UA101291U - BIOLOGICALLY ACTIVE SUPPLEMENT WITH COMPLEX IMMUNOSTIMULATING, ANTI-VIRUS, ANTI-INFLAMMATORY AND ANTIBACTERIAL ACTION - Google Patents

Abstract

Biologically active additive with complex immunostimulatory, antiviral, anti-inflammatory and antibacterial action contains honey bee, royal jelly, bee pollen and animal fat. Additionally contains oregano oil and Indian hemp oil, as animal fat used goose fat, badger fat, bear fat and dog fat in equal proportions, and honey bee is used as mountain honey.

Description

The useful model belongs to products of increased biological activity of a wide range of preventive and therapeutic action, which are made on the basis of beekeeping products and raw materials of plant and animal origin. The proposed biologically active food additive is intended for internal use and provides an expansion of the arsenal of agents that have complementary antiviral and anti-inflammatory properties, stimulate the immune system, and increase the vitality of the body.

A well-known anti-inflammatory, wound-healing and regenerating agent (Patent of Ukraine for the invention

Мо 51472, МПК АЕЙ1К 9/12, publ. 11/15/2002, Byul Mo 11, 2002), containing active active substances of plant origin and a base, in which beef fat, goose fat and beeswax are used as a base, and extracts of a mixture of medicinal plants are used as an active active substance the following ratio of components, mass: medicinal chamomile (Maipsapa hestia) 10-15; three-part sequence (Videpe5 Shirapiye) 10-15; common yarrow (Aspiea itIPeitm/p) 10-15; Medicinal black root (Supodioszite oiisipaIe) 30-35; beeswax 2-3; goose fat 10-15; beef fat - the rest. Although this agent has a wide spectrum of pharmacological effects, has anti-inflammatory, wound-healing and regenerating properties, it is intended for external use.

A well-known biologically active food additive (Russian Patent for the invention No. 2253328, IPC A231I 1/30,

A2311/325, A2307/00, publ. 10.03.2004) which is made in the form of an aqueous emulsion of the fat of marine organisms and contains bee honey and a gel-forming agent, in which the fat of marine organisms contains the fat of marine mammals with a content of polyunsaturated fatty acids "omega-3" at least 20 wt.95, as a gel-forming agent contains pectin isolated from seaweed and/or herbs, with the following composition of ingredients, wt. 90: bee honey - 15-30, marine mammal fat - 4-12, pectin - 0.5-4.5, water - other. As pectin, sodium alginate is used - a polysaccharide obtained mainly from marine brown algae, mainly kelp, fucus, arthrotamius. The chosen ratio of components does not provide a wide range of action of the declared additive, namely it does not have anti-inflammatory, antiseptic, antiviral action.

In addition, the long-term joint presence of polyunsaturated fatty acids, honey and sodium alginate in it does not affect the quality of nutritional supplements in the best way, since they are substances of different nature. They have different physical and chemical properties, these substances are quite complex

To be combined simultaneously in one drug, without reducing the quality of individual components and without shortening the shelf life. And fish oils are extremely sensitive to the presence of water. In the presence of water, the hydrolysis process accelerates, the total content of free fatty acids increases, the mechanisms of further fat degradation are triggered, which leads to a deterioration in the quality of the target product and a reduction in its shelf life. The useful components of honey in this supplement are completely neutralized in the process of preparing a fat-honey mixture, in which bee honey and marine mammal fat are heated in separate containers to 100-120°C while stirring and mixed at the same temperature.

From the state of the art, a biologically active food additive is known (invention patent of the Russian Federation No. 2197868, IPC A2gZ11/30, A2311/29, Ag2311/08, published on February 10, 2003) which contains natural flower honey, royal jelly, Chinese lemongrass, ginseng, flower pollen, walnut kernels, Rhodiola rosea tincture, Lewzea safflower tincture, Eleutherococcus tincture. Although this remedy is characterized by a balanced protein-carbohydrate composition and has an increased energy value, the above remedy is contraindicated for people suffering from cardiovascular diseases, especially the elderly, because it contains Eleutherococcus, which can lead to an increase in blood pressure. The presence of alcohol tincture of Rhodiola rosea in the composition of the well-known food additive makes it possible to use this product for people with liver diseases and for pregnant and nursing women.

A well-known remedy for apitherapy and apiprophylaxis (Russian Patent No. 2033798, IPC Ab1KZ5/64,

AbI1IKZ5/78, A23I1/076, publ. 04/30/1995), which contains honey, propolis preparation, dry mummy extract and medicinal plant extract, which additionally contains antler extract and royal milk, and as a propolis preparation, its bioflavonoids with the following component ratios, mass: propolis bioflavonoids - 5.0 , extracts of medicinal plants - 10, dry mummy extract - 1, antler extract - 2, royal jelly - 1, honey up to 100. The product contains about 8095 honey in its composition, which does not contribute to the potentiation of the action of the active components of the claimed product.

A known biologically active admixture (Patent of Ukraine Mo 9413, IPC A2311/03, publ. 15.09.2005, Byul. Mo 9, 2005), which is made on the basis of animal raw materials, in which badger fat is used as an animal raw material in the form of a solution. In addition, vegetable admixtures were added to badger fat, and mint was used as a vegetable admixture. In addition, honey is added to badger fat. BAD, which is made on the basis of only badger fat, has many contraindications. It is known that badger fat can cause side effects. Like any fat, it can cause nausea, vomiting and diarrhea. A large number of biologically active substances creates conditions for the development of allergic reactions. In addition, beekeeping products, which are biologically active substances in the composition of this dietary supplement, occupy such an insignificant mass share that their influence on the general state of the body when taking dietary supplements is insignificant.

It is known that oregano essential oil is used as a prophylactic agent that helps increase life expectancy (Russian Patent No. 2475258, IPC Ab1K36/53, Ab1R43/00, published on February 20, 2013). The known application has a narrow effect, namely intended to increase life expectancy.

From the state of the art, the applicant did not find any similar mixtures to the claimed composition.

The components that make up the claimed product are known, but their claimed composition is not described in the patent and scientific and technical literature.

The basis of a useful model is the task of creating a new biologically active supplement with a complex immunostimulating, antiviral, anti-inflammatory and antibacterial effect, which is made on the basis of beekeeping products and raw materials of plant and animal origin, which, thanks to the introduction of new components and the selection of their ratio, provides a pronounced immunostimulating effect and suitable for long-term use without unwanted side effects and provides a wide range of preventive and health-improving effects on the human body.

The task is solved by offering a biologically active supplement with a complex immunostimulating, antiviral, anti-inflammatory and antibacterial effect, containing bee honey, royal jelly, bee pollen and animal fat, which, according to a useful model, additionally contains oregano oil and Indian hemp oil , goose fat, badger fat, bear fat and dog fat are used as animal fat in equal proportions, and mountain honey is used as bee honey in the following proportions, mass. for: mountain honey 40-49 bee pollen 10-15 goose fat 9-10 badger fat 9-10 bear fat 9-10 dog fat 9-10 royal jelly 1-3 oregano oil 0.2-0.4 Indian hemp oil rest.

The quantitative and qualitative composition of the declared dietary supplement was determined experimentally and ensures optimal pharmacological and technological properties of the proposed biological

Co) active additive.

As you know, oil of oregano (Ogidapyt ucidage) contains calcium, magnesium, zinc, iron, potassium, copper, boron, manganese and vitamins C, A (beta-carotene), niacin. Essential oil from motherwort flowers contains thymol, sesquiterpenes, free alcohols, phytoncides. Oregano also contains essential oils (up to 0.5 95), thymol, carvacrol, tannins and rosmarinic acid. Thanks to this, the motherboard has high antimicrobial activity. Carvacrol treats fungal infections, kills parasites such as giardia (small worms that live in the small intestine and gall bladder). Due to the introduction of oregano oil into the composition of the proposed supplement, its antimicrobial, antiviral, antiseptic effects and the possibility of use against parasites in the body are increased.

As you know, the composition of hemp oil includes: vitamins VI, B2, VZ, Vb, C and E; phosphorus; magnesium; potassium; calcium; sulfur; zinc; iron and other. Hemp oil is widely used for various skin diseases such as psoriasis, eczema, dermatitis, for wounds that do not heal for a long time, cuts, ulcers, abscesses for quick recovery. Hemp oil serves as an excellent antiseptic and anti-inflammatory agent, increases the body's immune functions. Its use with dry or, conversely, too oily skin restores the protective function of the skin, regulates the work of the sebaceous glands, and also normalizes the composition of their secretion, has a regenerating and moisturizing effect, and improves the complexion. Also, the general resistance of the body to any viruses and bacteria increases significantly. The inclusion of hemp oil in the composition of the proposed supplement provides an increase in its anti-inflammatory effect and an expansion of its scope of application, for example, to improve immunity.

As you know, goose fat contains most of the fatty acids necessary for the human body, it contains: omega-3 acid, oleic, palmitic, linoleic, linolenic, stearic, myristic and others, which ensure the normal course of all metabolic processes, help strengthen immunity, accelerate tissue regeneration. The main components of goose fat are triglycerides of oleic and linoleic acids. In addition, goose fat includes: minerals: magnesium, sodium, selenium, zinc, copper; vitamins: B1, B2,

VZ, B5, Vb, B12, E, RR and others. The unique vitamin and mineral composition of goose fat helps to strengthen the immune system of the human body. In addition, regular consumption of goose fat contributes to the stabilization of digestive and, in addition, metabolic processes. Experts recommend using goose fat as a preventive measure during the season of colds, as well as with spring vitamin deficiency. The described composition of goose fat and, accordingly, its properties led to its inclusion in the composition of the proposed dietary supplement (in the specified amount).

It is known that the composition of badger fat includes rare fatty acids omega Z and omega 6, irreplaceable linoleic and linolenic acids - polyunsaturated fatty acids, vitamins (A, group B), macro- and microelements, and other substances. Badger fat has anti-inflammatory, immunostimulating, antiatherogenic effects. When ingested, badger fat is absorbed by 100 95 in human blood, enriching it with vitamins A, B2, B5, Bb, B12, B, K, PP, carotene, tocopherol, carotenoids, folic acid, trace elements, minerals and organic acids necessary for the body. . When badger fat is taken internally, protein metabolism is enhanced, the body's immunity increases, and the correctness of the hematopoietic system is regulated. Badger fat has a bactericidal effect on tubercle bacilli. The secretory activity of the stomach and intestines is normalized, the emotional tone increases. Purulent processes are extinguished, fistulas and foci are closed, wounds are cleansed and the body begins to recover. All this led to the inclusion of this component in the composition of the new dietary supplement in the specified ratio.

A rather valuable component of the proposed supplement is bear fat. It is known that bear fat is superior to badger fat in a number of indicators. First of all, because the bear eats more diverse food (berries, nuts, honey, ants, fish, meat) and its internal endocrine system works better than that of any other animal. Bear fat contains: proteins, nucleic acids, triterpene glycosides, ginsenosides (panaxosides), cytamines

Zo (thymusamines, pancramins, bronchialamines, cerebramines, renisamines, ventramines, hepatamine, etc.), vitamins A, B groups (B1, B2, B3, B4 (choline), B12), E, poly- and monounsaturated fatty acids (in including Omega-3, Omega-6 and Omega-9), macro- and microelements and other substances useful for the human body. Cytamines, which are contained in bear fat, contribute to the improvement of metabolism and energy at the cellular level, helping the cells of those tissues to most effectively absorb the nutrients necessary for their full functioning (for example, thymusamines present in bear fat at the cellular level regulate the activity of the thymus gland , which is "responsible for immunity", pancramins regulate the functions of the pancreas, bronchialamines affect the work of the organs of the respiratory system, hepatamine is a bioregulator of liver functions, renisamines are important for the work of the kidneys, and ventramines have a positive effect on the state of the stomach). In general, bear fat helps to improve metabolic processes in the body; increases the adaptogenic capabilities of the human body in conditions of stress and the influence of adverse environmental factors; helps strengthen immunity, increases the body's resistance to infectious disease agents, has a bactericidal effect, prevents and eliminates the development of inflammatory processes (the anti-inflammatory effect of bear fat is largely associated with the presence in its composition of Omega-3 and Omega-b6 fatty acids, vitamins A and IS); helps increase physical and mental performance; activates tissue regeneration processes, has a protective and enveloping effect on mucous membranes of the gastrointestinal tract affected by the erosive-ulcerative process; improves digestion, compensates for impaired enzyme formation in case of poor nutrition; has a hepatoprotective effect (protects the liver from the action of toxins and other harmful substances). The described properties of bear fat led to its inclusion in the proposed dietary supplement (in the indicated ratio).

Another valuable component of the proposed dietary supplement is dog fat. Dog fat is characterized by a high content of cytamine, polyunsaturated and monounsaturated fatty acids, macro- and microelements and vitamins (vitamins A, E and group B). Easily absorbed by the human body, it has a bactericidal, immunomodulatory and general strengthening effect, dog fat has a positive effect on the functional state of the bronchi, lungs and upper respiratory tract, which is why it has long been and traditionally used as an auxiliary natural remedy in the treatment of such diseases as pulmonary tuberculosis, pneumonia , bronchitis, laryngotracheitis, laryngitis, silicosis of the lungs. Dog fat accelerates the processes of granulation and epithelization of damaged skin, prevents the development of inflammatory processes. The described properties of dog fat led to its inclusion in the proposed dietary supplement (in the indicated ratio).

In the claimed dietary supplement, the quantitative content of the components is selected in such a way that it is dominated by beekeeping products, the properties of which are known from various sources. For example, it is known that mountain honey has exceptional taste qualities. It is collected in ecologically clean corners from high mountain honey plants. Its composition is filled with more than 40 types of herbs and plants, including hawthorn, acacia, thistle, rose hip, cherry and others, which have healing properties. Alpine honey is able to restore the immune system well, and also increases the body's ability to resist viral and infectious diseases. The use of honey allows you to remove both internal and external inflammatory processes in the human body.

The composition of royal jelly is also known, which is diverse, but it is dominated by proteins and vitamins. Milk contains all the main substances necessary for the construction and existence of a living organism: proteins, fats, carbohydrates, vitamins, amino acids, enzymes, fatty acids and hormone-like substances. Natural milk contains up to 18 95 protein substances, from 9 to 18 95 carbohydrates, from 1.73 to 5.68 95 fats and more than 1 95 mineral salts. 22 amino acids were found in the protein fraction of royal jelly: arginine, asparagine, aspartic acid, valine, glycocol, glutamic acid, glutamine, lysine, leucine, methionine, oxypyrroline, proline, threonine, tryptophan, phenylalanine, histidine, cysteine. This composition makes it a high-quality nutritious and biologically active product. Some vitamins have been found in milk that add even more value to it. The composition of vitamins in royal jelly (in milligrams per 1 g of milk): vitamin B (thiamine, aneurin) from 1.2 to 1.3; B2 (riboflavin, lactoflavin) from 6 to 8; pyridoxine, dermin from 2 to 10; PP (nicotinic acid); B (nicotinamide) from 48 to 125: folic acid (vitamin B) from 0.5 to 2.2; vitamin H (biotin) - 1.6-4; vitamin B (pantothenic acid) - 180-200; ascorbic acid (vitamin C) - 2-4, B12 (cyanocobalamin) - 150. The main source of vitamins in royal jelly is flower pollen. Bee royal jelly is successfully used for the prevention of the most complex diseases of various orientations. Thanks to its use, physical fatigue and nervous tension are reduced, strength is restored, appetite, sleep, memory improve, and work capacity increases. It contributes to the strengthening of the body's resistance to various infections, increases vitality, and improves well-being

From the whole. In addition, the use of royal jelly contributes to the establishment of blood pressure, lowering the level of sugar in the blood, as well as increasing the recovery effect after a myocardial infarction.

And bee pollen contains all the necessary amino acids that a person must get with food, since the body itself cannot synthesize them. 27 trace elements were found in it, the most important of which are potassium, which is necessary to support the work of the heart muscle, as well as iron, copper and cobalt. Bee pollen also contains calcium, phosphorus, magnesium, zinc, iodine, etc., which are vital for humans. Pollen is rich in carotenoids - provitamin A, vitamins of group B, vitamins

C, E, 0, P, K and others, phytohormones, antibacterial substances. The rutin present in bee pollen, of which it contains a record amount, carries out the program of prevention of heart diseases - it strengthens the walls of capillaries, improving heart activity. Bee pollen also contains a number of enzymes that play an important role in metabolic processes. Antibactericidal substances of pollen activate the body to fight against viruses and bacteria.

The effect of the described components (components of the proposed dietary supplement) on the human body is known, but their use in a new composition gives a new effect, which allows the use of the proposed dietary supplement as a new therapeutic and preventive agent.

All components of the claimed nutritional supplement are taken in ratios determined experimentally and are optimal for ensuring the specified properties determined by the technical result.

Reducing or increasing the amount of each component below the lower specified limit or above the specified limit leads to a deterioration of the preventive and therapeutic properties of the biologically active additive (narrowing the spectrum of use), and in some cases makes its preventive and/or therapeutic effect impossible (can cause an irritating effect) .

The use of components in the form of oil extracts of plant raw materials in the tool ensures the homogeneity of the mixture and the stable structure of the tool, which does not delaminate during further storage, and the use of natural animal fats in the tool increases the shelf life of dietary supplements (if the storage conditions specified below are observed).

Thanks to the declared new composition, the proposed dietary supplement contains: - fatty acids: Omega-3,

Omega-5, Omega-6, stearic, palmitic, myristic, lauric, oleic acids, linoleic acids; vitamins A, VI, B2, B5, Bb, B12, C, 0, E, PP; sugar, lipids, proteins, trace elements, 60 glucose, sucrose, melacitose, dextrin, amino acids, polyphenols, potassium, copper, magnesium,

calcium, phosphorus, sodium, phenols (carvacrol and thymol), linalyl acetate, geranyl acetate, sulfur, niacin, biotin, manganese, nickel, cobalt, silicon, chlorine, bismuth, arsenic, hormones; folic acid, pantothenic acid, nicotinic acid, inositol.

The claimed dietary supplement, when used, improves the functioning of almost all functional systems of the body. The main effects of its use: stimulates the immune system, increases vitality, increases the body's resistance to infections, accelerates the treatment of infections, supplements the lack of micro- and bioelements; bactericidal (destroys diploid fungus, aspergillus, staphylococcus, campylobacter, klebsiella, Escherichia coli, giardia, pseudomonas and proteus); anti-inflammatory, antiseptic, antiviral; removes and destroys pathogenic microorganisms, eczema, psoriasis, warts, rashes; promotes recovery of the body after physical and mental exhaustion.

The method of preparation of the proposed dietary supplement with complex immunostimulating, antiviral, anti-inflammatory and antibacterial action is as follows. The specified components are taken in the following proportions, mass. 9: mountain honey 43 bee pollen 12 goose fat 10 badger fat 10 bear fat 10 dog fat 10 royal jelly 2 oregano oil 04 Indian hemp oil 2.6.

Goose fat, badger fat, bear fat and dog fat (in equal amounts) are gradually (with slow stirring) heated in a steam bath to a temperature of 4570.

Next, the resulting mixture is gradually cooled to a temperature of 37", mountain honey, royal jelly, bee pollen (powder) and oregano oil are added, mixed and the required amount of hemp oil is added. Then the mixture is effectively mixed for 40 minutes. During the mixing process, the temperature of the mixture is maintained within 37" to 39 "С. A homogeneous plastic mass of an ointment-like consistency of yellowish color is obtained, which is packed in a sterile portion container made of dark glass, and the packed mixture is hermetically sealed.

The advantage of the proposed dietary supplement is that all its components are used in their natural form, because the heat treatment is carried out at a temperature that does not exceed 45 "С.

For preventive purposes, BAD is taken in the amount of 0.25 g twice a day before meals.

Dietary supplements are stored in a place protected from the sun at a temperature of 37-22 "C. The shelf life under the specified conditions is up to 3 years.

Z The proposed dietary supplement is prescribed individually depending on the purpose (for prevention or treatment) and the corresponding diagnosis.

Example 1.

The immunostimulating effect of the proposed dietary supplement was determined during the acute respiratory syndrome epidemic. A group of 10 people was created, who took 0.25 g twice a day of this dietary supplement for 10 days.

During the entire period of the test and according to the results of subsequent studies (during the next three months), none of the mentioned persons fell ill with any colds, in addition, after the first three days of taking dietary supplements, an improvement in sleep was noticed, there was some improvement in the psycho-emotional state, mood improved, performance, memory improvement was noted. Such data make it possible to draw a conclusion about the immunostimulating activity of the proposed composition.

Example 2.

The child is 5.5 years old. The following signs allow us to suspect a chronic infection: frequent abdominal distension, grunting, tongue coated with a light, thick coating, alternating diarrhea and constipation, pale skin against the background of anemia. Giardia and allergic bronchitis were detected. During a year and a half, several courses of medical treatment were conducted, which did not give a positive result. After a course of treatment (the proposed dietary supplement) at a dose of 0.5 g three times a day 30 minutes before meals for three weeks and taking into account nutritional recommendations (a diet containing vegetables and fruits rich in vegetable fiber), an improvement in overall and physical condition of the child, and the results of the coprological examination showed that giardia cysts were not detected.

The use of the proposed biologically active supplement (broad spectrum of action) will improve the results of treatment of patients due to its immunostimulating, antiviral, anti-inflammatory and antibacterial effects.

Claims (1)

USEFUL MODEL FORMULA A biologically active supplement with a complex immunostimulating, antiviral, anti-inflammatory and antibacterial effect, containing bee honey, royal jelly, bee pollen and animal fat, which is distinguished by the fact that it additionally contains oil of oregano and oil of Indian hemp, as animal fat is used goose fat, badger fat, bear fat and dog fat in equal proportions, and mountain honey is used as bee honey in the following proportions, mass. 9o: mountain honey 40-49 bee pollen 10-15 goose fat 9-10 badger fat 9-10 bear fat 9-10 dog fat 9-10 royal jelly 1-3 oregano oil 0.2-0.4 Indian hemp oil rest.