TWI808648B - 使用包含gdc-9545及gdc-0077之組合療法治療乳癌 - Google Patents
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- TWI808648B TWI808648B TW111105232A TW111105232A TWI808648B TW I808648 B TWI808648 B TW I808648B TW 111105232 A TW111105232 A TW 111105232A TW 111105232 A TW111105232 A TW 111105232A TW I808648 B TWI808648 B TW I808648B
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
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| US202163149944P | 2021-02-16 | 2021-02-16 | |
| US63/149,944 | 2021-02-16 |
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| TW202237100A TW202237100A (zh) | 2022-10-01 |
| TWI808648B true TWI808648B (zh) | 2023-07-11 |
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| PL (1) | PL4294395T3 (https=) |
| TW (1) | TWI808648B (https=) |
| WO (1) | WO2022177844A1 (https=) |
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| JP2025163068A (ja) * | 2022-11-02 | 2025-10-28 | ペトラ・ファーマ・コーポレイション | 疾患の治療のためのホスホイノシチド３－キナーゼ（ｐｉ３ｋ）のアロステリックポケット及びオルソステリックポケットの標的化 |
| KR20250107982A (ko) * | 2022-11-02 | 2025-07-14 | 페트라 파마 코포레이션 | 질환의 치료를 위한 포스포이노시티드 3-키나제 (pi3k)의 알로스테릭 및 오르토스테릭 포켓 표적화 |
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| WO2017216280A1 (en) * | 2016-06-16 | 2017-12-21 | F. Hoffmann-La Roche Ag | TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF |
| WO2020023297A1 (en) * | 2018-07-23 | 2020-01-30 | Genentech, Inc. | Methods of treating cancer with pi3k inhibitor, gdc-0077 |
| WO2020037203A2 (en) * | 2018-08-17 | 2020-02-20 | Genentech, Inc. | Diagnostic and therapeutic methods for the treatment of breast cancer |
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| KR102785474B1 (ko) | 2014-12-18 | 2025-03-26 | 에프. 호프만-라 로슈 아게 | 테트라하이드로-피리도[3,4-b]인돌 에스트로겐 수용체 조절제 및 이의 용도 |
| EP4212536B1 (en) | 2015-07-02 | 2025-02-19 | F. Hoffmann-La Roche AG | Benzoxazepin oxazolidinone compounds and methods of use |
| LT3810283T (lt) * | 2018-06-21 | 2023-08-25 | F. Hoffmann-La Roche Ag | 3-((1r,3r)-1-(2,6-difluor-4-((1-(3-fluorpropil)azetidin-3- il)amino) fenil)-3-metil-1,3,4,9-tetrahidro-2h-pirido[3,4-b]indol-2-il)- 2,2- difluorpropan-1-olio tartrato druskos kietosios formos, jų paruošimo procesas ir jų naudojimo būdai vėžiui gydyti |
| CN115175679A (zh) * | 2020-03-06 | 2022-10-11 | 奥列马制药公司 | 治疗雌激素受体相关疾病的方法 |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017216280A1 (en) * | 2016-06-16 | 2017-12-21 | F. Hoffmann-La Roche Ag | TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF |
| WO2020023297A1 (en) * | 2018-07-23 | 2020-01-30 | Genentech, Inc. | Methods of treating cancer with pi3k inhibitor, gdc-0077 |
| WO2020037203A2 (en) * | 2018-08-17 | 2020-02-20 | Genentech, Inc. | Diagnostic and therapeutic methods for the treatment of breast cancer |
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| ES3030540T3 (en) | 2025-06-30 |
| EP4294395B1 (en) | 2025-03-26 |
| TW202237100A (zh) | 2022-10-01 |
| WO2022177844A1 (en) | 2022-08-25 |
| JP2024506385A (ja) | 2024-02-13 |
| CN117377472A (zh) | 2024-01-09 |
| US20230381155A1 (en) | 2023-11-30 |
| EP4294395A1 (en) | 2023-12-27 |
| EP4294395C0 (en) | 2025-03-26 |
| PL4294395T3 (pl) | 2025-06-23 |
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