Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Онкомед Фармасьютикалз, Инк.filedCriticalОнкомед Фармасьютикалз, Инк.
Priority claimed from PCT/US2009/003994external-prioritypatent/WO2010005566A2/en
Publication of UA101671C2publicationCriticalpatent/UA101671C2/en
The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
UAA201101441A2008-07-082009-07-08Notch-binding agents and antagonists and methods of using thereof
UA101671C2
(en)