TWM604203U - Expandable microcapsule - Google Patents

Abstract

An expandable microcapsule with a core layer consisting of 300 parts by weight of foaming agent, 250 parts by weight of polymer water-absorbing material and 60 parts by weight of core layer lubricant, and the foaming agent can react with water to produce The characteristics of gas; and a coating layer is used to coat the surface of the core layer to form a granular structure. The coating layer is composed of 10% to 40% by weight of edible water-absorbent colloid and 5% to 40% of function Sexual health food additives, 2% to 30% emulsifier, 4% to 15% coating lubricant and 5% to 40% film coating composition, and the film coating composition has resistance to gastric acid decomposition and It can only be broken down in the intestine.

Description

Expandable microcapsule

This creation is an expandable microcapsule that can physically expand in the human stomach after eating to increase the feeling of fullness.

By the way, "obesity" usually refers to abnormal or excessive fat accumulation in the human body. According to the results of nutrition and health surveys, obesity can increase the burden of body functions, major risk factors for non-communicable diseases, and cause many chronic diseases. For example, It is easy to cause diseases such as arteriosclerosis, heart disease, stroke, cardiovascular disease, high blood pressure, hyperlipidemia, diabetes, malignant tumor, fatty liver, metabolic syndrome and so on.

Although drugs such as metabolic stimulants, appetite suppressants, and starch blockers can achieve weight loss in a short period of time, long-term use of drugs is bound to cause many adverse side effects to the human body. For example, the current legal weight loss drugs The ingredient Roche Fresh ^® (Orlistat ^® ) is an inhibitor of gastrointestinal pancreatic lipolytic enzymes, which can prevent part of the fat in food from being broken down and absorbed in the gastrointestinal tract, thereby reducing the amount of food from the food fat calories to achieve weight loss results, but Xenical ^® have great side effects include interference absorption of fat-soluble vitamins, oils stools, bloating, may also cause gallstones and liver and kidney damage, and therefore not suitable for long-term use; and another to Phentermine (topiramate) compound and lorcaserin (lorcaserin) as the main ingredients of weight loss drugs, its mechanism of action is to increase satiety, to suppress appetite to achieve the purpose of weight loss, but will There are other side effects such as dizziness, nausea or insomnia, constipation, and these two weight-loss drugs still have doubts about the risk of cardiovascular diseases, and they are not suitable for patients with cardiovascular diseases.

In view of this, how to solve the above-mentioned problems is the primary issue that this creation intends to solve.

The main purpose of this creation is to provide an expandable microcapsule, which has the characteristics of being physically swollen in the human stomach after consumption, and thereby can increase satiety and suppress appetite to achieve the purpose of weight loss, and Will not cause any adverse side effects of drugs to the human body.

In order to achieve the aforementioned purpose, this creation provides an expandable microcapsule, which contains: A core layer consisting of 300 parts by weight of foaming agent, 250 parts by weight of polymer water-absorbing material and 60 parts by weight of core layer lubricant, and the foaming agent has the characteristic of reacting with water to generate gas; A coating layer, covering the surface of the core layer to form a granular structure, the coating layer is composed of 10% to 40% by weight of edible water-absorbing colloid, 5% to 40% of functional health food additives , 2% to 30% emulsifier, 4% to 15% coating lubricant and 5% to 40% film coating composition, and the film coating composition has resistance to gastric acid decomposition and can only be in the intestine The decomposed characteristics of the Tao.

Preferably, in addition to directly consuming a predetermined amount of expandable microcapsules, the eater can physically expand in the human stomach to increase satiety and suppress appetite, and can also be made into tablets according to needs, or It is also possible to fill a predetermined amount of expandable microcapsules in a hollow capsule composed of two symmetrical half-capsules, so as to facilitate the consumption of the eater.

It is not difficult to gain an in-depth understanding of the above-mentioned objectives and advantages of this creation from the detailed description and drawings of the selected embodiments below.

First, please refer to Figures 1 and 2. An expandable microcapsule 10 provided by this creation is mainly composed of a core layer 11 and a coating layer 21 covering the surface of the core layer 11. :

The core layer 11 is composed of 300 parts by weight of foaming agent, 250 parts by weight of polymer water-absorbing material and 60 parts by weight of core layer lubricant, and the foaming agent has the characteristic of reacting with water to generate gas.

The coating layer 21 is used to cover the surface of the core layer 11 to form a granular structure. The coating layer 21 is composed of 10% to 40% by weight of edible water-absorbing colloid, 5% to 40% Functional health food additives, 2% to 30% emulsifier, 4% to 15% coating lubricant and 5% to 40% film coating composition, and the film coating composition has anti-gastric acid Decomposes and can only be broken down in the intestine.

In actual production, the foaming agent of this creation is composed of 100 to 300 parts by weight of acidic compounds and 130 to 410 parts by weight of basic compounds, and the foaming agent is heated at 40°C to 80°C before use. Dry under C conditions for 2 to 4 hours, and pass through a 40 to 100 mesh sieve. The acidic compound and the basic compound are preferably: 200 parts by weight of acidic compounds and 270 parts by weight of basic compounds; or 240 parts by weight of acidic compounds and 400 parts by weight of basic compounds; or 160 parts by weight of acidic compounds and 140 parts by weight of basic compounds. Copies.

Preferably, the above-mentioned acidic compound can be citric acid, tartaric acid, fumaric acid, adipic acid, malic acid, ascorbic acid, water-soluble amino acids (such as arginine), dilute hydrochloric acid, boric acid, sodium hydrogen tartrate, potassium hydrogen tartrate , Sodium hydrogen citrate, potassium hydrogen citrate, potassium dihydrogen phosphate, sodium dihydrogen phosphate, or any combination thereof. In addition, all edible organic acids, inorganic acids, and salts that are acidic after being dissolved in water can be used as acidic compounds. Among the acidic compounds, citric acid and/or tartaric acid are preferred.

Preferably, the above-mentioned basic compound may be one or any combination of sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, calcium carbonate, sodium glycine carbonate, and potassium glycine carbonate. In addition, all edible alkali metal or alkaline earth metal carbonates, percarbonates, bicarbonates and their mixed carbonates can be used as basic compounds that can generate carbon dioxide gas. Among the basic compounds, sodium carbonate and carbonic acid At least one of sodium hydrogen, potassium carbonate, and potassium hydrogen carbonate is preferred. In addition, considering that taking sodium-containing foaming agents multiple times a day will cause adverse consequences for consumers who are not suitable to eat more sodium, consider using less sodium carbonate and sodium bicarbonate instead of potassium bicarbonate, Potassium carbonate, calcium carbonate, zinc carbonate and other non-sodium or low-sodium carbon dioxide sources are substituted.

Preferably, the polymer water-absorbing material of the present invention is sodium polyacrylate, and the polymer water-absorbing material is superfinely pulverized to reach 300 meshes or more, and dried at 40°C to 80°C for 2 to 5 hours.

The core layer lubricant of this creation is mainly composed of 20 to 60 parts by weight of internal lubricant and 2 to 6 parts by weight of external lubricant. Preferably, the internal lubricant is polyethylene glycol 4000 or polyethylene glycol 6000, and the external lubricant is magnesium stearate, talc, or leucine L type or leucine DL type. Or any combination thereof, and the internal lubricant and external lubricant are preferably: 40 parts by weight of internal lubricant and 4 parts by weight of external lubricant, or 25 parts by weight of internal lubricant and 5 parts by weight of external lubricant , Or 57 parts by weight of internal lubricant and 3 parts by weight of external lubricant.

The preparation method of the creative core layer 11 is: mix the foaming agent, the polymer absorbent material, and the internal lubricant according to the above formula ratio, sieving (according to product requirements), mixing, and adding 240 parts by weight of anhydrous ethanol to make soft After being granulated by sieving (according to product requirements), dry at 40°C to 80°C to make the water content of the mixture particles below 3%, then sieving and finishing (according to product requirements), and then adding external lubrication After the agents are mixed, the granular core layer 11 of this creation can be obtained.

Next, the composition of the coating layer 21 of this creation is described as follows, among which:

The coating layer 21 is mainly composed of 10% to 40% by weight of edible water-absorbing colloid, 5% to 40% of functional health food additives, 2% to 30% of emulsifier, 4% to 15% of coating It is composed of layer lubricant and 5% to 40% film coating composition. The edible water-absorbent colloid in the coating layer 21 includes naturally occurring materials, such as plant secretions, seed gums and seaweed extracts, or may also be chemically modified materials, such as modified cellulose, starch or natural rubber derived Things. In a feasible embodiment, the edible water-absorbing colloid can be made of pectin, konjac powder, acacia gum, carrageenan, alginate, agar, Guanhua bean gum, xanthan gum, locust bean gum, gelatin, gellan gum ( gellangum), galactomannan, tragacanth, karaya gum, curdlan, chitosan, xyloglucan, β-glucan, furcellaran, dava Ghattigum, tamarin, bacterial gum, propylene glycol alginate, carboxymethyl locust bean gum, low methoxyl pectin, emulsified calcium and pectin mixture, modified microcrystalline cellulose, modified One of carboxymethyl cellulose (CMC), modified methyl cellulose (MC), modified hydroxypropyl methyl cellulose (HPCM) and modified hydroxypropyl cellulose (MPC) Or any combination thereof.

The functional health food additives in the coating layer 21 include, but are not limited to, cellulose, probiotics or vitamins that are beneficial to the human body, as well as all that can help digestion, increase metabolism, promote fat burning, help smooth bowel movements, inhibit sugars and Fat absorption and other beneficial additives to the human body.

The film coating composition in the coating layer 21 is designed to remain intact and not digested in the acidic environment of the stomach and can absorb water in the stomach, but it can be dissolved in the more alkaline environment of the intestine. The composition includes a film-forming agent, an anti-sticking agent and a solvent. Among them, the film forming agent may include, but is not limited to, shellac methyl cellulose, ethyl cellulose, propyl methyl cellulose, hydroxypropyl methyl cellulose phthalate (Hydroxypropyl Methyl Cellulose Phthalate; HPMCP) , Pectin, seaweed gum, sodium alginate, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl cellulose, polyvinylpyrrolidone, polyethylene glycol, aminoalkyl methacrylate copolymer Any one or any combination of the substance, maltodextrin and polydextrose. Preferably, the film-forming agent with stomach insolubility is sodium alginate. In addition, based on 100% by weight of the film coating composition, the film coating composition contains 1% to 25% of film forming agent, 0.5% to 15% of anti-sticking agent, and 60% to 95% of solvent.

In addition, an emulsifier can be further added to the coating layer 21, the mass ratio of the edible water-absorbing colloid to the emulsifier can be 7:1, and the emulsifier can be particularly selected from lecithin, fatty esters of glycerol, sucrose or sorbose Alcohol can be used in the environment where there is a high content of protein or oil. Furthermore, according to production needs, a coating layer lubricant that is convenient for granulation is added, and the coating layer lubricant is polyethylene glycol 4000, polyethylene glycol 6000, sodium lauryl sulfate, and lauryl sulfate Magnesium, L-leucine, sodium benzoate, sodium oleate, sodium chloride, sodium acetate, boric acid, magnesium stearate, talc, micronized silica gel, sucrose fatty acid ester and sodium stearyl fumarate, leucine One or any combination of acid L type or leucine DL type.

Preferably, the method for covering the surface of the core layer with the inventive coating layer 21 can be made into a granular structure by using conventional pharmacological techniques. Conventional pharmacological techniques include, for example, one or a combination of the following methods: (1) dry mixing, (2) direct compression, (3) grinding, (4) dry or non-aqueous granulation, (5) wet granulation , (6) Melting, or (7) Extrusion/Spheronization; other methods such as commonly used solvent evaporation methods (such as: spray drying, layered or fluidized bed granulation, rotating disc, three-phase emulsification technology, etc.), Suitable solvents for solvent evaporation include alcohols (e.g. methanol, ethanol, n-propanol, isopropanol and butanol), ketones (e.g. acetone, methyl ethyl ketone and methyl isobutyl ketone) ), esters (such as ethyl acetate and propyl acetate) and various other solvents, such as isopropyl ether, acetonitrile, dichloromethane, chloroform, hexane, toluene, tetrahydrofuran, cyclic ethers, and 1, 1,1-Trichloroethane; low volatility solvents can also be used, such as dimethyl acetamide or dimethyl sulfide. Mixtures of solvents can also be used, such as a mixture of 20% ethanol and 80% acetone and water.

The swellable microcapsule 10 of the original creation made with the above-mentioned components can remove the water generated by the inevitable acid-base reaction in time by adding a polymer water-absorbing material to the core layer 11 to make the core layer foam The surface of the particles of the agent can be isolated and kept in a dry state to prevent the acid-base reaction, thereby solving the problem of easy moisture absorption and instability of the foaming agent, and under actual action, it can ensure that the foaming agent foams after absorbing water The effect of fast speed, on the other hand, after absorbing water through the polymer absorbent material, it can help stabilize the colloidal shape of the coating layer, and has an excellent molding effect.

When the swellable microcapsule 10 of the present creation enters the human stomach after being eaten, the edible water-absorbing colloid of the coating layer 21 will soften after absorbing water, and the core layer 11 will also swell due to the absorption of water. Because the foaming agent in the core layer 11 reacts with water to produce carbon dioxide, the coating layer 21 covering the core layer 11 can be blown by the continuous carbon dioxide generated by the foaming agent and rapidly expand and become larger (as shown in Figure 2). ), in this way, the effect of physical swelling can be achieved, and thereby, the satiety of the eater can be greatly increased, thereby suppressing appetite; on the other hand, the film with a specific composition in the coating layer 21 The clothing composition will not decompose and collapse in the acid environment of the stomach, so it can maintain its swelled body in the stomach, but when it enters the more alkaline environment of the intestine, it will begin to disintegrate. Therefore, when the eater consumes this creation, it can swell slightly. When the capsule 10 is used, the functional health food additives contained in the coating layer 21 can be delayed until the release of the intestinal tract without being decomposed and destroyed by gastric acid, thereby increasing the concentration absorbed by the body to enhance its efficacy . The expandable microcapsules provided by this creation have the characteristics of physical expansion in the human stomach, and thereby can increase satiety and suppress appetite, so as to achieve the purpose of weight loss, and it does not contain any pharmaceutical ingredients. It can ensure that it will not cause any adverse side effects to the human body.

In addition, in the practical application of the expandable microcapsules provided by this creation, users can directly consume a predetermined number of expandable microcapsules 10, so that they can physically expand in the human stomach to increase satiety and suppress appetite , A predetermined number of expandable microcapsules 10 can also be made into a tablet shape as shown in Figure 3 by adding appropriate binders and organic solvents according to the aforementioned conventional pharmacological techniques according to requirements, so as to facilitate the consumption of the edible, wherein the binding The agent is used to impart the effect of binding a plurality of expandable microcapsules 10 to each other, and includes, for example, alginic acid and its salts; cellulose derivatives, such as carboxymethyl cellulose, methyl cellulose, and hydroxypropyl methyl cellulose , Hydroxyethyl cellulose, hydroxypropyl cellulose, ethyl cellulose (for example, microcrystalline cellulose; microcrystalline dextrose; amylose; magnesium aluminum silicate; polysaccharide acid; bentonite; gelatin; polyvinyl Pyrolidone/vinyl acetate copolymer; crospovidone; povidone; starch; pregelatinized starch; tragacanth gum; dextrin; sugars, such as sucrose, glucose, dextrose, molasses, mannitol , Sorbitol, xylitol and lactose; natural or synthetic gums, such as acacia, tragacanth, ghatti gum, povidone, Isabelle husk mucus; polyvinylpyrrole Pyridone, polymethacrylate, pine polysaccharide, polyethylene glycol, propylene glycol, polyethylene oxide, wax, sodium alginate also include (for example), agar, alginic acid, carbomer, carrageenan, guar Gum, cellulose acetate phthalate, stearic acid, ceratonia, povidone, or any combination thereof. The organic solvent can be selected from ethanol, isopropanol, Tetrahydrofuran, isopropyl ether, acetone, methyl ethyl ketone, methylene chloride or a mixture of these solvents.

In addition, as shown in Fig. 4 in another embodiment of the present creation, a predetermined number of expandable microcapsules 10 can also be filled in the hollow capsule 3 composed of two symmetrical half-capsules 31, 32 butted. In order to facilitate the consumption of the edible, the hollow capsule 3 contains gelatin or vegetable ingredients that can be absorbed by the human body, such as methyl cellulose, hydroxypropyl cellulose, and propyl methyl cellulose.

However, the disclosure of the above embodiments is only used to illustrate the creation, not to limit the creation, so any changes in values or replacement of equivalent components should still belong to the scope of the creation.

To sum up, when people who are familiar with this art know that this creation can indeed achieve the aforementioned purpose, and that it has actually complied with the provisions of the Patent Law, they should file an application in accordance with the law.

10: Expandable microcapsules 11: core layer 21: Cladding 31, 32: half cyst 30: Hollow capsule

Figure 1 is a schematic diagram of the composition structure of the created expandable microcapsule. Figure 2 is a schematic diagram of the physical expansion of the created expandable microcapsules. Figure 3 is a schematic diagram of the composition structure of the creation made into ingots. Figure 4 is a schematic diagram of the composition structure of another implementation aspect of the creation.

10: Expandable microcapsules

11: core layer

21: Cladding

Claims (9)

An expandable microcapsule containing: A core layer consisting of 300 parts by weight of foaming agent, 250 parts by weight of polymer water-absorbing material and 60 parts by weight of core layer lubricant, and the foaming agent has the characteristic of reacting with water to generate gas; A coating layer is coated on the surface of the core to form a granular structure. The coating layer is composed of 10% to 40% by weight of edible water-absorbent colloid, 5% to 40% of functional health food additives, 2% to 30% emulsifier, 4% to 15% coating lubricant and 5% to 40% film coating composition, and the film coating composition is resistant to gastric acid decomposition and can only be in the intestine The characteristic of being decomposed. The expandable microcapsule according to claim 1, wherein the blowing agent is composed of 100 to 300 parts by weight of an acidic compound and 130 to 410 parts by weight of a basic compound, and the acidic compound is at least citric acid or tartaric acid. One of them is composed, and the basic compound is composed of at least one of sodium carbonate, sodium bicarbonate, potassium carbonate, and potassium bicarbonate. The expandable microcapsule according to claim 1, wherein the polymer water-absorbing material is sodium polyacrylate, and the polymer water-absorbing material is superfinely pulverized to 300 meshes or more, and dried at 40°C to 80°C To 5 hours. The expandable microcapsule according to claim 1, wherein the core layer lubricant is composed of 20 to 60 parts by weight of an internal lubricant and 2 to 6 parts by weight of an external lubricant, and the internal lubricant is composed of One or a combination of polyethylene glycol 4000 or polyethylene glycol 6000, and the external lubricant is composed of magnesium stearate, talc, or one of leucine L type or leucine DL type or Compose of any combination. The expandable microcapsules according to claim 4, wherein the foaming agent, the polymer absorbent material, and the internal lubricant are mixed, and 240 parts by weight of the soft material made of absolute ethanol are added, and after sieving and granulating, Dry under the condition of 40°C to 80°C to make the water content of the mixture particles below 3%, then add additional lubricant and mix well to prepare the core layer. The expandable microcapsule according to claim 1, wherein the edible water-absorbing colloid is composed of pectin, konjac powder, gum arabic, carrageenan, alginate, agar, Guanhua bean gum, xanthan gum, locust bean Gum, gelatin, gellan gum, galactomannan, tragacanth gum, karaya gum, keratin gum, chitosan, xyloglucan, β-glucan, fucoidan, dava gum , Bib gum, bacterial gum, propylene glycol alginate, carboxymethyl locust bean gum, low methoxy pectin, emulsified calcium and pectin mixture, modified microcrystalline cellulose, modified carboxymethyl cellulose , Modified methyl cellulose, modified hydroxypropyl methyl cellulose, modified hydroxypropyl cellulose, or any combination thereof. The expandable microcapsule according to claim 1, wherein the film coating composition is composed of 1% to 25% by weight of film-forming agent, 0.5% to 15% of anti-sticking agent, and 60% to 95% of solvent It is composed of shellac methyl cellulose, ethyl cellulose, propyl methyl cellulose, hydroxypropyl methyl cellulose phthalate, pectin, seaweed gum, and alginic acid Sodium, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl cellulose, polyvinylpyrrolidone, polyethylene glycol, aminoalkyl methacrylate copolymer, maltodextrin and polydextrose One or any combination of them. The expandable microcapsule according to claim 1, wherein the emulsifier is selected from one of lecithin, fatty ester of glycerol, sucrose, or sorbitol. The expandable microcapsule according to claim 1, wherein the coating lubricant is made of polyethylene glycol 4000, polyethylene glycol 6000, sodium lauryl sulfate, magnesium lauryl sulfate, L-light Acid, sodium benzoate, sodium oleate, sodium chloride, sodium acetate, boric acid, magnesium stearate, talc, micronized silica gel, sucrose fatty acid ester and sodium stearyl fumarate, leucine L-type or bright It is composed of one or any combination of amino acid DL type.

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