TWI723032B - 雙醋瑞因或瑞因外用製劑及其用途 - Google Patents

雙醋瑞因或瑞因外用製劑及其用途 Download PDF

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TWI723032B
TWI723032B TW105120973A TW105120973A TWI723032B TW I723032 B TWI723032 B TW I723032B TW 105120973 A TW105120973 A TW 105120973A TW 105120973 A TW105120973 A TW 105120973A TW I723032 B TWI723032 B TW I723032B
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composition
item
patent application
scope
diacerein
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TW105120973A
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TW201717932A (zh
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陳志光
李靜宜
盧威書
步朗 周
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安成生物科技股份有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
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    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW105120973A 2015-07-01 2016-07-01 雙醋瑞因或瑞因外用製劑及其用途 TWI723032B (zh)

Applications Claiming Priority (2)

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US201562187743P 2015-07-01 2015-07-01
US62/187,743 2015-07-01

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TW201717932A TW201717932A (zh) 2017-06-01
TWI723032B true TWI723032B (zh) 2021-04-01

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US (1) US9744131B2 (enExample)
EP (1) EP3316879A4 (enExample)
JP (3) JP7577428B2 (enExample)
KR (1) KR102702557B1 (enExample)
CN (2) CN107921013A (enExample)
AU (2) AU2016287636B2 (enExample)
CA (1) CA2990948C (enExample)
HK (1) HK1249057A1 (enExample)
IL (1) IL256585B (enExample)
MX (1) MX373702B (enExample)
TW (1) TWI723032B (enExample)
WO (1) WO2017004319A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6887987B2 (ja) * 2015-08-17 2021-06-16 ティダブリューアイ・バイオテクノロジー・インコーポレイテッドＴＷＩ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ， Ｉｎｃ． Ａｓｃの発現、ｎｌｒｐ３の発現、及び／又はｎｌｒｐ３インフラマソーム複合体の形成を阻害するためのジアセレイン又はそのアナログ
TWI794200B (zh) * 2017-01-19 2023-03-01 安成生物科技股份有限公司 預防或治療免疫發炎性皮膚疾病的方法及醫藥組合物
CN106692037B (zh) * 2017-01-24 2020-02-18 中南大学湘雅医院 大黄酸超分子水凝胶及其制备方法和应用
CN107823126B (zh) * 2017-12-04 2020-03-24 广东药科大学 双醋瑞因注射型温敏凝胶及其制备方法
CN111265508B (zh) * 2018-12-05 2022-03-25 中检科医药科技(北京)集团有限公司 双醋瑞因在制备抗病毒药物及治疗病毒感染中的用途
CN109758421A (zh) * 2019-03-27 2019-05-17 毕波 一种蓝氧抗菌灭毒软膏及其制备方法
IN201941031481A (enExample) 2019-08-03 2021-02-05
CN110585120B (zh) * 2019-10-08 2020-11-27 中南大学 一种可注射双醋瑞因水凝胶及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6124358A (en) * 1996-12-23 2000-09-26 Mazal Pharmaceutique (Sarl) Pharmaceutical composition containing rhein or diacerhein with improved bioavailability

Family Cites Families (10)

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Publication number Priority date Publication date Assignee Title
JP4018764B2 (ja) * 1996-10-18 2007-12-05 正規 小菅 津液改善用皮膚外用剤
US7704522B2 (en) 2004-09-08 2010-04-27 Clyde Morgan Topical medicament
US20100285114A1 (en) 2007-09-27 2010-11-11 Rahul Dabre Pharmaceutical compositions of rhein or diacerein
WO2009047562A1 (en) * 2007-10-08 2009-04-16 Serentis Limited Methods and compositions for the treatment of pruritus
WO2009133430A1 (en) * 2008-04-30 2009-11-05 Wockhardt Research Centre Topical compositions of rhein or diacerein
TWI473610B (zh) * 2008-10-28 2015-02-21 Twi Biotechnology Inc 包含雙醋瑞因（ｄｉａｃｅｒｅｉｎ）之醫藥組合物
FR2949044B1 (fr) * 2009-08-12 2021-05-07 Expanscience Lab Composition comprenant une fraction d'insaponifiable
KR101567925B1 (ko) 2010-04-08 2015-11-10 티더블유아이 바이오테크놀로지 인코포레이티드 당뇨병 보조치료요법으로서 디아세레인을 사용하는 방법
EP2598536A1 (en) * 2010-07-29 2013-06-05 Université de Genève Process for the esterification of hyaluronic acid with hydrophobic organic compounds
US8865689B2 (en) 2011-03-11 2014-10-21 Twi Biotechnology, Inc. Methods and compositions for treating hyperuricemia and metabolic disorders associated with hyperuricemia

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6124358A (en) * 1996-12-23 2000-09-26 Mazal Pharmaceutique (Sarl) Pharmaceutical composition containing rhein or diacerhein with improved bioavailability

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AU2021229177B2 (en) 2023-11-23
AU2016287636B2 (en) 2021-09-16
US9744131B2 (en) 2017-08-29
IL256585B (en) 2021-05-31
US20170000732A1 (en) 2017-01-05
JP7578651B2 (ja) 2024-11-06
EP3316879A4 (en) 2019-01-23
IL256585A (en) 2018-02-28
HK1249057A1 (zh) 2018-10-26
EP3316879A1 (en) 2018-05-09
KR102702557B1 (ko) 2024-09-03
CN107921013A (zh) 2018-04-17
JP7893842B2 (ja) 2026-07-22
AU2016287636A1 (en) 2018-02-08
MX373702B (es) 2020-05-07
AU2021229177A1 (en) 2021-10-07
MX2018000264A (es) 2018-05-23
KR20180023965A (ko) 2018-03-07
JP2024164022A (ja) 2024-11-26
JP2022169600A (ja) 2022-11-09
JP2018522875A (ja) 2018-08-16
CN117482078A (zh) 2024-02-02
WO2017004319A1 (en) 2017-01-05
TW201717932A (zh) 2017-06-01
CA2990948C (en) 2024-09-10
JP7577428B2 (ja) 2024-11-05
CA2990948A1 (en) 2017-01-05

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