M438912 ioiM438912 ioi
修正版修正日期：2012/7/31 五、新型說明： 【新型所屬之技術領域】 本創作係關於一種腹膜透析管，用於應用於實驗老鼠 之腹膜透析實驗中腹腔給藥或腹膜透析液之交換。 【先前技術】 腹膜透析係利用人體或動物體内之腹膜做為半滲透 膜，藉由腹膜透析管將腹膜透析液注入體内，注入的腹膜 透析液於腹膜兩側造成溶質濃度梯度差，而產生溶質彌散 作用與水为滲透作用，進而使通過人類或動物腹腔中的腹 膜透析液不斷更換，以達成體内廢物或毒性物質的代謝及 調整體内電解質平衡等目的，主要用於治療人類與動物的 腎衰竭等用途。 一般而言，當進行人體或動物的疾病治療時，藉由將 腹膜透析管一端植入患者或動物之體内，並將腹膜透析管 另一端連接至腹膜透析裝置，以將腹膜透析液輸送進入患 、者或動物體内，或將體内交換後之腹膜透析液帶走；而^ 行腹膜透析的實驗時，藉由將腹膜透析管―端植入實驗動 物之體内，並將腹膜透析管另一端藉由多管路接頭連接至 用於輸液之馬達及/或用於監控血壓等狀態之壓力感測哭 等雜外^ ’以使藥物或透析液藉*馬達的驅動而透^ 膜透析^管提供至實驗動物之體内，並同時提供感測監控等 其他功能以取得所需之實驗數據。 然而，習知腹膜透析管之種類繁多，其必須根據使用 3 修正版修正日期：2012/7/31 的對象進行選擇，即H、~小型動物或大型動物由於體内 器官組織之差異係有不同大小、長短的腹膜透析管的適 用；此外，應用的範圍亦影響腹膜透析管之選擇，具體而 言，用於疾病治療的腹膜透析管並不適合用於醫學實驗之 小型動物上，其係由於管徑、長短或例如袖套（cuff)等結構 而不利於小型動物體内之組織構造；又，研究目的之實驗 係需要大量的使用，而習知的腹膜透析管價格昂貴且不易 取得，而造成了實驗使用上的限制，進而影響了醫療科學 研究的發展。 【新型内容】 本創作的目的係提供一種腹膜透析管，其用於實驗老 鼠之腹膜透析實驗，並可增進腹膜透析管於腹膜透析實驗 中的操作便利性。 為達上述目的，本創作係提供一種腹膜透析管，係應 用於實驗老鼠之腹膜透析實驗，包含：一導管本體，係貫 穿有一液體通道並具有一液體進出部及一植管部，且該液 體進出部係設於該導管本體之一端並與該植管部相鄰；以 及一導彎件，係設於該植管部中，用以使該導管本體保持 彎曲形狀。 上述之腹膜透析管中，該導彎件係呈弧狀、勾狀、U 型或C型之不銹鋼絲，且該導彎件之直徑係小於該液體通 道之直徑。 上述之腹膜透析管中，該液體進出部係具有連通該液 101.hr 3 ί. ^ 年月‘·故 W 修正版修正日期：2012/7/31 f ' ___ι 一· 體通道之複數開口，該等~開口係彼此5隔排列;其中，該 等開口係可沿該導管本體之縱軸成列配置，且相鄰二列之 開口係彼此交錯；此外，該等開口係可為圓形。 因此’本創作實施例之腹膜透析管係可增進腹膜透析 實驗的便利性與操作性，而適用於實驗老鼠之小型動物的 腹膜透析實驗，並更加簡化習知腹膜透析管之結構，同時 可降低腹膜透析管之成本。 【實施方式】 為充分瞭解本創祚之目的、特徵及功效，茲藉由以下 之具體實施例，並配合所附圖式，對本創作做—詳細說明， 說明如後： 請參照第1圖及第2圖，第1圖係為本創作實施例之 腹膜透析管的示意圖；第2圖係為應用本創作實施例之腹 膜透析管進行腹膜透析實驗的示意圖。本創作實施例之腹 膜透析管1係應用於實驗老鼠100之腹膜透析實驗，主要 包含導管本體10及導彎件20，其中，導管本體10係貫穿 有液體通道11並具有液體進出部12及植管部13，且該液 體進出部12係設於該導管本體10之一端並與該植管部13 相鄰；導彎件20係設於該植管部13中，用以使該導管本 體10保持、f曲形狀。 於本貫施例中，該導彎件2〇係呈U型之不銹鋼絲，用 以使該導管本體10之軟質管體可保持彎曲形狀，並尤其於 實驗中的植管過程中及植入實驗動物體内後保持彎曲形 M438912 ί 〜〜_ _ . _ / 修正版修正日期：2012/7/31 狀，並且，該導彎件20之直徑係小於該液體通道之直徑， 以使置於液體通道11中之導彎件20不會阻礙液體流動傳 輸；此外，該導彎件20係用以使該導管本體1〇中的液體 通道11可形成一反轉路徑的型式’較佳為使該導管本體1〇 由體外部30延伸而反轉180度’而該導彎件2〇之形狀係 不限於本實施例之U型’而亦可呈狐狀、勾狀、u型或c 蜜等彎曲形狀。 於本實施例中，該液體進出部12係具有連通該液體通 道11之複數開口 14，該等開口 14係為圓形並彼此間隔排 列，用以使流通於液體通道11中的腹膜透析液或藥物可通 過該等開口 14而由實驗老鼠10〇之體内進出該腹膜透析管 1，用以進行實驗老鼠1〇〇之藥物或腹膜透析液之給予或取 出。其中，該等開口 14係可沿該導管本體1〇之縱軸成列 配置，且相鄰二列之開口 14係彼此交錯，以使藥物或腹膜 透析液可均勻順暢地提供至實驗老鼠1〇〇之體内。 如第2圖所示，本創作實施例之腹膜透析管1係應用 於貫驗老鼠100之腹膜透析實驗，用於腹腔給藥及腹膜透 析液之給予與取出’以進行模擬人體的腹膜透析之實驗， 舉例而言’本創作實拖例之腹膜透析管1係可進行腹膜透 析醒鼠模式或腹膜纖維化模式的實驗。 當進行腹膜透析管1植管時，事先將手術用器械與用 物經過滅麵消毒處理’首先將實驗老鼠100進行麻醉後， 將腹膜透析管1以該植管部13由手術切口 1〇1植入實驗老 乳100之腹腔中，而位於腹膜透析管1之另一端的體外部 6 101Revised revision date: 2012/7/31 V. New description: [New technical field] This is a peritoneal dialysis tube used for intraperitoneal or peritoneal dialysis in peritoneal dialysis experiments in experimental mice. exchange. [Prior Art] Peritoneal dialysis system uses the peritoneum of human or animal body as a semi-permeable membrane, and peritoneal dialysate is injected into the body through a peritoneal dialysis tube, and the injected peritoneal dialysate causes a difference in solute concentration gradient on both sides of the peritoneum. The solute dispersion and the water are osmotic, so that the peritoneal dialysate in the abdominal cavity of human or animal is continuously replaced, so as to achieve the metabolism of waste or toxic substances in the body and adjust the electrolyte balance in the body, etc., mainly for treating humans and Kidney failure and other uses of animals. In general, when treating a human or animal disease, the peritoneal dialysis solution is delivered by implanting one end of the peritoneal dialysis tube into the patient or animal and connecting the other end of the peritoneal dialysis tube to the peritoneal dialysis device. In the affected area, the animal or the animal, or the peritoneal dialysate after exchanging in the body; and in the experiment of peritoneal dialysis, the peritoneal dialysis tube-end is implanted into the body of the experimental animal, and the peritoneal dialysis is performed. The other end of the tube is connected to the motor for infusion by a multi-line connector and/or the pressure sensing for monitoring the state of blood pressure, etc., so that the drug or dialysate is driven by the motor. The dialysis tube is provided to the body of the experimental animal and provides other functions such as sensory monitoring to obtain the desired experimental data. However, there are many types of conventional peritoneal dialysis tubes, which must be selected according to the target of the revised version of 2012: 7/31, that is, H, ~ small animals or large animals have different organ tissues due to differences in internal organs. The application of the size and length of peritoneal dialysis tubing; in addition, the scope of application also affects the choice of peritoneal dialysis tubing. In particular, peritoneal dialysis tubing for disease treatment is not suitable for use in small animals for medical experiments. The diameter, length or structure such as cuff is not conducive to the tissue structure in small animals; further, the experimental purpose of the research purpose requires a large amount of use, and the conventional peritoneal dialysis tube is expensive and difficult to obtain, resulting in The limitations of the use of experiments have affected the development of medical science research. [New content] The purpose of this creation is to provide a peritoneal dialysis tube for experimental peritoneal dialysis experiments in old rats, and to improve the ease of operation of peritoneal dialysis tubes in peritoneal dialysis experiments. In order to achieve the above purpose, the present invention provides a peritoneal dialysis tube for use in a peritoneal dialysis test of an experimental mouse, comprising: a catheter body having a liquid passage therethrough and having a liquid inlet and outlet portion and a plant tube portion, and the liquid The inlet and outlet portions are disposed at one end of the conduit body and adjacent to the planting portion; and a curved member is disposed in the planting portion for maintaining the catheter body in a curved shape. In the above peritoneal dialysis tube, the curved member is an arc-shaped, hook-shaped, U-shaped or C-shaped stainless steel wire, and the diameter of the curved member is smaller than the diameter of the liquid passage. In the peritoneal dialysis tube described above, the liquid inlet and outlet portion has a fluid opening 101.hr 3 ί. ^年月'·故W Revised revision date: 2012/7/31 f ' ___ι 一 · The plural opening of the body passage, The openings are arranged in a spaced apart relationship from each other; wherein the openings are arranged in a row along the longitudinal axis of the catheter body, and the openings of the adjacent two columns are staggered with each other; further, the openings may be circular. Therefore, the peritoneal dialysis tubing of the present embodiment can enhance the convenience and operability of the peritoneal dialysis test, and is suitable for the peritoneal dialysis test of the small animal of the experimental mouse, and further simplifies the structure of the conventional peritoneal dialysis tube while reducing The cost of peritoneal dialysis tubing. [Embodiment] In order to fully understand the purpose, characteristics and efficacy of this creator, the following specific examples and the accompanying drawings are used to explain the creation in detail. The explanation is as follows: Please refer to Figure 1 and Fig. 2 is a schematic view showing a peritoneal dialysis tube of the present embodiment; and Fig. 2 is a schematic view showing a peritoneal dialysis test using the peritoneal dialysis tube of the present embodiment. The peritoneal dialysis tube 1 of the present invention is applied to the peritoneal dialysis test of the experimental mouse 100, and mainly includes a catheter body 10 and a curved member 20, wherein the catheter body 10 is through the liquid passage 11 and has a liquid inlet and outlet portion 12 and a plant. The tube portion 13 is disposed at one end of the catheter body 10 and adjacent to the planting portion 13; the bending member 20 is disposed in the planting portion 13 for the catheter body 10 Hold, f curved shape. In the present embodiment, the bending member 2 is a U-shaped stainless steel wire for maintaining the flexible shape of the flexible body of the catheter body 10, and especially during the implantation process and implantation in the experiment. The experimental animal remains curved in the body after M438912 ί ~~_ _ . _ / Revised revision date: 2012/7/31 shape, and the diameter of the guide member 20 is smaller than the diameter of the liquid passage, so as to be placed The curved member 20 in the liquid passage 11 does not hinder the liquid flow transmission; moreover, the curved member 20 is used to make the liquid passage 11 in the conduit body 1 into a reverse path. The catheter body 1〇 extends from the body exterior 30 and is reversed by 180 degrees. The shape of the curved member 2〇 is not limited to the U shape of the embodiment, and may also be a fox shape, a hook shape, a u shape or a c honey. Wait for the curved shape. In the present embodiment, the liquid inlet and outlet portion 12 has a plurality of openings 14 communicating with the liquid passage 11, and the openings 14 are circular and spaced from each other for the peritoneal dialysate flowing in the liquid passage 11 or The drug can pass through the opening 14 and enter and exit the peritoneal dialysis tube 1 from the test mouse for the administration or removal of the drug or the peritoneal dialysate of the experimental mouse. The openings 14 are arranged in a row along the longitudinal axis of the catheter body 1 , and the adjacent rows 14 of the openings 14 are staggered with each other so that the drug or peritoneal dialysate can be uniformly and smoothly provided to the experimental mouse. The body of the cockroach. As shown in Fig. 2, the peritoneal dialysis tube 1 of the present embodiment is applied to a peritoneal dialysis test of a rat 100 for intraperitoneal administration and administration and removal of peritoneal dialysate for performing human peritoneal dialysis. Experiments, for example, 'the peritoneal dialysis tube 1 system of this creation can be used for the experiment of peritoneal dialysis mode or peritoneal fibrosis mode. When the peritoneal dialysis tube 1 is implanted, the surgical instrument and the object are subjected to the surface disinfection treatment in advance. After the anesthetized mouse 100 is anesthetized first, the peritoneal dialysis tube 1 is treated by the surgical tube 13 from the surgical incision 1〇1 Implanted into the abdominal cavity of the experimental old milk 100, and outside the body at the other end of the peritoneal dialysis tube 1 6 101
補充I si 欲 年月日b j修正版修正日期：2012/7/31 川係由實驗老鼠100之鼠蹊部穿出，並利用手術用縫線將 手術接口 101缝合以固定該腹膜透析管i;其中，該腹膜透 析官1植管之過程係約5分鐘内完成。 當以腹膜透析管1進行右側股動脈及靜脈植管時，首 先將實驗老鼠100進行麻醉後，將腹膜透析管丨以該植管 部13由手術切口 1〇1植入實驗老鼠1〇〇之右側股動脈及靜 手術切口 101係維持在〇. 5χ〇.5公分以内，並利用手術 用缝線將手術接口 101縫合以固定該腹膜透析管1;待植管 手術完成之實驗老鼠1〇〇清醒後，將植入股動脈之腹膜透 析官1之體外部3〇連接3way接頭的其中一端，並將3way 接頭的另外二端分別作為後續血液採集口及連接壓力傳感 為’麗力傳感器係用於監測實驗老鼠100之血壓與心跳； 並且，植入股靜脈之腹膜透析管1之體外部30亦連接3way 接碩的其中一端，用於作為後續注射藥物之用藥口；其中， 該腹膜透析管1右側股動脈及靜脈植管之過程係約15分鐘 内元成。 當應用本創作實施例之腹膜透析管1於腹膜透析醒鼠 模式的實驗時，於實驗開始一週之後，將4.25%、30毫升 之腹膜透析液Dianeal經由腹膜透析管1注入不同組別之實 驗老鼠100的腹腔中，以進行實驗，其留置時間為4小時。 當應用本創作實施例之腹膜透析管1於腹膜纖維化模 式的實驗時，每曰將0.1%、0.5宅升之chlorhexidine digluconate以腹膜透析管1注入實驗老鼠100的腹腔中， 並持續一週的時間，以使實驗老鼠1〇〇產生腹膜硬化現象。 7 M438912Supplement I si 年月月日 bj revision revision date: 2012/7/31 Chuan is worn out by the squirrel of the experimental mouse 100, and the surgical interface 101 is sutured by surgical suture to fix the peritoneal dialysis tube i; The process of the peritoneal dialysis officer 1 tube is completed in about 5 minutes. When the right femoral artery and the vein tube were administered by the peritoneal dialysis tube 1, the experimental mouse 100 was first anesthetized, and the peritoneal dialysis tube was implanted into the experimental tube 1 by the surgical incision 1〇1. The right femoral artery and the sinus incision 101 were maintained within 5 χ〇.5 cm, and the surgical interface 101 was sutured by surgical suture to fix the peritoneal dialysis tube 1; the experimental mouse to be implanted was completed. After awake, the external 3〇 of the peritoneal dialysis unit 1 implanted into the femoral artery is connected to one end of the 3way joint, and the other two ends of the 3way joint are used as the follow-up blood collection port and the connection pressure sensor is the Lili sensor system. For monitoring the blood pressure and heartbeat of the experimental mouse 100; and, the external body 30 of the peritoneal dialysis tube 1 implanted in the femoral vein is also connected to one end of the 3way accessing base for use as a drug for the subsequent injection of the drug; wherein, the peritoneal dialysis The process of the femoral artery and vein graft on the right side of the tube 1 is within about 15 minutes. When the peritoneal dialysis tube 1 of the present embodiment was applied to the peritoneal dialysis mode, one week after the start of the experiment, 4.25%, 30 ml of the peritoneal dialysate Dieane was injected into the experimental group of different groups via the peritoneal dialysis tube 1. In the abdominal cavity of 100, the experiment was carried out, and the indwelling time was 4 hours. When the peritoneal dialysis tube 1 of the present embodiment was applied to the peritoneal fibrosis model, 0.1%, 0.5 liter of chlorhexidine digluconate was injected into the peritoneal cavity of the experimental mouse 100 with the peritoneal dialysis tube 1 for one week. In order to cause peritoneal sclerosis in the experimental mice. 7 M438912
AWAW
If. 修正版修正日期：2012/7/31 因此，本創作實施例之腹膜透析管係可增進腹膜透析 實驗的便利性與操作性，而適用於實驗老鼠之小型動物的 腹膜透析實驗，並更加簡化習知腹膜透析管之結構。 本創作在上文中已以較佳實施例揭露，然熟習本項技 術者應理解的是，該實施例僅用於描繪本創作，而不應解 讀為限制本創作之範圍。應注意的是，舉凡與該實施例等 效之變化與置換，均應設為涵蓋於本創作之範疇内。因此， 本創作之保護範圍當以申請專利範圍所界定者為準。 【圖式簡單說明】 第1圖係為本創作實施例之腹膜透析管的示意圖。 第2圖係為應用本創作實施例之腹膜透析管進行腹膜 透析實驗的示意圖。 、 【主要元件符號說明】 1 腹膜透析管 10 導管本體 11 液體通道 12 液體進出部 13 植管部 14 開口 20 導彎件 30 體外部 100 實驗老鼠 8 M438912If. Revised revision date: 2012/7/31 Therefore, the peritoneal dialysis tubing of the present embodiment can improve the convenience and operability of peritoneal dialysis experiments, and is suitable for peritoneal dialysis experiments of small animals in experimental mice, and more The structure of the conventional peritoneal dialysis tube is simplified. The present invention has been disclosed in the above preferred embodiments, and it should be understood by those skilled in the art that the present invention is only intended to depict the present invention and should not be construed as limiting the scope of the present invention. It should be noted that variations and permutations that are equivalent to the embodiment are intended to be within the scope of the present invention. Therefore, the scope of protection of this creation is subject to the definition of the scope of patent application. BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a schematic view showing a peritoneal dialysis tube of the present embodiment. Fig. 2 is a schematic view showing a peritoneal dialysis test using the peritoneal dialysis tube of the present embodiment. [Main component symbol description] 1 Peritoneal dialysis tube 10 Catheter body 11 Liquid channel 12 Liquid inlet and outlet 13 Planting tube 14 Opening 20 Guide member 30 Body exterior 100 Experimental mouse 8 M438912
修正版修正日期：2012/7/31 101 手術切口Revised revision date: 2012/7/31 101 Surgical incision