TWI621851B - Biosensor, terminal and method for measuring biometric information - Google Patents

Abstract

The present invention provides a method and apparatus for measuring biometric information. Place The method includes receiving an image of a biosensor, the biosensor including a reagent pad, collecting a sample on the reagent pad, and brightness information of a reaction zone of the reagent pad in the received image The reference brightness information in the received image is compared to determine a value of a reagent reaction between the reagent pad and the sample.

Description

Biosensor, terminal and side for measuring biological information law [Cross-Reference to Related Applications]

Korean Patent Application No. 10-2014-0152083 filed on November 4, 2014 at the Korea Intellectual Property Office and Korean Patent Application filed at the Korea Intellectual Property Office on November 3, 2015 The priority of the Korean Patent Application, the entire disclosure of which is hereby incorporated by reference.

Methods and apparatus in accordance with exemplary embodiments of the present invention are directed to measuring biological information from collected samples.

Methods for measuring biological information from samples collecting their own bodies have been continuously developed. Urine or blood can be collected for use as a sample, however, as this method continues to develop, a method of measuring biometric information about, for example, diabetes, has been developed for a self-sweat or tear sample. In addition, a method of measuring biological information from a sample collected from saliva or exhaled breath has been developed.

According to a method for measuring biological information from a sample, the biological information can be measured by the following qualitative analysis: positive or negative is determined by visually examining the reaction of the urine liquid with the reagent on the urine diagnostic strip. reaction.

About measuring biological information, using a variety of reagent reactions to diagnose various diseases. Furthermore, not only qualitative analysis of positive/negative responses but also quantitative analysis of the condition via the measured values is utilized.

Urine and/or blood can be used to obtain various information types such as diabetes level, acid level (pH) and protein level by reaction test, but the measurement used in this aspect. The components are provided according to the type of information to be measured. In addition, the measuring elements are medium to large in size, expensive, and require specialized knowledge and are therefore limited to use by experts such as medical personnel and medical technicians.

Therefore, home or portable measuring components that can be easily used by ordinary people have been actively developed, and methods for measuring biological information by inputting sample information to a portable terminal such as a smart phone have been made. Research.

A technique for analyzing a sample strip in which a sample is collected has been proposed in detail by an optical image sensor (for example, a camera) included in the terminal. Furthermore, in order to accurately analyze the reaction of the sample with the reagent pad attached to the strip, a method of obtaining an accurate color change level of the reagent pad by analyzing and calibrating the color change level has been actively studied.

However, the method of calibrating the color change level of the reagent pad by comparing the color change value with a standard color code may not perform the calibration accurately because the color may be displayed differently based on the illumination of the location of the measurement sample. For example, when the shadow of the user who measures the sample or the access terminal in the dark covers the strip, the camera sensor can erroneously recognize the color change value.

Furthermore, when the temperature of the reagent is significantly different from the room temperature in which the measurement is performed, the quantitative value of the quantitative reaction can be calibrated according to the temperature. In addition, when the reagent is sensitive to temperature, that is, when the color change level changes greatly with temperature, it is necessary to calibrate the quantitative value according to the temperature.

Accordingly, calibration methods are being developed for reducing various errors that can be produced in various measurement environments, as well as methods for obtaining accurate results by calibrating quantitative values based on brightness in reagent reactions.

The exemplary embodiments of the present invention address at least the above problems and/or disadvantages and other disadvantages not described above. In addition, one or more exemplary embodiments are not necessarily required to overcome the disadvantages described above, and the exemplary embodiments may not overcome any of the above problems.

According to an aspect of an exemplary embodiment, there is provided a method of measuring biometric information, the method being utilized by a terminal and comprising: receiving an image of a biosensor, the biosensor comprising a reagent pad, Collecting a sample on the reagent pad; and comparing brightness information of the reaction zone of the reagent pad in the received image with reference brightness information in the received image to determine between the reagent pad and the sample The value of the reagent reaction.

The method can further include determining the brightness information of the reaction zone of the reagent pad in the received image; and determining the reference brightness information in the received image.

The method can further include determining a result of the reagent reaction based on the determined value.

The method can further include identifying the biosensor based on identification (ID) information displayed on the biosensor in the received image; and based on the identified biosensing The information of the reagent is determined by the information of the reagent.

The identification information displayed in the received image may include at least one of a quick response code, a barcode, an image, and a body.

The method may further include: determining whether an expiration date of the biosensor has been exceeded, the expiration date is included in the identification information; and displaying the indication in response to the determination that the expiration date has been exceeded At least one of unavailability of the biosensor and ineffectiveness of the reagent reaction.

The method can further include determining a temperature of the sample based on temperature information indicated by a temperature gauge attached to the reagent pad in the received image.

The determining can include determining the value of the reagent reaction based on the determined temperature of the sample and temperature information of a reaction of the sample.

The temperature gauge can be configured to attach to at least one of a sample inlet of the reagent pad and the reaction zone of the reagent pad.

The method may further include determining whether the temperature of the sample is equal to or higher than a preset temperature; and displaying a message indicating that the sample is not measurable.

The method may further include determining whether the temperature of the sample is lower than or equal to a preset temperature; and displaying a message indicating that it is impossible to measure the sample.

The temperature gauge can be displayed on the reagent pad and has at least one of a linear shape, a radial shape, and a circular shape.

The method can further include measuring a room temperature using a temperature gauge included in the terminal.

The method can further include determining a room temperature indicated by a temperature sensor attached to the biosensor in the received image.

The reference brightness information may indicate different discrete brightnesses for the same color, and the comparing the brightness information of the reaction area may include: detecting first brightness information in the reference brightness information, the first The brightness information corresponds to the brightness information of the reaction zone; and the value of the reagent reaction corresponding to the first brightness information is determined.

The reference brightness information may indicate different continuous brightness for the same color, the different continuous brightness may be continuously disposed in the reference brightness information, and comparing the brightness information of the reaction area may include: detecting The first brightness information of the reference brightness information, the first brightness information corresponding to the brightness information of the reaction area; detecting a position of the first brightness information in the reference brightness information; And determining the value of the reagent reaction corresponding to the detected location.

The reference brightness information may indicate different discrete brightnesses for the same color, and comparing the brightness information of the reaction area may include detecting that the image includes the same brightness as a portion corresponding to the reaction area a region of the pixel of brightness; identifying a shape of the detected region; determining an actual brightness of the reaction region based on the identified shape; and determining the reagent response corresponding to the determined actual brightness The stated value.

The value of the reagent reaction may correspond to the color and brightness of the sample in a library stored in a reservoir of the terminal.

The reagent pad may further comprise a control line having a color that varies depending on the reagent reaction.

The biosensor can include a reagent pad that supports a reagent reaction between the reagent pad and the sample.

The method can further include identifying the biosensor based on a location of the reagent pad in the received image.

The biosensor can be used to analyze at least one of urine, blood, sweat, tears, saliva, and exhaled breath.

According to another aspect of the exemplary embodiment, there is provided a terminal for measuring biometric information, the terminal comprising: an input interface for receiving an image of a biosensor, the biosensor including a reagent pad Collecting a sample on the reagent pad; a reservoir for storing the received image; and a controller for using the brightness information of the reaction zone of the reagent pad in the received image with the received The reference brightness information in the image is compared to determine the value of the reagent reaction between the reagent pad and the sample.

The controller may be further configured to: determine the brightness information of the reaction area of the reagent pad in the received image; and determine the reference brightness information in the received image.

The controller may be further configured to determine a result of the reagent reaction based on the determined value.

According to an aspect of still another exemplary embodiment, there is provided a biosensor for supporting measurement of biometric information, the biosensor comprising: a reagent pad including a sample inlet for collecting a sample, and a reaction zone in which the collected sample is reacted; an identification information display area for displaying identification information of the biosensor; and a reference brightness display area for displaying different brightness information for the same color. The reaction zone serves to change color depending on the result of the reaction between the reaction zone and the sample.

The sample inlet can include a temperature gauge to measure the temperature of the collected sample.

The biosensor may further include a reference color display area to display different color information for the reaction zone.

The reaction zone can include a dye to change the corresponding color based on the result of the reaction between the reaction zone and the sample.

According to still another aspect of the exemplary embodiment, there is provided an apparatus for measuring biometric information, the apparatus comprising: an input interface for taking an image of a reagent pad, and collecting a sample on the reagent pad, the reagent The pad includes a region in which the sample reacts, and the reagent pad includes a reference brightness; and a controller to adjust a brightness of the region in the captured image to the image in the captured image The reference brightness is compared to determine the result of the reaction between the zone and the sample.

The device can further include a display to display the captured image and the result of the reaction between the region and the sample.

According to an aspect of still another exemplary embodiment, there is provided a method of measuring biometric information by a terminal, the method comprising: capturing an image of a biosensor, the biosensor comprising a reagent pad, the reagent Collecting a sample on the pad; transmitting the image to a server; receiving the biological information from the server, the biological information is obtained by using brightness information of a reaction zone of the reagent pad in the image The reference brightness information in the image is compared and determined; and the received biological information is displayed.

The exemplary embodiments are explained in more detail with reference to the accompanying drawings.

The exemplary embodiments of the present invention can be modified in various ways. Accordingly, the exemplary embodiments are illustrated in the drawings, However, it is to be understood that the invention is not intended to be limited to the exemplified embodiments, but all modifications, equivalents, and alternatives are included without departing from the scope and spirit of the invention. In addition, well-known functions or constructions are not described in detail, as they may obscure the invention in unnecessary detail.

In the following description, the same drawing reference numerals are used for the same elements even in different drawings. The matters defined in the description, such as the detailed description and description, Thus, it is apparent that the exemplary embodiments can be implemented without such explicit definitions.

The term "and/or" as used herein includes any and all combinations of one or more of the associated listed. For example, "at least one of", etc., when applied before a series of elements, is an element that modifies the entire series, rather than merely modifying the individual elements of the series.

Hereinafter, a method of obtaining biometric information and processing the biometric information from a biosensor that collects samples including biometric information by a terminal according to one or more exemplary embodiments will be described in detail.

FIG. 1 is a perspective view illustrating a terminal 100 and a biosensor 200, according to an exemplary embodiment.

The terminal 100 according to an exemplary embodiment includes an input interface 110. The input interface 110 can be an input interface including a module that can be manipulated by the user and also allows input of the user's image, voice, and text from the terminal 100, such as a button input interface when the terminal 100 includes a button or when the terminal 100 includes an optical image. Optical input interface for the sensor. In FIG. 1, terminal 100 includes a camera that receives an optical image on a rear surface and includes a non-contact temperature sensor 112 located below the camera. Since the non-contact temperature sensor 112 is also used to input an external temperature into the terminal 100, the non-contact temperature sensor 112 can be understood as the input interface 110 of the terminal 100.

The biosensor 200 is an element for collecting and analyzing samples including biometric information. Examples of samples including biometric information may include urine, blood, sweat, tears, saliva, and exhaled breath, and the biosensor 200 may be used to chemically or physically react between the reagent pad and the sample and the reagent pad is discolored. Or determine the condition of the user's body when displaying information.

Techniques for measuring the types of information of various organisms by exhaled breath are being developed. Since exhaled breath of a human or animal contains essential characteristics, exhaled breath can be used as a type of chemical breath. Since the exhaled gas not only emits carbon dioxide, but also emits volatile organic compounds such as acetone, toluene, nitrogen monoxide, or ammonia, it is possible to diagnose diseases such as diabetes by measuring the amount of discharge of each material in the exhaled breath. For example, since a normal person who does not have diabetes excretes about 900 parts of acetone gas of about 1 billion parts per billion (ppb), exhaled patients discharge about 1800 parts per billion by exhaled breath. Acetone gas, therefore, diabetes can be diagnosed by measuring the amount of acetone gas discharged.

Biosensors 200 (eg, exhaled breath sensors) can be utilized to diagnose various diseases such as diabetes, asthma, lung cancer, kidney disease, and heart disease, and, like diagnostic diseases, can be measured by measuring new buildings. The concentration of harmful substances (eg, toluene and formaldehyde) is used to determine sick house syndrome. Further, since acetone is mixed in the exhaled breath when the fat is burned, it can be judged whether or not the person running on the treadmill has a sufficient weight loss effect.

The exhaled breath is measured by measuring the amount of excretion of the substance in the exhaled breath, or alternatively, the color of the biosensor 200 can be altered based on the chemical or physical reaction (dye reaction) of the substance in the exhaled breath ( For example, the discoloration information at the time of color change according to the pH in the bromothymol blue (BTB) solution is measured. Thus, in accordance with an exemplary embodiment, a biosensor may be utilized to measure a sample collected from exhaled breath to measure biometric information.

The biosensor 200 according to an exemplary embodiment includes a sample inlet 210 and a control line 220 in which a sample is input to react with a reagent pad, and the control line 220 serves as a criterion for pairwise comparison of reactions on the reagent pad. The biosensor 200 further includes a test line 230, a reference brightness information display area 240, and an identification (ID) information display area 250. The test line 230 is used to directly determine the reaction between the reagent and the sample of the reagent pad, and the reference brightness information is displayed. The area 240 is used as a comparison object for determining the color and brightness level in the test line 230, and the identification information display area 250 is used to identify the identification information of the biosensor 200.

According to FIG. 1, the reaction between the sample and the reagent pad according to an exemplary embodiment enables a user of the terminal 100 to perform qualitative analysis based on the reaction result according to the discoloration of the control line 220 and the test line 230, and is also based on the color change level. Or a change in brightness to perform a qualitative analysis. For example, in a pregnancy test, pregnancy can be determined based on the discoloration of the control line and the test line.

As shown in FIG. 1, a biosensor 200 according to an exemplary embodiment includes a sample inlet 210 in which a sample is input for reaction between a sample and a reagent pad, wherein a sample input into the sample inlet 210 The reaction line 220 and the test line 230 of the reagent pad can be reacted according to an immunochromatography method.

The immunochromatographic method utilizes the reaction characteristics of an antibody with an antigen, wherein the antibody is a protein formed in the body to remove a pathogen entering the body, and the antigen is a material such as a pathogen that binds to the antibody. One type of antibody binds to a portion of an antigen. For example, when immunochromatography is applied to a pregnancy test, human chorionic gonadotropin (HCG) excreted from blood or urine after pregnancy is used as an antigen to prepare a human chorionic gonadotropin. Two antibodies that bind to hormones. One type of antibody is attached to reddish purple gold particles, while another type of antibody is immobilized on a thin plate of linearly shaped nitrocellulose membrane. Since the antibody is an invisible protein, no color is shown in the test line immobilized on the nitrocellulose membrane.

When urine is dropped on human chorionic gonadotropin, the antibody immobilized to the gold particles binds to human chorionic gonadotropin and acts through the nitrocellulose membrane by capillary action. When an antibody that binds to human chorionic gonadotropin passes through a test line, an antibody that binds to human chorionic gonadotropin binds to an antibody immobilized to a nitrocellulose membrane, and thus the gold particles form a red-violet linear shape, thereby borrowing The pregnancy is determined by visually determining such discoloration. When human chorionic gonadotropin is not included in the urine, human chorionic gonadotropin does not bind to the antibody in the test line, and no line is shown, and thus the user can determine that it is not pregnant.

At the same time, the test endpoint line (also referred to herein as "control line"), whether or not the pregnancy is always indicated, is a line that is designed to be shown regardless of the presence or absence of human chorionic gonadotropin. The test endpoint is also a line that utilizes the reaction between the antigen and the antibody, and displays to the user information that the bar function is normal and that the user can determine the result because the test has been completed.

In the above, immunochromatography methods have been applied to pregnancy tests, but it will be apparent to those of ordinary skill in the art that immunochromatography can also be used to diagnose ovulation, hepatitis, AIDS, and the like.

FIG. 2 is a view illustrating a reagent pad to which a temperature measuring device 215 is attached, according to an exemplary embodiment.

The biosensor 200 according to an exemplary embodiment includes a temperature gauge 215 at the sample inlet 210. Since the temperature of the sample can be used as a variable when measuring biological information, the temperature of the sample can be accurately measured. The area of the biosensor 200 that accurately measures the temperature of the sample separated and collected by the body is the sample inlet 210. The sample inlet 210 is the zone in which the sample is collected directly, since it is highly probable that the temperature of the sample measured at the sample inlet 210 is not different from the temperature of the body.

The sample inlet 210 according to an exemplary embodiment is part of a reagent pad, and when a sample is placed in the sample inlet 210, the components of the sample are moved from the sample inlet 210 to the reaction zone by an immunochromatographic method (reagent pad The area is the area including the control line and the test line). Therefore, the sample inlet 210 can be kept at a certain distance from the reaction zone. If the sample inlet 210 and the reaction zone are relatively close relative to each other and the sample is in direct contact with the reaction zone, the reagent reaction at the control line and test line that is the reaction zone may not be properly obtained.

Sample inlet 210 can receive (collect) samples by any of a variety of methods. As shown in FIG. 2, the sample can be placed into the sample inlet 210 of the biosensor 200 by instilling the sample with a syringe or by immersing the biosensor 200 directly into the liquid sample.

3 (including portions (a) and (b) of FIG. 3) is a diagram illustrating various positions of the temperature measurer 215 according to an exemplary embodiment.

As shown in FIG. 3, temperature gauge 215 can be attached to sample inlet 210 in a variety of manners. In FIG. 3, the temperature measurer 215 is attached to the sample inlet 210 in the form of a temperature band, but the temperature measurer 215 is not limited thereto, but may take any of various forms.

As shown in part (a) of Figure 3, a temperature gauge 215 is attached to the edge of the sample inlet 210. The temperature measurer 215 can measure the temperature within a certain range and display the measured temperature using a classification or scale. Temperature gauge 215 can be used to display colors that vary with temperature.

To allow the color to change with temperature, the temperature gauge 215 can utilize a thermochromic ink. For example, a thermochromic ink can be applied to the surface of the beer can to change the color of the surface to a certain color, thereby informing the consumer of the proper temperature. The thermochromic ink is prepared by mixing a thermochromic material that discolors at a certain temperature. Examples of the thermochromic ink may include a color reversible ink that changes color depending on temperature and then returns to the original color, and an irreversible ink that cannot be restored to the original color after discoloration. The temperature measurer 215 according to an exemplary embodiment may utilize a color reversible ink to determine the temperature of the sample. Such a thermochromic ink can be prepared by using a stilbene derivative which is an organic compound as a raw material.

The temperature gauge 215 according to an exemplary embodiment may be printed in the form of a linear band using a thermochromic ink corresponding to the grading of the measurable temperature range, and when the sample is placed in the sample inlet 210, the temperature measurement The 215 can be discolored at a certain temperature to enable the user to visually determine the temperature of the sample.

As shown in part (b) of Figure 3, the temperature gauge is designed to be located at the center of the sample inlet. When the temperature gauge is at the center of the sample inlet, the temperature gauge can contact the sample over a large area, and the user can easily visually inspect the temperature of the sample as compared to when the temperature gauge is at the edge of the sample inlet. . However, when the temperature measuring device is located at the center of the sample inlet, the movement of the sample when using the immunochromatographic method can be hindered, and thus the temperature measuring device can be carried out under consideration of the influence of its position on the movement of the sample. Positioning.

4 is a cross-sectional view of a sample inlet 210 of a reagent pad, in accordance with an exemplary embodiment.

Referring to Figure 4, in the reagent pad, the sample inlet 210 and the reaction zone are connected to each other, and thus the reagent reaction can be detected by immunochromatography. A temperature gauge 215 for measuring the temperature of the sample 400 is attached to the top of the sample inlet 210 of the reagent pad to directly measure the temperature of the sample 400. In FIG. 4, sample 400 contacts temperature gauge 215 without contacting sample inlet 210, which is part of the reagent pad, but it will be apparent to those of ordinary skill in the art that sample 400 is in direct contact for reagent reaction. Reagent pad. Thus, the sample 400 can be in direct contact with the sample inlet 210 of the reagent pad, and the temperature gauge 215 can be attached to the top of a portion of the reagent pad. Regarding the method of using the thermochromic ink, the details of the method of the temperature measuring device 215 have been explained above with reference to FIG.

FIG. 5 is a view of a temperature gauge 525 attached to a reaction zone of a reagent pad, in accordance with an exemplary embodiment.

As shown in FIG. 5, temperature gauge 525 is designed to be located adjacent the reaction zone of reagent pad (eg, control line 220 and test line 230). Therefore, the temperature of the reaction in the test line 230 of the reaction zone is measured, and by obtaining the temperature of the reaction, the accuracy of obtaining the quantitative value of the sample can be improved.

The temperature of the sample in the reaction zone in which the reaction takes place is a variable when calibrating the quantitative value. Since the temperature in the control line 220 and the test line 230 is the temperature at which the reagent and the sample react with each other to change the color of the test line 230, the temperatures in the control line 220 and the test line 230 are similarly obtained theoretically in the terminal. The temperature of the reagent reaction (the temperature of the quantitative reaction) can be applied to the measurement of the reagent reaction theory. The terminal can compare the measured temperature to the temperature in the quantitative reaction and can perform a pairwise comparison with the quantitative value in the quantitative reaction, thereby reducing errors due to the measurement of environmental conditions.

The temperature gauge 525 at the control line 220 of the reagent pad and at the test line 230 can be designed to be located further from the sample inlet than the control line 220. The reaction zone can be the entire adjacent area of control line 220 and test line 230, and temperature gauge 525 can be designed to be located further from control line 220 such that temperature gauge 525 does not affect the immunochromatographic method. Reagent reaction. However, the position of the temperature measuring device 525 is not limited thereto, but the temperature measuring device 525 can be attached to the vicinity of the control line 220 and the control line 230 as long as the temperature measuring device 525 does not obstruct the sample and the test line 230 and the control line. The reagent reaction between 220 can be.

FIG. 6 is a view of a biosensor 200 with temperature measuring devices 615, 625, and 635 attached to measure room temperature, in accordance with an exemplary embodiment.

As shown in FIG. 6, temperature gauges 615 through 635 can be located at various locations of biosensor 200. The temperature gauge 615 can be located at the sample inlet as described above with reference to Figures 2 through 4 to measure the temperature of the sample, or the temperature gauge 625 can be positioned near the reaction zone of the reagent pad as described above with reference to Figure 5 The temperature at which the reagent reacts.

In the biosensor 200 according to an exemplary embodiment, the temperature measurer 635 may be separated from the reagent pad and attached to the biosensor 200 to measure the room temperature. The temperature sensor 635 attached to the biosensor 200 is not used to measure the temperature of the sample, but can be used to measure the temperature of the location where the reagent reaction is performed, ie, room temperature. Thus, if room temperature is measured via another method (eg, if the room temperature is measured by a terminal including a temperature sensor), the temperature gauge 635 attached to the biosensor 200 may not be present.

Temperature gauge 635 attached to biosensor 200 can be used to measure the temperature of the reaction zone, depending on the circumstances. If temperature gauge 625 is not attachable to the reaction zone of the reagent pad, temperature measure 635 can be located on biosensor 200 near the reaction zone to measure the temperature of the reagent reaction of the sample.

Figure 7 (comprising parts (a), (b) and (c) of Figure 7) is a diagram illustrating various types of temperature gauges in accordance with an exemplary embodiment.

The temperature gauge according to an exemplary embodiment may be attached to the biosensor in any of various forms. The temperature gauge can be attached to the biosensor in the form of a tape (eg, a temperature band) or can be printed on the biosensor during the biosensor manufacturing process. The temperature band can be prepared using the above thermochromic ink, and a temperature measuring instrument having color reversible characteristics can be used to measure the temperature of the sample, wherein the color changes at a temperature equal to or higher than a certain temperature, and is lower than The temperature is restored to the original color at the temperature.

As shown in part (a) of Figure 7, a wire temperature gauge can be attached to the biosensor. The linear temperature gauge has a form similar to that of a mercury thermometer that is commonly used, and provides an environment for the user of the biosensor to intuitively measure the temperature. The linear temperature gauge can display a rating within a measurable temperature range, and the zone of the linear temperature gauge corresponding to the measured temperature can be discolored to show the value of the measured temperature in color number. As shown in part (a), when the classification is shown at intervals of 2 ° C and the measured temperature is 22 ° C, the temperature of 20 ° C and 24 ° C around 22 ° C as the measured temperature can be set from 22 ° C. differentiate. Further, when three grades of color change from 20 ° C to 24 ° C are used, the measured temperature can be determined as an average value of the maximum temperature and the minimum temperature at the level of the color change. The user can set the color change of the linear temperature gauge in various ways to determine the measured temperature.

As shown in part (b) of Figure 7, a circular temperature gauge can be attached to the biosensor. The circular temperature gauge is obtained by rounding the shape of the linear temperature gauge of part (a), and since its principle is similar to a linear temperature gauge, its details are no longer provided.

As shown in part (c) of Figure 7, a temperature gauge that discolors only at a certain temperature can be attached to the biosensor. Such a temperature gauge can be used under the restriction that the reagent and the sample react with each other at a certain temperature.

FIG. 8 (including portions (a) and (b) of FIG. 8) is a diagram illustrating a temperature gauge of the terminal 100 according to an exemplary embodiment.

Referring to parts (a) and (b) of FIG. 8, the terminal 100 measures the room temperature of the environment in which the measurement is performed using the temperature sensor 810 included in the terminal 100. The terminal 100 (eg, a smart phone or a personal computer (PC)) typically includes a temperature sensor and a humidity sensor, and the temperature inside or outside the terminal 100 is measured using a temperature sensor.

As shown in parts (a) and (b) of FIG. 8, the temperature sensor 810 can be located at a certain position of the terminal 100, and the terminal 100 can determine the room via the measured value input by the temperature sensor 810. temperature. Such a temperature sensor 810 can be included in the terminal 100 in any of a variety of forms, as will now be described in detail with reference to FIG.

Figure 9 (including parts (a), (b), (c), (d) and (e) of Figure 9) illustrates various elements for measuring the temperature and room temperature of a sample according to an exemplary embodiment. Figure.

As shown in parts (a), (b) and (c) of Figure 9, the temperature gauge can be included in any type of terminal (e.g., smart phone, tablet personal computer or wearable component) to measure temperature.

As shown in part (d) of Fig. 9, the terminal can measure the room temperature by including an infrared ray (IR) thermometer. The infrared temperature measurement measures infrared rays radiated from an object having heat, and since the infrared radiation energy radiated from the surface of the object propagates through the space, the infrared thermometer can measure the temperature of the object without contacting the object. Examples of the infrared thermometer include a monochromatic infrared thermometer and a ratio type infrared thermometer that measures infrared radiant energy with respect to a wavelength, and the ratio type infrared temperature measures two wavelengths The type of radiation intensity ratio. A suitable infrared thermometer can be used depending on the measurement of the sample. The terminal converts the radiation intensity input through the infrared detector into heat to increase the temperature of the thermal detector, converts the changed temperature of the thermal detector into an electrical signal, and amplifies the electrical signal to display the amplified power. The sex signal is used as the measured temperature.

As shown in part (e) of Figure 9, the terminal may include a laser thermometer to measure the temperature. Lasers are a type of light, and laser thermometers can measure temperature using photoconductive or photodiode semiconductors. The temperature may be measured based on the intensity of light radiated via a change in resistance corresponding to temperature or a change in current or voltage.

Further, according to an exemplary embodiment, the terminal may include a thermal image camera to measure temperature via the thermal image camera. Thus, if the terminal is capable of performing the function of measuring temperature, such a terminal can perform the temperature measurement of the disclosed embodiment.

FIG. 10 is a diagram for explaining a terminal that photographs an image of a biosensor, according to an exemplary embodiment.

After collecting the sample at the sample entrance, the terminal can receive the image of the biosensor by taking an image of the biosensor. The terminal receives the information displayed on the biosensor in the form of an image, and can analyze the received information to determine the reaction result of the sample.

As described above with reference to FIG. 1, the biosensor can display the color change information, the reference brightness information, and the identification information in the reaction area of the reagent pad, and the terminal can use the camera sensor or the detector to obtain the biological sense. Information on the detector. For example, when a temperature measuring device for measuring room temperature is attached to a biosensor and the temperature measuring device displays temperature, the terminal can be read via optical character recognition (OCR) The temperature.

Upon receiving the image of the biosensor, the terminal may store the metadata of the image along with the image. When the terminal uses an optical image sensor (camera) or a detector to capture images of the biosensor, the terminal can measure the time, position, temperature, humidity, atmospheric pressure, and illumination simultaneously or sequentially. Information and store the measured information as metadata of the image. The storage of the terminal can prepare a database of metadata (database, DB) according to each item, and the item can be used as a variable when the image is subsequently analyzed.

In addition, since the identification information included in the image may include not only the biosensor's own identification information but also various information types, the terminal may analyze the identification information to obtain measurement related information. The identification information will be explained in detail later with reference to FIG.

FIG. 11 is a view illustrating biosensor 200 displaying reference brightness information 1140, according to an exemplary embodiment.

As shown in FIG. 11, the biosensor 200 displays reference brightness information 1140. The reference brightness information 1140 is information in which colors are arranged according to the brightness level. The color may be the same as or similar to the color of the color of the test line of the reaction zone of the reagent pad depending on the reaction. Therefore, when a reaction occurs, the brightness information of the color change color of the test line can be compared with the reference brightness information 1140 for calibration.

The terminal can compare the brightness information of the color change color of the test line with the reference brightness information 1140 displayed on the biosensor 200, and determine the brightness level of the color change color based on the reference brightness information 1140. The quantitative value of the quantitative reaction can be derived from the level of reference brightness.

The reference brightness information 1140 displayed on the biosensor 200 arranges the brightness values of one color according to the degree, and in the technical field, the brightness is divided into eleven levels, wherein the level of the darkest color is 0 and the brightest color The level is 10. However, brightness is not only divided into eleven levels, but can be divided into more levels for accurate comparison.

In addition, since the brightness is related to the reflectance, the actual brightness of the color is a factor, but the illumination environment is also a factor when measuring the brightness of the color. Therefore, the brightness of the color in the test line of the biosensor 200 can be compared to the reference brightness information 1140 for calibration.

The reference brightness information 1140 is information displayed on the biosensor 200 and may also be changed according to illumination. Therefore, the terminal can compare the brightness of the color in the test line with the brightness of the reference brightness information 1140 to calibrate the brightness of the color in the test line so that the illumination does not affect the brightness of the color in the test line.

12 (including portions (a), (b), and (c) of FIG. 12) is a diagram illustrating reference luminance information that varies according to colors according to an exemplary embodiment.

As shown in parts (a), (b), and (c) of Figure 12, various reference brightness information types can be displayed on the biosensor. In parts (a), (b), and (c), the reference brightness information differs only in the brightness of the color, wherein the color is brighter from 5 to 1.

As shown in part (a) of Fig. 12, the division and display of the brightness of the first color can be performed in various ways. Here, the brightness is divided into five levels from the first level to the fifth level, wherein the first level is the brightest level. Alternatively, the brightness can be divided into at least two levels and the brightness level of the brightness of the color-changing color closest to the test line can be determined. In order to determine the closer brightness as possible, the brightness level can be divided as finely as possible so that the terminal can accurately compare the brightness.

Manufacturers of biosensors can design biosensors to display reference brightness information for at least two colors. If the number of types of reagent mats used in the reaction is at least two, reference brightness information of at least two colors may be displayed, but reference brightness information of at least two colors may also be displayed for one reaction zone to pass accurate brightness. Compare to get a quantitative value. For example, when the color change color after the reaction on the reagent pad is green, green reference brightness information can be displayed on the biosensor, and at the same time, yellow or blue color having high color similarity to green can be displayed. The reference brightness information is provided to provide various criteria for brightness comparison, thereby improving the accuracy of the brightness comparison.

FIG. 13 is a flowchart of a method for measuring biometric information by an image of a biosensor by a terminal, according to an exemplary embodiment.

In operation S1310, the terminal receives an image of a biosensor (eg, a urine diagnostic strip) including a reagent pad in which the sample is collected. For example, the terminal can utilize an optical image sensor (camera) to obtain an image of the biosensor. The image may include at least one of color change information, reference brightness information, and identification information in a reaction zone of the reagent pad. As shown in parts (a), (b), and (c) of Fig. 15, the identification information can be displayed as a QR code, a bar code, or a body text. Therefore, the terminal can obtain various types of information about the reagent reaction by analyzing the received image.

In operation S1320, the terminal detects color and brightness information of the test line of the reagent detecting reagent pad from the received image.

The terminal can determine the discoloration of the test line of the reaction zone on the received image. For example, the test line can be discolored from white to red after the reagent reaction, and the terminal can determine the discoloration using RGB values or CMYK values corresponding to the color of the test line.

In addition, the terminal can detect the brightness of the color. The detected brightness can be determined to be in the range from the darkest level (black) to the brightest level (white), and the memory of the terminal can pre-store information corresponding to the brightness level of each color. Alternatively, the terminal's storage may pre-acquire information corresponding to the brightness level of each color from the server and store the information.

In operation 1330, the terminal compares the detected or determined brightness information of the test line with the reference brightness information in the received image to obtain a quantitative value of the reagent reaction of the sample.

The terminal can detect color and brightness in operation S1320. The terminal can pre-store the brightness of the test line in a fixed number of reactions. The terminal can derive a quantitative value corresponding to the reagent reaction by comparing the brightness in the fixed number of reactions with the detected brightness of the test line. The terminal's memory can pre-store information about the brightness in a fixed number of reactions. Alternatively, the terminal may request external components to obtain such information and then receive the information from the external component.

Whether the quantitative value increases or decreases with the brightness of the test line can be judged according to the type of the sample. The terminal can detect the same or the most similar brightness as the detected brightness of the test line from the reference brightness information of the same color as the detected color of the test line.

The reference brightness information displayed around the reaction area of the biosensor can be utilized to reduce detection errors due to illumination. Therefore, when the illumination changes, both the reference brightness information and the detected brightness of the test line change simultaneously, and thus the detection error due to the external environment can be reduced. According to the color correction method, factors such as external illumination are not considered when comparing the reference color with the color of the test line, and therefore, the terminal can erroneously determine the color at which the discoloration occurs according to the actual reagent reaction. However, according to an exemplary embodiment, since the brightness of the test line is compared under the same condition as the reference brightness information, the detection error due to external illumination can be reduced.

The terminal can compare the detected brightness with the reference brightness information to obtain a relative difference of the detected brightness with respect to the brightness in the fixed number of reactions as a quantitative value. For example, the terminal can detect that the color of the test line is red. In addition, the terminal can detect that the brightness of the color of the test line (ie, red) is the second level (ie, the second brightest) of the five levels of brightness of the reference brightness information. Meanwhile, in the database stored in the terminal, the brightness in the fixed number of responses may be the third level (ie, the third brightest) of the five levels of the brightness of the reference brightness information. Since the difference between the brightness of the test line (second level) and the brightness in the fixed number of reactions (third level) is a level, the terminal can obtain the detected brightness (second level) relative to the fixed amount. The relative difference in brightness (third level) is used as a quantitative value of "one level".

In operation S1340, the terminal determines the reaction result of the sample based on the obtained quantitative value. For example, when the detected brightness of the test line is brighter, the value corresponding to sample A can be lower. When the detected brightness of the test line is brighter than the brightness in the fixed number of reactions, it can be determined that the value corresponding to the sample A is lower than the reference value. Further, the terminal can derive a value corresponding to the sample A as a result of the reaction of the sample A. The difference between the obtained value and the reference value may correspond to the difference between the detected brightness of the test line and the brightness in the fixed number of reactions.

Information about the brightness in the fixed number of reactions and the reference value of each sample can be pre-stored in the terminal. Alternatively, the terminal may request external components to obtain such information and receive the information from the external component.

The terminal can detect the color changed by the reaction between the reagent pad and the sample from the received image. The detected color can be stored in RGB format or CMYK format. In addition, the brightness of the detected color can be detected and stored.

The color and brightness detected from the received image may be different from the actual color and actual brightness of the reagent pad. Therefore, in order to accurately detect the brightness of the test line, the terminal can compare the brightness of the test line of the received image with the reference brightness information of the received image. Furthermore, the relative difference in brightness of the test line relative to the brightness in the fixed number of reactions can be derived as a quantitative value based on information about the brightness in the fixed number of reactions.

The terminal can analyze the reaction results of the collected samples based on the color of the reaction zone of the reagent pad and the resulting temperature. Since the reaction zone includes the control line and the test line, it is determined whether the biosensor is in a normal state based on whether the control line is discolored according to the reagent reaction. Since the control line undergoes discoloration when the sample is input to the control line, if the control line does not change color even when the sample is input, the biosensor can be determined to operate improperly and the normal reaction cannot be determined. In this case, the terminal can receive an image of the biosensor in which the control line does not change color, and inform the user that the biosensor is invalid.

When the test line is discolored according to the reagent reaction, that is, when a positive reaction is generated in the test line, the terminal can receive an image of the biosensor in which the test line is discolored. Therefore, the terminal can perform qualitative detection based on the color change and perform quantitative detection based on the color change level.

The terminal can perform quantitative analysis based on the color level of the reagent pad of the received image. The quantitative analysis can be performed by comparing the color and brightness of the test line of the received image with the reference brightness information. The terminal's memory stores a database of temperature, color, and brightness in a fixed number of reactions, and the terminal can compare the temperature, color, and brightness of the test line with the temperature, color, and brightness in the database to detect The value of temperature, color, and brightness in the test agent reaction. The memory of the terminal, cloud or server can store calibration curves or line values that vary according to each temperature, and thus the values can be calibrated based on the detected temperature.

To more accurately derive a quantitative value and determine the result of the reaction in operation 1330 and operation 1340, reference may be made to the temperature measured by the temperature sensor of the biosensor or terminal. As described above with reference to FIGS. 6, 8, and 9, the temperature gauge 635 can be utilized to obtain reference temperature information indicative of room temperature, or the temperature sensor of the terminal can be utilized to obtain the reference temperature information.

Alternatively, the terminal can obtain reference temperature information by accessing the network. The terminal can be connected to a network element, such as another terminal or server, via a communication interface. The terminal can obtain temperature information measured by another terminal located in the same room and connected via a network. The terminal can determine the location of the terminal by using a location sensor (such as a global positioning system (GPS)) included in the terminal or by using a Wi-Fi access point (AP) located in the room. Then, the terminal can receive the room temperature information from the server of the weather center according to the location of the terminal, and apply the room temperature information as the reference temperature information.

The terminal can not only store the discoloration information in a fixed number of reactions in the storage, but also store the appropriate temperature information in a fixed number of reactions in the storage. Since the discoloration may vary with temperature depending on the reagent reaction, the room temperature in the space in which the reagent reacts and the temperature of the sample in the reaction zone may be variables. For example, when a test line that appears white before the reagent reaction reacts with the sample, the test line can be discolored to red at room temperature of 25 ° C (ie, a suitable temperature for a fixed amount of reaction), at room temperature below 15 The color changes to a reddish color at a temperature of ° C, and discolors into a deep red color at a temperature of 35 ° C above room temperature. As another example, when the temperature of the sample is 25 ° C, the test line can change color to blue in the reagent reaction, but can be in a fixed amount when the sample itself undergoes a chemical reaction at a higher temperature (for example, 35 ° C). The reaction changes to a different color in a different reaction.

Therefore, the terminal can detect the quantitative value by comparing the discoloration information, brightness, and temperature of the reagent reaction on the received image with the discoloration, brightness, and temperature in a fixed amount of reaction. The terminal can detect the quantitative value by matching the result of the reagent reaction with the data in the database in which the data is divided according to the reference brightness information and the discolored temperature information.

FIG. 14 is a graph illustrating a change in luminance value according to a temperature of a sample, according to an exemplary embodiment.

The level of color change for each sample can vary depending on the temperature. As described above, information about the color and brightness that varies depending on the temperature can be stored in the terminal or cloud (server) or received from another terminal. The terminal can compare the color and brightness according to the temperature with the stored information to obtain a quantitative value corresponding to the reagent reaction.

For example, as shown in FIG. 14, the luminance according to the concentration at a temperature of 22 ° C and the luminance according to the concentration at a temperature of 37 ° C vary at different rates. In this case, if only the discoloration and brightness in the image of the biosensor are analyzed, the temperature of the sample is 22 ° C and the brightness of the sample is 4 and the temperature of the sample is 37 ° C and the concentration of the sample. The brightness at 1 is the same, and thus a erroneous quantitative value can be derived. However, if the terminal stores a database based on the brightness value of the concentration at 22 ° C and 37 ° C, the terminal can determine the brightness at a temperature of 22 ° C and a concentration of 4 and a temperature of 37 ° C and a concentration of 4 The difference between the two, and therefore can give an accurate quantitative value.

15 (including portions (a), (b), and (c) of FIG. 15) is a diagram illustrating an identification display indicating identification information of a biosensor according to an exemplary embodiment.

The identification information may be displayed in the form of a QR code as shown in part (a) of Fig. 15 or in the form of a bar code as shown in part (b) of Fig. 15. Alternatively, the identification information may be displayed in the form of a text including a number and/or a character as shown in part (c) of FIG. Identification information can be displayed in the form of an image (eg, a symbol). The identification information is not limited as long as it is displayed in a form recognizable by the biosensor.

The biosensor's identification information can include various types of information. The identification information may include not only information about the biosensor itself, but also information about the qualitative/quantitative response in the biosensor. Identification information may include information that the test line is discolored into red due to reagent reaction and reagents are used to analyze diabetes or protein.

Thus, the terminal can analyze the identification information contained in the received image of the biosensor to determine the use of the biosensor, the manufacturer of the biosensor, the date of manufacture of the biosensor, and the biosensing Information about the expiration date of the device.

Such information can be determined by analyzing the displayed identification information or by using a database stored in the terminal's storage for analyzing the identification information. In other words, information about the purpose, manufacturer, and expiration date can be encoded and displayed as identification information, or the terminal can determine the usage, manufacturer, and expiration date by searching the database pre-stored in the terminal via the identification information. News.

In addition, the terminal can transmit information related to the identification information to the server and obtain information indicated by the identification information from the server. The terminal may request the server associated with the manufacturer to obtain additional information about the identification information, and the server associated with the manufacturer may provide the additional information to the terminal.

In detail, the biosensor's identification information may include essential information about the user. The user can be the person who provides the sample (ie, the target). The identification information may include the user's periodic measurement of the biological information or the measurement of the biological information to diagnose the user's previous measurement information.

For example, when the user wants to measure the level of diabetes via the sample collected on the biosensor, the terminal can obtain the identification information by analyzing the received image of the biosensor, and the identification information is obtained. Transfer to the hospital server. Upon receipt of the identification information, the hospital server can provide the terminal with information about the user's past diabetes levels. Therefore, the terminal can determine the change in diabetes level based on information received from the hospital server. A method of using a server to obtain various types of information will be described in detail below.

FIG. 16 is a diagram for explaining a reaction of a reagent pad with a sample according to an exemplary embodiment.

As shown in Figure 16, an antigen-antibody reaction is produced in the reaction zone of the reagent pad. Control lines and test lines including antigens or antibodies can be printed on the reaction zone. The reaction with the sample input to the reaction zone can occur in the control line and the test line. The light source is present in the space in which the reaction takes place. For example, when a reaction is generated within a building, there may be an artificial light such as a fluorescent lamp. Since the terminal obtains an image of the biosensor in which the reaction is generated, the color or brightness of the image may be different from the actual color or actual brightness based on the light source.

Since the terminal detects the biological information based on the color change of the control line and the test line of the biosensor, the detected biological information may be changed based on the color change and brightness of the control line and the test line. In detail, as shown in FIG. 16, when a sample (for example, saliva or urine nanoparticle) is used to perform several reagent reactions, discoloration and brightness may vary depending on the reagent reaction, and thus the calibration may be performed. Detect quantitative values.

A method of calibrating a quantitative value based on temperature as a method of calibrating a quantitative value will now be described.

17 is a graph showing changes in obtained product obtained when a reagent pad is reacted with a sample, as a function of temperature, according to an exemplary embodiment.

The reaction temperature may also be a variable that affects the reaction result in the reagent reaction. Fig. 17 is a graph showing changes in the quantitative value according to the reaction temperature of the pressure hormone cortisol. In the graph shown in Fig. 17, the quantitative value according to the pressure hormone cortisol was measured for a total of six patients, and when the reaction temperature was increased, the amount of pressure due to the hormone cortisol was increased.

According to Fig. 17, the quantitative value is changed depending on the reaction temperature in a fixed amount of reaction, as the reaction speed of the antigen and the antibody changes, and the quantitative measurement element prevents the quantitative value from being changed by uniformly maintaining the temperature. However, the terminal according to an exemplary embodiment is a small terminal that is easy to carry, and thus it is difficult to include an element to uniformly maintain the temperature. Therefore, it may be difficult for the terminal to prevent the quantitative value from changing with temperature.

A method of calibrating the quantitative value will now be described, while stating that the temperature of the sample and the temperature in the fixed amount of reaction can be variables in the reagent reaction.

FIG. 18 is a graph showing temperature of a sample and a calibrated temperature, according to an exemplary embodiment. Figure 18 is a graph showing the results of a B-type natriuretic peptide (BNP) assay of a sample according to an exemplary embodiment. Referring to FIG. 18, the fluorescent unit corresponding to the sample capturing area is different from the fluorescent unit corresponding to the calibration shooting area. In other words, the quantitative values associated with the actual reaction in the test line corresponding to the sample capture zone may be different from the quantitative values associated with the fixed number of reactions corresponding to the calibration capture zone.

19 and 20 are graphs of values before and after calibrating the temperature of a sample, in accordance with an exemplary embodiment.

The vertical axis of the top view of Fig. 19 indicates the R10 value, which is an internal standard line in the calibration shot area in the test line (TL) indicating a sample shot area and a fixed number of reactions. The value of the ratio of ISL) can be obtained according to Equation 1 below. (1)

Based on the X-axis of the top graph of Fig. 19, when the amount of the sample is 0, the left vertical bar graph is the R10 value of the reagent, and when the sample amount is 10 ng/ml (ng/ml), the right vertical strip The graph is the R10 value of the reagent. Further, when the temperature is 22 ° C, the left side bar of the vertical bar graph is the R10 value of the reagent, and when the temperature is 37 ° C, the right side bar of the vertical bar graph is the R10 value of the reagent. As shown in the top view of Fig. 19, as the amount of the sample increases, the value of R10 increases, and when the temperature increases, the value of R10 decreases. In other words, the resulting value of the reagent reaction varies depending on the temperature.

The middle view of Fig. 19 is a view showing the reagent value of the test line (TL), and the bottom view of Fig. 19 is a view showing the reagent value of the internal standard line (ISL) in the fixed number of reactions. In the middle diagram shown in Fig. 19, as the reagent value of the test line increases, the amount of the sample increases. When the amount of the sample is 0, the value of the test line which varies according to the temperature is not significantly different. When the amount of the sample is 10 ng/ml, the value of the test line which changes according to the temperature greatly changes. Similarly, in the bottom view shown in Fig. 19, when the amount of the sample is 10 Ng/ml, a large change occurs in the internal standard line value which varies depending on the temperature.

The top graph of Figure 20 shows the R10 value after calibrating the temperature with respect to the R10 value of the top graph shown in Figure 19. After the temperature is calibrated, when the amount of the sample is 0, the R10 value at a temperature of 22 ° C is higher than the R 10 value at a temperature of 37 ° C, and when the amount of the sample is 5 Ng / ml, the R 10 value is similar, and When the amount of the sample was further increased, the R10 value at a temperature of 37 ° C was higher than the value of R 10 at a temperature of 22 ° C. Therefore, the sample is accurately measured by calibrating the quantitative value. The middle and bottom graphs shown in Figure 20 show the test line values and the internal standard line values, respectively, and also support accurate measurement of the samples via calibration.

21 and 22 are flowcharts of a method of determining whether the temperature of a sample is within a range of an appropriate temperature, according to an exemplary embodiment.

As described above, the reagent reaction is an antigen-antibody reaction in which the reaction temperature is a factor. Thus, reactions within a range of temperatures can achieve accurate measurements of quantitative values, and normal reactions may not occur at temperatures outside the range, as antigens or antibodies have been altered.

The terminal can determine the temperature or reaction temperature of the sample by analyzing the received image of the biosensor, and can also obtain the temperature in the fixed number of reactions via at least one of various ways.

Therefore, the terminal can determine whether the reagent reaction is effective by comparing the determined temperature of the sample with a preset range of the appropriate temperature. In operation S2110, the terminal determines the temperature of the sample by analyzing the temperature indicated by the temperature gauge on the received image of the biosensor. For example, when the temperature indicated by the temperature gauge is 22 ° C, the terminal can determine that the temperature of the sample is 22 ° C.

In operation S2120, the terminal determines whether the temperature of the sample is equal to or higher than a preset temperature. If the sample has a normal reagent reaction at a temperature equal to or higher than 20 ° C, it is difficult to obtain a normal reagent reaction of the sample when the temperature is 0 ° C or 5 ° C. Therefore, the temperature of the sample can be determined to determine if a normal reagent response is available. When the terminal determines that the temperature of the sample is equal to or higher than the preset temperature, the terminal proceeds to operation S2130. When the terminal determines that the normal reagent reaction cannot be obtained, the terminal proceeds to operation S2140.

In operation S2140, the terminal displays a message indicating that the measurement is not measurable or should be retested on the display area.

In operation S2130, the terminal obtains a quantitative value by calibrating the temperature, and at this time, accurate measurement can be performed by the color and brightness of the test line.

As in the method of Fig. 21, in the method of Fig. 22, the terminal can be set to calibrate the temperature only when the temperature is lower than or equal to a certain temperature. Since the components of the antigen and the antibody are highly likely to be similar to the components of the body's tissues, when the temperature of the sample exceeds a certain temperature, the antigen or antibody can be deformed at a temperature higher than a certain temperature, and thus the normal reagent reaction may not be obtained. . Thus, the terminal can be set to perform a temperature calibration and measure a fixed number of reactions when it is determined that the temperature of the sample is below or equal to the preset temperature.

In operation S2210, the terminal uses a temperature gauge on the image of the biosensor to determine the temperature of the sample. Since a method of determining the temperature of a sample has been described above, details thereof are not provided herein.

In operation S2220, the terminal determines whether the temperature of the sample is lower than or equal to the preset temperature. Since the information about the sample can be pre-stored in the memory of the terminal, the range of appropriate temperatures of the sample can be determined. The terminal can determine whether the temperature of the sample is higher than the upper limit of the range of the appropriate temperature. When the terminal determines that the temperature of the sample is lower than or equal to the preset temperature, the terminal proceeds to operation S2230. Otherwise, the terminal proceeds to operation S2240.

In operation S2230, when it is determined that the temperature of the sample is not outside the upper limit of the range of the appropriate temperature, that is, when it is determined that the temperature of the sample is lower than or equal to the upper limit, the terminal passes the reference luminance information and the test line as described above. The brightness is compared to calibrate the quantitative value or temperature.

In operation S2240, when it is determined that the temperature of the sample is outside the upper limit of the range of the appropriate temperature, the terminal displays information that the temperature of the sample is outside the range of the appropriate temperature, and a message indicating that the measurement is not measurable or should be retested.

23 is a perspective view illustrating a biosensor including a plurality of reagent pads, according to an exemplary embodiment.

In the above, a reagent reaction is generated for one sample. However, as another alternative, various measurements can be obtained by simultaneously measuring a plurality of reagent reactions via one sample.

The urine diagnostic strip can be used to measure multiple reagent reactions, or can be used to briefly measure at least one of various diseases. By attaching the plurality of reagent pads for measuring the results of various reagent reactions to the urine diagnostic strip, the onset of various diseases can be roughly determined by inputting the urine sample at one time.

Table 1 below shows examples of a range of diseases that can be determined via reagent reactions of the samples. [Table 1]

Since different reagents are used for different diseases as shown in Table 1, the reagent pads can be discolored to different colors. Even when the reagent pads are discolored to the same color, the brightness of the colors can be different. The terminal may have information about the color change and brightness of the color in advance in the memory, and analyze the received image of the biosensor by comparing the discoloration and brightness of the received image with the discoloration and brightness in the normal positive reaction. The result of calibrating a fixed number of reactions.

An example of utilizing information about the discoloration of the reagent pad of the urine diagnostic strip and selectively utilizing information about the brightness to diagnose the disease will now be described.

Regarding the occult blood (hematuria) reagent reaction, when the user has hematuria, the reagent pad can change color to green. Here, the user's urine sample contains red blood cells, which means that the user may have kidney disease or bleeding in the urinary tract.

Regarding the bilirubin reagent reaction, liver or kidney dysfunction or bile discharge can be determined. When the reagent pad is discolored into red, the user's urine sample contains bilirubin, which means that the user's liver cells are damaged or the user may have biliary atresia.

Regarding the urobilinogen reagent reaction, when the urobilinogen is detected in the urine sample of the user due to liver or kidney dysfunction, the reagent pad is discolored to red.

Regarding the ketone body reagent reaction, when the user's urine sample contains many bubbles, the urine sample may contain many protein components. If the user is fatigued or starved, keto acid is produced in the user's body, thereby lowering the pH in the urine. Then, the amount of gas dissolved in the urine is increased, bubbles are generated, and thus the reagent pad is discolored to a deep purple color.

Regarding the protein reaction, when the reagent pad was discolored to dark green, it was confirmed that the protein discharge amount was increased due to renal dysfunction. Normally, less than 150 mg of protein is excreted daily through the urine. When more than 150 mg of protein is excreted daily through the urine, the user may have proteinuria. When the user's kidney is dysfunctional, the amount of protein in the urine may increase, and when the user has chronic conditions of chronic nephritis, renal disease, or diabetic acidemia, the amount of protein in the urine further increases, and further The reagent pad is discolored into a dark green color.

Regarding the nitrite (urinary tract bacterial infection) reagent reaction, it is judged whether the urine contains nitrite, and whether the bacteria in the urine can change the nitrate into nitrite. When the urine contains nitrite, the test line of the reagent pad changes color, indicating that the urinary tract is infected by bacteria.

Regarding the glucose reagent reaction, if the reagent pad is discolored into a dark brown color, the user is highly likely to have diabetes.

Regarding the pH (hydrogen ion concentration) reagent reaction, the pH of the urine has an acidic level of from 4.6 to 8 under normal conditions, and when the pH is increased (when the pH is increased), the reagent pad is discolored to green.

Regarding the specific gravity reagent reaction, the material dissolved in the urine was measured, and the normal range of specific gravity was from 1.016 to 1.022.

Regarding the white blood cell reagent reaction, when the white blood cell value is abnormal, the reagent pad is discolored to purple.

Information about discoloration and brightness may be pre-stored in the terminal or may be included in the biosensor's identification information. Information can be obtained from the server when such information cannot be obtained from the terminal or biosensor.

Therefore, the terminal can receive an image of the urine diagnostic strip for performing simultaneous reaction of various reagents on one sample, thereby determining various diseases.

FIG. 24 is a perspective view illustrating a biosensor including a plurality of reagent pads, according to another exemplary embodiment.

As described above with reference to FIG. 23, the terminal can measure various types of biological information using a biosensor, and perform various reagent reactions on the biosensor by inputting the sample once. As shown in Figure 24, the plurality of reagent pads or sensor arrays can be attached to a biosensor. A sample can be input to each of the plurality of reagent pads or can be input to a common sample inlet of the plurality of reagent pads. As described above, the temperature gauge can be attached to a reagent pad or biosensor to measure the temperature and/or room temperature of the sample.

FIG. 25 is a view illustrating a biosensor including a plurality of reagent pads and including identification information of a biosensor, according to an exemplary embodiment.

As shown in FIG. 25, identification information including information about the biosensor is displayed on the biosensor. The biosensor can be identified via identification information in the form of a text (for example, "12345-6789 Gildong Hong") or identification information in the form of a QR code or a bar code.

Further, information on the arrangement of the plurality of reagent pads can be used as identification information. As shown in Figure 24, the eight reagent pads attached to the biosensor can have different colors. The terminal can match the position of the reagent pads having different colors with the information about the arrangement of the plurality of reagent pads stored in the terminal in advance to determine the identification information.

The combination of identification information can be varied by changing the position of the reagent pad attached to the biosensor and the color of the reagent pad, and the terminal can use the reagent pad while receiving and reading the image of the biosensor. The location is used as identification information.

The terminal can use the shape of the biosensor as the identification information of the biosensor. For example, the ratio of the width to the length of the biosensor can be used as identification information. As another example, the shape of the biosensor (ie, the rectangular shape or the oval shape of the biosensor) can be used as the identification information. As yet another example, the color of the biosensor can be used as identification information.

The identification information displayed on the biosensor including the plurality of reagent pads can include information about the reagent response of each reagent pad. The identification information may include information about the discoloration of the reagent pad due to reagent reaction or information about the reagent response, for example, using reagent reactions to analyze diabetes or protein information.

Upon receiving an image of the biosensor including the plurality of reagent pads, the terminal can obtain information about the reaction of each reagent and determine the result of the reagent reaction based on the color and brightness of the reagent reaction. When the reagent pad is discolored as a positive reaction, a qualitative determination may be performed based on the discoloration to determine the presence of the disease, or the quantitative determination may be performed based on the brightness (darkness) of the discolored color.

FIG. 26 is a view illustrating a biosensor displaying reference brightness information around a reagent pad 2600, according to an exemplary embodiment.

The reference brightness information for each of the plurality of reagent pads can be displayed on the biosensor. The reagent pad can be discolored into different colors based on the reagent reaction, and the terminal can receive the brightness information of the color change color as an image and calibrate the quantitative value based on the brightness information to perform accurate measurement.

As shown in FIG. 26, reference brightness information including various types of reference brightness information 2601 to 2605 for the color-changing color of the reagent pad 2600 can be displayed. For example, when the reagent pad 2600 is discolored into blue due to the reagent reaction, the brightness level of the blue is the first level (the brightest level) of the five levels. The biosensor may display reference brightness information 2601 to 2605 having a first level to a fifth level of blue around the reagent pad 2600.

The terminal can receive information regarding the color and brightness of the reagent pad 2600 and reference brightness information 2601 to 2605. The terminal can obtain a relative difference in brightness of the reagent pad 2600 relative to the brightness in a fixed amount of reaction as a quantitative value. The terminal can calibrate the brightness of the reagent pad 2600 using the reference brightness information 2601 to 2605. When the illumination of the space in which the measurement is performed is illuminated, the brightness and reference brightness information 2601 to 2605 of the reagent pad 2600 are also measured to be brighter than when the illumination is dark.

Since the terminal pre-stores the brightness information of the reagent reaction in a fixed amount of reaction, the calibration can be performed using the brightness information in the fixed amount of reaction. For example, the brightness level of the area of the reference brightness information pre-stored in the terminal may be the second level, and the brightness level of the area of the reference brightness information in the image of the biosensor obtained by the terminal is the first level, wherein The zone corresponds to a fixed number of reactions. In addition, the first level can be brighter than the second level. In addition, the brightness level of the reagent pad from the image of the biosensor can be at the first level. The terminal can change the brightness level of the region in the image of the biosensor from the first brightness level to the second level, and can also change the brightness level of the reagent pad from the first level to the second level. Therefore, the terminal can calibrate the brightness level of the reagent pad using the brightness level in a pre-stored fixed number of reactions.

Since the calibrated brightness level of the reagent pad is at the second level (although the brightness level of the reagent pad in the image is the first level), the terminal can determine that the quantitative value corresponding to the reagent reaction is the same as the quantitative value corresponding to the fixed amount of reaction. . Therefore, the terminal can determine that the reaction result is a positive reaction. In addition, the terminal can indicate the presence of a disease or related value based on a positive reaction.

As another example, the brightness level in a fixed number of reactions may be a third level in five levels, and the information in which the brightness level in a fixed number of reactions may be a third level is pre-stored in the terminal.

In addition, the reagent pad on the image of the biosensor obtained by the terminal can be changed into red, the brightness level of the reagent pad can be the second level, and the brightness level of the area corresponding to the fixed amount of the reference brightness information can be Four levels.

Since the reagent pad on the image of the biosensor changes to red, the terminal can determine to obtain a positive reaction. In addition, since the brightness level in the fixed number of reactions is the third level, and the brightness level of the area of the reference brightness information is the fourth level, the terminal can determine that the measurement is performed in a dark environment. Therefore, the terminal can make the image brighter. Therefore, the brightness level of the area of the reference brightness information can be changed from the fourth level to the third level, and the brightness level of the reagent pad can be changed from the second level to the first level.

Using the changed brightness level of the reagent pad, the terminal can quantitatively measure the biological information. When the reagent pad is brighter, the corresponding value is lower, and when the reagent pad is darker, the value is higher. Since the brightness level of the reagent pad is the first level that is brighter than the brightness level (ie, the third level) in the fixed number of reactions, the terminal can determine that the value corresponding to the reagent reaction is lower than the value corresponding to the fixed amount of reaction. The terminal can display the detected value as biometric information.

According to another exemplary embodiment, the terminal may utilize the obtained image to calculate quantitative biometric information without calibrating the acquired image. For example, as shown in FIG. 26, the biosensor can include a reagent pad 2600 and reference brightness information 2601 to 2605 displayed around the reagent pad 2600. The terminal can calculate the quantitative biological information by using the image obtained by capturing the reagent pad 2600 and the reference brightness information 2601 to 2605.

At least two of the reference information 2601 to 2605 may be displayed around the reagent pad 2600. For example, as shown in FIG. 26, five pieces of reference information 2601 to 2605 can be displayed. Each of the displayed reference brightness information 2601 to 2605 may have different brightness from each other. Referring to FIG. 26, each of the five pieces of reference information 2601 to 2605 may have a brightness corresponding to one of five levels of brightness. The first reference brightness information 2601 may have a brightness corresponding to the first brightness level. The second reference brightness information 2602 may have a brightness corresponding to the second brightness level. The third reference brightness information 2603 may have a brightness corresponding to a third brightness level. The fourth reference brightness information 2604 can have a brightness corresponding to a fourth brightness level. The fifth reference brightness information 2605 can have a brightness corresponding to a fifth brightness level.

The color of reagent pad 2600 can vary due to reagent reaction. The reagent pad 2600 can be discolored to a blue color having various brightness levels depending on the reagent reaction. As shown in FIG. 26, the reagent pad 2600 can be discolored to a blue color corresponding to the first brightness level of the five brightness levels. The brightness of the reagent pad 2600 can be the same as the brightness of the first reference brightness information 2601.

The terminal can obtain an image by capturing the reagent pad 2600 and the reference brightness information 2601 to 2605. The brightness of the image can vary depending on the environment in which the image was shot. For example, if an image is taken in an environment that provides sufficient illumination, the image may be brighter than an image taken in an environment that does not provide sufficient illumination. Thus, even if the reagent pad 2600 has an actual brightness corresponding to the first brightness level, the brightness of the reagent pad 2600 appearing in the obtained image may vary depending on the environment.

The reference brightness information 2601 to 2605 can exhibit the same effect on the illumination used by the reagent pad 2600. The reagent pad 2600 can exhibit the same effect on the illumination used by the first reference brightness information 2601, wherein the first reference brightness information 2601 has the same brightness as that of the reagent pad 2600. Therefore, the brightness of the reagent pad 2600 appearing in the obtained image can be the same as the brightness of the first reference brightness information 2601 appearing in the image. In other words, if there is a reference brightness information 2601 to 2605 whose brightness is the same as the brightness of the reagent pad 2600, the brightness of the reagent pad 2600 appearing in the image may be the same as the one piece of reference brightness information 2601 appearing in the image. The brightness of 2605. In addition, if there is a reference brightness information 2601 to 2605 whose brightness is different from the brightness of the reagent pad 2600, the brightness of the reagent pad 2600 appearing in the image may be different from the brightness of the piece of brightness information 2601 to 2605 appearing in the image. .

Therefore, the terminal can compare the brightness of the reagent pad 2600 appearing in the image with the brightness of the reference brightness information 2601 to 2605 appearing in the image without any calibration of the image. As a result of the comparison, the terminal can detect a reference brightness information from the reference brightness information 2601 to 2605, wherein the one piece of reference brightness information has the same brightness as that of the reagent pad 2600. Referring to FIG. 26, the detected reference brightness information may be the first reference brightness information 2601.

The terminal can utilize the detected results to obtain the actual brightness of the reagent pad 2600. Referring to FIG. 26, the terminal can obtain information that the actual brightness of the reagent pad 2600 corresponds to the first brightness level. Therefore, the terminal can use the information included in the image to obtain the actual brightness of the reagent pad 2600 regardless of the environment in which the image is captured.

The terminal can utilize the actual brightness of the obtained reagent pad 2600 to calculate quantitative biological information corresponding to the reagent reaction. For example, when the reagent pad 2600 is brighter, the corresponding value can be lower, and when the reagent pad 2600 is darker, the corresponding value can be higher. Further, the brightness corresponding to a fixed amount of reaction may be the third brightness level. Referring to Fig. 26, the terminal can determine that the value corresponding to the reagent reaction is lower than the value corresponding to the fixed amount of reaction, because the actual brightness of the reagent pad 2600 is proven to be the first brightness level. The terminal can display the detected value as biometric information.

27 to 31 are reference diagrams for explaining a process of detecting the actual brightness of a reagent pad. Referring to FIG. 31, the biosensor may include a reagent pad 2600 and five pieces of reference information 2601 to 2605 displayed around the reagent pad 2600. The terminal can obtain an image by photographing a biosensor.

The terminal can process the obtained image. The terminal can process the image using the brightness information of the pixels contained in the image. The terminal can detect a region comprising pixels having the same brightness as the brightness corresponding to a portion of the reagent pad 2600 in the image.

The terminal can recognize the shape of the detected area. Although the brightness of the reagent pad 2600 may vary depending on the reagent reaction, the brightness of the reference brightness information 2601 to 2605 may be constant regardless of the reagent reaction. Therefore, the shape of the detected region can vary depending on the reagent reaction.

For example, the actual brightness of the reagent pad 2600 can be at a first brightness level based on the reagent reaction. The terminal can obtain the image shown on the left side of FIG. 27 by photographing the biosensor. The terminal can detect the shape shown on the right side of FIG. 27 by processing the obtained image.

As another example, the actual brightness of the reagent pad 2600 can be at a second brightness level depending on the reagent reaction. The terminal can obtain the image shown on the left side of FIG. 28 by photographing the biosensor. The terminal can detect the shape shown on the right side of FIG. 28 by processing the obtained image.

As yet another example, the actual brightness of the reagent pad 2600 can be at a third brightness level depending on the reagent reaction. The terminal can obtain the image shown on the left side of FIG. 29 by photographing the biosensor. The terminal can detect the shape shown on the right side of FIG. 29 by processing the obtained image.

As a further example, the actual brightness of the reagent pad 2600 can be at a fourth brightness level based on the reagent reaction. The terminal can obtain the image shown on the left side of FIG. 30 by photographing the biosensor. The terminal can detect the shape shown on the right side of FIG. 30 by processing the obtained image.

As yet another example, the actual brightness of the reagent pad 2600 can be at a fifth brightness level depending on the reagent reaction. The terminal can obtain the image shown on the left side of FIG. 31 by photographing the biosensor. The terminal can detect the shape shown on the right side of FIG. 31 by processing the obtained image.

The terminal can detect the actual brightness of the reagent pad 2600 based on the identified shape of the detected area. For example, when the shape shown on the right side of FIG. 27 is recognized, the terminal can determine that the actual brightness of the reagent pad 2600 is the first brightness level. When the shape shown on the right side of FIG. 28 is recognized, the terminal can determine that the actual brightness of the reagent pad 2600 is the second brightness level. When the shape shown on the right side of FIG. 29 is recognized, the terminal can determine that the actual brightness of the reagent pad 2600 is the third brightness level. When the shape shown on the right side of FIG. 30 is recognized, the terminal can determine that the actual brightness of the reagent pad 2600 is the fourth brightness level. When the shape shown on the right side of FIG. 31 is recognized, the terminal can determine that the actual brightness of the reagent pad 2600 is the fifth brightness level.

Figure 32 is another view illustrating the biosensor displaying reference brightness information around the reagent pad. Referring to FIG. 32, the reference luminance information 2606 can be continuously displayed, while the reference luminance information 2601 to 2605 is discretely displayed on FIG. For example, as shown in FIG. 32, the reference brightness information 2606 can be continuously displayed in the upward direction from the first brightness level to the fifth brightness level. In other words, the reference luminance information 2606 can be continuously displayed in the upward direction from the luminance corresponding to the maximum response to the luminance corresponding to the minimum response or non-reaction. For example, reference brightness information 2606 can be continuously displayed from brightness corresponding to a reaction rate of 0% to brightness corresponding to a reaction rate of 100%, wherein a reaction rate of 0% corresponds to a minimum response or no reaction, and 100% The reaction rate corresponds to the maximum reaction.

The terminal can obtain an image by capturing the reagent pad 2600 and the reference brightness information 2606. The terminal can compare the brightness of a portion of the reagent pad 2600 corresponding to the image with a portion corresponding to the reference brightness information 2606. The terminal can detect a position of a portion of the same brightness as the brightness of the reagent pad 2600 in the reference brightness information 2606. For example, the actual brightness of the reagent pad 2600 can be a third brightness level. The terminal can determine that a portion having the same brightness as the brightness of the reagent pad 2600 is located in the middle of the reference brightness information 2606.

As another example, the actual reaction rate of the reagent reaction can be 56%, with a reaction rate of 0% corresponding to the minimum reaction or no reaction, and a reaction rate of 100% corresponding to the maximum reaction. The terminal can determine that a portion of the same brightness as the brightness of the reagent pad 2600 is located at 56% of the full length of the reference brightness information 2606. The terminal can determine the actual reaction rate of the reagent reaction based on the detected position to be 56%.

The terminal can detect the actual brightness of the reagent pad 2600 based on the detected position. For example, when it is determined that a portion having the same brightness as the brightness of the reagent pad 2600 is located in the middle of the reference brightness information 2606, the terminal may determine that the actual brightness of the reagent pad 2600 is the third brightness level. As another example, when it is determined that a portion having the same brightness as the brightness of the reagent pad 2600 is located at 56% of the total length of the reference brightness information 2606, the terminal may determine that the actual brightness of the reagent pad 2600 corresponds to a reaction rate of 56%. .

FIG. 33 (including portions (a), (b), (c), and (d) of FIG. 33 is a diagram for explaining the entire operation of executing the sample measurement program by the terminal according to an exemplary embodiment.

Referring to part (a) of Fig. 33, the user of the terminal can input its sample to the biosensor.

Referring to part (b) of FIG. 33, the user can use the input interface (camera) of the terminal to obtain an image of the biosensor.

Referring to part (c) of FIG. 33, the terminal can analyze the image and derive a relative difference in brightness of the reagent pad from the fixed amount of reaction as a quantitative value based on whether the reagent pad is discolored, the brightness of the reagent pad, and the reference brightness information.

Referring to part (d) of FIG. 33, the terminal displays the detected biological information to provide the detected biological information to the user.

FIG. 34 is a diagram illustrating a biosensor displaying reference color information, according to an exemplary embodiment.

When the biosensor includes a plurality of reagent pads, the reagent pads may be discolored to different colors, but it may be difficult to divide the discolored color. Therefore, the reference color information A to F is displayed on the biosensor as the reference color display area to obtain accurate discoloration information.

The color of the reagent pad obtained when the reagent pad is positive can be displayed on the biosensor as a reference color. For example, when the ketone reagent reacts positively, the reagent pad can change to a deep purple color. Therefore, dark purple can be displayed on the biosensor as reference color information to support accurate measurement of biological information.

FIG. 35 is a diagram for explaining a method of analyzing biometric information using exhaled breath, according to an exemplary embodiment.

As described above, the sample including the biological information may be urine, sweat, tears, saliva or blood, and may be, for example, a gas such as exhaled breath.

As shown in Figure 35, the user can exhale to a biosensor capable of measuring exhaled breath. Here, the biosensor may be an electronic component such as a breath analyzer, or may be an inflation tube containing a dye.

The biosensor can contain a dye and can measure biometric information as the dye reacts with the exhaled breath and the color of the dye changes. Such a biosensing technique is called a colorimetric sensor array technique, and a color change pattern can be determined by arranging a plurality of dyes that change color on a 2-dimensional (2D) plane. .

FIG. 36 is a diagram illustrating an example of measuring a breath gas by a biosensor according to an exemplary embodiment.

As shown in Fig. 36, a tube containing a certain amount of gas can be used as an element for measuring exhaled breath. In the tube, a plurality of dyes are arranged on a 2-dimensional plane, and the biometric information can be measured using the result of discoloration of the plurality of dyes according to the reaction with the exhaled breath.

The plurality of dyes can be used to diagnose different diseases. For example, the dye on the reagent pad (a) can be used to diagnose asthma, the dye on the reagent pad (b) can be used to diagnose bad breath, and the dye on the reagent pad (c) can be used to diagnose chronic obstructive lung disease. The plurality of reagent pads may each comprise a plurality of dyes to separately diagnose a plurality of diseases, or a combination of the plurality of reagent pads may be used to diagnose a disease.

For example, cancer can be diagnosed via exhaled breath. Metabolic material of cancer cells can be dissolved in the blood and can be excreted outward through exhaled breath. The material discharged through the exhaled breath can react with a plurality of dyes arranged on the tube, and the metabolic material of the cancer cells can be detected based on whether the color of the dye changes.

As shown in Fig. 36, with reference to the reagent pad (a) to the reagent pad (h), a plurality of dyes are arranged in a 2-dimensional direction on a tube (i.e., a biosensor) in which the dye has an essential color. After discoloring the dye by reacting with the material in the exhaled breath, the user can use the optical image sensor (camera) of the terminal to take an image of the tube.

The plurality of dyes contained in the reagent pad can be distinguished from one another by their color and brightness. For example, the dyes contained in the reagent pad (b) can be distinguished into three groups of red dyes, yellow dyes, and blue dyes, each of which has a different brightness.

The terminal can obtain an image of the tube and can also obtain color information, reference brightness information, and identification information of the reagent pad from the obtained image. The reference brightness information can be displayed around the dye or at a location separate from the reagent pad. Since the reference luminance information has been explained above with reference to FIGS. 10 to 13, the details thereof are not provided here.

The terminal can determine the brightness of the reagent pad containing the dye and can pre-store the brightness information in the fixed amount of reaction between the dye and the material in the exhaled breath in the reservoir. Therefore, the terminal can derive a quantitative value corresponding to the reagent reaction by referring to a reagent pad in which the color and brightness have a high similarity to the reagent from the received image. The terminal can obtain a quantitative value corresponding to the reagent reaction by searching an internal database or an external database to obtain information about the brightness information of the dye and the reference brightness information that is the same as or similar to the brightness information of the dye.

The biosensor for analyzing the exhaled breath may include a plurality of reagent pads each including a plurality of dyes in a two-dimensional direction, wherein the arrangement information of the reagent pads may be used as identification information of the biosensor. The dye has an essential color and the pattern of colors can be stored in a database for use as identification information for the user or biosensor. For example, when the biosensor includes eight reagent pads, the positions of the reagent pads can be combined to show one pattern. The terminal may obtain information about the user who is using the biosensor or identification information of the biosensor based on the pattern on the image of the biosensor.

FIG. 37 is a diagram illustrating a medical system that provides a measurement service to a sample measurement terminal, according to an exemplary embodiment.

The quantitative value calibration and the biometric information measurement performed by the reagent reaction described above with reference to FIGS. 1 to 28 can be configured as a manufacturer of the terminal (for example, Samsung Electronics), a medical service provider, and a user of the terminal. Medical services between (for example, service users).

The manufacturer of the terminal can manufacture a terminal capable of measuring biological information from the biosensor via an optical image sensor. In addition, manufacturers can manufacture biosensors that are capable of performing point-of-care diagnostics (POCT).

The service provider can be an institution that uses biometric information, such as a medical institution (eg, a hospital or pharmacy) or an insurance company. The service provider has a network system (such as a server) to communicate with the terminal and can store a database of various types of information, such as the results of reagent reactions. Service providers can also create biosensors that perform immediate diagnostics.

The user of the terminal receives the medical service and can collect samples (such as urine or blood) to measure the biological information using an application installed in the terminal (for example, S Health). Users can sign contracts (subscription contracts) with offline or online service providers. For example, the user can be a patient and the service provider can be the hospital where the user lives. If the user is not convenient to go to the hospital or must measure the biological information, the user can use the terminal to measure the biological information. Thus, the hospital (ie, the service provider) can provide the user with a biosensor capable of performing an immediate diagnosis. As another example, the user may be an individual who wants to obtain an insurance policy, and the service provider may be an insurance company. Since the user can measure and transmit his or her biological information to apply to the insurance company, the service provider can provide the user with a biosensor capable of performing an immediate diagnosis.

The user can use the application installed in the terminal to measure the biological information and transmit the biological information to the service provider, and the service provider can store the user's biological information. Service providers and terminals can store user biometric information to share information about the treatment of various diseases.

The service provider can provide medical services to the user periodically or non-periodically to manage the user's health conditions. The user can be provided with a service that instantly manages the user's health conditions and the biometric information measured by the wearable component (eg, a smart watch or smart glasses).

FIG. 38 is a view illustrating a screen of a terminal 100 in which a sample measurement program is executed, according to an exemplary embodiment.

A user of the terminal 100 can input his urine sample to the sample inlet of the biosensor and use the terminal 100 to obtain an image of the biosensor including the result of the reagent reaction.

The terminal 100 can analyze the image to perform quantitative measurement and qualitative measurement based on the color change result, color and brightness of the reagent reaction, and reference brightness information.

The display of terminal 100 includes display areas 142 and 144. Display area 142 may display information about the urine sample being analyzed in the text (eg, "analyzing urine") or image.

Display area 144 can display biometric information obtained by analyzing urine samples and can receive input from a user. For example, the terminal 100 can display the normal range and measurement values of the protein as a result of analyzing the urine sample, and the user can touch the protein button to manipulate the terminal 100 to display brief information about the diagnosis of the protein. Alternatively, when the protein button is touched, another biometric information can be displayed.

The terminal 100 may display a button for transmitting biometric information to an external component and a button for re-measuring biometric information when the biometric information is abnormal. When the temperature of the urine sample is outside the range of the appropriate temperature, when the expiration date of the biosensor has been exceeded, or when the value of the biometric information is outside the normal range, the biometric information can be determined to be abnormal. .

With respect to the medical system described above with reference to FIG. 37, terminal 100 can provide a screen that enables a user to communicate with a physician (ie, a service provider) via remote video communication. When the terminal 100 stores information on the value of the biometric information, the stored information can be provided to the user. For example, when the terminal 100 stores information about the recommended food and the contraindicated food for diabetes and the value of the biological information indicates that the user has diabetes, the terminal 100 may display information about the recommended food and the contraindicated food.

Figure 39 is a network diagram illustrating a network environment for operation of the terminal. Referring to FIG. 39, the terminal 100 can be connected to the server 300 via a communication network. The terminal 100 can obtain an image by photographing the biosensor 200. The terminal 100 can transmit the obtained image to the server 300. The terminal 100 can receive an analysis result regarding the image from the server 300. The terminal 100 can display the received analysis result. A more detailed description of the operation of the terminal 100 and the server 300 will be explained below with reference to FIG.

40 is a flow chart of a process for displaying biometric information using an image of a biosensor. Referring to FIG. 40, in operation S100, an image of a biosensor including a reagent pad on which a sample is collected may be photographed. The terminal 100 can capture an image of the biosensor 200 by a camera included in the terminal 100. The terminal 100 can obtain an image by capturing the reagent pad 2600 and the reference brightness information 2601 to 2605 included in the biosensor 200.

The captured image may be transmitted to the server 300 in operation S110. The terminal 100 can transmit the obtained image to the server. The server 300 can receive images. The server 300 can process and analyze images. The server 300 can detect information about the color and brightness of a portion of the reagent pad 2600 in the image. In addition, the server 300 can detect information about colors and brightness corresponding to a portion of the reference brightness information 2601 to 2605. The detector 300 can compare information about the portion corresponding to the reagent pad 2600 with information corresponding to the portion of the reference brightness information 2601 to 2605. The server 300 can use the results of the comparison to calculate quantitative biometric information corresponding to the reagent response.

In operation S120, biometric information corresponding to the image may be received from the server 300. The terminal 100 can receive the analysis result of the image from the server 300. The terminal 100 receives the quantitative biological information corresponding to the reagent reaction from the server 300 as an analysis result.

In operation S130, the received biometric information may be displayed. The terminal 100 can display the received analysis result. The terminal 100 can utilize the display of the terminal 100 to display quantitative biological information included in the analysis result. FIG. 41 is a screen showing analysis results displayed on the terminal 100.

FIG. 42 is a block diagram showing the structure of the terminal 100, according to an exemplary embodiment.

The terminal 100 according to an exemplary embodiment includes an input interface 110 that receives material from an external source, a controller 120 that processes the material, and a storage 130 that stores input or processed data. The terminal 100 further includes a display 140 for displaying material on the screen of the terminal 100 and a communication interface 150 for communicating with another component. According to an exemplary embodiment, the terminal 100 may be a smart phone including an operating system (OS), and accesses the Internet or executes various programs. A smart phone can be a digital mobile component that is equipped with an operating system and communication functions to facilitate various content types for use in a user environment (UI/UX). According to an exemplary embodiment, the terminal 100 may be a multimedia player or a personal computer (PC).

The input interface 110 is an interface for receiving data (eg, content) displayed on the display 140, and may include at least one of: a universal serial bus (USB), parallel advanced technology (parallel advanced) Technology attachment, PATA), serial advanced technology attachment (SATA), flash media, Ethernet, Wi-Fi, and Bluetooth. The terminal 100 may include an information storage component (such as a CD drive or a hard disk) and receive the data via the information storage component, as needed.

Further, the terminal 100 according to an exemplary embodiment may include a camera including an optical image sensor as an input interface 110. Images received via the camera module can be processed into a single piece of material.

In addition to the camera, the input interface 110 may further include a sensor for measuring temperature or humidity. Here, the input interface 110 may include not only a temperature sensor that measures the internal temperature of the terminal 100 but also a temperature sensor that measures the external temperature of the terminal 100. Further, according to an exemplary embodiment, the humidity sensor that measures the humidity may also correspond to the input interface 110.

The input interface 110 can be a touch screen in which the touch panel and the image panel form a layer structure. The touch panel may be a capacitive type touch panel, a resistive film type touch panel, or an infrared type touch panel. The image panel can be a liquid crystal panel or an organic light emitting panel. Since the touch panel is a well-known technique, details are not provided herein. The image panel displays graphics for the user interface.

The controller 120 encodes or decodes the data input to the input interface 110.

The controller 120 provides a user interface based on the operating system of the terminal 100. The user interface reflects the user's use.

The storage 130 can store data that is input to or processed by the terminal 100. According to an exemplary embodiment, since the biometric information is determined by analyzing the image of the biosensor, the storage 130 may store various types of information related to the measurement of the biometric information (eg, information about various reagent reactions, biological The identification information of the sensor and the reference brightness information of the reagent pad are used as a database.

Display 140 can display data processed by terminal 100 in a user interface environment. According to an exemplary embodiment, since the image of the biosensor has been obtained and analyzed, the display 140 may display an image of the biosensor obtained by the camera, and may display the result of analyzing the reagent reaction as shown in FIG. Additionally, display 140 can display information to guide the user to input at least one of various manipulation commands.

The communication interface 150 can transmit data and control commands to another component and receive data and control commands from another component. The communication interface 150 can utilize well-known communication modules, such as an infrared communication module, a radio communication module, or an optical communication module. For example, the communication interface 150 can utilize an infrared communication module that satisfies the infrared data association (IrDA) protocol. As another example, a communication module using a 2.4 megahertz frequency or a communication module using Bluetooth can be used as the communication interface 150.

The communication interface 150 according to an exemplary embodiment may request a server of a service provider (eg, a hospital, a pharmacy, or an insurance company) to obtain data and receive data transmitted from the server.

Although not limited thereto, the exemplary embodiments may be embodied as computer readable codes on a computer readable recording medium. For example, the control program that controls the above operations can be implemented as a computer readable code on a computer readable recording medium. A computer readable recording medium is any data storage component that can store data that can be subsequently read by a computer system. Examples of computer readable recording media include read-only memory (ROM), random-access memory (RAM), compact disk-reading memory (compact disc-ROM, CD-ROM) ), tape, floppy disk, and optical data storage components. The computer readable recording medium can also be distributed over a network coupled computer system to store and distribute the computer readable code in a distributed manner. Moreover, the exemplary embodiments can be written as a computer program transmitted on a computer readable transmission medium (e.g., carrier wave) and received and implemented in a general purpose or special purpose digital computer executing the program. In addition, it should be understood that in an exemplary embodiment, one or more units can include circuitry, a processor, a microprocessor, etc., and can execute a computer program stored on a computer readable medium.

The foregoing exemplary embodiments and advantages are examples and should not be considered as limiting. The teachings of the present invention can be readily applied to other device types. In addition, the description of the exemplary embodiments is intended to be illustrative, and not restrictive,

100‧‧‧ Terminal
110‧‧‧Input interface
112‧‧‧ Non-contact temperature sensor
120‧‧‧ Controller
130‧‧‧Storage
140‧‧‧ display
142‧‧‧ display area
144‧‧‧ display area
150‧‧‧Communication interface
200‧‧‧Biosensor
210‧‧‧ sample entrance
215‧‧‧temperature measuring device
220‧‧‧Control line
230‧‧‧Test line
240‧‧‧Reference brightness information display area
250‧‧‧Recognition information display area
300‧‧‧Server
400‧‧‧ sample
525‧‧‧temperature measuring device
615‧‧‧temperature measuring device
625‧‧‧temperature measuring device
635‧‧‧temperature measuring device
810‧‧‧temperature sensor
1140‧‧‧Reference brightness information
2600‧‧‧Reagent pad
2601‧‧‧Reference brightness information
2602‧‧‧Reference brightness information
2603‧‧‧Reference brightness information
2604‧‧‧Reference brightness information
2605‧‧‧Reference brightness information
2606‧‧‧Reference brightness information
A, B, C, D, E, F‧‧‧ reference color information
ISL‧‧‧ internal standard line
S100, S110, S120, S130, S1310, S1320, S1330, S1340, S2110, S2120, S2130, S2140, S2210, S2220, S2230, S2240‧‧
TL‧‧‧ test line

The above and/or other aspects will become more apparent from the following description of the exemplary embodiments in the accompanying drawings in which: FIG. 1 is a perspective view illustrating a terminal and a biosensor according to an exemplary embodiment. 2 is a view illustrating a reagent pad to which a temperature measuring device is attached, according to an exemplary embodiment. 3 (including portions (a) and (b) of FIG. 3) is a diagram illustrating various positions of a temperature gauge according to an exemplary embodiment. 4 is a cross-sectional view of a sample inlet of a reagent pad, in accordance with an exemplary embodiment. FIG. 5 is a view of a temperature gauge attached to a reaction zone of a reagent pad, in accordance with an exemplary embodiment. FIG. 6 is a view of a biosensor to which a temperature measuring device for measuring a room temperature is attached, according to an exemplary embodiment. Figure 7 (comprising parts (a), (b) and (c) of Figure 7) is a diagram illustrating various types of temperature gauges in accordance with an exemplary embodiment. FIG. 8 (including portions (a) and (b) of FIG. 8) is a diagram illustrating a temperature gauge of a terminal according to an exemplary embodiment. Figure 9 (including parts (a), (b), (c), (d) and (e) of Figure 9) illustrates various elements for measuring the temperature and room temperature of a sample according to an exemplary embodiment. Figure. FIG. 10 is a diagram for explaining a terminal that photographs an image of a biosensor, according to an exemplary embodiment. FIG. 11 is a view illustrating a biosensor displaying reference luminance information, according to an exemplary embodiment. 12 (including portions (a), (b), and (c) of FIG. 12) is a diagram illustrating reference luminance information that varies according to colors according to an exemplary embodiment. FIG. 13 is a flowchart of a method for measuring biometric information by an image of a biosensor by a terminal, according to an exemplary embodiment. FIG. 14 is a graph illustrating a change in luminance value according to a temperature of a sample, according to an exemplary embodiment. 15 (including portions (a), (b), and (c) of FIG. 15) is a diagram illustrating an identification display indicating identification (ID) information of a biosensor according to an exemplary embodiment. FIG. 16 is a diagram for explaining a reaction of a reagent pad with a sample according to an exemplary embodiment. 17 is a graph showing changes in obtained product obtained when a reagent pad is reacted with a sample, as a function of temperature, according to an exemplary embodiment. FIG. 18 is a graph showing temperature of a sample and a calibrated temperature, according to an exemplary embodiment. 19 and 20 are graphs of the degree of reaction as a function of temperature during a reaction, in accordance with an exemplary embodiment. 21 and 22 are flowcharts of a method of determining whether the temperature of a sample is within a range of an appropriate temperature, according to an exemplary embodiment. 23 is a perspective view illustrating a biosensor including a plurality of reagent pads, according to an exemplary embodiment. FIG. 24 is a perspective view illustrating a biosensor including a plurality of reagent pads, according to another exemplary embodiment. FIG. 25 is a view illustrating a biosensor including a plurality of reagent pads and including identification information of a biosensor, according to an exemplary embodiment. FIG. 26 is a view illustrating a biosensor displaying reference brightness information around a reagent pad, according to an exemplary embodiment. FIG. 27 is a reference diagram for explaining a process of detecting an actual brightness of a reagent pad, according to an exemplary embodiment. 28 is another reference diagram for explaining a process of detecting an actual brightness of a reagent pad, according to an exemplary embodiment. 29 is a further reference diagram for explaining a process of detecting an actual brightness of a reagent pad, according to an exemplary embodiment. FIG. 30 is still another reference diagram for explaining a process of detecting an actual brightness of a reagent pad according to an exemplary embodiment. FIG. 31 is still another reference diagram for explaining a process of detecting an actual brightness of a reagent pad according to an exemplary embodiment. 32 is another view illustrating a biosensor displaying reference brightness information around a reagent pad, according to an exemplary embodiment. Fig. 33 (including portions (a), (b), (c), and (d) of Fig. 33 is a diagram for explaining an entire operation of executing a sample measurement program by a terminal according to an exemplary embodiment. FIG. 34 is a diagram illustrating a biosensor displaying reference color information, according to an exemplary embodiment. FIG. 35 is a diagram for explaining a method of analyzing biometric information using exhaled breath, according to an exemplary embodiment. FIG. 36 is a diagram illustrating an example of measuring a breath gas by a biosensor according to an exemplary embodiment. FIG. 37 is a diagram illustrating a medical system providing a measurement service to a sample measurement terminal, according to an exemplary embodiment. FIG. 38 is a view illustrating a screen of a terminal in which a sample measurement program is executed, according to an exemplary embodiment. FIG. 39 is a network diagram illustrating a network environment for a terminal to operate, according to an exemplary embodiment. FIG. 40 is a flowchart of a process of displaying biometric information using an image of a biosensor, according to an exemplary embodiment. FIG. 41 is a screen illustrating an analysis result displayed on a terminal, according to an exemplary embodiment. FIG. 42 is a block diagram showing the structure of a terminal, according to an exemplary embodiment.

Claims (12)

A method for measuring biometric information by a terminal, the method comprising: receiving an image of a biosensor, the biosensor comprising a reaction zone and reference brightness information, the reaction zone having a reagent reactive with the sample; Comparing brightness information of the reaction zone in the received image with the reference brightness information in the received image to determine a result of the reaction, wherein determining the result of the reaction comprises: from the reference The brightness information detects first brightness information, the first brightness information corresponds to the brightness information of the reaction area; and determines a result of the reaction based on the first brightness information. The method for measuring biometric information by a terminal according to claim 1, wherein determining the result of the reaction comprises: determining the brightness information of the reaction zone in the received image and the receiving The reference brightness information in the image; comparing the brightness information of the reaction area in the received image with the reference brightness information in the received image to determine a value of the reaction zone; And determining a result of the reaction based on the determined value. The method for measuring biometric information by a terminal according to claim 1, further comprising: identifying the biosensing based on identification information displayed on the biosensor in the received image. And; A result of the reaction is determined based on information of the identified biosensor. The method for measuring biometric information by a terminal according to claim 1, wherein determining the result of the reaction comprises: obtaining temperature information of the reaction zone from the received image, wherein the temperature information is Indicated by a temperature gauge in the biosensor. The method of measuring biometric information by a terminal according to claim 4, wherein determining the result of the reaction comprises determining a result of the reaction based on the obtained temperature information. The method of measuring biometric information by a terminal according to claim 4, wherein the temperature measuring device is configured to be attached to a sample inlet of the reagent pad and the reaction zone of the reagent pad At least one of them. The method for measuring biometric information by a terminal according to claim 2, wherein the reference luminance information indicates different discrete luminances for the same color, and wherein the comparing the luminance information of the reaction region The method includes: detecting the first brightness information in the reference brightness information, the first brightness information corresponding to the brightness information of the reaction area; and determining the reaction corresponding to the first brightness information The stated value. A method for measuring biometric information by a terminal according to claim 2, wherein the reference luminance information indicates different continuous luminances for the same color, wherein the different continuous luminances are continuously placed in the reference Brightness information The comparing the brightness information of the reaction area includes: detecting the first brightness information in the reference brightness information, where the first brightness information corresponds to the brightness information of the reaction area; Detecting a location of the first luminance information in the reference luminance information; and determining the value of the response corresponding to the detected location. The method for measuring biometric information by a terminal according to claim 2, wherein the reference luminance information indicates different discrete luminances for the same color, and wherein comparing the luminance information of the reaction region comprises: Detecting, in the image, a region including a pixel having the same brightness as a brightness corresponding to a portion of the reaction region; identifying a shape of the detected region; determining the reaction based on the recognized shape The actual brightness of the zone; and determining the value of the reaction corresponding to the determined actual brightness. The method for measuring biometric information by a terminal according to claim 1, wherein the biosensor includes a reagent pad to support a reaction between the reagent pad and the sample, and the method Further comprising: identifying the biosensor based on a location of the reagent pad in the received image. A terminal for measuring information of a living body, the terminal comprising: An input interface for receiving an image of a biosensor, the biosensor comprising a reaction zone and reference brightness information, the reaction zone having a reagent reactive with the sample, and a reservoir for storing the received image; And a controller for comparing brightness information of the reaction zone in the received image with reference brightness information in the received image to determine a result of the reaction, wherein the controller is configured to The reference brightness information detects first brightness information, the first brightness information corresponds to the brightness information of the reaction area; and determines a result of the reaction based on the first brightness information. A method for measuring biometric information by a terminal, the method comprising: capturing an image of a biosensor, the biosensor comprising a reaction zone and reference brightness information, the reaction zone having a reagent reactive with the sample; Transmitting the image to the server; receiving the biological information from the server, wherein the biological information is obtained by using brightness information of the reaction area in the image and reference brightness information in the image Determining a comparison; and displaying the received biometric information, wherein determining the biometric information is determined by detecting the first luminance information from the reference luminance information and determining a response based on the first luminance information The first brightness information corresponds to the brightness information of the reaction zone.