TWI820842B - Method for detecting dynamic intraocular pressure and the system - Google Patents
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一種眼壓偵測方法及其系統,特別是涉及一種動態眼壓偵測方法及其系統。An intraocular pressure detection method and its system, particularly a dynamic intraocular pressure detection method and its system.
習知最常見的測量眼內壓方式為非接觸式壓平眼內壓計(non-contact tonometer,NCT)測量法,其利用氣體脈衝力壓平3.06mm直徑角膜中央區,因此不需要麻醉,僅需要將頭擺放於支架上,並注視儀器中的光點,此時,檢查者由非接觸式壓平眼內壓計之目鏡中瞄準患者眼睛後,按下發射鈕,發出的脈衝氣流而可壓平角膜,在此過程中,眼角膜表面因受力而從凸起變形至平坦,再到凹陷,並隨著力量的減弱,漸漸地由凹陷至平坦,最後回復至原本的形狀,透過發射紅外線以偵測角膜反射光的能量,來推測得知角膜的凹陷程度,不同的曲率使得紅外線的反射角度也會有所不同,儀器接收紅外線訊號最強的時間點定為壓平點,並且將第一個壓平點的吹氣壓力定為眼內壓,如此一來,即可顯示眼內壓值,通常連續2-3次後,取其平均值。The most common way to measure intraocular pressure is the non-contact tonometer (NCT) measurement method, which uses gas pulse force to flatten the central area of the cornea with a diameter of 3.06mm, so it does not require anesthesia. You only need to place your head on the stand and look at the light spot in the instrument. At this time, the examiner aims at the patient's eyes through the eyepiece of the non-contact applanation intraocular pressure meter, presses the launch button, and emits a pulse of airflow. It can flatten the cornea. During this process, the surface of the cornea deforms from convex to flat to concave due to force. As the force weakens, it gradually changes from concave to flat, and finally returns to its original shape. By emitting infrared rays to detect the energy of light reflected from the cornea, we can infer the degree of cornea sunkenness. Different curvatures will cause different reflection angles of infrared rays. The time point when the instrument receives the strongest infrared ray signal is designated as the applanation point, and The insufflation pressure at the first flattening point is determined as the intraocular pressure. In this way, the intraocular pressure value can be displayed. Usually, after 2-3 consecutive times, the average value is taken.
前述非接觸式壓平眼內壓計雖稱非接觸式,惟尚需發出脈衝氣流以壓平角膜,此一動作,經常使得患者不自覺眨眼,更甚者有些患者本身因眼睛有發炎、乾眼症或其他症狀導致頻繁性的眨眼,如此一來,更難得以此測量方式測得其眼內壓,且,一般眼壓之檢測,需要一段時間於不移動眼球的情況下進行檢測,因此眼壓檢測裝置內設有一圖形以供使用者觀看,並且固定其眼球位置,惟其測量時間頗長,若檢測對象為幼童時,將增加其檢測的困難度,為此,本發明提供一種動態眼壓偵測方法及其系統,其以擷取單元進行測量,僅擷取兩種不同狀態下的眼球變形量,並以兩者不同情形下的變形量換算出眼內壓,而不需要於特別靜止狀態進行檢測,只要可以擷取到眼球不同狀態下的變形量即可,亦完全不需要接觸眼球,大幅改善習知須以脈衝氣流接觸眼睛的不適感,以及降低檢測的困難度,亦增加其精準度。Although the aforementioned non-contact applanation intraocular pressure meter is called non-contact, it still needs to emit pulsed airflow to flatten the cornea. This action often causes patients to blink unconsciously. What's more, some patients have inflammation and dry eyes. Ophthalmia or other symptoms lead to frequent blinking, which makes it more difficult to measure intraocular pressure with this measurement method. Moreover, the detection of intraocular pressure generally requires a period of time without moving the eyeballs. Therefore, The intraocular pressure detection device is provided with a pattern for the user to view and fix the position of the eyeball. However, the measurement time is quite long. If the detection object is a young child, the difficulty of the detection will increase. To this end, the present invention provides a dynamic Intraocular pressure detection method and its system, which uses a capture unit to measure, only captures the deformation amount of the eyeball in two different states, and converts the intraocular pressure based on the deformation amount in the two different situations, without requiring The detection is carried out in a special static state, as long as the deformation amount of the eyeball in different states can be captured, and there is no need to contact the eyeball, which greatly improves the discomfort of the conventional eye contact with pulse airflow and reduces the difficulty of detection. Increase its accuracy.
本發明之主要目的,係提供一種動態眼壓偵測方法,其以擷取單元於不同狀態下分別擷取對應眼球之狀態資訊,並以推算其眼球變形量,依據不同的變形量取得動態眼壓值,而不須另以脈衝氣流於眼球形成凹陷,亦不需要特別靜止,大幅降低檢測困難度。The main purpose of the present invention is to provide a dynamic intraocular pressure detection method, which uses an acquisition unit to respectively acquire the state information of the corresponding eyeball in different states, and calculates the amount of eyeball deformation, and obtains dynamic eye pressure based on different deformation amounts. The pressure value does not need to be pulsated airflow to form a depression in the eyeball, nor does it need to be particularly still, which greatly reduces the difficulty of detection.
本發明之另一目的,係提供一種動態眼壓偵測系統,其係以運算處理單元接收擷取單元取得眼球之狀態資訊,並透過不同的狀態資訊取得動態眼壓值,以提升精確度。Another object of the present invention is to provide a dynamic intraocular pressure detection system that uses a processing unit to receive and acquire the eyeball's status information, and obtains dynamic intraocular pressure values through different status information to improve accuracy.
為了達到上述之目的,本發明之一實施例係揭示動態眼壓偵測方法,包含步驟: 以一擷取單元擷取並傳輸一眼球之一第一狀態資訊至一運算處理單元;以該擷取單元擷取並傳輸該眼球之一第二狀態資訊至該運算處理單元;及該運算處理單元依據該第一狀態資訊及該第二狀態資訊進行運算,生成對應之一動態眼壓值。In order to achieve the above object, one embodiment of the present invention discloses a dynamic intraocular pressure detection method, including the steps of: using an acquisition unit to acquire and transmit first status information of an eyeball to a computing unit; using the acquisition unit The acquisition unit acquires and transmits a second state information of the eyeball to the computing and processing unit; and the computing and processing unit performs operations based on the first state information and the second state information to generate a corresponding dynamic intraocular pressure value.
較佳地,於以一擷取單元擷取並傳輸一眼球之一第一狀態資訊至一運算處理單元之步驟中,更包含步驟:以該擷取單元於一第一狀態之一第一時間發射一第一光源至該眼球,並接收於該眼球反射之該第一光源之一第一反射時間,以及該擷取單元於該第一狀態之一第二時間發射一第二光源至該眼球,並接收於該眼球反射之該第二光源之一第二反射時間,該第一狀態資訊係包含該第一反射時間及該第二反射時間;該運算處理單元分別依據該第一反射時間及該第二反射時間,取得對應於該眼球之一第一深度及一第二深度;該運算處理單元分別依據該第一深度及該第二深度進行運算,生成一第一表面積及一第二表面積;及該運算處理單元依據該第一表面積與該第二表面積之比例,以擷取對應該第一狀態之該眼球之該第一變形量。Preferably, the step of using a capturing unit to capture and transmit the first state information of an eyeball to a computing processing unit further includes the step of using the capturing unit to capture a first state information at a first time Emit a first light source to the eyeball, and receive a first reflection time of the first light source reflected by the eyeball, and the capture unit emits a second light source to the eyeball at a second time in the first state. , and receives a second reflection time of the second light source reflected by the eyeball, the first state information includes the first reflection time and the second reflection time; the computing unit performs the processing according to the first reflection time and the second reflection time respectively. The second reflection time obtains a first depth and a second depth corresponding to the eyeball; the computing unit performs calculations based on the first depth and the second depth respectively to generate a first surface area and a second surface area. ; and the computing unit obtains the first deformation amount of the eyeball corresponding to the first state based on the ratio of the first surface area to the second surface area.
較佳地,於該運算處理單元分別依據該第一反射時間及該第二反射時間,取得對應於該眼球之一第一深度及一第二深度之步驟中,該第一深度為該第一反射時間與光速之乘積,以及該第二深度為該第二反射時間與光速之乘積。Preferably, in the step of the computing unit obtaining a first depth and a second depth corresponding to the eyeball based on the first reflection time and the second reflection time, the first depth is the first depth. The product of the reflection time and the speed of light, and the second depth is the product of the second reflection time and the speed of light.
較佳地,於該運算處理單元分別依據該第一深度及該第二深度進行運算,生成一第一表面積及一第二表面積之步驟中,更包含步驟: 該運算處理單元依據該第一深度生成對應之一第一座標值,以及該第二深度生成對應之一第二座標值;及該運算處理單元依據該第一座標值及一第一演算法進行演算,取得該第一表面積,以及依據第二座標值及該第一演算法進行演算,取得該第二表面積;其中,該第一演算法為曲面積分。Preferably, in the step of the computing processing unit performing operations based on the first depth and the second depth respectively to generate a first surface area and a second surface area, the step further includes the step: the computing processing unit performs operations based on the first depth Generate a corresponding first coordinate value, and generate a corresponding second coordinate value for the second depth; and the computing unit performs calculations based on the first coordinate value and a first algorithm to obtain the first surface area, and Calculation is performed based on the second coordinate value and the first algorithm to obtain the second surface area; wherein the first algorithm is surface integral.
較佳地,於以該擷取單元擷取並傳輸該眼球之一第二狀態資訊至該運算處理單元之步驟中,更包含步驟: 以該擷取單元於一第二狀態之一第三時間發射一第三光源至該眼球,並接收於該眼球反射之該第三光源之一第三反射時間,以及該擷取單元於該第二狀態之一第四時間發射一第四光源至該眼球,並接收於該眼球反射之該第四光源之一第四反射時間,該第二狀態資訊係包含該第三反射時間及該第四反射時間;該運算處理單元分別依據該第三反射時間及該第四反射時間,取得對應於該眼球之一第三深度及一第四深度;該運算處理單元分別依據該第三深度及該第四深度進行運算,生成一第三表面積及一第四表面積;及該運算處理單元依據該第三表面積與該第四表面積之比例,以擷取對應該第二狀態之該眼球之該第二變形量。Preferably, the step of using the capturing unit to capture and transmit a second state information of the eyeball to the computing processing unit further includes the step of: using the capturing unit to capture a second state information at a third time Emit a third light source to the eyeball, and receive a third reflection time of the third light source reflected by the eyeball, and the capture unit emits a fourth light source to the eyeball at a fourth time in the second state. , and receives a fourth reflection time of the fourth light source reflected by the eyeball, the second state information includes the third reflection time and the fourth reflection time; the computing unit respectively performs the processing according to the third reflection time and the fourth reflection time. The fourth reflection time obtains a third depth and a fourth depth corresponding to the eyeball; the computing unit performs calculations based on the third depth and the fourth depth respectively to generate a third surface area and a fourth surface area. ; and the processing unit obtains the second deformation amount of the eyeball corresponding to the second state based on the ratio of the third surface area to the fourth surface area.
較佳地,於該運算處理單元分別依據該第三反射時間及該第四反射時間,取得對應於該眼球之一第三深度及一第四深度之步驟中,該第三深度為該第三反射時間與光速之乘積,以及該第四深度為該第四反射時間與光速之乘積。Preferably, in the step of the processing unit obtaining a third depth and a fourth depth corresponding to the eyeball based on the third reflection time and the fourth reflection time respectively, the third depth is the third depth. The product of the reflection time and the speed of light, and the fourth depth is the product of the fourth reflection time and the speed of light.
較佳地,於該運算處理單元分別依據該第三深度及該第四深度進行運算,生成一第三表面積及一第四表面積之步驟中,更包含步驟: 該運算處理單元依據該第三深度生成對應之一第三座標值,以及該第四深度生成對應之一第四座標值;及該運算處理單元依據該第三座標值與一第二演算法進行演算,取得該第三表面積,以及該第四座標值與該第二演算法進行演算,取得該第四表面積; 其中,該第二演算法為曲面積分。Preferably, in the step of the arithmetic processing unit performing operations based on the third depth and the fourth depth respectively to generate a third surface area and a fourth surface area, the step further includes the step: the arithmetic processing unit performs operations based on the third depth Generate a corresponding third coordinate value, and generate a corresponding fourth coordinate value for the fourth depth; and the computing unit performs calculations based on the third coordinate value and a second algorithm to obtain the third surface area, and The fourth coordinate value is calculated with the second algorithm to obtain the fourth surface area; wherein the second algorithm is surface integral.
較佳地,擷取單元包含一紅外線影像感測器。Preferably, the capturing unit includes an infrared image sensor.
為了達到上述之另一目的,本發明之一實施例係揭示動態眼壓偵測系統,包含: 一擷取單元,於一眼球之一第一狀態擷取該眼球對應之一第一狀態資訊,及於該眼球之一第二狀態擷取該眼球對應之一第二狀態資訊;及一運算處理單元,與擷取單元訊號連接,用以接收並依據該第一狀態資訊及該第二狀態資訊進行運算,取得一動態眼壓值。In order to achieve another of the above objects, one embodiment of the present invention discloses a dynamic intraocular pressure detection system, including: an acquisition unit that acquires first state information corresponding to an eyeball in a first state of the eyeball, and capturing a second state information corresponding to the eyeball in a second state of the eyeball; and a computing processing unit, signal-connected to the capturing unit, for receiving and based on the first state information and the second state information. Perform calculations to obtain a dynamic intraocular pressure value.
較佳地,該擷取單元包含一紅外線影像感測器。Preferably, the capturing unit includes an infrared image sensor.
本發明之有益功效在於以擷取單元於兩種不同狀態下分別檢測眼球之狀態資訊,並經由運算處理單元推算出眼球之變形量,再將兩者不同的變形量轉換為動態眼壓值,實現不接觸之眼球檢測方法,提升測量精準度,且,不需要任何注視特定位置,降低檢測困難度。The beneficial effect of the present invention is that the acquisition unit detects the state information of the eyeball in two different states, and calculates the deformation amount of the eyeball through the computing unit, and then converts the two different deformation amounts into dynamic intraocular pressure values. It implements a non-contact eyeball detection method to improve measurement accuracy, and does not require any attention to a specific position, reducing detection difficulty.
有關本發明之相關申請專利特色與技術內容,在以下配合參考圖式之較佳實施例的詳細說明中,將可清楚的呈現。The relevant patented features and technical content of the present invention will be clearly presented in the following detailed description of the preferred embodiments with reference to the drawings.
請參閱第1圖,為本發明之一實施例之系統作動示意圖。如圖所示,本發明之一種動態眼壓偵測系統,包含:擷取單元1及運算處理單元2,其中,擷取單元1係與運算處理單元2訊號連接。Please refer to Figure 1, which is a schematic diagram of system operation according to an embodiment of the present invention. As shown in the figure, a dynamic intraocular pressure detection system of the present invention includes: an acquisition unit 1 and a processing unit 2, wherein the acquisition unit 1 is connected with the operation processing unit 2 through signals.
請一併參閱第2圖,其為本發明之一實施例之方法流程圖。如圖所示,本發明之一種動態眼壓偵測方法包含下列步驟:Please also refer to Figure 2, which is a method flow chart according to an embodiment of the present invention. As shown in the figure, a dynamic intraocular pressure detection method of the present invention includes the following steps:
步驟S1: 以一擷取單元擷取並傳輸一眼球之一第一狀態資訊至一運算處理單元;Step S1: Use an acquisition unit to acquire and transmit the first status information of an eyeball to a computing processing unit;
步驟S3: 以該擷取單元擷取並傳輸該眼球之一第二狀態資訊至該運算處理單元;及Step S3: Use the acquisition unit to acquire and transmit a second state information of the eyeball to the computing processing unit; and
步驟S5: 該運算處理單元依據該第一狀態資訊及該第二狀態資訊進行運算,生成對應之一動態眼壓值。Step S5: The calculation processing unit performs calculations based on the first status information and the second status information to generate a corresponding dynamic intraocular pressure value.
如步驟S1所示,擷取單元1係於眼球之第一狀態之第一時間發射第一光源至眼球,並接收於眼球所反射之第一光源之第一反射時間,接續係於眼球之第一狀態之第二時間發射第二光源至眼球,並接收於眼球所反射之第二光源之第二反射時間,為此,第一狀態資訊係包含第一反射時間及第二反射時間,於一實施中,第一狀態並不限制於靜止情形,其中,第一時間與第二時間係皆於第一狀態的情況下發射光源,且,第一時間與第二時間不相同,藉以推導出其眼球變形量,但不在此限,運算處理單元2可分別以第一反射時間與光速之乘積取得第一深度,及以第二反射時間與光速之乘積取得第二深度,其中,光速為指光在真空中的速率,其為一個物理常數,精確值為299,792,458m/s,本實施例則以3×10 8m/s作為運算,但不在此限。 As shown in step S1, the capture unit 1 emits the first light source to the eyeball at the first time in the first state of the eyeball, and receives the first reflection time of the first light source reflected by the eyeball, and then the first light source is received at the first reflection time of the eyeball. A second light source is emitted to the eyeball at a second time in a state, and a second reflection time of the second light source reflected by the eyeball is received. For this reason, the first state information includes the first reflection time and the second reflection time, in a In implementation, the first state is not limited to a stationary situation. The first time and the second time are both emitting light sources in the first state, and the first time and the second time are different, so as to deduce the The amount of eyeball deformation, but is not limited to this, the processing unit 2 can respectively obtain the first depth using the product of the first reflection time and the speed of light, and obtain the second depth using the product of the second reflection time and the speed of light, where the speed of light refers to The velocity in vacuum is a physical constant with an exact value of 299,792,458m/s. This embodiment uses 3×10 8 m/s as the calculation, but is not limited to this.
同時,依據第一深度生成對應之第一座標值,及依據第二深度生成對應之第二座標值,並以第一演算法進行演算後,分別取得第一表面積及第二表面積,於一實施例中,第一演算法可採用曲面積分,進而以第一表面積與第二表面積之比例取得第一變形量,其中,擷取單元1為紅外線影像感測器,且第一光源及第二光源皆為波長在760nm至1mm之間的紅外光。At the same time, a corresponding first coordinate value is generated based on the first depth, and a corresponding second coordinate value is generated based on the second depth, and after calculation with the first algorithm, the first surface area and the second surface area are obtained respectively, and in an implementation For example, the first algorithm can use the surface integral to obtain the first deformation amount based on the ratio of the first surface area to the second surface area, where the capture unit 1 is an infrared image sensor, and the first light source and the second light source All are infrared light with wavelengths between 760nm and 1mm.
如步驟S3所示,其與前一步驟相似,係以擷取單元1係於第二狀態之第三時間發射第三光源至眼球,並接收於眼球反射之第三光源之第三反射時間,接續係於眼球之第二狀態之第四時間發射第四光源至眼球,並接收於眼球所反射之第四光源之第四反射時間,因此第二狀態資訊係包含第三反射時間及第四反射時間,其中,與前一步驟相同的是,第三時間與第四時間係皆於第二狀態的情況下發射光源,且,第三時間與第四時間不相同,其目的亦與前述步驟之目的相同,與前一步驟差異在於第二狀態與第一狀態係不相同,用以取得兩者狀態下眼球之狀態資訊差異,但不在此限,運算處理單元2可分別以第三反射時間與光速之乘積取得第三深度,及以第四反射時間與光速之乘積取得第四深度,其中,光速為指光在真空中的速率,其為一個物理常數,精確值為299,792,458m/s,本實施例則以3×10 8m/s作為運算,但不在此限。 As shown in step S3, which is similar to the previous step, the capturing unit 1 emits the third light source to the eyeball at the third time in the second state, and receives the third reflection time of the third light source reflected by the eyeball. The connection is to emit the fourth light source to the eyeball at the fourth time in the second state of the eyeball and receive the fourth reflection time of the fourth light source reflected by the eyeball. Therefore, the second state information includes the third reflection time and the fourth reflection. time, the same as the previous step is that the third time and the fourth time both emit light sources in the second state, and the third time and the fourth time are different, and their purpose is also the same as the previous step. The purpose is the same, but the difference from the previous step is that the second state is different from the first state, and is used to obtain the difference in state information of the eyeballs in the two states. However, this is not limited to this. The processing unit 2 can use the third reflection time and the first state respectively. The product of the speed of light obtains the third depth, and the product of the fourth reflection time and the speed of light obtains the fourth depth. The speed of light refers to the speed of light in a vacuum. It is a physical constant with an exact value of 299,792,458m/s. This article In the embodiment, 3×10 8 m/s is used as the operation, but it is not limited to this.
同時,依據第三深度生成對應之第三座標值,及依據第四深度生成對應之第四座標值,並以第二演算法進行演算後,分別取得第三表面積及第四表面積,於一實施例中,第二演算法可採用曲面積分,進而以第三表面積與第四表面積之比例取得第二變形量,其中,擷取單元1為紅外線影像感測器,且第三光源及第四光源皆為波長在760nm至1mm之間的紅外光。At the same time, a corresponding third coordinate value is generated based on the third depth, and a corresponding fourth coordinate value is generated based on the fourth depth, and after calculation with the second algorithm, the third surface area and the fourth surface area are obtained respectively, and in an implementation For example, the second algorithm can use the surface integral to obtain the second deformation amount based on the ratio of the third surface area and the fourth surface area, where the capture unit 1 is an infrared image sensor, and the third light source and the fourth light source All are infrared light with wavelengths between 760nm and 1mm.
如步驟S5所示,運算處理單元2依據前述取得之第一狀態資訊推算出對應之第一變形量,即眼球靜止外型,以及第二狀態資訊推算出對應之第二變形量,即轉動變形外型,故取得不同之第一變形量及第二變形量進行運算後,推估出動態應力數據,進而生成對應之動態眼壓值,此一動態眼壓值則可更精準呈現眼球之眼內壓。As shown in step S5, the processing unit 2 calculates the corresponding first deformation amount, that is, the static appearance of the eyeball, based on the first state information obtained above, and the corresponding second deformation amount, that is, the rotational deformation, based on the second state information. Therefore, after obtaining different first deformation amounts and second deformation amounts for calculation, the dynamic stress data is estimated, and then the corresponding dynamic intraocular pressure value is generated. This dynamic intraocular pressure value can more accurately represent the eyeball. internal pressure.
綜上所述,本發明之動態眼壓偵測方法及其系統,以擷取單元擷取眼球外型資訊,並採用運算處理單元進行運算後,比對眼球靜止外型與轉動變形外型。並藉由外型的差異,取得不同的變形量並推估動態應力數據,進而估算動態眼壓值。實現完全不接觸式的動態眼壓測量,除了大幅降低檢測的不適感以外,更減少測量的困難度,即便測量對象為兒童亦可輕鬆完成,亦增加量測之精準度,故確實可以達成本發明之目的。To sum up, the dynamic intraocular pressure detection method and system of the present invention use an acquisition unit to acquire eyeball appearance information, and use a computing unit to perform calculations to compare the static appearance of the eyeball with the rotationally deformed appearance. And through the difference in appearance, different deformations are obtained and the dynamic stress data is estimated, thereby estimating the dynamic intraocular pressure value. Achieving completely non-contact dynamic intraocular pressure measurement not only greatly reduces the discomfort of detection, but also reduces the difficulty of measurement. Even if the measurement object is a child, it can be easily completed. It also increases the accuracy of measurement, so it can indeed achieve this goal. purpose of invention.
惟以上所述者,僅為本發明之較佳實施例而已,當不能以此限定本發明實施之範圍,即凡依本發明申請專利範圍及發明說明內容所作之簡單的等效變化與修飾,皆仍屬本發明專利涵蓋之範圍內。However, the above are only preferred embodiments of the present invention, and should not be used to limit the scope of the present invention. That is, any simple equivalent changes and modifications made in accordance with the patent scope of the present invention and the description of the invention, All are still within the scope of the patent of this invention.
1:擷取單元 2:運算處理單元 S1:步驟 S3:步驟 S5:步驟 1: Capture unit 2:Arithmetic processing unit S1: Steps S3: Steps S5: Steps
第1圖: 其為本發明之一實施例之系統作動示意圖;及 第2圖: 其為本發明之一實施例之方法流程圖。 Figure 1: This is a schematic diagram of the system operation according to an embodiment of the present invention; and Figure 2: This is a method flow chart according to an embodiment of the present invention.
1:擷取單元 1: Capture unit
2:運算處理單元 2:Arithmetic processing unit
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