TWI755629B - 含鎮靜藥物之緩釋藥物組合物及其用途 - Google Patents
含鎮靜藥物之緩釋藥物組合物及其用途 Download PDFInfo
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- TWI755629B TWI755629B TW108132920A TW108132920A TWI755629B TW I755629 B TWI755629 B TW I755629B TW 108132920 A TW108132920 A TW 108132920A TW 108132920 A TW108132920 A TW 108132920A TW I755629 B TWI755629 B TW I755629B
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- pharmaceutical composition
- lipid
- dexmedetomidine
- liposome
- sedative drug
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 59
- 239000000932 sedative agent Substances 0.000 title claims abstract description 26
- 238000013268 sustained release Methods 0.000 title description 12
- 239000012730 sustained-release form Substances 0.000 title description 12
- 239000002502 liposome Substances 0.000 claims abstract description 71
- 150000002632 lipids Chemical class 0.000 claims abstract description 54
- 239000003814 drug Substances 0.000 claims abstract description 31
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 18
- 230000036407 pain Effects 0.000 claims abstract description 17
- 239000000203 mixture Substances 0.000 claims description 59
- 229960004253 dexmedetomidine Drugs 0.000 claims description 57
- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 claims description 35
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- 238000007918 intramuscular administration Methods 0.000 claims description 13
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 10
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- ZMANZCXQSJIPKH-UHFFFAOYSA-O triethylammonium ion Chemical compound CC[NH+](CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-O 0.000 claims description 9
- PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 claims description 8
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- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 claims description 7
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- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims description 5
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- BIABMEZBCHDPBV-UHFFFAOYSA-N dipalmitoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCCCC BIABMEZBCHDPBV-UHFFFAOYSA-N 0.000 claims description 4
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- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims description 2
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- HRLIOXLXPOHXTA-NSHDSACASA-N dexmedetomidine Chemical compound C1([C@@H](C)C=2C(=C(C)C=CC=2)C)=CN=C[N]1 HRLIOXLXPOHXTA-NSHDSACASA-N 0.000 claims 3
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 7
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- VPNGEIHDPSLNMU-MERQFXBCSA-N dexmedetomidine hydrochloride Chemical compound Cl.C1([C@@H](C)C=2C(=C(C)C=CC=2)C)=CNC=N1 VPNGEIHDPSLNMU-MERQFXBCSA-N 0.000 description 7
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A61K9/1278—Post-loading, e.g. by ion or pH gradient
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Pain & Pain Management (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Anesthesiology (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862730713P | 2018-09-13 | 2018-09-13 | |
| US62/730,713 | 2018-09-13 |
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| TW202023618A TW202023618A (zh) | 2020-07-01 |
| TWI755629B true TWI755629B (zh) | 2022-02-21 |
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| TW108132920A TWI755629B (zh) | 2018-09-13 | 2019-09-12 | 含鎮靜藥物之緩釋藥物組合物及其用途 |
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| US (1) | US20220054455A1 (enExample) |
| EP (1) | EP3849532A4 (enExample) |
| JP (1) | JP7482487B2 (enExample) |
| CN (1) | CN112654348A (enExample) |
| TW (1) | TWI755629B (enExample) |
| WO (1) | WO2020056102A1 (enExample) |
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| US12472158B2 (en) * | 2019-02-27 | 2025-11-18 | Vanderbilt University | Methods of treating trigeminal nerve pain |
| WO2021211575A1 (en) * | 2020-04-13 | 2021-10-21 | The Regents Of The Univefisity Of California | Compositions comprising propofol, ketamine, and non-opioid analgesic, and methods of use |
| CN116688137B (zh) * | 2023-07-21 | 2024-05-14 | 中国医学科学院北京协和医院 | 一种基于核壳结构的药物组合物及应用 |
| CN118986892A (zh) * | 2024-09-29 | 2024-11-22 | 济南大学 | 一种醋酸阿比特龙胆盐脂质体组合物及其制备方法 |
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| MX9700850A (es) * | 1995-06-09 | 1997-09-30 | Euro Celtique Sa | Formulaciones y metodos para proporcionar anestesia local prolongada. |
| IL140892A0 (en) * | 1998-08-12 | 2002-02-10 | Yissum Res Dev Co | Liposomal bupivacaine compositions prepared using an ammonium sulfate gradient |
| AU2003298738A1 (en) * | 2002-11-26 | 2004-06-18 | Su-Ming Chiang | Liposomal formulations |
| WO2006027787A1 (en) * | 2004-09-09 | 2006-03-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Liposomal compositions of glucocorticoid and glucocorticoid derivatives |
| CN101756902B (zh) * | 2008-12-23 | 2011-10-05 | 上海医药工业研究院 | 一种可乐定多囊脂质体及其制备方法 |
| BR112013016365A2 (pt) * | 2010-12-27 | 2018-06-26 | Terumo Corp | composição de lipossoma e processo para produção do mesmo |
| US20130096170A1 (en) * | 2011-10-14 | 2013-04-18 | Hospira, Inc. | Methods of treating pediatric patients using dexmedetomidine |
| AU2013256008B2 (en) * | 2012-05-04 | 2016-02-25 | The Johns Hopkins University | Lipid-based drug carriers for rapid penetration through mucus linings |
| WO2014121211A2 (en) * | 2013-02-01 | 2014-08-07 | Zoneone Pharma, Inc. | Remote loading of sparingly water-soluble drugs into liposomes |
| EP2968145A1 (en) * | 2013-03-13 | 2016-01-20 | Mallinckrodt LLC | Modified docetaxel liposome formulations |
| ES2777223T3 (es) * | 2013-03-15 | 2020-08-04 | Taiwan Liposome Co Ltd | Composición de liposoma para liberación controlada de fármaco |
| US9895313B2 (en) * | 2015-03-03 | 2018-02-20 | Cureport, Inc. | Combination liposomal pharmaceutical formulations |
| WO2016191547A1 (en) * | 2015-05-26 | 2016-12-01 | Comfort Care For Animals Llc | Liposome loading |
| US11344498B2 (en) * | 2015-10-08 | 2022-05-31 | The Children's Medical Center Corporation | Compositions and methods for on-demand high-efficiency triggerable anesthesia |
| MX2018008507A (es) * | 2016-01-11 | 2019-07-04 | Merrimack Pharmaceuticals Inc | Inhibición de proteína relacionada con ataxia telangiectasia y rad3 (atr). |
| EP3829539A4 (en) * | 2018-08-02 | 2022-05-04 | Taiwan Liposome Company, Ltd. | DELAYED RELEASE COMPOSITIONS WITH A THERAPEUTIC AGENT FOR THE TREATMENT OF DEPRESSION OR ANXIETY AND USES THEREOF |
| US12285524B2 (en) * | 2018-08-08 | 2025-04-29 | Taiwan Liposome Co., Ltd. | Sustained-release pharmaceutical compositions comprising an antipsychotic drug and uses thereof |
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2019
- 2019-09-12 TW TW108132920A patent/TWI755629B/zh active
- 2019-09-12 EP EP19860619.6A patent/EP3849532A4/en active Pending
- 2019-09-12 US US17/274,850 patent/US20220054455A1/en active Pending
- 2019-09-12 WO PCT/US2019/050767 patent/WO2020056102A1/en not_active Ceased
- 2019-09-12 JP JP2021513789A patent/JP7482487B2/ja active Active
- 2019-09-12 CN CN201980057845.5A patent/CN112654348A/zh active Pending
Also Published As
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| TW202023618A (zh) | 2020-07-01 |
| WO2020056102A1 (en) | 2020-03-19 |
| EP3849532A1 (en) | 2021-07-21 |
| JP2022500398A (ja) | 2022-01-04 |
| JP7482487B2 (ja) | 2024-05-14 |
| CN112654348A (zh) | 2021-04-13 |
| EP3849532A4 (en) | 2022-06-08 |
| US20220054455A1 (en) | 2022-02-24 |
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