TWI805995B - Antibacterial liquid for masks - Google Patents

Abstract

An antibacterial liquid used for masks comprises the following components in terms of weight percentage: a water repellant, an antibacterial agent and a solvent. The weight percentage (wt%) of the water repellant is 1%~10%; the weight percentage (wt%) of the antibacterial agent is 0.005%~1%; and the weight percentage (wt%) of the solvent is 89.001%~98.994% . In this way, the antibacterial liquid used for the mask acts on the mask, and the antibacterial liquid provides long-lasting antibacterial ability through the antibacterial agent, so that the antibacterial effect of the mask lasts for several days, and makes the mask hydrophobic through the water repellant , and form a hydrophobic surface on the surface of the mask to resist droplets more effectively, and can protect the antibacterial agent, avoid water mist from affecting the efficacy of the antibacterial agent, and use isopropanol or ethanol as a solvent to maintain the original electrostatic capacity of the mask. Furthermore, by adjusting the ratio of the water repellant, the antibacterial agent and the solvent, a relatively suitable ratio can be found to achieve a balance between performance and cost.

Description

Antibacterial liquid for masks

The invention relates to an antibacterial liquid, especially an antibacterial liquid for masks.

A mask is a disposable physical barrier that covers the nose and mouth to isolate pollutants in the environment. The main thing that masks need to protect against is the virus hidden in the mouth and nose droplets (which are hundreds of times larger than the virus), not the "clean" viruses that are not contaminated by the mouth and nose droplets. The diameter of the droplets caused by coughing and sneezing can range from 1 to 2000 microns, and the most common is 4 to 8 microns, so the droplets can be said to be pervasive. Influenza virus, SARS virus, and new coronavirus (COVID-19), etc., although the sizes of different viruses are different, the diameter of the virus is "nano" level, and the difference between the diameter of the virus and the droplet is 1000 times (1 micron = 1000 nm). Therefore, wearing a mask is considered an important anti-epidemic measure to control the virus, in order to prevent this type of virus transmitted by droplets.

The structure of general medical and surgical masks is a three-layer non-woven fabric structure. The outer layer is a hydrophobic PP spunbonded non-woven fabric, which can block droplets; the inner layer is a water-absorbent ES composite fiber non-woven fabric, which can improve the comfort of the mask wearer. Among them, the most important middle layer is melt-blown non-woven fabric (Melt-Blown Non-Woven, referred to as MB), which provides high-performance polypropylene melt-blown filter material as its core electrostatic filter layer, which can filter droplets containing bacteria or viruses for a long time The effect. However, general medical and surgical masks are limited to use, and the cumulative use does not exceed 8 hours. Even if the appearance is clean, it must be replaced after 6 to 8 hours of use.

Conventional technology such as Chinese utility model patent "mask with storage disinfectant function", its authorized announcement number is that CN211932689U discloses a kind of combination of disinfectant and mouth mask, and it comprises mouth mask body, it is characterized in that, described mouth mask body or hanging ear A small-capacity disinfectant bottle is arranged on the thread or the head-mounted belt body. However, the long-term effectiveness of the disinfectant is not considered. Furthermore, in terms of use, the disinfectant bottle can be removed while protecting the mouth and nose, and the disinfectant bottle can be squeezed to make the disinfectant spray out to disinfect frequently touched objects. It is very inconvenient, and the benefit is not high at the same time, just as the same effect can be achieved by placing the disinfectant bottle in the pocket of the carry-on clothes.

In view of this, how to get rid of the above deficiency is the technical difficulty that the inventor of this case wants to solve.

In view of the conventional use, the purpose of the present invention is to develop an antibacterial agent with long-acting antibacterial ability while maintaining the original electrostatic ability of the mask.

Another object of the present invention is to develop an antibacterial agent that has long-acting antibacterial ability, maintains the original electrostatic ability of the mask, and can cover the smell of solvents.

In order to achieve the purpose of the present invention, the present invention provides an antibacterial liquid for masks, which comprises the following components in terms of weight percentage: a water repellant, an antibacterial agent and a solvent. The weight percentage (wt%) of the water repellant is 1%~10%; the weight percentage (wt%) of the antibacterial agent is 0.005%~1%; and the weight percentage (wt%) of the solvent is 89.001%~98.994% .

Preferably, the water repellant is a fluorine water repellant or a fluorine-containing copolymer.

Preferably, the antibacterial agent is monoalkyl dimethyl benzyl ammonium chloride.

Preferably, the solvent is isopropanol or ethanol.

Preferably, the ratio of the water repellant to the antibacterial agent is 100:1~100: 10.

In order to achieve another object of the present invention, the present invention provides an antibacterial liquid for masks, which comprises the following components in terms of weight percentage: a water repellant, an antibacterial agent, an essential oil and a solvent. The weight percentage (wt%) of the water repellant is 1%~10%; the weight percentage (wt%) of the antibacterial agent is 0.005%~1%; the weight percentage (wt%) of the essential oil is 0.3%~3%; And the weight percentage (wt%) of the solvent is 86.001%-98.694%.

Preferably, the water repellent is a fluorine water repellent or a fluorine-containing copolymer.

Preferably, the antibacterial agent is monoalkyl dimethyl benzyl ammonium chloride.

Preferably, the essential oil is a tea tree essential oil or a lemon essential oil.

Preferably, the solvent is isopropanol or ethanol.

In this way, the antibacterial liquid used for the mask acts on the mask, and the antibacterial liquid provides long-term antibacterial ability through the antibacterial agent, so that the antibacterial effect of the mask lasts for several days, for example, three to five days. The antibacterial liquid passes through the water repellent to make the mask hydrophobic, and forms a hydrophobic surface on the surface of the mask to resist droplets more effectively, and can protect the antibacterial agent to prevent the outermost layer of the mask from wetting in the presence of water mist. affect the efficacy of the antimicrobial agent. The antibacterial liquid uses isopropanol or ethanol as a solvent to maintain the original electrostatic capacity of the mask, and by adjusting the ratio between the water repellant, the antibacterial agent and the solvent, a relatively suitable ratio can be found to achieve efficiency and cost balance between. In addition, the antibacterial liquid can mask the pungent smell of isopropyl alcohol through the essential oil.

[Fig. 1] is a schematic diagram of the formation of a bacteriostatic zone around the test paper.

[Fig. 2] is a schematic diagram of the area around the test paper covered with bacteria.

[Figure 3] is a schematic diagram of the inhibition zone of 1% antibacterial agent.

[Figure 4] is a schematic diagram of the inhibition zone of an antibacterial agent with a ratio of 0.005%.

[Fig. 5] is a test schematic diagram of the ratio relationship between water repellant and antibacterial agent.

〔Figure 6〕It is a test schematic diagram of the effect of isopropanol as the solvent on the original electrostatic capacity of the mask.

〔Figure 7〕It is a schematic diagram of testing the effect of ethanol as the solvent on the original electrostatic capacity of the mask.

〔Figure 8〕It is a schematic diagram of testing the original electrostatic capacity of the mask when the solvent is water.

[Figure 9] is a schematic diagram of the test for the essential oil of tea tree essential oil to mask the smell of isopropanol.

〔Figure 10〕is a schematic diagram of the test where the essential oil is lemon essential oil to mask the smell of isopropanol.

In order for your examiner to easily and concisely understand the other features and advantages of the present invention and the effects achieved, the present invention is described in detail as follows with accompanying drawings:

The invention provides an antibacterial liquid for masks, which comprises: a water repellant, an antibacterial agent and a solvent.

The water repellant can be a fluorine water repellant or a fluorine-containing copolymer, and its chemical formula is H _m CF _n (CF2) _p OH (wherein m+n=2, p=6~12). The function of the water repellent is to prevent the water on the surface of the mask from wetting the outermost layer of the mask, so that droplets (droplets are water mist produced by coughing, sneezing or talking) will immediately form water droplets as soon as they touch the surface of the mask, and take advantage of the situation slide. In detail, the water repellant can make the mask hydrophobic, and the surface of the mask forms a hydrophobic surface. Hydrophobic refers to the physical property of repelling water. When water comes into contact with a surface, the shape of the water changes according to the properties of the surface. Water may spread out on the surface, wet the surface, and the water is almost flat. Such a surface is called a hydrophilic surface, which means "water-loving". The angle formed is called the "contact angle". The contact angle of a hydrophilic surface is generally less than 80 degrees, which means that the contact angle is small, which means that water tends to spread on the surface. Another situation is that the water aggregates into water droplets and does not disperse on the surface, so the surface remains dry. Such a surface is called a hydrophobic surface (hydrophobic surface), which means "does not like water", and the angle formed by the water and the surface is relatively large , The contact angle of a hydrophobic surface is generally 80 degrees to 120 degrees, which means that the contact angle is relatively large, which means that water tends to gather together to form water droplets. In this way, the water repellant can make the surface of the mask form a hydrophobic surface, so that the mask can resist droplets more effectively. The water repellant can also protect the antibacterial agent, and avoid the outermost layer of the mask from being wetted by water mist and affecting the surface of the mask. Antimicrobial efficacy. Generally speaking, in order to form a hydrophobic surface, the contact angle must be at least greater than 90 degrees, preferably greater than 100 degrees, and greater than 100 degrees will make the surface have low wettability (in vernacular, it is not easy to wet), but as far as masks are concerned In other words, the contact angle is basically greater than 110 degrees in order to have the function of resisting droplets. That is to say, the higher the hydrophobicity of the mask, the less likely the droplets are to attach, disperse or dissolve on the surface of the mask.

The antibacterial agent can be Alkyl Dimethyl Benzyl Ammonium Chloride (Alkyl Dimethyl Benzyl Ammonium Chloride), which is a class of compounds related to benzalkonium chloride and also a quaternary ammonium Compounds, often used as cationic surfactants, are white or light yellow solids, which become viscous liquids after melting, with a slight pungent smell of chlorobenzene, can be dissolved in water, and can also be dissolved in organic solvents such as ethanol. It is obtained by the reaction of dimethyl ammonium and benzyl chloride, which is used for antibacterial and antivirus, but if the addition ratio is too high, the hydrophobicity of the mask will be reduced. Therefore, the antibacterial agent and the water repellent are used in the antibacterial liquid for masks The percentages need to be adjusted to match performance. The alkyl dimethyl ammonium chloride commonly includes: dodecyl dimethyl benzyl ammonium chloride, dodecyl trimethyl ammonium chloride, tetradecyl dimethyl benzyl ammonium chloride , cetyl dimethyl benzyl ammonium chloride, cetyl trimethyl ammonium chloride, octadecyl dimethyl benzyl ammonium chloride, benzalkonium chloride (Benzalkonium Chloride), etc.

The solvent can be sopropanol or ethanol, which is used for dissolving solutes such as the water repellant and the antibacterial agent, and then becomes a solution, which is convenient for stirring and mixing evenly. With the water repellent, the antibacterial agent and the solvent, the composition can be applied to the mask. In detail, the antibacterial liquid used for masks contains the water repellent in a weight percentage (wt%) of 1% to 10%; the antibacterial agent in a weight percentage (wt%) of 0.005% to 1% and the weight percentage (wt%) of the solvent is 89.001%~98.994%.

Through the above description, the composition of the antibacterial solution can be understood, and the following description and proof can be made to further improve the performance of the antibacterial solution by adjusting the ratio between the water repellant, the antibacterial agent and the solvent:

The instructions for antimicrobial testing are as follows:

The antibacterial test is to use the zone of inhibition method to observe the antibacterial ability. The zone of inhibition method is to spread the agent horizontally on the petri dish containing bacteria, so that the growth of bacteria around it is inhibited to form a transparent zone, that is, the zone of inhibition. Bacterial circle, to compare the assay method of antibacterial ability, its procedure is as follows:

Step 100: the process starts, first spread Escherichia coli on a petri dish.

Step 200: stain a test paper with the antibacterial agent, and place it in the center of the petri dish.

Step 300 : the process ends. Please refer to FIG. 1 . After culturing for one day, the bacteria cannot grow around the test paper, and a ring-shaped transparent circle is formed, which is the bacteriostatic zone.

In Fig. 1, the existence of the antibacterial zone indicates that the antibacterial agent acts on the test paper, and the test paper still has antibacterial effect after being placed for a long time. The size of the inhibition zone indicates the strength of the antibacterial ability of the antibacterial agent.

If as shown in Figure 2, the bacteria are all over the periphery of the test paper, which means that the antibacterial agent acts on the test paper and cannot prolong the duration of the antibacterial effect.

Furthermore, the mask will produce water mist during actual use. In order to simulate the actual use situation, the test paper is placed in front of a water mist machine in advance, and after a few days (for example, after four days), the test paper is then subjected to the above-mentioned antibacterial treatment. Test, if a bacteriostatic zone can be formed around the test paper, it means that the effectiveness of the antibacterial agent can last for several days (for example, four days) when the test paper has water mist.

As shown in Table 1 below: it can be seen that the ratio of the antibacterial agent affects the size of the inhibition zone, and the larger the ratio of the antibacterial agent, the stronger the antibacterial ability of the antibacterial agent, which proves that the antibacterial agent does have the effect of improving antibacterial ability . Please refer to Figure 3, which is a schematic diagram of the inhibition zone of an antibacterial agent with a ratio of 1%. It can be seen that the inhibition zone in the figure is very obvious; The schematic diagram of the circle shows that the inhibition zone in the figure is not obvious.

As shown in Table 2 below: It can be seen that the proportion of the water repellant affects the existence of the antibacterial zone, and then indicates that the proportion of the water repellent affects the prolongation of the antibacterial ability. The longer it exists, the more days the antibacterial ability will be extended, which proves that the water repellant does have the effect of protecting the antibacterial agent, so that the antibacterial ability of the antibacterial agent can be maintained for several days in the presence of water mist.

根據上述段落〔0034〕及〔0035〕諸項之說明，可得到結論：該抗菌劑的比例為0.005%~1%就能提供充足的抗菌能力，該抗菌劑的比例超過1%是浪費成本，該抗菌劑的比例未滿0.005%會導致抗菌能力不足，該抗菌劑的理想比例為0.03%~0.05%。於有水霧的情況下，該潑水劑的比例為1%~10%就能保護該抗菌劑，使該抗菌劑具有長效的抗菌能力，該抗菌劑作用於口罩上，口罩的抗菌效果可達數天之久。該潑水劑的比例超過10%是浪費成本，該抗菌劑的抗菌能力不需要延長到10天以上。如果要讓該抗菌劑的抗菌能力維持3~5天，該潑水劑的最佳比例為2.5%~5%。 Table II

According to the explanations of the above-mentioned paragraphs [0034] and [0035], it can be concluded that the ratio of the antibacterial agent is 0.005% to 1% to provide sufficient antibacterial ability, and the ratio of the antibacterial agent exceeding 1% is a waste of cost. The ratio of the antibacterial agent is less than 0.005%, which leads to insufficient antibacterial ability, and the ideal ratio of the antibacterial agent is 0.03% to 0.05%. In the case of water mist, the proportion of the water repellant is 1%~10%, which can protect the antibacterial agent and make the antibacterial agent have long-term antibacterial ability. The antibacterial agent acts on the mask, and the antibacterial effect of the mask can be improved. for several days. The ratio of the water repellent is more than 10% and it is a waste of cost, and the antibacterial ability of the antibacterial agent does not need to be extended to more than 10 days. If the antibacterial ability of the antibacterial agent is to be maintained for 3 to 5 days, the optimal ratio of the water repellant is 2.5% to 5%.

Please refer to FIG. 5 , which is a test schematic diagram of the ratio relationship between the water repellant and the antibacterial agent. The measurement of the contact angle can be measured by a contact angle goniometer or other methods. The measurement of the contact angle is the prior art and is not the focus of this case, so it will not be described in detail. It can be seen from Figure 5 that the ratio between the water repellant and the antibacterial agent is in the range of 100:0~100:15, and the water repellant can form a hydrophobic surface on the surface of the material (the aforementioned contact angle of the hydrophobic surface At least greater than 90 degrees), and the antibacterial agent has long-term antibacterial ability (the ratio of the antibacterial agent cannot be 0, otherwise the antibacterial agent cannot be protected), but in order to make the contact angle of the hydrophobic surface greater than 110 degrees to meet the requirements of the mask The ideal ratio between the water repellant and the antibacterial agent is in the range of 100:1~100:10.

The electrostatic test is described as follows:

The electrostatic test is to change the solvent of the antibacterial liquid, and then apply the antibacterial liquid to the mask, and use an electrostatic measuring device to measure the static electricity of the mask (once the material is charged, it is "statically charged", which is actually a measure charge), to compare whether each solvent will affect the original electrostatic capacity of the mask, the process is as follows:

Step 400: The process starts. The solvent of the antibacterial solution is isopropanol, and then the static electricity of the mask is measured with an electrostatic measuring device, and the charge displayed on the electrostatic measuring device is observed.

Step 500: The solvent of the antibacterial solution is changed to ethanol, and then the static electricity of the mask is measured with an electrostatic measuring device, and the charge displayed on the electrostatic measuring device is observed.

Step 600: the process ends, the solvent of the antibacterial solution is changed to water, and then the static electricity of the mask is measured with an electrostatic measuring device, and the charge displayed on the electrostatic measuring device is watched.

Please refer to Figure 6, which is a test schematic diagram of the effect of isopropanol on the original electrostatic capacity of the mask. It can be seen from Figure 6 that using isopropanol as the solvent can maintain the original electrostatic capacity of the mask without being affected. Please refer to Figure 7, which is a schematic diagram of the test that the solvent is ethanol, which affects the original electrostatic capacity of the mask. It can be seen from Figure 7 that using ethanol as the solvent can maintain the original electrostatic capacity of the mask without being affected. Please refer to Figure 8, which is a schematic diagram of the test of the solvent being water affecting the original electrostatic capacity of the mask. It can be seen from Figure 8 that it is not feasible to use water as the solvent, and the charge of the mask is directly zeroed, and the original electrostatic capacity of the mask is lost. In addition, if the proportion of the antibacterial agent exceeds 2%, it will also reduce the original electrostatic capacity of the mask.

If the solvent is selected as isopropanol, because the smell of isopropanol is relatively pungent, and the mask is attached to the nose, essential oils can be added to the antibacterial liquid to cover the smell of the solvent. At this time, the water repellant , the ratio of the antibacterial agent, the essential oil and the solvent should be adjusted, The antibacterial solution comprises the following components in terms of weight percentage: the water repellent has a weight percentage (wt%) of 1% to 10%; the antibacterial agent has a weight percentage (wt%) of 0.005% to 1%; the essential oil has The weight percentage (wt%) is 0.3%~3%; and the weight percentage (wt%) of the solvent is 86.001%~98.694%.

Please refer to Figure 9, which is a test schematic diagram of the essential oil being tea tree essential oil to cover the smell of isopropanol, and then please refer to Figure 10, which is a test schematic diagram of the essential oil being lemon essential oil to cover the smell of isopropanol, from Figure 9 and Figure 10 It can be seen that if the proportion of the essential oil is too small, the smell cannot be masked, and if the proportion of the essential oil is too large, it is wasteful and will reduce the contact angle (ie, reduce the hydrophobicity). The type of essential oil is not limited to tea tree essential oil or lemon essential oil, as long as it is essential oil, but the effect of masking the smell is relatively better than tea tree essential oil or lemon essential oil, which can effectively cover the smell of alcohols. The preferred ratio of this essential oil is 0.3%~3%, but the more ideal ratio is 0.5%~1%.

To sum up, the antibacterial liquid used for masks acts on the masks, and the antibacterial liquid provides long-term antibacterial ability through the antibacterial agent, so that the antibacterial effect of the masks lasts for several days, such as extending for three to five days. The antibacterial liquid passes through the water repellent to make the mask hydrophobic, and forms a hydrophobic surface on the surface of the mask to resist droplets more effectively, and can protect the antibacterial agent to prevent the outermost layer of the mask from wetting in the presence of water mist. affect the efficacy of the antimicrobial agent. The antibacterial liquid uses isopropanol or ethanol as a solvent to maintain the original electrostatic capacity of the mask, and by adjusting the ratio between the water repellant, the antibacterial agent and the solvent, a relatively suitable ratio can be found to achieve efficiency and cost balance between. In addition, the antibacterial liquid can mask the pungent smell of isopropyl alcohol through the essential oil.

The above discussion is only a preferred embodiment of the present invention, and is not used to limit the scope of the present invention; therefore, the equivalent modifications made within the scope of the spirit and scope of the present invention Decoration, combination, replacement or diversion, etc., should all be covered within the patent scope of the present invention.

Claims (5)

A kind of antibacterial liquid that is used for mouth mask comprises following components by weight percentage: a water repellant, its weight percentage (wt%) is 1%～10%, the chemical formula of this water repellant is H _m CF _n (CF2) _p OH (wherein m+n=2, p=6～12); An antibacterial agent, its weight percentage (wt%) is 0.005%～1%, and this antibacterial agent is an alkyl dimethyl benzyl ammonium chloride; And a solvent, which is isopropanol or ethanol, the weight percentage (wt%) is 89.001%~98.994%, and the ratio between the water repellant and the antibacterial agent is 100:1~100:10. Such as the antibacterial liquid used for masks according to claim 1, wherein the water repellent is a fluorine water repellent or a fluorine-containing copolymer. A kind of antibacterial liquid that is used for mouth mask comprises following components by weight percentage: a water repellant, its weight percentage (wt%) is 1%～10%, the chemical formula of this water repellant is H _m CF _n (CF2) _p OH (wherein m+n=2, p=6～12); An antibacterial agent, its weight percentage (wt%) is 0.005%～1%, and this antibacterial agent is an alkyl dimethyl benzyl ammonium chloride; An essential oil, whose weight percentage (wt%) is 0.3%~3%; and a solvent, which is an isopropanol or an ethanol, whose weight percentage (wt%) is 86.001%~98.694%. Such as the antibacterial liquid used for masks according to claim 3, wherein the water repellant is a fluorine water repellent or a fluorine-containing copolymer. As the antibacterial liquid for mask of claim 3, wherein the essential oil is a tea tree essential oil or a lemon essential oil.

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