UA108473C2 - Conjugates, their preparation and therapeutic use - Google Patents
Conjugates, their preparation and therapeutic useInfo
- Publication number
- UA108473C2 UA108473C2 UAA201200825A UAA201200825A UA108473C2 UA 108473 C2 UA108473 C2 UA 108473C2 UA A201200825 A UAA201200825 A UA A201200825A UA A201200825 A UAA201200825 A UA A201200825A UA 108473 C2 UA108473 C2 UA 108473C2
- Authority
- UA
- Ukraine
- Prior art keywords
- group
- alkyl group
- phenyl core
- alkyl
- substituent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/08—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and more than one oxygen atom
Abstract
The invention relates to a targeting agent, to which at least one cryptophycin is attached of the formula (I), where: R1 is a halogen atom and R2 is an -OH group, an acyl group derived from an amino acid AA or a (C1-C4)alkanoyloxy group; or else R1 and R2 together form an epoxy unit; AA denotes a natural or artificial amino acid; R3 is a (C1-C6)alkyl group; R4 and R5 are both H or together form a CH=CH double bond between C13 and C14; R6 and R7 are, independently from one another, H or a (C1-C6)alkyl group; R8 and R9 are, independently from one another, H or a (C1-C6)alkyl group; R10 is at least one substituent of the phenyl core selected from among: H, an -OH group, (C1-C4)alkoxy, a halogen atom or a -NH2, -NH(C1-C6)alkyl, or -N(C1-C6)alkyl group; R11 is at least one substituent of the phenyl core selected from among H or a (C1-C4)alkyl group; the targeting agent and the cryptophycin derivative being covalently bonded, the bond being located at the ortho- (o), meta- (m), or para- (p) position of the phenyl core containing the CR1 unit.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0903170A FR2947269B1 (en) | 2009-06-29 | 2009-06-29 | NEW ANTICANCER COMPOUNDS |
| FR0905651A FR2947271B1 (en) | 2009-06-29 | 2009-11-25 | NEW ANTICANCER COMPOUNDS |
| PCT/FR2010/050986 WO2011001052A1 (en) | 2009-06-29 | 2010-05-20 | Novel conjugates, preparation thereof, and therapeutic use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA108473C2 true UA108473C2 (en) | 2015-05-12 |
Family
ID=65686635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201200825A UA108473C2 (en) | 2009-06-29 | 2010-05-20 | Conjugates, their preparation and therapeutic use |
Country Status (1)
| Country | Link |
|---|---|
| UA (1) | UA108473C2 (en) |
-
2010
- 2010-05-20 UA UAA201200825A patent/UA108473C2/en unknown
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