TWI869913B - 吡啶并[4,3-d]嘧啶化合物 - Google Patents

吡啶并[4,3-d]嘧啶化合物 Download PDF

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Publication number
TWI869913B
TWI869913B TW112124839A TW112124839A TWI869913B TW I869913 B TWI869913 B TW I869913B TW 112124839 A TW112124839 A TW 112124839A TW 112124839 A TW112124839 A TW 112124839A TW I869913 B TWI869913 B TW I869913B
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Taiwan
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compound
pharmaceutically acceptable
acceptable salt
tautomer
hydrate
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TW112124839A
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English (en)
Chinese (zh)
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TW202409047A (zh
Inventor
賈可伯 柯爾 迪佛瑞斯特
永田麻子
賽門 保羅 普藍肯
吉里安 艾里斯 史潘格勒
史考特 強寧 蘇頓
約翰 哈瓦德 塔拉克
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美商輝瑞大藥廠
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/16Peri-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW112124839A 2022-07-05 2023-07-04 吡啶并[4,3-d]嘧啶化合物 TWI869913B (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US202263358324P 2022-07-05 2022-07-05
US63/358,324 2022-07-05
US202263394338P 2022-08-02 2022-08-02
US63/394,338 2022-08-02
US202263414939P 2022-10-11 2022-10-11
US63/414,939 2022-10-11
US202363502931P 2023-05-18 2023-05-18
US63/502,931 2023-05-18

Publications (2)

Publication Number Publication Date
TW202409047A TW202409047A (zh) 2024-03-01
TWI869913B true TWI869913B (zh) 2025-01-11

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TW113147938A TW202513571A (zh) 2022-07-05 2023-07-04 吡啶并[4,3-d]嘧啶化合物
TW112124839A TWI869913B (zh) 2022-07-05 2023-07-04 吡啶并[4,3-d]嘧啶化合物

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EP (1) EP4551296A1 (enExample)
JP (1) JP2025525406A (enExample)
KR (1) KR20250029954A (enExample)
CN (1) CN119585286A (enExample)
AU (1) AU2023302139A1 (enExample)
CA (1) CA3261000A1 (enExample)
CL (1) CL2024003699A1 (enExample)
CO (1) CO2024016875A2 (enExample)
CR (1) CR20240556A (enExample)
DO (1) DOP2024000275A (enExample)
IL (1) IL317957A (enExample)
MA (1) MA71388A (enExample)
MX (1) MX2024015001A (enExample)
PE (1) PE20250259A1 (enExample)
TW (2) TW202513571A (enExample)
WO (1) WO2024009191A1 (enExample)

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TW202434606A (zh) * 2022-11-17 2024-09-01 大陸商江蘇恆瑞醫藥股份有限公司 稠合三環類化合物、其製備方法及其在醫藥上的應用
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KR20250164828A (ko) 2023-03-30 2025-11-25 레볼루션 메디슨즈, 인크. Ras gtp 가수분해 유도를 위한 조성물 및 이의 용도
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WO2025034702A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Rmc-6291 for use in the treatment of ras protein-related disease or disorder
WO2025054530A1 (en) 2023-09-08 2025-03-13 Gilead Sciences, Inc. Pyrimidine-containing polycyclic derivatives as kras g12d modulating compounds
WO2025080946A2 (en) 2023-10-12 2025-04-17 Revolution Medicines, Inc. Ras inhibitors
WO2025085748A1 (en) 2023-10-20 2025-04-24 Merck Sharp & Dohme Llc Small molecule inhibitors of kras proteins
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WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
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WO2024009191A1 (en) 2024-01-11
CR20240556A (es) 2025-01-29
CL2024003699A1 (es) 2025-04-11
JP2025525406A (ja) 2025-08-05
DOP2024000275A (es) 2025-01-31
IL317957A (en) 2025-02-01
KR20250029954A (ko) 2025-03-05
MX2024015001A (es) 2025-01-09
CA3261000A1 (en) 2024-01-11
PE20250259A1 (es) 2025-01-29
TW202513571A (zh) 2025-04-01
CN119585286A (zh) 2025-03-07
MA71388A (fr) 2025-04-30
CO2024016875A2 (es) 2024-12-19
EP4551296A1 (en) 2025-05-14
AU2023302139A1 (en) 2024-12-19
TW202409047A (zh) 2024-03-01

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