TWM508530U - Holder for dialysis bag - Google Patents

Description

Dialysis bag holder

The present invention is mainly concerned with a dialysis bag fixing member for fixing the dialysis bag in the dialysis tank and completely immersing it in the dialysate to improve the dialysis efficiency.

Dialysis is a separation and purification method commonly used in the fields of biochemistry and medicine. It utilizes the permeability difference of semipermeable membranes for macromolecules and small molecular substances, and allows small molecules to diffuse out of the membrane. The macromolecular material is left in the membrane, so a semipermeable membrane having a suitable pore size is selected for the purpose of separation and purification.

As shown in Fig. 4, when performing the dialysis technique, the liquid or colloidal substance to be dialyzed is generally placed in a dialysis bag 91 made of a semipermeable membrane, the bag mouth is sealed, and the dialysis bag is placed. The dialysis tank 92 is introduced and immersed in a large amount of dialysate 93, and is continuously agitated or a magnetic stirrer 94 and agitating magnet 95 are used to agitate the dialysate 93, and even the dialysate 93 outside the dialysis bag 91 is periodically replaced. By diffusing the substance from a high concentration to a low concentration, the small molecule is forced to diffuse through the semipermeable membrane into the dialysis solution, and the macromolecular substance is left in the dialysis bag because it cannot pass through the semipermeable membrane. After a few hours, the small molecule material is roughly in equilibrium inside and outside the dialysis bag, so the concentration in the dialysis bag is extremely low, and the macromolecular substance is relatively enriched in the dialysis bag. Compared with salt separation, ion exchange chromatography and other separation techniques that can dramatically change the environment of molecules, dialysis technology is not easy to cause bioactive macromolecular substances to be denatured, so it has been widely used in proteins, nucleic acids and polysaccharides. In the purification or desalination process of macromolecular substances.

During the process of placing the analyte to be placed in the dialysis bag, it is best not to bring in air bubbles. The general practice is to carefully concentrate the bubbles and push them toward the pockets, then seal the pockets. This necessary procedure is not only troublesome, but the process of pushing bubbles may also sacrifice some of the material to be dialyzed, which is extremely unpleasant in the high-priced medical process. What's more, even with very careful operation, air bubbles are often contained in the sealed dialysis bag, which not only reduces the surface area of the semipermeable membrane through which small molecules can diffuse, but also makes the dialysis bag not completely immersed in the dialysate. On the contrary, due to the small specific gravity of the bubble, it floats on the surface of the dialysate, thus significantly reducing the efficiency of the dialysis process.

Therefore, there is a great need in the art for a dialysis bag holder for securing a dialysis bag in a dialysis cell that is completely immersed in the dialysate to enhance dialysis efficiency.

In order to meet the needs of the industry, the creator of the case has developed a dialysis bag holder suitable for accommodating a dialysis bag in a dialysis process. The dialysis bag fixing member disclosed in the present invention comprises: a casing having a casing wall to define an interior; a main opening formed on the casing for receiving a dialysis bag and being accommodated therein; And a plurality of through holes formed on the casing such that the inside of the casing is in fluid communication with the outside.

Preferably, the dialysis bag fixing member disclosed in the present invention has a specific gravity substantially larger than the specific gravity of the dialysate, and may even be fixed in the dialysis tank, so that the dialysis bag fixing member and the dialysis bag accommodated in the fixing member can be completely immersed in the dialysate. in. Accordingly, the operator does not have to worry about whether the dialysis bag accidentally incorporates a small amount of air bubbles. Furthermore, since the housing is formed with a plurality of through holes, the dialysate can flow between the inside and the outside of the housing without any hindrance, which facilitates the diffusion of small molecular substances outside the dialysis bag, thereby achieving the purpose of dialysis separation of substances.

The characteristics of this creation can be clearly understood by referring to the detailed description of the drawings and the examples.

1 is a perspective view of a dialysis bag fixing member 1 according to a first specific example of the present invention, which includes a casing 11 having a casing wall 12 to define an interior, and the casing 11 is further formed with a main opening 14. A dialysis bag is accommodated inside the main opening 14; a plurality of through holes 15 are formed in the casing 11, so that the inside and outside of the casing 11 are in fluid communication. In general, the housing 11 is made of an inert material that does not physically and chemically react with the material to be dialyzed and the dialysate, and is preferably stable to environmental factors such as heat and pressure.

In a preferred embodiment, the housing 11 is made of medical grade plastic, more preferably a medical grade plastic that meets biocompatibility requirements, such as compliance with the US Food and Drug Administration revision. Plastic materials for the ISO-10993-1 specification (FDA-modified ISO-10993-1) or the United States Pharmacopoeia Level 6 standard (USP XXV class VI). Types of these medical grade plastics include, but are not limited to, polycarbonate (PC), polyphenylene oxide (PPO), PA6/66 nylon plastic, polycarbonate/acrylonitrile-butadiene-styrene copolymer (PC/ABS) ) Composite plastics, polyethylene terephthalate (PET), polyethyleneimine (PEI), polymethyl methacrylate (PMMA), polyphenylene sulfide (PPS), polyethylene (PE), polypropylene ( Plastic materials such as PP), polystyrene (PS), polyvinyl chloride (PVC), and ethylene/vinyl acetate copolymer (EVA). In another preferred embodiment, the housing 11 is made of a medical grade metal material, such as a medical grade stainless steel or titanium metal material. It is worth noting that the material used to make the housing 11 must have a specific gravity that is substantially greater than the specific gravity of the dialysate so that the dialysis bag holder 1 can be completely immersed in the dialysate. Since the dialysate is usually based on water, the specific gravity of the dialysis bag holder 1 is preferably substantially greater than one.

The manufacturing process of the casing 11 is familiar to those of ordinary skill in the related art, and can be adjusted depending on the material. In addition, the housing 11 can be integrally formed by a single process, or a plurality of components can be separately manufactured by a plurality of processes, and these components can be assembled into a complete casing 11. For example, when the housing 11 is made of plastic, the processes suitable for making the housing 11 include, but are not limited to, plastic molding processes such as injection molding, compression molding, and thermoforming. When the casing 11 is made of a metal material, it can be produced by a conventional metal working process such as stamping, rolling, compression molding, or forging.

The size of the housing 11 is not particularly limited as long as it is suitable for accommodating a dialysis bag. The diameter of the through hole 15 is not particularly limited as long as the inside and outside of the casing 11 are in fluid communication state, so that the dialysate can flow between the inside and the outside of the casing 11 without any hindrance, which facilitates diffusion of small molecular substances outside the dialysis bag. . The outer shape of the casing 11 is also not particularly limited. In the first specific example of the present creation, the casing 11 is formed in a cubic configuration, which makes it easy to stack and is not easily rolled in the dialysis tank.

As shown in Fig. 1, the dialysis bag holder 1 preferably further includes a cover 16 for opening or closing the main opening 14. The cover 16 can be closed to the main opening 14 by engagement with the housing 11 by any conventional engagement means such as pivoting, screwing, snapping or snapping. In this specific example, the main opening 14 is formed on one side of the cubic housing 11. The cover 16 has a first end 161 pivoted to the housing 11 and a second end 162 opposite the first end 161. The cover 16 is provided at the second end 162 with a fastener 163 for fixing the cover 16 to the housing 11 to close the main opening 14. The cover 16 can be made of any suitable material and process, but is preferably fabricated by the same materials and processes as the housing 11.

2 is a schematic cross-sectional view of the dialysis bag holder 1 according to the second specific example of the present invention, wherein the housing 11 is formed to have a cylindrical shape, and the main opening 14 is formed at one end of the cylindrical housing 11, And the casing wall 12 is provided with a thread 141 at the periphery of the main opening 14. A thread 164 corresponding to the thread 141 is provided at the outer periphery of the cover 16 such that the cover 16 can be screwed to the main opening 14 by threading the thread 141 and the thread 164.

Fig. 3 is a perspective view showing a dialysis bag fixing member according to a third specific example of the present invention, in which the through hole 15 is enlarged as much as possible so that the casing 11 assumes a configuration similar to a frame. This specific example may not be provided with a cover.

In a preferred embodiment, the dialysis bag holder 1 disclosed in the present invention is independent of the dialysis cell, is placed directly into the dialysis cell only during use, and optionally is provided with a buckle outside the casing wall 12. A piece (not shown) is fixed in the dialysis tank to prevent the dialysis bag fixing member 1 from moving in the dialysis tank, and is removed from the dialysis tank after the dialysis is completed. In another preferred embodiment, the dialysis bag holder 1 disclosed in the present invention is permanently fixed in the dialysis tank by conventional means such as welding, screwing or the like.

In the present application, the sealed dialysis bag is first placed inside the dialysis bag holder 1 via the main opening 14. When the cover 16 is provided, the cover 16 is joined to the housing 11 to close the main opening 14. Since the specific gravity of the dialysis bag fixing member 1 disclosed in the present invention is substantially larger than the specific gravity of the dialysate, and can even be fixed in the dialysis tank, the dialysis bag fixing member 1 can be completely immersed in the dialysate. Accordingly, regardless of whether or not the dialysis bag after sealing is inadvertently incorporated into the bubble, it is completely immersed in the dialysate along with the dialysis bag holder 1. Moreover, since the housing 11 is formed with a plurality of through holes 15, the dialysate can flow between the inside and the outside of the housing 11 without any hindrance, which facilitates the diffusion of small molecular substances outside the dialysis bag, thereby achieving the purpose of dialysis separation of substances. After the dialysis process is completed, the lid 16 is opened to expose the main opening 14, and the dialysis bag can be taken out and the macromolecular substance in the dialysis bag can be collected.

The technical content and technical features of the present invention have been disclosed as above, but those skilled in the art may still make various substitutions and modifications based on the disclosure of the present invention. Therefore, the scope of protection of the present invention is not limited to the embodiments disclosed, but should include various alternatives and modifications, and is covered by the following claims.

1‧‧‧dialysis bag holder
11‧‧‧Shell
12‧‧‧ shell wall
14‧‧‧ main opening
141‧‧ thread
15‧‧‧through hole
16‧‧‧ Cover
161‧‧‧ first end
162‧‧‧ second end
163‧‧‧ fasteners
164‧‧ thread
91‧‧‧dialysis bag
92‧‧‧dialysis tank
93‧‧‧ dialysate
94‧‧‧Magnetic mixer
95‧‧‧ stirring magnetic

1 is a perspective view of a dialysis bag fixing member according to a first specific example of the present creation;

2 is a schematic cross-sectional view of a dialysis bag fixing member according to a second specific example of the present creation;

Figure 3 is a perspective view of a dialysis bag fixing member according to a third specific example of the present creation;

Figure 4 is a schematic diagram showing the general mode of operation of the dialysis procedure of the prior art.

1‧‧‧dialysis bag holder

11‧‧‧Shell

12‧‧‧ shell wall

14‧‧‧ main opening

15‧‧‧through hole

16‧‧‧ Cover

161‧‧‧ first end

162‧‧‧ second end

163‧‧‧ fasteners

Claims (7)

A dialysis bag holder comprising: a housing having a housing wall to define an interior; a primary opening formed on the housing for receiving a dialysis bag for receipt therein; A plurality of through holes are formed in the housing such that the interior of the housing is in fluid communication with the outside. The dialysis bag holder of claim 1, wherein the housing is made of a material having a specific gravity greater than one such that the dialysis bag holder is completely immersed in the dialysate. The dialysis bag holder of claim 2, wherein the housing is made of medical grade plastic or metal material. The dialysis bag holder of claim 1 further comprising a cover adapted to engage the housing to close the primary opening. The dialysis bag holder of claim 4, wherein the cover has a first end pivotally connected to the housing, and a second end opposite the first end, a buckle is disposed at the second end And a member for fastening the cover body to the housing to close the main opening. The dialysis bag holder of claim 4, wherein the housing is formed to have a cylindrical shape, the main opening is formed at one end of the cylindrical housing, and wherein the main opening circumference is provided with a thread, and A corresponding thread is provided at the outer periphery of the cover such that the cover can close the main opening via screwing. The dialysis bag holder of claim 1, wherein the shell wall is further provided with a fastener for fixing to the dialysis tank.