TWI860294B - 針對ｓｔｅａｐ１的嵌合受體及其使用方法 - Google Patents

針對ｓｔｅａｐ１的嵌合受體及其使用方法 Download PDF

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TWI860294B
TWI860294B TW108125431A TW108125431A TWI860294B TW I860294 B TWI860294 B TW I860294B TW 108125431 A TW108125431 A TW 108125431A TW 108125431 A TW108125431 A TW 108125431A TW I860294 B TWI860294 B TW I860294B
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seq
cell
cells
sequence
vector
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TW108125431A
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TW202019464A (zh
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史提沃斯 奧利維爾 諾蘭
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美商安進公司
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4274—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; Prostatic acid phosphatase [PAP]; Prostate-specific G-protein-coupled receptor [PSGR]
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    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
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TW108125431A 2018-07-18 2019-07-18 針對ｓｔｅａｐ１的嵌合受體及其使用方法 TWI860294B (zh)

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US201862700178P 2018-07-18 2018-07-18
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TW113144512A TWI902538B (zh) 2018-07-18 2019-07-18 針對steap1的嵌合受體及其使用方法

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FI3817770T3 (fi) * 2018-07-02 2026-07-06 Amgen Inc Antigeeniä sitova anti-steap1-proteiini
EP4433512A4 (en) * 2021-11-19 2025-12-31 Univ Pennsylvania Genetically modified pan-leukocyte-specific CD45 antigen to facilitate T-lymphocyte therapy
EP4476267A4 (en) * 2022-02-11 2026-01-07 Fred Hutchinson Cancer Center CHIMERIC ANTIGENIC RECEPTORS BINDING TO STEAP1
GB202208119D0 (en) * 2022-06-01 2022-07-13 Univ Oslo Hf Anti-steap1 car
CN116178532B (zh) * 2023-01-30 2025-04-04 中国科学院武汉病毒研究所 一种古尔图病毒核蛋白的单克隆抗体及其应用
AU2024274301A1 (en) * 2023-05-16 2025-12-11 Fred Hutchinson Cancer Center Pro-inflammatory cytokine enhanced steap1 recombinant receptors
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