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Application filed by Хелсінн Хелткеа СаfiledCriticalХелсінн Хелткеа Са
Priority claimed from PCT/IB2010/003106external-prioritypatent/WO2011061622A1/en
Publication of UA105817C2publicationCriticalpatent/UA105817C2/en
A method of treating nausea and vomiting in a patient in need thereof, comprising: oral administering to said patient of palonosetron or a pharmaceutically acceptable salt thereof in amount of about 0.25 to 0.75 mg and netupinant or a pharmaceutically acceptable salt thereof in amount of about 200 to about 400 mg. the invention further relates to an orally administered dosage form comprising a combination of palonosetron and an NK1 antagonist, or a pharmaceutically acceptable salt or prodrug thereof, comprising: a) an outer shell; b) one or more NK1 antagonist units housed within said outer shell, each comprising said netupitant or pharmaceutically acceptable salt or prodrug thereof and one or more pharmaceutically acceptable excipients; and c) one or more palonosetron units housed within said outer shell, each comprising said palonosetron or pharmaceutically acceptable ester or prodrug thereof and one or more pharmaceutically acceptable excipients; wherein said dosage form comprises (3S)-3-[(3aS)-1-oxo- 2,3,3a,4,5,6-hexahydro- 1H- benzo[de] isoquinoline-2-yl]-1-azoniabicyclo[2.2.2]octan-1-olate in an amount that does not exceed 3 wt. % .
UAA201207337A2009-11-182010-11-18Normal;heading 1;heading 2;heading 3;COMPOSITIONS FOR TREATING CENTRALLY MEDIATED NAUSEA AND VOMITING
UA105817C2
(en)