TWM567074U - Tissue fluorescence-guided image and photonic treatment system - Google Patents

Abstract

A system includes a fluorescent material, a photonic treatment control device, an illuminating device, a camera device and a display device. The fluorescent material is pre-injected into a tissue area. The illuminating device is operated to illuminate with a predetermined wavelength of light on the tissue area to fluoresce the fluorescent material to seek and mark a treatment position which is corresponding with the tissue area where the fluorescent material exists. The camera device is operated to capture the treatment position to output a fluorescence-marked image. The display device is in wired or wireless communication with the camera device to receive and display the fluorescence-marked image. According to the fluorescence-marked image, the illuminating device is operated to project a predetermined power of light on the treatment position.

Description

Tissue fluorescent positioning image and illumination processing system

This creation is about a tissue-fluorescence-guided image and photonic treatment system; in particular, it relates to a tumor, tissue tumor, hemangioma or organ tissue fluorescence localization image and illumination treatment. system.

A conventional laser tumor treatment apparatus, such as the laser-excited nanoparticle tumor therapeutic apparatus 〞 invention patent application of the Republic of China Patent Publication No. 201039881, which discloses a laser-activated nanoparticle tumor therapeutic apparatus. The nanoparticle tumor therapeutic apparatus comprises a laser device, a handle, a transmission fiber and a temperature control automatic system, and a laser light output by the laser device transmits energy to a tumor tissue via the handle.

The handle comprises a focus lens group, and the focus lens group is used to control the spot size and shape [parallel or focus] of the output light of the transmission fiber. The handle further includes a shutter and a two-dimensional scanner, and the energy of the laser light is transmitted to the tumor tissue via scanning for large-area treatment. The tumor tissue is directly injected into the tumor tissue via intratumoral injection or arterial injection, and is concentrated in the interior of the tumor tissue, or via an optical fiber-guided endoscope for the treatment of visceral tumors.

In addition, the temperature control automatic system includes a plurality of thermocouples, a thermometer, and a temperature signal feedback device. Connect the temperature signal feedback device To an electronically controlled motor to control the opening or closing of the shutter, or to connect the temperature signal feedback device to the laser device to directly control the power switch of the output light for generating a continuous pulse output Light. The temperature control automatic system further includes an infrared sensor, and the infrared sensor is configured to detect a surface layer temperature of the tumor tissue, and is connected to the signal feedback device via a signal connection line.

Another conventional laser tumor treatment device, such as the illuminating multi-wavelength fiber laser multi-function medical instrument 〞 invention patent application of the Republic of China Patent Publication No. 201039880, discloses a visible light multi-wavelength fiber laser multi-function medical instrument. The fiber laser multi-function medical instrument comprises a power source, a plurality of different wavelengths of laser light and an electric controller. The plurality of different wavelengths of laser light are respectively coupled to the plurality of inner transmission fibers via a focusing mirror, and finally the plurality of inner transmission fibers are bundled into a bundle. The output light of the bundle is coupled to an external transmission fiber via a focusing mirror and an SMA connector.

The plurality of different wavelengths of the laser light are a visible light laser, and the visible light laser has a wavelength range of 420 nm to 680 nm. The visible light laser comprises any two selected from the group consisting of red light (wavelength range 635-680 nm), yellow light [wavelength range 560-590 nm], green light [wavelength range 525-540 nm], and blue light [wavelength range 430-490 nm]. The above different wavelengths. In addition, the electronic controller is configured to select the multi-wavelength output light of the external transmission fiber, and the multi-wavelength output light can be output simultaneously or individually.

However, the nanoparticle tumor therapeutic apparatus of the aforementioned Republic of China Patent Publication No. 201039881 and the optical laser multifunctional medical apparatus of No. 201039880 are still only the construction of a general laser tumor treatment apparatus, and therefore it is inevitably further provided. The need for various other improvements (eg, tissue-focused image processing or illumination processing). The above-mentioned publications No. 201039881 and No. 201039880 are only for reference to the background of the present invention and the state of the art is not limited to the scope of the present invention.

In view of the above, the present invention provides a tissue fluorescent positioning image and illumination processing system for injecting a fluorescent substance into a predetermined tissue area by using a standard, and using a light irradiation device to make a first reservation. The wavelength light is irradiated on the predetermined tissue area, so that the fluorescent display of the fluorescent substance is used to find and mark at least one position to be illuminated, and the position to be illuminated is photographed by using a photographing device to position the light to be processed. Appropriately displayed on a display device, and then using a second predetermined wavelength of light or the first predetermined wavelength of light to switch illumination to the position to be illuminated at a predetermined power to improve the operation of the conventional fluorescent positioning image and the illumination processing operation problem.

The main purpose of the present invention is to provide a tissue fluorescence localization image and illumination processing system that uses a target to inject a fluorescent substance into a predetermined tissue area and irradiate the light with a first predetermined wavelength by a light irradiation device. Determining a tissue area for searching and marking at least one position to be illuminated by the fluorescent display of the indicator fluorescent substance, and photographing the position to be illuminated by a photographing device to appropriately display the position to be illuminated to be displayed on a display The device further uses a second predetermined wavelength of light or the first predetermined wavelength of light to switch illumination to the to-be-illuminated processing position with a predetermined power of light to achieve accurate positioning of the to-be-processed position and improvement of the laser processing operation.

In order to achieve the above object, the tissue fluorescent positioning image and illumination processing system of the preferred embodiment of the present invention comprises: at least one indicator fluorescent substance pre-injected into a predetermined tissue area in an appropriate manner; a light control host, Transmitting at least one automatic control command; at least one light illumination device connected to the illumination control host by wire or wirelessly, and the light illumination device is at a first predetermined wave Long light is incident on the predetermined tissue area to display, find and mark a position to be illuminated by the fluorescent light of the indicator, and the position to be illuminated is located in the predetermined tissue area, and the indicator is fluorescent The material may flow to the predetermined tissue area; at least one photographic device is connected to the illumination control host by wire or wirelessly, and the photographic device is configured to photograph the position to be illuminated to output a to-be-processed position image; At least one display device connected to the illumination control host by wire or wirelessly, so as to properly receive the image of the to-be-processed position from the camera device, and display the image of the to-be-processed position on the display device; wherein the light is illuminated The device and the photographic device are disposed on an illumination handheld device, so that when the light illumination device of the illumination handheld device is irradiated to the predetermined tissue region, the photographic device of the illumination handheld device takes the image of the to-be-processed location, and the image is to be processed The position image is switched by the light illumination device of the illumination handheld device to a second predetermined wavelength of light or A first light at a predetermined wavelength is irradiated to the predetermined power of the light to be light treatment position.

In order to achieve the above object, the tissue fluorescent positioning image and illumination processing system of the preferred embodiment of the present invention comprises: at least one indicator fluorescent substance pre-injected into a predetermined tissue area in an appropriate manner; a light control host, Transmitting at least one automatic control command; at least one light illumination device connected to the illumination control host in a wired or wireless manner, and the light illumination device is irradiated to the predetermined tissue region with a first predetermined wavelength of light to utilize the target Fluorescently displaying, finding and indicating a position to be illuminated, wherein the position to be illuminated is located in the predetermined tissue area, and the indicator fluorescent substance can flow to the predetermined tissue area; at least one photographic device , which is connected by wire or wirelessly Controlling the host by the illumination, and the photographing device is configured to photograph the position to be processed to output a position image to be processed; and at least one display device is connected to the illumination control host by wire or wirelessly, so as to The photographing device appropriately receives the image of the to-be-processed position, and displays the image of the to-be-processed position on the display device; wherein the light-illuminating device and the photographing device are disposed on an endoscope device so as to be in the endoscope device When the light irradiation device is irradiated to the predetermined tissue region, the image of the image to be processed is taken by the image capturing device of the endoscope device, and the light irradiation device of the image device is switched according to the image to be processed to a second predetermined The wavelength light or the first predetermined wavelength light is illuminated by the predetermined power light at the position to be illuminated.

In order to achieve the above object, the tissue fluorescent positioning image and illumination processing system of the preferred embodiment of the present invention comprises: at least one indicator fluorescent substance pre-injected into a predetermined tissue area in an appropriate manner; a light control host, Transmitting at least one automatic control command; at least one light illumination device connected to the illumination control host in a wired or wireless manner, and the light illumination device is irradiated to the predetermined tissue region with a first predetermined wavelength of light to utilize the target Fluorescently displaying, finding and indicating a position to be illuminated, wherein the position to be illuminated is located in the predetermined tissue area, and the indicator fluorescent substance can flow to the predetermined tissue area; at least one photographic device And communicating with the illumination control host by wire or wirelessly, and the photographing device is configured to photograph the illumination to be processed position to output a to-be-processed position image; and at least one display device that connects the communication by wire or wirelessly Controlling the host with the illumination to properly receive the image of the to-be-processed position from the photographing device, and Pending position of the image displayed on the display device; When the light irradiation device is irradiated to the predetermined tissue region, the image of the image to be processed is taken by the image capturing device, and the light is irradiated by the light irradiation device according to the image to be processed to switch to a second predetermined wavelength or the first predetermined The wavelength light is illuminated by the predetermined power light at the position to be illuminated.

The light illumination device of the preferred embodiment of the present invention is selected from the group consisting of an LED device, a LASER device, or a fiber optic illumination device.

The photographing device of the preferred embodiment of the present invention is selected from a digital photographing device or an infrared photographing device.

The photographic device of the preferred embodiment further includes an image processing unit, and the image processing unit is configured to process the image of the to-be-processed location.

The display device of the preferred embodiment of the present invention comprises a computer screen display, a flat panel display, a mobile phone display, a television display or any combination thereof.

The illumination handheld device of the preferred embodiment of the present invention has a side operation window for the light illumination device and the photographing device to perform a light irradiation operation and a photographing operation through the side operation window.

The endoscope device of the preferred embodiment of the present invention comprises an illumination fiber or a halogen lamp fiber.

The endoscope device of the preferred embodiment of the present invention is selected from the group consisting of a cystoscope, a bowel mirror, a gastroscope, a colonoscopy, a bronchoscope, a laparoscope, a capsule endoscope or other endoscope.

100‧‧‧Light control host

101‧‧‧Endoscope device

102‧‧‧Endoscope tube

103‧‧‧Switch button

1A‧‧‧Light handheld device

1B‧‧‧Light handheld device

1C‧‧‧Light handheld device

10‧‧‧Lighting device

10a‧‧‧Lighting device

10b‧‧‧Different wavelength light illumination modules

10c‧‧‧White light illumination module

11‧‧‧Photographing device

11a‧‧‧Photographing device

11b‧‧‧Photography module

12‧‧‧ side operation window

13‧‧‧ bottom opening

2‧‧‧Display device

9‧‧‧ Target fluorescent substance

Figure 1 is a schematic diagram of a tissue fluorescence localization image and illumination processing system of the first preferred embodiment of the present invention.

Fig. 1A is a schematic view showing the use of an endoscope device for the tissue fluorescence localization image and illumination processing system of the first preferred embodiment of the present invention.

Fig. 2 is a schematic view showing the tissue fluorescence localization image and illumination processing system of the second preferred embodiment of the present invention.

Fig. 3 is a schematic view showing the tissue fluorescence localization image and illumination processing system of the third preferred embodiment of the present invention.

Fig. 4 is a schematic view showing the tissue fluorescence localization image and illumination processing system of the preferred embodiment of the present invention.

Fig. 5 is a schematic view showing the use of a light irradiation device for the tissue fluorescence localization image and illumination processing system of the preferred embodiment of the present invention.

Fig. 6 is a schematic view showing another embodiment of the light-emitting positioning image and illumination processing system of the preferred embodiment of the present invention.

In order to fully understand the present invention, the preferred embodiments are described in detail below with reference to the drawings, and are not intended to limit the present invention.

The tissue fluorescence localization image and illumination processing system of the preferred embodiment of the present invention is suitable for or assisting various tumors (or tissue tumors, hemangiomas and other tumors), fluorescent imaging examination or detection system, tumor [or tissue tumor, blood vessel Tumor and other tumors] Fluorescent image processing (eg, spray treatment) systems or tumors [or tissue tumors, hemangiomas, and other types of tumors] fluorescence imaging surgery (eg, laser treatment) system, but it is not Used to limit the scope of application of this creation.

FIG. 1 is a schematic diagram showing a tissue fluorescence localization image and illumination processing system according to a first preferred embodiment of the present invention. Referring to FIG. 1 , the tissue fluorescent positioning image and illumination processing system of the first preferred embodiment of the present invention comprises a target fluorescent substance 9 , a light control host 100 , and an endoscope device. 101. A light irradiation device 10, a photographing device 11, and a display device 2.

Referring to FIG. 1 again, for example, the light irradiation device 10 and the imaging device 11 are integrated on the endoscope device 101. Using the light irradiation device 10 to light at different wavelengths [first predetermined wavelength light] Irradiating on a predetermined tissue area, or controlling the light irradiation device 10 appropriately by the light control host 100, so that the light irradiation device 10 performs illumination processing of a light to be processed position by switching different wavelengths of light [second predetermined wavelength light] .

FIG. 1A is a schematic diagram showing the use of an endoscope device for the tissue fluorescence localization image and illumination processing system of the first preferred embodiment of the present invention. Please refer to FIG. 1A. For example, the endoscope device 101 is selected from the group consisting of a cystoscope, a bowel mirror, a gastroscope, a colonoscopy, a bronchoscope, a laparoscope, a capsule endoscope or the like. An endoscope, and the endoscope device 101 includes an endoscope tube 102, an illumination fiber or a halogen fiber, and the endoscope tube (hose or tube) 102 (shown by a broken line) Extend into a human esophagus [not labeled] or other body conduits (eg, digestive tract, urethra, vagina, veins, or other human organs).

FIG. 2 is a schematic diagram showing the tissue fluorescence localization image and illumination processing system of the second preferred embodiment of the present invention. Referring to FIG. 2, the tissue fluorescent positioning image and illumination processing system of the second preferred embodiment of the present invention comprises a target fluorescent substance 9, a light control host 100, and a hand-held device. 1A, a light irradiation device 10, a photographing device 11, and a display device 2.

Referring again to FIG. 2, for example, the target fluorescent substance 9 is pre-injected into a predetermined tissue region in an appropriate manner [vessel or affected subcutaneous tissue] [various tumor regions, tissue regions, hemangioma regions Or other tumor area] and finally present in the predetermined tissue area, and the target fluorescent substance 9 comprises indocyanine green, bacteriochlorin, chloro-e6-chlorophyll complex Chlorin-e6-Chlrophyllin-A-Zinc-complex], texaphyrin or other photosensitizer (for example: surface plasma resonance excitation or photosensitizer).

Please refer to Figure 2 again, for example, the lighting control The host 100 is selected from an automatic illumination control host or a similarly controlled illumination control host, and can issue at least one automatic control command, so that the illumination control host 100 can be used to perform appropriate operations to control the illumination handheld device 1A and the light illumination device. Shooting optical fiber or LED laser] 10. Photographic device 11 and display device 2 for performing a series of tissue [various tumors, arteries, veins or blood vessels] fluorescence localization imaging operations similar to the retention of the target fluorescent substance 9 test.

Referring to FIG. 2 again, for example, the illumination handheld device 1A is configured to connect the light illumination device [optical fiber laser or diode laser] 10 and the photographing device 11 so that the operator can directly use the light. The illumination handheld device 1A performs a series of tissue (various tumors, arteries, veins or blood vessels) fluorescence localization imaging operations.

Referring to FIG. 2 again, for example, the light irradiation device 10 is selected from an LED device, a LASER device, or a fiber optic illumination device, and the light illumination device 10 is connected to the illumination control by wire or wirelessly. Host 100. The light irradiation device 10 is at a first predetermined wavelength (for example, 355 nm to 1350 nm or 635 nm to 1350 nm, and its power is between 0.1 W and 0.5 W) when the image is imaged by fluorescence of various tissues, arteries, veins, or blood vessels. Light is irradiated on the predetermined tissue region (the human tissue structure is not shown), so that the fluorescent light of the target fluorescent substance 9 is used to display, find and mark a position to be treated (or a tumor position), and the position to be illuminated is processed. Corresponding to the predetermined tissue region, and the target fluorescent substance 9 can flow to the predetermined tissue region and finally exist in the predetermined tissue region.

Referring to FIG. 2 again, for example, the photographing device 11 is selected from a digital photographing device, an infrared photographing device or other photographing device such as a CCD, a Cmos, and the photographing device 11 Connected to the illumination control host 100 in a wired or wireless manner, and the photographing device 11 is configured to photograph the position to be processed to output a position image to be processed (or various tumor position images, various arteries, veins or Vascular position image]. In addition, the camera device 11 further includes an image processing unit, and the image processing unit is configured to process the image of the to-be-processed position.

Referring to FIG. 2 again, for example, the display device 2 includes a computer screen display, a flat panel display, a mobile phone display, a television display, any combination thereof, or an arbitrary display (eg, a mobile communication device). Or the display device 2, and the display device 2 is connected to the illumination control host 100 by wire or wirelessly, so as to properly receive the image of the to-be-processed position from the camera device 11, and display the image of the to-be-processed position on the display. On device 2.

Referring to FIG. 2 again, for example, when the light irradiation device 10 of the illumination handheld device 1A is irradiated to the predetermined tissue region, the imaging device 11 of the illumination handheld device 1A captures the image of the to-be-processed position, and According to the image to be processed, the light irradiation device 10 of the illumination handheld device 1A switches between a second predetermined wavelength of light (for example, between 355 nm and 1500 nm) or the first predetermined wavelength of light with a predetermined power (for example, 1 W). The above] is irradiated to the position to be illuminated.

FIG. 3 is a schematic diagram showing the tissue fluorescence localization image and illumination processing system of the third preferred embodiment of the present invention. Referring to the second and third embodiments, in contrast to the second embodiment, the light-emitting device 10 and the photographing device 11 are integrally connected to a light-emitting handheld device 1A for holding in the light. When the light irradiation device 10 of the device 1A is irradiated to the predetermined tissue region, the imaging device 11 of the illumination handheld device 1A captures the image of the to-be-processed position. In addition, the illumination handheld device 1A includes a switch button 103 and a grip portion, and the switch button 103 is configured to switch the different wavelengths of illumination light of the light illumination device 10, and the grip portion has a reduced radius grip portion. Therefore, the user can easily hold the light handheld device 1A.

FIG. 4 is a schematic diagram showing a tissue fluorescence localization image and illumination processing system according to a fourth preferred embodiment of the present invention. Referring to FIG. 4, the light-emitting device of the fourth preferred embodiment of the present invention is compared with the second embodiment. [Example: fiber laser or LED laser] 10a and the photographing device 11a are integrally connected to an illumination handheld device 1B. In addition, the illumination handheld device 1B includes a side operation window 12 and a bottom opening 13 on the side wall of the illumination handheld device 1B, and the bottom opening 13 is located in one of the illumination handheld devices 1B. a bottom end, so that when the light irradiation device 10a of the illumination handheld device 1B is irradiated to the predetermined tissue region via the side operation window 12, the photographing device 11a of the illumination handheld device 1B ingests the to-be-processed position via the side operation window 12 The image (or any photographic operation) or the light illuminating device 10a of the illumination handheld device 1B switches the illumination processing to the position to be illuminated (or any illumination processing operation).

Referring to FIG. 4, the tissue fluorescent positioning image and illumination processing system of another preferred embodiment of the present invention includes a blood vessel thermal coagulation device, and the blood vessel thermal coagulation device is marked according to the fluorescent image of the image to be processed. Moving to the position to be treated to perform a vascular thermal coagulation operation at the position to be treated. When the light irradiation device [optical fiber laser or LED laser] 10a is irradiated onto the predetermined tissue region, the image to be processed is taken by the photographing device 11a.

Referring to FIG. 4, for example, the vascular thermal coagulation device is coupled to the illumination handheld device 1B via the bottom opening 13, and the vascular thermal coagulation device extends through the side operation window 12 to perform a A series of tissues [various tumors, arteries, veins or blood vessels] are used to locate vascular thermal coagulation operations. In addition, the vascular thermal coagulation device is selected from a laser photothermal device (optical fiber laser), an ultrasonic thermal device, a radio frequency thermal device or an electrode thermal device.

Figure 5 is a schematic diagram showing the use of a light illumination device for the tissue fluorescence localization image and illumination processing system of the preferred embodiment of the present invention. Referring to FIG. 5, the tissue fluoroscopic image and illumination processing system of the preferred embodiment of the present invention selectively integrates the light illuminating device 10a and the photographic device 11a on the illuminating handheld device 1B to form an illuminating camera. Integration module.

Figure 6 is a schematic view showing another embodiment of the light-emitting positioning image and illumination processing system of the preferred embodiment of the present invention. Referring to FIG. 5, the tissue fluorescent positioning image and illumination processing system of the preferred embodiment of the present invention selects a different wavelength light illumination module 10b, a white light illumination module 10c, and a photography module (or a lens module). The group 11b is appropriately integrated and connected to a light-handheld device 1C for convenient use and operation.

Referring to FIG. 6 again, for example, the different wavelength light illumination module 10b includes a plurality of laser beams of different wavelengths, a plurality of LED lamps of different wavelengths, or a plurality of fiber groups of different wavelengths, so that The white light illumination module 10c includes a single or a plurality of white LED light groups or fiber groups, and the camera module 11b can be selected from a photographic lens or an infrared photographic lens.

Referring to FIG. 6 again, for example, a plurality of laser light groups of the different wavelength light irradiation module 10b, a plurality of LED lamps of different wavelengths, or a plurality of fiber groups of different wavelengths are arranged around the camera. A plurality of white LED lamp groups or fiber groups of the white light illumination module 10c are disposed around the different wavelengths of the light irradiation module 10b.

The foregoing preferred embodiments are merely illustrative of the present invention and its technical features, and the technology of the embodiments can be implemented by various substantial equivalent modifications and/or alternatives; therefore, the scope of the present invention is subject to the appended patent application. The scope defined by the scope shall prevail. The copyright limitation of this case is used for the purpose of patent application in the Republic of China.

Claims (10)

A tissue fluorescence localization image and illumination processing system comprising: at least one indicator fluorescent substance pre-injected into a predetermined tissue area in a suitable manner; a light control host that emits at least one automatic control command; at least one a light irradiation device connected to the illumination control host by wire or wirelessly, and the light illumination device is irradiated to the predetermined tissue region by a first predetermined wavelength light, so as to use the fluorescent display of the indicator fluorescent substance, Searching and indicating a position to be illuminated, wherein the position to be illuminated is located in the predetermined tissue area, and the indicator fluorescent substance can flow to the predetermined tissue area; at least one photographing device that connects the communication by wire or wirelessly Controlling the host, and the photographing device is configured to photograph the position to be illuminated to output a to-be-processed image; and at least one display device is connected to the illumination control host by wire or wirelessly, so as to The photographing device appropriately receives the image of the to-be-processed position, and displays the image of the to-be-processed position on the display The light illuminating device and the photographic device are disposed on an illumination handheld device, so that when the light illuminating device of the illuminating handheld device illuminates the predetermined tissue region, the photographic device of the illuminating handheld device takes the to-be-processed position And illuminating, by the light illumination device of the illumination handheld device, a second predetermined wavelength light or the first predetermined wavelength light is irradiated to the to-be-illuminated processing position with a predetermined power light according to the image to be processed. A tissue fluorescence localization image and illumination processing system comprising: at least one indicator fluorescent substance pre-injected into a predetermined tissue area in a suitable manner; a light control host that emits at least one automatic control command; at least one a light illumination device connected to the illumination control host by wire or wirelessly, and the light illumination device is irradiated to the predetermined tissue region with a first predetermined wavelength of light to utilize the fluorescent material of the indicator fluorescent substance Displaying, searching and indicating a position to be illuminated, wherein the position to be illuminated is located in the predetermined tissue area, and the indicator fluorescent substance can flow to the predetermined tissue area; at least one photographing device, which is wired or wireless Connecting to the illumination control host, and the photographing device is configured to photograph the to-be-processed position to output a to-be-processed position image; and at least one display device is connected to the illumination control host by wire or wirelessly, so that Receiving, by the photographing device, the image of the to-be-processed position, and displaying the image of the to-be-processed position on the display device; wherein the light-irradiating device and the photographing device are disposed on an endoscope device to be in the endoscope device When the light irradiation device is irradiated to the predetermined tissue region, the image of the image to be processed is taken by the image capturing device of the endoscope device, and the light irradiation device of the image device is switched to use a second image according to the image of the image to be processed. The predetermined wavelength light or the first predetermined wavelength light is irradiated to the to-be-illuminated processing position with a predetermined power light. A tissue fluorescence localization image and illumination processing system comprising: at least one indicator fluorescent substance pre-injected into a predetermined tissue area in a suitable manner; a light control host that emits at least one automatic control command; at least one a light irradiation device connected to the illumination control host by wire or wirelessly, and the light illumination device is irradiated to the predetermined tissue region by a first predetermined wavelength light, so as to use the fluorescent display of the indicator fluorescent substance, Searching and indicating a position to be illuminated, wherein the position to be illuminated is located in the predetermined tissue area, and the indicator fluorescent substance can flow to the predetermined tissue area; at least one photographing device that connects the communication by wire or wirelessly Controlling the host, and the photographing device is configured to photograph the illumination to-be-processed position to output a to-be-processed location image; and at least one display device that is connected to the illumination control host by wire or wirelessly, so as to The photographing device appropriately receives the image of the to-be-processed position And displaying the image of the image to be processed on the display device; wherein when the light irradiation device is irradiated to the predetermined tissue region, the image of the image to be processed is taken by the camera device, and the image is processed according to the image to be processed The light illuminating device switches the light of a second predetermined wavelength or the first predetermined wavelength of light to the position to be illuminated by a predetermined power. The tissue fluorescence localization image and illumination processing system according to claim 1, 2 or 3, wherein the light illumination device is selected from the group consisting of an LED device, a LASER device or a fiber optic illumination device. The tissue fluorescence localization image and illumination processing system according to claim 1, 2 or 3, wherein the imaging device is selected from a digital imaging device or an infrared imaging device. The tissue fluoroscopic image and illumination processing system according to the first, second or third aspect of the patent application, wherein the photographic device further comprises an image processing unit, and the image processing unit is configured to process the image to be processed. The tissue fluoroscopic image and illumination processing system of claim 1, 2 or 3, wherein the display device comprises a computer screen display, a flat panel display, a mobile phone display, a television display, or any combination thereof. The tissue fluoroscopic image and illumination processing system of claim 1, wherein the illumination handheld device has a side operation window for the light illumination device and the photographic device to perform a light irradiation operation through the side operation window. And a photography job. The tissue fluorescence localization image and illumination processing system of claim 2, wherein the endoscope device comprises an illumination fiber or a halogen fiber. The tissue fluorescence localization image and illumination processing system according to claim 2, wherein the endoscope device is selected from the group consisting of a cystoscope, a intestinal mirror, a gastroscope, a colonoscopy, a bronchoscope, and a laparoscopic mirror. Or a capsule endoscope.