TW201725988A - Herbicidal composition and method for controlling plant growth - Google Patents

Abstract

A synergistic herbicidal composition is provided, the composition comprising a herbicidally effective amount of (A) metribuzin and (B) flupyrsulfuron. A method of controlling plant growth at a locus comprises applying to the locus herbicidally effective amounts of both metribuzin and flupyrsulfuron.

Description

Herbicide composition and method for controlling plant growth

The present invention relates to a herbicidal composition. The invention also relates to a method of controlling undesired plant growth and in particular undesirable plant growth in a crop, the method comprising the use of the aforementioned composition.

Undesirable plants inhibit crop growth and protect crops from undesired plant inhibition in long-term problems in agriculture. To solve this problem, researchers have attempted to develop a wide range of chemicals and chemical formulations that can effectively control this undesirable plant growth. Many types of chemical herbicides have been disclosed in the literature, and a large number of chemical herbicides are in commercial use.

It has been demonstrated that some herbicidal active ingredients are more effective when administered in combination than alone. This effect is called "synergy." According to the Herbicide Handbook of the Weed Science Society of America, Seventh Edition, 1994, p. 318, "synergy" is the interaction of two or more factors, making The effect when combined is greater than the effect predicted based on the response to each of the factors administered alone.

It is known that metribuzin and flupyrsulfuron are two herbicidal compounds and are used to control undesired plant growth. Both chlorhexidine and flufensulfuron are disclosed in The Pesticides Manual, The British Crop Protection Council. Twelfth Edition, 2000. Both compounds are also commercially available in a range of compositions.

灭必净 (IUPAC name: 4-amino-6-tertiary butyl-4,5-dihydro-3-methylthio-1,2,4-three -5-keto); 4-amino-6-tertiary butyl-3-methylthio-1,2,4-tri -5(4H)-one has the following chemical structure:

An inhibitor of photosynthesis in the plant. The compound can be absorbed by the roots and leaves of the plant and then transferred to the xylem. Extinction can effectively control grasses and broadleaf weeds. The chlorhexidine system is commercially available in herbicidal compositions and methods for its preparation are known in the art.

Flunarsulfuron sodium (IUPAC name: methyl 2-(4,6-dimethoxypyrimidin-2-ylaminocarbamoylsulfonyl)-6-trifluoromethylnicotinate monosodium Salt) has the following chemical structure:

Fluroxypyrimsulfuron sodium is commercially available and methods for its preparation are known in the art. Fluroxypyrimsulfuron sodium is a branched chain amino acid synthesis (ALS) inhibitor. The compound acts by inhibiting the biosynthesis of the essential amino acid proline and isoleucine, thereby stopping cell division and plant growth of the plant.

Most surprisingly, it has now been found that chlorhexidine and flufensulfuron show synergy in controlling plant growth when applied in combination, for example in a composition comprising two compounds or when applied separately to the treatment to be treated. At the time of the location.

The synergy of the present invention provides one or more of a number of advantages over the use of component (A) chlorhexidine alone and (B) flufensulfuron alone. In particular, the application rate of the individual components can be significantly reduced while maintaining a high level of herbicidal efficacy of both compounds. A composition comprising both components exhibits activity over a relatively broad range of weeds as compared to the application of either component alone. Further, a composition comprising two components has the potential to control weed species at a lower application rate, while application of the individual components alone at this lower application rate is ineffective. When the components are applied in combination, they may exhibit a greater rate of action than the individual components.

In a first aspect, the invention provides a composition comprising a herbicidally effective amount of (A) chlorhexidine and (B) flufensulfuron.

As used herein, the term "herbicide" refers to a compound that exhibits activity in controlling the growth of a plant. As used herein, the term "herbicidally effective amount" refers to an amount of such a compound or combination of such compounds that is capable of exerting a controlling effect on plant growth. Control effects include all differences from the natural development and growth of plants, including, for example, killing plants, retarding one or more aspects of plant development and growth, leaf coke, albinism, dwarf disease, and the like.

As used herein, the term "plant" refers to all parts of a plant, including buds, leaves, needles, stalks, stems, fruiting bodies, fruits, seeds, roots, tubers, and rhizomes.

As indicated above, the present invention relates to a synergistic herbicidal composition comprising a herbicidally effective amount of (A) chlorhexidine and (B) flufensulfuron to control undesirable plant growth.

In other aspects, the invention provides a method of controlling an undesirable plant, the method comprising applying a herbicidally effective amount of (A) chlorhexidine and (B) flufensulfuron to the plant or its locus.

In one embodiment, the method of the invention employs the above composition.

In still a further aspect, the invention provides the use of a combination of chlorhexidine and flufensulfuron in controlling the growth of a plant in a locus.

The compositions and methods of the present invention can be used to control undesirable plant growth in a range of crops including cereals, legumes, fiber plants, and vegetables. Controlling undesirable plants in such crops can be achieved by applying an appropriate amount of chlorhexidine and flurazine to the plants to be controlled or their locus. The active compounds can be applied to the locus together or separately. If administered separately, the active compound can be administered simultaneously and/or sequentially. The method of controlling can include applying a herbicidally effective amount of the herbicidal composition to the plant or its locus.

The methods and compositions of the present invention can be used to control a range of different undesirable plant growth. (A) The range of species of chlorhexidine and (B) fluridine, ie the weed species controlled by the corresponding compounds are broad and highly complementary.

Surprisingly, however, it has been found that the combination of chlorhexidine and flufensulfuron exhibits a very significant synergistic effect in controlling many common weeds including broadleaf weeds, grasses and sedges. For example, Abutilon spp., Acalypha spp., Acanthospermum spp., Agrostemma spp., Alopecurus spp., Amaranthus spp., Ambrosia spp., Pleurotus (Amsinckia spp.), Anoda spp., Anthemis spp., Asperugo spp., Atriplex spp., Avena spp. , Boraginaceae spp., Brachiaria spp., Brassica spp., Bromus spp., Camelina spp., genus (Capsella spp.), Cardamine spp., Cassia spp., Cenchrus spp., Cerastium spp., Chenopodium spp. , Chorispora spp., Claytonia spp., Conyza spp., Cyperus spp., Dactyloctenium spp., Datura Datura spp.), Descurainia spp., Desmodium spp., Digitaria spp., Draba spp., Echinochloa spp. , Eleusine spp., Elymus spp .), Eragrostis spp., Eriochloa spp., Erodium spp., Eupatorium spp., Euphorbia spp. Fallopia spp., Fumaria spp., Galeopsis spp., Galinsoga spp., Galium spp. Geranium spp., Glebionis spp., Helianthus spp., Hibiscus spp., Hordeum spp., Ipomoea spp. , Jacquemontia spp., Kochia spp., Lactuca spp., Lamium spp., Lepidium spp., Leptochloa Spp.), Lithospermum spp., Lolium spp., Matricaria spp., Melochia spp., Mercurialis spp., chestnut Mollugo spp., Myosotis spp., Oenothera spp., Oryza spp., Panicum spp., Papaver spp., spring Persicaria spp., Poa ( Poa spp.), Polemonium spp., Polygonum spp., Portulaca spp., Ranunculus spp., Raphanus spp., M. Genus (Reseda spp.), genus Richardia spp., Rumex spp., Senecio spp., Sesbania spp., Setaria spp. Sida spp., Sinapis spp., Sisymbrium spp., Slda spp., Solanum spp., Sonchus spp., Sorghum spp .), Spergula spp., Stellaria spp., Thlaspi spp., Trifolium spp., Triticum spp., Castor Urtica spp.), Vaccaria spp., Veronica spp., Vicia spp., Viola spp., and Xanthium spp. .

The combination of chlorhexidine and flufensulfuron is particularly effective in controlling the growth of the following plants: Abutilon theophrasti ; Acalypha ostryifolia ; Bristly Starbur, Acanthospermum hispidum ;Corncockle, Agrostemma githago ; Blackgrass, Alopecurus myosuroides ; Amaranthus spp.; Common Ragweed, Ambrosia artemisiifolia ; Tarweed Fiddleneck, Amsinckia lycopsoides ); Spurred Anoda ( Anada cristata ); Chamomile ( Anthemis cotula ); Poria ( Asperugo procumbens ); Common Orache (Atriplex patula); Wild-Oat, Avena fatua ; Wild oats (Oats); Betula ( Boraginaceae ); Broadleaf Signal grass (arm-shaped grass); Volunteer oilseed rape (Brassica napus L.); Wild mustard (Amaranthus); Rescuegrass, Bromus catharticus ; Japanese brome, Bromus japonic us); hard brome (Ripgut brome, Bromus rigidus); downy brome (Cheatgrass, Bromus tectorum); small seed false flax (small fruit camelina); shepherd's purse (Shepherd's purse, Capsella bursa- pastoris); Cardamine ( Bittercress, Cardamine hirsuta ); Cassia (Sicklepod, Cassia obtusifolia ); Valerian (Herbaceae); Traditional, Mousear, Cerastium vulgatum ; Fat-hen, Chenopodium album ; ); I mustard (Blue mustard, Chorispora tenella ); Miners lettuce, Claytonia perfoliata ; Horseweed Marestail, Conyza canadensis ; Yellow sedge ( Cyperus esculentus ); Crowfootgrass , Dactyloctenium aegyptium ); Mandala (Jimsonweed, Datura stramonium ); Tansy mustard ( Descurainia pinnata ); Florida mountain grasshopper ( Desmodium tortuosum ); Crabgrass); Spring whitlowgrass (Warner) (Venard); Jungleric (Break); Barnyard Grass, Echinochloa crus-galli ); Goosegrass ( Eleusine indica ); Common couch ( Elymus repens ); Large Teff (Teffea); Cupgrass (Southwestern wild donkey); Redstem filaree (Cinnamon yak seedlings); Dogfennel, Eupatorium capillifolium ; Sun spurge, Euphorbia helioscopia ; Spotted Spurge , Euphorbia maculata ); Black-bindweed, Fallopia convolvulus ; Fusarium (Calendula officinalis); Petal flower (Cygnus); Achyranthes (Achyranthes); (Cleavers, Galium aparine ); geranium (geranium); geranium (geranium); corn Marigold ( Glebionis segetum ); sunflower (Helianthus); wild watermelon Seed Mallow ( Hibiscus trionum ); Little barley ( Hordeum pusillum ); Ivyleaf morningqlorv (bowl flower); Dent morning glory (white star); Tall morningqlory (Tall morningqlory) Round leaf glory; small flower glory (Smallflower morni Ngqlorv) (L. sylvestris); genus genus (skin); thorny lettuce (Hanbit dead-nettle, Lamium amplexicaule ); red deadnettle, Lamium purpureum ; Virginia pepperweed ( Lepidium virginicum ); Thousands of genus (Golden genus); Carolina comfrey (Purple); perennial rye-grass, Lolium perenne ; Pineappleweed (Matricaria discoidea); Redweed ( Melochia corchorifolia ); Mountain blue (Western hawthorn); Licorice (light leaf chestnut); forget-me-not Field forget-me-not (Myosotis arvensis) ; Cutleaf Evening Primrose ( Oenothera laciniata ); Red rice ( Oryza sativa ); Thatch ( Panicum cap/Hare ); Autumn子(洋野黍); Browntop Millet (Multiple Branch); Texas Panicum ( Panicum texanum ); Poppy Flower ( 虞美人 ); Pale persicaria ( 酸型叶蓼); spring Polygonum (Redshank, Persicaria maculosa); precocious (Annual meadow-grass) (annual bluegrass); bluegrass (Poa annua); Poa bulbosa (Bulbous bluegrass, Poa bulbosa); annual polemonium (Polemonium micranthum); Polemonium reptans (Jacob's Ladder, Polemonium reptans) ;匍匐蓼 (萹); wild buckwheat, Polygonum convolvulus ; Polygonum spp.; Purslane, Portulaca oleracea ; Ranunculus spp.; Raphanus raphanistrum ; wild sylvestris (yellow sylvestris); Florida purslane; ink sorrel (Sheep's sorrel, Rumex acetosella ); senecio ( Senecio ); genus (Sesbania, Sesbania) Spp . ); Foxtails, Setaria spp .; Green foxtail ( Setaria viridis ); Russian cockroach (Golden noon flower); Charlock, Sinapis arvensis ; Tumble mustard (Jim Hill) ( Sisymbrium altissimum ); Teaweed ( Sida spinosa ); Black Nightshade, Solanum nigrum ; Buffalobu r) ( Solanum rostratum ); smoothing sauerkraut (chicory); Shattercane (sorghum halepense ); sorghum sorghum (sorghum halepense ); sorghum sorghum (sorghum genus); Spurrey, Spergula arvensis ); chickweed, Stellaria media ; sage (Clovers, Trifolium ); authigenic wheat (Triticum); small nettle (Small nettle, Urtica urens ); Cowcockle Dish); Ivyleaf speedwell, Veronica hederifolia ; Speedwells, Veronica spp ; Winter pea (Viburnum pea); Cultivated Pansy (wild leeks); and Xanthium pensylvanicum ).

It has been found that the compositions and methods of the present invention are particularly useful for controlling the growth of: genus; genus; genus, genus, genus, genus, genus, genus, genus, genus, genus Genus; wild sesame; genus of genus; genus of white genus; Solanum; genus of genus; genus of genus;

In particular, it has been found that the combination of (A) chlorhexidine and (B) flufensulfuron is effective in controlling the following: genus, genus, malachite, amaranth, mandala, liter Matang, Xiaoying Matang, Bald Donkey, Valerian, Goosegrass, Geranium, Baogai, Xiaoye Sesame, Thousands of Gold, Wild European White Mustard, Solanum nigrum, Fanzhi, Eyelash Po Na, Pennsylvania Xanthium.

When used in combination or together, the synergistic effect of (A) chlorhexidine and (B) fluridine is exhibited in a wide range of weight ratios of the two components. In the composition and method of the present invention, the weight of (A) chlorhexidine and (B) flufensulfuron is preferably at most 400:1, more preferably at most 200:1, still more preferably. It is at most 150:1, still more preferably at most 100:1, And in many embodiments a ratio of at most 70:1 is preferred. The weight of (A) chlorhexidine and (B) fluridine is preferably greater than 1:20, more preferably greater than 1:10, still more preferably greater than 1:5, still more Preferably, the ratio is greater than 1:2, and a ratio of about 1:1 is suitable for many embodiments. Preferably, the weight of chlorhexidine and flufensulfuron is in the range of from about 200:1 to about 1:1. Preferably, the weight ratio of (A) chlorhexidine to (B) flufensulfuron is from about 100:1 to about 1:1, more preferably from about 70:1 to about 2:1, Still more preferably from about 70:1 to about 5:1, still more preferably from about 70:1 to about 10:1.

The active synergistic component can be present in the compositions of the present invention in a wide range of amounts. In a preferred embodiment, the total amount of (A) chlorhexidine and (B) flurazepam is from about 5% to 99% by weight of the composition, more preferably the weight of the composition. From 10% to 80%, still more preferably from 15% to 75% by weight of the composition.

The amount of chlorhexidine present in the composition may be from 5% to 95% by weight of the composition, more preferably from 10% to 80% by weight based on the weight of the composition, still more preferably on the composition. The weight is 15% to 75%. The fluazioxasulfone may be from 0.01% to 50% by weight, preferably from 0.05% to 20% by weight, still more preferably from 0.1% to 10% by weight, still more preferably still An amount of 0.1% to 5% by weight is present in the composition. In some embodiments of the invention, the composition comprises from 5% to 95% by weight of (A) chlorhexidine and from 0.01% to 50% by weight of (B) flurazepam. Preferably, the composition comprises from 10% to 75% by weight of (A) chlorhexidine and from 0.1% to 10% by weight of (B) flurazepam. More preferably, the composition comprises from 20% to 55% by weight of (A) chlorhexidine and from 0.1% to 5% by weight of (B) flurazepam.

In general, the rate of application of the active ingredient chlorhexidine and flufensulfuron depends on factors such as weed type, crop plant type, soil type, season, climate, soil ecology and various other factors. The rate of application of a composition for a given set of conditions can be readily determined by routine experimentation.

In general, the compositions and methods of the present invention may range from about 0.05 kg/ha (kg/ha) to about 2 kg per gram of the active ingredient (A) and the total amount of (B) fluridine. The application rate of hectare is applied. Preferably, the application rate is from about 0.1 kg/ha to about 1.5 kg/ha of the total amount of active ingredient. Extinction can range from 10 g/ha to 1500 g/ha, more preferably from 100 g/ha to 1000 g/ha, still more preferably from 200 The ratio is applied in a ratio of grams per hectare to 600 grams per hectare. The flufensulfuron can be used in a ratio of from 1 g/ha to 500 g/ha, preferably from 1 g/ha to 100 g/ha, more preferably from 1 g/ha to 50 g/ha. To apply. In some embodiments of the invention, the application rate of the active ingredient is from 10 g/ha to 1500 g/ha (A) chlorhexidine and from 1 g/ha to 500 g/ha (B) fluaziromime. Sulfur. Preferably, the application rate of the active ingredient is from 100 g/ha to 1000 g/ha of (A) chlorhexidine and 1 gram/ha to 100 g/ha of (B) flurazepam. More preferably, the active ingredient is applied at a rate of from 200 g/ha to 600 g/ha of (A) chlorhexidine and from 1 g/ha to 40 g/ha of (B) flurazepam.

As described above, in the present invention, chlorhexidine and flufensulfuron may be applied to plants and/or their loci separately or in combination of a part of a two-part herbicide system (for example, a composition of the present invention). . When administered separately, both chlorhexidine and flufensulfuron can be administered simultaneously and/or sequentially.

The compositions of the invention may be formulated in a conventional manner, for example by mixing chlorhexidine and flufensulfuron with suitable adjuvants. Suitable adjuvants will depend on factors such as the type of formulation and the end use. Suitable adjuvants are commercially available and are known to those skilled in the art.

In particular, the composition may further comprise one or more auxiliary agents selected from the group consisting of fillers, carriers, solvents, surfactants, stabilizers, antifoaming agents, antifreeze agents, preservatives, antioxidants, colorants, Thickeners, solid binders, fillers, wetting agents, dispersants, lubricants, anti-caking agents and diluents. Such adjuvants are known in the art and are commercially available. Their use in the formulation of the compositions of the present invention will be apparent to those of ordinary skill in the art.

Suitable formulations for the administration of the combination of chlorhexidine and flufensulfuron and the compositions of the invention include solution (SL), emulsion (EC), water-based emulsion (EW), microemulsion (ME), water Suspension (SC), oil-based suspension (OD), flowable suspension (FS), water-dispersible granules (WG), water-soluble granules (SG), wettable powder (WP), water-soluble Powder (SP), granules (GR), capsule granules (CG), fine granules (FG), large granules (GG), concentrated suspoemulsion (SE), capsule suspension (CS) and microgranules (MG ).

Preferred formulation types for use in the compositions of the present invention are aqueous suspensions (SC), water Dispersible granules (WG), water soluble granules (SG) and wettable powders (WP).

The composition may comprise one or more inert fillers. Such inert fillers are known in the art and are commercially available. Suitable fillers include, for example, natural ground minerals such as kaolin, alumina, talc, chalk, quartz, attapulgite, montmorillonite, and diatomaceous earth; or synthetic ground minerals such as highly dispersed tannins, alumina , citrate, and calcium phosphate and calcium hydrogen phosphate. Suitable inert fillers for the granules include, for example, comminuted and classified natural minerals (such as calcite, marble, pumice, sepiolite, and dolomite), or synthetic particles of inorganic and organic abrasive materials, together with particles of organic materials (eg, Sawdust, coconut shells, corn cobs, and tobacco stems).

The composition may comprise one or more surfactants which are preferably nonionic, cationic and/or anionic in nature and which have good emulsifying, dispersing and moisturizing properties. A wet-acting surfactant mixture, depending on the active compound/each compound to be formulated. Suitable surfactants are known in the art and are commercially available.

Suitable anionic surfactants can be both so-called water-soluble soaps and water-soluble synthetic surface-active compounds. Soaps which may be used include substituted ammonium salts or unsubstituted ammonium salts of alkali metals, alkaline earth metals or higher fatty acids (C ₁₀ -C ₂₂ ), for example, sodium or potassium salts of oleic acid or stearic acid, or A sodium or potassium salt of a mixture of natural fatty acids.

The surfactant system can comprise an ionic or nonionic emulsifier, dispersant or wetting agent. Examples of such surfactants include polyacrylates, lignosulfonates, besylate or naphthalenesulfonates, ethylene oxide with fatty alcohols or polycondensates with fatty acids or with fatty amines, substituted phenols (especially It is an alkylphenol), a sulfosuccinate salt, a taurine derivative (especially an alkyl taurate) and a phosphate ester of a polyethoxylated phenol or alcohol.

The presence of at least one surfactant is generally required when the active compound and/or inert carrier and/or adjuvant/adjuvant are not soluble in water and are used in the carrier water of the final application of the composition.

The composition further comprises one or more polymeric stabilizers as appropriate. Suitable polymeric stabilizers that can be used in the present invention include, but are not limited to, polypropylene, polyisobutylene, polyisoprene, copolymers of monoolefins and diolefins, polyacrylates, polystyrene, polyacetic acid Vinyl ester, polyurethane or polyamine. Suitable stabilizers are known in the art and are commercially available.

It is generally believed that the surfactants and polymeric stabilizers described above impart stability to the composition, thereby allowing the composition to be formulated, stored, transported, and applied.

Suitable antifoaming agents include all materials which can normally be used for this purpose in agrochemical compositions. Suitable antifoams are known in the art and are commercially available. A particularly preferred antifoaming agent is a mixture of polydimethyloxane and perfluoroalkylphosphoric acid, such as an anthrone defoamer commercially available from GE or Compton.

Suitable solvents for inclusion in the composition may be selected from all customary organic solvents which completely dissolve the active compounds chlorpyrifos and flufensulfuron. In addition, suitable organic solvents for chlorhexidine and flurazine are known in the art. The solvents mentioned below may be considered to be preferred: N-methylpyrrolidone, N-octylpyrrolidone, cyclohexyl-1-pyrrolidone; or paraffin, isoparaffin, cycloparaffin and mixtures of aromatic hydrocarbons, e.g. SOLVESSO ^TM 200. Suitable solvents are commercially available.

Suitable preservatives for use in the compositions of the present invention include all materials which are normally used for this purpose in this type of agrochemical composition, and are also well known in the art. Suitable examples which may be mentioned include the commercially available preservatives PREVENTOL® (from Bayer AG) and PROXEL® (Bayer).

Suitable antioxidants for use in the compositions of the present invention are all materials which are normally used in agrochemical compositions for this purpose as is known in the art. Preferred is butylated hydroxytoluene.

Suitable thickeners for use in the composition include all materials which are normally used in agrochemical compositions for this purpose, such as xanthan gum, PVOH, cellulose and its derivatives, clay hydrated niobate, tantalum Magnesium aluminum silicate or a mixture thereof. Again, such thickeners are known in the art and are commercially available.

The composition may further comprise one or more solid attachment agents. Such adhesives are known in the art and are commercially available. They include organic binders including tackifiers such as cellulose or substituted cellulose, natural and synthetic polymers in the form of powders, granules, or latex, and inorganic binders such as gypsum and lanthanum. Stone or cement.

In the methods and uses of the present invention, the combination of the active ingredient chlorhexidine and flufensulfuron can be applied to the plants by any suitable method, for example, applied to the leaves of the plants, and/or where they are controlled, Such as the surrounding soil. "Location" means the location where the plant is grown, the location of the plant's propagation material, or the location of the plant propagation material where the plant will be planted.

As indicated above, the present invention also relates to the use of a combination of chlorhexidine and flufensulfuron in, for example, the above compositions or formulations for controlling or altering undesirable plant growth in a crop. The combination of chlorhexidine and flurazine is suitable for treating a range of crops including cereals such as wheat, barley, rye, oats, corn, rice, sorghum, triticale and related crops; beets, such as sugar beets and Forage beet; fruit, such as pear fruit, stone fruit, and soft fruit (such as apples, grapes, pears, plums, peaches, almonds, cherries, and berries (such as strawberries, raspberries, and blackberries); legumes, such as beans, lentils) , peas, soybeans and peanuts; oil plants, such as canola, mustard and sunflower; cucurbitaceae, such as zucchini, cucumber and melon; fiber plants such as cotton, flax, hemp and jute; citrus fruits such as orange, lemon, grapefruit And citrus; vegetables such as spinach, lettuce, asparagus, cabbage, carrots, onions, tomatoes, potatoes and red peppers; ornamental plants such as flowers, shrubs, broadleaf and evergreens (such as conifers) and sugar cane.

In a preferred embodiment, the method or composition of the invention is used to control undesirable plant growth in cereals, legumes, fiber plants and vegetables, preferably wheat, barley, rye, oats, More preferably corn, rice, sorghum, triticale, beans, lentils, peas, soybeans and peanuts, cotton, flax, hemp, jute, spinach, lettuce, asparagus, cabbage, carrots, onions, tomatoes, potatoes and red peppers. Undesirable plant growth in wheat, barley, corn, rice, soybeans, cotton, tomatoes and potatoes.

Suitable crops that can be treated include those that are resistant to chlorpyrifos and flufensulfuron. Tolerance may be natural tolerance produced by selective breeding, or may be artificially introduced by genetic modification of crop plants. In this aspect, 'tolerance' means less sensitive to damage caused by one or more specific herbicides, in this case chlorhexidine and flufensulfuron.

The active ingredients employed in the practice of the present invention can be administered in various concentrations in a variety of ways known to those skilled in the art. The methods and compositions of the present invention can be used to control undesirable plant growth by applying active ingredients to plants to be controlled and/or their locus prior to, prior to, and/or after germination.

The active ingredient chlorfenapyr and flufensulfuron can be applied to undesired plants and crops to be protected and/or their locus by conventional methods, including coating, spraying, spraying, dipping, Soak, inject, irrigate, etc.

The method of the present invention may employ other pesticides than the combination of chlorhexidine and flufensulfuron. For example, the compositions of the present invention may contain or be mixed with other pesticides (e.g., fungicides, insecticides, and nematicides), growth factor enhancers, and fertilizers to enhance the therapeutic activity of the present invention or to broaden its range of activity. Similarly, the methods of the invention can be used in combination with one or more of the foregoing active ingredients to again achieve enhanced potency or a broader range of activity.

The embodiments of the present invention are now described by way of the following examples for the purpose of illustration only.

Percentages are by weight unless otherwise specified.

Instance

Formulation example

Water-dispersible granules (WG) were prepared by mixing and grinding the active ingredients and auxiliaries under compressed air (0.5% SUPRALATE® (sodium lauryl sulfate, Witco Inc., Greene) Greenwich), 5% REAX® 88B (sodium lignosulfonate, Westvaco Corp), potassium carbonate (balanced to 100%), then wetted, extruded and dried to obtain Water-dispersible granules.

For example, a water dispersible granule (WG) formulation is prepared from the following components: 100%

By mixing finely ground active ingredients with auxiliaries (10% propylene glycol, 5% tristyryl phenol ethoxylate, 1% sodium lignosulfonate, 1% carboxymethyl cellulose, 1% eucalyptus oil (75%) An aqueous suspension (SC) was prepared in the form of a water emulsion, 0.1% xanthan gum, 0.1% NIPACIDE BIT 20, and water (equal to 1 L).

For example, an aqueous suspension (SC) formulation is prepared from the following components:

Water-soluble granules (SG) were prepared by mixing and grinding the active ingredients and auxiliaries under compressed air (0.5% SUPRALATE® (sodium lauryl sulfate, Viterco, Greenwich), 5% REAX®88B (sodium lignosulfonate, Visvik), 2% sodium bicarbonate (NaHCO ₃ ), potassium sulphate (balanced to 100%), then wetted, extruded and dried to obtain water soluble granules Agent.

For example, a water soluble granule (SG) formulation is prepared from the following components:

A wettable powder (WP) formulation was prepared by mixing and grinding the active ingredients and auxiliaries (5% DISPERSOGEN® 1494; 8% SIPERNAT® 622S, kaolin (balanced to 100 g) under compressed air.

For example, a wettable powder (WP) formulation is prepared from the following components:

A series of Formulation Examples 1 to 9 were prepared according to the methods described above. The formulation type and active ingredient content are summarized in Table A below.

Examples 1 and 2 are comparative examples.

Biological example

When the activity of the combination of the two active compounds is greater than the sum of the activities of the two active compounds administered alone, a synergistic effect occurs in the combination of the two active compounds.

The expected activity of a given combination of two active compounds can be calculated by the so-called "Colby formula" (see SR Colby, "Calculating synergistic and antagonistic responses of herbicide combinations (Calculating) Synergistic and Antagonistic Responses of Herbicide Combinations), Weeds 1967, 15, 20-22): By: E=A+B-(A×B/100)

Wherein: A = percentage of activity of compound A when active compound A is used at an application rate of m g/ha; B = percentage of activity of compound B when active compound B is used at an application rate of n g/ha; The percentage of activity estimated when Compounds A and B were used together at an application rate of m grams per hectare and n grams per hectare.

If the actual activity observed for the combination of compounds A and B is greater than the activity calculated using the above formula, then the combined activity is superadditive, ie there is a synergistic effect.

Biological example 1

Wheat, barley and corn plants are planted in randomized blocks of the field. Different types of weeds exist and their relative densities in each block are identified and are listed in Table 1 below.

The compositions according to Examples 1 to 9 were applied by spraying after 50 days of planting. After spraying, each block was held for about 2 weeks.

After two weeks of application, each block was examined to determine the effectiveness of each formulation in controlling weed growth. The results are set forth in Table 2 below.

The efficacy of this treatment in controlling weed growth is expressed as the percentage of weeds killed after treatment.

As can be seen from the results set forth in Table 2, the present invention comprises chlorhexidine and flufensulfuron-methyl compared to the effect of chlorhexidine alone or fluridine or the combination of the two active ingredients. The combined formulation exhibits a significantly increased effect in controlling target weeds. This increased effect clearly shows the synergy between the two active ingredients.

Biological example 2

Soybeans and cotton plants are sown in randomized blocks of the field. Different types of weeds exist and their relative densities in each block are identified and are listed in Table 3 below.

The compositions according to Examples 1 to 9 were applied by spraying after 50 days of planting. After spraying, each block was held for about 2 weeks.

After two weeks of application, each block was examined to determine the effectiveness of each formulation in controlling weed growth. The results are set forth in Table 4 below.

The efficacy of this treatment in controlling weed growth is expressed as the percentage of weeds killed after treatment.

As can be seen from the results set forth in Table 4 above, the inclusion of chlorhexidine and fluridine in the present invention is compared with the effect of chlorhexidine alone and fluridine or the combination of the two active ingredients. The combined formulation of the keel exhibited a significantly increased effect in controlling the target weeds. This increased effect clearly indicates a synergy between the two active ingredients.

Biological example 3

Sowing tomato and potato plants in the randomized blocks of the field. Different types of weeds exist and their relative densities in each block are identified and are listed in Table 5 below.

The compositions according to Examples 1 to 9 were applied by spraying after 50 days of planting. After spraying, each block was held for about 2 weeks.

After two weeks of application, each block was examined to determine the effectiveness of each formulation in controlling weed growth. The results are set forth in Table 6 below.

The efficacy of this treatment in controlling weed growth is expressed as the percentage of weeds killed after treatment.

It can be seen from the results set forth in Table 6 that the present invention comprises chlorhexidine and flufensulfuron-methyl compared to the effect of chlorhexidine alone or fluridine or the combination of the two active ingredients. The combined formulation exhibits a significantly increased effect in controlling target weeds. This increased effect clearly indicates a synergy between the two active ingredients.

Biological example 4

Rice is sown in a randomized block of the field. Different types of weeds exist and their relative densities in each block are identified and are listed in Table 7 below.

The compositions according to Examples 1 to 9 were applied by spraying after 50 days of planting. After spraying, each block was held for about 2 weeks.

After two weeks of application, each block was examined to determine the effectiveness of each formulation in controlling weed growth. The results are set forth in Table 8 below.

The efficacy of this treatment in controlling weed growth is expressed as the percentage of weeds killed after treatment.

It can be seen from the results set forth in Table 8 that the present invention comprises chlorhexidine and flufensulfuron-methyl compared to the effect of chlorhexidine alone or fluridine or the combination of the two active ingredients. The combined formulation exhibits a significantly increased effect in controlling target weeds. This increased effect clearly indicates a synergy between the two active ingredients.

Claims (40)

A composition comprising a herbicidally effective amount of (A) chlorhexidine and (B) flurazepam. The composition of claim 1, wherein the weight ratio of chlorhexidine to flufensulfuron is at most 400:1. The composition of claim 2, wherein the weight ratio of chlorhexidine to flufensulfuron is at most 200:1. The composition of claim 3, wherein the weight ratio of chlorhexidine to flufensulfuron is from 200:1 to 1:1. The composition of claim 4, wherein the weight ratio of chlorhexidine to flufensulfuron is in the range of from 70:1 to about 10:1. A composition according to any of the preceding claims, wherein the total amount of chlorhexidine and flurazine is from 5% to 99% by weight of the composition. A composition according to any of the preceding claims, wherein the chlorhexidine is present in an amount from 5% to 95% by weight. A composition according to any of the preceding claims, wherein the flufensulfuron is present in an amount from 0.01% to 50% by weight. The composition of claim 8, wherein the composition comprises from 10% to 75% by weight of chlorhexidine and from 0.1% to 10% by weight of flufensulfuron. A composition according to any of the preceding claims, further comprising one or more auxiliaries selected from the group consisting of fillers, carriers, solvents, surfactants, stabilizers, antifoaming agents, antifreeze agents Preservatives, antioxidants, colorants, thickeners, solid binders, fillers, wetting agents, dispersants, lubricants, anti-caking agents and diluents. A composition according to any of the preceding claims, which is formulated as a solution (SL), an emulsion (EC), a water-based emulsion (EW), a microemulsion (ME), an aqueous suspension (SC), an oil Base water suspension (OD), flowable suspension (FS), moisture Granular granules (WG), water-soluble granules (SG), wettable powders (WP), water-soluble powders (SP), granules (GR), capsule granules (CG), fine granules (FG) , large granules (GG), concentrated suspoemulsion (SE), capsule suspension (CS) or microgranules (MG). A herbicidal composition substantially as hereinbefore described. A method of controlling undesirable plant growth comprising applying a herbicidally effective amount of (A) chlorhexidine and (B) flurazepam to a plant or locus thereof. The method of claim 13, wherein the undesired plant growth is controlled in a crop comprising cereals, legumes, fiber plants, and vegetables. The method of claim 14, wherein the controlled plant is grown as one or more of broadleaf, grass, and sedge. The method of any one of claims 13 to 15, wherein the controlled plant is grown as one or more of the following: a genus; a genus; a genus of genus; a genus; Mandala; genus of genus; genus of genus; genus; genus; genus of genus; wild sesame; genus of genus; genus of white genus; genus Solanum; genus of genus; genus of genus; The method of claim 16, wherein the controlled plant grows into one or more of the following: a genus of genus, a perennial, a Brassica napus, amaranth, a mandala, a rosegrass, Short Ying Ma Tang, Bald Donkey, Valerian, Goosegrass, Geranium, Baogai, Xiaoye Sesame, Thousands of Gold, Wild European White Mustard, Solanum nigrum, Stupid, Eyelash Po Na, Penn Xing Er. The method of any one of claims 13 to 17, wherein the total amount of the active ingredient chlorhexidine and flufensulfuron is from 0.05 kg/ha (kg/ha) to 2 g/ha. Application rate. The method of claim 18, wherein the total amount of the active ingredient chlorhexidine and flufensulfuron is applied at an application rate of from 0.1 g/ha to 1.5 g/ha. The method of any one of claims 13 to 19, wherein Must be applied at an application rate from 10 g/ha to 1500 g/ha. The method of claim 20, wherein the chlorhexidine is applied at an application rate of from 100 g/ha to 1000 g/ha. The method of any one of claims 13 to 19, wherein the flufensulfuron is applied at an application rate of from 1 g/ha to 500 g/ha. The method of claim 22, wherein the flufensulfuron is applied at an application rate of from 1 g/ha to 100 g/ha. The method of any one of claims 13 to 23, wherein the component (A) and the component (B) are applied before, before, and/or after germination. The method of any one of claims 13 to 24, wherein the chlorhexidine and the flufensulfuron are simultaneously applied to the locus. The method of claim 25, wherein the composition of any one of claims 1 to 12 is used. The method of any one of claims 13 to 24, wherein the chlorhexidine and the flufensulfuron are successively applied to the locus. The method of any one of claims 13 to 27, wherein the weight ratio of chlorhexidine to flufensulfuron is up to 400:1. The method of claim 28, wherein the weight ratio of chlorhexidine to flufensulfuron is at most 200:1. The method of any one of claims 13 to 29, wherein the weight ratio of chlorhexidine to flufensulfuron is from 200:1 to 1:1. The method of claim 30, wherein the weight ratio of chlorhexidine to flufensulfuron is in the range of from 70:1 to 10:1. The method according to any one of claims 13 to 31, wherein the application rate of the total amount of the active ingredient chlorhexidine and flufensulfuron applied is from 0.05 g/ha (kg/ha) to 2 kg / ha. The method of claim 32, wherein the application rate of the total active ingredient of chlorfenapyr and flufensulfuron is from 0.1 kg/ha (kg/ha kg/ha) to 1.5 kg/ Hectare. The method of any one of claims 13 to 33, wherein the chlorhexidine is applied at an application rate of from 10 g/ha to 1500 g/ha. The method of claim 34, wherein the chlorhexidine is applied at an application rate of from 100 g/ha to 1000 g/ha. The method of any one of claims 13 to 35, wherein the flufensulfuron is applied at an application rate of from 1 g/ha to 500 g/ha. The method of claim 36, wherein the flufensulfuron is applied at an application rate of from 1 g/ha to 100 g/ha. A method for controlling undesired plant growth substantially as described in the above. A use of a combination of chlorhexidine and flufensulfuron in controlling the growth of plants in a locus. The use of a combination of chlorhexidine and flufensulfuron substantially as described in the above.