activated to extract the tablets. Because the disconnecting device is provided on the cartridge and not on the medication dispenser, the resulting wear on the disconnecting device is not as detrimental to the consumer as if the disconnecting device were provided on the medication dispenser , because the release device is replaced with the cartridge when it no longer contains tablets. If the disconnecting device was provided on the dispenser, and not on the cartridge, through the appropriate selection of materials and due to a suitable design, it should be designed for a much longer service life. In addition, dust from tablets, which can accumulate, primarily in the disconnecting device, is removed together with the bo cartridge and does not accumulate during the entire service life of the dispenser in it. All the same, this dust in combination with moisture (air) is a good nutrient ground for the nucleation of microorganisms.

In another preferred embodiment of the invention, the decoupling device has a pusher designed to move essentially vertically along the axis of the cartridge. The pusher serves as a structural element, with the help of which the tablets are separated. A pusher can take one pill at a time and move it individually in a pushing motion relative to the stack. Preferably, the tablets in the cartridge are stacked one on top of the other in a columnar stack located in the receiver in the cartridge. A pusher can then be positioned at one end of this stack and separate the tablets one by one from the stack.

For this purpose, the pusher can preferably have, in the axial direction, a reception section open on both sides for a certain portion of the medicine, for example, for a single tablet or for two tablets at the same time or for several, i.e. more than two, tablets at the same time.

When taking a pill from a stack, this receiving section is closed on the side that is on the opposite side of the stack. The receiving section is preferably sized to accommodate (only) one individual tablet (or a certain number of tablets). In order to ensure efficient and reproducible separation, the height of this section can be exactly the same as, or slightly greater than, the height of an individual tablet (or the height of a stack of a certain number of tablets). Therefore, in this case, only one single tablet (or a certain number of tablets) is placed in the receiving section and separated from the stack of tablets with a pushing movement.

In addition, the decoupling device may include a lower bowl. In addition, the pusher is made with the possibility of movement relative to the receiver in the cartridge between two displacement positions vertically or essentially vertically of the axis of the cartridge. The lower bowl can, in particular, serve to close the receiving section on the side opposite the receiver in the cartridge, when the receiving section in one of the shift positions (the second shift position) is coaxial with the receiver. In this case, the tablet falls into the receiving section and is held there by the lower cup. The pusher then moves to the other of the two shift positions (the first shift position) in which the tablet can be withdrawn.

In one preferred embodiment, the lower bowl in this case may have an outlet offset to the axis of the cartridge and coaxial with the (open) receiving section, if the pusher

Zo is in one of two shift positions, preferably in the first shift position. Then the tablet falls out through the exit hole and can be withdrawn in this way. At the same time, the tablet is pulled out on the side of the disconnecting device, which is opposite to the receiver. Alternatively, for dispensing the tablet, the first shift position may also be selected such that the tablet is dispensed on the same side of the disconnector as the receiver. For this, the pusher would have to extend from the dispenser laterally, and the first shift position of the receiving section would have to be in the prominent side part of the pusher. In addition, tablets can be dispensed from the side, that is, in the plane in which the tablets are moved by the pusher in the process of shearing. In all these cases, the tablets can be respectively in the same position and separate, in which they are located with their main surfaces on top of each other, or in a position in which they are located standing, that is, with their side surfaces on top of each other.

Preferably, the decoupling device switches between two offset positions. One of the two offset positions may be the rest position, and the other offset position may be a second position from which the disconnecting device is precisely returned to the rest position, for example, while in this second position it is under the tension of a spring that returns it in a resting position. It is possible that the second shift position, in which the receiving section in the pusher is coaxial with the cartridge receiver, is the rest position, or that the first shift position, in which the receiving section in the pusher is coaxial with the exit hole in the lower cup, is the rest position.

The lower bowl of the cartridge can be inserted, first of all, flush with the outer casing of the dispenser. This prevents the user from tampering with the cartridge from the dispenser, for example, before the cartridge is completely empty. In addition, the cartridge is inserted in the dispenser so that the tablets and, thereby, the medically active substances in the tablets do not touch the dispenser or its parts when they are separated, as well as when they are dispensed or released from the dispenser. This variant of implementation is particularly favorable from the point of view of legal norms regulating the manufacture and use of medicines.

In one preferred embodiment of the invention, the cartridge and the medication dispenser are designed in such a way that the cartridge can be inserted into the dispenser in only one (axial) rotational orientation, such that one of the two halves of the cartridge, which bound the pill-containing receiver 60, is directed towards front side, and the other to the back side of the dispenser. This allows you to use both halves of the cartridge differently. For example, one half may have inscriptions, such as information about the pills contained in the cartridge, and the other may be transparent to make the pills visible from the outside.

According to one embodiment, the cartridge is designed so that tablets can be dispensed in an axial direction. By this it should be understood that the tablets are dispensed from the dispenser not from the side, but from the end of the dispenser, namely, in the direction passing in the axial direction, that is, along the axis of the dispenser or parallel to this axis or along the axis of the cartridge or parallel to this axis. In addition, it is advantageous for this if the medicine dispenser is designed so that tablets are dispensed in an axial direction.

Thus, a person using the dispenser can extract pills to be dispensed simply by holding the dispenser in one hand, while the person can actuate the controls provided on the dispenser to dispense the pill with the same hand, so that the pill falls on the other hand. To do this, it is enough if the user holds the dispenser with the side from which the cartridge is inserted into the dispenser, above the other hand, and then activates the dispenser to dispense the pill. At the same time, the orientation of the dispenser, which goes further, in relation to the hand that does not hold the dispenser, is not required, so that the tablet reliably falls into the consumer's hand, and thus he can confidently grab the tablet. Therefore, unsuccessful service, in which the tablet mistakenly falls to the bottom and does not fall into the consumer's hand, is practically excluded. Thus, handling the dispenser is safer and more reliable than with known dispensers.

In another preferred embodiment of the invention, the cartridge contains a transport fuse seated in the cartridge body, preferably with a friction lock, to prevent movement of the tablets during storage and transportation of the cartridge. First of all, this transport fuse can be seated in the receiver, preferably with a friction lock and made with the possibility of movement in the axial direction with a tolerance compensation plug. This tolerance compensation plug is inserted into the receiver before filling the cartridge with pills and after filling the cartridge with pills it is pressed tightly against the stack of pills.

Because the tolerance compensation plug sits in the receiver with a friction lock, it can keep the pill stack tightly packed even when the cartridge is not in the dispenser, such as when the cartridge is handled separately, such as during storage or transportation. Tightly holding the stack of tablets together is necessary to prevent the tablets from moving freely in the receiver so that they cannot tip over and thereby skew and make dispensing tablets difficult. In addition, tablets with constant movement relative to each other could be subject to unwanted abrasion. At the same time, it is also necessary to take into account that the tablets have a thickness tolerance, which leads to a change in the height of the stack of tablets. If the thickness tolerance of a tablet with a thickness of 3 mm is, for example, 150 microns, the change in the height of a stack of 30 tablets is about 5 4.5 mm. Thanks to the tolerance compensation plug, the stack, regardless of its actual height, is always firmly held in the receiver, that is, even when the cartridge is not yet inserted into the dispenser. A tolerance compensation plug has, for example, compared to a pressure spring, such as the resilient means of patent 05 5,230,400, which would press one against the other and thereby fix the tablets in the receiver, the advantage that the tablets during transport and storage are packed, lying on top of each other without effort, and are not, as in the case of a pressure spring, under variable spring tension depending on the height of the stacked tablets. Thus, much more economical storage of tablets is achieved than in the case of well-known stores.

In order to provide frictional closure of the tolerance compensation plug in the cartridge receiver, the plug has at least one locking means for locking with a profile extending in the axial direction on the inner wall of the cartridge receiver. This profile can be formed, for example, by a transverse grooved profile consisting of transverse grooves running parallel to each other. For example, the transverse grooved profile may form at least one cracking band that extends axially on the inner wall of the cartridge or be provided along the entire inner perimeter of the inner wall of the cartridge. Due to the performance of the profile in the form of a cracking profile, a geometric closure is achieved in one direction (toward the outlet hole), and in the other direction, a frictional closure of the plug.

The at least one locking means on the tolerance compensation plug can be formed, first of all, by at least one outwardly acting and spring-loaded element locking with the profile, with locking lugs. For example, two spring elements with locking protrusions on opposite sides of the base part of the plug can be provided, while the spring elements are preferably approximately axially spaced and outwardly elastic because spring levers having inputs into the profile, for example, in two confronting each other snap strips that fix protrusions. The tolerance compensation plug can be first inserted into the cartridge receiver by means of spring elements, so that at least one locking means is directed upwards and thus prevents slippage.

In another preferred embodiment of the invention, the cartridge contains a tablet feeder made axially movable in the receiver and passing through at least one axial slot in the cartridge, which serves to capture the delivery means located in the medicine dispenser, for example, the delivery bottle, which also made with the possibility of movement mainly in the axial direction, as well as for the transmission of a mainly acting externally, preferably axially directed elastic force on the tablets, which are contained in the cartridge in a mainly columnar arrangement and, thereby, for pressing the mainly columnar structure of tablets through the feeding means.

Through the feed means, for example the feed barrel, a force is produced on the stack of pills in the receiver, which occurs, for example, from springs acting on the feed means, for example constant force springs, so that the stack of pills is constantly under the influence of a force in the axial direction if the cartridge is in medicine dispensers. Due to this, it is achieved that the tablets in the receiver cannot move freely. By this force, the stack of tablets is pressed against the receiving section in the disconnecting device, so that always one tablet enters the receiving section when the pusher is in the first displacement position.

In order to accomplish this, a feed means that slides externally along the cartridge, such as a feed bugel, can be in contact with the tablet reiter in a geometrical lock. For this purpose, the axially freely movable tablet rater in the cartridge receiver can pass through at least one axial slot on the cartridge, for example, with one lever or two levers (in this case, respectively through one axial slot), so that the feeding means through this lever or another projection can to exert effort on the rater of pills and, thus, on the stack of pills. Thus, when the cartridge is in the medicine dispenser, an axial force acting in the direction of the disconnecting device is applied to the stack of tablets. Due to this, the stack is constantly pressed down, so that when the receiving section in the decoupling device is coaxial with the receiver, one tablet can fall into the receiving section.

З Instead of the tablet rater, which has a lever passing through a slot in the cartridge housing, or several levers that pass through several slots, while external force through the pill rater on the stack of tablets is detected, another design option can also be chosen, in which the cartridge housing slot is not provided. In the latter case, the force on the stack of pills must be done in another way, for example through an axial transmission means, to which an external force is applied only at one end of the cartridge body or at both ends of the cartridge body, which then leads to the axial application of force to the stack of pills. Such a design option can be implemented, for example, due to the fact that, preferably, at the lower end of the cartridge case, a tape is introduced into it and passed through a stack of tablets. Then, when this tape is pulled on a stack of tablets, an axial force acting downwards is revealed. For example, the tape covering the stack of pills can be removed from the cartridge body laterally at the base of the stack of pills on both sides. Or the tape is output only on one side, and on the other side it is fixed to the base of the cartridge case. As an alternative, an axially movable rod sitting on the stack of tablets and exerting an axial force on the stack may also be used.

In general, when a filled cartridge is inserted into the dispenser in the direction of introduction, the feeding means, for example, the feeding bugle, can be captured, for example, so that the feeding means with the help of the tablet rater is captured upwards. At the same time, this feeder, in addition, can block the cartridge in the dispenser with the help of at least one suitable fixing means, for example, due to the fact that the captured feeder runs into the landing surface of the locking lever located in the upper region of the dispenser to lock the cartridge in the dispenser. Then, with the gradual discharge of the cartridge, this means of supply can gradually move downwards, so that its position in the dispenser encodes the filling level of the cartridge. If this feeder finally reaches the (lower) end position that is set by the empty cartridge, the cartridge lock can thereby be released so that the cartridge can be withdrawn from the dispenser. This can happen, for example, due to the fact that the supply means in the lowest position brings the locking levers to the unlocked position and, if necessary, additionally unlocks the corresponding ejection means for the cartridge.

In order for the cartridge to remain fixed after insertion into the receiving shaft or, in general, after inserting the cartridge into the means of placement in the dispenser, at least one fixing means is provided for fixing/blocking the cartridge in the medicine dispenser. This fixing/blocking by means of fixing means is preferably done in such a way that the cartridge is blocked after being inserted into the dispenser, that is, without removing the block, it cannot be pulled out while there are still pills in the cartridge. Only when the cartridge is empty can the locks in this case be released again so that the cartridge can be removed from the dispenser so that a new pill-filled cartridge can be inserted.

For fixing, such fixing means can be formed, for example, by one or more fixing protrusions on the cartridge and one or more fixing profiles, for example lugs, on the dispenser, which are fixed with the fixing protrusions, or vice versa, by one or more fixing protrusions on the dispenser and one or several fixing profiles, for example, lugs, on the cartridge. Of course, in principle, other fixing means of the type of fixing protrusions, which capture the protrusions, or two entering into each other fixing profiles or the like, are possible. For example, at least one locking means is rotatable. Preferably, it can be formed by rotary locking levers, which can be primarily double-armed and can be equipped with locking protrusions. Locking lugs can be provided, first of all, respectively on the lower part of the locking lever. Blocking agents are in the dispenser. Each locking protrusion is locked in a locking manner preferably on locking levers with a locking eye provided on the cartridge or the like. Instead of a locking lug, for example, a protrusion that catches the locking lug, or a recess into which the locking lug is inserted, can also be provided. In order to make the locking more secure, in addition, a pressure point may be provided on the locking levers at a place other than where the locking lug or lug is provided, which, when locked, is locked by the corresponding locking lug or lug, for example in the housing dispenser

In one particularly advantageous embodiment, the locking levers with locking protrusions can engage in the area adjacent to the area in which the cartridge is inserted into the dispenser, approximately in the end area of the dispenser adjacent to the means for placing the cartridge in the dispenser, for example, the receiving shaft. Then, on the cartridge in the bordering area, receiving ears must be provided, which include locking protrusions

From the locking levers. This bordering area can be, for example, on the lower bowl of the cartridge.

Additionally, an ejection lock may also be provided, which may include, for example, a free shift lever. The eject lock blocks the external, manually actuated means of ejecting the cartridge, such as the eject button, so that the cartridge can only be ejected when the cartridge no longer contains pills. This interlock blocks the actuation of these external ejectors and only unlocks them again when the cartridge is empty. This block can be removed, primarily by means of removing the block. For this purpose, an ejecting pusher may be provided, which is actuated by the ejection means, while the cartridge still contains at least one portion of the medicinal product.

If the above-mentioned at least one locking means leads to the blocking of the cartridge in the dispenser, i.e. that at least one locking means can no longer be unblocked without separately removing this blocking, apparently, in addition, at least one means for removing the blocking is provided. Preferably, this means for removing the blockage is made in such a way that the blockage is removed only when there is no longer a single portion of the drug in the cartridge. Without locking, the lock could be released simply by manually overcoming the locking force of at least one locking device. This would be possible if at least one fixing means is made with the help of a suitable execution of the parts forming the fixing connection in such a way that when applying the releasing force the fixing means slide one along the other, so that the fixing is removed.

However, if the blocking occurs when at least one locking means is pinched, for example because the locking lugs and locking profiles are designed so that the locking cannot be removed without destroying at least one locking means, unless the locking is simultaneously removed, at least one means for removing the locking must be released manually or preferably by means of a mechanism present in the dispenser, or a combination of these means. For this, the dispenser can be provided with at least one unlocking device, which, depending on the level of filling of the cartridge with tablets, releases the locking protrusions of the locking levers, namely, preferably only when the cartridge is empty. In this case, at least one locked locking means is released by at least one 60 unlocking means, while at least one locking means is switched from the locked position to the unlocked position without external manual actuation. This unlocking means can be, first of all, the feed means described above, which leads to the blocking of the cartridge when inserted into the locked position, and after emptying the cartridge into the unlocked position. To lock, the locking means are locked, while the feed means presses on one or more upper parts of the locking lever. In addition, the delivery means can also act to block the ejection and release it when, preferably, there are no more tablets in the cartridge. For this purpose, the ejector release locking actuator may actuate the release lever so that the ejector pusher and thereby the ejector are unlocked. Preferably, the ejector pusher, by means of the actuator of the ejector, presses on one or more lower parts of the locking means, preferably the locking lever, and thereby unlocks the cartridge locked by the locking means.

Unlocking can be done, for example, by suitable means in the medicine dispenser, the position of which depends on the filling level of the cartridge. For example, for this, an axially movably installed on the cartridge feeding bugle or other movable feeding means can be provided, which, for example, is respectively at the level of the tablet, which is in the cartridge in the uppermost position. As soon as there is no pill in the cartridge, the feed barrel or other feed means is also in the lower pole position and in this case releases the lock.

In order to be able to unblock the external, manual means for ejecting the cartridge, i.e. remove the ejection block, the same means for removing the block can be provided again, for example, the above-mentioned feeding bugle or other feeding means, the position of which depends on the level of filling of the cartridge.

In another embodiment of the invention, at least one elastic means is provided, which, when the cartridge is inserted into the medicine dispenser, exerts an elastic force on the cartridge in the axial direction against the direction in which the cartridge is inserted into the medicine dispenser (injection direction). Due to this, it is achieved that the cartridge in the dispenser is under tension, preferably spring tension. The force of the spring acting on the cartridge causes the pills in the cartridge to press against each other, so that when the dispenser moves in the cartridge receiver, they do not fall in one direction or the other. Despite the fact that the tablets are always under spring tension, the once established order in the stack of tablets is not disturbed.

The spring force affects, mainly, with the help of elastic means made in the form of a spring of constant force, first of all, two springs of constant force. Due to this, the stack of pills in the cartridge receiver, regardless of the actual height, i.e. the level of filling of the cartridge, can always be loaded with the same force, so that the handling of pills is gentle, without having to give up the advantage of applying tension to the stack of pills if it is only very small, for example, it contains two or three pills. At least one elastic means can be formed, for example, by a strip of spring steel.

The above-mentioned feeding means, for example the above-mentioned feeding bugel, which is preferably movable along the receiving shaft, can serve, first of all, also to transmit the elastic force to the tablets contained in the cartridge in a columnar arrangement. This means of delivery can, firstly, have the function of transferring an externally acting elastic force to a stack of tablets. This happens, for example, by attaching a spring or two springs to the delivery device, as well as to the counterpoise in the medicine dispenser. Preferably, two springs of constant force are provided, one of which is fixed at one end of the feed means, for example at one end of the feed bugle, and the other is fixed at the other end of the feed means, for example at the other end of the feed bugle, so that a symmetrical force is transmitted to the feed means. Alternatively, only one spring acting on the feed means can also be provided. In this case, the asymmetric forces created by it must be equalized. As already explained above, the feeding means may, among other things, also serve to remove the blocking for the ejection of the cartridge, ie the feeding means may be at least part of the blocking means.

The dispenser of medicinal products according to the invention, which, under certain circumstances, initially does not have a cartridge and which is made to accommodate portions of the medicinal product, having a receiver, as well as a disconnecting device for issuing given portions of the medicinal product, a replaceable cartridge, contains at least one a control device for a decoupling device, as well as means for establishing a kinematic connection between at least one control device and serves to separate a given portion of the medicinal product from the receiver and to dispense from the dispenser of medicinal products, made with the possibility of moving the device on the decoupling device devices

In another preferred embodiment of the invention, at least one narrow side of the medicine dispenser is provided with control means for dispensing portions of the medicine. In addition, another control means can be provided on another narrow side of the medicine dispenser, preferably on the second narrow side located opposite the first narrow side. These controls are used to manually dispense one tablet at a time from the cartridge. For this, the control means can be in mechanical, electromechanical or electronic kinematic communication with the disconnecting device by means of suitable transmission means to release one tablet at a time from the cartridge. Since the controls are provided on the narrow sides of the medication dispenser, they can be easily actuated even if the user uses the dispenser with one hand, for example, by holding the dispenser in one hand and applying pressure to the narrow sides of the dispenser and this activates the controls. Instead of locating the controls on one or both of the narrow sides of the dispenser, the controls may also be located elsewhere on the dispenser, such as on the front or back of the dispenser or on one or both ends.

In one preferred embodiment of the invention, the transmission means, by means of which the control means are in mechanical kinematic connection with the disconnecting device, are formed by devices for transmitting the movement produced by actuating the control means to the disconnecting device provided on the cartridge. For this, transport levers are applicable, for example, which, if necessary, are synchronized, for example, with the help of one toothed rack and a gear meshing with it, respectively. Transport levers can, for example, be in direct mechanical kinematic connection with the decoupling device, for example, in a connection with a geometrical lock, for example, due to the fact that the decoupling device is provided with a leash and a notch located with by a leash in a kinematic connection, at least on one of the transport levers or vice versa.

In addition, in one preferred embodiment of the invention, a window may be provided on the outside of the medicine dispenser housing, so that the tablets contained in the cartridge are visible from the outside. In this way, visual control of the filling level is possible

From the cartridge. In addition, the rater of tablets can be colored in contrast to the tablets, as well as, for example, to the background of the cartridge and/or other parts of the dispenser visible through the window.

This makes it easier to visually check the cartridge filling level through the window. For this purpose, the cartridge can preferably consist at least partially of a transparent material. In principle, it can also at least partially consist of translucent material.

First of all, the part of the cartridge that is visible through the window in the dispenser body can be made of a transparent or translucent material, so that the tablets contained in the cartridge are visible.

Additionally, the medicine dispenser may have an electronic display to display the number of tablets taken and/or to be taken and/or the number of tablets still in the cartridge. Each of these pieces of information can be displayed alternatively, for example by manual selection. The electronic display can additionally be made so that alarm signals are displayed on it, for example, exceeding or underestimating the period of time in which the pill should be taken, as well as the charge level of the battery used in the dispenser. In addition, with the help of the display, the status of the various phases of reception can be visualized, for example, an indication that the consumer is in the first, second, third or eighth phase, while the first phase can cover, for example, a continuous 24 days, the second phase, for example, flexible from 0 to 96 days, and the third phase is again permanently 4 days.

In order for the specified data to be shown on an electronic display, an electronic circuit is provided, preferably in the form of a board with an integrated semiconductor circuit placed on it. In addition, switches, preferably electrical control keys, can be mounted and connected on the board so that necessary data can be entered, for example, to select the display mode (number of pills taken, number of pills still in the cartridge). In addition, the dispenser may be provided with electrical switches to automatically detect certain operating states of the dispenser with the cartridge, such as first putting the dispenser into operation with the first insert, or first inserting the cartridge into the dispenser, resulting in, for example, activation of the batteries , which serve to power the electrical circuit and the electronic display, i.e. connect to the circuit and the display, in addition to dispensing the pill, ejecting the cartridge and/or detecting a certain small amount of pills remaining in the cartridge so that it can be correctly displayed how many tablets are still in the cartridge. Although, for the mentioned last function, it is usually sufficient, based on the number of tablets in a fully filled cartridge, to accordingly calculate how many tablets are still in it, if accordingly it is detected when one tablet is dispensed. True, this indication in the event that the number of tablets due to the inevitable tolerance in the thickness of the tablets in a fully filled cartridge fluctuates, may be erroneous. By detecting that there are, for example, four more pills in the cartridge, this error can be eliminated.

Next, the invention is explained in more detail using examples of its implementation, which are schematically depicted in the figures. However, the invention is not limited to the examples, but indicates only the best implementation options. Other forms of implementation with variants of individual features of the invention are also possible and are included in the scope of protection of the invention. At the same time, the same reference designations on individual figures mean the same or functionally identical or functionally corresponding elements. In particular, it is shown on:

Fig. 1A: a perspective view of a dispenser according to the invention with an inserted cartridge in a front view,

Fig. 1B: as fig. 1A in the rear view,

Fig. 2: a perspective view of the interior of the dispenser with the cartridge inserted, with the dispenser shown from the back side,

Fig. 3: a perspective cut of the lower part of the inner frame of the housing with the parts of the disconnecting device necessary for dispensing tablets, while the inner frame of the housing is shown from the front side of the dispenser,

Fig. 4: sectional view of a pill-filled cartridge with a disconnection device when viewed from the front side,

Fig. 4A: sectional view of the cartridge head when viewed from the front side,

Fig. 5: a perspective view of the dispenser without the outer casing with the inserted cartridge filled with pills (open) when viewed from the back side,

Fig. 5A: as in FIG. 1, cutout of the pressure point on the left locking lever,

Fig. 6: a perspective view of the internal frame of the dispenser body with the feeding tube and springs of constant force when viewed from the back side of the dispenser,

Fig. 7: a detailed view of the dispenser without the outer casing when viewed from the rear side with

With locks for the cartridge,

Fig. 7A: view as in fig. 7, a detailed perspective view of the left part of the dispenser with a blocked cartridge,

Fig. 7B: as fig. 7A with an unlocked cartridge,

Fig. 8A: a partial perspective view of the lower part of the dispenser without the side part of the housing with the eject button and the free switch button with a full cartridge when viewed from the right side,

Fig. 8B: as in fig. And, with an empty cartridge,

Fig. 8B is a perspective view of a free-shift key with a twisted bending spring and ejector pusher, viewed from the rear side,

Fig. 8G: as fig. 88, when the cartridge is ejected,

Fig. 8D: a section through the dispenser without the front and rear parts of the case when viewed from the back side,

Fig. 9: detailed view of the dispenser when viewed from the rear side.

Shown in fig. TA, 1B dispenser 1 is used to dispense T tablets, which are taken, for example, for contraception. First of all, the dispenser is suitable for dispensing contraceptives that are taken every day in the so-called flexible mode, that is, in the first phase of reception, which lasts 24 days, then in the second phase of reception, which lasts 0-96 days, so that the first and second phase reception can last up to 120 days. In this case, the person applying decides after the end of the first phase of reception when the reception should be interrupted and the phase without reception should begin. During the 4-day non-admission phase following the second intake phase, the first intake phase again follows.

It goes without saying that the dispenser can also be used to dispense other T pills, such as hormone therapy medications, diuretics, or antihypertensives.

The dispenser 1 contains the dispenser body 10, which has a front door 11.1 of the body (Fig. 1A) and a rear door 11.2 of the body (Fig. 1B), as well as connecting both doors of the body and covering the dispenser from three narrow sides, consisting of several parts part 12 of the case, which in the lower area on each side is made in the form of control keys 14, 15. The housing part is made of a composite material to ensure that the part that is on one end 60 in the area 13 is made rigid, while the two control keys that are on the side of the dispenser on the narrow sides are made movable so that so that it is possible to perform a pressing movement directed towards the body of the dispenser (see arrows). As an alternative, the housing part can also be made as a deformed hard shell pressed into the lower region so that the control keys are formed.

An electronic display 16 and control buttons 17, 18 are provided in the front door 11.1 of the housing. Control over taking T tablets is carried out using an electronic display. The control keys 14, 15 are used to select the menu item shown by the display, for example, to control the battery or the day of reception, the day of the pause and the number of pills still in the cartridge, as well as to choose whether the reception of pills should be interrupted.

In fig. 1B shows the back side of the dispenser 1. The back side includes a window 20 extending in the axial direction and which allows you to see the tablets contained in the cartridge.

For this purpose, the rear leaf 11.2 of the cartridge case in the area of the window, as well as the cartridge case must be made transparent, at least in the part visible through the window.

In the lower area of the dispenser 1, you can see part of the cartridge, namely, the lower cup 920 of the cartridge, which is flush with the dispenser body. In the lower bowl of the cartridge, the output hole 922 for tablets T is visible (fig. TA). In the front door 11.1 of the case, a cartridge ejection key 19 is inserted, which moves in the direction of the arrow in order to eject the cartridge from the dispenser when it is empty.

In fig. 2 shows a part of the dispenser 1 (without the outer casing), as well as the inserted cartridge 900 in the dispenser when viewed from the back side. The cartridge is inserted into the dispenser from below (see arrow), while the cartridge has a disconnecting device, part of which is the lower bowl 920 of the cartridge, and with the help of which the cartridge in the lower area of the dispenser adheres to the dispenser body (Fig. 1A). In addition, the cartridge contains a cartridge housing 930 in which the tablets T are located. This housing is formed by a front cartridge flap 933 and a rear cartridge flap (not shown), which for use in a dispenser preferably consists of a transparent material so that through the window 20 tablets could be seen on the back of the dispenser (Fig. 1B).

Inside, the dispenser 1 contains an internal frame 100 of the body, which essentially performs all the static functions of the dispenser. The inner frame of the case has, for example, a middle jumper 110 (hidden),

The side of which is cylindrically concave to receive the cartridge housing 930 (the front half of the cartridge housing is only partially visible). The concavity of this bridge, together with other (not shown here) structural elements of the dispenser, forms a receiving shaft (designated by reference numeral 150) into which the cartridge can be inserted into the dispenser from below. The receiving shaft is marked here only by a dotted line and is characterized by an oblong cavity.

In fig. C shows the lower part of the inner frame 100 of the dispenser 1 released from the outer casing when viewed from the front. A cartridge disconnect device 910 is shown on the lower narrow side of the dispenser, but in this case without the lower cup 920.

Therefore, visible here is a pill pusher 940 belonging to the release device which slides in and is housed in the pusher mount 950 and which has a through hole 942 which also serves as a receiving section for the pills T to be dispensed. In the first position, this receiving section is coaxial with the outlet opening of the lower bowl, so that the tablet in the receiving section can be dispensed to the outside. If the pill pusher is moved to the second position (left, see arrow), the receiving section is coaxial with the pill receiver formed by the cartridge housing 930 (not shown), so that in this position one pill can fall into the receiving section. In this position, the receiving section is closed downward by the lower cup 920 of the cartridge (not shown). In order to make this shift, the following structural elements are provided:

Control keys 14, 15 on the body 10 of the dispenser to control the dispenser 1 are pushed inward (Fig. 1A, see arrow). At the same time, they act on two transport levers, the right transport lever 210 and the left transport lever 220. Both of these transport levers have toothed rails 212 or 222 and through these toothed rails are in kinematic connection with the gear 230. The gear is installed on the inner frame 100 case. The right transport lever through the pressure spring 240 rests on the counter-support 102, so that this transport lever and, thereby, also the left transport lever, after actuation of the control keys, return to the initial position again, that is, the position in which both levers are pushed out (the first position). In addition, a sleeve 224 having a recess 226 is molded on the right transport lever. A leash projection is molded on the pill pusher 940 and fits into this recess. When the transport levers 210, 220 are pushed outwards by the force of the compression spring 240, the levers are in the unloaded (first) outward position, so that the pill pusher is in the (shown in Fig. 3) right position. In this position, the receiving section 942 in the pill pusher is coaxial with the outlet opening 922 in the lower bowl 920 of the cartridge. By actuating the control keys 14, 15, the transport levers are pressed inward and thus shift the pill pusher to the left (second position). Thereby, the receiving section moves to a position coaxial with the cartridge receiver, so that one pill from the receiver falls into the receiving section. When the control keys are released, the transport levers and, thereby, the receiving section, which is in the pusher, move to the right again under the action of the spring, so that the receiving section again falls into a position coaxial with the outlet opening. As a result, one tablet is dispensed from the dispenser.

In fig. 4 shows a T-pill filled cartridge 900 in section as viewed from the front. The cartridge has a disconnection device 910 with a lower cartridge cup 920 visible here, as well as a cartridge housing 930 consisting of a cartridge front flap (not shown) and a cartridge rear flap 932. The front flap of the cartridge and the rear flap of the cartridge form a cylindrical receiver, in which the pills are in the form of a stack. Between both flaps of the cartridge on one side (right) there is a slot that extends axially.

In the form shown, the cartridge 900 can be manipulated separately, that is, it can be used to refill the dispenser 1 in such a way that the end of the cartridge is inserted into the essentially cylindrical receiving shaft 150 in the dispenser and fixed there. For transportation and storage of an individual cartridge, it is mainly placed in a waterproof and airtight secondary packaging, for example, in a bag or blister.

In the housing 930 of the cartridge above the stack of tablets T there is a rater 960 of tablets, which can in principle freely move in the receiver of the cartridge in the axial direction (Fig. 4A). For this, the tablet reiter lever 961 of the reiter passes through a slot extending in the axial direction, between the front leaf 933 of the cartridge (not shown) and the rear leaf 932 of the cartridge. A pill dispenser rests on top of a stack of pills. However, the axial upward movement of the tablet rater is limited by the tolerance compensation plug 970. This plug is inserted into the receiver before the cartridge is filled with 900 T pills, and after the cartridge is filled, it is pressed against the pill stack and the pill rater. Because the tolerance compensation plug slides in the receiver with a friction lock, when the cartridge is manipulated outside the dispenser, it presses against the stack of pills and holds the stack together so that individual pills cannot slip or move relative to each other. Due to this, firstly, abrasion of the tablets is prevented, and, secondly, the fact that the tablets may stand up on the edge or at an angle during free movement. Due to this, tipping over and, thereby, skewing of tablets in the receiver is prevented. In order to achieve frictional sliding of the tolerance compensation plug 970, it has a main body 971, as well as two spring elements with locking protrusions 972, 972", which are adjacent to the inner wall of the cartridge body. In order to effectively perform frictional locking, the inner wall in the areas , in which the locking lugs contact the inner wall, has opposing ratchet tracks 975 that engage the locking lugs (see detailed view of Fig. 4A). These ratchet tracks are only about 2 cm long, because the tolerance compensation plug must keep the tablets tightly packed only when the cartridge is fully loaded during handling, so that the plug should enter into friction-locking connection with the inner wall of the cartridge body only in that area, in which should be compensated only arising due to the tolerance of individual tablets by the thickness of the variation of the stack height .

In fig. 5 shows a dispenser 1 without an outer casing when viewed from the rear side, containing a cartridge 900 filled with tablets T. The cartridge contains a tablet rater 960 sitting on a stack of tablets, having a rater lever 961 protruding from the cartridge body 930. On the tablet reiter sits a tolerance compensation plug 970 containing spring elements with locking projections 972 (one of the spring elements is shown here). The fixing protrusions of the spring elements are included in the ratcheting tracks 975.

In addition, the dispenser 1 contains a feed bugle 300 which covers the middle bridge 110 of the inner frame 100 of the housing and is movable along this bridge in the axial direction and is guided on it, for example, by means of a dovetail type guide formed by the side surfaces of the bridge and the shelves 311 , 312 bugels, or by fixing these shelves with the side surfaces of the bridge (fig. b).

In fig. 6 shows the internal frame 100 of the body with the feed pipe 300 when viewed from the back side of the dispenser 1. The feed pipe has two sleeves 315, 316, which are molded to the latter approximately at right angles to the shelves 311, 312. At the ends of these sleeves there are fasteners for springs 320, 330 of constant force on their respective one end. The springs of constant effort are fixed with their respective other ends in the lower part of the inner frame 100 of the body and wound there. Due to this, the upward movement of the feed screw in the axial direction can be achieved only against the force of the springs of constant force. However, as an alternative, the constant force springs can also be fixed in suitable fasteners, wound, for example, on its sleeves, on the feeding bushel, and their other ends can be fixed below on the inner frame of the housing.

When inserting the cartridge from below into the receiving shaft 150 (not shown here) in the dispenser 1 (arrow), passing through the axial slot between the rear leaf of the cartridge (not shown) and the front leaf 933 of the cartridge, the lever of the rater (Fig. 5) affects the lower side of the shelf 311 of the bugle 300 feeds and also moves the feed bugle up when inserting the cartridge. Because the 960 pill rater sits on top of the pill stack and the cartridge is primed when inserted, and the feed lug also moves up to the top end of the middle jumper. Due to this, both springs 320, 330 of a constant force are stretched, so that the feeding bushel is under downward spring tension. This tension is transmitted through the pill rater to the pill stack.

When inserting the cartridge 900 into the receiving shaft 150 of the dispenser 1, the cartridge is blocked in the dispenser. For this, the left locking lever 420 and the right locking lever 410 are provided for the cartridge. Locking levers are installed on the inner frame 100 of the body at the pivot points 415, 425. At the respective lower ends of the locking levers, locking protrusions 412, 422 are provided (Fig. 7, 7A, 7B). They lead into the corresponding lugs 981, 982 on the front flap 932 of the cartridge case (Fig. 7A, 7B) when the lower shelves of the locking levers and, thereby, the locking protrusions of the locking levers are folded inward (Fig. 5, see arrows pointing inward). This tilting movement is carried out due to the fact that when inserting the cartridge into the dispenser on the middle bridge 110 of the internal frame of the housing, the feed bar 300 moves up, and then in the upper region it slides along the surfaces 416, 426 of the run-up of the locking levers and, thereby, unclamps the locking levers at the top . Due to this, the upper shelves of the locking levers turn outward, and the lower shelves inward. At the same time, the spring levers 417, 427, which are formed above the corresponding pivot points on the locking levers, through the corresponding pivot points 418, 428, are pinched by the designated projections 419, 429 on the inner frame of the case, so that the locking levers are held in

From this position, there is no possibility of displacement (Fig. 5A). Therefore, the locking levers, after inserting a loaded cartridge, are fixed in the locked position, so that the cartridge can no longer be extracted without additional aids. This ensures that the cartridge, after being inserted and fixed in the dispenser, cannot be pulled out if the cartridge is fully loaded during insertion, because the feed bar moves upwards when inserting a loaded cartridge

C5 to the running surfaces of the locking levers and, thereby, moves them into the locked position. This lock remains until the cartridge is empty.

In order for the empty cartridge to be thrown out of the dispenser, an ejection mechanism is provided, which removes the blocking made by the locking levers. The details of this ejection mechanism are shown in figures 8A, 8B, 88, 8GI and left.

In order for the cartridge to be ejected, a free switching lever 500 is provided directly behind the ejecting pusher 600, which has an ejection key 19 (closed). The free shift lever is fixed in an essentially vertical position by means of a twisted bending spring 510 (Fig. 88, 8G). For this purpose, the free switching lever is mounted on the front leaf 11.1 of the housing in the grippers 121, 122, which are molded to the front leaf 11.1 of the housing, using the axes 520, 520". The free switching lever is rotatable in the support of the grippers (arrows in Fig. 8A, 8B, 88 , 8G), however, only against the force of the twisted bending spring.

The freeshift lever 500 locks the ejector pusher 600 and thereby the ejector key 19 such that the locking lugs 531, 532 (or alternatively only one single locking lug) are in the idle lever position switching in front of the respective protrusions 611, 612 (alternatively just in front of the single protrusion) of the ejector pusher and blocking the downward translational movement of the pusher (ejection blocking). In fig. 88 for this purpose, a free-shift lever-locked ejector pusher is shown, while the ejector pusher in FIG. 8G is unlocked and already moved down.

When the cartridge 900 is emptied as a result of the dispensing of T tablets, the feeding tube 300 in the dispenser 1 slides down (Fig. 8B). When the delivery bugle reaches its lowest position during the last pill in the cartridge, it acts on the lever 540 of the free shift lever 500 and overturns the latter with its lower end against the force of the twisted bending spring bo 510 forward (Fig. 8B, arrow). As a result, the free shift lever releases the pusher,

ejector 600 such that the blocking protrusions 531, 532 are pushed away from the respective protrusions 611, 612 of the ejector pusher.

The function of the locking levers 410, 420 when unlocking the cartridge 900 is shown in Fig. 8D. The cartridge lock is removed due to the fact that the ejector pusher 600 moves downwards by approximately 2 mm (arrow). At the same time, the ejecting pusher, with its running surfaces 551, 552, comes into contact with the lower shelves of the locking levers 410, 420, so that they are pressed outward (arrows). As a result, the locking protrusions 412, 422 of the locking levers are pressed outward and squeezed out of the lugs 981, 982 of the cartridge. Thus, the cartridge is released. By further shifting the ejector pusher downwards, the cartridge can be ejected downwards. For this purpose, the locking protrusions of the ejector pusher simultaneously act as the ejection protrusions because they act on the edge of the upper side of the lower cartridge cup 920 and press it downwards in a downward motion. Then the cartridge can be taken by hand and removed from the receiving shaft 150 of the dispenser 1. The ejecting pusher, after being actuated by the force of the spring, returns to its original position again. For this, a twisted bending spring 510 is used.

Dispenser 1 has an electronic display 16, as well as two electronic control buttons 17, 18 (Fig. 1A). The electronic display serves to show the number of T pills in the cartridge 900 as well as the pill status, i.e. whether or not the first 24-day intake phase has passed and, if passed, the number of days that have already passed in the second flexible phase reception In addition, it can be shown if a pill has not been taken within a certain time window during the intake phase. In addition, the display can also show how many days have already passed in the started phase without reception, if necessary. In addition, the display can show the battery status. With the help of the control keys, the transition to the phase without reception can be selected, as well as the selection of various menu items.

The dispenser 1 contains batteries 1010, 1020 (Fig. 2, 5) (as an alternative also only one battery), which should maintain the functionality of the dispenser 1 as long as possible without the need for replacement. Therefore, the dispenser for commissioning when the cartridge 900 is first inserted into the dispenser contains an initialization switch 710 located on the inner frame of the housing (Fig. 9).

This switch is formed by the lever 430 of the left locking lever 420 on its upper

From the shelf. When the cartridge is inserted, it pushes the upper shelf of the left locking lever outward, because the feed dog 300 slides on the running surface 426 along the upper shelf of the locking lever and at the same time squeezes the shelf outward (Fig. 5). At the same time, the shift lever formed on the left locking lever presses against the initialization switch and activates it. As a result of actuation of this switch, the electronics are initialized, which until now are in a rest position without consuming power, and thanks to the special design of the initialization switch, it remains on even after the cartridge is removed.

Simultaneously with the initialization of the electronics, when the cartridge 900 is first inserted into the dispenser, a second switch (not shown) is activated, which is located near the initialization switch 710, which remains on only while the upper shelf of the right lock is pressed outward, that is, while the cartridge remains in the dispenser. After pulling out the cartridge, this second switch turns off again as a result of turning the upper shelf of the locking lever 420 inward. This second switch sends a signal to the electronics that there is a cartridge in the dispenser. Thus, the number of tablets T present in the dispenser can be calculated accordingly, namely, with the help of the task that a certain number of tablets, for example 30 tablets, are always present in a fully filled cartridge, and also with the help of a signal transmitted to the electronics, by means of which every withdrawal of a pill from the dispenser is registered. In addition, when removing an empty cartridge from the dispenser and inserting a new filled cartridge with the help of another signal from the second switch, the electronics receive information that the fully filled cartridge is now in the dispenser again.

The next signal, which registers the withdrawal of the tablet T from the dispenser 1, is generated by the third switch (not shown), which is in the area of the transport lever 210, 220, and which is turned on each time the transport lever is actuated and at the same time generates this next signal.

In addition, the dispenser 1 contains a fourth switch (not shown) in the lower area of the receiving shaft 150, which registers the slippage of the feed bugle 300 and is transmitted to the electronics as an additional signal. This fourth switch serves to signal to the electronics the remaining number of tablets in the cartridge shortly before the final emptying of the cartridge 900, for example, when there are at least five T tablets in the cartridge. This is determined by the precise spatial positioning of this fourth switch in the receiving shaft, so that the fourth switch is actuated when a tablet is withdrawn only if there is still a pre-determined number of tablets in the cartridge. The fact is that this check count may be necessary to correctly show the consumer how many pills are still in the cartridge, if there are only a few.

This ensures that an incorrect assumption is not made about the number of tablets remaining, as this could be critical if the consumer is not alerted in time that the cartridge is empty. This precaution is beneficial if the pill cartridge cannot be reliably maintained, including by all control measures in the cartridge filling sequence. The fact is that the height of an individual tablet has a tolerance, so the height of a stack of tablets can also vary. However, in any case, the consumer can see through the window 20 in the rear door 11.2 of the case whether there are still pills in the cartridge.

It is understood that the examples and embodiments described herein are for illustrative purposes only, and that various modifications and changes to the examples and embodiments, as well as combinations of the features otherwise described in this application, are readily identifiable to those skilled in the art, and are contained in the content that disclosed, the invention described here, as well as in the scope of protection of the claims. At the same time, all patents and patent applications referred to here are included in the content of the disclosure of the application.

Claims (2)

FORMULA OF THE INVENTION 1. A cartridge (900) which is inserted into a medicine dispenser (1) for portions (T) of a solid substance medicine and is made with a receiver for placing portions (T) of a medicine, the cartridge (900) having a disconnection device (910), which is designed to dispense specified portions (T) of the medicinal product, and which contains a movable device (940) for separating the specified portion (T) of the medicinal product from the receiver and for dispensing from the dispenser (1) of medicinal products, when in this case, the disconnecting device (910) is designed to establish a kinematic connection with the device (14, 220, 224, 226; 15, 210, 230) provided in the dispenser (1) of medicinal products (14, 220, 224, 226; 15, 210, 230) control for the disconnecting device (910) , and at the same time, portions of the medicinal product (T) during separation, as well as their dispensing or release from the dispenser, do not touch the dispenser or its parts. 2. The cartridge (900) according to claim 1, characterized in that the cartridge (900) is cylindrical and has a cylindrical receiver for placing tablets in a columnar arrangement, and the cartridge is designed to dispense portions (T) of the medicinal product in the direction of the longitudinal axis cylindrical cartridge (900). Z. The cartridge (900) according to claim 2, which is characterized in that the device for separating and dispensing portions (T) of the medicinal product contains a pusher (940) made with the possibility of movement perpendicular to the longitudinal axis of the cylindrical cartridge (900). 4. The cartridge (900) according to claim 3, characterized in that the disconnecting device (910) is located at one end of the cylindrical cartridge (900). 5. Cartridge (900) according to one of paragraphs With or 4, which is characterized in that the pusher (940) is made with the possibility of movement relative to the receiver in the cartridge (900) between two positions of movement perpendicular to the longitudinal axis of the cylindrical cartridge (900). 6. Cartridge (900) according to one of claims 3-5, which is characterized in that the pusher (940) has a receiving section (942) open on both sides in the direction of the longitudinal axis of the cylindrical cartridge for a given portion (T) of the medicine. 7. Cartridge (900) according to claim 6, characterized in that the decoupling device (910) also includes a lower cup (920), and that the lower cup (920) is offset relative to the longitudinal axis of the cartridge and is located coaxially with the receiving section ( 942) outlet (922) in one of the two positions of movement of the pusher (940). 8. Application of the cartridge (900) according to one of claims 1-7 for storing portions (T) of medicines. 9. Application according to claim 8, which differs in that the portions (T) of the medicinal product are hormonal preparations. 10. A dispenser (1) of medicines for portions (T) of a solid substance medicine, which is designed to accommodate a replaceable cartridge (900), while the cartridge (900) has a receiver for portions (T) of the medicine, as well as a disconnecting a device for dispensing specified portions of a medicinal product, while the dispenser (1) of medicinal products has at least one device (14, 220, 224, 226; 15, 210, 230) control for the decoupling device (910), as well as means for establishing a kinematic connection between at least one control device and the movable device (940) on the decoupling to the connecting device (910) and serves to separate the given portion (T) of the medicinal product from the receiver and to dispense the medicinal products from the dispenser (1), and at the same time the portion of the medicinal product (T) upon disconnection, as well as their dispensing or released from the dispenser, do not touch the dispenser or its parts. 11. Dispenser (1) of medicinal products for servings (T) of solid medicinal product according to claim 10 with a replaceable cartridge (900) according to one of claims 1-7 contained in the dispenser (1). 12. Application of the dispenser (1) of medicinal products according to claim 11 for storing and dispensing portions (T) of medicinal products, which is characterized by the fact that the portions of the medicinal product are hormonal preparations. and 13 IR? DE, 1 y A SHE zh Y y ia 7 U t Y i (1-7 х h ) / Й i 1" - (3 18 и ' Е - -e- А-Ж1 -- with vi ikh ke и Е Й "what | ho Z vd m 970 9/2 OA t t 191 u. y y "o 91 and FiLA Fig. 16 900 4 ny Shi 1 p ke TOP /7 / and I V t 930 7) in S KM / / / That's 700 KSO Te GE. ШЭ ей I «ШЩШ ЗЕ for | in, 150 I in still i-. B BA. Gu and Z as ps as Renault ANA and voi WE and pev t sho. 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