TWI726958B - Herbicidal composition and method for controlling plant growth - Google Patents

Abstract

A synergistic herbicidal composition is provided, the composition comprising a herbicidally effective amount of (A) metribuzin and (B) flupyrsulfuron. A method of controlling plant growth at a locus comprises applying to the locus herbicidally effective amounts of both metribuzin and flupyrsulfuron.

Description

Herbicide composition and method for controlling plant growth

The invention relates to a herbicidal composition. The present invention also relates to a method of controlling undesired plant growth, and particularly undesired plant growth in crops, which method includes the use of the aforementioned composition.

Undesirable plants inhibit the growth of crops and protect crops from undesirable plant inhibition, a long-term problem facing agriculture. In order to solve this problem, researchers have tried to develop a wide range of chemicals and chemical formulations that can effectively control the growth of such undesirable plants. The literature has revealed many types of chemical herbicides, and a large number of chemical herbicides are in commercial use.

It has been proven that some herbicidal active ingredients are more effective when applied in combination than when applied alone. This effect is called "synergy". According to the Herbicide Handbook of the Weed Science Society of America, Seventh Edition, 1994, p. 318, "synergism" is the interaction of two or more factors that make The combined effect is greater than the effect predicted based on the response to each factor administered alone.

It is known that metribuzin and flupyrsulfuron are two compounds with herbicidal activity and are used to control undesired plant growth. Both metronidazole and fluflusulfuron were disclosed in The Pesticides Manual published by The British Crop Protection Council., Twelfth Edition, 2000. Both compounds are also commercially available in a range of compositions.

-5-酮)；4-胺基-6-三級丁基-3-甲硫基-1,2,4-三

-5(4H)-酮具有下列化學結構：

Miebijing (IUPAC name: 4-amino-6-tertiary butyl-4,5-dihydro-3-methylthio-1,2,4-tri

-5-one); 4-amino-6-tertiary butyl-3-methylthio-1,2,4-tri

-5(4H)-ketone has the following chemical structure:

Metronidazole is an inhibitor of plant photosynthesis. The compound can be absorbed by the roots and leaves of the plant, and then transferred to the xylem. Metronidazole can effectively control grasses and broad-leaved weeds. Metronidazole is commercially available in the herbicidal composition, and its preparation method is known in the art.

Flufensulfuron sodium (IUPAC name: Methyl 2-(4,6-Dimethoxypyrimidin-2-ylaminocarboxamidosulfonyl)-6-trifluoromethylnicotinic acid monosodium Salt) has the following chemical structure:

Fluflusulfuron sodium is commercially available, and its preparation method is known in the art. Flufensulfuron sodium is a branched chain amino acid synthesis (ALS) inhibitor. The compound acts by inhibiting the biosynthesis of the essential amino acids valine and isoleucine, thereby stopping plant cell division and plant growth.

The most surprising thing is that it has now been found that metronidazole and fluflusulfuron-methyl show a synergistic effect in the control of plant growth when applied in combination, for example, in a composition containing the two compounds or when applied separately to the to-be-treated Location.

Compared with using the components (A) metronidazole and (B) fluflusulfuron alone, the synergistic effect of the present invention can provide one or more of many advantages. In particular, the application rate of the individual components can be significantly reduced while maintaining the high level of herbicidal efficacy of the two compounds. Compared with applying any one component alone, a composition containing two components can exhibit activity against a wide range of weeds. Further, a composition containing two components has the potential to control weed species at a lower application rate, and application of a single component alone is ineffective at the lower application rate. When these components are applied in combination, they can exhibit a greater speed of action than the individual components.

In the first aspect, the present invention provides a composition comprising herbicidal effective amounts of (A) methamphetamine and (B) fluflusulfuron-methyl.

As used herein, the term "herbicide" refers to a compound that exhibits activity for controlling plant growth. As used herein, the term "herbicidally effective amount" refers to the amount of this compound or combination of such compounds capable of controlling plant growth. The control effect includes all the differences from the natural development and growth of plants, including, for example, killing plants, retarding one or more aspects of plant development and growth, leaf scorch disease, albinism, stunting disease, etc.

As used herein, the term "plant" refers to all material parts of a plant, including buds, leaves, needles, stalks, stems, fruiting bodies, fruits, seeds, roots, tubers, and rhizomes.

As described above, the present invention relates to a synergistic herbicidal composition, which contains herbicidal effective amounts of (A) metronidazole and (B) fluflusulfuron to control undesired plant growth.

In other aspects, the present invention provides a method of controlling undesirable plants, the method comprising applying herbicidally effective amounts of (A) metronidazole and (B) fluflusulfuron to the plant or its locus.

In one embodiment, the method of the present invention uses the composition described above.

In yet another aspect, the present invention provides the use of a combination of metronidazole and fluflusulfuron to control the growth of plants at the location.

The composition and method of the present invention can be used to control undesirable plant growth in a range of crops, including grains, legumes, fiber plants, and vegetables. Control of undesirable plants in this type of crop can be achieved by applying appropriate amounts of metronidazole and fluflusulfuron to the plants to be controlled or their locus. The active compounds can be applied to the locus together or separately. If applied separately, the active compounds can be applied simultaneously and/or sequentially. The control method may include applying a herbicidal effective amount of the herbicidal composition to the plant or its locus.

The methods and compositions of the present invention can be used to control the growth of a series of different undesirable plants. The species range of (A) metabijing and (B) fluflusulfuron-methyl, that is, the species of weeds controlled by the corresponding compounds are broad and highly complementary.

However, it was surprisingly discovered that the combination of methamphetamine and fluflusulfuron-methyl exhibited a very significant synergistic effect in controlling many common weeds, including broadleaf weeds, grasses and sedges. , For example, Abutilon spp., Acalypha spp., Acanthospermum spp., Agrostemma spp., Alopecurus spp., Amaranthus spp., Ambrosia spp., Lynx (Amsinckia spp.), Anoda spp., Anthemis spp., Asperugo spp., Atriplex spp., Avena spp. , Boraginaceae spp., Brachiaria spp., Brassica spp., Bromus spp., Camelina spp., Camelina spp. (Capsella spp.), Cardamine spp., Cassia spp., Cenchrus spp., Cerastium spp., Chenopodium spp. , Chorispora spp., Claytonia spp., Conyza spp., Cyperus spp., Dactyloctenium spp., Dactyloctenium spp. Datura spp., Desmodium spp., Desmodium spp., Digitaria spp., Draba spp., Echinochloa spp. , Eleusine spp., Elymus spp., Eragrostis spp., Eriochloa spp., Eleusine spp., Eupatorium spp. Genus (Eupatorium spp.), Euphorbia spp., Fallopia spp., Fumaria spp., Galeopsis spp., Achyranthes (Galinsoga spp.), Galium spp., Geranium spp., Glebionis spp., Helianthus spp., Hibiscus spp. , Hordeum spp. , Ipomoea spp., Jacquemontia spp., Kochia spp., Lactuca spp., Lamium spp., Lepidium spp .), Leptochloa spp., Lithospermum spp., Lolium spp., Matricaria spp., Melochia spp., Lithospermum spp. Genus (Mercurialis spp.), Chestnut (Mollugo spp.), Myosotis spp., Oenothera spp., Oryza spp., Panicum spp., Poppy Genus (Papaver spp.), Persicaria spp., Poa spp., Polemonium spp., Polygonum spp., Portulaca spp. ), Ranunculus spp., Raphanus spp., Reseda spp., Richardia spp., Rumex spp., Senecio spp .), Sebania (Sesbania spp.), Setaria spp., Sida spp., Sinapis spp., Sisymbrium spp., Slda spp., Solanum spp., Sonchus spp., Sorghum spp. .), Spergula spp., Stellaria spp., Thlaspi spp., Trifolium spp., Triticum spp., Nettle ( Urtica spp., Vaccaria spp., Veronica spp., Vicia spp., Viola spp., and Xanthium spp. .

The combination of metbijing and fluflusulfuron-methyl is particularly effective in controlling the growth of the following plants: fluffy leaves ( Abutilon theophrasti ); Acalypha ostryifolia (Bristly Starbur, Acanthospermum hispidum ) Corncockle (Corncockle, Agrostemma githago ); Blackgrass, Alopecurus myosuroides (Blackgrass, Alopecurus myosuroides); Wild amaranth ( Amaranthus spp.); Pigweed (Common Ragweed, Ambrosia artemisiifolia ); Tarweed Fiddleneck, Amsinckia lycopsoides ); Spurred Anoda ( Anada cristata ); Stinky chamomile ( Anthemis cotula ); Pigsang (Asperugo procumbens ); Common Orache (Atriplex patula); Wild-Oat ( Avena fatua ); Wild Oat (Oats); Bugloss ( Boraginaceae ); Broadleaf Signal grass (brachial grass); Volunteer oilseed rape (Brassica napus); wild mustard (Brassica); flat brome (Rescuegrass, Bromus catharticus ); brome (Japanese brome, Bromus japonicus ); Hard brome (Ripgut brome, Bromus rigidus ); dry brome (Cheatgrass, Bromus tectorum ); small-seed camelina (camella); shepherd's purse ( Capsella bursa-pastoris ); cardamine (Bittercress, Cardamine) hirsuta ); Cassia (Sicklepod, Cassia obtusifolia ); Tribulus terrestris (Tribulus genus); Chickweed, curled ears (Mousear, Cerastium vulgatum ); Chenopodium album (Fat-hen, Chenopodium album); Grey vegetable (Tribulus genus); Ion Mustard (Blue mustard, Chorispora tene lla ); Miners lettuce (Claytonia perfoliata ); Horseweed Marestail ( Conyza canadensis ); Yellow nutsedge ( Cyperus esculentus ); Crowfootgrass ( Dactyloctenium aegedyptium); Datura stramonium ; Tansy mustard ( Descurainia pinnata ); Florida mountain locust ( Desmodium tortuosum ); Crabgrass (Crabgrass); Spring Spring whitlowgrass (Werner) (Werner); Jungleice (Bale-headed barnyard); Barnyardgrass ( Echinochloa crus-galli ); Goosegrass ( Eleusine indica ); Common creeping grass (Common couch) ( Elymus repens (Elymus repens)); Elymus repens (Elymus repens); Cupgrass (Southwestern wild millet); Redstem filaree (Elymus repens) Seedlings); Dogfennel ( Eupatorium capillifolium ); Sun spurge ( Eupatorium helioscopia ); Spotted Spurge (Euporbia maculata ); Black-bindweed ( Fallopia convolvulus ); Corydalis ( Hyssopus sylvestris); Petal flower ( Geranium); Hyssopia (Achyranthes); Cleavers (Galium aparine ); Geranium (Geranium); Geranium ( Geranium); Corn Marigold ( Glebionis segetum ); Sunflower (Helianthus); Wild watermelon seedlings (Venice Mallow, Hibiscus trionum ); Little barley (Little barley, Hordeum pusillum ); Ivy leaves Morning Glory (Ivyleaf morningqlorv) (Ban Zihua); Dent Morning Glory (White Star Potato); High Morning Glory (T all morningqlory (round leaf morning glory); small flower morning glory (Smallflower morningqlorv) (long-stemmed hairy house vine); Kochia (kochia); spiny lettuce (thorn lettuce); Lamium (Henbit dead-nettle, Lamium) amplexicaule ); Red deadnettle ( Lamium purpureum ); Virginia pepperweed ( Lepidium virginicum ); Lepidium virginicum; Carolina comfrey (Symphytum spp); Perennial rye (Perennial rye) -grass, Lolium perenne ); Pineappleweed (Matricaria discoidea); Redweed ( Melochia corchorifolia ); Annual mercury (Western mountain indigo) ; Chestnut rice grass (Light leaf chestnut rice grass); Field forget-me-not (Wild forget-me-not) (Myosotis arvensis) ; Split leaf evening primrose (Cutleaf Evening Primrose, Oenothera laciniata ); Red rice ( Oryza sativa )); Thatch ( Panicum cap/Hare ); Autumn millet (Foreign wild millet); Browntop Millet (Multi-branch millet); Texas panicum ( Panicum texanum ); Poppy (Poppy); Pale persicaria (Polygonum sorbus); Redshank ( Persicaria maculosa ); Annual meadow-grass (Annual meadow-grass); Bluegrass (Annual bluegrass); Bulbous bluegrass , Poa bulbosa); annual polemonium (Polemonium micranthum); Polemonium reptans (Jacob's Ladder, Polemonium reptans) ; creeping smartweed (Polygonum aviculare); wild buckwheat (wild buckwheat, Polygonum convolvulus); smartweed (Polygonum) (Polygonum spp .); Purslane (Purslane, Portulaca oleracea ); Ranunculus (Ranunculus) ( Ranunculus spp.); wild radish ( Raphanus raphanistrum ); wild mignonette (Mellow rhizome); Florida purslane (black clover); small sorrel (Sheep's sorrel, Rumex acetosella ); Senecio (Groundsel, Senecio ); Sesbania (Sesbania, Sesbania spp. ); Setaria spp. (Foxtails, Setaria spp.); Setaria viridis (Green foxtail, Setaria viridis ); Russian thistle ( Sinapis arvensis ); Sinapis arvensis (Charlock, Sinapis arvensis); Wind mustard (Tumble mustard) (Jim Hill) ( Sisymbrium altissimum ); Teaweed ( Slda spinosa ); Solanum nigrum (Black Nightshade, Solanum nigrum); Buffalobur (thorn Calyx Solanum ( Solanum rostratum ); Smooth Sonchus (Sonchus officinalis); Shattercane (Sorghum); False Sorghum (Seedloing Johnsongrass, Sorghum halepense ); Volunteer Sorghum (Sorghum); Corn spurrey, Spergula arvensis ); Chickweed (chickweed, Stellaria media ); Patrinia vulgaris (Thlaspi); Clover (Clovers, Trifolium ); Volunteer wheat (Triticum); Small nettle (Small nettle, Urtica urens ); Cowcockle (Wheat blue vegetable); Eyelashes Ivyleaf speedwell ( Veronica hederifolia ); Ivyleaf speedwell (Veronica hederifolia); Speedwells ( Veronica spp ); winter vetch (Vacilla vulgaris); cultivated tricolor pansy (wild viola); and Xanthium pensylvanicum (Xanthium pensylvanicum).

It has been found that the composition and method of the present invention are particularly suitable for controlling the growth of the following: Brassica; Amaranth; Monoflora; Capsicum; Datura; Crabgrass; Barnyard; Silli; Geranium Grass genus; Sesame genus; Phyllanthus genus; Brassica genus; Solanum genus; Stellaria genus;

Particularly, it has been found that the combination of (A) methamphetamine and (B) fluflusulfuron-methyl is effective in controlling the following items: Amaranthus, Amaranthus, Brassica napus, Shepherd's Purse, Datura, Sheng Crabgrass, Short-grained Crabgrass, Barnyardgrass, Barnyardgrass, Gooseweed, Geranium, Lamium, Onyx sesame, Stephanotis, Wild Mustard, Solanum, Chrysanthemum, Eyelash Granny, Pennsylvania Cocklebur.

, When used in combination or together, the synergistic effect of (A) metronidazole and (B) fluflusulfuron is demonstrated in a wide range of weight ratios of the two components. In the composition and method of the present invention, the weights of (A) methamphetamine and (B) fluflusulfuron are preferably at most 400:1, more preferably at most 200:1, still more preferably Is at most 150:1, still more preferably at most 100:1, And in many embodiments, a ratio of at most 70:1 is preferable. The weights of (A) methexine and (B) fluflusulfuron are preferably greater than 1:20, more preferably greater than 1:10, still more preferably greater than 1:5, still more Preferably, it is greater than 1:2, and a ratio of about 1:1 is suitable for many embodiments. The weight ratio of metronidazole and fluflusulfuron-methyl is preferably in the range of about 200:1 to about 1:1. Preferably, the weight ratio of (A) methamphetamine and (B) fluflusulfuron-methyl is from about 100:1 to about 1:1, more preferably from about 70:1 to about 2:1, Still more preferred is about 70:1 to about 5:1, and still more preferred is about 70:1 to about 10:1.

The active synergistic component may be present in the composition of the present invention in a wide range of amounts. In a preferred embodiment, the total amount of (A) methamphetamine and (B) fluflusulfuron-methyl accounts for about 5% to 99% of the weight of the composition, and more preferably accounts for about 5% to 99% of the weight of the composition. 10% to 80%, still more preferably 15% to 75% of the weight of the composition.

The amount of metronidazole present in the composition can account for 5% to 95% of the weight of the composition, more preferably 10% to 80% of the weight of the composition, and still more preferably 15% to 75% of the weight. Fluflusulfuron may be 0.01% to 50% by weight, preferably 0.05% to 20% by weight, still more preferably 0.1% to 10% by weight, still more preferably It is present in the composition in an amount of 0.1% to 5% by weight. In some embodiments of the present invention, the composition comprises 5% to 95% by weight of (A) metronidazole and 0.01% to 50% of (B) fluflusulfuron-methyl. Preferably, the composition contains 10% to 75% by weight of (A) metronidazole and 0.1% to 10% of (B) fluflusulfuron-methyl. More preferably, the composition contains 20% to 55% by weight of (A) metronidazole and 0.1% to 5% of (B) fluflusulfuron-methyl.

In general, the application rate of the active ingredients methamphetamine and fluflusulfuron-methyl depends on factors such as weed type, crop plant type, soil type, season, climate, soil ecology and various other factors. The application rate of the composition for a given set of conditions can be easily determined by routine experimentation.

Generally, the composition and method of the present invention can be applied according to the total amount of active ingredients (A) metronidazole and (B) fluflusulfuron from about 0.05 kg/ha (kg/ha) to about 2 kg/h. Application rate per hectare. Preferably, the application rate is from about 0.1 kg/ha to about 1.5 kg/ha of the total amount of active ingredients. Metronidazole can range from 10 g/ha to 1500 g/ha, more preferably from 100 g/ha to 1000 g/ha, and still more preferably from 200 g/ha. Apply at a ratio of g/ha to 600 g/ha. Fluflusulfuron may be in a ratio of from 1 g/ha to 500 g/ha, preferably from 1 g/ha to 100 g/ha, more preferably from 1 g/ha to 50 g/ha Come to apply. In some embodiments of the present invention, the application rate of the active ingredient is from 10 g/ha to 1500 g/ha (A) metronidazole and from 1 g/ha to 500 g/ha (B) flufenazur Sulfuron-methyl. Preferably, the application rate of the active ingredient is from 100 g/ha to 1000 g/ha for (A) metronidazole and 1 g/ha to 100 g/ha (B) fluflusulfuron-methyl. More preferably, the application rate of the active ingredient is from 200 g/ha to 600 g/ha of (A) metronidazole and 1 g/ha to 40 g/ha (B) fluflusulfuron-methyl.

As mentioned above, in the present invention, metronidazole and fluflusulfuron-methyl can be applied to plants and/or their locus separately or as a combination of part of a two-part herbicide system (such as the composition of the present invention) . When administered separately, metronidazole and fluflusulfuron may be administered simultaneously and/or sequentially.

The composition of the present invention can be formulated in a conventional manner, for example, by mixing metronidazole and fluflusulfuron with suitable adjuvants. The appropriate adjuvant will depend on factors such as the type of formulation and the end use. Suitable adjuvants are commercially available and known to those skilled in the art.

In particular, the composition may further include one or more additives selected from the following: fillers, carriers, solvents, surfactants, stabilizers, defoamers, antifreeze agents, preservatives, antioxidants, colorants, Thickener, solid adhesion agent, filler, wetting agent, dispersant, lubricant, anti-caking agent and diluent. Such adjuvants are known in the art and are commercially available. Their use in the formulation of the composition of the present invention will be clear to those of ordinary skill in the art.

Suitable formulations for administering the combination of metronidazole and fluflusulfuron and the composition of the present invention include solution (SL), emulsion (EC), water-based emulsion (EW), microemulsion (ME), water Suspension (SC), oil-based water suspension (OD), flowable suspension (FS), water dispersible granules (WG), water-soluble granules (SG), wettable powder (WP), water-soluble Powder (SP), granules (GR), capsule granules (CG), fine granules (FG), large granules (GG), concentrated emulsion (SE), capsule suspension (CS) and microgranules (MG) ).

The preferred type of formulation for the composition of the present invention is water suspension (SC), water Dispersible granules (WG), water-soluble granules (SG) and wettable powder (WP).

The composition may contain one or more inert fillers. Such inert fillers are known in the art and are commercially available. Suitable fillers include, for example, natural ground minerals, such as kaolin, alumina, talc, chalk, quartz, attapulgite, montmorillonite, and diatomaceous earth; or synthetic ground minerals, such as highly dispersed silicic acid, alumina , Silicate, and calcium phosphate and dibasic calcium phosphate. Suitable inert fillers for particles include, for example, crushed and classified natural minerals (such as calcite, marble, pumice, sepiolite, and dolomite), or synthetic particles of inorganic and organic abrasive materials, as well as particles of organic materials (such as Sawdust, coconut husks, corn cobs, and tobacco stems).

The composition may contain one or more surfactants, and the one or more surfactants are preferably nonionic, cationic and/or anionic in nature, and have good emulsification, dispersion and moisturizing properties. The wet characteristics of the surfactant mixture depend on the active compound/compounds to be formulated. Suitable surfactants are known in the art and are commercially available.

Suitable anionic surfactants can be both so-called water-soluble soaps and water-soluble synthetic surface-active compounds. Usable soaps include substituted or unsubstituted ammonium salts of alkali metals, alkaline earth metals or higher fatty acids (C ₁₀ -C ₂₂ ), for example, sodium or potassium oleic acid or stearic acid, or The sodium or potassium salt of a mixture of natural fatty acids.

The surfactant system may contain ionic or non-ionic emulsifiers, dispersants or wetting agents. Examples of such surfactants include polyacrylates, lignosulfonates, benzenesulfonates or naphthalenesulfonates, polycondensates of ethylene oxide and fatty alcohols or fatty acids or fatty amines, substituted phenols (especially These are alkyl phenols), sulfosuccinate salts, taurine derivatives (especially alkyl esters of taurine) and polyethoxylated phenols or phosphate esters of alcohols.

When the active compound and/or inert carrier and/or adjuvant/adjuvant are not dissolved in water and are used in the final application of the composition, the presence of at least one surfactant is usually required.

The composition optionally further contains one or more polymer stabilizers. Suitable polymer stabilizers that can be used in the present invention include, but are not limited to: polypropylene, polyisobutylene, polyisoprene, copolymers of monoolefins and diolefins, polyacrylates, polystyrene, polyacetic acid Vinyl ester, polyurethane or polyamide. Suitable stabilizers are known in the art and are commercially available.

It is generally believed that the above-mentioned surfactants and polymer stabilizers impart stability to the composition, thereby allowing the composition to be formulated, stored, transported, and applied.

Suitable defoamers include all substances that can normally be used for this purpose in agrochemical compositions. Suitable defoamers are known in the art and are commercially available. A particularly preferred defoamer is a mixture of polydimethylsiloxane and perfluoroalkyl phosphoric acid, such as a silicone defoamer commercially available from GE or Compton.

The suitable solvent contained in the composition can be selected from all conventional organic solvents that thoroughly dissolve the active compounds metronidazole and fluflusulfuron. In addition, suitable organic solvents for metronidazole and fluflusulfuron are known in the art. The following mentioned solvents can be considered as preferred: N-methylpyrrolidone, N-octylpyrrolidone, cyclohexyl-1-pyrrolidone; or paraffinic hydrocarbons, isoparaffinic hydrocarbons, cycloparaffinic hydrocarbons and A mixture of aromatic hydrocarbons, such as SOLVESSO ^TM 200. Suitable solvents are commercially available.

Suitable preservatives for the composition of the present invention include all substances that can normally be used for this purpose in this type of agrochemical composition, and are also well known in the art. Suitable examples that may be mentioned include the commercially available preservatives PREVENTOL® (from Bayer AG) and PROXEL® (Bayer).

Suitable antioxidants for use in the composition of the present invention are all substances that can normally be used for this purpose in agrochemical compositions as known in the art. Preferred is butylated hydroxytoluene.

Suitable thickeners used in the composition include all substances normally used for this purpose in agrochemical compositions, such as xanthan gum, PVOH, cellulose and its derivatives, clay hydrated silicate, silica Magnesium aluminum acid or mixtures thereof. Again, such thickeners are known in the art and are commercially available.

The composition may further include one or more solid adhesives. Such adhesives are known in the art and are commercially available. They include organic binders, including tackifiers such as cellulose or substituted cellulose, natural and synthetic polymers in powder, granule, or latex form, and inorganic binders such as gypsum, silicon Stone or cement.

In the methods and uses of the present invention, the combination of the active ingredients metronidazole and fluflusulfuron-methyl can be applied to plants by any appropriate method, such as applied to the leaves of plants and/or their locations where they need to be controlled, Such as the surrounding soil. "Location" refers to the place where the plant grows, the place where the plant propagation material is sown, or the place where the plant propagation material is to be sown.

As mentioned above, the present invention also relates to the use of the combination of metronidazole and fluflusulfuron in, for example, the above-mentioned composition or formulation for controlling or modifying undesired plant growth in crops. The combination of metronidazole and fluflusulfuron-methyl is suitable for the treatment of a range of crops, including grains such as wheat, barley, rye, oats, corn, rice, sorghum, triticale and related crops; sugar beets, such as sugar beets and Forage beets; fruits such as pears, stone fruits, and soft fruits (such as apples, grapes, pears, plums, peaches, almonds, cherries, and berries (such as strawberries, raspberries, and blackberries)); legumes, such as beans, lentils , Peas, soybeans, and peanuts; oil plants, such as rape, mustard, and sunflower; Cucurbitaceae, such as zucchini, cucumber, and melon; fiber plants, such as cotton, flax, hemp, and jute; citrus fruits, such as orange, lemon, and grapefruit And citrus; vegetables such as spinach, lettuce, asparagus, cabbage, carrots, onions, tomatoes, potatoes and red peppers; ornamental plants such as flowers, shrubs, broad-leaved trees and evergreen trees (such as conifers) and sugar cane.

In a preferred embodiment, the method or composition of the present invention is used to control undesirable plant growth in grains, legumes, fiber plants and vegetables, preferably to control wheat, barley, rye, oats, Corn, rice, sorghum, triticale, beans, lentils, peas, soybeans and peanuts, cotton, flax, hemp, jute, spinach, lettuce, asparagus, cabbage, carrots, onions, tomatoes, potatoes and red peppers, more preferably It is undesirable plant growth in wheat, barley, corn, rice, soybeans, cotton, tomatoes and potatoes.

Suitable crops that can be treated include those that are tolerant to metronidazole and fluflusulfuron. The tolerance may be natural tolerance produced by selective breeding, or it may be artificially introduced by genetic modification of crop plants. In this respect,'tolerance' means less sensitivity to damage caused by one or more specific herbicides (in this case, metronidazole and fluflusulfuron).

The active ingredients used in the practice of the present invention can be administered in various concentrations in a variety of ways known to those skilled in the art. The methods and compositions of the present invention can be used to control undesired plant growth by applying active ingredients to plants and/or their locations before planting, before germination and/or after germination.

The active ingredients metronidazole and fluflusulfuron can be applied to undesired plants and crops to be protected and/or their locations by conventional methods, such as coating, spraying, spraying, dipping, Soaking, injection, irrigation, etc.

The method of the present invention can use other pesticides except the combination of metronidazole and fluflusulfuron. For example, the composition of the present invention may contain or be mixed with other pesticides (such as fungicides, insecticides and nematicides), growth factor enhancers and fertilizers to enhance the treatment activity of the present invention or expand its activity range. Similarly, the method of the present invention can be used in combination with one or more of the aforementioned active ingredients to obtain enhanced efficacy or a wider range of activities again.

Now, the embodiments of the present invention will be described with the following examples for illustrative purposes only.

Percentages are percentages by weight, unless otherwise specified.

Instance

Examples of formulations

Prepare water dispersible granules (WG) by the following method: under compressed air, mix and grind the active ingredients and additives (0.5% SUPRALATE® (sodium lauryl sulfate, Witco Inc.), Green Greenwich), 5% REAX®88B (sodium lignosulfonate, Westvaco Corp), potassium carbonate (balanced to 100%)), then soaked, extruded and dried to obtain Water-dispersible granules.

100% For example, a water-dispersible granule (WG) formulation is prepared from the following components:

100%

By mixing finely ground active ingredients and additives (10% propylene glycol, 5% tristyryl phenol ethoxylate, 1% sodium lignosulfonate, 1% carboxymethyl cellulose, 1% silicone oil (75%) Water emulsion form), 0.1% xanthan gum, 0.1% NIPACIDE BIT 20, water (balance to 1L) to prepare a water suspension (SC).

For example, an aqueous suspension (SC) formulation is prepared from the following components:

Prepare water-soluble granules (SG) by the following method: under compressed air, mix and grind the active ingredients and additives (0.5% SUPRALATE® (sodium lauryl sulfate, Vitco, Greenwich), 5% REAX®88B (sodium lignosulfonate, Versvac), 2% sodium bicarbonate (NaHCO ₃ ), potassium sulfate (balanced to 100%)), then soaked, extruded and dried to obtain water-soluble granules Agent.

For example, a water-soluble granule (SG) formulation is prepared from the following components:

The wettable powder (WP) formulation was prepared by mixing and grinding the active ingredients and additives (5% DISPERSOGEN®1494; 8% SIPERNAT®622S, kaolin (balanced to 100g) under compressed air).

For example, a wettable powder (WP) formulation is prepared from the following components:

A series of formulation examples 1 to 9 were prepared according to the method described above. The type of formulation and active ingredient content are summarized in Table A below.

Examples 1 and 2 are comparative examples.

Biological examples

When the combined activity of the two active compounds is greater than the sum of the activities of the two active compounds administered alone, the combination of the two active compounds exhibits a synergistic effect.

The expected activity of a given combination of two active compounds can be calculated by the so-called "Colby formula" (see SR Colby (Colby), "Calculating the Synergistic and Antagonistic Responses of Herbicide Combinations (Calculating Synergistic and Antagonistic Responses of Herbicide Combinations)", Weeds (1967, 15, 20-22): By virtue of: E=A+B-(A×B/100)

Where: A=when active compound A is used at an application rate of m g/ha, the activity percentage of compound A; B=when active compound B is used at an application rate of n g/ha, the activity percentage of compound B; E= The estimated percentage of activity when compounds A and B are used together at an application rate of m g/ha and n g/ha.

If the actual activity observed for the combination of compounds A and B is greater than the activity calculated using the above formula, then the combined activity is superadditive, that is, there is a synergistic effect.

Biological example 1

Sow wheat, barley, and corn plants in randomized blocks of the field. There are different types of weeds, and their relative density in each block is identified and listed in Table 1 below.

The compositions according to Examples 1 to 9 were applied by spraying 50 days after planting. After spraying, each block was kept for about 2 weeks.

After two weeks of application, each plot was inspected to determine the effectiveness of each formulation in controlling the growth of weeds. The results are set forth in Table 2 below.

The effectiveness of the treatment in controlling the growth of weeds is expressed as the percentage of weeds killed after the treatment.

It can be seen from the results set forth in Table 2 that compared with the effects predicted by the combination of metronidazole and fluoxuron-methyl alone or from the combination of the two active ingredients, the present invention comprising metronidazole and fluflusulfuron-methyl The combination of formulations showed a significant increase in the control of target weeds. This increased effect clearly shows the synergy between the two active ingredients.

Biology example 2

Sow soybeans and cotton plants in randomized blocks of the field. There are different types of weeds, and their relative density in each block is identified and listed in Table 3 below.

The compositions according to Examples 1 to 9 were applied by spraying 50 days after planting. After spraying, each block was kept for about 2 weeks.

After two weeks of application, each plot was inspected to determine the effectiveness of each formulation in controlling the growth of weeds. The results are set forth in Table 4 below.

The effectiveness of the treatment in controlling the growth of weeds is expressed as the percentage of weeds killed after the treatment.

From the results set forth in Table 4 above, it can be seen that compared with the effects predicted by the combination of metronidazole and fluoxuron alone or from the combination of the two active ingredients, the present invention comprising metronidazole and fluflusulfuron Longon's combined formulation showed a significant increase in the control of target weeds. This increased effect clearly shows the synergy between the two active ingredients.

Biology example 3

Sow tomato and potato plants in randomized blocks of the field. There are different types of weeds, and their relative density in each block is identified and listed in Table 5 below.

The compositions according to Examples 1 to 9 were applied by spraying 50 days after planting. After spraying, each block was kept for about 2 weeks.

After two weeks of application, each plot was inspected to determine the effectiveness of each formulation in controlling the growth of weeds. The results are set forth in Table 6 below.

The effectiveness of the treatment in controlling the growth of weeds is expressed as the percentage of weeds killed after the treatment.

As can be seen from the results set forth in Table 6, compared with the effects predicted by the combination of metronidazole and flufensulfuron-methyl alone or from the combination of the two active ingredients, the present invention comprising metronidazole and fluflusulfuron-methyl The combination of formulations showed a significant increase in the control of target weeds. This increased effect clearly shows the synergy between the two active ingredients.

Biology example 4

Sow rice in randomized blocks of the field. There are different types of weeds, and their relative density in each block is identified and listed in Table 7 below.

The compositions according to Examples 1 to 9 were applied by spraying 50 days after planting. After spraying, each block was kept for about 2 weeks.

After two weeks of application, each plot was inspected to determine the effectiveness of each formulation in controlling the growth of weeds. The results are set forth in Table 8 below.

The effectiveness of the treatment in controlling the growth of weeds is expressed as the percentage of weeds killed after the treatment.

It can be seen from the results set forth in Table 8 that compared with the effects predicted by the combination of metronidazole and fluoxsulfuron alone or from the combination of the two active ingredients, the present invention comprising metronidazole and fluflusulfuron The combination of formulations showed a significant increase in the control of target weeds. This increased effect clearly shows the synergy between the two active ingredients.

Claims (35)

A composition comprising a herbicidal effective amount of (A) metronidazole and (B) fluoxuron-methyl, wherein the weight ratio of metronidazole to fluoxuron-methyl is at most 400:1. For the composition described in item 1 of the scope of patent application, the weight ratio of metronidazole to fluflusulfuron-methyl is at most 200:1. For the composition described in item 2 of the scope of the patent application, the weight ratio of metronidazole to fluoxuron-methyl is from 200:1 to 1:1. For the composition described in item 3 of the scope of the patent application, the weight ratio of metronidazole to fluflusulfuron-methyl is in the range from 70:1 to 10:1. The composition according to any one of items 1 to 4 in the scope of the patent application, wherein the total amount of metronidazole and fluflusulfuron accounted for 5% to 99% of the weight of the composition. The composition described in any one of items 1 to 4 in the scope of the patent application, wherein metronidazole is present in an amount of from 5% to 95% by weight. The composition according to any one of items 1 to 4 in the scope of the patent application, wherein fluflusulfuron-methyl is present in an amount of from 0.01% to 50% by weight. The composition according to item 7 of the scope of the patent application, wherein the composition contains 10% to 75% by weight of metronidazole and 0.1% to 10% by weight of fluflusulfuron-methyl. For the composition described in any one of items 1 to 4 in the scope of the patent application, the composition further comprises one or more additives selected from the following: fillers, carriers, solvents, surfactants, stabilizers, Defoamers, antifreeze agents, preservatives, antioxidants, colorants, thickeners, solid adhesives, fillers, wetting agents, dispersants, lubricants, anti-caking agents and diluents. The composition described in any one of items 1 to 4 in the scope of the patent application, the composition is formulated as a solution (SL), emulsion (EC), water-based emulsion (EW), microemulsion (ME), water suspension Agent (SC), oil-based aqueous suspension (OD), flowable suspension (FS), water dispersible granules (WG), water-soluble granules (SG), wettable powder (WP), water-soluble powder (SP), granules (GR), capsule granules (CG), fine granules (FG), Large granules (GG), concentrated emulsion (SE), capsule suspension (CS) or microgranules (MG). A method for controlling undesirable plant growth, which comprises applying herbicidal effective amounts of (A) metronidazole and (B) fluoxysulfuron to the plant or its locus, wherein the applied metronidazole and fluoxysulfuron The weight ratio is up to 400:1. The method described in item 11 of the scope of patent application, wherein the undesired plant growth is controlled in crops including grains, legumes, fiber plants and vegetables. The method described in item 12 of the scope of patent application, wherein the controlled plant growth is one or more of broadleaf grass, grasses and sedges. The method according to any one of items 11 to 13 in the scope of the patent application, wherein the controlled plant growth is one or more of the following: Brassica; Amaranth; Monoflower; Capsicum; Datura; Crabgrass; Barnyard; Fructus; Geranium; Wild sesame; Stephanotis; Brassica; Solanum; Stellaria; Granny; Xanthium. The method described in item 14 of the scope of patent application, wherein the controlled plant growth is one or more of the following: amaranth, scallop, brassica napus, shepherd’s purse, datura, ascending crabgrass, Crabgrass, Barnyardgrass, Barnyardgrass, Goosegrass, Geranium, Lavender, Onyx sesame, Stephanotis, Wild mustard, Solanum, Chickweed, Eyelash Granny, Pennsylvania Cocklebur. The method described in any one of items 11 to 13 in the scope of the patent application, wherein the total amount of the active ingredients of metronidazole and fluflusulfuron is from 0.05 kg/ha (kg/ha) to 2 g/ha The application rate is applied. The method described in item 16 of the scope of the patent application, wherein the total amount of the active ingredients metronidazole and flufensulfuron-methyl are applied at an application rate of from 0.1 g/ha to 1.5 g/ha. The method described in any one of items 11 to 13 in the scope of the patent application, wherein metronidazole is applied at an application rate of from 10 g/ha to 1500 g/ha. Such as the method described in item 18 of the scope of patent application, in which metronidazole is reduced from 100 Application rate of g/ha to 1000 g/ha. The method according to any one of items 11 to 13 in the scope of the patent application, wherein fluflusulfuron-methyl is applied at an application rate of from 1 g/ha to 500 g/ha. The method described in item 20 of the scope of patent application, wherein fluflusulfuron-methyl is applied at an application rate of from 1 g/ha to 100 g/ha. The method according to any one of items 11 to 13 in the scope of the patent application, wherein the component (A) and the component (B) are applied before planting, before germination and/or after germination. The method according to any one of items 11 to 13 in the scope of the patent application, wherein metronidazole and fluflusulfuron are simultaneously applied to the location. The method described in item 23 of the scope of patent application, wherein the composition described in any one of items 1 to 10 of the scope of patent application is used. The method according to any one of items 11 to 13 in the scope of patent application, wherein metronidazole and fluflusulfuron are applied to the location successively. The method described in item 11 of the scope of patent application, wherein the weight ratio of metronidazole to fluflusulfuron-methyl is up to 200:1. The method according to any one of items 11 to 13 in the scope of the patent application, wherein the weight ratio of metronidazole to fluflusulfuron-methyl is from 200:1 to 1:1. For the method described in item 27 of the scope of the patent application, the weight ratio of metronidazole to fluflusulfuron-methyl is in the range from 70:1 to 10:1. The method described in any one of items 11 to 13 of the scope of the patent application, wherein the application rate of the total amount of the active ingredients metrobiquin and fluflusulfuron is from 0.05 g/ha (kg/ha) to 2 kg/ha. Such as the method described in item 29 of the scope of the patent application, wherein the application rate of the total amount of the active ingredients metronidazole and flufensulfuron-methyl is from 0.1 kg/ha (kg/ha kg/ha) to 1.5 kg/ Hectares. The method described in any one of items 11 to 13 in the scope of the patent application, wherein metronidazole is applied at an application rate of from 10 g/ha to 1500 g/ha. The method described in item 31 of the scope of the patent application, wherein metronidazole is applied at an application rate of from 100 g/ha to 1000 g/ha. The method according to any one of items 11 to 13 in the scope of the patent application, wherein fluflusulfuron-methyl is applied at an application rate of from 1 g/ha to 500 g/ha. The method described in item 33 of the scope of the patent application, wherein fluflusulfuron-methyl is applied at an application rate of from 1 g/ha to 100 g/ha. The use of a combination of metronidazole and flufensulfuron-methyl for controlling the growth of plants in the locality, wherein the weight ratio of metrobiquin and fluflusulfuron-methyl applied is up to 400:1.