TWI763632B - 用於重症治療時之鎮靜方法及非口服調配物 - Google Patents
用於重症治療時之鎮靜方法及非口服調配物Info
- Publication number
- TWI763632B TWI763632B TW105125498A TW105125498A TWI763632B TW I763632 B TWI763632 B TW I763632B TW 105125498 A TW105125498 A TW 105125498A TW 105125498 A TW105125498 A TW 105125498A TW I763632 B TWI763632 B TW I763632B
- Authority
- TW
- Taiwan
- Prior art keywords
- gaboxadol
- administered
- pharmaceutically acceptable
- sedation
- acceptable salt
- Prior art date
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Anesthesiology (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562203748P | 2015-08-11 | 2015-08-11 | |
| US201562203731P | 2015-08-11 | 2015-08-11 | |
| US62/203,748 | 2015-08-11 | ||
| US62/203,731 | 2015-08-11 | ||
| US14/834,027 US9399034B1 (en) | 2015-08-11 | 2015-08-24 | Methods of sedation during critical care treatment |
| US14/834,027 | 2015-08-24 | ||
| US15/185,650 US9717716B2 (en) | 2015-08-11 | 2016-06-17 | Methods of sedation during critical care treatment |
| US15/185,650 | 2016-06-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201717944A TW201717944A (zh) | 2017-06-01 |
| TWI763632B true TWI763632B (zh) | 2022-05-11 |
Family
ID=59687449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW105125498A TWI763632B (zh) | 2015-08-11 | 2016-08-10 | 用於重症治療時之鎮靜方法及非口服調配物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20180235942A1 (https=) |
| EP (1) | EP3334427A4 (https=) |
| JP (1) | JP6857647B2 (https=) |
| KR (1) | KR20180048707A (https=) |
| CN (1) | CN108135889A (https=) |
| AU (1) | AU2016304737B2 (https=) |
| CA (1) | CA2994952A1 (https=) |
| CO (1) | CO2018002534A2 (https=) |
| IL (1) | IL257296B2 (https=) |
| MX (1) | MX394213B (https=) |
| PE (1) | PE20181332A1 (https=) |
| TW (1) | TWI763632B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4541420A3 (en) | 2015-07-17 | 2025-06-25 | Ovid Therapeutics Inc. | Methods of treating developmental disorders with gaboxadol |
| EP3481387A4 (en) | 2016-08-11 | 2020-04-08 | Ovid Therapeutics Inc | METHOD AND COMPOSITIONS FOR TREATING EPILEPTIC DISEASES |
| US10071083B2 (en) | 2017-02-03 | 2018-09-11 | Ovid Therapeutics Inc | Use of gaboxadol in the treatment of tinnitus |
| WO2020061410A1 (en) | 2018-09-20 | 2020-03-26 | Ovid Therapeutics Inc. | Use of gaboxadol for the treatment of tourette syndrome, tics and stuttering |
| JP2022514194A (ja) | 2018-11-21 | 2022-02-10 | セルテゴ セラピューティクス インコーポレイテッド | 自殺のリスクを低減し、うつ病を迅速に軽減するためのガボキサドール |
| WO2020131856A1 (en) | 2018-12-17 | 2020-06-25 | Ovid Therapeutics Inc. | Use of gaboxadol for the treatment of non-24 hour sleep-wake disorder |
| MX2022014599A (es) | 2020-05-20 | 2022-12-16 | Certego Therapeutics Inc | Gaboxadol deuterado en anillo y su uso para el tratamiento de trastornos psiquiatricos. |
| US20220218740A1 (en) * | 2020-10-25 | 2022-07-14 | Vaporworks Nursing Anesthesia Inc. | Opioid-free compositions for anesthesiological applications and related methods and systems |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6071933A (en) * | 1999-12-03 | 2000-06-06 | Diversified Medical Innovations, Inc. | Homogeneous remifentanil-propofol blend for patient controlled anesthesia and process for its use |
| US20050215521A1 (en) * | 2003-12-22 | 2005-09-29 | Karim Lalji | Modafinil combination therapy for improving sleep quality |
| DK1742624T3 (da) * | 2004-02-18 | 2010-03-08 | Sepracor Inc | Dopamin-agonist-kombinationsterapi med sedativer til forbedring af søvnkvalitet |
| US20090143335A1 (en) * | 2007-10-29 | 2009-06-04 | H. Lundbeck A/S | Modified absorption formulation of gaboxadol |
| US9399034B1 (en) * | 2015-08-11 | 2016-07-26 | Ovid Therapeutics Inc | Methods of sedation during critical care treatment |
-
2016
- 2016-08-02 JP JP2018506932A patent/JP6857647B2/ja not_active Expired - Fee Related
- 2016-08-02 CA CA2994952A patent/CA2994952A1/en active Pending
- 2016-08-02 CN CN201680059253.3A patent/CN108135889A/zh active Pending
- 2016-08-02 PE PE2018000199A patent/PE20181332A1/es not_active Application Discontinuation
- 2016-08-02 MX MX2018001720A patent/MX394213B/es unknown
- 2016-08-02 AU AU2016304737A patent/AU2016304737B2/en not_active Ceased
- 2016-08-02 US US15/751,680 patent/US20180235942A1/en not_active Abandoned
- 2016-08-02 EP EP16835628.5A patent/EP3334427A4/en not_active Withdrawn
- 2016-08-02 KR KR1020187007146A patent/KR20180048707A/ko not_active Withdrawn
- 2016-08-10 TW TW105125498A patent/TWI763632B/zh not_active IP Right Cessation
-
2018
- 2018-02-01 IL IL257296A patent/IL257296B2/en unknown
- 2018-03-09 CO CONC2018/0002534A patent/CO2018002534A2/es unknown
Non-Patent Citations (1)
| Title |
|---|
| 期刊 Borthwick, Mark. "Pharmacology and pharmacokinetics of sedative agents." Journal of the Intensive Care Society. 9(3): 253-254, Oct 2008. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2994952A1 (en) | 2017-02-16 |
| JP2018522920A (ja) | 2018-08-16 |
| EP3334427A1 (en) | 2018-06-20 |
| AU2016304737B2 (en) | 2021-03-11 |
| JP6857647B2 (ja) | 2021-04-14 |
| US20180235942A1 (en) | 2018-08-23 |
| IL257296B2 (en) | 2023-02-01 |
| IL257296A (en) | 2018-03-29 |
| MX2018001720A (es) | 2018-09-06 |
| AU2016304737A1 (en) | 2018-02-22 |
| MX394213B (es) | 2025-03-24 |
| IL257296B (en) | 2022-10-01 |
| CO2018002534A2 (es) | 2018-05-31 |
| EP3334427A4 (en) | 2019-02-06 |
| TW201717944A (zh) | 2017-06-01 |
| KR20180048707A (ko) | 2018-05-10 |
| CN108135889A (zh) | 2018-06-08 |
| PE20181332A1 (es) | 2018-08-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |