UA100974C2 - Substituted diazepan compounds as orexin receptor antagonists - Google Patents

Substituted diazepan compounds as orexin receptor antagonists

Info

Publication number
UA100974C2
UA100974C2 UAA200906864A UAA200906864A UA100974C2 UA 100974 C2 UA100974 C2 UA 100974C2 UA A200906864 A UAA200906864 A UA A200906864A UA A200906864 A UAA200906864 A UA A200906864A UA 100974 C2 UA100974 C2 UA 100974C2
Authority
UA
Ukraine
Prior art keywords
compounds
receptor antagonists
orexin receptor
substituted diazepan
substituted
Prior art date
Application number
UAA200906864A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Джеффри М. Бергман
Майкл Дж. БРЕСЛИН
Пол Дж. Коулман
Кристофер Д. КОКС
Свати П. Мерсер
Энтони Дж. Рокер
Original Assignee
Мерк Шарп Энд Доме Корп.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Шарп Энд Доме Корп. filed Critical Мерк Шарп Энд Доме Корп.
Priority claimed from PCT/US2007/024690 external-priority patent/WO2008069997A1/en
Publication of UA100974C2 publication Critical patent/UA100974C2/en

Links

Abstract

The present invention is directed to substituted diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
UAA200906864A 2006-12-01 2007-11-30 Substituted diazepan compounds as orexin receptor antagonists UA100974C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87239306P 2006-12-01 2006-12-01
PCT/US2007/024690 WO2008069997A1 (en) 2006-12-01 2007-11-30 Substituted diazepan compounds as orexin receptor antagonists

Publications (1)

Publication Number Publication Date
UA100974C2 true UA100974C2 (en) 2013-02-25

Family

ID=41522310

Family Applications (2)

Application Number Title Priority Date Filing Date
UAA200906864A UA100974C2 (en) 2006-12-01 2007-11-30 Substituted diazepan compounds as orexin receptor antagonists
UAA201015209A UA106873C2 (en) 2006-12-01 2007-11-30 COMPOUNDS OF SUBSTITUTED DIAZEPANES AS ANXAGONES OF OREXIN RECEPTORS

Family Applications After (1)

Application Number Title Priority Date Filing Date
UAA201015209A UA106873C2 (en) 2006-12-01 2007-11-30 COMPOUNDS OF SUBSTITUTED DIAZEPANES AS ANXAGONES OF OREXIN RECEPTORS

Country Status (4)

Country Link
CN (1) CN101627028B (en)
HN (1) HN2009001067A (en)
UA (2) UA100974C2 (en)
ZA (1) ZA200903334B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015536975A (en) * 2012-11-12 2015-12-24 ドクター レディズ ラボラトリーズ リミテッド Polymorphic form of suvorexant
CN103012293A (en) * 2012-12-13 2013-04-03 同济大学 Synthetic method for anti-sleeplessness medicine MK-4305 intermediate
CN103923068B (en) * 2014-02-13 2016-09-07 武汉珈瑜科技有限公司 For compound preparing suvorexant and preparation method thereof
CN105377840B (en) * 2014-05-28 2017-12-22 杭州普晒医药科技有限公司 The salt and its crystal formation and amorphous article of a kind of diazepan compounds
WO2016020405A1 (en) * 2014-08-04 2016-02-11 Sandoz Ag Novel routes of synthesis for the preparation of suvorexant
CN105461699B (en) * 2014-09-25 2019-07-09 广东东阳光药业有限公司 Substituted heterocyclic compound and its application method and purposes
CN104327061A (en) * 2014-10-19 2015-02-04 湖南华腾制药有限公司 Preparation method of bromobenzo[d]oxazole derivative
CN104649983B (en) * 2014-12-23 2018-01-23 广东东阳光药业有限公司 A kind of sour preparation method
CN106349228B (en) * 2015-07-17 2019-07-09 广东东阳光药业有限公司 Substituted quianzolinones and its preparation method and application
US10370380B2 (en) * 2015-11-23 2019-08-06 Sunshine Lake Pharma Co., Ltd. Octahydropyrrolo[3,4-c]pyrrole derivatives and uses thereof
CN106916149A (en) * 2015-12-25 2017-07-04 上海奥博生物医药技术有限公司 A kind of method for preparing Su Woleisheng
CN107021964A (en) * 2016-02-01 2017-08-08 广东东阳光药业有限公司 7-naphthyridine derivatives and application thereof
CN105949203B (en) * 2016-05-24 2018-07-13 广东东阳光药业有限公司 Octahydro pyrrolo- [3,4-c] azole derivatives and its application method and purposes
CN106866632A (en) * 2017-01-19 2017-06-20 成都美域高制药有限公司 A kind of method for preparing Suvorexant intermediates and the like
CN109942563A (en) * 2017-12-21 2019-06-28 上海医药工业研究院 A kind of preparation method of Su Woleisheng midbody compound
CN111943945B (en) * 2020-09-03 2022-07-12 上海应用技术大学 Suvorexant intermediate and preparation method thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS536156B2 (en) * 1972-10-30 1978-03-04
AU3578595A (en) * 1994-11-25 1996-06-19 Nippon Chemiphar Co. Ltd. Quinazoline derivative
MXPA06002672A (en) * 2003-09-09 2006-06-06 Hoffmann La Roche 1-benzoyl-piperazine derivatives as glycine uptake inhibitors for the treatment of psychoses.

Also Published As

Publication number Publication date
UA106873C2 (en) 2014-10-27
ZA200903334B (en) 2010-04-28
HN2009001067A (en) 2011-05-11
CN101627028A (en) 2010-01-13
CN101627028B (en) 2013-03-27

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