TWI696460B - Container for a consumable good, coated with a resveratrol-containing layer, process for preparing the container, use of the container for the storage of a consumable good, and use of resveratrol as an additive to a coating layer of the container - Google Patents
Container for a consumable good, coated with a resveratrol-containing layer, process for preparing the container, use of the container for the storage of a consumable good, and use of resveratrol as an additive to a coating layer of the container Download PDFInfo
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Abstract
Description
本發明係關於一種包含一含白藜蘆醇之塗層的容器,具體而言,其朝向該容器的內部。具體而言,該容器應填充有消費性商品,具體而言為食物或食品、個人護理或醫藥產品。其具體而言具有一含白藜蘆醇的內塗層。本發明進一步涉及製備此一容器的方法、使用所述容器以儲存消費性商品的應用及使用白藜蘆醇作為添加劑添加至這種容器的塗層的應用。 The present invention relates to a container containing a resveratrol-containing coating, in particular, it faces the inside of the container. Specifically, the container should be filled with consumer goods, specifically food or food, personal care or medical products. Specifically, it has an inner coating containing resveratrol. The invention further relates to a method of preparing such a container, the use of the container to store consumer goods and the use of resveratrol as an additive added to the coating of such a container.
數個世紀以來,消費性商品已被儲存於各種容器中,包括木材、獸皮、陶器以及皮革。 For centuries, consumer goods have been stored in various containers, including wood, animal skins, pottery, and leather.
在過去十年中,替代的包裝形式,例如金屬容器、塑膠容器如以聚乙烯(polyethylene,PE)、聚丙烯(polypropylene,PP)、聚對苯二甲酸乙二酯(polyethylenetetraphthate,PET)或其他聚合物及其混合物所製成者, 以及紙或紙板容器的普及性增加。其提供了較少重量的優點,然而其特性在很多情況下,特別是是對氧化作用敏感的商品而言,並不適合長期儲存。 In the past decade, alternative packaging forms, such as metal containers, plastic containers such as polyethylene (PE), polypropylene (PP), polyethylene tetraphthate (PET) or other Made of polymers and their mixtures, And the popularity of paper or cardboard containers has increased. It offers the advantage of less weight, but its characteristics are not suitable for long-term storage in many cases, especially for products sensitive to oxidation.
這種對氧化作用敏感的商品與所有領域的消費性商品(消耗品)相關,特別是食品,例如食物與飲料,但也包括醫藥產品或藥物、醫療與獸醫製品及化妝品及個人護理產品。在許多情況下,也因這些商品或產品的相對積極的特性而產生問題。這些問題在液體與固體消費性商品中皆出現。產品與容器或進入該容器的化合物(例如氧氣)交互作用的結果是,該產品品質受損及/或該消費性商品的使用期限與儲存穩定性之減損。 Such products sensitive to oxidation are related to consumer goods (consumables) in all fields, especially foods such as food and beverages, but also include medical products or medicines, medical and veterinary products, cosmetics and personal care products. In many cases, problems also arise due to the relatively positive nature of these commodities or products. These problems occur in both liquid and solid consumer goods. As a result of the interaction of the product with the container or the compound (such as oxygen) entering the container, the quality of the product is impaired and/or the life span and storage stability of the consumer goods are compromised.
為了確保產品完整性、使用壽命以及符合消費者對可持續包裝的要求,以及在各種全球儲存與運輸條件之下維持該商品品質的需求,一個強大包裝系統的開發,特別是針對精緻產品(消費性商品)而言,被認為是需要的。 In order to ensure product integrity, service life, and meet consumer requirements for sustainable packaging, as well as to maintain the quality of the commodity under various global storage and transportation conditions, the development of a powerful packaging system, especially for delicate products (consumption Sex goods) is considered necessary.
隨著全球化以及全球市場對消費性商品的需求增加,需要在全球性運輸這些商品的同時維持其完整性與穩定性。此外,由於現今的全球經濟狀況,消費性商品的製造商被迫在全球各地的數個國家中包裝其產品。這些產品在製造時變得對各種地區性條件很敏感,包括水質與化學成分、氣候條件等,所有的條件對產品完整性、穩定性以及壽命具有顯著潛在的影響。 With globalization and the increasing demand for consumer goods in the global market, it is necessary to maintain their integrity and stability while transporting these goods globally. In addition, due to today's global economic conditions, manufacturers of consumer goods are forced to package their products in several countries around the world. These products become very sensitive to various regional conditions during manufacturing, including water quality and chemical composition, climatic conditions, etc. All conditions have a significant potential impact on product integrity, stability, and longevity.
主要而言,相同或相似的因素適用於所有消費性商品,例如食物或化妝品、健康護理或美容產品、醫藥產品、藥物及其類似物的製造商。因此,本發明之一目的在於提供一種有益的容器,具體而言是針對消費性商品,例如食物或食品、個人護理產品或醫藥產品,且避免前述先前 技術中的問題。 Mainly, the same or similar factors apply to all consumer goods, such as manufacturers of food or cosmetics, health care or beauty products, pharmaceutical products, medicines and the like. Therefore, one object of the present invention is to provide a beneficial container, specifically for consumer goods, such as food or food, personal care products or pharmaceutical products, and avoid the aforementioned Problems in technology.
此外,本發明之另一目的在於提供一種製備這樣的容器的方法,以及此種容器的應用。 In addition, another object of the present invention is to provide a method for preparing such a container and the application of such a container.
根據本發明之一方面,提供一種具體而言是用於消費性商品的容器,其中該容器的內表面係至少部分塗覆一包含白藜蘆醇的塗覆層。 According to one aspect of the present invention, there is provided a container specifically for consumer goods, wherein the inner surface of the container is at least partially coated with a coating layer containing resveratrol.
根據本發明一廣泛的方面,其係關於包含一含白藜蘆醇之塗覆層的容器,具體而言是朝向該容器的內部。該容器具體而言應填充有消費性商品,具體而言為食物或食品、個人護理或醫藥產品。其特別具有一包含白藜蘆醇的內塗覆層。 According to a broad aspect of the invention, it relates to a container comprising a resveratrol-containing coating layer, specifically towards the interior of the container. The container should be specifically filled with consumer goods, specifically food or food, personal care or medical products. It especially has an inner coating layer containing resveratrol.
在本發明的一個具體實施例中,該容器(尚)未包含該消費性商品。因此,本發明之一方面係指如生產時被填充該消費性商品之前之該容器。 In a specific embodiment of the invention, the container (yet) does not contain the consumer goods. Therefore, one aspect of the invention refers to the container before being filled with the consumer goods as it is produced.
根據本發明之一方面,消費性商品(或消耗品)是那些(根據1913年版的韋伯氏辭典)能夠被消耗掉的商品。被消耗應指以任何方式花費或使用掉,例如用於營養、用於個人護理或健康或美容目的、用於醫藥或獸醫目的或以任何其他方式作為食品者。 According to one aspect of the invention, consumer goods (or consumables) are those (according to the 1913 Weber's Dictionary) that can be consumed. Consumed shall mean those who spend or use it in any way, such as for nutrition, for personal care or health or beauty purposes, for medical or veterinary purposes, or as food in any other way.
根據本發明之一具體實施例,消費性商品被理解為包含尤其是食品,例如食物、食物成分、營養品、營養補充品、飲料,以及化妝產品、美容與健康照護產品、醫藥與獸醫產品、藥品及其類似物。一般而言,該商品可包含固體、液體及/或氣體成份。根據一具體實施例,食品係被理解為可為人類或動物食用的東西,即適合被食用的東西。較佳的食物或食 物成分之一非限制性的列表包含固體食物、液體或液體化食物例如兩者皆有的嬰兒食品、(嬰兒)配方奶粉及其類似物、固體食物如罐頭食物、預煮過的膳食或正餐,如罐頭魚、半固體狀態的食物例如在汁液或醬汁中的肉、水果或蔬菜、其他食物產品或佐料、醬汁、醃料、香料及其類似物。較佳的醫藥或獸醫產品之一非限制性的列表為以片劑、膠囊、顆粒、粉劑、液體、其他固體或液體劑型及其類似物的藥物。較佳的化妝產品或美容與健康照護產品之一非限制性的列表包含乳霜、乳液、肥皂、乳劑、分散劑或液體等。 According to a specific embodiment of the present invention, consumer goods are understood to include especially foods, such as foods, food ingredients, nutritional products, nutritional supplements, beverages, as well as cosmetic products, beauty and health care products, pharmaceutical and veterinary products, Drugs and their analogs. Generally speaking, the commodity may contain solid, liquid and/or gaseous components. According to a specific embodiment, the food system is understood as something that can be eaten by humans or animals, that is, something suitable for being eaten. Better food or food One non-limiting list of food ingredients includes solid foods, liquid or liquid foods such as baby foods, (infant) formula and similar, solid foods such as canned foods, pre-cooked meals or dinners , Such as canned fish, semi-solid foods such as meat, fruits or vegetables in juices or sauces, other food products or condiments, sauces, marinades, spices and the like. One non-limiting list of preferred pharmaceutical or veterinary products is medicines in the form of tablets, capsules, granules, powders, liquids, other solid or liquid dosage forms and the like. One non-limiting list of preferred cosmetic products or beauty and health care products includes creams, lotions, soaps, emulsions, dispersants, or liquids.
如本文所用,「容器」應被廣泛地理解為包含為剛性或彈性形式的所有種類的容器或包裝(用於消費性商品)。 As used herein, "container" should be broadly understood to include all kinds of containers or packaging (for consumer goods) in a rigid or elastic form.
在本發明之一具體實施例中,該消費性商品係非飲料的消費性商品。 In a specific embodiment of the present invention, the consumer goods are non-beverage consumer goods.
在本發明之一具體實施例中,該消費性商品係食物或食品、個人護理或醫藥產品。 In a specific embodiment of the invention, the consumer goods are food or food, personal care or medical products.
在本發明之一具體實施例中,該個人護理或醫藥產品係為片劑、膠囊、顆粒、粉劑、液體、肥皂、乳液或乳霜、乳劑、分散劑或溶液或其類似物的形式。 In a particular embodiment of the invention, the personal care or medical product is in the form of tablets, capsules, granules, powders, liquids, soaps, lotions or creams, emulsions, dispersants or solutions or the like.
在另一較佳具體實施例中,該容器的內表面係整體地塗覆一包含白藜蘆醇的塗覆層。 In another preferred embodiment, the inner surface of the container is integrally coated with a coating layer containing resveratrol.
在又一較佳具體實施例中,該塗覆層包含濃度為至少0.0001重量百分比的白藜蘆醇,較佳為至少0.001重量百分比,更佳為至少0.01重量百分比,又更佳為至少0.1重量百分比,又更佳為至少1.0重量百分比。 In yet another preferred embodiment, the coating layer contains resveratrol at a concentration of at least 0.0001% by weight, preferably at least 0.001% by weight, more preferably at least 0.01% by weight, still more preferably at least 0.1% by weight The percentage is even more preferably at least 1.0 weight percent.
在又一較佳具體實施例中,該塗覆層包含濃度為至多30重量百分比的白藜蘆醇,較佳為至多10重量百分比,更佳為至多1重量百分比,又更佳為至多0.1重量百分比,又更佳為至多0.01重量百分比。 In yet another preferred embodiment, the coating layer contains resveratrol at a concentration of at most 30% by weight, preferably at most 10% by weight, more preferably at most 1% by weight, still more preferably at most 0.1% by weight The percentage is even more preferably at most 0.01 weight percent.
在又一較佳具體實施例中,該容器係由玻璃、金屬、聚合物材料、紙、紙板,或其組合所製成,在一更佳具體實施例中為鋁。 In another preferred embodiment, the container is made of glass, metal, polymer material, paper, cardboard, or a combination thereof, in a more preferred embodiment, it is aluminum.
在又一較佳具體實施例中,在該容器的內表面的該塗覆層的厚度係在介於每平方公尺約3.5至約8.4公克的範圍內,於一更佳具體實施例中為在介於每平方公尺約4.0至約8.0公克的範圍內,於一最佳具體實施例中為在介於每平方公尺約5.0至約8.0公克的範圍內。在另一具體實施例中,該塗覆層及/或容器壁的厚度可為自約0.1μm至10mm,具體而言是自約1μm至1mm。 In yet another preferred embodiment, the thickness of the coating layer on the inner surface of the container is in the range of about 3.5 to about 8.4 grams per square meter, in a more preferred embodiment is In the range of about 4.0 to about 8.0 grams per square meter, in a preferred embodiment it is in the range of about 5.0 to about 8.0 grams per square meter. In another specific embodiment, the thickness of the coating layer and/or the container wall may be from about 0.1 μm to 10 mm, specifically from about 1 μm to 1 mm.
在另一較佳具體實施例中,該塗覆層不含有環氧樹脂,在一更佳具體實施例中,該塗覆層不含有雙酚A或釋放雙酚A的物質。 In another preferred embodiment, the coating layer does not contain epoxy resin. In a more preferred embodiment, the coating layer does not contain bisphenol A or bisphenol A-releasing substances.
在又一較佳具體實施例中,該塗覆層係一熱固性塗覆層。 In another preferred embodiment, the coating layer is a thermosetting coating layer.
在又一較佳具體實施例中,在該容器中存在至少一額外的塗覆層,任選地介於該包含白藜蘆醇的塗覆層與該由金屬製成的容器壁之間。 In yet another preferred embodiment, there is at least one additional coating layer in the container, optionally between the coating layer containing resveratrol and the container wall made of metal.
根據本發明之又一方面,提供一種製備如上定義用於消費性商品之容器的方法,該方法包含下列步驟:a)提供一具有容器壁的容器,該容器壁具有一面對該容器的內部空間之內側;b)提供在該容器壁的該內側上之塗覆層,該塗覆層含有白藜蘆醇。 According to yet another aspect of the present invention, there is provided a method of preparing a container for consumer goods as defined above, the method comprising the following steps: a) providing a container having a container wall having an interior facing the container The inner side of the space; b) providing a coating layer on the inner side of the container wall, the coating layer containing resveratrol.
根據一具體實施例,上述步驟b)包含將一包含白藜蘆醇的未固化的塗覆層塗至該容器壁材料的表面,並且固化該未固化之塗覆層。 According to a specific embodiment, the above step b) includes applying an uncured coating layer containing resveratrol to the surface of the container wall material, and curing the uncured coating layer.
在該方法的一具體實施例中,該包含白藜蘆醇的未固化的塗覆層係在該容器形成之前被塗至一容器壁材料的表面。 In a specific embodiment of the method, the uncured coating layer containing resveratrol is applied to the surface of a container wall material before the container is formed.
在該方法的另一具體實施例中,該包含白藜蘆醇的未固化的塗覆層係在該容器形成之後被塗至一容器壁材料的表面。 In another specific embodiment of the method, the uncured coating layer comprising resveratrol is applied to the surface of a container wall material after the container is formed.
在另一具體實施例中,該方法包含將一本文定義之消費性商品填充至該容器的額外步驟。 In another specific embodiment, the method includes the additional step of filling a consumer product as defined herein into the container.
在又一具體實施例中,該消費性商品係食物或食品、個人護理或醫藥產品。 In yet another specific embodiment, the consumer goods are food or food, personal care or medical products.
根據本發明的又一方面,提供一由本發明之方法所獲得的容器。 According to yet another aspect of the present invention, there is provided a container obtained by the method of the present invention.
本發明的再一方面係針對根據前述任一方面或具體實施例的容器,進一步包含消費性商品,具體而言是非飲料的消費性商品。具體而言,本發明的又一方面係針對根據前述任一方面或具體實施例的容器,進一步含有或被填充有消費性商品,例如非飲料的消費性商品。 A further aspect of the present invention is directed to a container according to any one of the foregoing aspects or specific embodiments, further comprising consumer goods, specifically non-beverage consumer goods. Specifically, yet another aspect of the present invention is directed to a container according to any one of the foregoing aspects or specific embodiments, further containing or being filled with consumer goods, such as non-beverage consumer goods.
根據本發明的又一方面,提供根據本發明之前述任一方面或具體實施例的容器用於儲存消費性商品,具體而言為非飲料的消費性商品,的應用。 According to yet another aspect of the present invention, there is provided an application of a container according to any one of the foregoing aspects or specific embodiments of the present invention for storing consumer goods, specifically non-beverage consumer goods.
根據本發明的又一方面,提供將白藜蘆醇作為用於消費性商品,具體而言為非飲料的消費性商品,的容器的內表面上一塗覆層的一種添加劑的應用,。 According to yet another aspect of the present invention, there is provided the use of resveratrol as an additive for a coating layer on the inner surface of a container for consumer goods, specifically non-beverage consumer goods.
根據一較佳具體實施例,其中該消費性商品係食物或食品、個人護理或醫藥產品。 According to a preferred embodiment, the consumer goods are food or food, personal care or medical products.
本文所描述及/或請求保護的所有具體實施例與方面在本發明中被視為可組合的,除非其相反地被排除。具體而言,與該容器或其材料及該消費性商品相關的特徵具體實施例是可組合的,且在本發明的任何產品、方法或應用方面的任何組合中被揭示。 All specific embodiments and aspects described and/or claimed herein are considered combinable in the present invention unless they are excluded on the contrary. In particular, specific embodiments of features related to the container or its material and the consumer goods are combinable and are disclosed in any combination of any product, method or application aspect of the invention.
已經令人驚訝地發現,用於一消費性商品的容器,其中該容器的內表面係至少部分塗覆有一包含白藜蘆醇的塗覆層,對於品質上有害與非望的損失之避免提供良好的保護,包括介於該消費性商品與該包裝材料之間,或該消費性商品與進入或存在於該容器內部的化合物之間的反應的非期望之後果。 It has been surprisingly found that a container for a consumer product, in which the inner surface of the container is at least partially coated with a coating layer containing resveratrol, is provided for the avoidance of harmful and undesirable loss of quality. Good protection includes undesirable consequences of the reaction between the consumer product and the packaging material, or between the consumer product and the compound entering or present inside the container.
如上所述,根據本發明之一具體實施例,消費性商品被理解為包含尤其是食物、食物成分、營養品、營養補充品、飲料、化妝產品、美容與健康照護產品、醫藥與獸醫產品、藥品及其類似物。一般而言,該商品可包含固體、液體及/或氣體成份。較佳的飲料之一非限制性的列表包含葡萄酒或以葡萄酒為基底的產品、軟性飲料、果汁、牛奶或以乳清為基底的飲料及其類似物。較佳的食物或食物成分之一個非限制性的列表包含固體食物、液體或液體化食物例如兩者皆有之嬰兒食品、(嬰兒)配方奶粉等、固體食物如罐頭食物、預煮過的膳食或正餐,如罐頭魚、半固體狀態 的食物例如在汁液或醬汁中的肉、水果或蔬菜、其他食物產品或佐料、醬汁、醃料、香料及其類似物。較佳的醫藥或獸醫產品之一非限制性的列表為以片劑、膠囊、顆粒、粉劑、液體、其他固體或液體劑型及其類似物的形式之藥品。較佳的化妝產品或美容與健康照護產品之一非限制性的列表包含乳霜、乳液、肥皂、乳劑、分散劑或液體等。此外亦包括個人護理產品或化妝用品,即用於個人衛生及用於美化的商品。個人護理產品包括但不限於潤唇膏、清潔墊、古龍水、除臭劑、眼線、唇彩、唇膏、乳液、彩妝、髮油、香水、滑石粉、刮鬍膏、皮膚乳霜、濕紙巾等。亦包括藥物與含有藥物的組合物(醫藥與獸醫產品)。藥物是,在最廣之意義上,已知在人類或其他動物上具有生物效果的化學物質。 As described above, according to a specific embodiment of the present invention, consumer goods are understood to include, inter alia, food, food ingredients, nutritional products, nutritional supplements, beverages, cosmetic products, beauty and health care products, pharmaceutical and veterinary products, Drugs and their analogs. Generally speaking, the commodity may contain solid, liquid and/or gaseous components. One non-limiting list of preferred beverages includes wine or wine-based products, soft drinks, juices, milk or whey-based beverages and the like. A non-limiting list of preferred foods or food ingredients includes solid foods, liquid or liquid foods such as baby foods, (infant) formula, etc., solid foods such as canned foods, pre-cooked meals Or dinner, such as canned fish, semi-solid state Foods such as meat, fruits or vegetables in juices or sauces, other food products or condiments, sauces, marinades, spices and the like. One non-limiting list of preferred pharmaceutical or veterinary products is medicines in the form of tablets, capsules, granules, powders, liquids, other solid or liquid dosage forms and the like. One non-limiting list of preferred cosmetic products or beauty and health care products includes creams, lotions, soaps, emulsions, dispersants, or liquids. It also includes personal care products or cosmetics, that is, products used for personal hygiene and beautification. Personal care products include but are not limited to lip balm, cleansing pads, colognes, deodorants, eyeliners, lip glosses, lipsticks, lotions, make-up, hair oils, perfumes, talcum powder, shaving creams, skin creams, wipes, etc. Also includes drugs and compositions containing drugs (medicine and veterinary products). Drugs are, in the broadest sense, chemical substances known to have biological effects on humans or other animals.
根據本發明之一具體實施例,該消費性商品為飲料,具體而言是葡萄酒或以葡萄酒為基底的飲料。此處,葡萄酒被理解為包含任何得自於本領域已知的葡萄種植與葡萄酒釀造技術的飲料。於一較佳具體實施例中,該葡萄酒為紅葡萄酒。於另一較佳具體實施例中,該葡萄酒為白葡萄酒。於又一較佳具體實施例中,該葡萄酒為桃紅葡萄酒。該葡萄酒可為靜態酒或碳酸化、氣泡葡萄酒。該葡萄酒可能亦為加烈酒。以葡萄酒為基底的飲品被理解為包含任何含有如上所定義之葡萄酒的飲料。可能作為以葡萄酒為基底的飲品的實例被提及者為混有礦泉水或果汁的葡萄酒。 According to a specific embodiment of the present invention, the consumer product is a beverage, specifically a wine or a wine-based beverage. Here, wine is understood to include any beverage derived from grape growing and winemaking techniques known in the art. In a preferred embodiment, the wine is red wine. In another preferred embodiment, the wine is white wine. In another preferred embodiment, the wine is rosé wine. The wine can be static wine or carbonated, sparkling wine. The wine may also be fortified wine. Wine-based drinks are understood to include any drink containing wine as defined above. Probably mentioned as an example of wine-based drinks is wine mixed with mineral water or fruit juice.
如本文所用,「容器」應被廣泛地理解為包含為剛性或彈性形式的所有種類的容器或包裝(用於消費性商品)。 As used herein, "container" should be broadly understood to include all kinds of containers or packaging (for consumer goods) in a rigid or elastic form.
此外,帶有一包含白藜蘆醇的塗覆的容器意外地有效率地抑制或最小化包裝的消費性商品的品質惡化,具體而言為起因於氧化作用的 品質惡化。白藜蘆醇亦在葡萄皮上被發現。順式與反式構型的白藜蘆醇皆在葡萄酒(葡萄)中被發現。在此,白藜蘆醇乙詞應被理解為其最廣泛之意義。於一具體實施例中,白藜蘆醇包含順式-白藜蘆醇以及反式-白藜蘆醇。在一較佳具體實施例中,白藜蘆醇應指反式-白藜蘆醇。 In addition, a container with a coating containing resveratrol unexpectedly efficiently suppresses or minimizes the deterioration of the quality of the packaged consumer goods, specifically due to oxidation The quality deteriorates. Resveratrol was also found on the grape skin. Resveratrol in both cis and trans configurations is found in wine (grape). Here, the word resveratrol should be understood as its broadest meaning. In a specific embodiment, resveratrol includes cis-resveratrol and trans-resveratrol. In a preferred embodiment, resveratrol should refer to trans-resveratrol.
根據本發明之容器意外地有助於維持且甚至是促進該消費性商品的品質及/或壽命。令人驚奇的是,我們發現在本發明之容器中使用白藜蘆醇不僅對該消費性商品提供相對於容器材料的保護,且其增強了該消費性商品內的有益效果。非限制性地假設,白藜蘆醇涉及介於該容器(內表面)與該消費性商品之間有益的交互作用,且可能亦中和替換若非如此應出現在該容器壁的表面的有害物質,例如氧氣、其他氧化物或腐蝕性物質。 The container according to the invention unexpectedly helps to maintain and even promote the quality and/or lifespan of the consumer goods. Surprisingly, we have found that the use of resveratrol in the container of the present invention not only provides protection for the consumer product relative to the container material, but it also enhances the beneficial effects within the consumer product. It is assumed, without limitation, that resveratrol involves a beneficial interaction between the container (inner surface) and the consumer product, and may also neutralize and replace harmful substances that would otherwise appear on the surface of the container wall , Such as oxygen, other oxides or corrosive substances.
本發明對任何可能與包裝材料或與存在該容器內的化合物交互作用或反應,例如空氣或具體而言氧氣,造成該包裝材料及/或該被包裝商品的降解或分解,且最終導致該消費性商品的腐敗的消費性商品的包裝是有效的。 The present invention causes any interaction or reaction with packaging materials or compounds present in the container, such as air or specifically oxygen, to cause degradation or decomposition of the packaging material and/or the packaged goods, and ultimately to the consumption The packaging of corrupt consumer goods of sexual commodities is effective.
令人驚奇的是,我們發現使用白藜蘆醇作為該容器內部塗覆系統的一組成份,不僅對飲料如葡萄酒提供保護免於該容器材料的傷害,亦可增加在該葡萄酒中白藜蘆醇的有益效果。 Surprisingly, we found that the use of resveratrol as a group of ingredients in the internal coating system of the container not only provides protection for beverages such as wine from the material of the container, but also increases the resveratrol in the wine The beneficial effects of alcohol.
在包裝難以手持且高活性飲料如葡萄酒的情況下,其風險是該飲料與該包裝材料交互作用以及反應,而可能造成對該飲料的味道、外觀或整體完整性造成影響。此交互作用大量地由最初存在於該飲料或隨時間產生的酸或自由基所造成。 In the case of packaging that is difficult to hold and highly active beverages such as wine, the risk is that the beverage interacts and reacts with the packaging material, which may cause an impact on the taste, appearance, or overall integrity of the beverage. This interaction is largely caused by acids or free radicals originally present in the beverage or produced over time.
據此,本發明不限於葡萄酒或以葡萄酒為基底的飲品作為飲料,而亦對任何飲料的包裝是有用的,該飲料可能與包裝材料交互作用或反應而導致該包裝材料降解與分解且最終導致該飲料腐敗。該種飲料的實例為果汁,具體而言為葡萄汁、軟性飲料、檸檬汁、可樂、酸性飲料、碳酸飲料以及含有磷酸的飲料。 Accordingly, the present invention is not limited to wine or wine-based beverages as beverages, but is also useful for the packaging of any beverage, which may interact or react with the packaging material to cause degradation and decomposition of the packaging material and ultimately lead to The drink is spoiled. Examples of such drinks are fruit juices, specifically grape juice, soft drinks, lemon juice, cola, acidic drinks, carbonated drinks, and drinks containing phosphoric acid.
一般而言,若消費性商品與容器的內塗覆反應,會引起由包裝材料造成的消費性商品腐敗的問題,因此防止該包裝材料的降解與分解是重要的。 Generally speaking, if the consumer product reacts with the inner coating of the container, it will cause the corruption of the consumer product caused by the packaging material, so it is important to prevent the degradation and decomposition of the packaging material.
本案發明人驚訝地發現,作為一容器的內壁塗覆的一部份的白藜蘆醇可以保護且防止這種降解與分解。 The inventor of the present invention was surprised to find that resveratrol as a part of the inner wall coating of a container can protect and prevent such degradation and decomposition.
根據本發明之一具體實施例不受理論束縛地假設,存在於容器的塗層的白藜蘆醇可能在該面對且接觸該消費性商品的塗層表面上,以及在該塗層內(其可能亦作為延長時間的白藜蘆醇釋放的儲存庫)以及自該塗層遷移至該消費性商品中而在該消費性商品中作為活性成份。 According to a specific embodiment of the present invention, without being bound by theory, it is assumed that resveratrol present in the coating of the container may be on the surface of the coating that faces and contacts the consumer goods, and within the coating ( It may also serve as a reservoir for extended-time resveratrol release) and migrate from the coating to the consumer product as an active ingredient in the consumer product.
據觀察,作為本發明的一部份,白藜蘆醇可能具有附加所欲之功能,例如抑制非期望的反應或在容器內該消費性商品的降解。因此,例如微生物的過度生長可以導致食品的口感、香味及整體性的惡化。此外,微生物的代謝產物可加重該包裝材料破裂的問題。 It has been observed that as part of the present invention, resveratrol may have additional desired functions, such as inhibiting undesirable reactions or degradation of the consumer product in the container. Therefore, for example, excessive growth of microorganisms may cause deterioration of the taste, flavor, and integrity of the food. In addition, microbial metabolites can exacerbate the problem of cracking of the packaging material.
透過創造一種具有正面效果的白藜蘆醇的屏障,我們驚奇地發現其保護該消費性商品且增加了其穩定性與壽命。 By creating a barrier to resveratrol with positive effects, we were surprised to find that it protects the consumer product and increases its stability and longevity.
根據本發明之一方面,白藜蘆醇存在於將消費性商品添加至該容器之前的該容器的塗層內係有好處的。根據此一具體實施例,本發明之容器係指在填充消費性商品前的空容器。根據一具體實施例,本發明之容器為未使用過的容器,即從未用於填充消費性商品。這種方式提供了該容器的內壁一如上所陳具有保護作用的屏障,例如自一開始,亦即在填充該容器之時,抵擋該消費性商品之具高活性性、腐蝕性、酸性與氧化性的組成份,以及以該塗層提供一具有保護性及有利的表面。根據本發明之一具體實施例,此一自始的保護對於自與該消費性商品第一次接觸開始保持該塗覆層完整特別重要,但也保護該消費性商品的長期品質與完美。 According to one aspect of the invention, it is beneficial that resveratrol is present in the coating of the container before the consumer goods are added to the container. According to this specific embodiment, the container of the present invention refers to an empty container before it is filled with consumer goods. According to a specific embodiment, the container of the present invention is an unused container, that is, it has never been used to fill consumer goods. This method provides a protective barrier on the inner wall of the container as described above. For example, from the beginning, that is, when filling the container, it resisted the highly active, corrosive, acidic and The oxidizing component and the coating provide a protective and beneficial surface. According to a specific embodiment of the present invention, this initial protection is particularly important for keeping the coating intact since the first contact with the consumer product, but also protects the long-term quality and perfection of the consumer product.
在本發明之一較佳具體實施例中,該塗覆層包含濃度為至少0.0001重量百分比的白藜蘆醇,較佳為至少0.001重量百分比,更佳為至少0.01重量百分比,又更佳為至少0.1重量百分比,又更佳為至少1重量百分比,又更佳為至少10重量百分比,又更佳為至少30重量百分比。 In a preferred embodiment of the present invention, the coating layer comprises resveratrol at a concentration of at least 0.0001% by weight, preferably at least 0.001% by weight, more preferably at least 0.01% by weight, still more preferably at least 0.1 weight percent, still more preferably at least 1 weight percent, still more preferably at least 10 weight percent, still more preferably at least 30 weight percent.
在本發明之另一較佳具體實施例中,該塗覆層包含濃度為至多70重量百分比的白藜蘆醇,較佳為至多30重量百分比,更佳為至多10重量百分比,又更佳為至多1重量百分比,又更佳為至多0.1重量百分比,又更佳為至多0.01重量百分比,又更佳為至多0.001重量百分比。 In another preferred embodiment of the present invention, the coating layer contains resveratrol at a concentration of at most 70% by weight, preferably at most 30% by weight, more preferably at most 10% by weight, and still more preferably At most 1% by weight, still more preferably at most 0.1% by weight, still more preferably at most 0.01% by weight, still more preferably at most 0.001% by weight.
在本發明之一尤佳之具體實施例中,根據本發明該塗覆層包含濃度為自0.0001至10重量百分比的白藜蘆醇,在一更佳具體實施例中為自0.1至5重量百分比,較佳為0.5至1重量百分比,在另一更佳具體實施例中為 自0.001至0.05重量百分比,較佳為0.005至0.01重量百分比。 In a particularly preferred embodiment of the present invention, the coating layer according to the present invention contains resveratrol at a concentration of from 0.0001 to 10 weight percent, and in a more preferred embodiment from 0.1 to 5 weight percent , Preferably 0.5 to 1 weight percent, in another more preferred embodiment is From 0.001 to 0.05 weight percent, preferably 0.005 to 0.01 weight percent.
根據本發明之一具體實施例,上述重量百分比範圍係基於該含有白藜蘆醇的塗覆層的總重量。若該容器中存在多於一塗覆層,根據本發明之一具體實施例,上述重量百分比的範圍係基於所有塗覆層的總重量。根據本發明之另一具體實施例,上述之重量百分比範圍係基於僅限含有白藜蘆醇的塗覆層的總重量。 According to a specific embodiment of the present invention, the above weight percentage range is based on the total weight of the resveratrol-containing coating layer. If there is more than one coating layer in the container, according to a specific embodiment of the present invention, the above weight percentage range is based on the total weight of all coating layers. According to another embodiment of the present invention, the above weight percentage range is based on the total weight of the coating layer containing only resveratrol.
根據本發明之一方面,橫越該塗覆層的橫切面,白藜蘆醇的濃度亦可能不同。例如,根據一具體實施例,在或接近面對該消費性商品的塗覆層表面的白藜蘆醇的濃度可能高於距離該表面較遠的塗層的部分。這麼一來,根據本發明之一具體實施例,可能增進該塗覆層的表面的保護效果,例如,在填充消費性商品之前在未使用的容器中,如此當消費性商品被填充到該容器內時就存在一有利的保護層。根據另一具體實施例,亦可呈現相反的濃度排列而可在該塗覆層中提供白藜蘆醇的較長期儲存庫。 According to one aspect of the invention, the concentration of resveratrol may also vary across the cross-section of the coating layer. For example, according to a specific embodiment, the concentration of resveratrol at or near the surface of the coating layer facing the consumer product may be higher than the portion of the coating layer farther from the surface. In this way, according to a specific embodiment of the present invention, it is possible to enhance the protective effect of the surface of the coating layer, for example, in an unused container before filling the consumer goods, so that when the consumer goods are filled into the container Inside, there is a favorable protective layer. According to another specific embodiment, the opposite concentration arrangement may also be present to provide a longer-term storage of resveratrol in the coating layer.
根據本發明之容器提供消費性商品的製造商與包裝商一改進的包裝其商品之方法。 The container according to the invention provides an improved method for packaging consumer goods by manufacturers and packagers of consumer goods.
該含有白藜蘆醇內部屏障及其應用方法可為一整體包裝系統的部分,該系統具有在正常容器製造過程中可應用於任何容器的能力。 The resveratrol-containing internal barrier and its application method can be part of an integrated packaging system that has the ability to be applied to any container during the normal container manufacturing process.
此外,根據本發明之容器可在一非冷藏的海運容器內運輸含有敏感消費性商品的終產物,因此減少碳足跡。 In addition, the container according to the present invention can transport the final product containing sensitive consumer goods in a non-refrigerated marine container, thus reducing the carbon footprint.
在一較佳具體實施例中,該容器係包含或由金屬、聚合物材料例如塑膠材料、紙、紙板、玻璃,或其組合所製成,在一更佳具體實施例中為鋁。本發明對於任何在本文中提及的消費性商品的儲存是有效的, 包括該等酸性、腐蝕性、氧化性,或能夠以任何方式與包裝材料反應者,以及該等對環境因子與存在於該容器內的化合物敏感者。如上所述,本文所用之容器乙詞包含為剛性或彈性形式的任何用於消費性商品的包裝或包裝材料。該容器可能具有用於包裝各個商品的適當形式或形狀。該容器可能為,例如但不限於罐頭、包裝袋、罐頭、罐、槽、碗、瓶、桶或其類似物。根據一具體實施例,該容器係為一用於藥物的包裝。根據一具體實施例,該容器亦可為氣泡包裝的形式且任選的該抗氧化劑可存在於金屬箔上及/或該氣泡包裝的塑膠膜上。 In a preferred embodiment, the container comprises or is made of metal, polymer material such as plastic material, paper, cardboard, glass, or a combination thereof, and in a more preferred embodiment is aluminum. The present invention is effective for the storage of any consumer goods mentioned herein, Include those that are acidic, corrosive, oxidizing, or capable of reacting with packaging materials in any way, and those that are sensitive to environmental factors and compounds present in the container. As mentioned above, the term "container" as used herein includes any packaging or packaging materials for consumer goods in a rigid or elastic form. The container may have a suitable form or shape for packaging various goods. The container may be, for example, but not limited to, cans, bags, cans, cans, troughs, bowls, bottles, barrels, or the like. According to a specific embodiment, the container is a packaging for medicine. According to a specific embodiment, the container may also be in the form of a bubble wrap and the optional antioxidant may be present on the metal foil and/or the plastic film of the bubble wrap.
在本發明之一較佳具體實施例中,該塗覆層作為一雙向屏障。一雙向屏障在本發明之內容中應被理解為不僅是保護該消費性商品免於與該包裝材料之間非期望的交互作用而導致該消費性商品的品質惡化或改變;此外,該屏障亦應保護該包裝材料免於與該消費性商品之間非期望的交互作用而造成該容器或其完整性可能的危害。 In a preferred embodiment of the present invention, the coating layer acts as a bidirectional barrier. A two-way barrier should be understood in the context of the present invention not only to protect the consumer product from undesired interaction with the packaging material resulting in deterioration or change in the quality of the consumer product; in addition, the barrier The packaging material should be protected from unintended interactions with the consumer goods, which may cause harm to the container or its integrity.
根據本發明之數個方面,根據本發明之容器、步驟以及應用可以尤其是減少食物中毒(特別是來自罐頭食物)的機率或增加該產品的庫存壽命(該產品的壽命與穩定性)。其亦可幫助達成各種針對包裝的消費性商品度過數種全球氣候條件的各種適合運輸條件。其可能進一步減少防腐劑的需求,例如以鹽/鈉為基底的防腐劑,或例如以山梨酸作為在罐頭食物內的防腐劑。其亦可以例如防止容器或其內襯上有害的腐蝕作用。在許多情況下,它們可能維持或穩定天然風味或是增加作為消耗性商品的食品的天然風味。可透過例如減少/消除在食物中無用的細菌的形成而達到減少自由基的形成。因此,可減少感染的機率。針對醫藥產品,則可增加其穩定性 與品質。 According to several aspects of the present invention, the container, procedure and application according to the present invention can especially reduce the probability of food poisoning (especially from canned food) or increase the product's inventory life (life and stability of the product). It can also help to achieve a variety of suitable transportation conditions for packaging consumer goods through several global climate conditions. It may further reduce the demand for preservatives, such as salt/sodium based preservatives, or for example sorbic acid as a preservative in canned food. It can also prevent harmful corrosion on the container or its lining, for example. In many cases, they may maintain or stabilize the natural flavor or increase the natural flavor of foods that are expendable commodities. The reduction of free radical formation can be achieved, for example, by reducing/eliminating the formation of useless bacteria in food. Therefore, the probability of infection can be reduced. For pharmaceutical products, it can increase their stability With quality.
根據一具體實施例,原則上,本領域具通常知識者已知之所有塗覆組合物或漆可在本發明中被用來作為塗覆層。製備的一般方法的實例以及示例性的塗層的應用係揭露於歐洲專利申請案公開號EP 2457840 A1「包裝材料7.用於食物的金屬包裝」中(ILSI歐洲包裝材料特別委員會的出版物,2007年9月,可見於https://europa.eu/sinapse/sinapse/index.cfm?fuseaction=lib.attachment&lib_id=C5C03DA0-ED72-0D54-309D55AA14F6C62F&attach=LIB_DOC_EN)或是「初步產業特性描述:金屬罐頭之製造-表面塗覆」(美國環境保護署的出版物,1998年9月,可見於http://www.epa.gov/ttnatw01/coat/mcan/pic-can.pdf)。 According to a specific embodiment, in principle, all coating compositions or lacquers known to those skilled in the art can be used as coating layers in the present invention. Examples of general methods of preparation and the application of exemplary coatings are disclosed in European Patent Application Publication No. EP 2457840 A1 "Packaging Materials 7. Metal Packaging for Food" (ILSI Publication of the European Special Committee on Packaging Materials, September 2007, can be seen at https://europa.eu/sinapse/sinapse/index.cfm?fuseaction=lib.attachment&lib_id=C5C03DA0-ED72-0D54-309D55AA14F6C62F&attach=LIB_DOC_EN) or "Preliminary Industry Characterization: Metal Cans" Manufacturing-Surface Coating" (US Environmental Protection Agency publication, September 1998, available at http://www.epa.gov/ttnatw01/coat/mcan/pic-can.pdf ).
用於金屬及非金屬表面的塗覆組合物與塗覆層已為本領域具一般知識者所知。該組合物係依表面性質及該金屬或非金屬表面的黏著性,以及與要被包裝的消費性商品的相容性由本領域具一般知識者所選。一應用該含有白藜蘆醇塗層之較佳的非金屬材料(表面)為聚合物或塑膠表面。白藜蘆醇可以在該塗層形成前、中、後被輕易的加入。 Coating compositions and coatings for metallic and non-metallic surfaces are known to those of ordinary skill in the art. The composition is selected by a person having ordinary knowledge in the art according to the surface properties, the adhesion of the metal or non-metal surface, and the compatibility with the consumer goods to be packaged. One application The preferred non-metallic material (surface) containing resveratrol coating is a polymer or plastic surface. Resveratrol can be easily added before, during and after the coating is formed.
先前已被用於如鋁罐之容器的內塗層(塗覆層)的漆主要是基於含雙酚A(Bisphenol A,BPA)的化合物,如環氧樹脂。根據本發明之一具體實施例,避免在飲料容器的塗覆層中使用雙酚A或釋放雙酚A的物質。根據一特定之具體實施例,該塗覆層不應含有任何以下可能的危險物質:福馬林、高錳酸鉀(KMnO4)、酞酸二丁酯(dibutyl phthalate,DBP)、鄰苯二甲酸雙(2-乙基己基)酯(bis(2-ethylhexyl)phthalate,DEHP)、鄰苯二甲酸二異丁酯(diisobutyl phthalate,DIBP)、磷苯二甲酸二甲酯(dimethyl phthalate, DMP)、鄰苯二甲酸二乙酯(diethyl phthalate,DEP)、己二酸雙(2-乙基己基)酯(bis(2-ethylhexyl)adipate,DEHA)、鄰苯二甲酸二癸酯(diisodecyl phthalate,DIDP)、鄰苯二甲酸二異壬酯(diisononyl phthalate,DINP)。 The lacquers that have been previously used for inner coatings (coating layers) of containers such as aluminum cans are mainly based on compounds containing Bisphenol A (BPA), such as epoxy resins. According to a specific embodiment of the present invention, the use of bisphenol A or bisphenol A-releasing substances in the coating layer of the beverage container is avoided. According to a specific embodiment, the coating layer should not contain any of the following possible hazardous substances: formalin, potassium permanganate (KMnO4), dibutyl phthalate (DBP), bisphthalate (2-ethylhexyl) phthalate (bis (2-ethylhexyl) phthalate, DEHP), diisobutyl phthalate (DIBP), dimethyl phthalate (dimethyl phthalate, DMP), diethyl phthalate (DEP), bis(2-ethylhexyl) adipate (DEHA), diisodecyl phthalate (diisodecyl phthalate (DIDP), diisononyl phthalate (DINP).
於另一具體實施例中,該漆不含有環氧樹脂,在另一具體實施例中,該塗覆層不含有雙酚A或釋放雙酚A的物質。 In another specific embodiment, the paint does not contain epoxy resin. In another specific embodiment, the coating layer does not contain bisphenol A or bisphenol A-releasing substances.
於另一較佳具體實施例中,該塗覆層為一熱固化塗覆層。 In another preferred embodiment, the coating layer is a thermosetting coating layer.
於一較佳具體實施例中,根據本發明之漆符合所有USFDA的規範或其他國家食品安全規範,具體而言該漆為食品等級。這樣的漆為本領域具一般知識者所知悉且為市售。所有可用之漆皆可用於本發明中。 In a preferred embodiment, the paint according to the present invention meets all USFDA regulations or other national food safety regulations, specifically the paint is food grade. Such paints are known to those of ordinary skill in the art and are commercially available. All available paints can be used in the present invention.
根據本發明之容器的塗覆層厚度應較佳地選擇使得在一消費性商品中的侵略性元素不會與該容器材料接觸,且使得該塗層提供要被包裝的商品足夠的保護。根據本發明,可得到延長的庫存壽命與提高的產品完整性。 The thickness of the coating layer of the container according to the present invention should preferably be selected so that the aggressive elements in a consumer product will not come into contact with the container material, and that the coating provides sufficient protection for the product to be packaged. According to the present invention, an extended inventory life and improved product integrity can be obtained.
於一較佳具體實施例中,在該容器的內表面的該塗覆層的厚度係在介於每平方公尺約3.5至約8.4公克的範圍內,於一更佳具體實施例中為在介於每平方公尺約4.0至約8.0公克的範圍內,於一最佳具體實施例中為在介於每平方公尺約5.0至約8.0公克的範圍內。在另一具體實施例中,該塗覆層及/或容器壁的厚度可為自約0.1μm至10mm,具體而言是自約1μm至1mm。 In a preferred embodiment, the thickness of the coating layer on the inner surface of the container is in the range of about 3.5 to about 8.4 grams per square meter, in a more preferred embodiment is It ranges from about 4.0 to about 8.0 grams per square meter, and in a preferred embodiment it ranges from about 5.0 to about 8.0 grams per square meter. In another specific embodiment, the thickness of the coating layer and/or the container wall may be from about 0.1 μm to 10 mm, specifically from about 1 μm to 1 mm.
於一較佳具體實施例中,該塗覆層一致地分佈於整個容器的內壁,使得該內壁整體地塗覆有該含有白藜蘆醇的塗層。 In a preferred embodiment, the coating layer is uniformly distributed on the inner wall of the entire container, so that the inner wall is entirely coated with the resveratrol-containing coating.
於另一較佳具體實施例中,該含有白藜蘆醇的塗覆層為一非 滲透層,即該消費性商品無法滲透該包含白藜蘆醇的塗覆層以防止該消費性商品與該包裝材料交互作用。 In another preferred embodiment, the coating layer containing resveratrol is a non- A permeable layer, that is, the consumer product cannot penetrate the resveratrol-containing coating layer to prevent the consumer product from interacting with the packaging material.
根據本發明之一具體實施例,用於一消費性商品的容器的壁可包含一或多層壁。若該容器的壁只由一層組成,根據本發明之一具體實施例,這一層,即該容器的壁可含有白藜蘆醇。換句話說,該塗覆層即為該容器之壁。本發明此種具體實施例之一實例為,由一層塑膠膜所製成的容器,該塑膠膜密封在一起以形成一種的袋子,以用於消費性商品例如即用膳食。該容器之壁,即該單層塑膠膜包含白藜蘆醇且同時為該容器之壁。 According to a specific embodiment of the invention, the wall of the container for a consumer product may comprise one or more walls. If the wall of the container is composed of only one layer, according to a specific embodiment of the present invention, this layer, that is, the wall of the container may contain resveratrol. In other words, the coating layer is the wall of the container. An example of such a specific embodiment of the present invention is a container made of a layer of plastic film which is sealed together to form a bag for use in consumer goods such as ready-to-use meals. The wall of the container, that is, the single-layer plastic film contains resveratrol and at the same time is the wall of the container.
根據本發明之一較佳具體實施例,含有白藜蘆醇之層(如塗覆層,或該容器之壁)為一含有或基本上或完全由聚合物組成之層。具體較佳者為具有可以與白藜蘆醇交互作用的官能基的聚合物,較佳地與白藜蘆醇的OH基團作用者。這種聚合物的非限制性的實例為該等具有能夠與白藜蘆醇形成氫鍵的官能基的聚合物。根據本發明之適合的聚合物的較佳實例為包含帶有氧、氮、硫、氯或氟雜原子的官能基之聚合物。 According to a preferred embodiment of the present invention, the layer containing resveratrol (such as the coating layer, or the wall of the container) is a layer containing or consisting essentially or entirely of polymer. Specifically preferred are polymers having functional groups that can interact with resveratrol, preferably those that interact with the OH group of resveratrol. Non-limiting examples of such polymers are those polymers having functional groups capable of forming hydrogen bonds with resveratrol. Preferred examples of suitable polymers according to the present invention are polymers containing functional groups bearing heteroatoms of oxygen, nitrogen, sulfur, chlorine or fluorine.
根據一較佳具體實施例,包含在該層(如該塗覆層,或該容器之壁)的所有、基本上所有或至少一部份的白藜蘆醇不與該層的組成份,具體而言為在該層中存在的聚合物,共價結合。非共價結合的白藜蘆醇可遷移且補充在該容器的內表面或在該被包裝的消費性商品內的白藜蘆醇。於另一方面,至少一部分的白藜蘆醇結合且固定於該層的組成份可在某些情況下幫助白藜蘆醇維持在一其較佳的位置上,具體而言是直接與該被包裝的商品直接接觸的位置上。 According to a preferred embodiment, all, substantially all, or at least a portion of resveratrol contained in the layer (such as the coating layer, or the wall of the container) is not a component of the layer, specifically It is said that the polymer present in this layer is covalently bonded. Non-covalently bound resveratrol can migrate and replenish resveratrol on the inner surface of the container or within the packaged consumer product. On the other hand, at least a part of the components of resveratrol bound and fixed to the layer can in some cases help resveratrol to maintain a better position, specifically directly with the Where the packaged goods are in direct contact.
在又另一較佳具體實施例中,該內壁係部分塗覆含有白藜蘆 醇的塗覆層。例如,該容器可能只在該容器最容易裂開或失敗的區域塗覆有含有白藜蘆醇的塗覆層。或者,該內壁可能以點狀方式塗覆有含有白藜蘆醇的塗覆層。這些點可能提供足夠的白藜蘆醇以獲得本發明之有益效果。根據此具體實施例,未塗覆該含有白藜蘆醇的塗覆層之區域可塗覆不同的塗覆層以防止該消費性商品與該包裝材料交互作用。 In yet another preferred embodiment, the inner wall is partially coated with resveratrol Alcohol coating. For example, the container may be coated with a coating layer containing resveratrol only in the area where the container is most likely to crack or fail. Alternatively, the inner wall may be coated with a coating layer containing resveratrol in a dot-like manner. These points may provide enough resveratrol to obtain the beneficial effects of the present invention. According to this specific embodiment, the areas not coated with the resveratrol-containing coating layer may be coated with different coating layers to prevent the consumer goods from interacting with the packaging material.
本發明之又一方面係關於一種製備一用於如上定義消費性商品之容器的方法,該方法包含下列步驟:(a)提供一具有容器壁的容器,該容器壁具有一面對該容器的內部空間之內側;(b)提供在該容器壁的該內側上之塗覆層,該塗覆層含有白藜蘆醇。 Yet another aspect of the present invention relates to a method of preparing a container for consumer goods as defined above, the method comprising the following steps: (a) providing a container having a container wall having a container facing the container The inner side of the inner space; (b) providing a coating layer on the inner side of the container wall, the coating layer containing resveratrol.
如本文所述,可使用任何適合提供一容器之內部空間以用於包裝消費性商品的容器。該容器具有一容器壁且此一容器壁具有面對該容器內部空間的內側。可使用如本文所述或被本領域具一般知識者認為適當之任何含有白藜蘆醇的塗覆層。根據一方面,該容器可能僅具有一層以作為該容器壁,因此該塗覆層同時也是該容器壁。此外,亦可在該容器壁中提供附加層。 As described herein, any container suitable for providing the internal space of a container for packaging consumer goods can be used. The container has a container wall and the container wall has an inner side facing the inner space of the container. Any coating layer containing resveratrol as described herein or deemed appropriate by those of ordinary skill in the art may be used. According to one aspect, the container may have only one layer as the container wall, so the coating layer is also the container wall. In addition, an additional layer can also be provided in the container wall.
根據另一方面,本發明進一步提供一種製備一用於消費性商品之容器的方法,包含將一包含白藜蘆醇的未固化的塗覆層塗至一容器壁材料的表面,並且固化該未固化的塗覆層之步驟。 According to another aspect, the present invention further provides a method of preparing a container for consumer goods, comprising applying an uncured coating layer comprising resveratrol to the surface of a container wall material, and curing the untreated Step of curing the coating.
該未固化的塗覆層可以被塗至該容器壁材料,如透過本領域習知之標準噴塗槍。 The uncured coating layer can be applied to the container wall material, such as through a standard spray gun known in the art.
在本發明之一具體實施例中,該包含白藜蘆醇的未固化的塗 覆層係在該容器形成之前被塗至該容器壁材料的表面。此一具體實施例之優點為在該材料被形成中空容器之前,該包含白藜蘆醇的未固化的塗覆層可被更為一致地塗抹且分佈於該容器壁材料的表面上。於另一較佳具體實施例中,該包含白藜蘆醇的塗覆層可以薄膜或箔片的形式貼附或塗抹於該容器壁材料的一表面,其較佳為在形成該容器之前或之後層壓或其他結合於該容器壁材料的方式。根據本發明之一具體實施例,該包含白藜蘆醇的塗覆層之製備,如透過使用箔片,不需以延長之時間大量加熱。此外,若進行該層之固化,可使用除了熱固化外的其他固化方式,否則加熱的時間及溫度會被限制。 In one embodiment of the invention, the uncured coating containing resveratrol The coating is applied to the surface of the container wall material before the container is formed. The advantage of this particular embodiment is that before the material is formed into a hollow container, the uncured coating layer containing resveratrol can be applied more uniformly and distributed on the surface of the container wall material. In another preferred embodiment, the resveratrol-containing coating layer may be attached or smeared on a surface of the container wall material in the form of a film or a foil, preferably before forming the container or It is then laminated or otherwise bonded to the container wall material. According to a specific embodiment of the present invention, the preparation of the resveratrol-containing coating layer, such as by using a foil, does not require a large amount of heating for an extended period of time. In addition, if the layer is cured, other curing methods besides thermal curing can be used, otherwise the heating time and temperature will be limited.
在本發明之另一具體實施例中,該包含白藜蘆醇的未固化的塗覆層係在該容器形成之後被塗至該容器壁材料的表面。此一具體實施例之優點為標準容器可獲自大量製造商,且隨後提供本發明之該塗覆層以得到一具有根據本發明之優點的容器。此外,根據另一具體實施例,白藜蘆醇可被加入至該塗覆層的至少一組合物中,而其他生產過程維持不變。 In another embodiment of the present invention, the uncured coating layer containing resveratrol is applied to the surface of the container wall material after the container is formed. The advantage of this particular embodiment is that standard containers can be obtained from a large number of manufacturers, and the coating layer of the present invention is then provided to obtain a container having the advantages according to the present invention. In addition, according to another specific embodiment, resveratrol can be added to at least one composition of the coating layer, while other production processes remain unchanged.
在本發明之一方面,白藜蘆醇,例如一包含該白藜蘆醇的溶液,可被噴灑至一包含具有一或多層之容器壁的容器的內表面上。 In one aspect of the invention, resveratrol, such as a solution containing the resveratrol, can be sprayed onto the inner surface of a container containing one or more container walls.
在另一具體實施例中,在塗覆層已被塗至該容器的內壁(或表面)之後,但在該消費性商品被填充到該容器內之前,添加白藜蘆醇,例如噴灑在該塗覆層的表面上。根據進一步的具體實施例,在該塗覆層固化之後,但在該消費性商品被填充到該容器內之前,白藜蘆醇被添加到該塗覆層,例如噴灑於其上。 In another specific embodiment, after the coating layer has been applied to the inner wall (or surface) of the container, but before the consumer goods are filled into the container, resveratrol is added, for example, sprayed on On the surface of the coating layer. According to a further specific embodiment, after the coating layer is cured, but before the consumer goods are filled into the container, resveratrol is added to the coating layer, for example, sprayed thereon.
在本發明之一較佳具體實施例中,該方法包含將一消費性商 品填充至該容器的額外步驟。根據一具體實施例,其在包含白藜蘆醇的塗覆層已被提供於該容器的內表面之後完成。 In a preferred embodiment of the present invention, the method includes a consumer The additional step of filling the product into the container. According to a specific embodiment, it is done after the coating layer containing resveratrol has been provided on the inner surface of the container.
在本發明之內文中,應當被理解的是,該容器的內表面應指面對該容器的內面的該容器壁的內側。因此,根據本發明之容器具有一容器壁,例如由金屬如鋁所製成,且這一容器壁具有面對該容器的外部的外側與面對該容器內部的內側。該容器之內側(或表面),根據本發明之一具體實施例,因此可能塗覆一或多層,至少一層包含白藜蘆醇。於本發明之一具體實施例中,提供只具有一層(塗覆層)之容器(壁)的內表面。該層包含根據本發明的白藜蘆醇。於本發明之另一具體實施例中,提供多於一層的該容器(壁)的內表面。在這種情況下,一或多層可包含白藜蘆醇。 In the context of the present invention, it should be understood that the inner surface of the container should refer to the inside of the container wall facing the inner surface of the container. Therefore, the container according to the invention has a container wall, for example made of metal such as aluminum, and this container wall has an outside facing the outside of the container and an inside facing the inside of the container. The inside (or surface) of the container, according to one embodiment of the present invention, may therefore be coated with one or more layers, at least one layer containing resveratrol. In one embodiment of the present invention, an inner surface of a container (wall) having only one layer (coating layer) is provided. This layer contains resveratrol according to the invention. In another embodiment of the present invention, more than one layer of the inner surface of the container (wall) is provided. In this case, one or more layers may contain resveratrol.
根據本發明之一廣泛的方面,該容器因此包含一由一或多層組成的容器壁,其中至少一層含有白藜蘆醇。 According to one broad aspect of the invention, the container therefore comprises a container wall consisting of one or more layers, at least one of which contains resveratrol.
根據一具體實施例,在包含白藜蘆醇的層與該容器壁之間可存在一或多個不包含白藜蘆醇的層。此外,根據一具體實施例,一或多個不包含白藜蘆醇的層可存在於該包含白藜蘆醇的(塗覆)層以及該容器的外部之間。 According to a specific embodiment, there may be one or more layers not containing resveratrol between the layer containing resveratrol and the wall of the container. Furthermore, according to a specific embodiment, one or more layers not containing resveratrol may be present between the (coating) layer containing resveratrol and the outside of the container.
根據另一具體實施例,一或多個不包含白藜蘆醇的層可能存在於該包含白藜蘆醇的層與該容器的內部之間,即該消費性商品可被填充於其中的該容器之空腔。根據一進一步的具體實施例,該包含白藜蘆醇的層為直接面對該容器的內部的層,即一旦該容器填充該消費性商品,分別直接接觸該容器空腔或該消費性商品。 According to another specific embodiment, one or more layers that do not contain resveratrol may exist between the layer that contains resveratrol and the interior of the container, that is, the consumer goods can be filled in the The cavity of the container. According to a further specific embodiment, the resveratrol-containing layer is a layer directly facing the interior of the container, that is, once the container is filled with the consumer goods, directly contacting the container cavity or the consumer goods, respectively.
在本發明之一具體實施例中,白藜蘆醇可包含在任何位於一 罐頭的外鋁殼(容器壁)的內側之層中。在一較佳具體實施例中,白藜蘆醇僅包含在一或多個位於該罐頭的外鋁殼內側的層內,其可直接或透過另外一層白藜蘆醇及/或該消費性商品可滲透之層與該消費性商品交互作用。於另一較佳具體實施例中,白藜蘆醇係包含於一個能夠與該消費性商品交互作用的層內。 In one embodiment of the present invention, resveratrol can be included in any In the inner layer of the outer aluminum shell (container wall) of the can. In a preferred embodiment, resveratrol is only contained in one or more layers inside the outer aluminum shell of the can, which can be directly or through another layer of resveratrol and/or the consumer goods The permeable layer interacts with the consumer product. In another preferred embodiment, resveratrol is contained in a layer that can interact with the consumer product.
在另一較佳具體實施例中,該未固化的塗覆層包含游離的金屬自由基。將游離的金屬自由基添加至該未固化的漆上將會減少烘烤與固化溫度以及固化時間,導致額外減少將一消費性商品包裝至一根據本發明之容器中所需之能源。 In another preferred embodiment, the uncured coating layer contains free metal radicals. Adding free metal free radicals to the uncured paint will reduce the baking and curing temperature and curing time, resulting in an additional reduction in the energy required to package a consumer product into a container according to the invention.
在一具體實施例中,該未固化的塗覆層在自180至250℃的溫度下,較佳地在自180至220℃的溫度下,固化80至230秒。 In a specific embodiment, the uncured coating layer is cured at a temperature of from 180 to 250°C, preferably at a temperature of from 180 to 220°C, for 80 to 230 seconds.
根據本發明,可將一包含白藜蘆醇的頂層塗覆層塗至該容器之內部,使該含有白藜蘆醇之層可與該消費性商品接觸。 According to the present invention, a top coating layer containing resveratrol can be applied to the inside of the container so that the layer containing resveratrol can come into contact with the consumer goods.
在又另一較佳具體實施例中,存在至少一額外的塗覆層。例如,底層代表一注入白藜蘆醇、不含BPA、抗腐蝕的塗覆層,其包含一,具體而言是以水為基底的,單體增強劑,其驅動白藜蘆醇至該頂層塗覆層以接觸該消費性商品。 In yet another preferred embodiment, there is at least one additional coating layer. For example, the bottom layer represents a resveratrol-infused, BPA-free, corrosion-resistant coating layer that contains a, specifically water-based, monomer enhancer that drives resveratrol to the top layer The layer is coated to contact the consumer goods.
根據本發明之一具體實施例,可以確保在製備該容器的最後步驟(即充填之前),白藜蘆醇係位於該容器的塗覆層內表面上,該容器係與該消費性商品接觸。 According to a specific embodiment of the present invention, it can be ensured that in the final step of preparing the container (ie before filling), resveratrol is located on the inner surface of the coating layer of the container, and the container is in contact with the consumer goods.
本發明亦提供將本文所述之容器用於儲存一消費性商品的應用。在一較佳具體實施例中,該容器係用於儲存非飲料的消費性商品。 The invention also provides an application of the container described herein for storing a consumer product. In a preferred embodiment, the container is used to store non-beverage consumer goods.
此外,本發明提供將白藜蘆醇作為一塗覆層之添加劑的應用,該塗覆層具體而言是一容器的內表面上的塗覆層,該容器具體而言是用於消費性商品。 In addition, the present invention provides the use of resveratrol as an additive to a coating layer, which is specifically a coating layer on the inner surface of a container, which is specifically used for consumer goods .
如本文所述,本發明所有的具體實施例皆被視為可以任何形式組合,除非本領域具一般知識者認為這樣的組合不具有技術意義。 As described herein, all specific embodiments of the present invention are considered to be combinable in any form, unless those of ordinary skill in the art consider such a combination to be of no technical significance.
實施例1 Example 1
含有白藜蘆醇的漆(塗覆層)之製備 Preparation of paint (coating layer) containing resveratrol
不含雙酚A之含有聚酯丙烯酸酯之層(根據PCT專利公開號WO 2008036629 A2的實施例2所製備)Bisphenol A-free layer containing polyester acrylate (prepared according to Example 2 of PCT Patent Publication No. WO 2008036629 A2)
一2公升的燒瓶配備有一攪拌器、填充管柱、冷凝器、熱電偶、加熱包以及氮氣層。將以下物質加入該燒瓶中:498.6公克的丙二醇、80.1公克的三羥甲基丙烷、880.1公克的對苯二甲酸、40.0公克的間苯二甲酸,以及2.0公克的FASCAT 9100丁基羥基氧錫烷催化劑(購自Total石化美國公司,休士頓,美國)。 A 2 liter flask is equipped with a stirrer, packed column, condenser, thermocouple, heating bag, and nitrogen blanket. Add the following to the flask: 498.6 grams of propylene glycol, 80.1 grams of trimethylolpropane, 880.1 grams of terephthalic acid, 40.0 grams of isophthalic acid, and 2.0 grams of FASCAT 9100 butylhydroxyoxystannane Catalyst (purchased from Total Petrochemicals USA, Houston, USA).
在氮氣層之下,將燒瓶內容物緩慢地加熱至225℃到235℃,並將得自縮聚反應的水分蒸餾掉。一旦該反應混合物變得澄清,且在該管柱頂部的溫度下降後,冷卻該反應混合物至160℃,且將85.5公克的間苯二甲酸以及16.0公克的無水順丁烯二酸加入該燒瓶中。在氮氣層之下,將該反應混合物緩慢地再加熱至220℃到230℃。 Under the nitrogen blanket, the contents of the flask were slowly heated to 225°C to 235°C, and the water from the polycondensation reaction was distilled off. Once the reaction mixture became clear, and after the temperature at the top of the column dropped, the reaction mixture was cooled to 160°C, and 85.5 g of isophthalic acid and 16.0 g of anhydrous maleic acid were added to the flask . Under a nitrogen blanket, the reaction mixture was slowly reheated to 220°C to 230°C.
一旦反應混合物變的澄清,且在該填充管柱頂部的溫度下降後,冷卻該燒瓶內的反應混合物至200℃,將該填充管柱以共沸蒸餾用的 Dean & Stark管柱置換,並將30.0公克的二甲苯加入該燒瓶中。燒瓶中的內容物在氮氣層下再次加熱至回流溫度,且蒸餾出更多的反應水份直到反應混合物的酸值低於5。將該燒瓶中的內容物冷卻至145℃至150℃,然後加入744.6公克的丁基乙二醇、104.7公克的正丁醇,以及219.6公克的二甲苯以形成溶解的聚酯溶液。 Once the reaction mixture became clear, and after the temperature at the top of the packed column dropped, the reaction mixture in the flask was cooled to 200°C, and the packed column was used for azeotropic distillation. The Dean & Stark column was replaced and 30.0 grams of xylene was added to the flask. The contents of the flask were heated to the reflux temperature again under a nitrogen blanket, and more reaction water was distilled off until the acid value of the reaction mixture was below 5. The contents of the flask were cooled to 145°C to 150°C, and then 744.6 g of butyl glycol, 104.7 g of n-butanol, and 219.6 g of xylene were added to form a dissolved polyester solution.
一5公升的燒瓶配備有一攪拌器、回流冷凝器、熱電偶、加熱包以及氮氣層。將一如上所述方法之溶解的聚酯溶液之實例(1782.0公克)及丁基乙二醇(123.0公克)置於該5公升的燒瓶內並在氮氣層下預熱至120℃。於另一燒瓶中預先混合321.0公克的丙烯酸乙酯、68.3公克的冰丙烯酸、96.1公克的苯乙烯以及11.9公克的VAZO 67自由基引發劑(2,2'-偶氮二(2-甲基丁腈),購自Du Pont de Nemours公司,威爾明頓,達拉瓦州,美國)。在氮氣層下120℃至122℃的溫度下,135分鐘的期間內,將該單體與引發劑的混合物加入該聚酯溶液中。然後該5公升燒瓶中的溫度在122℃維持1小時。 A 5 liter flask was equipped with a stirrer, reflux condenser, thermocouple, heating bag, and nitrogen blanket. An example of the dissolved polyester solution (1782.0 g) and butyl glycol (123.0 g) as described above were placed in the 5 liter flask and preheated to 120°C under a nitrogen blanket. In another flask, premix 321.0 g of ethyl acrylate, 68.3 g of glacial acrylic acid, 96.1 g of styrene, and 11.9 g of VAZO 67 free radical initiator (2,2′-azobis(2-methylbutyl Nitrile), purchased from Du Pont de Nemours, Wilmington, Dalawa, USA). The mixture of the monomer and the initiator was added to the polyester solution at a temperature of 120°C to 122°C under a nitrogen blanket over a period of 135 minutes. The temperature in the 5 liter flask was then maintained at 122°C for 1 hour.
在此之後,加入2.6公克的TRIGONOX C自由基引發劑(叔丁基過氧化苯甲酸酯,購自Akzo Nobel公司)至該5公升燒瓶中,且反應器溫度在122℃下維持2小時。該反應溫度然後被冷卻至105℃,且在10分鐘的期間內將含有150.3公克的二甲基乙醇胺與150.3公克的去離子水的預混物加入該5公升燒瓶中,接著靜置10分鐘。在添加結束時,該反應混合物的溫度降至90℃。最後,在30分鐘的期間內加入2554克的水至該5公升燒瓶中,且聚酯丙烯酸酯溶液轉化為聚酯丙烯酸酯的水分散體。 After this, 2.6 g of TRIGONOX C radical initiator (tert-butyl peroxybenzoate, purchased from Akzo Nobel) was added to the 5 liter flask, and the reactor temperature was maintained at 122°C for 2 hours. The reaction temperature was then cooled to 105°C, and a premix containing 150.3 g of dimethylethanolamine and 150.3 g of deionized water was added to the 5 liter flask over a period of 10 minutes, followed by standing for 10 minutes. At the end of the addition, the temperature of the reaction mixture dropped to 90°C. Finally, 2554 grams of water was added to the 5 liter flask over a period of 30 minutes, and the polyester acrylate solution was converted into an aqueous dispersion of polyester acrylate.
將一60% VARCUM 2227酚醛樹脂溶液(211公克)(Reichhold 公司,德罕市,美國)併入該在最終水加入該聚酯丙烯酸酯樹脂的步驟完成後溫度約為60℃之轉化的聚酯丙烯酸酯樹脂中。在靜置20分鐘後添加此一VARCUM 2227樹脂。 Mix a 60% VARCUM 2227 phenolic resin solution (211 g) (Reichhold Company, Durham City, USA) incorporated into the converted polyester acrylate resin at a temperature of about 60°C after the final water addition step of the polyester acrylate resin is completed. Add this VARCUM 2227 resin after standing for 20 minutes.
聚酯丙烯酸酯酚醛的水分散體含有29.8重量百分比的固體(非揮發性物質),基於該聚酯丙烯酸酯酚醛的水分散體的總重量,係透過在150℃的溫度下加熱1公克的該聚酯丙烯酸酯酚醛的水分散體的樣本60分鐘而測得。該聚酯丙烯酸酯酚醛的水分散體在20℃的溫度下具有8.53標準pH單位的pH值。 The aqueous dispersion of polyester acrylate phenolic contains 29.8% by weight of solids (non-volatile matter). Based on the total weight of the polyester acrylate phenolic aqueous dispersion, it is obtained by heating 1 gram of this at 150°C. A sample of an aqueous dispersion of polyester acrylate phenolic resin was measured at 60 minutes. The aqueous dispersion of polyester acrylate phenolic resin has a pH value of 8.53 standard pH units at a temperature of 20°C.
將以上述方法製備之70.43份的聚酯丙烯酸酯酚醛樹脂在攪拌下,加入14.40份的去離子水以及由0.022份的CYCAT 600芳香族磺酸、10.75份的叔丁醇以及2.57份的CYMEL 303六甲氧基甲基三聚氰胺組成的預混物。得到的組合物在攪拌下加入0.17份的巴西棕櫚蠟乳液以及0.65份的BACOTE 20 AZC(MEL化學公司,曼徹斯特,英國;在水中稀釋至10%)。得到的產物適合用於噴塗在飲料罐頭的內部且在高溫下交聯。 70.43 parts of polyester acrylate phenolic resin prepared by the above method was added with stirring, 14.40 parts of deionized water and 0.022 parts of CYCAT 600 aromatic sulfonic acid, 10.75 parts of tert-butanol and 2.57 parts of CYMEL 303 A premix consisting of hexamethoxymethyl melamine. The resulting composition was added with stirring 0.17 parts of carnauba wax emulsion and 0.65 parts of BACOTE 20 AZC (MEL Chemical Company, Manchester, United Kingdom; diluted to 10% in water). The resulting product is suitable for spraying inside beverage cans and is cross-linked at high temperatures.
然而,在以下的實施例中,使用Valspar 40Q60AA(購自The Valspar公司,明尼亞波利斯,美國)作為不含雙酚A的含聚酯丙烯酸酯層(內襯A)。為了說明本發明的效用,製備該不含雙酚A的含聚酯丙烯酸酯層時不添加白藜蘆醇,或直接添加0.001重量百分比、0.01重量百分比,以及0.1重量百分比的白藜蘆醇至該適用於噴塗的溶液中。 However, in the following examples, Valspar 40Q60AA (available from The Valspar Company, Minneapolis, United States) was used as the bisphenol A-free polyester acrylate-containing layer ( liner A ). To illustrate the utility of the present invention, the preparation of the bisphenol A-free polyester acrylate-containing layer does not add resveratrol, or directly add 0.001 weight percent, 0.01 weight percent, and 0.1 weight percent resveratrol to This is suitable for spraying solutions.
含有環氧樹脂-丙烯酸酯層(根據PCT專利公開號WO 2008036629 A2的實施例18所製備)Contains epoxy resin-acrylate layer (prepared according to Example 18 of PCT Patent Publication No. WO 2008036629 A2)
一5公升的燒瓶配備有一攪拌器、回流冷凝器、熱電偶、加熱包以及氮氣層。在該反應器中加入低分子量的液體環氧樹脂與雙酚A以及丁基三苯基溴化鏻催化劑與二甲苯。在一開始便進行充氮及加熱,其後一放熱反應提高反應器內的溫度。 A 5 liter flask was equipped with a stirrer, reflux condenser, thermocouple, heating bag, and nitrogen blanket. In the reactor, low-molecular-weight liquid epoxy resin and bisphenol A and butyltriphenylphosphonium bromide catalyst and xylene were added. Nitrogen charging and heating were performed at the beginning, and then an exothermic reaction increased the temperature in the reactor.
在典型的6小時反應時間中達到每個環氧值約2900-3100的目標重量。然後在90分鐘的期間內緩慢加入丁基乙二醇、正丁醇以及戊醇溶劑。然後將丙烯酸單體苯乙烯與甲基丙烯酸加上過氧化苯甲醯引發劑LUCIDOL 78(購自Akzo Nobel公司,阿姆斯特丹,荷蘭)加至單體添加罐中。攪拌後,檢查此一單體/催化劑預混物的酸值。該單體/催化劑隨後被緩慢地加至該熱環氧溶液中,且進行丙烯酸聚合作用。接著冷卻該環氧樹脂丙烯酸溶液,並自該反應器移至一含有水及二胺基乙醇胺的溶液的薄罐中。透過轉化作用,該環氧樹脂丙烯酸溶液在經倒置水中形成分散體。 A target weight of about 2900-3100 per epoxy value is achieved in a typical 6 hour reaction time. Then butyl glycol, n-butanol and amyl alcohol solvents were slowly added over a period of 90 minutes. The acrylic monomer styrene and methacrylic acid plus benzoyl peroxide initiator LUCIDOL 78 (available from Akzo Nobel, Amsterdam, Netherlands) were then added to the monomer addition tank. After stirring, check the acid value of this monomer/catalyst premix. The monomer/catalyst is then slowly added to the hot epoxy solution, and acrylic acid polymerization is performed. The epoxy resin acrylic solution was then cooled and moved from the reactor to a thin tank containing a solution of water and diaminoethanolamine. Through conversion, the epoxy resin acrylic solution forms a dispersion in inverted water.
將以上述方法製備之76.02份的環氧樹脂丙烯酸樹脂分散體在攪拌下,加入18.82份的去離子水、3.68份的叔丁醇,以及由0.25份的二甲基胺基乙醇與1.23份的去離子水組成的預混物。得到的產物適合用於噴塗在飲料罐頭的內部且在高溫下交聯。 Under stirring, 76.02 parts of the epoxy resin acrylic resin dispersion prepared by the above method was added with 18.82 parts of deionized water, 3.68 parts of tert-butanol, and 0.25 parts of dimethylaminoethanol and 1.23 parts of A premix consisting of deionized water. The resulting product is suitable for spraying inside beverage cans and is cross-linked at high temperatures.
然而,在以下的實施例中,使用Aqualure 900(購自Akzo Nobel公司,阿姆斯特丹,荷蘭)作為該含有環氧樹脂-丙烯酸酯層(內襯B)。為了說明本發明的效用,製備該含有環氧樹脂-丙烯酸酯層時不添加白藜蘆醇,或直接添加0.001重量百分比、0.01重量百分比,以及0.1重量百分比的白藜蘆醇至該適用於噴塗的溶液中。 However, in the following examples, Aquaure 900 (available from Akzo Nobel Company, Amsterdam, Netherlands) is used as the epoxy resin-acrylate-containing layer ( inner liner B ). To illustrate the utility of the present invention, resveratrol was not added when preparing the epoxy resin-acrylate-containing layer, or 0.001 weight percent, 0.01 weight percent, and 0.1 weight percent resveratrol were directly added to this suitable for spraying In solution.
實施例2 Example 2
含有白藜蘆醇的塗覆層塗布至包裝材料/容器壁(在該容器成形之前/之後) A coating layer containing resveratrol is applied to the packaging material/container wall (before/after the container is formed)
透過使用雙頭噴槍以塗覆罐頭的內壁及圓頂,而將如實施例1所述之漆塗布於該鋁罐以作為一塗覆層。用於塗布的漆之用量視該被塗覆的罐頭之尺寸而定。在本實施例中,具有150至440毫升的體積的罐頭使用了100至240毫克的含有0.01重量百分比白藜蘆醇的內襯A或內襯B塗覆。 By using a double-headed spray gun to coat the inner wall and dome of the can, the aluminum can as described in Example 1 was applied as a coating layer. The amount of paint used for coating depends on the size of the coated can. In this example, cans having a volume of 150 to 440 ml were coated with 100 to 240 mg of Liner A or Liner B containing 0.01% by weight of resveratrol.
未固化的塗覆層在烘烤溫度介於180至250℃之間固化80至230秒。得到之該層的分佈厚度介於3.5至8.4公克每平方公尺(grams per square meter,gsm)。表1顯示在一塗覆含有0.01重量百分比白藜蘆醇的內襯A的罐頭的頂部、中段、底部與圓頂部分的該膜層的厚度。 The uncured coating layer is cured at a baking temperature between 180 and 250°C for 80 to 230 seconds. The resulting distribution thickness of the layer is between 3.5 and 8.4 grams per square meter (gsm). Table 1 shows the thickness of the film layer on the top, middle, bottom and dome portions of a can coated with a liner A containing 0.01% by weight of resveratrol.
實施例3 Example 3
塗覆罐的物理參數之評估 Evaluation of the physical parameters of the coating tank
檢驗實施例2中得到之罐頭的塗覆層的密合性(AS 1580方法408.4)、在18焦耳下的耐衝擊性(AS 1580方法406.1)、以鹽酸浸泡5分鐘後穿 孔度(SSL測試方法)。進一步以顯微鏡檢查這些罐頭是否起泡(AS 1580方法481.1.9)、分層(AS 1580方法481.1.10)以及腐蝕(AS 1580方法481.3)。該罐頭在所有測試中的性能皆優秀且維持該塗覆層的完整性。這些測試的結果如表2所示。 The adhesion of the coating layer of the can obtained in Example 2 (AS 1580 method 408.4), impact resistance at 18 Joules (AS 1580 method 406.1), immersion in hydrochloric acid for 5 minutes and wear Porosity (SSL test method). Further examination of these cans with a microscope for blistering (AS 1580 method 481.1.9), delamination (AS 1580 method 481.1.10) and corrosion (AS 1580 method 481.3). The performance of the can was excellent in all tests and maintained the integrity of the coating. The results of these tests are shown in Table 2.
實施例4 Example 4
包裝紅葡萄酒的感官評估 Sensory evaluation of packaged red wine
將紅葡萄酒包裝於獲自實施例2的250毫升的超薄罐頭內,然後儲存24個月。於試驗起始、3個月後、6個月後、12個月後以及24個月後分別進行感官評估。本實施例的結果如表3所示。 The red wine was packaged in 250 ml ultra-thin cans obtained from Example 2, and then stored for 24 months. Sensory evaluation was performed at the beginning of the trial, after 3 months, after 6 months, after 12 months, and after 24 months. The results of this example are shown in Table 3.
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