UA109867C2 - Замещенные соединения пиразола как антагонисты рецепторов лизофосфатидной кислоты (lpar) - Google Patents

Замещенные соединения пиразола как антагонисты рецепторов лизофосфатидной кислоты (lpar)

Info

Publication number
UA109867C2
UA109867C2 UAA201500427A UAA201500427A UA109867C2 UA 109867 C2 UA109867 C2 UA 109867C2 UA A201500427 A UAA201500427 A UA A201500427A UA A201500427 A UAA201500427 A UA A201500427A UA 109867 C2 UA109867 C2 UA 109867C2
Authority
UA
Ukraine
Prior art keywords
lpar
antagonists
lysophosphatidic acid
pyrazole compounds
substituted pyrazole
Prior art date
Application number
UAA201500427A
Other languages
English (en)
Russian (ru)
Ukrainian (uk)
Inventor
Стівен Дімс Гебріель
Метью Майкл Гамільтон
Імінь Цянь
Ачютарао Сіддурі
Original Assignee
Ф. Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48656033&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA109867(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ф. Хоффманн-Ля Рош Аг filed Critical Ф. Хоффманн-Ля Рош Аг
Publication of UA109867C2 publication Critical patent/UA109867C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
UAA201500427A 2012-06-20 2013-06-17 Замещенные соединения пиразола как антагонисты рецепторов лизофосфатидной кислоты (lpar) UA109867C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261661958P 2012-06-20 2012-06-20
PCT/EP2013/062458 WO2013189862A1 (en) 2012-06-20 2013-06-17 Substituted pyrazole compounds as lpar antagonists

Publications (1)

Publication Number Publication Date
UA109867C2 true UA109867C2 (ru) 2015-10-12

Family

ID=48656033

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201500427A UA109867C2 (ru) 2012-06-20 2013-06-17 Замещенные соединения пиразола как антагонисты рецепторов лизофосфатидной кислоты (lpar)

Country Status (22)

Country Link
US (1) US20150259295A1 (pt-PT)
EP (1) EP2864294A1 (pt-PT)
JP (1) JP2015520201A (pt-PT)
KR (1) KR20150011003A (pt-PT)
CN (1) CN104411690A (pt-PT)
AU (1) AU2013279510A1 (pt-PT)
BR (1) BR112014031108A2 (pt-PT)
CA (1) CA2869602A1 (pt-PT)
CL (1) CL2014003242A1 (pt-PT)
CO (1) CO7160077A2 (pt-PT)
CR (1) CR20140516A (pt-PT)
EA (1) EA201492283A1 (pt-PT)
HK (1) HK1206341A1 (pt-PT)
IL (1) IL236091A0 (pt-PT)
IN (1) IN2014DN09347A (pt-PT)
MA (1) MA37765A1 (pt-PT)
MX (1) MX2014014105A (pt-PT)
PE (1) PE20142445A1 (pt-PT)
PH (1) PH12014502364A1 (pt-PT)
SG (1) SG11201407229UA (pt-PT)
UA (1) UA109867C2 (pt-PT)
WO (1) WO2013189862A1 (pt-PT)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8975235B2 (en) 2011-03-20 2015-03-10 Intermune, Inc. Lysophosphatidic acid receptor antagonists
US10000459B2 (en) 2013-03-15 2018-06-19 Epigen Biosciences, Inc. Heterocyclic compounds useful in the treatment of disease
RU2689315C2 (ru) 2014-06-27 2019-05-27 Убе Индастриз, Лтд. Соль гетероциклического соединения, замещенного галогеном
KR20200100712A (ko) * 2017-12-19 2020-08-26 브리스톨-마이어스 스큅 컴퍼니 Lpa 길항제로서의 피라졸 n-연결된 카르바모일 시클로헥실 산
CN111434655A (zh) * 2019-01-15 2020-07-21 武汉朗来科技发展有限公司 溶血磷脂酸受体拮抗剂及其制备方法
JP7431961B2 (ja) 2019-11-15 2024-02-15 ギリアード サイエンシーズ， インコーポレイテッド Ｌｐａ受容体アンタゴニストとしてのトリアゾールカルバメートピリジルスルホンアミド及びその使用
KR20230019880A (ko) 2020-06-03 2023-02-09 길리애드 사이언시즈, 인코포레이티드 Lpa 수용체 길항제 및 이의 용도
AU2021285747A1 (en) 2020-06-03 2023-01-19 Gilead Sciences, Inc. LPA receptor antagonists and uses thereof
TW202400561A (zh) * 2021-05-11 2024-01-01 美商基利科學股份有限公司 Lpa受體拮抗劑及其用途
US11939318B2 (en) 2021-12-08 2024-03-26 Gilead Sciences, Inc. LPA receptor antagonists and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2005063241A1 (ja) * 2003-12-26 2007-07-19 小野薬品工業株式会社 ミトコンドリアベンゾジアゼピン受容体介在性疾患の予防および／または治療剤
TW200827346A (en) 2006-11-03 2008-07-01 Astrazeneca Ab Chemical compounds
US20090036425A1 (en) 2007-08-02 2009-02-05 Pfizer Inc Substituted bicyclolactam compounds
GB2466121B (en) * 2008-12-15 2010-12-08 Amira Pharmaceuticals Inc Antagonists of lysophosphatidic acid receptors
GB2470833B (en) * 2009-06-03 2011-06-01 Amira Pharmaceuticals Inc Polycyclic antagonists of lysophosphatidic acid receptors
WO2011017350A2 (en) * 2009-08-04 2011-02-10 Amira Pharmaceuticals, Inc. Compounds as lysophosphatidic acid receptor antagonists
BR112013014019A2 (pt) * 2010-12-07 2016-09-13 Amira Pharmaceuticals Inc antagonistas do receptor do ácido lisofosfatídico e seus usos
US8975235B2 (en) * 2011-03-20 2015-03-10 Intermune, Inc. Lysophosphatidic acid receptor antagonists
WO2012138648A1 (en) * 2011-04-06 2012-10-11 Irm Llc Compositions and methods for modulating lpa receptors

Also Published As

Publication number Publication date
SG11201407229UA (en) 2014-12-30
US20150259295A1 (en) 2015-09-17
MX2014014105A (es) 2015-03-05
IL236091A0 (en) 2015-02-01
KR20150011003A (ko) 2015-01-29
EP2864294A1 (en) 2015-04-29
PH12014502364A1 (en) 2015-01-12
CL2014003242A1 (es) 2015-03-20
JP2015520201A (ja) 2015-07-16
EA201492283A1 (ru) 2015-04-30
BR112014031108A2 (pt) 2017-06-27
CA2869602A1 (en) 2013-12-27
PE20142445A1 (es) 2015-01-28
CO7160077A2 (es) 2015-01-15
IN2014DN09347A (pt-PT) 2015-07-17
AU2013279510A1 (en) 2014-10-16
WO2013189862A1 (en) 2013-12-27
HK1206341A1 (en) 2016-01-08
CN104411690A (zh) 2015-03-11
MA37765A1 (fr) 2017-04-28
CR20140516A (es) 2014-12-01

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