TWM631506U - Dispensing device for molecular testing - Google Patents

Abstract

The present invention is a dispensing device for molecular testing, which enables a pipette to inject a plurality of samples in a sample tray into a plurality of detection grooves on a detection tray, and inject a plurality of drugs into an adapter tray. After a drug tank is prepared, the mixed drug in the drug tank is then injected into each detection tank on the detection disk with a pipette. The dispensing device includes a disk body positioning mechanism, an adapter disk supply mechanism, a drug injection mechanism, a detection disk transfer mechanism, a liquid pipetting mechanism and a sample disk input mechanism. The detection disk transfer mechanism automatically positions the detection disk, the disk positioning mechanism cooperates with the drug injection mechanism to mix the drug, and cooperates with the pipetting mechanism to dispense the mixed drug and the sample to the test disk, thereby achieving automation to reduce manpower and improve test quality. .

Description

Dispensing device for molecular testing

This creation system relates to an automated equipment in a biochemical laboratory, especially a dispensing device that dispenses micro-drugs and samples to different positions on a micro-porous plate.

At present, in molecular testing operations, such as ribonucleic acid detection of the new coronavirus, multiple nucleic acid extraction samples are first injected into multiple detection grooves on a micro-porous plate, and then the reagents required for the detection are injected. Respectively inject into the detection tanks filled with specimens, and then manually seal the porous disk (that is, cover the porous disk with a thin film to isolate the contents of the detection tank from the outside world), and finally seal the porous disk after sealing. Manually placed in a real-time quantitative polymerase chain reaction (Real-time Quantitative Polymerase. Chain Reaction, referred to as Q-PCR) detector for detection.

However, there are dozens of detection grooves in a multi-well plate for inspection, and there are more than one type of drugs that need to be prepared and injected. It is very time-consuming and labor-intensive for the simple and repetitive sample and drug dispensing operations.

Therefore, there is a real need for improvement in the sample and drug dispensing operations for molecular testing in the prior art.

In view of the above-mentioned shortcomings and deficiencies of the prior art, the present invention provides a dispensing device for molecular testing to automate the dispensing of samples and drugs for molecular testing to greatly reduce manpower and improve work quality.

In order to achieve the above-mentioned creative purpose, the present invention further provides a dispensing device for molecular testing, which is used to move a sample tray, a detection tray and an adapter tray, the sample tray contains a plurality of samples, the detection The disc includes a plurality of detection slots, the adapter plate includes a drug slot; the dispensing device for molecular testing includes: a base; A disc body positioning mechanism, which is arranged on the base and has a disc body slide seat; the disc body slide base can be moved to a medicine injection position or a liquid supply position; the disc body slide seat is used to ride the rotary the receiving tray or the specimen tray; an adapter plate supply mechanism, which is arranged on the base; the adapter plate supply mechanism is used for accommodating the adapter plate, and can move the accommodated adapter plate to the plate body of the plate body positioning mechanism On the slide: a medicine injection mechanism, which is set on the base and has a plurality of medicine injection heads, and the medicine injection heads are respectively connected with a plurality of medicines; each of the medicine injection heads can be moved to the top of the medicine injection position of the disk body positioning mechanism; the The medicine injection head is used for injecting the medicines into the medicine groove of the adapter plate moved by the disc body slide to the medicine injection position respectively, so as to form a mixed medicine; a test disk transfer mechanism, which is arranged on the base; the test disk transfer mechanism is used for carrying the test disk and can move the test disk to a dispensing position; a sample tray input mechanism, which is used for moving the sample tray to the tray body sliding seat of the tray body positioning mechanism; A pipetting mechanism, which is arranged on the base, and includes: a pipette, which can be moved above the liquid supply position and suck the mixed medicine in the medicine tank of the adapter plate located at the liquid supply position; the pipette can be moved to the dispensing position Above and inject the sucked mixed medicament into the detection grooves of the detection tray located at the dispensing position; the pipette can move above the liquid supply position and suck into the sample tray located at the liquid supply position the specimens; the pipette can move above the dispensing position and inject the sucked specimens into the detection groove tray positioning mechanism of the detection tray located at the dispensing position.

The advantage of the present invention is that the disk body positioning mechanism, the adapter disk supply mechanism and the drug injection mechanism cooperate with each other to automatically mix (ie, dispense) the medicament and place the mixed medicament in the adapter disk for use; then the disk body positioning mechanism, The detection plate transfer mechanism and the liquid pipetting mechanism cooperate with each other to automatically dispense the mixed medicine in the transfer plate into the detection tank of the detection plate; finally, the plate positioning mechanism, the liquid transfer mechanism and the sample plate input mechanism cooperate with each other. The sample in the sample tray is automatically dispensed to the test tray. In this way, the present invention automates the sample and drug dispensing operations for molecular testing to greatly reduce manpower and improve work quality.

Further, in the dispensing device for molecular testing, the detection plate transfer mechanism has a main line conveying structure, which is arranged on the base and has two main line conveying belts; the two main line conveying belts are spaced apart from each other are arranged, and are respectively used to abut the opposite sides of the detection plate, and are used to transport the detection plate to an output end of the main line conveying structure along a main line direction; the branch line conveying structure is arranged on the base, And has at least one main bridge conveyor belt and at least one branch conveyor belt sequentially arranged along the branch line direction, the branch line direction is non-parallel with the main line direction, and the dispensing position is located at one end of the branch line conveyor belt toward the branch line direction, wherein The at least one main bridging conveyor belt can be raised and lowered between the two main line conveyor belts of the main line conveying structure, and can be raised to lift up the detection plate located on the two main line conveyor belts, and can be moved along the branch line direction. The jacked-up inspection plate is transported to the branch conveyor belt; the at least one branch conveyor belt is used to receive the inspection plate from the at least one main bridge conveyor belt and transport the inspection plate to the dispensing position along the branch line direction; Wherein, the at least one branch conveyor belt and the at least one main bridging conveyor belt can move the detection plate located at the dispensing position to the main line conveying structure opposite to the branch line direction.

Further, in the described dispensing device for molecular testing, the position of the at least one branch conveyor belt of the branch line conveying structure is higher than the position of the two main line conveyor belts of the main line conveying structure; The at least one main bridging conveyor belt can be moved upward to a height corresponding to the branch conveyor belt.

Further, the dispensing device for molecular testing, wherein the branch conveyor structure has at least one pair of bridge conveyor belts, which are arranged on one side of the two main line conveyor belts and located on the at least one main bridge conveyor belt between the at least one branch conveyor belt, and used for conveying the detection disc from the at least one main bridge conveyor belt to the at least one branch conveyor belt; the at least one auxiliary bridge conveyor belt and the at least one main bridge conveyor belt The belts are raised and lowered together, so that the height of the at least one pair of bridging conveyor belts selectively corresponds to the at least one branch conveyor belt.

Further, the dispensing device for molecular testing, wherein the dispensing device for molecular testing has a test disk supply mechanism, which is provided on the base, and has a disk storage rack, which is used for For placing the detection tray; a tray-loading linear module, which has a tray-loading slide, and the tray-loading slide can be moved to the bottom of the storage tray or below the two main line conveyor belts of the detection tray transfer mechanism; A tray lift module, which is arranged on the tray tray carriage of the tray tray linear module, and has a tray tray tray; the tray tray tray can move to the bottom of the tray rack along with the tray tray tray, and It can move upward to lift the test disk on the disk storage rack; the disk lift seat can be moved to between the two main line conveyor belts of the test disk transfer mechanism along with the disk transfer carriage, and can be downward moving to move the lifted test disk to the two main line conveyor belts of the test disk transfer mechanism.

Further, the dispensing device for molecular testing, wherein the adapter plate supply mechanism has a stacking rack for placing the adapter plate, the bottom of the stacking rack is formed with a plate drop opening, the stacking The rack selectively allows the adapter plate on the stacking rack to pass downward through the tray opening; a tray feeding module is arranged below the stacking rack and used to move the adapter plate through the tray opening to the disk body sliding seat of the disk body positioning mechanism; the disk feeding module has: a disk feeding seat, which is used to receive the adapter plate passing through the disk drop opening, and the disk feeding seat can move to the stacking rack The bottom of the disk body positioning mechanism and above the disk body sliding seat of the disk body positioning mechanism; the top surface of the disk body sliding seat of the disk body positioning mechanism is concavely provided with a receiving groove; the disk body positioning mechanism has a lifting plate, which is located in Inside the accommodating groove of the disk body sliding seat, and can protrude upwards from the accommodating groove to push up the adapter plate on the disk feeding seat above the disk body sliding seat.

Further, the described dispensing device for molecular testing further has a casing, which is arranged on the base and forms a refrigerated space, the disk positioning mechanism, the adapter disk supply mechanism, the drug injection The mechanism, the test tray transfer mechanism, the liquid pipetting mechanism and the sample tray input mechanism are located in the refrigerated space; a sample tray input port and a test tray output port are formed on the shell; an air conditioner is installed in the the temperature of the refrigerated space is controlled; the sample tray input mechanism has an input gripper, and the input gripper can protrude from the sample tray input port of the housing from the housing to insert the sample tray outside the housing. The specimen disc is clamped into the casing; the detection disc transfer mechanism has an output clamping claw, and the output clamping claw can protrude from the outer casing from the detection disc output port of the casing to move the detection disc transfer mechanism. The detection disc is clamped to the outside of the casing.

The technical means adopted by the present creation to achieve the predetermined creation purpose are further described below in conjunction with the drawings and preferred embodiments of the present creation.

Please refer to FIGS. 1 to 4 , 7 , and 18 to 20 , the dispensing device for molecular testing of the present invention is used to move a sample tray 92 , a detection tray 93 and an adapter tray 94 . Specifically, the dispensing device first injects a plurality of medicines into a medicine tank 941 on the adapter plate 94 (as shown in FIG. 7 ), and then uses a pipette 62 to inject the mixed medicine in the medicine tank 941 into the detection plate 93, and a pipette 62 is used to inject a plurality of samples in the sample tray 92 into the plurality of detection grooves on the detection tray 93 that have been filled with the mixed drug.

The dispensing device for molecular testing of the present invention includes: a base 10, a plate positioning mechanism 20, an adapter plate supply mechanism 30, a drug injection mechanism 40, a detection plate transfer mechanism 55, and a liquid pipetting mechanism 60, and a sample disk input mechanism 70; and in this embodiment, it further has a test disk supply mechanism 50, a housing 81 and an air conditioner 82 (as shown in FIG. 1).

The aforementioned casing 81 is disposed on the base 10 and forms a refrigerated space. Specifically, the refrigerated space is the inner space formed by the casing 81. The aforementioned air conditioner 82 is installed in the refrigerated space and controls the temperature of the refrigerated space. The rest of the dispensing device Each mechanism is installed in the refrigerated space formed by the housing 81 to ensure the quality of the medicine and the activity of the specimen. The housing 81 is formed with a sample tray inlet 811 and a detection tray inlet 812 and a detection tray outlet 813 (as shown in FIG. 20 ) which are oppositely disposed.

Please refer to FIG. 5 to FIG. 9 , the aforementioned disk body positioning mechanism 20 is disposed on the base 10 , and the disk body positioning mechanism 20 has a linear module 21 , and preferably has an air cylinder 22 and a disk lift plate 23 . The linear module 21 is provided with a disc body slide 211 , and the disc body slide base 211 can be controlled to move along a disc body transfer direction D1 to a medicine injection position P1 or a liquid supply position P2 .

An adapter plate 94 or a sample plate 92 (as shown in FIG. 18 and FIG. 19 ) can be mounted on the disk body slide 211 , and the mounted adapter plate 94 can be placed at the injection position P1 and supplied with liquid It moves back and forth between the positions P2, and the mounted adapter tray 94 or the specimen tray 92 can be moved to the liquid supply position P2. A receiving groove 212 is preferably recessed on the top surface of the disk body sliding seat 211 (as shown in FIG. 6 ).

The air cylinder 22 is arranged on the disc body sliding seat 211, and the disc lift plate 23 is connected to the air cylinder 22 and is arranged in the accommodating groove 212 of the disc body sliding seat 211. It shrinks downward in the container groove 212 .

The aforementioned adapter plate supply mechanism 30 is provided on the base 10 . The adapter plate supply mechanism 30 can accommodate the adapter plate 94 and can move the accommodated adapter plate 94 to the plate body slide of the plate body positioning mechanism 20 . 211 on. In this embodiment, the adapter tray supply mechanism 30 has a stacking rack 31 and a tray feeding module 32 . The stacking rack 31 can accommodate the adapter trays 94 , and specifically, a plurality of unused adapter trays 94 can be vertically stacked on the stacking rack 31 . A tray opening 311 is formed at the bottom of the stacking rack 31 , and a tray locking cylinder 312 is installed at the periphery of the tray opening 311 . The moving end of the locking plate cylinder 312 can be controlled to protrude and move toward the center of the plate drop opening 311, so that the adapter plate 94 on the stacking rack 31 cannot pass through the plate drop opening 311; the moving end of the locking plate cylinder 312 can also be retracted. And exit the tray opening 311 , thereby allowing the adapter tray 94 on the stacking rack 31 to pass downward through the tray opening 311 .

The tray feeding module 32 is disposed below the stacking rack 31 , and can receive the adapter tray 94 dropped through the tray drop opening 311 and move the adapter tray 94 to the tray body sliding seat 211 of the above-mentioned tray body positioning mechanism 20 . Specifically, the tray feeding module 32 has a tray feeding base 321 and a tray feeding linear module 322. The tray feeding base 321 receives the adapter tray 94 passing through the tray drop opening 311, and the tray feeding linear module 322 can be controlled and driven The tray feeder 321 moves perpendicular to the tray transfer direction D1, so that the tray feeder 321 and the adapter tray 94 it carries are moved from the bottom of the stacking rack 31 to the top of the tray 211 of the tray positioning mechanism 20 ( as shown in Figure 7).

Please refer to FIG. 7 and FIG. 8 , when the disk feeding seat 321 is located above the disk body sliding seat 211 , the air cylinder 22 of the disk body positioning mechanism 20 will drive the disk lifting plate 23 to protrude upward from the accommodating groove 212 , thereby making the lifting plate 23 protrude upwards. The disk plate 23 lifts up the adapter plate 94 on the disk feed base 321 located above it, and then the disk feed linear module 322 moves the disk feed base 321 back to the bottom of the stacker 31; then, the air cylinder 22 makes the disk lift plate 23 down Move and retract into the container groove 212, and then move the adapter plate 94 to the disk body sliding seat 211. At this time, the disk body sliding seat 211 can move the mounted adapter plate 94 to the injection position P1 to The medicine feeding mechanism 40 performs the next operation.

Please refer to FIG. 3 , FIG. 4 , FIG. 7 and FIG. 9 , the aforementioned drug injection mechanism 40 is disposed on the base 10 and has a plurality of drug injection heads 41 , each drug injection head 41 is connected to one of the drugs, and each drug injection The head 41 can move to above the injection position P1 of the disc body positioning mechanism 20, and can inject the connected medicine into the medicine slot 941 of the adapter plate 94 moved by the disc body slide 211 to the medicine injection position P1, thereby forming The aforementioned mixed medicines. In the present embodiment, the drug injection mechanism 40 has a turret 42 , and the drug injection heads 41 are arranged on the turret 42 at a circumferential interval, and move in sequence to the top of the drug injection position P1 with the rotation of the turret 42 .

Please refer to FIG. 1 , FIG. 2 , and FIG. 10 to FIG. 12 , the aforementioned detection disk supply mechanism 50 is arranged on the base 10 and has a disk storage rack 51 , a disk-carrying linear module 52 and a disk-lifting module 53. The disk rack 51 is used for placing the detection disk 93 , and specifically, the disk rack 51 has a plurality of platforms 511 and a rack 512 . The platforms 511 are arranged at intervals up and down, and each platform 511 can carry an unused detection plate 93 . The rack 512 is disposed on one side of the storage rack 51 and extends up and down, whereby the rack 512 can be driven by a gear 54 to move the storage rack 51 up and down as a whole. The position of the disk rack 51 corresponds to the detection disk inlet 812 of the housing 81 , whereby a plurality of unused detection disks 93 can be placed on the disk rack 51 through the detection disk inlet 812 . The disk module 53 moves the detection disks 93 on the disk storage rack 51 to the detection disk transfer mechanism 55 one by one.

The tray-carrying linear module 52 has a tray-carrying slide 521 , and the tray-carrying slide 521 can be controlled to move back and forth between the bottom of the tray storage rack 51 and the detection tray transfer mechanism 55 . The tray lift module 53 is disposed on the tray tray carriage 521 of the tray tray linear module 52 , and has a plurality of cylinders 531 and a tray tray 532 . A plurality of air cylinders 531 are arranged in series on the tray-carrying slide 521 from bottom to top, and the tray-lifting base 532 is set at the moving end of the uppermost cylinder 531 , so that the tray-lifting base 532 can be moved upward or downward by controlling the expansion and contraction of the cylinder 531 . Move Downward.

Please refer to FIG. 3 , FIG. 10 , and FIGS. 13 to 15 . The aforementioned detection disk transfer mechanism 55 is disposed on the base 10 , and is arranged at a distance from the disk storage rack 51 of the detection disk supply mechanism 50 . The test disk transfer mechanism 55 is used to carry the test disk 93 from the test disk supply mechanism 50, and can move the test disk 93 to a dispensing position P3. In this embodiment, the detection disk transfer mechanism 55 has a main line conveying structure 56 , a branch line conveying structure 57 and an output gripper 58 . The general operation sequence of the test disk transfer mechanism 55 is as follows: first move the unused test disk 93 from the test disk supply mechanism 50 to the end of the main line conveying structure 56 facing the test disk inlet 812 of the housing 81, and then move the unused test disk 93 The detection disc 93 is transferred to the branch line conveying structure 57 and conveyed to the dispensing position P3, where the specimen and the drug are injected. After the injection is completed, the branch line conveying structure 57 reversely returns the detection disc 93 to the main line conveying structure 56, and finally is conveyed by the main line The structure 56 transports the processed test disk 93 to the test disk outlet 813 for continued operation by other mechanisms, and the specific process will be described in detail later.

The main line conveying structure 56 is arranged on the base 10 and has two main line conveying belts 561 . The two main line conveyor belts 561 are spaced apart from each other, and are used to support opposite sides of the detection disk 93 respectively, and are used to transport the detection disk 93 from the detection disk supply mechanism 50 to an output of the main line conveyor structure 56 along a main line direction Dm end 562.

The specific process of moving the test disk 93 from the test disk supply mechanism 50 to the test disk transfer mechanism 55 is as follows: the disk transfer carriage 521 of the test disk supply mechanism 50 moves the disk lift seat 532 to the bottom of the disk storage rack 51, and then the air cylinder 531 The disk lifter 532 is driven to move upward, thereby lifting the detection disk 93 on the lowermost disk stocker 51 . Next, the tray lifter 521 moves the tray lifter 532 between the two main line conveyor belts 561 of the detection tray transfer mechanism 55 , and then the cylinder 531 drives the tray lifter 532 to move downward, thereby making the previously lifted tray 532 move downward. The lifted test disk 93 is moved to the second main line conveyor belt 561 of the test disk transfer mechanism 55 , so far the test disk 93 has been moved from the test disk supply mechanism 50 to the test disk transfer mechanism 55 .

The branch line conveying structure 57 is arranged on the base 10, and has at least one main bridging conveyor belt 571, at least one auxiliary bridging conveyor belt 572 and at least one branch line conveyor belt 573 arranged in sequence along the branch line direction Db, wherein the branch line direction Db and the main line The directions Dm are non-parallel. The aforementioned dispensing position P3 is located at one end of the branch conveyor belt 573 in the branch line direction Db.

Specifically, the number of the at least one main bridge conveyor belt 571 is two, which are arranged in parallel and spaced apart from each other and are respectively used to support opposite sides of the detection plate 93 . The two main bridging conveyor belts 571 can be raised and lowered between the two main line conveyor belts 561 of the main line conveying structure 56 , and can be raised to lift the detection plate 93 located on the second main line conveyor belt 561 (as shown in FIGS. 14 to 15 ) , and the lifted detection disc 93 can be conveyed to the branch conveyor belt 573 along the branch line direction Db. Specifically, the branch line conveying structure 57 has two lifting walls 574 , and the two main bridging conveyor belts 571 are respectively disposed on one side of the two lifting walls 574 facing each other.

The number of the main bridging conveyor belts 571 is not limited to this. In other preferred embodiments, only a single main bridging conveyor belt 571 can be provided, which supports the center of the detection plate 93, so that it can also be conveyed with two main bridging conveyor belts. The belt 571 achieves the same conveying effect, and the number of the auxiliary bridge conveyor belt 572 and the branch conveyor belt 573 can also have the same change as the main bridge conveyor belt 571 .

Specifically, the number of the auxiliary bridging conveyor belts 572 is two, and the two auxiliary bridging conveyor belts 572 are respectively disposed on one side of the two lifting walls 574 facing each other. Each auxiliary bridge conveyor belt 572 is arranged on one side of one of the main line conveyor belts 561 (that is, not located between the two main line conveyor belts 561), and is located between the two main bridge conveyor belts 571 and the two branch line conveyor belts 573, and can be The detection disk 93 from the main bridge conveyor belt 571 is conveyed to the branch conveyor belt 573 . The auxiliary bridging conveyor belt 572 and the main bridging conveyor belt 571 are raised and lowered together, so that the auxiliary bridging conveyor belt 572 can correspond to the branch conveyor belt 573 in height. The heights are the same, so that the detection disc 93 can smoothly move from the auxiliary bridge conveyor belt 572 to the branch line conveyor belt 573 .

Regarding the common lifting of the auxiliary bridge conveyor belt 572 and the main bridge conveyor belt 571, specifically, the branch line conveying structure 57 has a lift driver 575, which connects the two lift walls 574 and drives the two lift side walls 35 to lift together, thereby enabling the auxiliary bridge conveyor belt to rise and fall together. 572 ascends and descends together with the main bridge conveyor belt 571 .

In this embodiment, a limit plate 576 is provided at intervals above each auxiliary bridge conveyor belt 572, and each limit plate 576 partially shields the corresponding auxiliary bridge conveyor belt 572. Therefore, when viewed from above, the auxiliary bridge conveyor belt Only a small part of the width of the inside of the 572 is exposed. The two limiting plates 576 above the second bridging conveyor belts 572 can limit the moving direction of the detection plate 93 so that the detection plate 93 can only move along the branch line direction Db. A limiting plate is also arranged above the aforementioned main line conveyor belt 561 .

In addition, in this embodiment, the main bridging conveyor belt 571 and the auxiliary bridging conveyor belt 572 located on the same lifting wall 574 are connected together in a circle, so that one motor can drive the main bridging conveyor belt 571 and the auxiliary bridging conveyor belt 572 at the same time; in other In a preferred embodiment, the main bridging conveyor belt 571 and the auxiliary bridging conveyor belt 572 located on the same lifting wall 574 may not be connected, and each form a circle.

The effect of arranging the auxiliary bridge conveyor belt 572 is to allow the position of the branch line conveyor belt 573 to be lower than the main line conveyor belt 561, but not limited to this. One end of the main bridge conveyor belt 571 in the branch line direction Db directly receives the detection disk 93 from the main bridge conveyor belt 571 . In addition, the position of the branch conveyor belt 573 is higher than the second main line conveyor belt 561 of the main line conveyor structure 56 , and the main bridge conveyor belt 571 can be moved upward to a height corresponding to the branch conveyor belt 573 to convey the detection disk 93 .

Please refer to FIG. 16 , the aforementioned pipetting mechanism 60 is disposed on the base 10 and includes a pipetting positioning mechanism and the aforementioned pipette 62 . The pipetting positioning mechanism has a plurality of connected pipetting linear modules 61, and the pipette 62 is arranged on a slider of one of the pipetting linear modules 61; The group 61 can respectively control the position of the pipette 62 in different directions, and then can move the pipette 62 to the top of the liquid supply position P2 and absorb the mixed medicine in the medicine tank 941 of the adapter plate 94 located at the liquid supply position P2; Next, the pipette 62 can move above the dispensing position P3 and inject the sucked mixed medicine into each detection groove of the detection plate 93 located at the dispensing position P3.

In addition, the pipetting positioning mechanism can also move the pipette 62 above the liquid supply position P2 and suck the specimen in the sample tray 92 located at the liquid supply position P2; then, the pipette 62 can move to the dispensing position P3 Then, the sucked specimen is injected into each detection groove of the detection disk 93 located at the dispensing position P3.

After the mixed medicine is dispensed to the detection tray 93 , the sample tray input mechanism 70 , the tray body positioning mechanism 20 and the pipetting mechanism 60 cooperate with each other to dispense the specimen from the specimen tray 92 to the detection tray 93 .

Please refer to FIG. 17 to FIG. 19 , the aforementioned sample disk input mechanism 70 is used to move the sample disk 92 to be processed onto the disk body slide 211 of the disk body positioning mechanism 20 ; in this embodiment, The sample tray 92 is to perform nucleic acid extraction in a nucleic acid extraction device other than this creation. After the extraction is completed, the sample tray input mechanism 70 of this creation moves the sample tray 92 from the nucleic acid extraction device to this creation for sample separation. Note homework. Specifically, the specimen disk input mechanism 70 has a first input linear module 71 , a second input linear module 72 and an input gripper 73 , and the second input linear module 72 is disposed in the first input linear module In order to increase the moving stroke, the input gripper 73 is arranged on the slide of the second input linear module 72; thereby, the input gripper 73 can protrude from the sample tray inlet 811 of the housing 81 to The specimen disk 92 located outside the casing is clamped into the casing 81 .

Next, the input gripper 73 places the specimen disc 92 on the disc body slide 211 of the disc body positioning mechanism 20 , and then the disc body slide 211 moves the loaded specimen disc 92 to the liquid supply position P2 and is moved by the moving disc slide 211 . The liquid mechanism 60 controls the pipette 62 to inject the plurality of samples in the sample tray 92 located at the liquid supply position P2 into each of the detection tanks in the detection tray 93 located at the dispensing position P3 into which the mixed drug has been injected. So far, the sample and drug dispensing operation of the test disk 93 has been completed. Next, the test disk transfer mechanism 55 moves the processed test disk 93 to a non-present Q-PCR detector to analyze the test disk 93 .

Please refer to FIG. 10 , FIG. 14 , FIG. 19 and FIG. 20 . Specifically, after the sample and drug dispensing operation of the detection plate 93 is completed, the branch conveyor belt 573 and the main bridge conveyor belt 571 will be opposite to the branch line direction. Db operates to move the test disc 93 located at the dispensing position P3 to the main line conveying structure 56, and then the main line conveying belt 561 of the main line conveying structure 56 continues to transport the test disc 93 to the test disc outlet 813 along the main line direction Dm (see FIG. 20 ). output 562 shown). The output gripper 58 grips the detection disc 93 at the output end 562 and protrudes from the detection disc outlet 813 of the housing 81 to the outer housing 81 to clamp the detection disc 93 to the outside of the housing 81 and hand over to the Q-PCR that is not of the present creation Detector.

The advantage of the detection disc transfer mechanism 55 is that, if the general automation equipment needs to move the detection disc 93 from one conveyor belt to another non-parallel conveyor belt, it is usually necessary to set up a multi-driver between the two conveyor belts. A multi-axis mechanism, such as a robotic arm, can do the trick. In the present invention, by setting the main bridge conveyor belt 571 that can be lifted and lowered, only one lift driver can be provided to achieve the same transfer effect as multiple drivers, which can save costs.

During the operation of the present creation, the unused adapter plate 94 is transferred by the adapter plate supply mechanism 30 to the plate body positioning mechanism 20, and then the adapter plate 94 is moved by the plate body positioning mechanism 20 to the injection position P1 for injection. The mechanism 40 injects a variety of medicines to form mixed medicines in the adapter plate 94 , and then the adapter plate 94 is moved to the liquid supply position P2 by the plate body positioning mechanism 20 to wait for the pipetting mechanism 60 .

At the same time as the transfer tray 94 is processed, the unused test tray 93 is transferred by the test tray supply mechanism to the main line conveyor belt 561 of the test tray transfer mechanism 55, and then by the main bridge conveyor belt 571, the sub bridge conveyor belt 572 and the The branch conveyor belt 573 is continuously conveyed to the dispensing position P3. At this time, the adapter plate 94 and the detection plate 93 are positioned at the liquid supply position P2 and the dispensing position P3, respectively.

Next, use the sample disk input mechanism 70 to grab the sample disk 92 with the nucleic acid extraction process completed from another device other than the present invention onto the disk body positioning mechanism 20 of the present invention, and use the disk body positioning mechanism 20 to place the sample. The tray 92 is moved to the liquid supply position P2, and then the liquid pipetting mechanism 60 injects the plurality of samples in the sample tray 92 into the detection tanks of the detection tray 93 into which the mixed drug has been injected. Completion, finally, the test disk 93 is moved from the dispensing position P3 to the output gripper 58 by the test disk transfer mechanism 55 , and the output gripper 58 is used to transfer the test disk 93 to another device other than the present invention.

In this embodiment, the mixed medicine in the adapter plate 94 is injected into the detection plate 93 first, and then the specimen in the specimen plate 92 is injected into the detection plate 93, but it is not limited, and the specimen in the specimen plate 92 can also be injected first. The test tray 93 is injected, and then the adapter tray 94 is processed.

To sum up, the disk body positioning mechanism 20, the adapter disk supply mechanism 30 and the drug injection mechanism 40 of the present invention cooperate with each other to automatically mix (ie, dispense) the medicament and place the mixed medicament in the adapter disk 94 for use; Then, the disk positioning mechanism 20, the detection disk transfer mechanism 55 and the liquid transfer mechanism 60 cooperate with each other to automatically dispense the mixed medicine in the adapter disk 94 into the detection groove of the detection disk 93; finally, the disk positioning mechanism 20, The pipetting mechanism 60 and the specimen tray input mechanism 70 cooperate with each other to automatically dispense the specimen in the specimen tray 92 to the detection tray 93 . In this way, the present invention automates the sample and drug dispensing operations for molecular testing to greatly reduce manpower and improve work quality.

The above is only the preferred embodiment of the creation, and does not limit the creation in any form. Although the creation has been disclosed as above in the preferred embodiment, it is not intended to limit the creation. Those of ordinary knowledge, within the scope of the technical solution of this creation, can make some changes or modifications to equivalent embodiments of equivalent changes by using the technical content disclosed above. The technical essence of the creation Any simple modifications, equivalent changes and modifications made to the above embodiments still fall within the scope of the technical solution of the creation.

10: Base 20: Disc positioning mechanism 21: Linear Module 211: Disc body slider 212: Container 22: Cylinder 23: Lifting plate 30: Adapter plate supply mechanism 31: Stacking Rack 311: Disk opening 312: Lock disc cylinder 32: Disk feeding module 321: Disk feeder 322: Feeding linear module 40: Injection institutions 41: Injection head 42: Turret 50: Test plate supply mechanism 51: storage rack 511: Platform 512: rack 52: Moving plate linear module 521: Carriage Slider 53: Disk lift module 531: Cylinder 532: Lifting plate seat 54: Gear 55: Detection of disk transfer mechanism 56: Main line conveying structure 561: Main Line Conveyor Belt 562: output terminal 57: Branch conveyor structure 571: Main Bridge Conveyor Belt 572: Secondary Bridge Conveyor Belt 573: Branch conveyor belt 574: Lift Wall 575: Lift Drive 576: Limit Plate 58: Output gripper 60: Pipetting mechanism 61: Pipetting Linear Module 62: Pipette 70: Specimen tray input mechanism 71: The first input linear module 72: Second input linear module 73: Input gripper 81: Shell 811: Specimen tray entrance 812: Detect disk entry 813: Test disk exit 82: Air conditioner 91: Pipette 92: Specimen tray 93: Test disk 94: Adapter plate 941: Potion Slot D1: Plate transfer direction Db: branch line direction Dm: main line direction P1: Injection position P2: Liquid supply position P3: Dispense Position

Figure 1 is a three-dimensional appearance view of this creation. Fig. 2 is a three-dimensional appearance view of the present creation after the casing is omitted. Figure 3 is a schematic top view of this creation. Figure 4 is an exploded view of the three-dimensional components of this creation. FIG. 5 is a three-dimensional external view of the adapter plate supply mechanism of the present invention. FIG. 6 is a three-dimensional external view of the adapter plate supply mechanism of the present invention from another angle. FIG. 7 and FIG. 8 are three-dimensional action diagrams of the adapter plate supply mechanism of the present invention. FIG. 9 is a schematic side view of the disk body positioning mechanism of the present invention. FIG. 10 is a perspective view of the related structure of the present invention for inputting and transferring the detection disk. 11 and 12 are partial cross-sectional action views of the present invention, showing the movement of the test disk from the test disk supply mechanism to the test disk transfer mechanism. Fig. 13 is a three-dimensional external view of the branch line conveying structure of the present invention. FIG. 14 and FIG. 15 are schematic cross-sectional action diagrams of the branch line conveying structure of the present invention. FIG. 16 is a schematic diagram of the front view of the pipetting mechanism of the present invention. FIG. 17 is a perspective external view of the sample tray input mechanism of the present invention. FIG. 18 and FIG. 19 are schematic side views of the operation of the sample tray input mechanism of the present invention. FIG. 20 is a schematic side view of the output gripper of the present invention.

10: Base

30: Adapter plate supply mechanism

40: Injection institutions

41: Injection head

42: Turret

50: Test plate supply mechanism

55: Detection of disk transfer mechanism

60: Pipetting mechanism

70: Specimen tray input mechanism

93: Test disk

94: Adapter plate

Claims (7)

A dispensing device for molecular testing, which is used to move a sample plate, a detection plate and an adapter plate, the sample plate contains a plurality of samples, the detection plate includes a plurality of detection grooves, and the adapter plate contains A medicament tank; the dispensing device for molecular testing includes: a base; A disc body positioning mechanism, which is arranged on the base and has a disc body slide seat; the disc body slide base can be moved to a medicine injection position or a liquid supply position; the disc body slide seat is used to ride the rotary the receiving tray or the specimen tray; an adapter plate supply mechanism, which is arranged on the base; the adapter plate supply mechanism is used for accommodating the adapter plate, and can move the accommodated adapter plate to the plate body of the plate body positioning mechanism On the slide: a medicine injection mechanism, which is set on the base and has a plurality of medicine injection heads, and the medicine injection heads are respectively connected with a plurality of medicines; each of the medicine injection heads can be moved to the top of the medicine injection position of the disk body positioning mechanism; the The medicine injection head is used for injecting the medicines into the medicine groove of the adapter plate moved by the disc body slide to the medicine injection position respectively, so as to form a mixed medicine; a test disk transfer mechanism, which is arranged on the base; the test disk transfer mechanism is used for carrying the test disk and can move the test disk to a dispensing position; a sample tray input mechanism, which is used for moving the sample tray to the tray body sliding seat of the tray body positioning mechanism; A pipetting mechanism, which is arranged on the base, and includes: a pipette, which can be moved above the liquid supply position and suck the mixed medicine in the medicine tank of the adapter plate located at the liquid supply position; the pipette can be moved to the dispensing position Above and inject the sucked mixed medicament into the detection grooves of the detection tray located at the dispensing position; the pipette can move above the liquid supply position and suck into the sample tray located at the liquid supply position the specimens; the pipette can move above the dispensing position and inject the sucked specimens into the detection groove tray positioning mechanism of the detection tray located at the dispensing position. The dispensing device for molecular testing according to claim 1, wherein the test disc transfer mechanism has A main line conveying structure is arranged on the base and has Two main line conveyor belts; the two main line conveyor belts are spaced apart from each other, and are respectively used to abut the opposite sides of the detection plate, and are used to convey the detection plate along a main line direction to an output end of the main line conveying structure; A branch line conveying structure, which is arranged on the base, and has at least one main bridging conveyor belt and at least one branch conveyor belt sequentially arranged along the branch line direction, the branch line direction is non-parallel with the main line direction, and the dispensing position is located at One end of the branch conveyor belt in the direction of the branch line, wherein The at least one main bridging conveyor belt can be raised and lowered between the two main line conveyor belts of the main line conveying structure, and can be raised to lift up the detection plate located on the two main line conveyor belts, and can be moved along the branch line direction. The jacked-up inspection plate is conveyed to the branch conveyor; the at least one branch conveyor belt is used for receiving the test disc from the at least one main bridge conveyor belt and conveying the test disc to the dispensing position along the branch line direction; Wherein, the at least one branch conveyor belt and the at least one main bridging conveyor belt can move the detection plate located at the dispensing position to the main line conveying structure opposite to the branch line direction. The dispensing device for molecular testing as claimed in claim 2, wherein The position of the at least one branch conveyor belt of the branch line conveying structure is higher than the position of the two main line conveyor belts of the main line conveying structure; The at least one main bridging conveyor belt of the branch conveyor structure can be moved upward to a height corresponding to the branch conveyor belt. The dispensing device for molecular testing according to claim 2, wherein the branch conveyor structure has at least one pair of bridge conveyor belts, which are arranged on one side of the two main line conveyor belts and located on the at least one main bridge conveyor belt between the at least one branch conveyor belt, and used for conveying the detection disc from the at least one main bridge conveyor belt to the at least one branch conveyor belt; the at least one auxiliary bridge conveyor belt and the at least one main bridge conveyor belt The belts are raised and lowered together, so that the height of the at least one pair of bridging conveyor belts selectively corresponds to the at least one branch conveyor belt. The dispensing device for molecular testing as claimed in claim 2, wherein The dispensing device for molecular testing has a test tray supply mechanism, which is provided on the base and has a disk rack for placing the test disk; a tray-carrying linear module, which has a tray-carrying slide, and the tray-carrying slide can be moved below the tray storage rack or below the two main line conveyor belts of the detection tray transfer mechanism; A tray lift module, which is arranged on the tray tray carriage of the tray tray linear module, and has a tray tray tray; the tray tray tray can move to the bottom of the tray rack along with the tray tray tray, and It can move upward to lift the test disk on the disk storage rack; the disk lift seat can be moved to between the two main line conveyor belts of the test disk transfer mechanism along with the disk transfer carriage, and can be downward moving to move the lifted test disk to the two main line conveyor belts of the test disk transfer mechanism. The dispensing device for molecular testing according to any one of claims 1 to 5, wherein the adapter tray supply mechanism has a stacking rack for placing the adapter tray, the bottom of the stacking rack is formed with a tray drop opening, the stack rack selectively allows the adapter tray on the stack rack to pass downward through the tray drop opening; A tray feeding module, which is arranged below the stacking frame, and is used to move the adapter tray passing through the tray opening to the tray body sliding seat of the tray body positioning mechanism; the tray feeding module has: a tray feeder seat, which is used to receive the adapter tray passing through the tray drop opening, and the tray feeder base can be moved to the bottom of the stacker and above the tray body sliding seat of the tray body positioning mechanism; The top surface of the disk body sliding seat of the disk body positioning mechanism is concavely provided with a accommodating groove; The disk body positioning mechanism has a disk lift plate, which is arranged in the accommodating groove of the disk body sliding seat, and can protrude upward from the accommodating groove to push up the disk feeding seat located above the disk body sliding seat. the adapter plate. The dispensing device for molecular testing according to any one of claims 1 to 5, further comprising: a shell, which is installed on the base and forms a refrigerating space, the disk positioning mechanism, the adapter disk supply mechanism, the drug injection mechanism, the detection disk transfer mechanism, the liquid pipetting mechanism and the sample disk input The mechanism is located in the refrigerating space; a sample tray input port and a detection tray output port are formed on the shell; an air conditioner installed in the refrigerated space and controlling the temperature of the refrigerated space; The specimen disc input mechanism has an input gripper, the input gripper can protrude from the specimen disc input port of the housing from the housing to clamp the specimen disc outside the housing into the housing; The test disk transfer mechanism has an output clamping claw, the output clamp can protrude from the test disk output port of the housing to clamp the test disk located on the test disk transfer mechanism to the outside of the case.

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