TWI653065B - 尼古丁粉末吸入器、及將尼古丁吸入至一用戶之肺中的方法 - Google Patents
尼古丁粉末吸入器、及將尼古丁吸入至一用戶之肺中的方法 Download PDFInfo
- Publication number
- TWI653065B TWI653065B TW104113148A TW104113148A TWI653065B TW I653065 B TWI653065 B TW I653065B TW 104113148 A TW104113148 A TW 104113148A TW 104113148 A TW104113148 A TW 104113148A TW I653065 B TWI653065 B TW I653065B
- Authority
- TW
- Taiwan
- Prior art keywords
- nicotine
- nicotine powder
- powder inhaler
- airflow
- powder
- Prior art date
Links
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title claims abstract description 144
- 239000000843 powder Substances 0.000 title claims abstract description 139
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 title claims abstract description 138
- 229960002715 nicotine Drugs 0.000 title claims abstract description 136
- 210000004072 lung Anatomy 0.000 title claims description 19
- 238000000034 method Methods 0.000 title claims description 4
- 239000002775 capsule Substances 0.000 claims description 28
- 239000013543 active substance Substances 0.000 claims description 13
- 239000002245 particle Substances 0.000 claims description 13
- SKZDZXPBBYUFBY-WLHGVMLRSA-N (e)-but-2-enedioic acid;3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound OC(=O)\C=C\C(O)=O.CN1CCCC1C1=CC=CN=C1 SKZDZXPBBYUFBY-WLHGVMLRSA-N 0.000 claims description 3
- AIBWPBUAKCMKNS-PPHPATTJSA-N 2-hydroxybenzoic acid;3-[(2s)-1-methylpyrrolidin-2-yl]pyridine Chemical compound OC(=O)C1=CC=CC=C1O.CN1CCC[C@H]1C1=CC=CN=C1 AIBWPBUAKCMKNS-PPHPATTJSA-N 0.000 claims description 3
- MMOPGICOOYBFJU-UHFFFAOYSA-N 3-(1-methylpyrrolidin-2-yl)pyridine;2-oxopropanoic acid Chemical compound CC(=O)C(O)=O.CN1CCCC1C1=CC=CN=C1 MMOPGICOOYBFJU-UHFFFAOYSA-N 0.000 claims description 3
- HDJBTCAJIMNXEW-PPHPATTJSA-N 3-[(2s)-1-methylpyrrolidin-2-yl]pyridine;hydrochloride Chemical compound Cl.CN1CCC[C@H]1C1=CC=CN=C1 HDJBTCAJIMNXEW-PPHPATTJSA-N 0.000 claims description 2
- 230000000391 smoking effect Effects 0.000 abstract description 11
- 239000004480 active ingredient Substances 0.000 description 11
- 235000019504 cigarettes Nutrition 0.000 description 6
- 239000008186 active pharmaceutical agent Substances 0.000 description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- FFYVQVZXWDGRAY-UHFFFAOYSA-N 3-(1-methylpyrrolidin-2-yl)pyridine;hydrate Chemical compound O.CN1CCCC1C1=CC=CN=C1 FFYVQVZXWDGRAY-UHFFFAOYSA-N 0.000 description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 229960003136 leucine Drugs 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 239000000779 smoke Substances 0.000 description 2
- 238000009423 ventilation Methods 0.000 description 2
- RFEJUZJILGIRHQ-OMDKHLBYSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;3-[(2s)-1-methylpyrrolidin-2-yl]pyridine Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.CN1CCC[C@H]1C1=CC=CN=C1 RFEJUZJILGIRHQ-OMDKHLBYSA-N 0.000 description 1
- GKTOAHZEMRRUKF-HVDRVSQOSA-N (2s)-2-aminopentanedioic acid;3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound OC(=O)[C@@H](N)CCC(O)=O.CN1CCCC1C1=CC=CN=C1 GKTOAHZEMRRUKF-HVDRVSQOSA-N 0.000 description 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
- 235000019454 L-leucine Nutrition 0.000 description 1
- 239000004395 L-leucine Substances 0.000 description 1
- 125000003440 L-leucyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C(C([H])([H])[H])([H])C([H])([H])[H] 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 230000001760 anti-analgesic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 229940125716 antipyretic agent Drugs 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 229940112141 dry powder inhaler Drugs 0.000 description 1
- 239000003571 electronic cigarette Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 210000001533 respiratory mucosa Anatomy 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000003566 sealing material Substances 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
- A24F42/60—Constructional details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/06—Inhaling appliances shaped like cigars, cigarettes or pipes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
- A24F42/20—Devices without heating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0003—Details of inhalators; Constructional features thereof with means for dispensing more than one drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
- A61M15/0006—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means
- A61M15/0008—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means rotating by airflow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0035—Piercing means
- A61M15/0036—Piercing means hollow piercing means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461984967P | 2014-04-28 | 2014-04-28 | |
| EP14166205 | 2014-04-28 | ||
| US61/984,967 | 2014-04-28 | ||
| ??14166205.6 | 2014-04-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201601780A TW201601780A (zh) | 2016-01-16 |
| TWI653065B true TWI653065B (zh) | 2019-03-11 |
Family
ID=50588559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW104113148A TWI653065B (zh) | 2014-04-28 | 2015-04-24 | 尼古丁粉末吸入器、及將尼古丁吸入至一用戶之肺中的方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US10932492B2 (enExample) |
| EP (1) | EP3136894B1 (enExample) |
| JP (1) | JP6712231B2 (enExample) |
| KR (1) | KR102428026B1 (enExample) |
| CN (1) | CN106163598B (enExample) |
| AU (1) | AU2015254993B2 (enExample) |
| CA (1) | CA2943459C (enExample) |
| ES (1) | ES2743898T3 (enExample) |
| HU (1) | HUE045841T2 (enExample) |
| MX (1) | MX381937B (enExample) |
| PL (1) | PL3136894T3 (enExample) |
| RU (1) | RU2696570C2 (enExample) |
| SG (1) | SG11201608974RA (enExample) |
| TW (1) | TWI653065B (enExample) |
| WO (1) | WO2015166344A1 (enExample) |
| ZA (1) | ZA201606073B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA122894C2 (uk) | 2014-04-28 | 2021-01-20 | Філіп Морріс Продактс С.А. | Інгалятор нікотинового порошку |
| CA2943459C (en) | 2014-04-28 | 2023-05-02 | Philip Morris Products S.A. | Nicotine powder inhaler |
| CN106170313B (zh) * | 2014-04-28 | 2020-11-10 | 菲利普莫里斯生产公司 | 带香味尼古丁粉末吸入器 |
| US9968125B2 (en) | 2015-01-09 | 2018-05-15 | Philip Morris Products S.A. | Nicotine—diketopiperazine microparticle formulations and methods of making the same |
| EP3283151B1 (en) * | 2015-04-15 | 2022-07-20 | Philip Morris Products S.A. | Dry powder inhaler and method of use |
| JP7189765B2 (ja) * | 2015-04-15 | 2022-12-14 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 吸入装置のための香味要素 |
| US9585835B1 (en) | 2015-09-16 | 2017-03-07 | Sansa Corporation (Barbados) Inc. | Inhalable nicotine formulations and methods of making and using the same |
| US10149844B2 (en) | 2015-09-16 | 2018-12-11 | Philip Morris Products S.A. | Inhalable nicotine formulations, and methods of making and using thereof |
| US20170071248A1 (en) | 2015-09-16 | 2017-03-16 | Sansa Corporation (Barbados) Inc. | System and Method for Controlling the Harshness of Nicotine-Based Dry Powder Formulations |
| US11224594B2 (en) | 2015-09-16 | 2022-01-18 | Philip Morris Products S.A. | Nicotine formulations and methods of making and using the same |
| UA123586C2 (uk) * | 2015-12-24 | 2021-04-28 | Філіп Морріс Продактс С.А. | Капсула із частинками нікотину |
| MY186270A (en) | 2015-12-24 | 2021-07-01 | Philip Morris Products Sa | Flavoured nicotine powder |
| KR102649827B1 (ko) * | 2015-12-24 | 2024-03-21 | 필립모리스 프로덕츠 에스.에이. | 니코틴 분말 전달 시스템 |
| MX2019009866A (es) | 2017-02-28 | 2019-12-02 | Philip Morris Products Sa | Dispositivo generador de aerosol que comprende un accionador desaglomerante en polvo. |
| GB2604314A (en) * | 2017-09-22 | 2022-09-07 | Nerudia Ltd | Device, system and method |
| BR112021015029A2 (pt) * | 2019-03-05 | 2021-10-05 | Philip Morris Products S.A. | Dispositivo de perfuração para artigo de inalador |
| US12082611B2 (en) | 2019-05-24 | 2024-09-10 | Imperial Tobacco Limited | Aerosol delivery device |
| EP3741235A1 (en) * | 2019-05-24 | 2020-11-25 | Nerudia Limited | Aerosol delivery device |
| WO2022018301A1 (en) | 2020-07-24 | 2022-01-27 | Philip Morris Products S.A. | Inhaler article |
| JP2026509961A (ja) * | 2022-10-27 | 2026-03-26 | ケーティー アンド ジー コーポレイション | 咳の抑制剤を含有する乾燥粉末吸入器用スティック及びそれを含む乾燥粉末吸入器 |
| KR102824242B1 (ko) * | 2022-11-02 | 2025-06-25 | 주식회사 케이티앤지 | 흡입기 |
| CN116183430B (zh) * | 2022-12-30 | 2026-03-10 | 深圳市吉迩科技有限公司 | 尼古丁的测定系统、方法、装置、计算机设备及存储介质 |
| KR20240162737A (ko) * | 2023-05-09 | 2024-11-18 | 주식회사 케이티앤지 | 파우더 카트리지를 포함하는 흡입기 |
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| US4735217A (en) | 1986-08-21 | 1988-04-05 | The Procter & Gamble Company | Dosing device to provide vaporized medicament to the lungs as a fine aerosol |
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| US4655229A (en) * | 1984-01-30 | 1987-04-07 | R. J. Reynolds Tobacco Company | Flavor delivery system |
| US4597961A (en) * | 1985-01-23 | 1986-07-01 | Etscorn Frank T | Transcutaneous application of nicotine |
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| JP6050758B2 (ja) * | 2010-12-07 | 2016-12-21 | レスピラ セラピューティクス インコーポレイテッドＲｅｓｐｉｒａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 乾燥粉末吸入器及びその作動方法 |
| GB2497616A (en) | 2011-12-13 | 2013-06-19 | Cn Creative Ltd | Flavoured inhalation device |
| US10549052B2 (en) | 2012-02-28 | 2020-02-04 | Sipnose Ltd. | Nasal delivery device |
| MX2014015741A (es) * | 2012-07-05 | 2015-08-06 | Glaxo Group Ltd | Dispositivo inhalador. |
| US20140088044A1 (en) * | 2012-09-21 | 2014-03-27 | Basil Rigas | Product comprising a nicotine-containing material and an anti-cancer agent |
| CN103566444B (zh) | 2013-11-12 | 2015-04-15 | 江苏大学 | 一种医用盐雾测控仪及盐雾浓度定量控制方法 |
| CN106170313B (zh) * | 2014-04-28 | 2020-11-10 | 菲利普莫里斯生产公司 | 带香味尼古丁粉末吸入器 |
| CA2943459C (en) | 2014-04-28 | 2023-05-02 | Philip Morris Products S.A. | Nicotine powder inhaler |
-
2015
- 2015-04-23 CA CA2943459A patent/CA2943459C/en active Active
- 2015-04-23 HU HUE15751065A patent/HUE045841T2/hu unknown
- 2015-04-23 KR KR1020167027861A patent/KR102428026B1/ko active Active
- 2015-04-23 MX MX2016014089A patent/MX381937B/es unknown
- 2015-04-23 US US15/124,562 patent/US10932492B2/en active Active
- 2015-04-23 CN CN201580019505.5A patent/CN106163598B/zh active Active
- 2015-04-23 JP JP2016565018A patent/JP6712231B2/ja active Active
- 2015-04-23 PL PL15751065T patent/PL3136894T3/pl unknown
- 2015-04-23 SG SG11201608974RA patent/SG11201608974RA/en unknown
- 2015-04-23 WO PCT/IB2015/000924 patent/WO2015166344A1/en not_active Ceased
- 2015-04-23 RU RU2016146351A patent/RU2696570C2/ru not_active Application Discontinuation
- 2015-04-23 EP EP15751065.2A patent/EP3136894B1/en active Active
- 2015-04-23 ES ES15751065T patent/ES2743898T3/es active Active
- 2015-04-23 AU AU2015254993A patent/AU2015254993B2/en active Active
- 2015-04-24 TW TW104113148A patent/TWI653065B/zh active
-
2016
- 2016-09-01 ZA ZA2016/06073A patent/ZA201606073B/en unknown
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2021
- 2021-02-05 US US17/168,417 patent/US11878114B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4735217A (en) | 1986-08-21 | 1988-04-05 | The Procter & Gamble Company | Dosing device to provide vaporized medicament to the lungs as a fine aerosol |
Also Published As
| Publication number | Publication date |
|---|---|
| US10932492B2 (en) | 2021-03-02 |
| TW201601780A (zh) | 2016-01-16 |
| HUE045841T2 (hu) | 2020-01-28 |
| SG11201608974RA (en) | 2016-11-29 |
| EP3136894A1 (en) | 2017-03-08 |
| EP3136894B1 (en) | 2019-07-31 |
| CA2943459C (en) | 2023-05-02 |
| JP2017513648A (ja) | 2017-06-01 |
| JP6712231B2 (ja) | 2020-06-17 |
| AU2015254993B2 (en) | 2019-04-11 |
| AU2015254993A1 (en) | 2016-09-15 |
| RU2696570C2 (ru) | 2019-08-06 |
| RU2016146351A3 (enExample) | 2019-03-15 |
| MX381937B (es) | 2025-03-13 |
| CN106163598A (zh) | 2016-11-23 |
| KR102428026B1 (ko) | 2022-08-03 |
| CA2943459A1 (en) | 2015-11-05 |
| RU2016146351A (ru) | 2018-05-29 |
| ES2743898T3 (es) | 2020-02-21 |
| KR20160148524A (ko) | 2016-12-26 |
| CN106163598B (zh) | 2020-11-10 |
| MX2016014089A (es) | 2017-02-09 |
| US20170035107A1 (en) | 2017-02-09 |
| US20210178092A1 (en) | 2021-06-17 |
| US11878114B2 (en) | 2024-01-23 |
| PL3136894T3 (pl) | 2020-02-28 |
| WO2015166344A1 (en) | 2015-11-05 |
| ZA201606073B (en) | 2017-11-29 |
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