TWM421503U - Biomedical homogenizer - Google Patents

Biomedical homogenizer Download PDF

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Publication number
TWM421503U
TWM421503U TW100218889U TW100218889U TWM421503U TW M421503 U TWM421503 U TW M421503U TW 100218889 U TW100218889 U TW 100218889U TW 100218889 U TW100218889 U TW 100218889U TW M421503 U TWM421503 U TW M421503U
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Taiwan
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biomedical
wheel
power
wheels
rotating
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TW100218889U
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Chinese (zh)
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Yang-Te Hsu
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Yang-Te Hsu
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Priority to TW100218889U priority Critical patent/TWM421503U/en
Publication of TWM421503U publication Critical patent/TWM421503U/en

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M421503 五、新型說明 100年10月20日修正替換本 【新型所屬之技術領域】 本創作係關於-種生物醫學均質裝置,特別是關於— 種具有提升均質效果且同時具有低溫之生物醫學均 置。 、 【先前技術】 力子生物的研究領域巾’常需將各麟測試或鑑定之 =DNA、RNA或蛋自料叫取,方能進行後續各項 士 口子之檢/貝J及觀察。妓而言,舉凡各種組織 〔例如:. 心、肝、月等〕、細胞、菌苗等物質,皆可能於初處理 :摻雜其他雜質,甚至因組_體積過大而無法直接加以 徭I故通吊夕如用均質方式加以處理,使其可以適用於 後哨師選或純化之程序。 傳_質料㈣可_高_心'、超音波震盈或 ^ 口J等方式。其中,以組織均質化為例,通常係將欲g 二=織碎片裝置於—微管内,再由頭部具刀刀之機具: ^於高速運轉下’將該微管内的組織碎片吸入言 、白、之刀77部’而於空間間隙内進行剪切、分散等動作, 片微粒化之效果。⑯^ 快速達到組朗 於梦播纟’猎由轉統機具㈣之方式係容易 碎片^㈣化i效織碎片殘留^現象’而造成組織 洗X^ 几正,且,更可能因該機具頭部的清 菌等門題而^機具的重複使用下產生組織碎片污染、生 相+嚴重影響後續操作該組織碎片之實驗品質。 —3 — 100年10月20 S修正替換本 因此’目刖多透過高速離心之方法進行組織、細胞等 物質的均質化作業’且市面上也已發展有高速離心式之均 質機’如志德國際有限公司所販賣之BuIlet BienderTM均質 機。以組織均質化為例’其係先於«有欲均質化組織之 微官内’另外放入至少-磁珠’再將該微管放置於該均質 機所設置之插槽内,並透過該均質機的高速離心,使得該 磁珠能於該微管内反覆撞擊欲均質化之組織,達到組織碎 化、均質之目的。 然而,上述高速離心式之均質機僅能帶動置放該微管 之插槽同步旋轉,而產生高速離心之效果。如此,該磁珠 反覆於該微管喊生撞擊之醉係受限於該均韻的離心 轉速’而無法於固定轉速下再增加該磁珠於微管内的反覆 撞擊頻率,導舰_質化之效較卿顯關;甚至, 於同步高速離心旋轉之情況下,係容易使該磁珠落於該微 管之底部,而僅能於該微管底部產生頻繁之微震盪,始終 無法全面性的撞擊該微管内欲均質化之組織嚴重影響該 組織均質化之效果,以及後續操作該均進行筛選、 純化或鑑定之實驗品質。 有鑑於此,確實有必要發展一種可提升均質效果之生 物醫學均貝裝置’以透過承裝微管之盒體同步且獨立之高 速離心,解決如上所述之各種問題。 【新型内容】 本創作主要目的乃改善上述缺點,以提供一種生物醫 學均質裝置’其係能約於固定轉速下增加磁珠於微管内的 100年10月20日修正替換本 反覆撞擊頻率,以提升物質均質化之效果者。 本創作次一目的係提供一種生物醫學均質裝置,係能 夠全面性的撞擊微管内欲均質化之物質,以具物質完整均 質之效果且維持後續實驗之品質者。 本創作再一目的係提供一種生物醫學均質裝置,係能 夠於低溫環境完成均質作業,以提升均質效果及敦置使用 性者。 為達到前述創作目的,本創作之生物醫學均質裝置, 係包含:一座體,設有二組動力輪,該動力輪係設置於該 座體之相對應内壁;一旋轉組件,係可轉動地組裴於該二 座體之間,該旋轉組件係包含一主動軸及二轉盤,該二轉 盤係分別設置於鄰近該主動軸之二端處,且該主動軸之二 端係分別能二組:動力輪相互組接,該二轉盤皆分別設有 .、且從動輪,該動力輪帶動從動輪相對於轉盤旋轉; 少一容置構件,係可轉動地設置於該二轉盤 從動輪相互組接。 且與该 其中’該至少動力輪係由二_之動力輪 共同疊 合而成。且 ,各組鶴輪係由二相同絲之 遠二轉盤之各組從動輪係呈相互錯位配置。輪構成’ 其中’該主動軸之二端分別貫穿該二組動 :入動軸的其中一端設有一動力源…:传於 卡&amp;:該主動軸二端的各-卡接部,且由-扣環予:二別 者’該從動輪係具有—轉動部及—組接部,兮轉: :係:於該轉盤旋轉,且該組接部 般 面,从由該組接部供哕交里 皿之内表 丨彳/、心置構件城,且限_容置構件 10〇年10月20日修正替換本- 位於該二轉盤之間。且,該二轉盤未設有轉動部之處另設’ 有數組接件,s亥組接件可以相對於該轉盤旋轉。 其中’該容置構件之-端係組設於該從動輪之組接 部’且該容置構件之另一端係組設於該轉盤之組接件。且, 該容置構件内係區分有數容槽,該數容槽係以一蓋板予以 封閉,且該蓋板係組設於該容置構件之周緣。 此外,本創作生物醫學均質裝置還可以於該主動車由外·. 周壁,有-磁性件,該磁性件係包覆於該主動⑽周壁, 用以,供磁力。且’該座體内更可以另設置—氣體循環組φ 件,藉以控制該座體内部之空氣溫度,較佳維持於4它之 均質環境。 ' 【實施方式】 目的、特徵及優點能更明顯 實施例’並配合所附圖式, 為讓本創作之上述及其他 易懂,下文特舉本創作之較佳 作詳細說明如下: 明以'弟1圖所示’其係為本創作一較佳實施例,該 生物醫學均料置係包含—座體丨…旋轉組件^至少 -谷置構件3 ’該旋轉組件2係可轉動地組裝於 且該旋轉組件2侧轉_容置餅3之 係能將數微管4〔如筮2 θ 精此* 〔如弟3 ®所示〕放置於餘置構件3 置構件3隨該旋轉組件2產生同步旋轉及獨 立旋轉之時,增加备呼舛狄 焚轉及獨 物質全面性内的磁珠41撞擊頻率,達到 物貝王面丨生碎化、均質之功效。 ’广體1僅供作為該旋轉組件2支樓或容置之用,故 1QQ年10月20曰修正替換本 不於此限制該座體1所應呈現之態樣。牲&amp;丨及 _ 知別係如第2圖所 示’本實施例之座體1可以具有一容置办 直二間s,用以供該 旋轉組件2組裝於該容置空間S内。且,可,、, .且可U於該座體工 開設有一取物窗口 W’該取物窗口 W較佳係以—啟閉蓋板 B予以密合。甚至,更可以選擇性的於該座體工另^有 其他設備〔例如:氣體循環組件等〕,以便本創作生物醫 學均質裝置可以較為廣泛地加以利用。 請配合參照第1及2圖所示’該座體1設有至少一動 力輪11 ’該動力輪11可以被_動力源驅動’在本實施例 當中’該動力源Μ可以為一馬達,該動力輪u可以設置 於該座體1之相對助壁,以呈二__之動力輪n。 於本實施例中,該至少一動为卜 夕勒刀輪11係可以由二動力輪共同 組成,且較佳係選擇由具相同齒數之二齒輪相互疊合,以 便該旋轉組件2帶動各該容置構件3旋轉時,可以使各該 容置構件3呈相同離心轉速進行均質化作業。 該㈣組件2係可轉動地組裝於該座體},較佳係組 接於Ha動力輪n之間。本實施例之旋轉組件2係包含 -主動軸2i及二轉盤22,該主_ 21係與該二組動力輪 11相互、,且接,特別係由該主動轴之二端分別貫穿該二 組動力輪11 ’且於該主動軸21的其中—端設有—動力源 Μ ’以由杨力源M輸出動力而帶動該旋轉組件2之旋 轉°再且’該主動轴21之二端分別設置有該二轉盤22, 該f轉盤22較佳係各別卡合於該主動轴二端的各-卡 接°卩 且由扣環212加以固定,以確保該二轉盤22 可隨該主動軸21呈同步轉動。 2Π 21 係包覆於該主動轴21之圖^圖辟面,’曰該磁性件213較佳 管4内之磁珠41。Α :生:此提供磁力以吸引該微 但不限制於完整包覆^1 之設置態樣係選擇 可^主動轴21,係屬熟習該技藝之人士 T輕易理解,不再於此詳細說明。 之設圖所示’本創作係可對應該動力輪11 Ρ &amp;旦不魏的於該旋轉組件2之二轉盤22皆設有 動輪23〔即由二相同齒數之從動輪成-組,以下簡 2。2動輪23 〕’以藉由該從動輪23接合該容置構 。〜錢輪23可峨動力輪u㈣及相對於轉盤^ 2轉’該帶動方式可為習知之各種帶動方式,.例如:利用 合於該二者之間’作間接傳動;或者在該轉盤U 外周緣設-環内齒,該從動輪23與該内齒喷合;或如本實 施例所示,該從動輪23與動力輪n之間以鏈條、皮帶等 連動件24帶動㈣。於實施例中,該三触22之從動輪 =較佳係呈相互錯減i,特別如第i圖之圖面所示 仔該一轉盤22之從動輪23相互呈十字交會之設置態樣, 以便供各該容置構件3組裝時,能夠使各該容置構件3間 留有較適當之間距’避免影響離心時的轉動效果。且,於 該二轉盤22未設置有該從動輪μ之處另設有數組接件 221 ’該組接件221係可以相對於該轉盤22定位旋轉,且 該數組接# 22!與該從動輪23相互對應,用以承接該容置 構件3之一端。 其中,該從動輪23中的各該從動輪23皆分別具有一 M421503M421503 V. New Description 100 October 20th Revision Replacement [New Technical Field] This creation is about biomedical homogenization devices, especially for biomedical applications with improved homogenization and low temperature . [Prior Art] The research field of Lizi Biological is often required to test the DNA, RNA or egg of each lining test or identification, in order to carry out subsequent inspections of the syllabus. In other words, all kinds of tissues (such as: heart, liver, month, etc.), cells, vaccines, etc., may be treated at the beginning: doping other impurities, or even because the group _ volume is too large to be directly The hoisting method can be applied in a homogeneous manner to make it suitable for the procedure of the post-sequence selection or purification. Pass _ material (four) can be _ high _ heart ', ultrasonic shock or ^ mouth J and other methods. Among them, taking tissue homogenization as an example, it is usually the device that is to be used in the microtubule, and then the tool with a knife in the head: ^ Under high speed operation, the tissue fragments in the microtube are inhaled. The white and the knives are 77's, and the action of cutting, dispersing, etc. in the space gap, and the effect of the microparticulation. 16^ Quickly reach the group in the dream broadcast 纟 'hunting by the turning machine (four) is easy to fragment ^ (four) i-woven woven debris residue ^ phenomenon 'cause tissue washing X ^ a few positive, and more likely due to the machine head Part of the cleansing and other problems and the repeated use of the machine to produce tissue debris pollution, phase + seriously affect the experimental quality of the subsequent operation of the tissue fragments. —3 — October 20, 20 S Correction of the replacement of the material, so that the homogenization of tissues and cells is carried out by means of high-speed centrifugation, and a high-speed centrifugal homogenizer has been developed on the market. BuIlet BienderTM homogenizer sold by International Limited. Taking tissue homogenization as an example, the system is placed in the slot set by the homogenizer and placed in the slot of the homogenizer before the micro-manufacture of the desired homogenization organization. The high-speed centrifugation of the homogenizer enables the magnetic beads to repeatedly collide with the tissue to be homogenized in the microtube to achieve the purpose of tissue fragmentation and homogenization. However, the high-speed centrifugal homogenizer described above can only drive the slots in which the microtubes are placed to rotate synchronously, resulting in high-speed centrifugation. In this way, the magnetic beads repeatedly overwhelm the dripping of the microtube and are limited by the centrifugal speed of the homogeny, and the repeated impact frequency of the magnetic bead in the microtube cannot be increased at a fixed rotational speed. The effect is better than that of the Qing; even in the case of synchronous high-speed centrifugal rotation, the magnetic beads are easy to fall on the bottom of the microtube, and only frequent micro-shocks can be generated at the bottom of the microtube, and the comprehensiveness is always impossible. The impact of the tissue to be homogenized in the microtube seriously affects the homogenization effect of the tissue, and the experimental quality of screening, purification or identification for subsequent operations. In view of the above, it is indeed necessary to develop a biomedical meandering device that can improve the homogenization effect to solve various problems as described above by synchronizing and independently performing high-speed centrifugation through a casing for holding microtubules. [New content] The main purpose of this creation is to improve the above-mentioned shortcomings, so as to provide a biomedical homogenizing device, which can increase the repetitive impact frequency by adding the magnetic beads to the microtubes at a fixed rotational speed on October 20, 100. Improve the effect of material homogenization. The second objective of the present invention is to provide a biomedical homogenizing device which is capable of comprehensively impacting substances to be homogenized in the microtubules, to achieve the effect of complete homogeneity of the substance and to maintain the quality of subsequent experiments. A further objective of the present invention is to provide a biomedical homogenization device that is capable of performing homogenization operations in a low temperature environment to enhance homogenization and disability. In order to achieve the above-mentioned creative purpose, the biomedical homogenizing device of the present invention comprises: a body having two sets of power wheels, the power wheel train is disposed on a corresponding inner wall of the seat body; and a rotating component is rotatably assembled Between the two bodies, the rotating component comprises a driving shaft and two rotating wheels, the two rotating wheels are respectively disposed adjacent to the two ends of the driving shaft, and the two ends of the driving shaft are respectively capable of two groups: The power wheels are connected to each other, and the two rotary wheels are respectively provided with a driven wheel, and the power wheel drives the driven wheel to rotate relative to the turntable; and one less receiving member is rotatably disposed on the two turntable driven wheels. . And in combination with the power wheel of the second power wheel. Moreover, each group of crane wheels is arranged in a mutually dislocated configuration by the set of driven wheels of the far two turntables of the same wire. The wheel constitutes 'where' the two ends of the drive shaft respectively penetrate the two sets of movements: one end of the input shaft is provided with a power source...: transmitted to the card &amp;: the respective end of the drive shaft - the snap portion, and by - Buckle ring: two other persons' the driven gear train has a rotating part and a connecting part, and the turning: : is: rotating on the turntable, and the set of joints is like a face, and the joint is supplied by the joint The inside of the dish is 丨彳/, the heart is set to the member city, and the limit _ accommodating member 10 October 20th revised replacement - located between the two turntables. Moreover, the two turntables are not provided with a rotating portion, and there is an array connector, and the sigma assembly can be rotated relative to the turntable. Wherein the end of the accommodating member is disposed at the assembly portion of the driven wheel and the other end of the accommodating member is assembled to the assembly of the turntable. Moreover, the accommodating member is divided into a plurality of pockets which are closed by a cover plate, and the cover plate is assembled on the periphery of the accommodating member. In addition, the biomedical homogenizing device of the present invention can also be used for the magnetic force of the active vehicle from the outer wall. The magnetic member is coated on the active (10) peripheral wall for magnetic force. And the body can be further provided with a gas circulation group φ to control the temperature of the air inside the body, preferably maintained at 4 in its homogeneous environment. [Embodiment] The objects, features and advantages of the present invention can be more clearly described in the accompanying drawings. In order to make the above and other aspects of the present invention easy to understand, the following is a detailed description of the preferred embodiment of the present invention as follows: 1 is a preferred embodiment of the present invention, the biomedical material assembly includes a body 丨 ... a rotating component ^ at least - a valley member 3 ' the rotating component 2 is rotatably assembled and The rotating component 2 is rotated to the side of the cake 3 to place a plurality of microtubes 4 (such as 筮 2 θ fine this * (as shown by the brother 3 ® ) in the remaining member 3; the member 3 is produced with the rotating component 2 During synchronous rotation and independent rotation, the frequency of impact of the magnetic beads 41 in the comprehensive combustion of the material and the uniformity of the material is increased, so as to achieve the effect of shattering and homogenizing the material. 'Guangdong 1 is only used as a 2 building or accommodation for the rotating component. Therefore, the replacement of this block 1 October 1QQ is not limited to the aspect that the block 1 should present. The cradle &amp; </ RTI> and the _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ Moreover, it is possible to open an object window W' in the body of the seat, and the object window W is preferably closed by the opening and closing cover B. In addition, it is more optional to have other equipment (such as gas circulation components, etc.) in the body, so that the biomedical homogenizer can be widely used. Referring to FIGS. 1 and 2, the seat body 1 is provided with at least one power wheel 11'. The power wheel 11 can be driven by a power source. In the present embodiment, the power source can be a motor. The power wheel u can be disposed on the opposite auxiliary wall of the seat body 1 to be a power wheel n of two __. In this embodiment, the at least one motion is the Bucher wheel 11 can be composed of two power wheels, and preferably two gears having the same number of teeth are superposed on each other, so that the rotating component 2 drives each of the capacities. When the member 3 is rotated, each of the accommodating members 3 can be homogenized at the same centrifugal speed. The (4) component 2 is rotatably assembled to the base body}, preferably between the Ha power wheels n. The rotating component 2 of the embodiment includes a driving shaft 2i and two rotating wheels 22, and the main _21 system and the two sets of power wheels 11 are connected to each other, in particular, the two ends of the driving shaft respectively penetrate the two groups The power wheel 11' is provided with a power source Μ at the center end of the driving shaft 21 to drive the rotation of the rotating component 2 by the output of the Yangli source M. Further, the two ends of the driving shaft 21 are respectively disposed. The two turntables 22 are preferably respectively engaged with the respective snaps of the two ends of the drive shaft and fixed by the buckles 212 to ensure that the two turntables 22 can rotate synchronously with the drive shaft 21. . 2Π 21 is wrapped around the driving shaft 21, and the magnetic member 213 is preferably a magnetic bead 41 in the tube 4. Α: Health: This provides a magnetic force to attract the micro, but is not limited to the complete setting of the cover ^1. The drive shaft 21 is a person familiar with the art. T is easy to understand and will not be described in detail. As shown in the figure, the present invention can be equipped with a moving wheel 23 corresponding to the rotating wheel 2 of the rotary unit 2 (i.e., the driven wheel of the same number of teeth is formed into a group, corresponding to the power wheel 11 amp &amp; The simple 2. 2 moving wheel 23]' is engaged with the receiving structure by the driven wheel 23. ~ Money wheel 23 can be powered by the power wheel u (four) and relative to the turntable ^ 2 turn 'this driving mode can be a variety of conventional driving methods, for example: using the indirect transmission between the two; or in the periphery of the turntable U The rim is provided with a ring inner tooth, and the driven wheel 23 is sprayed with the inner tooth; or as shown in the embodiment, the driven wheel 23 and the power wheel n are driven by a link 24 such as a chain or a belt (4). In the embodiment, the driven wheels of the three-touch 22 are preferably mutually offset, i, in particular, as shown in the drawing of the first drawing, the driven wheels 23 of the one turntable 22 are arranged in a cross-crossing manner. In order to allow each of the accommodating members 3 to be assembled, it is possible to leave a proper spacing between the accommodating members 3 to avoid affecting the rotational effect during centrifugation. Moreover, when the second turntable 22 is not provided with the driven wheel μ, an array connector 221 is further provided. The set of connectors 221 can be rotated relative to the turntable 22, and the array is connected to #22! and the driven wheel. 23 corresponds to each other for receiving one end of the accommodating member 3. Wherein, each of the driven wheels 23 of the driven wheel 23 has a M421503

轉動部231及-《且接 _年1〇月2◦日修正替換本 該轉盤22旋轉,且t 該轉動物係可以相對於 内表面,由該組接部接部232較佳係設於該轉盤。之 限制該容置構件3位於誃二 禚組裝,且 23之轉動部231對庫二了 Β ’亚使各該從動輪 η可以帶動該從動輪 之動力輪11,使該動力輪 勒輪23相對應於轉盤22旋The rotating portion 231 and the "receiving" are replaced by the rotation of the turntable 22, and the rotating object can be rotated relative to the inner surface, and the set of connecting portions 232 is preferably attached to the rotating portion 231. Turntable. Limiting that the accommodating member 3 is located in the 誃 禚 assembly, and the rotating portion 231 of the second 对 对 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚 亚Corresponding to the turntable 22

為了因應本實施例多組動力輪11及多組從動輪23之 ,置,本讓一彻㈣触=2 ==且Γ連動件24較佳係為可帶動齒== ^條或皮U各該連料24皆分_繞接設於該動 2及從動輪23,以由該連動件%的環繞運動帶動該動力 兩11及伙動輪23旋轉’特卿該動力輪n之齒數大於 從動輪23之齒數’而可以迫使該從動輪23 _ 轉動。 人义符歡又·In order to respond to the plurality of sets of the power wheel 11 and the plurality of sets of the driven wheels 23 of the present embodiment, the pinch (4) touch = 2 == and the linker 24 is preferably a movable tooth == ^ strip or a skin U The connecting material 24 is divided and disposed on the movable 2 and the driven wheel 23 to drive the power 11 and the partner wheel 23 to rotate by the surrounding motion of the linkage member. The number of teeth of the power wheel n is larger than the driven wheel. The number of teeth '23' can force the driven wheel 23_ to rotate. Humanity and happiness

請配合參照第1及3圖所示,各該容置構件3係可轉 動地設置於該二轉Μ 22之間,較佳係於各該$置構件3 相對應之二侧壁設一組接孔31,使得各該容置構件3 一端 之組接孔31組设於該從動輪23之組接部232,且各該容 ί構件3另一端之組接孔31則組設於該轉盤22之組接件 221。其中,該容置構件3之形狀及尺寸設計,僅係以能夠 承裝數微管4且組設於該旋轉組件2之二轉盤22間為主要 原則,故不於此加以限制該容置構件3所應呈現之態樣。 特別的是,如第3圖所示,該容置構件3内係區分有 數容槽32,且各該容槽32之徑裏係配合該微管4之徑寬 設計,以使該微管4能夠容置於該容槽32内,且不於該容 —9 1〇0年10月20日修正替換本 槽32内產生過度左右晃動為較佳原則, =所能輕易理解„,不再多加贅述。且,該容置構ί = ^ 33加以封閉’該蓋板33較佳係組設 於該谷置構件3之周緣’以便於開啟及閉合,尤其係可以 ”合I達到較佳的緊固致果,不至於高速離心時發生該 盍板33 ’鬆脫而導致微管4掉落之情形。 =!·、注意的是’本創作生物醫學均質裝置係能承上所 圖所二广於該座體1内另設置-氣體循環組件5〔如第2 匕斤不〕,以由該氣體循環組件5控制該座體 激度,使得本創作生物醫學均f裝置能夠提 = 化環境,較佳係維持於4t之低溫情形下’以廣泛 ==組織、細胞或菌種。且’更可以於該座體工之外 土-置-雜件6 ’以由該調控件6的面板控制選單 握本創作生物1學均質U於均質過程的高速離心轉速,Referring to FIGS. 1 and 3, each of the accommodating members 3 is rotatably disposed between the two turns 22, preferably disposed on a pair of side walls of the respective members 3; The connecting holes 31 are formed in the connecting portion 232 of the driven wheel 23, and the connecting holes 31 at the other end of each of the receiving members 3 are assembled on the turntable. The set of members 221 of 22. The shape and size of the accommodating member 3 are mainly designed to be able to receive the micro-tubes 4 and are disposed between the two rotating discs 22 of the rotating assembly 2, so the accommodating member is not limited thereto. 3 should be presented. In particular, as shown in FIG. 3, the accommodating member 3 is divided into a plurality of pockets 32, and the diameter of each of the pockets 32 is matched with the diameter of the microtube 4 so that the microtube 4 is designed. It can be accommodated in the pocket 32, and it is not preferable to correct the excessive left and right sloshing in the groove 32 on October 20th, 2009. It is easy to understand „, no more Further, the accommodating structure ί = ^ 33 is closed. The cover plate 33 is preferably disposed on the periphery of the valley member 3 to facilitate opening and closing, in particular, it can achieve a better tightness. The solid fruit does not cause the slab 33' to loosen when the high-speed centrifugation occurs, causing the microtubule 4 to fall. =!·, Note that 'this creation biomedical homogenization device can carry the other two in the body 1 - gas circulation component 5 (such as the second 匕 不 not) to circulate the gas The component 5 controls the activation of the block so that the biomedical device can provide a solution to the environment, preferably maintained at a low temperature of 4 t, with a wide range of == tissues, cells or strains. And 'more can be outside the body of the body - set - miscellaneous pieces 6 ' with the panel control menu of the control 6 to grasp the high-speed centrifugal speed of the homogenization process

f及各種__、細胞«種所適合之環境溫度,達到 較佳的物質均質化之功效。 達J 質裝US,5圖所示’其僅係為本創作生物醫學均 J &quot;座體1、旋轉組件2及數容置構件3的1 — 祕,_此說明本創作於均f過㈣作動情形。,、 質化j:本創作生物醫學均質裝置前,係先選擇將欲均 徽其、〔例如:動物组織、細胞或菌種等〕添加於該 4内’且同時於該微管4内置人至少—磁珠41〔 六ί將配置完成之數隻微管4分別放置於各該 奋 之谷槽31内,且透過該調控件6設定適當之 速及溫度,以同時進行均質化之作業。如此,藉由該動力 _ Α/Γ .Λ , , 100年10月20日修正替招 源Μ輸出動力以驅動該旋轉組 使架設於爹旋辨&amp;日^^ ? 動軸21轉動’且 呈同;=時Γ轉盤22間的數容置構件3可以 乂軺動,门蚪,玟置於該二轉盤” 該二轉盤22同步產生旋轉,動輪23係&amp; 置於該座體⑽之_„=^ I繼 11可以帶動該從動輪23旋轉使0上該動力輪 效應,使得组接於該從動輪23之^^;^ ί自轉 轉組件2呈同步轉動外,更二::二亥: ^ 3 ^ ^ 田必伙勖輪23帶動該容置 構件3呈獨立旋轉’以於穩定的轉速下,增加該容置構件 均:::r—管二: 二T、上所述’本創作生物醫學均質裝置之主要特徵在 糾精由該動力輪U及從動輪23的共同連接配置,係使 =疋轉組件2可輕易帶動該容置構件3呈同步及獨立之旋 轉於穩定的轉速下,增加該容置構件3 _轉頻率, 入提升D亥磁珠41於該微管4内的反覆碰撞次數,而可以 :=I*生的心擊該微管4内欲均質化之物質,達到提升物質 句貝化之功效。甚至,當本創作生物醫學均質裝置於中高 ,速作業日宁’仍可藉由增加該容置構件3的翻轉頻率,而 、’隹持有較佳的均質化效果;更不會因長時間的高速旋轉, 產,如.傳統磁珠41落於該微管4底部之情形,故本創作生 一 W學均質裂置可不受限於離心轉速之快慢.,而同樣維持 穩定均質化之功效。 t倉Η乍生物醫學均質裝置係能夠於固定轉速下增加 確珠於微管内的反覆撞擊頻率,以達到提升物質均質化之 —11 — 100 年]〇 月 2〇 η 功效。 卻日修正替換本 內欲學1質:置係能夠全面性的撞擊微管 後續實驗較佳品質之功效物f完整均質之效果,達到维持 質作二醫二質裝置係能夠於低溫環境完成均 細胞或菌種,:二織、. 以限^^=作已利=述触實施例揭示,然其並非用· 和範鬥μ,任何沾習此技藝者在不脫離本創作之精神孀 ^圍之内,相對上述實施例進行各種更動與修改仍屬本 創:所保護之技術範嗨,因此本創作之保護範圍當視後附 之申凊專利範圍所界定者為準。 【圖式簡單說明】 第1圖:本創作生物醫學均質裝置之立體分解圖。 第2圖··本創作生物醫學均質裝置之組合 圖。 μ 第3圖:本創作线醫學均質裝置之部分構件示意圖。 第4圖:本創作生物醫學均質裝置之組合配置剖面示轰 圖。 ^ 第5圖:本創作生物醫學均質裝置之作動示章圖。 【主要元件符號說明】 〔本創作〕 —12 —f and various __, cells «the appropriate ambient temperature to achieve better material homogenization. Up to J quality US, shown in Figure 5, which is only for the creation of biomedical J &quot; seat 1, rotating component 2 and number of components 3 - secret, this description of the creation of the f (4) Acting situation. , qualitative j: before the creation of the biomedical homogenization device, the first choice is to add the average emblem, such as: animal tissue, cells or strains, etc. in the 4' and at the same time built in the microtube 4 At least the magnetic beads 41 [the six micro-tubes 4 arranged in the arrangement are placed in each of the Fen Valley troughs 31, and the appropriate speed and temperature are set through the adjustment control 6 to simultaneously perform the homogenization operation. . Thus, by the power _ Α / Γ Λ , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , The same can be used; the number of the accommodating members 3 between the turrets 22 can be moved, the sills and sills are placed on the two turrets. The two turrets 22 are synchronously rotated, and the moving wheels 23 are &amp; placed in the pedestal (10) _„=^ I I can drive the driven wheel 23 to rotate to make the power wheel effect, so that the self-rotating component 2 connected to the driven wheel 23 rotates synchronously, and more:二海: ^ 3 ^ ^ The Tiebi 勖 wheel 23 drives the accommodating member 3 to rotate independently'. At a steady speed, the accommodating member is increased:::r-tube 2: two T, above The main feature of the creation of the biomedical homogenization device is that the rectification is configured by the common connection of the power wheel U and the driven wheel 23, so that the rotation member 2 can easily drive the accommodating member 3 to rotate synchronously and independently at a stable rotation speed. Next, the accommodating member 3 _ turn frequency is increased, and the number of repeated collisions of the D hai magnetic beads 41 in the micro tube 4 is increased, and the heartbeat of the =I* raw can be: 4 microtubules within the substances to be homogenized, to enhance the effectiveness of shell material of the sentence. Even when the biomedical homogenization device of the present invention is in the middle and high, the speed operation of the Ning' can still increase the turning frequency of the accommodating member 3, and the 隹 holds a better homogenization effect; The high-speed rotation, production, such as the traditional magnetic bead 41 falls on the bottom of the micro-tube 4, so the creation of a W-synchronous split can not be limited to the speed of the centrifugal speed, while maintaining the effect of stable homogenization . The t-clog biomedical homogenization device is capable of increasing the repetitive impact frequency of the beads in the microtube at a fixed rotational speed to achieve the effect of improving the homogenization of the material by 11 to 100 years. However, the daily correction is to replace the one in the original quality: the system can comprehensively impact the microtubules. The subsequent experiments are better quality of the effect of the substance f complete homogenization effect, to achieve the quality of the second medical device can be completed in a low temperature environment Cell or strain,: two weaving,. limit ^ ^ = for profit = touch the embodiment to reveal, but it is not used · and Fan Dou μ, anyone who is accustomed to this artist does not leave the spirit of this creation The various changes and modifications to the above embodiments are still within the scope of the invention. The scope of protection of the present invention is subject to the definition of the scope of the patent application. [Simple description of the diagram] Figure 1: An exploded view of the biomedical homogenization device. Figure 2 · Combination of biomedical homogenization devices. μ Fig. 3: Schematic diagram of some components of the medical homogenization device of this creation line. Figure 4: A cross-sectional view of the combined configuration of the biomedical homogenizer. ^ Figure 5: Actuation diagram of the biomedical homogenization device. [Description of main component symbols] [This creation] —12 —

M421503 • 100年10月20日修正替換本 1 座體 11 動力輪 2 旋轉組件 21 主動轴 211 卡接部 212 扣環 213 磁性件 22 轉盤 221 組接件 23 從動輪 231 旋轉部 232 組接部 24 連動件 3 容置構件 31 組接孔 32 容槽 33 蓋板 4 微管1 41 磁珠 5 氣體循環組件 6 調控件 S 容置空間 W 取物窗口 B 啟閉蓋板 Μ 動力源 13 —M421503 • October 20th, 100th Revision Replacement 1 Seat 11 Power Wheel 2 Rotary Assembly 21 Drive Shaft 211 Knuckle 212 Buckle 213 Magnetic 22 Turntable 221 Assembly 23 Drive Wheel 231 Rotating Port 232 Assembly 24 Linkage 3 accommodating member 31 assembly hole 32 accommodating groove 33 cover plate 4 micro tube 1 41 magnetic beads 5 gas circulation assembly 6 adjustment control S accommodation space W acquisition window B opening and closing cover Μ power source 13 —

Claims (1)

M421503 100年10月20日修正替換本 六、申請專利範圍: • 1、一種生物醫學均質裝置,係包含: 一座體,設有二組動力輪,該動力輪係設置於該座體之 相對應内壁; 一旋轉組件,係可轉動地組裝於該動力輪之間,該旋轉 組件係包含一個主動軸及二個轉盤,該二轉盤係分別設. 置於鄰近該主動軸之二端處,且該主動軸之二端係分別 與該二組動力輪相互組接,該二轉盤皆分別設有一組從 動輪,該動力輪可以帶動各從動輪旋轉;及 至少一容置構件,係可轉動地設置於該二轉盤之間,且 與該從動輪相互組接。 ~ 2、依申請專利範圍第1項所述之生物醫學均質裝置,其 中,各組動力輪係由二相同齒數之動力輪共同疊合而 成,且各組從動輪係由二相同齒數之從動輪構成。 3、 依申請專利範圍第1或2項所述之生物醫學均質裝置, 其中,該主動轴之二端分別貫穿該二組動力輪,且於該 主動軸的其中一端設有一動力源。 4、 依申請專利範圍第1或2項所述之生物醫學均質裝置,. 其中,該從動輪係具有一轉動部及一組接部,該轉動部 可以相對該轉盤旋轉,該組接部設於該轉盤之内表面, 該組接部供該容置構件組裝,且限制該容置構件位於該 二轉盤之間。 5、 依申請專利範圍第4項所述之生物醫學均質裝置,其 中’該二轉盤未設有該從動輪之處另設有數組接件’該 14 — ⑽年10月20曰修正替換本 組接件可以相對該轉盤旋轉。 依申請專利範圍第5項所述之生物醫學均質裝置,1 置構件之—端係祕於該從動輪之組接部,i &quot;合件之另―端偏設於雜叙組接件。 ::請專利範圍第“戈2項所述之 f’該蝴_壁設有一個磁性件,該磁性件/包 覆於該主動轴外周壁,用以提供磁力。 範圍第1或2項所述之生物醫學均質裝置, 體内部度設置™氣體循環組件,崎制該座 9 依申請專鄕㈣1或2項所述之生物醫學均 10 f中’該二魅係各料合賊絲軸二端的各—'卡接 邛,且由一扣環予以固定。 接 2睛專利範圍第丨或2項所述之生物醫學均質裝置, 該容置構件内係區分有數容槽,該數容槽係以-予以封閉’且該蓋板係組設於該容置構件之周緣。 15 M421503 100年10月20日修正替換本 四、指定代表圖: (一) 本案指定代表圖為:第(1 )圖。 (二) 本代表圖之元件符號簡單說明: 1 座體 11 動力輪 2 旋轉組件 21 主動軸 211 卡接部 212 扣環 213 磁性件 22 轉盤 221 組接件 23 從動輪 231 旋轉部 232 組接部 24 連動件 3 容置構件 31 組接孔 Μ 動力源M421503 October 20, 100 revised replacement of the sixth, the scope of application for patents: • 1, a biomedical homogenization device, comprising: a body, with two sets of power wheels, the power wheel system is set in the corresponding body An inner wall; a rotating assembly rotatably assembled between the power wheels, the rotating assembly comprising a drive shaft and two turntables, the two turntables are respectively disposed adjacent to the two ends of the drive shaft, and The two ends of the driving shaft are respectively connected to the two sets of power wheels, and the two rotating wheels are respectively provided with a set of driven wheels, the power wheel can drive the driven wheels to rotate; and at least one receiving member is rotatably It is disposed between the two turntables and is combined with the driven wheel. 2. According to the biomedical homogenization device described in claim 1, wherein each group of power trains is formed by two power wheels of the same number of teeth, and each group of driven wheels is composed of two identical teeth. The moving wheel is composed. 3. The biomedical homogenizing device according to claim 1 or 2, wherein the two ends of the driving shaft respectively penetrate the two sets of power wheels, and a power source is disposed at one end of the driving shaft. 4. The biomedical homogenizing device according to claim 1 or 2, wherein the driven wheel train has a rotating portion and a set of connecting portions, and the rotating portion is rotatable relative to the rotating portion, and the connecting portion is provided On the inner surface of the turntable, the set of joints is assembled for the receiving member, and the receiving member is restricted between the two turntables. 5. The biomedical homogenization device according to item 4 of the patent application scope, wherein 'the two turntables are not provided with the array wheel at the place where the driven wheel is not provided'. 14 - (10) October 20 曰 revised replacement group The connector can be rotated relative to the dial. According to the biomedical homogenization device described in item 5 of the patent application scope, the one end of the component is secretly connected to the assembly part of the driven wheel, and the other end of the i &quot; fitting is biased to the assembly of the hybrid. :: Please refer to the patent scope "f' described in the item 2'. The butterfly wall is provided with a magnetic member that is coated on the outer peripheral wall of the drive shaft to provide a magnetic force. Range 1 or 2 The biomedical homogenization device, the internal gas setting TM gas circulation component, the Kawasaki seat 9 according to the application (4) 1 or 2 of the biomedical average 10 f 'the two charms of the thief silk shaft two The end of each of the 'clamping joints, and is secured by a buckle. The biomedical homogenizing device of the second or second item of the patent scope, the housing member is divided into a plurality of pockets, the number of pockets The cover is assembled on the periphery of the accommodating member. 15 M421503 October 20, 100, revised and replaced, the designated representative map: (1) The representative representative of the case is: (1) Fig. 2 shows the symbol of the symbol of the representative figure: 1 seat 11 power wheel 2 rotating component 21 drive shaft 211 snap joint 212 snap ring 213 magnetic member 22 turntable 221 assembly 23 driven wheel 231 rotating part 232 group Connecting portion 24 linking member 3 accommodating member 31 assembling hole Μ Force source
TW100218889U 2011-10-03 2011-10-07 Biomedical homogenizer TWM421503U (en)

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