TWI788648B - Chinese medicine composition for skin dressing as well as skin dressing and manufacturing method of the same - Google Patents

Abstract

A traditional Chinese medicine composition of a skin dressing, a skin dressing and a manufacturing method thereof, wherein the Chinese medicine composition of the skin dressing includes: Coptis chinensis, Scutellaria baicalensis, Cortex Phellodendron, Gardenia, Cortex Mori, Sophora flavescens, Forsythia, Gentiana, and gypsum And Smilax baicalensis. In this way, the side effects of skin diseases caused by the use of cancer targeted drugs can be effectively improved, so that patients can successfully receive regular cancer treatment and maintain a good quality of life during treatment.

Description

Traditional Chinese medicine composition of skin dressing, skin dressing and manufacturing method thereof

The invention relates to a traditional Chinese medicine composition of a skin dressing, a skin dressing and a manufacturing method thereof.

Cancer target drugs, such as epidermal growth factor receptor inhibitors (Epidermal Growth Factor Receptor Inhibitor, EGFRIs) can be divided into two major drugs: one is monoclonal antibody macromolecular drugs, such as Cetuximab (Erbitux, Erbidux), and the other One is a small-molecule drug EGFR inhibitor, such as Gefitinib (Iressa, Iressa), Erlotinib (Tarceva, Desoo), Lapatinib (Tykerb, Taijia Tablet), etc. The most common skin reaction of this type of target drug is papules Pustular acne (papulopustular acneiform eruption). And tyrosine kinase inhibitors (Tyrosine kinase inhibitors), such as: Sunitinib (Sutent, Shuai special), Sorafenib (Nexavar, Leisava), these are prone to "hand foot skin reaction" (Hand foot skin reaction, HFSR) , Erythema, keratinized thick calluses (corns), and even blisters will appear on the soles of the feet, toes, and outside of the feet under pressure. Other skin reactions include hair loss, dry skin, itchy skin, and seborrheic dermatitis-like rash. At present, the treatment methods of Western medicine are mostly supplemented by oral or external medication for acne, or combined with external steroid ointment for treatment. When inflammation is severe, even targeted drugs must be stopped.

In terms of traditional Chinese medicine, the point of view of traditional Chinese medicine is that the side effects of these skin diseases are drug eruptions caused by the internal invasion of drug poisons, and most of them are treated with traditional Chinese medicines that have the functions of clearing heat and detoxifying, clearing heat and cooling blood, clearing heat and purging fire. Existing ways to improve skin with traditional Chinese medicine, such as a Chinese herbal medicine anti-acne patch provided by the Republic of China Patent Publication No. I626054, include: a drug carrier, which has a first layer and a second layer, the first layer It has a porous structure, the second layer has a compact structure and stronger adhesion than the first layer, and the second layer is combined with one of the surfaces of the first layer, wherein the drug-loading system includes an anti-acne compound , which is selected from a Phellodendron Phellodendri extract with a concentration of 1 to 2 mg/ml, a Centella asiatica extract with a concentration of 1 to 3 mg/ml, a Polygonum cuspidatum extract with a concentration of 1 to 2 mg/ml, and a pomegranate peel extract with a concentration of The group consisting of 0.1 to 1mg/ml and a chamomile extract concentration of 0.1 to 1mg/ml, so that the anti-acne compound is a natural ingredient, and can effectively inhibit the growth of bacteria to achieve the effect of helping wound repair.

However, the ingredients used in the aforementioned patents are only Chinese herbal medicines, which may be relatively limited and time-consuming in improving the side effects of skin diseases.

Therefore, the inventor proposes a traditional Chinese medicine component of a skin dressing, which is suitable for improving the side effects of skin diseases caused by cancer target drugs. 750 parts by weight; Phellodendron 375 to 750 parts by weight; Gardenia 656.25 to 1031.25 parts by weight; Morus alba 187.5 to 562.5 parts by weight; Sophora flavescens root 375 to 750 parts by weight parts by weight; parts by weight of Forsythia 187.5 to 562.5; parts by weight of Gentiana 112.5 to 300; parts by weight of gypsum 862.5 to 1125; and parts by weight of Smilax 375 to 750.

The present invention is also a skin dressing, which is suitable for improving the side effects of skin diseases caused by cancer target drugs. In addition to the traditional Chinese medicine ingredients of the skin dressing, the skin dressing further includes: 20.276 30.414 parts by weight of pure water, 1.6 to 2.4 parts by weight of glycerin, 1.6 to 2.4 parts by weight of 1,3-butanediol (Butylene Glycol), 0.8 to 1.2 parts by weight Parts of sodium alginate, parts by weight of acetamidoethoxyethanol between 1.6 and 2.4 parts by weight, parts by weight of methyl p-hydroxybenzoate between 0.16 and 0.24 parts by weight, small parts by weight between 0.48 and 0.72 parts Sclerotin, 2.4 to 3.6 parts by weight of polyglycerol 6 stearate, 1.6 to 2.4 parts by weight of self-emulsifying glyceryl stearic acid, 0.8 to 1.2 parts by weight of hexadecane Potassium phosphate, 1.6 to 2.4 parts by weight of behenyl alcohol, 1.6 to 2.4 parts by weight of stearyl alcohol, 0.8 to 1.2 parts by weight of stearic acid, 4.8 to 7.2 parts by weight Parts by weight of isopropyl isostearate, parts by weight of isostearic acid between 2.4 and 3.6 parts by weight, parts by weight of octyldodecanol between 0.8 and 1.2 parts by weight, parts by weight between 1.6 and 2.4 caprylic/capric triglyceride, jojoba oil between 2.4 and 3.6 parts by weight, macadamia oil between 2.4 and 3.6 parts by weight, vitamin E between 0.4 and 0.6 parts by weight, 0.8 to 1.2 parts by weight of isododecane, 0.8 to 1.2 parts by weight of dimethylsiloxane, 0.2 to 0.3 parts by weight of phenoxyethanol, 0.004 to 0.006 parts by weight of Piroctone ethanolammonium salt and 0.08 to 0.12 parts by weight of allyl p-hydroxybenzoate.

The present invention is also a manufacturing method of traditional Chinese medicine components of skin dressings for improving side effects of skin diseases caused by cancer target drugs. Scutellaria baicalensis, 375 to 750 parts by weight of Cortex Phellodendri, 656.25 to 1031.25 parts by weight of Gardenia, 187.5 to 562.5 parts by weight of Cortex Morus alba, 375 to 750 parts by weight of Sophora flavescens root , 187.5 to 562.5 parts by weight of forsythia, 112.5 to 300 parts by weight of gentian, 862.5 to 1125 parts by weight of gypsum, 375 to 750 parts by weight of Smilax, and 18040 to 27060 parts by weight of water are mixed to form a mixed solution; and after boiling the mixed solution for 120 to 180 minutes, it is concentrated to a concentration between 20% and 40% to form a skin dressing.

The present invention is also a method for manufacturing skin dressings for improving the side effects of skin diseases caused by cancer target drugs, including the manufacturing method of the traditional Chinese medicine components of the above skin dressings, further comprising: seaweed in an amount of 0.8 to 1.2 parts by weight Sodium acid sodium and 0.48 to 0.72 parts by weight of sclerotin gum are dissolved with water as a solvent at 40 to 50 degrees Celsius; then add 20.276 to 30.414 parts by weight of pure water, 1.6 to 2.4 parts Parts by weight of glycerol, parts by weight of 1,3 to butanediol between 1.6 and 2.4 parts by weight, parts by weight of acetamidoethoxyethanol between 1.6 and 2.4 parts by weight, parts by weight between 0.16 and 0.24 parts by weight of The polyglycerol 6 stearate of methyl p-hydroxybenzoate and 2.4 to 3.6 parts by weight is heated to 70 to 80 degrees Celsius to form a first mixed solution; the parts by weight between 1.6 and 2.4 Emulsified glyceryl stearic acid, potassium cetyl phosphate between 0.8 and 1.2 parts by weight, behenyl alcohol between 1.6 and 2.4 parts by weight, stearyl alcohol between 1.6 and 2.4 parts by weight , 0.8 to 1.2 parts by weight of stearic acid, 4.8 to 7.2 parts by weight of isopropyl isostearate, 2.4 to 3.6 parts by weight of isostearic acid, 0.8 to 1.2 parts by weight Parts by weight of octyldodecanol, between 1.6 and 2.4 parts by weight of caprylic/capric triglycerides, between 2.4 and 3.6 parts by weight of jojoba oil, between 2.4 and 3.6 parts by weight Parts of macadamia soybean oil and 0.4 to 0.6 parts by weight of vitamin E are mixed and heated to 75 to 85 degrees Celsius to form a second mixed solution; the second mixed solution is added to the first mixed solution, and emulsified to form a second mixed solution Three mixed liquids; when the third mixed liquid is cooled to 55 to 65 degrees Celsius, add 0.8 to 1.2 parts by weight of isododecane, 0.8 to 1.2 parts by weight of dimethylsiloxane, 0.2 0.3 parts by weight of phenoxyethanol, 0.004 to 0.006 parts by weight of piroctone ethanolammonium salt and 0.08 to 0.12 parts by weight of propylene p-hydroxybenzoate; and the third When the temperature of the mixed solution is lowered to 25 to 30 degrees Celsius, 28 to 42 parts by weight of the concentrated mixed solution is added and mixed to form the skin dressing.

The present invention is also a skin dressing manufactured by the aforementioned manufacturing method of the skin dressing.

According to the above-mentioned technical features, the following effects can be achieved: Combining the above compounds with specific traditional Chinese medicine ingredients, and wet dressing and smearing with ointment, it is suitable for targeted drugs, such as Epidermal Growth Factor Receptor Inhibitors (EGFRIs) and Tyrosine Kinase Inhibitors (Tyrosine Kinase Inhibitors) Treatment of dermatological side effects induced by skin inhibitors (TKI) includes acne-like erythema (like acne form of skin rash) or papulopustular eruption (papulopustular eruption), skin itching (pruritus), skin dryness (xerosis), nail Paronychia, hand foot skin reaction (HFSR) and skin papules, pustules and other symptoms caused by chemotherapy drugs.

[The first figure] is a schematic flow chart of the embodiment of the present invention.

[Second Figure A] is the first photo of the skin application without using the embodiment of the present invention, and the shooting date: November 27, 2019.

[Picture 2 B] is photo 1 of using the skin dressing according to the embodiment of the present invention, and the shooting date: December 13, 2019.

[Third Picture A] is the second picture without using the skin dressing according to the embodiment of the present invention, taken on August 19, 2019.

[Third Picture B] is the second picture of using the skin dressing according to the embodiment of the present invention, and the shooting date: October 14, 2019.

[Picture 4 A] is photo 3 without using the skin dressing according to the embodiment of the present invention, date of shooting: June 10, 2019.

[Picture 4 B] is photo 3 using the skin dressing according to the embodiment of the present invention, date of shooting: August 5, 2019.

[Fifth Figure A] is the fourth photo without using the skin dressing according to the embodiment of the present invention, and the shooting date: August 7, 2019.

[Fifth Figure B] is the photo 4 of using the skin dressing according to the embodiment of the present invention, and the shooting date: December 18, 2019.

[Picture 6 A] is photo 5 without using the skin dressing of the embodiment of the present invention, and the shooting date: June 19, 2019.

[Picture 6 B] is photo 5 using the skin dressing according to the embodiment of the present invention, date of shooting: August 21, 2019.

Based on the above-mentioned technical features, the main functions of the traditional Chinese medicine ingredients, the skin dressing and its manufacturing method of the skin dressing of the present invention will be clearly presented in the following examples.

Please refer to the first figure, which discloses the manufacturing method of the skin dressing. The skin dressing is suitable for improving skin disease side effects caused by cancer target drugs.

Coptidis between 656.25 grams and 1031.25 grams, skullcap between 375 grams and 750 grams, cork between 375 grams and 750 grams, gardenia between 656.25 grams and 1031.25 grams , between 187.5 grams and 562.5 grams of Morus alba, between 375 grams and 750 grams of Sophora flavescens root, between 187.5 grams and 562.5 grams of forsythia, between 112.5 grams and 300 grams gentian, between 862.5 grams and 1125 grams of gypsum that has been crushed into fine powder, between 375 grams and 750 grams of Smilax, and between 18040 milliliters and 27060 milliliters of purified water Mixed into a mixture, the mixture was boiled for 150 minutes to 15000 ml, and concentrated to a concentration of 30% for later use.

Then, 0.8 to 1.2 parts by weight of sodium alginate (Sodium Alginate) and 0.48 to 0.72 parts by weight of sclerotium gum (Sclerotium Gum) were used as solvent in water at Dissolve at 40 to 50 degrees; add between 20.276 parts by weight and 30.414 parts by weight of pure water, between 1.6 parts by weight and 2.4 parts by weight of glycerin (Glycerin), between 1.6 parts by weight and 2.4 parts by weight Between 1,3-butanediol (Butylene Glycol), between 1.6 parts by weight to 2.4 parts by weight of acetamidoethoxyethanol (Acetamidoethoxyethanol), between 0.16 parts by weight to 0.24 parts by weight Methylparaben (Methylparaben) and polyglyceryl-6 stearate (Polyglyceryl-6 Stearate) between 2.4 parts by weight and 3.6 parts by weight are heated to 75 degrees Celsius to dissolve and become a first mixed solution spare.

Self-emulsifying glyceryl stearate (Glyceryl Stearate SE) between 1.6 parts by weight and 2.4 parts by weight, potassium cetyl phosphate (Potassium Cetyl Phosphate) between 0.8 parts by weight and 1.2 parts by weight, Between 1.6 parts by weight and 2.4 parts by weight of behenyl alcohol (Behenyl Alcohol), between 1.6 parts by weight and 2.4 parts by weight of stearyl alcohol (Stearyl Alcohol), between 0.8 parts by weight and 1.2 parts by weight Stearic Acid (Stearic Acid) between 4.8 to 7.2 parts by weight Isopropyl Isostearate (Isopropyl Isostearate) between 2.4 and 3.6 parts by weight Isostearic Acid, Octyldodecanol between 0.8 and 1.2 parts by weight, caprylic/capric triglyceride between 1.6 and 2.4 parts by weight (Caprylic/Capric Triglyceride), between 2.4 parts by weight and 3.6 parts by weight of jojoba oil (Jojoba Oil), between 2.4 parts by weight and 3.6 parts by weight of macadamia nut oil (Macadamia Nut Oil) and between 0.4 parts by weight to 0.6 parts by weight of vitamin E (Vitamin E) are mixed and heated to 80 degrees centigrade to dissolve and become a second mixed solution for later use.

The second mixed solution is added to the first mixed solution to form a third mixed solution after emulsification. The third mixed liquid is cooled, and when the third mixed liquid is cooled to 60 degrees Celsius, add between 0.8 to 1.2 parts by weight of isododecane (Isododecane), between 0.8 to 1.2 parts by weight Dimethicone (Dimethicone) between parts, Phenoxyethanol (Phenoxyethanol) between 0.2 parts by weight and 0.3 parts by weight, piroctone ethanol between 0.004 parts by weight and 0.006 parts by weight Ammonium salt (Piroctone Olamine) and 0.08 to 0.12 parts by weight of propylene paraben (Propylene Paraben) are mixed and stirred evenly. Continue to cool down the third mixed solution, when the third mixed solution is cooled to 28 degrees Celsius, add between 28 parts by weight and 42 parts by weight of the concentrated mixed solution, and mix evenly to form a skin dressing .

1. Inspection of heavy metal residues:

According to the regulations of the Ministry of Health and Welfare, the residual amount of heavy metal cadmium, lead, and arsenic in final cosmetic products shall not exceed 5ppm, lead shall not exceed 10ppm, and arsenic shall not exceed 3ppm. More than 5ppm, arsenic must not exceed 3ppm.

In order to confirm whether it complies with the aforementioned regulations, the inventor entrusted the food inspection team of the Inspection Analysis and Technology Extension Service Center of the National Chiayi University College of Life Sciences to inspect the heavy metal residues of the skin dressing, and the inspection result using an atomic absorption spectrometer was: cadmium 0.013ppm ; Lead 0.085ppm; Arsenic was not detected, which proves that the skin dressing really meets and is far below the Ministry of Health and Welfare's heavy metal limit for cosmetics and Chinese herbal medicines.

2. Inspection of pesticide residues:

The inventor also entrusts the National Chiayi University College of Life Sciences Inspection Analysis and Technology Promotion Service Center Food Inspection Group to carry out the inspection of pesticide residues on the skin dressing, and the inspection method uses Sanitation No. 1081900612 Announcement of Shishizi revised the inspection method of pesticide residues in food-multiple residue analysis method. The test results showed that none of the 380 pesticide residues were detected. on the skin.

3. Actual results

The actual experimental study of the skin dressing began on May 15, 2019, and the first patient was admitted on June 3, 2019. As of October 10, 2019, 25 patients were admitted, and 3 were excluded For patients with simple paronychia, the treatment and curative effect analysis of the side effects of skin diseases induced by targeted drugs were conducted in the remaining 22 patients. The skin dressing committee was produced by Kangfu Health Biotechnology Co., Ltd., approved by the IRB, and after a full explanation, the patient's consent was obtained and the patient's consent form approved by the IRB was signed.

It can be seen from the above table 1 that the most common skin disease side effect caused by targeted drugs in patients is acne-like rash (Rash acneiform). Plagued by rash, and the average toxicity grade was 2.30.

During the period of dermatological side effects caused by targeted drug treatment, apply the skin dressing directly on the body surface where there are dermatological side effects, 3 times a day with an interval of at least 4 hours. After use, the improvement results of dermatological side effects are as follows Table 2 shows.

After comparing the above table 1 and the above table 2, it can be found that after using the skin dressing, no patient has worsening side effects of skin diseases, and the proportion of patients with acne-like rash has dropped significantly from 90.91% to 31.82%. The toxicity grade It also dropped from 2.30 to 0.35, and the acneiform rash toxicity grades of all patients were controlled at 0 and 1. Other side effects of skin diseases, such as: dry skin (Dry Skin), itching (Pruritus), hand-foot disease (Palmar-plantar erythrodysesthesia) and skin ulcers (Skin ulcer), etc., have also improved, which proves that the skin application The drug does have a significant improvement effect on the side effects of skin diseases induced by targeted drugs.

In order to more intuitively illustrate the improvement effect brought by the skin dressing, the photos before and after the actual use of the skin dressing are shown below. In order to protect the privacy of the patients, the photos taken of the patients' faces are covered with color blocks to cover the eyes.

Please refer to the second picture A and the second picture B. The second picture A shows the side effects of skin diseases on the face caused by a patient with lung cancer after taking Tarceva's medicine. The second picture B shows the same patient on the face The effect of using this skin dressing on the face.

Please refer to the third picture A and the third picture B, the third picture A is the skin disease side effect on the patient's face when the skin dressing is not used, and the third picture B is the same patient using the skin dressing on the face The effect of skin application.

From the comparison between the second picture A and the second B picture, and the comparison between the third picture A and the third B picture, it can be found that the skin application drug has a good improvement effect on the side effects of skin diseases on the face, and can effectively reduce the facial side effects. acne.

Please refer to Figure 4A and Figure 4B. Figure 4A shows the side effects of skin disease on the patient's thigh without using the dressing, and Figure 4B shows the skin dressing on the thigh of the same patient The effect of the medicine.

Please refer to Figure 5 A and Figure 5 B. Figure 5 A shows the side effects of skin diseases on the patient's abdomen when the skin dressing was not used, and Figure 5 B shows the same patient using the skin dressing on the abdomen The effect of the medicine.

Please refer to Figure 6A and Figure 6B. Figure 6A shows the side effects of skin disease on the patient's buttocks without using the skin dressing, and Figure 6B shows the same patient using the skin dressing on the buttocks The effect of the medicine.

From the comparison between the fourth picture A and the fourth B picture, the comparison between the fifth picture A and the fifth picture B, and the comparison between the sixth picture A and the sixth picture B, it can be found that it is not only the side effects of skin diseases on the face , the skin dressing also has a good improvement effect on the side effects of skin diseases on thighs, abdomen and buttocks, etc., so the skin dressing can indeed effectively improve the side effects of skin diseases caused by targeted drugs.

Please refer back to the first picture. Toxic and side effects caused by drugs. From the point of view of traditional Chinese medicine, the drug poison invades internally, forming blood heat, damp heat and poison evil accumulate in the skin, and even heat poison turns into fire, burns the blood and overflows in the skin. surface. "Wind, heat, dampness, poison, and deficiency" are the main pathological mechanisms, and most of them use heat-clearing and detoxifying drugs as the main treatment principles, taking into account tonic drugs and surface-relieving drugs. Heat-clearing and detoxifying drugs have an inhibitory effect on excessive inflammatory reactions manifested as heat (such as the release of liquid inflammatory mediators and inflammatory cell proliferation), and have antibacterial, antiviral, antagonizing inflammatory cytokines, anti-free radical damage and protection Tissues, cells, etc. of the body.

In the embodiment of the present invention, the mixed liquid is selected from Coptis chinensis, Cortex Phellodendron, Huang Ling and Gardenia as the base, and then added Morus alba, Sophora flavescens root, Forsythia, Gentiana, gypsum and soil Fuqin and other Chinese herbal medicines are used to strengthen the effect of purging fire and detoxifying, clearing away heat and dampness. Examples of the efficacy of each component of the mixture are as follows: Huanglian Jiedu Decoction was first derived from Ge Hong’s "Elbow Reserve Emergency Prescriptions" Volume 2 "The Thirteenth Prescription for Treating Typhoid Fever", but the name of the prescription has not been published. To a prescription recorded in Wang Tao's "Waitai Secret Yao" in the Tang Dynasty and named it It is Huanglian Jiedu Decoction, which contains four flavors of Coptis chinensis, Scutellaria baicalensis, Cortex Phellodendron, and Gardenia. The disease is used the most. In dermatology, such as herpes simplex and herpes zoster of viral skin diseases, dermatitis includes contact dermatitis, eczema, atopic dermatitis, hormone-dependent dermatitis, etc., erythematous and scaly skin diseases such as psoriasis, skin Adnexal disease acne, seborrheic dermatitis, skin vasculitis such as allergic purpura and other skin diseases. The purging fire and detoxification effects of Huanglian Jiedu Decoction are mainly related to the anti-pathogenic microorganisms, anti-bacterial toxins, anti-pyretic and anti-inflammatory effects and the impact on immune function. Among them, it has a significant antibacterial effect on Staphylococcus aureus and a significant effect on bacterial toxins. Antibacterial effect, anti-inflammatory, anti-allergic and enhance the function of phagocytic cells. Huanglian Jiedu Decoction mainly contains three major types of ingredients: alkaloids, flavonoids, and iridoids. The active ingredients are berberine, baicalin, and baicalein. The main active ingredient is berberine, which has the broadest antibacterial spectrum, and has good antibacterial effect on both Gram-negative bacteria and Gram-positive bacteria. Another study pointed out that Berberine (Berberine) has antibacterial effects on hemolytic streptococcus, Staphylococcus aureus, Neisseria gonorrhoeae, Freund's, Shigella dysenteriae, etc., and has enhanced leukocyte phagocytosis. There are also varying degrees of inhibition. Coptidis and Phellodendron have antibacterial effects on Staphylococcus, Candida albicans, skin filamentous bacteria, Mycobacterium tuberculosis, etc. Coptidis, Scutellaria, Phellodendron, Sophora, Gardenia, etc. Scutellaria baicalensis and Scutellaria baicalensis can all inhibit the effect of Candida albicans. Scutellaria baicalensis, Coptis chinensis and Coptis chinensis decoction have anti-drug-resistant bacteria effects, and Scutellaria baicalensis has the widest spectrum of anti-drug-resistant bacteria. 12 kinds of drug-resistant bacteria such as bacilli have inhibitory effect.

Sophora flavescens contains matrine, oxymatrine, matrine, sophocarpine, oxysophocarpine and other alkaloids, which can resist Staphylococcus aureus, Salmonella, and Coxsackie virus (CVBⅢ) streptococcal cardiomyocyte lesion, inhibit HBV replication, has obvious anti-inflammatory, anti-allergic, anti-viral, anti-parasitic, anti-arrhythmia, immune regulation and other pharmacological effects. Forsythia contains forsythiaside, forsythin, pinoresinol and phylligenin, etc., which can inhibit the production of chemotactic hormones in human keratinocytes activated by TNF-α/IFN-γ, and have inhibitory effects on Escherichia coli, Neisseria gonorrhoeae, meningitis, and Salmonella. Morus alba extract with methanol has anti-inflammatory effect, and the components of sanggenon B, albanol B and sanggenon D can inhibit the production of NO in LPS-stimulated RAW264.7 cells, and albanol B can reduce the production of cytokines in the pro-inflammatory response and reduce the expression of nitric oxide synthase (iNOS) and cyclooxvgenase-2 (COX-2), and Morus alba contains flavonoids, alkaloids and stilbenes, which have antibacterial, whitening, cytotoxic, anti-inflammatory and anti-hyperlipidemic effects characteristic. Gentiana is known to relieve skin lesions such as rough surface, flaking and crusting, as well as prevent reduction of erythema and melanin index in mouse skin tests. Smilax smilax protects dermal fibroblasts against UV-induced skin aging and also has protective effects against oxidative stress. The main component of gypsum is CaSO ₄ , which can maintain the normal water content of the skin, increase the concentration of intracellular calcium ions, the activity of protein kinase C (PKC), extracellular signal-regulated kinase (ERK) and cAMP response element binding protein (CREB ) concentration of phosphorylation.

According to the above description, it can also be known that the skin dressing made of the mixed solution does have the effect of improving the side effects of skin diseases.

Based on the description of the above-mentioned embodiments, it is possible to fully understand the operation of the present invention, use and the effect that the present invention produces, but the above-mentioned embodiments are only preferred embodiments of the present invention, and should not be used to limit the implementation of the present invention. The scope, that is, the simple equivalent changes and modifications made according to the patent scope of the present invention and the content of the description of the invention, all fall within the scope of the present invention.

Claims (4)

A traditional Chinese medicine ingredient of a skin dressing, which is suitable for improving the side effects of papulopustular acne skin diseases caused by a cancer target drug epidermal growth factor receptor blocker. Parts by weight; parts by weight of Scutellaria baicalensis 375 to 750; parts by weight of Phellodendron 375 to 750; parts by weight of Gardenia 656.25 to 1031.25; parts by weight of Cortex Morus alba 187.5 to 562.5; to 750 parts by weight; forsythia 187.5 to 562.5 parts by weight; gentian 112.5 to 300 parts by weight; gypsum 862.5 to 1125 parts by weight; parts by weight. A skin dressing, which is suitable for improving the side effects of papulopustoid acne skin diseases caused by the cancer target drug epidermal growth factor receptor blocker. The skin dressing contains the traditional Chinese medicine ingredients of the skin dressing of claim 1, further comprising: 20.276 to 30.414 parts by weight of pure water, 1.6 to 2.4 parts by weight of glycerin, 1,3-butanediol between 1.6 and 2.4 parts by weight, and seaweeds between 0.8 and 1.2 parts by weight Acetylaminoethoxyethanol in parts by weight between sodium bicarbonate, 1.6 to 2.4 parts, methyl p-hydroxybenzoate in parts by weight between 0.16 and 0.24, sclerotinin in parts by weight between 0.48 and 0.72 , 2.4 to 3.6 parts by weight of polyglycerol 6 stearate, 1.6 to 2.4 parts by weight of self-emulsifying glyceryl stearic acid, 0.8 to 1.2 parts by weight of potassium cetyl phosphate , Twenty-two parts by weight between 1.6 and 2.4 Alkanol, 1.6 to 2.4 parts by weight of stearyl alcohol, 0.8 to 1.2 parts by weight of stearic acid, 4.8 to 7.2 parts by weight of isopropyl isostearate, 2.4 to 3.6 parts by weight The isostearic acid of between 0.8 and 1.2 parts by weight, the caprylic acid/capric triglyceride between 1.6 and 2.4 parts by weight, the Parts by weight of jojoba oil, 2.4 to 3.6 parts by weight of macadamia oil, 0.4 to 0.6 parts by weight of vitamin E, 0.8 to 1.2 parts by weight of isododecane, 0.8 to 1.2 parts by weight Parts by weight of dimethylsiloxane, parts by weight of phenoxyethanol between 0.2 and 0.3 parts by weight, parts by weight of piroctone ethanolammonium salt between 0.004 and 0.006 parts by weight, and parts by weight between 0.08 and 0.12 parts by weight Allyl p-hydroxybenzoate. A method for manufacturing a traditional Chinese medicine component of a skin dressing for improving side effects of papulopustular acne skin disease caused by a cancer target drug epidermal growth factor receptor blocker, comprising: 656.25 to 1031.25 parts by weight of Coptidis Rhizome , 375 to 750 parts by weight of Scutellaria baicalensis, 375 to 750 parts by weight of Cortex Phellodendri, 656.25 to 1031.25 parts by weight of Gardenia, 187.5 to 562.5 parts by weight of Cortex Mori, 375 to 562.5 parts by weight 750 parts by weight of Sophora flavescens root, 187.5 to 562.5 parts by weight of forsythia, 112.5 to 300 parts by weight of gentian, 862.5 to 1125 parts by weight of gypsum, 375 to 750 parts by weight Between the parts by weight of Smilax baicalensis and the water between 18040 and 27060 parts by weight to form a mixed liquid; Become a skin dressing. A method for manufacturing a skin dressing for improving the side effects of papulopustular acne skin disease caused by a cancer target drug epidermal growth factor receptor blocker, including a method for manufacturing the traditional Chinese medicine components of the skin dressing of claim 3, further It comprises: dissolving sodium alginate between 0.8 to 1.2 parts by weight and sclerotinia gelatin between 0.48 and 0.72 parts by weight with water as a solvent at 40 degrees Celsius to 50 degrees Celsius; 20.276 to 30.414 parts by weight of pure water, 1.6 to 2.4 parts by weight of glycerin, 1.6 to 2.4 parts by weight of 1,3 to butanediol, 1.6 to 2.4 parts by weight of Acetylaminoethoxyethanol, 0.16 to 0.24 parts by weight of methyl p-hydroxybenzoate and 2.4 to 3.6 parts by weight of polyglycerol 6 stearate, heated to 70 to 80 degrees Celsius Become a first mixed liquid; With the self-emulsifying glycerol stearic acid between 1.6 to 2.4 parts by weight, the potassium hexadecyl phosphate between 0.8 to 1.2 parts by weight, the Docosanol, the stearyl alcohol of 1.6 to 2.4 parts by weight, the stearic acid of 0.8 to 1.2 parts by weight, the isopropyl isostearate of 4.8 to 7.2 parts by weight, 2.4 Between 3.6 parts by weight of isostearic acid, between 0.8 and 1.2 parts by weight of octyldodecanol, between 1.6 and 2.4 parts by weight of caprylic/capric triglycerides, between 2.4 and 3.6 The jojoba oil between 2.4 and 3.6 parts by weight and the vitamin E between 0.4 and 0.6 parts by weight are mixed and heated to 75 to 85 degrees Celsius to form a second mixed solution; Add the second mixed solution to the first mixed solution, and emulsify to form a third mixed solution; when the temperature of the third mixed solution is lowered to 55 to 65 degrees Celsius, add 0.8 to 1.2 parts by weight of isododecane , dimethylsiloxane between 0.8 and 1.2 parts by weight, phenoxyethanol between 0.2 and 0.3 parts by weight, piroctone ethanolammonium salt between 0.004 and 0.006 parts by weight and 0.08 to 0.12 Between 28 and 42 parts by weight of the propylene p-hydroxybenzoate mixed; and when the third mixed solution is cooled to 25 to 30 degrees Celsius, add 28 to 42 parts by weight of the concentrated mixed solution, and mix to form the skin Dressing.

Images