TWM572746U - A coated structure for preventing glutathione oxidation - Google Patents

Abstract

Glutathione is a well-known antioxidant natural substance that helps cells capture free radicals to prevent major molecules in the cell from being destroyed by oxidative stress, causing related diseases. The present invention relates to a multilayer embedding structure for embedding glutathione to prevent oxidation, comprising a glutathione powder core, a fat layer, a protein layer and a waterproof layer. The powdery core is composed of glutathione powder, which is released into the blood after being released into the intestine and transported to the whole body cells, thereby enhancing the antioxidant effect of the cells. The fat layer is on the surface of the glutathione powder core, which separates glutathione from the air to prevent oxidation of glutathione, protects the powder from dissolving and dispersing in the intestine, and has anti-gastric acid and intestinal choline. The effect. The protein layer is coated and fixed on the outer surface of the fat layer and has the function of competing active oxygen to protect the glutathione from oxidation. The waterproof layer is coated and fixed on the outer surface of the protein layer, so that the embedding agent is not easily dispersed in the aqueous solution and is not damaged by gastric acid and bile salts. Through the layered structure design of preventing glutathione oxidation, the coated glutathione powder can be released and absorbed in the intestinal tract, and after absorption in the intestinal tract, it enters the tissue fluid and blood, and is transported to the whole body cell to strengthen the cell resistance. Oxidation function.

Description

Embedding structure for preventing oxidation of glutathione

This work is about the technical field of an embedded structure for preventing oxidation of glutathione.

Glutathione (GSH), also known as glutathione (GSH), has a molecular weight of 307 g/mol, consisting of glutamic acid (glutamate), cysteine (cysteine) and A small molecule peptide (tripeptide) composed of three amino acids of glycine is also a thiol. Generally present in high concentrations of cells in eukaryotes, it is the most abundant antioxidant in the cell. However, the cells are subject to aging, injury and other factors, and the content will gradually decrease, thus failing to effectively protect the cells from free radicals or various oxidizing substances. Appropriate supplementation can strengthen the cell's antioxidant capacity.

Glutathione exists in two forms in the body, one is reduced (GSH) and has antioxidant capacity. When the reduced type absorbs free radicals or acts as an oxidized species, it produces a disulfide bond to form a double-body glutathione disulfide (GSSG). The oxidized glutathione is involved in the glutathione with the participation of NADPH coenzyme. Glutathione reductase (GSH-Rx) is reduced to GSH and can be reused; while oxidized form is glutathione by Glutathione peroxidase (GSH-Px) or oxidizing substances. It is oxidized to GSSG.

Both types of glutathione are present in the body, forming a dynamic balance to maintain a certain The amount, and mutual conversion, constitutes an effective antioxidant system, in which the proportion of reduced glutathione is relatively high, accounting for about 90%.

Some bacteria can produce glutathione, and most mammals and plant cells can also synthesize themselves. Glutathione is a small molecule peptide or thiol composed of three amino acids, glutamic acid, cysteine and glycine.

Cell synthesis of glutathione is a step involved by two ATP energy providing molecules. First, glutamate and cysteine are joined by an enzyme called gamma-glutamylcysteine synthetase, or glutamate cysteine. Ligase, GCL), followed by glycine acid glutathione synthetase followed by the dipeptide synthesized in the first step, thus synthesizing glutathione.

Glutathione is known to be an important antioxidant in the cell, protecting important molecules in cells from free radical damage, including nucleic acids, proteins, lipids, etc., in order to maintain the normal functioning of cells.

This work is about the technical field of an embedded structure for preventing oxidation of glutathione.

The present invention relates to a multilayer embedding structure for embedding glutathione to prevent oxidation, comprising a glutathione powder core, a fat layer, a protein layer and a waterproof layer.

The core is composed of an antioxidant powder glutathione powder, which is transported to the whole body cells via the blood after absorption in the intestinal tract to provide cytoprotection.

The fat layer is coated and fixed on the surface of the glutathione powder core to isolate glutathione from air to prevent oxidation of glutathione and protect the powder from dissolving and dispersing in the intestinal tract. It has anti-gastric acid and intestinal choline effects. The protein layer is coated and fixed on the outer surface of the fat layer and has the function of competing active oxygen to protect the glutathione from oxidation. The waterproof layer is coated and fixed on the outer surface of the protein layer, so that the embedding agent is not easily dispersed in the aqueous solution and is not damaged by gastric acid and bile salts.

Through the layered structure design of preventing glutathione oxidation, the coated glutathione powder can be released and absorbed in the intestinal tract, and after absorption in the intestinal tract, it enters the tissue fluid and blood, and is transported to the whole body cell to strengthen the cell resistance. Oxidation function.

3‧‧‧Embedded structure to prevent oxidation of glutathione

31‧‧‧Waterproof layer

32‧‧‧protein layer

33‧‧‧Fat layer

34‧‧‧ glutathione powder core

BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 is a side elevational view of a preferred embodiment of an embedding structure for preventing oxidation of glutathione.

Referring to Fig. 1, the present invention is a dosage form formed by an embedding structure for preventing oxidation of glutathione, which can be used orally and comprises a waterproof layer, a protein layer, a fat layer and a glutathione. Powder core.

The waterproof layer can be used in a variety of fatty acid compositions ranging in thickness from 0.1 to 10 μm. The protein layer can use natural vegetable protein or animal protein, and the thickness ranges from 0.1 to 10 μm. The fat layer can be used with vegetable or animal fats and has a thickness ranging from 0.1 to 20 μm.

The embedding method can embed glutathione core powder layer by layer using a flow spray.

Claims (2)

An embedding structure for preventing oxidation of glutathione, for oral consumption, and comprising a glutathione powder core, a fat layer, a protein layer and a waterproof layer, the glutathione powder core is a glutathione powder composition, the fat layer is coated and fixed on the outer surface of the core of the glutathione powder, and the protein layer is coated and fixed on the outer surface of the fat layer, and the waterproof layer is coated and fixed on the outer surface of the protein layer . An embedding structure for preventing oxidation of glutathione according to claim 1, wherein the waterproof layer has a thickness ranging from 0.1 to 10 μm, and the protein layer has a thickness ranging from 0.1 to 10 μm. The thickness of the layer ranges from 0.1 to 20 μm.