TWM559175U - Acacia gerberate capsule structure - Google Patents

Abstract

The present invention relates to a compound of acacia geranyl ester capsule, which comprises a capsule body, the capsule body having a sustained release film layer, and an inner space of the sustained release film layer is disposed in the accommodating space. There is an appropriate amount of acacia geranyl ester mixed structure, wherein the acacia geranyl ester mixed structure, the main component comprises pentagenyl ester (Gefarnate), combined with a sustained release film made of a sustained release film layer seal, to achieve convenient carrying and stomach Mucosal protection and ulcer healing for clinical purposes.

Description

Acacia geranyl ester capsule structure

The present invention is a compound of acacia geranyl ester capsule, especially a kind of acacia geranyl ester capsule product which has the advantages and functions of carrying and taking, and is specially combined with the film coating technology to form acacia fragrant leaves with gastric mucosal protection and ulcer healing effect. Formulated with an ester capsule and easily absorbed.

Chronic gastritis refers to chronic inflammatory lesions of gastric mucosa caused by various causes, most of which are gastric antrum-based gastritis. The gastric mucosa is mainly infiltrated by lymphocytes and plasma cells. Some patients may have gastric glandular glandular atrophy in the later stage. . Gastritis often recurs, with a good onset in middle age and above, and a tendency to increase with age. The main causes of chronic gastritis include Helicobacter pylori infection and immune factors. Duodenal juice and bile reflux are common physical and chemical factors, and some factors may have additive or synergistic damage. Most patients with chronic gastritis have no obvious symptoms, or have different degrees of dyspepsia, such as upper abdominal discomfort after eating, fullness, irregular abdominal pain, acid reflux, belching, burning sensation, loss of appetite, nausea, Vomiting and so on. A small number of people with gastric mucosal erosion have upper gastrointestinal bleeding, although usually a small amount of bleeding. Chronic gastritis has fewer gastrointestinal symptoms and can cause significant anorexia, weight loss, and anemia. Most of the chronic gastritis has no obvious signs, and sometimes there may be mild tenderness in the upper abdomen. There are many drugs in the gastrointestinal tract. In particular, the use of lozenges, liquids, and injections is particularly common in conventional techniques for use efficiency and efficacy. The use of the injection mainly improves the absorption efficiency and solves the problem that the absorption efficiency of the tablet and the liquid agent is not good. With the increasing demand for efficacy, taste, smell and quality of modern people's functional health care products or health foods or medicines, in order to have a place in the existing market, each functional health care product or health food or pharmaceutical industry is Continuously research and develop new products to meet the market demand of modern people seeking new changes, and thus achieve the effect of enhancing market competitiveness; the reason is that the creators have in view of the needs of existing functional health products or health foods or medicines, and The method of taking, absorbing, odor avoiding, diversifying efficacy and carrying convenience solves the problem, creating a compound of acacia geranyl ester capsule for gastric mucosal protection and ulcer healing, providing a convenient and convenient for taking and carrying The ulcer and the protective acacia geranyl ester capsule structure greatly create and enhance the field of use and function, and subvert the limitations of conventional techniques on functional products for the gastrointestinal tract. The present invention provides a soft capsule of acacia geranyl ester capsule structure for gastric mucosal protection and ulcer healing. It is a new dosage form developed after tablets and injections, and the outer shell is made of gelatin, and the capsule is filled with liquid. Liquid medicine. It is characterized by slower onset than injections, but it works faster than tablets, capsules and granules. It has high bioavailability, is convenient to carry than oral liquid, and can be changed slightly on the capsule shell to make a sustained release dosage form such as enteric soft capsules, and can also be used as a suppository. Because soft capsules have the precise content, scientific process, convenient use, high bioavailability, fast onset and high curative effect that other dosage forms do not have. It is increasingly favored by the market and patients.

This creation is about a compound of Acacia fragrans capsule for gastric mucosal protection and ulcer healing. The first feature of this creation is that clinical studies have confirmed that the Acacia geranium capsule structure has It can increase the blood flow and mucus secretion of the digestive tract mucosa, and increase the thickness of the mucus layer to enhance the resistance of the tissue. It can also enhance the action of the gastric mucus barrier (GASTRIC MUCOUS BARRIER) and strengthen the mucosal tissue. The second characteristic of this creation is that clinical studies have confirmed that the structure of the acacia geranyl ester capsule has the tissue metabolism of the activated ulcer part, increases the tissue repair ability, promotes the regeneration and function recovery of the epithelial cells, and cures the damaged mucosa tissue. The third characteristic of this creation is that clinical studies have confirmed that the structure of the acacia geranyl ester capsule can enhance the resistance of the mucosal tissue and inhibit the recurrence of the ulcer. The fourth characteristic of this creation is that the structure of the acacia geranyl ester capsule can resist the release of the contents from the acid environment to the intestine, increase the efficiency of mucosal absorption, and rapidly exert pharmacological effects. The fifth feature of the creation is the acacia geranyl ester capsule structure, which has the advantages of convenient consumption by the user and convenience of carrying. The present invention relates to a compound of acacia geranyl ester capsule for gastric mucosal protection and ulcer healing, comprising: a capsule body having a sustained release film layer, wherein the sustained release film layer is internally provided with a capsule body The accommodating space has an appropriate amount of acacia sinensis mixed structure in the accommodating space, wherein the sustained-release film layer seals the acacia sinensis mixed structure into the accommodating space.

Preferably, the acacia sinensis mixed structure has an appearance selected from the group consisting of a gel, a particle suspension, a homogeneous liquid, and an emulsion, and the capsule body is a capsule having liquid adhesion. body.

Preferably, the acacia sinensis mixed structure has an appearance selected from a combination of a group consisting of a powder, a sheet, an envelope, and an adherent, and the capsule body is a capsule body having a solid adhesion. .

Preferably, the acacia geranyl ester mixed structure system is achieved by mixing acacia geranyl ester with an auxiliary material selected from the group consisting of vegetable oils, aromatic hydrocarbon esters, organic acids, glycerin, and isopropyl alcohol. Propylene glycol, polyethylene glycol (PEG), polyethylene glycol 400, fatty acid glycerides, intermediate fatty acid glycerides, surfactants, Tween-80 and its constituents.

Preferably, the sustained-release film layer and the accommodating space further comprise a protective casing formed by a first butt joint and a second casing, and the protective casing can cushion the seal. Accommodate space.

Preferably, the sustained release film layer is achieved by a group selected from the group consisting of a film sealing method, an infiltration drying method, a coating precipitation method, and a combination thereof.

Preferably, the sustained release film layer is passed through a group selected from the group consisting of thick bovine gelatin film, bovine gelatin film, fish gelatin film, pig gelatin film, poultry gelatin film, carrageenan seaweed extract film, non-gelatin film and combinations thereof. To reach. More preferably, the sustained release film layer is achieved by a population selected from the group consisting of a carrageenan extract film, a non-gelatin film, and combinations thereof.

Preferably, the sustained release film layer has a shape selected from the group consisting of a circle, an ellipse, a fish, a tube, and a combination thereof.

The present invention provides a compound of acacia geranyl ester capsule for gastric mucosal protection and ulcer healing, comprising a capsule body having a receiving space; and an inner space of the container, having an appropriate amount of acacia geranium mixed structure And using a combined change in the percentage of the mass of the substance contained in the functional acacia geranium-mixed structure to be suitable for use in pharmaceuticals or health foods or health care products. Because of the functional design of the gastrointestinal physiology improvement, gastric mucosal protection and ulcer healing function, the functional acacia geranyl ester mixed structure is packaged in a capsule body, so that only one capsule body can achieve the desired functional effect at the same time. It has the advantages of being easy to carry and take and more effective.

1,1’‧‧‧ capsule body

3,3'‧‧‧Acacia geranyl ester mixed structure

11‧‧‧First housing

12‧‧‧ second housing

13,13’‧‧‧ accommodating space

15,15'‧‧‧ sustained release film

Fig. 1 is a schematic view showing the structure of acacia geranyl ester capsule of the first embodiment of the present invention.

Fig. 2 is a schematic view showing the structure of acacia geranyl ester capsule of the second embodiment of the present invention.

In order to make the above and other objects, features and advantages of the present invention more comprehensible, the preferred embodiments of the present invention are described in detail below with reference to the accompanying drawings.

First Embodiment: Acacia geranyl ester capsule structure

The present invention provides a first embodiment of a eucalyptus gum capsule structure for gastric mucosal protection and ulcer healing. As shown in FIG. 1, the content comprises a capsule body 1 which is composed of a first housing 11 and a second The housings 12 are integrally butt-joined together, and an accommodating space 13 is formed in the first housing 11 and the second housing 12, and an appropriate amount of acacia sinensis mixed structure is disposed in the accommodating space 13. Body 3, wherein: the capsule body 1 is made of an edible grade of a gelatinous raw material; the acacia geranyl ester mixed structure 3 is mainly a mixed structure mainly composed of acacia geranyl ester, and the main component of acacia geranyl ester is A pentaester (Gefarnate), the official name of IUPAC [(2E)-3,7-dimethylocta-2,6-dienyl](4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoate. The functional Acacia geranyl ester capsule structure can be obtained through the technology and design of the present invention, and has the effect of being directly edible to improve absorption and convenience. The artificial acacia geranyl ester mixed structure preferably needs to be dissolved or mixed with a suitable liquid auxiliary material, and the commonly used auxiliary materials are vegetable oil, aromatic hydrocarbon ester, organic acid, glycerin, Isopropyl alcohol, propylene glycol, polyethylene glycol (PEG) 400, intermediate fatty acid glycerides, surfactants and Tween-80. A soft capsule is prepared by adding a surfactant or other absorption enhancer, wherein the drug is dispersed in the molecular state in the oil, and the oil phase spontaneously forms an emulsion in the oil phase due to the action of the surfactant, and enters the blood through the lymph. The effects of over-effects result in higher bioavailability. Preferably, the capsule body is further externally coated with a sustained release film layer 15, and specifically, the sustained release film layer 15 is achieved by a film sealing method or a wet drying method or a coating precipitation method. More preferably, the creation uses a thick cow gelatin film, which can be completely hermetically sealed, the capsule strength and the film are highly segmented, and the content can be kept stable for a long time. The gelatin film of the present invention is more than 30 times more than the polyethylene film. It is very stable to oxygen in the air and can prevent oxidation and moisture absorption of the air. The thick cow gelatin film can also provide a suitable choice for consumers who are considering the source of pig raw materials. Alternatively, it can also be selected from thick cow gelatin film and bovine gelatin film. , fish gelatin film, pig gelatin film, poultry gelatin film, carrageenan seaweed extract film, non-gelatin film and its combination of ethnic groups.

Second Embodiment: Acacia geranyl ester capsule structure

The present invention provides a second embodiment of a cedar geranyl ester capsule structure for gastric mucosal protection and ulcer healing, and provides a soft capsule structure of acacia geranyl ester for gastric mucosal protection and ulcer healing, as shown in FIG. 2, The content includes a capsule body 1' having a sustained release film layer 15'. The inside of the sustained release film layer 15' is provided with an accommodating space 13', and the accommodating space 13' is provided in the accommodating space 13'. An appropriate amount of acacia geranyl ester mixed structure 3', wherein: the capsule body 1' is made of an edible grade of a gelatinous raw material; the acacia geranyl ester mixed structure 3' is mainly a main mixed structure, the main The ingredient, acacia geranyl ester, is a pentaenyl ester (Gefarnate), the official name of IUPAC [(2E)-3,7-dimethylocta-2,6-dienyl] (4E, 8E)-5,9,13-trimethyltetradeca-4,8,12-trienoate. The functional Acacia geranyl ester capsule structure can be obtained through the technology and design of the present invention, and has the effect of being directly edible to improve absorption and convenience. The sustained release film layer 15' is obtained by a film sealing method, a wet drying method or a coating precipitation method, and preferably has a diameter of less than 1 cm. The functional Acacia geranyl ester capsule structure can be obtained through the technology and design of the present invention, and has the effect of being directly edible to improve absorption and convenience. Preferably, the acacia geranyl ester mixed structure needs to be dissolved or mixed with a suitable liquid auxiliary material, and the commonly used auxiliary materials are vegetable oil, aromatic hydrocarbon ester, organic acid, glycerin, isopropanol, propylene glycol, polyethylene glycol (PEG) 400, Intermediate fatty acid glycerol ester, surfactant and Tween-80. A soft capsule is prepared by adding a surfactant or other absorption enhancer, wherein the drug is dispersed in the molecular state in the oil, and the oil phase spontaneously forms an emulsion in the oil phase due to the action of the surfactant, and enters the blood through the lymph. The effects of over-effects result in higher bioavailability. Specifically, the capsule body 1' of the sustained release film layer 15' is achieved by a film sealing method or a wet drying method or a coating precipitation method. More preferably, the capsule body 1' of the sustained release film layer 15' is selected from a Soft Gel Capsule coating system, specifically using a thick gelatin gel film, which can be completely hermetically sealed, and the capsule strength and film coverage. The segmentation is high, and the content can be kept stable for a long time. The gelatin film of the present invention has more than 30 times of oxygen shielding than the polyethylene film, and is very stable to oxygen in the air, and can prevent oxidation and moisture absorption of the air, and the thick cow gelatin film is also selected. It can provide a suitable choice for consumers considering the source of raw materials for pigs. Alternatively, it can be selected from thick beef gelatin film, bovine gelatin film, fish gelatin film, pig gelatin film, poultry gelatin film, carrageenan seaweed extract film, non-gelatin film. And the group formed by its combination.

Optionally, the present invention provides a soft-capsule structure of acacia sinensis for gastric mucosal protection and ulcer healing, which is coated with acacia sinensis by soft capsule or soft gel forming technique. In this embodiment, the acacia geranyl ester is mainly dispersed in an oil or a water-insoluble liquid or suspension which does not dissolve the gelatin, and is further enclosed in a capsule shell, and has a circular shape. , oval, fish, tube, etc. Soft capsules are a new type of preparation developed after tablets and injections. The outer shell is made of gelatin, and the capsule is filled with liquid medicine. It is characterized by slower onset than injections, but it works faster than tablets, capsules and granules. It has high bioavailability, is convenient to carry than oral liquid, and can be changed slightly on the capsule shell to make a sustained release dosage form such as enteric soft capsules, and can also be used as a suppository. Because soft capsules have the precise content, scientific process, convenient use, high bioavailability, fast onset and high curative effect that other dosage forms do not have. It is increasingly favored by the market and patients. This creation can disperse the carnation geranyl ester in liquid oily substance and directly enclose it in the capsule, without using additives such as adsorption and inclusion, and the oil content of the soft capsule of the present invention is as high as 60% to 85% by weight, and The content of the package is generally less than 50%.

The present invention provides a structure of acacia geranyl ester capsule for gastric mucosal protection and ulcer healing, which has the characteristics of high stability: the creation of a compound of acacia geranyl ester capsule for gastric mucosal protection and ulcer healing is combined with soft capsules. The structure is shaded and oxidized to reduce the chance of the active ingredient coming into contact with light or air. Alternatively, if a thick gelatin film is used, it can be completely hermetically sealed, and the capsule strength and film barrier property are high, and the contents can be kept stable for a long period of time. The gelatin film has an oxygen barrier property of more than 30 times that of the polyethylene film. It is very stable to oxygen in the air, prevents oxidation and moisture absorption of the air, and has high stability. The present invention provides a compound of acacia sinensis ester capsule for gastric mucosal protection and ulcer healing. The scented leaf ester capsule structure has the characteristics of precise dosage: the high-accuracy precision instrument is used to uniformly and completely inject the active ingredient into the soft rubber. To make the amount accurate. The present invention provides a compound of acacia geranyl ester capsule for gastric mucosal protection and ulcer healing. The fragrant leaf ester capsule structure has good absorption characteristics: higher absorption than traditional tablets or hard capsules, and also better than tablets. gum The granules and granules act quickly, and are easily dissolved in the pH of the gastric juice, so that the drug is released quickly, so the human body can be more effectively utilized. Therefore, the present invention can provide a higher total bioavailability (AUC), a faster rate of absorption (tmax), and a higher blood level (Cmax).

The present invention provides a special feature of acacia geranyl ester capsule structure for gastric mucosal protection and ulcer healing: 1. Easy to swallow: gelatin of the soft capsule itself dissolves due to water, and can produce a slippery sensation, so it is easy to swallow. 2. The color and flavor are both convenient and convenient: the taste, color, fragrance, transparency and gloss of the soft capsule film can be freely selected. Compared with other round products, the appearance is lustrous and eye-catching. Moreover, it is convenient for the user to take and easy to carry, so the degree of acceptance is high. 3. It can cover certain contents of odor, odor, and does not easily leave odor in the mouth like a tablet. 4. It is not necessary to add additives such as binders and molding agents. Generally, soft capsules are made of gelatin, glycerin and water, and are edible natural products. 5. A round-type airtight container is a purifying type container when foreign matter cannot be mixed in during circulation. 6. For low boiling points, volatile substances such as acacia sinensis can be stably stored. Moreover, some of the contraindication ingredients can be separately added to the two-layer content.

Optionally, the present invention provides a carrageenan seaweed extraction soft capsule prepared by using a non-gelatin film, a carrageenan seaweed extract film and a combination thereof for a gastric mucosal protection and ulcer healing. Stabilize the content of the ingredients by strengthening the gelatin capsules. Optionally, the creation is more distinctive and conforms to a specific target group: 1. suitable for vegetarians and ordinary people; 2. no animal raw materials 3. strong and brittle characteristics can protect the content of acacia geranyl ester; 4. No genetically modified biological materials. The specific carrageenan seaweed extract soft capsule is Vegesoft vegetarian soft gel capsule.

The creator of this case is engaged in the development of biotech medical beauty care related products and biomedical engineering materials. With such rich experience, in view of this, the creators of this case, based on their years of research and development experience in related fields, conducted in-depth discussions on the aforementioned shortcomings, and actively sought solutions based on the above-mentioned needs, after long-term efforts and multiple tests. And finally completed this creation. Although the present invention has been disclosed by the above-described preferred embodiments, it is not intended to limit the present invention, and it is still within the spirit and scope of the present invention to make various changes and modifications to the above embodiments. The technical scope of the protection is created, so the scope of protection of this creation is subject to the definition of the patent application scope attached.

Claims (9)

A comfrey geranyl ester capsule structure comprising: a capsule body having a sustained release film layer, wherein the sustained release film layer is provided with an accommodating space therein, and an appropriate amount is disposed in the accommodating space A compound of acacia geranium ester, wherein the sustained release film layer seals the mixed structure of acacia sinensis into the accommodating space. The acacia geranyl ester capsule structure according to claim 1, wherein the acacia geranyl ester mixed structure has a appearance selected from the group consisting of a gel, a particle suspension, a homogeneous liquid, and an emulsion. And the capsule body is a capsule body having liquid adhesion. The acacia geranyl ester capsule structure according to claim 1, wherein the acacia geranyl ester mixed structure has an appearance selected from the group consisting of powders, sheets, coatings, and adherends. And the capsule body is a capsule body having a solid adhesion. The acacia geranyl ester capsule structure according to claim 1, wherein the acacia geranyl ester mixed structure system is obtained by mixing acacia geranyl ester with an auxiliary material selected from the group consisting of vegetable oil and aromatic hydrocarbon ester. , organic acids, glycerol, isopropanol, propylene glycol, polyethylene glycol (PEG), polyethylene glycol 400, fatty acid glycerides, intermediate fatty acid glycerides, surfactants, Tween-80 and its constituents . The acacia geranium capsule structure according to claim 1, wherein the sustained release film layer and the accommodating space further comprise a protective casing through a first casing and a second The housing is formed by a common butt joint, and the protective housing can buffer and seal the accommodating space. The acacia geranol capsule structure according to claim 1, wherein the sustained release film layer is obtained by a group selected from the group consisting of a film sealing method, an infiltration drying method, a coating method, and a combination thereof. The acacia geranol capsule structure according to claim 1, wherein the sustained release film layer is selected from the group consisting of thick cow gelatin film, bovine gelatin film, fish gelatin film, pig gelatin film, poultry gelatin film, A group consisting of carrageenan seaweed extract membrane, non-gelatin membrane and combinations thereof. The acacia sulphate capsule structure according to claim 1, wherein the sustained release film layer has a shape selected from the group consisting of a circle, an ellipse, a fish, a tube, and a combination thereof. The acacia sulphate capsule structure according to claim 7, wherein the sustained release film layer is obtained by a group selected from the group consisting of carrageenan seaweed extract film, non-gelatin film and combinations thereof.