TWI699703B - Detection system with recognition label compensation function - Google Patents

Abstract

A detection system with identification label compensation function includes an in vitro detector for inserting a quick screening test paper and shooting images, and then transmitting to an electronic device for comparison and analysis, wherein the identification label set on the quick screening test paper is at least It has a first reading message, including the type of the quick screening test paper, the algorithm corresponding to the basic data of the test item, and; a second reading message, including the standard test parameters in a fixed environment, for the quick screening test paper The signal presented by the control line is measured and corrected. The key point is to make the measured value of the quick screening test paper comparable with the measured value set under fixed environmental conditions, and use the algorithm to compensate the measured value of the test group according to the difference, so that the tested item will produce an accurate The test report will not be affected by different external environments.

Description

Detection system with recognition label compensation function

The present invention relates to the technical field of in-vitro detection systems, and particularly refers to a detection system with an identification tag compensation function.

With the continuous advancement of detection technology, there are many quick screening test devices or quick screening test papers that can know the results instantly, such as pregnancy test sticks or flu quick screening test papers. Although they claim to be simple and easy to use, the current quick screening The test paper can only tell the testee a negative or positive reaction based on the result. It cannot reflect the accurate grading test result and cannot provide more information about the testee. Especially during the test, if the test substance contains a low concentration of the tested antigen/antibody, the result of the quick screening test paper after the test is not easy to be recognized by the naked eye, resulting in wrong judgment and cognition, and providing the testee with wrong information , So it is easy to cause physical and mental panic of the subject and family members, or cause unnecessary medical waste.

Although, at present, it can be overcome by capturing the image of the quick screening test paper after the test, and then analyzing it through a specific device. For example, there are imaging equipment dedicated to testing in the hospital, but this special equipment is huge and expensive, and it can be easily purchased or obtained by non-ordinary people, and the testee needs to spend a lot of time in the hospital during testing; in addition, there are some on the market The portable electronic device can capture the displayed image of the quick screening test paper after the test, and then send it to a computing server or a compatible device such as a smart phone or computer to obtain the test result; but its disadvantage is that When using a portable electronic device, it’s troublesome to set up a stand for shooting, and it’s in an open space for shooting. The shot images are likely to vary depending on the environment, which may lead to errors in interpretation, plus different styles Portable electronic devices have different pixels, focusing distances, or sensitivity, and the captured images will also have gaps, which will easily lead to errors in interpretation and cause many inconveniences.

In particular, the existing quick screening test strips are disposable disposable products. Each batch of built-in test strips is of different quality, which is easily affected by differences in materials and manufacturing processes, resulting in differences between batches, and it is easy to cause differences in the interpretation of results. accuracy. Although the existing quick screening test papers all have a sample area, an observation area, and an identification label, the identification label of the conventional quick screening test paper is usually only used to provide the name, serial number, and manufacturing date of the related product. Information is only, in fact, it cannot be used to effectively solve the problem of different test results caused by differences in test strip batch production.

It cannot be used to solve the problem. The traditional quick screening test paper is because the quick screening test reagent uses the immunoassay test technology and the principle of chromatography. After the sample is dropped into the sample area, the sample is diffused to the test group and the control by chromatography In the control group, the control group is the Control Line, and the test group is the Test Line. The reaction of the Control Line is the binding reaction of the antibody and the antigen as with the Test Line, and it will also be affected by the surrounding environment. Among them, when operating under different environmental conditions (for example: temperature), the control line reaction of the control group will be affected, which obviously causes the disadvantage of different test results and loss of accuracy.

In order to solve the above-mentioned problems, a detection system with identification tag compensation function that can be carried around and knows the reaction result and the degree of reaction in real time is developed according to the present invention.

The object of the present invention is to provide a detection system with recognition label compensation function, including: an in vitro detector, a quick screening test paper, and an electronic device, wherein the in vitro detector is a closed environment with a photography function, which is very useful for peripherals There is a specimen insertion port for inserting the quick screening test paper and shooting images, and then transmitting to the electronic device for comparison and analysis. The feature is that the quick screening test paper has a sample area, an observation area, and an identification label. The observation area has at least a test group and a control group, and the corresponding content of the identification tag has at least a first read message and a second read message, wherein the first read message includes at least the quick screen The algorithm corresponding to the type of the test paper and the basic data of the test item; the second read message includes at least the standard test parameters of the fast screening test paper in a fixed environment for the control line of the sample area on the fast screening test paper (Control Line) The presented signal is measured and calibrated; thereby, when the present invention is applied, the type of test paper and the basic data of the test item conveyed in the first read message are used to allow the analysis software in the electronic device to generate a parameter package and a corresponding Determine the data, and then compare the determination data with a corresponding algorithm and a data parameter downloaded from the cloud to generate a measurement value of the test group; in addition, the second read message can be read from the cloud The downloaded algorithm compares one of the measurement values of the aforementioned control group with the measurement value set by the system under fixed environmental conditions, and generates a compensatory correction for the measurement value of the test group based on the difference. ; Thus, the physiological response of the subject can be tested to produce an accurate test report, will not be affected by different external environments, in order to achieve the function of early detection, early prevention and planning.

In order to achieve the above-mentioned purpose, the technical means of the present invention will set up a comparison database in the cloud. The comparison database has content corresponding to the first read message of the identification tag and a second read message. A variety of different levels of physiological response detection image results, and the detection image results generate the data parameters through the cloud computing. When the user opens the analysis software in the electronic device, the analysis software will automatically download the data parameters and save them In the analysis software; when the detection is completed, the electronic device receives the display image transmitted from the in vitro detector, and through the analysis software, a parameter package with physiological response parameters, display images, and a current detection The result of the judgment data, the analysis software will further send the parameter package to the cloud for data storage and collection. At the same time, the judgment data and the data parameter will be compared with the degree of response according to the detection category, and further generate The test report of the degree of physiological reaction.

10: In vitro detector

101: Specimen insertion port

11: Control Panel

111: Power button

112: Image capture button

13: view panel

131: Power indicator

132: Wireless connection indicator

133: Specimen display light

134: Transmission indicator

14: USB connection slot

15: Specimen box

151: Sensor

16: shooting image processor

17: Transmission interface control processor

18: Power supply unit

20: Quick screening test paper

21: Sample area

22: Observation area

221: Test Group

222: control group

23: Identify tags

231: First read message

232: Second read message

30: Electronic device

31: Analysis software

40: Cloud

Figure 1 is a configuration diagram of the system of the present invention.

Figure 2 is a plan view of the quick screening test paper of the present invention.

Figure 3 is a flowchart of the test application of the present invention.

Figure 4 is the reaction diagram of the quick screening test paper.

Figure 5 is an external view of the in vitro detector of the present invention.

Figure 6 is the internal structure diagram of the in vitro detector of the present invention.

In order to facilitate your reviewer to have a further understanding and understanding of the technical means and operation process of the present invention, an example is given in conjunction with the diagram, and the detailed description is as follows.

Please refer to Figures 1 and 2, the present invention relates to a detection system with recognition label compensation function, comprising an in vitro detector 10, a quick screening test paper 20, and an electronic device 30, wherein the in vitro detector 10 is an A closed environment with photography function is provided with a specimen insertion port 101 for the quick screening test paper 20 to insert and shoot images, which are then transmitted to the electronic device 30 for comparison and analysis. The feature is that the quick screening test paper 20 has A sample area 21, an observation area 22, and an identification label 23. The observation area 22 has at least a test group 221 and a control group 222. The identification label 23 can be a one-dimensional bar code or a two-dimensional bar code. It is not limited to this, and the corresponding content of the identification tag 23 has at least a first read message 231 and a second read message 232, wherein the first read message 231 includes at least the quick screening test paper 20 The type of test paper and the algorithm corresponding to the basic data of the test item; the second read message 232 includes at least the standard test parameters of the fast screening test paper 20 in a fixed environment, and is provided for the control line of the sample area 21 on the fast screening test paper 20 The signal presented by the Control Line is measured and corrected.

With the above effective design, the present invention has the following advantages when testing and applying:

First, the first read message 231 of the identification tag 23 can be read by the in vitro detector 10, and the mobile phone APP connected via Bluetooth is downloaded to the cloud 40 and the algorithm represented by the first read message 231 is applied. , Interpretation of fast screening test paper 20.

Application note: Use the in vitro detector 10 to capture and scan the images of the control group 222 and the identification tag 23 on a quick screening test paper 20 to be tested, connect an electronic device 30 through a wired or wireless way, and capture the image to the electronic device 30 in. When the in vitro detector 10 initially obtains the first reading message 231 by reading the identification label 23 on the quick screening test paper 20, it can clearly know the type of test paper and the basic data of the test item, and it will read and download the relevant identification from the cloud 40 The algorithm corresponding to the first read message 231 of the tag 23 is sent to an electronic in vitro detector 10 to perform the comparison result analysis and storage function of the test group 221 and the control group 222.

Second, the second read message 232 of the identification tag 23 can be used as the signal presented by the Control Line of the sample area 21 on the quick screening test paper 20 for measurement and calibration.

Application note: When the quick screening test paper 20 reagent is used, after dropping the sample in the sample area 21, the sample is diffused to the test group 221 and the control group 222 by chromatography. When operating under different environmental conditions, such as The temperature difference between tropical countries and frigid countries affects the control line response of the control group 222. At this time, it can be used to compare with the control line response signal of the second reading message 232 that has selected the standard test parameters of the fixed environmental conditions. In order to calculate the difference ratio caused by the measurement effects under different environments, the analysis results of the Test Line of the test group 221 are compensated for correction to obtain more accurate analysis values.

Third, the corresponding content of the second read message 231 of the identification tag 23 can also be extended to reduce the difference between test strips.

Application note: Mainly because the results of the observation area 22 of the general quick screening test paper 20 may be affected by differences in materials and manufacturing processes, resulting in differences between batches, which will lead to differences in the system's interpretation of results, so it can be used at this time The second reading message 231 of the identification tag 23 is read to load different operation parameters, and then the result of calibration and proofreading of the observation area 22 is achieved.

Fourth, the second read message 231 of the second point identification tag 23 can also be extended to control the validity period of the test paper.

Application note: Through the identification label 23 of the quick screening test paper 20, the expiration date of the test paper can be recorded in the cloud 40, thereby limiting the use of the expired test paper, and avoiding possible misinterpretation caused by the expired test paper to confuse the user's physiological value interpretation.

As a result, as shown in Figures 1 to 4, the system can be used to determine whether the quick screening test paper 20 is still in the shelf life when the system performs the detection with the recognition label compensation function? If not, the expired electronic device 30 will not be judged. If so, it will be further judged whether the quick screening test paper 20 to be tested has a control line 222. If the Control Line of the quick screening test paper 20 does not appear, the electronic device 30 will determine Invalid response (invalid), if it is, then compare whether the control line is the same as the control line 222 Control Line under fixed environmental conditions, if not, use the parameter package to interpret the test line data of the test group 221; If so, calculate the difference ratio of the Control Line (C line) and then make a compensatory correction to the result of the Test Line (T line) to obtain a more accurate analysis value.

More specifically, the system of the present invention described above can be applied to various convenient and portable in vitro detectors 10 and different types of quick screening test papers 20, wherein the in vitro detector 10 and the electronic device 30 can be wired or wireless The electronic device 30 can be a smart phone, a tablet computer, a desktop computer, a notebook computer, and so on.

As shown in Figs. 1 and 5, the shape of the in vitro detector 10 of the present invention can be diversified, and its appearance is not limited to this, and can also be designed in other different shapes.

Taking Figure 5 as an example, one of the external detectors 10 has a control panel 11, and the control panel 11 is provided with a power button 111 and an image capture button 112. The external detector 10 has a specimen insertion port 101 and a USB connection slot 14. The specimen insertion port 101 and the USB connection slot 14 are respectively provided on different sides, and the extracorporeal detector 10 has a viewing panel 13, the viewing panel A power indicator light 131, a wireless connection indicator light 132, a specimen indicator light 133, and a transmission indicator light 134 are provided on the 13 to remind the user whether the extracorporeal detector 10 is activated and operating conditions.

As shown in FIGS. 5 and 6, the in vitro detector 10 is a closed environment with a specimen box 15, a shooting image processor 16, a transmission interface control processor 17, and a power supply unit 18. Among them, a quick screening test paper 20 after testing can be inserted into the sample box 15 from the sample insertion port 101, and when the quick screening test paper 20 after testing touches one of the ends of the sample box 15 When the sensor 151 is activated, the specimen display light 133 of the viewing panel 13 will be activated, so that the user will know that the quick screening test paper 20 after the test is correctly inserted, and can start the image capture, the captured image The processor 16 is arranged on one side of the specimen box 15 and is electrically connected to the image capturing button 112. Through the image capturing button 112, the shooting image processor 16 is controlled to capture the test in the specimen box 15 One of the subsequent quick screening test papers 20 displays an image, and transmits the displayed image to the transmission interface control processor 17. The transmission interface control processor 17 can be wireless Bluetooth transmission or wifi transmission, and can also be connected to it. The USB connection slot 14 of the sexual connection performs wired transmission, and the displayed image is directly output to the electronic device 30 for analysis by wireless or wired means, and the transmission indicator light 134 of the viewing panel 13 is activated.

Please refer to Figures 1 and 2, the electronic device 30 has an analysis software 31. When the detection is completed, the electronic device 30 receives the display image transmitted by the in vitro detector 10, and the analysis software 31 displays the image After the image is processed for de-backing, de-noising and sharpness, a parameter package and a judgment data are generated respectively, and the parameter package contains the information of the identification tag 23 The number and the image of the test group 221 are transmitted to the cloud 40 of the present invention, and the judgment data is generated by the image of the test group 221.

A comparison database corresponding to the analysis software 31 is provided in the cloud 40. The comparison database contains contents corresponding to the first read message 231 and a second read message 232 of the identification tag 23, and has The displayed images of multiple physiological response tests of different levels. Due to the different degrees of physiological response, the concentration of the components to be detected in the sample will be different, so the results of the quick screening test paper 20 presented after the test will also have different depths. When the user turns on the electronic device 30 in a wired environment, the analysis software 31 will automatically download the latest data parameters from the cloud 40, so that the detection result can still be performed when the electronic device 30 is wireless The comparison.

After the cloud 40 receives the parameter package sent from the analysis software 31, it classifies and archives the data according to the physiological response parameters contained in the parameter package and the image of the test group 221. If the provided image is new, the The control database will be updated so that the content corresponding to the first reading message 231 and the second reading message 232 of the identification tag 23 on the quick screening test paper 20 can be downloaded by the analysis software 31 to make the In the application of the invention, the analysis software in the electronic device 30 correspondingly generates a parameter package and a judgment data through the test paper type and basic data of the test item conveyed in the first read message 231, and then the judgment data is transferred to the cloud Compare a data parameter downloaded in 40 to generate a measurement value of the test group 221; in addition, the algorithm can be downloaded from the cloud 40 through the second read message 232 to compare one of the aforementioned control groups 222 The measured value is compared with the measured value set by the system under fixed environmental conditions, and the compensation correction for the measured value of the test group 221 is generated by the algorithm based on the difference. Thus, the subject’s physiological response to the tested item can produce an accurate test report. Report, will not be affected by the difference of the external environment, in order to achieve the function of early detection, early prevention and planning.

The in vitro detection system of the present invention captures the displayed image of the quick screening test paper 20 after the test through the in vitro detector 10 in a closed environment, and there is no need to worry about the difference in environment or shooting equipment that will affect the results of image capture. The user can carry the in vitro detector 10 with him for testing anytime and anywhere; and send the displayed image to the electronic device 30 for analysis of the results, which saves the user from uploading data by himself. Furthermore, the in vitro testing system The analysis software 31 in the electronic device 30 will periodically download the data parameters from the cloud 40. Therefore, the displayed image can be analyzed and compared under wired or wireless conditions, except that the physiological response is known to be negative/ In addition to positive, it can also analyze the degree of physiological reaction and provide suggestions to achieve the functions of early detection and early prevention and planning.

However, the above are only preferred embodiments of the present invention, and should not be used to limit the scope of implementation of the present invention; therefore, all simple equivalent changes and modifications made in accordance with the scope of the patent application of the present invention and the content of the description of the invention , Should still fall within the scope of the invention patent.

10: In vitro detector

101: Specimen insertion port

20: Quick screening test paper

21: Sample area

22: Observation area

23: Identify tags

231: First read message

232: Second read message

30: Electronic device

31: Analysis software

40: Cloud

Claims (8)

A detection system with identification label compensation function, including: an in vitro detector, a quick screening test paper, and an electronic device, wherein the in vitro detector has a closed environment, and is provided with a specimen box and a shooting image processor , A transmission interface control processor and a power supply unit, the sample box is provided with a sample insertion port for inserting the quick screening test paper to be tested; the quick screening test paper has a sample area, an observation area, And an identification tag, wherein the observation area has at least a test group and a control group, and the corresponding content of the identification tag has at least a first read message and a second read message, wherein the first read message , Including at least the quick-screening test paper, the type of test paper, and the algorithm corresponding to the basic data of the test item; the second read message includes at least the standard test parameters of the quick-screening test paper in a fixed environment for the sample on the quick-screening test paper The signal presented by the area control line is measured and calibrated; and the electronic device has an analysis software in it, which is used to receive from the extracorporeal detector through the imaging processor to capture the specimen box, and control the processing through the transmission interface The display image of the quick screening test paper after the test from the device to generate a parameter package and a judgment data; thereby, through the test paper type and basic data of the test item conveyed in the first read message, The judgment data is compared with a corresponding algorithm and a data parameter downloaded from the cloud to generate a measurement value of the test set; and the algorithm downloaded by the cloud through the second read message is used to compare the aforementioned A measurement value of the control group is compared with the measurement value set by the system under fixed environmental conditions. The algorithm generates a compensatory correction for the measurement value of the test group based on the difference, so that the subject’s physiological response is affected. Test items can produce an accurate test report. For example, the detection system with recognition tag compensation function described in the first item of the patent application, wherein the cloud has a built-in comparison database corresponding to the analysis software, and the comparison database is based on the first reading of the recognition tag Obtain the content corresponding to the message and a second read message, detect and display images with a plurality of different degrees of physiological response, and generate the data parameters through calculation and classification of the displayed images. For example, the detection system with identification label compensation function described in the second item of the scope of patent application, wherein the corresponding content of the second read message corresponding to the identification label is further used to reduce the difference between test strips and provide different calculation parameters for download. Reach the result of calibration and proofreading the observation area. For example, the detection system with recognition label compensation function as described in item 3 of the scope of patent application, wherein the corresponding content of the second read message of the recognition label is further provided as the validity period control of the test paper. For example, the detection system with identification tag compensation function described in the scope of patent application 2, wherein the cloud will receive the physiological response parameters with the detection results in the parameter package and the image of the test group, and store and collect the data. For example, the detection system with identification tag compensation function described in the first item of the scope of patent application, wherein the electronic device can be one of a smart phone, a tablet computer, a desktop computer, and a notebook computer. For example, the detection system with recognition tag compensation function described in the first item of the patent application, wherein the transmission interface control processor can respectively perform wired transmission through a USB connection slot and wireless transmission through Bluetooth or WIFI. For example, the detection system with identification tag compensation function described in the first item of the scope of patent application, wherein one of the external detectors has a detection panel with a power indicator light, a wireless connection indicator light, and a specimen Indicator light and a transmission indicator light.

Images