TWI745764B - 一種鴉片類物質受體激動劑的結晶形式及製備方法 - Google Patents

一種鴉片類物質受體激動劑的結晶形式及製備方法 Download PDF

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Publication number
TWI745764B
TWI745764B TW108136910A TW108136910A TWI745764B TW I745764 B TWI745764 B TW I745764B TW 108136910 A TW108136910 A TW 108136910A TW 108136910 A TW108136910 A TW 108136910A TW I745764 B TWI745764 B TW I745764B
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Taiwan
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solvent
crystal form
angle
formula
crystalline form
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TW108136910A
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English (en)
Chinese (zh)
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TW202014188A (zh
Inventor
邵啟雲
杜振興
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大陸商江蘇恒瑞醫藥股份有限公司
大陸商上海恒瑞醫藥有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW108136910A 2018-10-12 2019-10-14 一種鴉片類物質受體激動劑的結晶形式及製備方法 TWI745764B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201811186669 2018-10-12
CN201811186669.9 2018-10-12

Publications (2)

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TW202014188A TW202014188A (zh) 2020-04-16
TWI745764B true TWI745764B (zh) 2021-11-11

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TW108136910A TWI745764B (zh) 2018-10-12 2019-10-14 一種鴉片類物質受體激動劑的結晶形式及製備方法

Country Status (3)

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CN (1) CN112638906B (fr)
TW (1) TWI745764B (fr)
WO (1) WO2020073984A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113624898B (zh) * 2021-08-23 2023-08-25 成都诺和晟泰生物科技有限公司 一种手性镇痛类多肽药物的纯化方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201718558A (zh) * 2015-10-15 2017-06-01 江蘇恆瑞醫藥股份有限公司 氧雜螺環類衍生物、其製備方法及其在醫藥上的應用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5912169B2 (ja) * 2011-03-23 2016-04-27 トレベナ・インコーポレイテッドＴｒｅｖｅｎａ， Ｉｎｃ． オピオイド受容体リガンド並びにそれらの使用方法及び製造方法
US11014914B2 (en) * 2017-04-14 2021-05-25 Jiangsu Hengrui Medicine Co., Ltd. Opioid receptor (MOR) agonist salt, fumarate salt crystal form I thereof and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201718558A (zh) * 2015-10-15 2017-06-01 江蘇恆瑞醫藥股份有限公司 氧雜螺環類衍生物、其製備方法及其在醫藥上的應用

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CN112638906B (zh) 2022-05-27
CN112638906A (zh) 2021-04-09
WO2020073984A1 (fr) 2020-04-16
TW202014188A (zh) 2020-04-16

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