TWI825029B - 針對突變ras之hla第ii類限制性t細胞受體 - Google Patents

針對突變ras之hla第ii類限制性t細胞受體 Download PDF

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TWI825029B
TWI825029B TW107133221A TW107133221A TWI825029B TW I825029 B TWI825029 B TW I825029B TW 107133221 A TW107133221 A TW 107133221A TW 107133221 A TW107133221 A TW 107133221A TW I825029 B TWI825029 B TW I825029B
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TW201920251A (zh
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拉彌 約瑟夫
蓋爾 卡夫利
保羅 Ｆ 羅賓斯
史帝文 Ａ 羅森伯格
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美國衛生與公眾服務部
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TW107133221A 2017-09-20 2018-09-20 針對突變ras之hla第ii類限制性t細胞受體 TWI825029B (zh)

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US201762560930P 2017-09-20 2017-09-20
US62/560,930 2017-09-20

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TW201920251A TW201920251A (zh) 2019-06-01
TWI825029B true TWI825029B (zh) 2023-12-11

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US (3) US11306132B2 (https=)
EP (1) EP3684799A1 (https=)
JP (1) JP7256794B2 (https=)
KR (2) KR102777370B1 (https=)
CN (2) CN120082603A (https=)
AR (1) AR112902A1 (https=)
AU (2) AU2018335274B2 (https=)
BR (1) BR112020005469A2 (https=)
CA (1) CA3076339A1 (https=)
CR (1) CR20240019A (https=)
EA (1) EA202090652A1 (https=)
IL (1) IL273254B2 (https=)
MA (1) MA50180A (https=)
MX (2) MX2020003117A (https=)
SG (1) SG11202002425PA (https=)
TW (1) TWI825029B (https=)
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GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
KR20210119468A (ko) * 2019-01-25 2021-10-05 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 돌연변이체 ras를 표적화하기 위한 조성물 및 방법
CN112759641B (zh) * 2019-11-01 2023-01-20 香雪生命科学技术（广东）有限公司 一种识别Kras G12V的高亲和力TCR
WO2021123832A1 (en) 2019-12-20 2021-06-24 Instil Bio (Uk) Limited Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof
AU2021220957A1 (en) * 2020-02-14 2022-09-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services HLA class I-restricted T cell receptors against ras with G12V mutation
US20230100941A1 (en) * 2020-02-19 2023-03-30 Aelin Therapeutics Molecules targeting mutant ras protein
TWI900533B (zh) * 2020-02-26 2025-10-11 美國衛生與公眾服務部 針對含有ｇ１２ｖ突變之ｒａｓ之ｈｌａ第ｉｉ類限制性ｔ細胞受體
WO2021262829A2 (en) * 2020-06-24 2021-12-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hla class i-restricted t cell receptors against cd20
WO2022015694A1 (en) * 2020-07-13 2022-01-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hla class ii–restricted drb t cell receptors against ras with g12d mutation
CN116348484A (zh) * 2020-07-16 2023-06-27 美国卫生和人力服务部 针对含有g12v突变的ras的hla-ii类限制性drb t细胞受体
CN112300269B (zh) * 2020-09-29 2022-12-09 中国科学院微生物研究所 Kras突变特异性t细胞受体筛选及抗肿瘤用途
TW202540156A (zh) * 2020-10-02 2025-10-16 美國衛生與公眾服務部 針對含有g13d突變之ras之hla第ii類限制性dq t細胞受體
US20240000834A1 (en) * 2020-11-24 2024-01-04 Shanghai GenBase Biotechnology Co., Ltd. Ras mutant epitope peptide and t cell receptor recognizing ras mutant
IL305393A (en) 2021-02-25 2023-10-01 Alaunos Therapeutics Inc Recombinant vectors comprising polycistronic expression cassettes and methods of use thereof
US20250145950A1 (en) 2022-02-01 2025-05-08 Alaunos Therapeutics, Inc. Methods for Activation and Expansion of T Cells
CN114835800B (zh) * 2022-05-27 2023-10-13 重庆医科大学 Tcr或其抗原结合片段及其应用
CN117264043B (zh) * 2022-06-14 2024-05-10 上海镔铁生物科技有限责任公司 靶向kras g12v突变多肽的t细胞受体及其用途
US20240325448A1 (en) * 2022-09-29 2024-10-03 Jerome Canady Research Institute for Advanced Biological and Technological Sciences Cold atmopsheric plasma treated pan-cancer epitope peptide within the collagen type vi a-3 (col6a3) protein as cancer vaccine
WO2026019786A1 (en) * 2024-07-16 2026-01-22 Board Of Regents, The University Of Texas System Peptides and engineered t cell receptors targeting brachyury antigen and methods of use
WO2026024602A2 (en) * 2024-07-22 2026-01-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors against ras with g12d, g12v, g13d or q61r mutation

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WO2017048593A1 (en) * 2015-09-15 2017-03-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors recognizing hla-cw8 restricted mutated kras

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IL273254A (en) 2020-04-30
CR20240019A (es) 2024-02-15
CN111201237A (zh) 2020-05-26
KR102777370B1 (ko) 2025-03-10
US20190085046A1 (en) 2019-03-21
MA50180A (fr) 2021-05-26
CN120082603A (zh) 2025-06-03
IL273254B1 (en) 2024-05-01
WO2019060349A1 (en) 2019-03-28
BR112020005469A2 (pt) 2020-09-29
IL273254B2 (en) 2024-09-01
MX2020003117A (es) 2020-08-20
CA3076339A1 (en) 2019-03-28
JP7256794B2 (ja) 2023-04-12
AU2018335274A1 (en) 2020-04-09
US20250250318A1 (en) 2025-08-07
US12304940B2 (en) 2025-05-20
SG11202002425PA (en) 2020-04-29
AU2025202532A1 (en) 2025-05-01
EP3684799A1 (en) 2020-07-29
KR20200051804A (ko) 2020-05-13
US20220204584A1 (en) 2022-06-30
MX2024004610A (es) 2024-04-30
CN111201237B (zh) 2025-03-25
AU2018335274B2 (en) 2025-02-13
KR20250037592A (ko) 2025-03-17
AU2025202532A9 (en) 2025-09-04
TW201920251A (zh) 2019-06-01
AR112902A1 (es) 2019-12-26
JP2020534828A (ja) 2020-12-03
EA202090652A1 (ru) 2020-08-21
US11306132B2 (en) 2022-04-19

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