TWI826463B - 稠合噻吩化合物 - Google Patents

稠合噻吩化合物 Download PDF

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Publication number
TWI826463B
TWI826463B TW108120511A TW108120511A TWI826463B TW I826463 B TWI826463 B TW I826463B TW 108120511 A TW108120511 A TW 108120511A TW 108120511 A TW108120511 A TW 108120511A TW I826463 B TWI826463 B TW I826463B
Authority
TW
Taiwan
Prior art keywords
group
compound
alkyl
pharmaceutically acceptable
mmol
Prior art date
Application number
TW108120511A
Other languages
English (en)
Chinese (zh)
Other versions
TW202000674A (zh
Inventor
凱爾 W H 程
阿帕瑞吉塔 荷斯可特 克瑞西亞
保羅 E 艾德曼
黎 方
法蘭克 默庫里歐
羅伯特 蘇利文
Original Assignee
美商拜歐斯瑞克斯公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 美商拜歐斯瑞克斯公司 filed Critical 美商拜歐斯瑞克斯公司
Publication of TW202000674A publication Critical patent/TW202000674A/zh
Application granted granted Critical
Publication of TWI826463B publication Critical patent/TWI826463B/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
TW108120511A 2018-06-13 2019-06-13 稠合噻吩化合物 TWI826463B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862684495P 2018-06-13 2018-06-13
US62/684,495 2018-06-13

Publications (2)

Publication Number Publication Date
TW202000674A TW202000674A (zh) 2020-01-01
TWI826463B true TWI826463B (zh) 2023-12-21

Family

ID=67263033

Family Applications (1)

Application Number Title Priority Date Filing Date
TW108120511A TWI826463B (zh) 2018-06-13 2019-06-13 稠合噻吩化合物

Country Status (8)

Country Link
US (2) US11191769B2 (enExample)
EP (1) EP3807283A1 (enExample)
JP (1) JP7365059B2 (enExample)
CN (1) CN112601751B (enExample)
AU (1) AU2019284605A1 (enExample)
CA (1) CA3101335C (enExample)
TW (1) TWI826463B (enExample)
WO (1) WO2019241271A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10513515B2 (en) * 2017-08-25 2019-12-24 Biotheryx, Inc. Ether compounds and uses thereof
JP7629459B2 (ja) 2019-11-19 2025-02-13 ブリストル－マイヤーズ スクイブ カンパニー Ｈｅｌｉｏｓタンパク質の阻害剤として有用な化合物
WO2021155050A1 (en) * 2020-01-29 2021-08-05 Biotheryx, Inc. Kinase modulators, pharmaceutical compositions, and therapeutic applications
TW202140441A (zh) 2020-03-23 2021-11-01 美商必治妥美雅史谷比公司 經取代之側氧基異吲哚啉化合物
US20240025863A1 (en) 2020-09-16 2024-01-25 Biotheryx, Inc. Sos1 protein degraders, pharmaceutical compositions thereof, and their therapeutic applications
CN122562781A (zh) * 2020-10-07 2026-08-14 上海睿跃生物科技有限公司 治疗癌症的化合物和方法
TW202231269A (zh) 2020-10-23 2022-08-16 美商拜歐斯瑞克斯公司 Kras蛋白降解劑、其醫藥組合物及其治療應用
US20240124418A1 (en) 2020-12-14 2024-04-18 Biotheryx, Inc. Pde4 degraders, pharmaceutical compositions, and therapeutic applications
CN117242060B (zh) 2021-01-13 2026-07-17 蒙特罗莎治疗股份有限公司 异吲哚啉酮化合物
PE20231941A1 (es) 2021-04-06 2023-12-05 Bristol Myers Squibb Co Compuestos de oxoisoindolina sustituidos con piridinilo
WO2023069731A1 (en) * 2021-10-22 2023-04-27 Monte Rosa Therapeutics, Inc. Compounds that mediate protein degradation and methods of use thereof
US12419962B2 (en) 2022-03-16 2025-09-23 Biotheryx, Inc. Quinazolines, pharmaceutical compositions, and therapeutic applications
US12662467B2 (en) 2022-04-18 2026-06-23 BioThery X, Inc. Isoindolinones, pharmaceutical compositions, and therapeutic applications
EP4554581A1 (en) 2022-07-13 2025-05-21 Monte Rosa Therapeutics AG Combination therapy comprising gspt1-directed molecular glue degraders and pi3k/akt/mtor pathway inhibitors
JP2025531869A (ja) 2022-09-09 2025-09-25 イノヴォ セラピューティクス、インコーポレイテッド ＣＫ１αおよびＤＵＡＬ ＣＫ１α／ＧＳＰＴ１分解化合物
WO2024222918A1 (zh) * 2023-04-28 2024-10-31 中国药科大学 一种苯并六元杂环类gspt1蛋白降解剂及其应用
CN119371398A (zh) * 2023-07-25 2025-01-28 安道麦阿甘有限公司 用于制备噻吩酮的新路线
WO2025179161A1 (en) 2024-02-21 2025-08-28 Innovo Therapeutics, Inc. Protein degrading compounds

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1964842A1 (en) * 2005-09-27 2008-09-03 Tian Jin Hemay Bio-Tech Co., Ltd. 5H-THIENO [3,4-c]PYRROLE-4, 6-DIONE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR
EP2093228B1 (en) * 2006-11-15 2012-02-22 Tianjin Hemay Bio-Tech Co., Ltd. Pyrroline-2-one derivatives against cell releasing tumor necrosis factor, preparation methods and uses thereof
WO2016191178A1 (en) * 2015-05-22 2016-12-01 Biotheryx, Inc. Compounds targeting proteins, compositions, methods, and uses thereof
TWI756957B (zh) * 2016-12-21 2022-03-01 美商拜歐斯瑞克斯公司 靶向蛋白質之化合物、組合物、方法及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015305449B2 (en) 2014-08-22 2021-05-06 Celgene Corporation Methods of treating multiple myeloma with immunomodulatory compounds in combination with antibodies

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1964842A1 (en) * 2005-09-27 2008-09-03 Tian Jin Hemay Bio-Tech Co., Ltd. 5H-THIENO [3,4-c]PYRROLE-4, 6-DIONE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR
EP2093228B1 (en) * 2006-11-15 2012-02-22 Tianjin Hemay Bio-Tech Co., Ltd. Pyrroline-2-one derivatives against cell releasing tumor necrosis factor, preparation methods and uses thereof
WO2016191178A1 (en) * 2015-05-22 2016-12-01 Biotheryx, Inc. Compounds targeting proteins, compositions, methods, and uses thereof
TWI756957B (zh) * 2016-12-21 2022-03-01 美商拜歐斯瑞克斯公司 靶向蛋白質之化合物、組合物、方法及其用途

Also Published As

Publication number Publication date
US20220088025A1 (en) 2022-03-24
JP7365059B2 (ja) 2023-10-19
TW202000674A (zh) 2020-01-01
US11191769B2 (en) 2021-12-07
CA3101335A1 (en) 2019-12-19
WO2019241271A1 (en) 2019-12-19
CA3101335C (en) 2024-01-09
CN112601751B (zh) 2024-04-02
JP2021527098A (ja) 2021-10-11
CN112601751A (zh) 2021-04-02
AU2019284605A1 (en) 2020-12-10
US20200000814A1 (en) 2020-01-02
EP3807283A1 (en) 2021-04-21

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