UA101671C2 - Notch-binding agents and antagonists and methods of using thereof - Google Patents

Notch-binding agents and antagonists and methods of using thereof

Info

Publication number
UA101671C2
UA101671C2 UAA201101441A UAA201101441A UA101671C2 UA 101671 C2 UA101671 C2 UA 101671C2 UA A201101441 A UAA201101441 A UA A201101441A UA A201101441 A UAA201101441 A UA A201101441A UA 101671 C2 UA101671 C2 UA 101671C2
Authority
UA
Ukraine
Prior art keywords
methods
notch
antagonists
present
binding agents
Prior art date
Application number
UAA201101441A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Остин Л. Герни
Тимоти Чарльз Геуй
ван дер Хорст Эдвард Тайн Хтун
Аарон Кен Сато
Юань Чинг Лю
Морин Фитч Брунс
Джон А. Льюики
Original Assignee
Онкомед Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Онкомед Фармасьютикалз, Инк. filed Critical Онкомед Фармасьютикалз, Инк.
Priority claimed from PCT/US2009/003994 external-priority patent/WO2010005566A2/en
Publication of UA101671C2 publication Critical patent/UA101671C2/en

Links

Abstract

The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
UAA201101441A 2008-07-08 2009-07-08 Notch-binding agents and antagonists and methods of using thereof UA101671C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7909508P 2008-07-08 2008-07-08
PCT/US2009/003994 WO2010005566A2 (en) 2008-07-08 2009-07-08 Notch-binding agents and antagonists and methods of use thereof

Publications (1)

Publication Number Publication Date
UA101671C2 true UA101671C2 (en) 2013-04-25

Family

ID=51950348

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201101441A UA101671C2 (en) 2008-07-08 2009-07-08 Notch-binding agents and antagonists and methods of using thereof

Country Status (1)

Country Link
UA (1) UA101671C2 (en)

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