TWM532565U - Biological test chip - Google Patents

Description

Biological test strip

The present invention relates to a test strip, and more particularly to a bioassay strip.

Although medical progress has made people's lifespan much longer than before, chronic diseases have gradually replaced infectious diseases and become one of the main causes of human death. Therefore, by detecting blood sugar, cholesterol, uric acid and other values in the human body, further To determine whether a organism has a potential chronic disease, in addition to protein, DNA, etc., it can be applied to the detection of various biological values.

The common home-type testing tools can be mainly divided into a testing machine and a test piece for testing by the testing machine. After the test substance is in contact with the test piece, the testing machine can perform rapid detection, and common testing pieces such as the United States. The "Electrode strip and sensor strip and manufacture method thereof and system thereof" includes a first substrate, a first electrode group disposed on the first substrate, and a first electrode group disposed on the first electrode group. An insulating layer, a second substrate disposed on the first insulating layer, a second electrode group disposed on the second substrate, and a second insulating layer disposed on the second electrode group, the first insulating layer comprising a first recess, the second substrate includes a sampling port and a hole, wherein the sampling port is disposed at an outer edge of the second substrate, the hole is disposed inside the second substrate, and the second electrode group is not formed The second insulating layer includes a second recess, wherein the hole vertically communicates with the first recess and the second recess.

Wherein, the material of the first electrode group and the second electrode group is gold glue, and is made by screen printing, however, it is well known that the price of gold is relatively expensive. When printing, a large amount of gold glue will remain on the screen, which will lead to an increase in cost, and screen printing is prone to the problem of plugging, resulting in uneven thickness. In addition, each batch of printed substrates is baked. At the same time, the baking temperature will be different, which will affect the crystallization effect of gold, resulting in different electrical resistance and affecting the accuracy of the measurement. Therefore, how to reduce the cost, accurately control the thickness of the gold layer and improve the accuracy of the measurement is a major issue.

The main purpose of the novel is to solve the problem that the method of forming an electrode by screen printing is costly, the thickness of the gold layer cannot be accurately controlled, and the measurement accuracy is low.

In order to achieve the above object, the present invention provides a bio-detection test piece comprising a substrate, an electrode, a first nickel layer, and a first gold layer, the substrate comprising a detecting portion and a measuring portion, wherein the electrode is disposed on the substrate On the substrate, and including a working electrode, a reference electrode and an auxiliary electrode, the working electrode has a first working end located at the detecting portion and a first reading end located at the measuring portion, the first nickel layer The first gold layer is formed on the side of the first working end away from the substrate, and the first gold layer is formed by the nickel immersion gold on the side of the first nickel layer away from the substrate.

In summary, the new method utilizes nickel immersion gold to form gold on the first nickel layer while the first nickel layer emits electrons, thereby reducing gold waste and reducing cost. The thickness of the first gold layer is precisely controlled, and in addition, the step of baking is not required, and the electric resistance can be made uniform, and the accuracy of the measurement can be improved.

The detailed description and technical content of this new model are described below with the following diagram:

Referring to FIG. 1 and FIG. 2, the present invention is a bioassay test piece comprising a substrate 10, an electrode 20, a first nickel layer 31, and a first gold layer 41. The substrate 10 includes A detecting portion 11 and a measuring portion 12 are disposed on the substrate 10 and include a working electrode 21, a reference electrode 22 and an auxiliary electrode 23. The working electrode 21 has a detecting portion 11 a first working end 211 and a first reading end 212 of the measuring portion 12, the reference electrode 22 has a second working end 221 at the detecting portion 11 and a second reading at the measuring portion 12. The auxiliary electrode 23 has a third working end 231 located at the detecting portion 11 and a third reading end 232 located at the measuring portion 12, and the first nickel layer 31 is formed in the first working The end 211 is away from one side of the substrate 10, and the first gold layer 41 is formed on the side of the first nickel layer 31 away from the substrate 10 by means of immersion gold. The material of the electrode 20 is copper, and the thickness of the first gold layer 41 is 3 microinches (μin) or more. In this way, by using nickel immersion gold, the waste of gold can be reduced, the cost can be reduced, and the thickness of the first gold layer 41 can be precisely controlled without baking, and the resistance can be made uniform, and the measurement can be improved. Accuracy.

In this embodiment, a second nickel layer 32, a second gold layer 42, a second conductive layer 52, a third nickel layer 33, a third gold layer 43, and a third conductive layer 53 are further included. The second nickel layer 32, the second gold layer 42 and the second conductive layer 52 are sequentially disposed on a side of the second working end 221 away from the substrate 10, the third nickel layer 33, the third The gold layer 43 and the third conductive layer 53 are sequentially disposed on a side of the third working end 231 away from the substrate 10, and if the cost is further reduced, the second nickel layer 32, the second gold layer 42, The third nickel layer 33 and the third gold layer 43 may be omitted, and the second conductive layer 52 and the first portion are formed directly from the second working end 221 and the third working end 231 away from the substrate 10 Three conductive layers 53. The material of the second conductive layer 52 may be silver, silver chloride or a combination thereof, and the material of the third conductive layer 53 may be carbon, platinum or a combination thereof.

In addition, the present embodiment further provides an insulating layer 60 disposed on the substrate 10 adjacent to the electrode 20, and the electrode 20, the first nickel layer 31, and the first gold layer 41. The peripheral contact contacts and covers the periphery of the first gold layer 41 away from the side of the first nickel layer 31. Thus, the exposure of the first nickel layer 31 and the electrode 20 can be prevented, thereby affecting the accuracy of measurement. .

Continued collocation Referring to "FIG. 3A" to "FIG. 3F", the manufacturing process of the present invention is clearly indicated by the AA cross-section of FIG. 1 as shown in FIG. 3A before the substrate 10 The electrode 20 is formed thereon. Then, as shown in FIG. 3B, a lower insulating portion 61 of the insulating layer 60 may be formed adjacent to the electrode 20 on the substrate 10, and then, as shown in FIG. 3C, Forming the first nickel layer 31, the second nickel layer 32, and the third nickel layer 33 on the first working end 211, the second working end 221, and the third working end 231, respectively, as shown in FIG. 3D The first gold layer 41, the second gold layer 42, and the third gold layer 43 are formed on the first nickel layer 31 and the second nickel layer 32 by means of nickel immersion gold. Above the third nickel layer 33. The nickel immersion gold is immersed in a low concentration gold solution, and gold is deposited thereon while the first nickel layer 31, the second nickel layer 32, and the third nickel layer 33 are ejected with electrons.

Continuing to refer to FIG. 3E, the second conductive layer 52 is formed on a side of the second gold layer 42 away from the substrate 10, and the third conductive layer 52 is formed on a side of the third gold layer 43 away from the substrate 10. The conductive layer 53 and finally, as shown in FIG. 3F, an insulating portion 62 of the insulating layer 60 is formed on the lower insulating portion 61, and the insulating layer 60 and the electrode 20, the first nickel layer 31, and The periphery of the first gold layer 41 contacts and covers the periphery of the first gold layer 41 away from the side of the first nickel layer 31. In this embodiment, the insulating layer 60 also covers the periphery of the second conductive layer 52 and the third conductive layer 53 away from the side of the substrate 10. Further, the insulating layer 60 may be directly formed without separately forming the lower insulating portion 61 and the upper insulating portion 62.

In summary, the new model has the following characteristics:

1. By using nickel immersion gold, the waste of gold can be reduced to reduce the cost, and the thickness of the first gold layer can be precisely controlled without baking, and the resistance can be made uniform, and the measurement can be improved. Accuracy.

2. The arrangement of the insulating layer prevents the first nickel layer and the electrode from being exposed, thereby affecting the accuracy of the measurement.

Therefore, this new type is highly progressive and meets the requirements for applying for a new type of patent. It is required to apply in accordance with the law, and the Bureau of Health will grant patents as soon as possible.

The present invention has been described in detail above, but the above is only a preferred embodiment of the present invention, and the scope of the present invention is not limited. That is, the equal changes and modifications made in accordance with the scope of this new application shall remain within the scope of the patent of this new type.

10‧‧‧Substrate
11‧‧‧Detection Department
12‧‧‧Measurement Department
20‧‧‧ electrodes
21‧‧‧Working electrode
211‧‧‧ first working end
212‧‧‧First reading end
22‧‧‧ reference electrode
221‧‧‧Second working end
222‧‧‧second reading end
23‧‧‧Auxiliary electrode
231‧‧‧ Third working end
232‧‧‧ third read end
31‧‧‧First nickel layer
32‧‧‧Second nickel layer
33‧‧‧ Third nickel layer
41‧‧‧First gold layer
42‧‧‧Second gold layer
43‧‧‧ third gold layer
52‧‧‧Second conductive layer
53‧‧‧ Third conductive layer
60‧‧‧Insulation
61‧‧‧ Lower insulation
62‧‧‧Upper insulation

FIG. 1 is a schematic perspective view of a preferred embodiment of the present invention. Figure 2 is a cross-sectional view taken along line A-A of Figure 1. 3A-3F are schematic views showing the manufacturing process of a preferred embodiment of the present invention.

10‧‧‧Substrate

11‧‧‧Detection Department

12‧‧‧Measurement Department

20‧‧‧ electrodes

21‧‧‧Working electrode

211‧‧‧ first working end

212‧‧‧First reading end

22‧‧‧ reference electrode

221‧‧‧Second working end

222‧‧‧second reading end

23‧‧‧Auxiliary electrode

231‧‧‧ Third working end

232‧‧‧ third read end

41‧‧‧First gold layer

52‧‧‧Second conductive layer

53‧‧‧ Third conductive layer

60‧‧‧Insulation

Claims (10)

A bio-detection test piece comprising: a substrate comprising a detecting portion and a measuring portion; an electrode disposed on the substrate, comprising a working electrode, a reference electrode and an auxiliary electrode, the working electrode having a a first working end of the detecting portion and a first reading end of the measuring portion; a first nickel layer formed on a side of the first working end away from the substrate; and a nickel immersion gold The method is formed on the first gold layer of the first nickel layer away from one side of the substrate. The bioassay test piece according to claim 1, wherein the first gold layer has a thickness of 3 micro inches or more. The biological test strip of claim 1, wherein the reference electrode has a second working end located at the detecting portion and a second reading end located at the measuring portion, the second working end being away from One side of the substrate has a second conductive layer. The biological test strip of claim 1, wherein the reference electrode has a second working end located at the detecting portion and a second reading end located at the measuring portion, the second working end being away from A second nickel layer, a second gold layer and a second conductive layer are disposed on one side of the substrate. The biological test strip according to claim 3, wherein the material of the second conductive layer is selected from the group consisting of silver and silver chloride. The biological test strip according to claim 1, wherein the auxiliary electrode has a third working end located at the detecting portion and a third reading end located at the measuring portion, the third working end being far away One side of the substrate has a third conductive layer. The biological test strip according to claim 1, wherein the auxiliary electrode has a third working end located at the detecting portion and a third reading end located at the measuring portion, the third working end being far away A third nickel layer, a third gold layer and a third conductive layer are sequentially disposed on one side of the substrate. The biological test strip according to claim 6 or 7, wherein the material of the third conductive layer is selected from the group consisting of carbon and platinum. The bioassay test piece according to claim 1, wherein the electrode is made of copper. The biological test strip according to claim 1, further comprising an insulating layer disposed on the substrate adjacent to the electrode, the insulating layer and the electrode, the first nickel layer and the first gold layer The peripheral contact contacts and covers the periphery of the first gold layer away from one side of the first nickel layer.