TWI644686B - Oral poison adsorbent and preparation method thereof - Google Patents

Abstract

Oral poison adsorbent and preparation method thereof, which can be administered orally, and adsorb organic poison or inorganic poison, including: heavy metal, phosphorus and urinary toxin, etc., which affect liver and kidney function, and the oral poison adsorbent designed in the present case, Will not stick to the gastrointestinal tract and can be quickly excreted; the preparation steps include: placing a bamboo in a temperature of 400 ° C to 950 ° C, carbonizing the bamboo, and introducing an inert gas to avoid oxidation of the bamboo, followed by 750 An activator is introduced into the temperature from °C to 1000 °C to activate the bamboo material to produce an activated bamboo charcoal, and then the activated bamboo charcoal is ground to an appropriate size and mixed with a biodegradable polymer material to prepare the structure to be bio-available. The deuterated polymer material is coated with one of the activated carbon powder microspheres, and the active bamboo charcoal microsphere is an oral poison adsorbent.

Description

Oral poison adsorbent and preparation method thereof

The invention relates to an active bamboo charcoal microsphere with a porous structure, which can effectively adsorb the nephrotoxin in the digestive tract, and can quickly excrete the adsorbent through the gastrointestinal tract and the manufacturing method thereof.

Due to ageing, accidents, illnesses, occupational long-term exposure, environmental pollution and daily diet, kidney toxins and heavy metal ions enter the human body through the gastrointestinal tract, respiratory tract and skin, and are further bonded to the body's proteins. Until the kidney is filtered and removed, nephrotoxin and heavy metal ions are easily accumulated in the kidney glomerulus and renal tubules, causing kidney damage, thereby reducing renal function, and finally evolve into chronic kidney disease; patients with chronic kidney disease, after losing kidney function, the body The waste produced cannot be excreted from the body, gradually accumulates in the body, causing toxicity of various organs. Ultimately, it is necessary to metabolize the toxins in the body through dialysis. However, many kidney toxins are still exposed to the daily life of dialysis patients, including heavy metal ions and phosphoric acid. Salts and urinary toxins can cause further damage to the kidneys. Therefore, if an oral agent can be developed, the nephrotoxin can be excreted from the body, which will benefit the kidney patients and take care of the health of modern people.

Urotoxins, including medium molecular urinary toxins, low molecular urea toxins, and macromolecular toxins. The production of urinary toxins is mainly protein ingested by humans. After being metabolized by bacteria, it is converted into a precursor of urinary toxin, which is absorbed into the human body by the large intestine. After conversion to urinary toxins, the accumulation of urinary toxins in the body can cause chronic kidneys Dirty diseases, for patients with chronic kidney disease, the accumulation of urinary toxins in the body can cause cardiovascular disease, worsening chronic kidney disease and other complications; urinary toxins are indoxyl sulfate and contralateral P-cresol has been mentioned in many literatures, and its accumulation in the body causes many complications, indirectly worsening renal function and eventually becoming uremia.

Because patients with chronic kidney disease have limited ability to remove harmful substances from the body and have limited filtration capacity, the phosphate that enters the body through food cannot be cleared by the kidneys, resulting in the production of high blood phosphorus, which will further lead to hyperthyroidism and renal bone lesions.

At present, the most common way for toxic substances to be excreted in vitro is to perform hemodialysis, commonly known as "dialysis". By washing the kidneys, the urinary toxins and water are excreted to reduce the symptoms of uremia and stabilize the signs of life. Although hemodialysis has Good ability to filter waste, but it is not good for pro-protein urinary toxins, and hemodialysis relies on the professional skills of medical personnel in operation. Moreover, the dialysis process is lengthy and expensive, during and after dialysis treatment. There may be cramps, nausea, fatigue, etc. In addition, each treatment has blood loss or blood cell destruction, which is prone to anemia and other symptoms, resulting in physical and mental and economic stress.

In recent years, some people have been developing oral drugs for the absorption of toxins from chronic kidney patients. It is known that there are two kinds of oral adsorbents, the raw materials of which are mainly asphalt and plant carbon materials. When using asphalt to prepare oral adsorbents, the first need to remove them. The impurities and heavy metals are processed into spherical particles, which are complicated in preparation and high in cost, so they are expensive, and cause an economic burden on patients who need to take long-term use; and oral adsorbents prepared by plant carbon materials, The plant charcoal material is ground into a fine powder, which is difficult to be discharged by the gastrointestinal motility, and is easy to adhere to the intestinal wall, so that the oral drug adsorbing the poison has a longer residence time in the body, thereby stimulating the gastrointestinal tract, and is not conducive to Excretion of toxins.

For this reason, the Applicant has developed an oral toxic adsorbent that is orally administered into the body to adsorb heavy metals, urinary toxins, and phosphorus, and which has good adsorptivity and is rapidly excreted from the body, in order to solve the current problem, in view of the lack of the prior art.

The object of the present invention is to provide an oral toxicant adsorbent which can be administered orally to enter the gastrointestinal tract to adsorb organic or inorganic toxicants, including: heavy metals, phosphorus, urinary toxins, molecules affecting liver and kidney function, poisons ingested or caused Pathogens, etc., and can be quickly excreted from the body, not sticky in the gastrointestinal tract; thus, not only can be used for the elimination of toxic substances in the daily life of healthy people and patients with chronic kidney disease, but also can be applied to emergency treatment drugs for patients with chemical poisoning. Slow down the spread of poisons in the body.

In order to achieve the above object, the present invention selects a porous and adsorbable bamboo charcoal for the manufacture of an oral adsorbent, which is prepared by first cutting a bamboo material, cleaning it, and placing it in a high temperature carbonization furnace; The carbonization furnace is heated to 400 ° C to 950 ° C to carry out a carbonization process; then, the temperature is maintained at 750 ° C to 1000 ° C in the high temperature carbonization furnace to activate bamboo charcoal to produce an activated bamboo charcoal; the activated bamboo charcoal is cooled and cleaned. Drying the activated bamboo charcoal into an active bamboo charcoal powder, and then mixing the active bamboo charcoal powder with a biodegradable polymer material, further dropping the active bamboo charcoal powder mixed with the biodegradable polymer material 0.01-10% of the cross-linking solution, that is, the active bamboo charcoal microsphere prepared by coating the bio-deuterated polymer material with a plurality of active bamboo charcoal powder, the active bamboo charcoal microsphere is the oral poison adsorbent of the invention .

Another object of the present invention is to avoid the phenomenon that the conventional oral drug is adhered in the gastrointestinal tract, and the active bamboo charcoal powder is mixed with the natural high molecular substance of the biodegradable polymer material in the process, thereby adsorbing the oral poison of the nephrotoxin. The adsorbent can quickly pass through the gastrointestinal tract and excrete from the body, avoiding the intestines The gastric tract is sticky, and the surface of the biodegradable polymer material has a plurality of pores, which can enhance the adsorption capacity of the oral toxic adsorbent.

501‧‧‧Bamboo

502‧‧‧ cleaning solution

503‧‧‧Carbonized bamboo

505‧‧‧Active bamboo charcoal

507‧‧‧Active bamboo charcoal powder

509‧‧‧Active bamboo charcoal microspheres

509’‧‧‧正电竹炭微球

509”‧‧‧negative bamboo charcoal microspheres

101‧‧‧High temperature carbonization furnace

102‧‧‧Bio-degradable polymer materials material

105‧‧‧activator

103‧‧‧Inert gas

107‧‧‧Abrasive components

S1~S6‧‧‧Steps

T‧‧‧ kidney toxin

B1‧‧‧ oral buffer solution

B2‧‧‧ gastric juice buffer solution

B3‧‧‧Intestinal buffer solution

B4‧‧‧ Large Intestine Buffer Solution

Figure 1 is a flow chart of a process block of the present invention.

Figure 2 is a schematic cross-sectional view of the present invention.

Figure 3 is a scanning electron microscope (SEM) image (27x) of the present invention.

Figure 4 is a scanning electron microscope (SEM) image (350x) of the present invention.

Figure 5 is a comparison diagram of X-ray diffraction of the present invention.

Fig. 6 is a view showing the results of the adsorption capacity of the methylene blue aqueous solution of the present invention.

Figure 7 is a schematic view showing the results of the adsorption capacity of the aqueous solution of iodine according to the present invention.

Figure 8 is an electron microscope (SEM) image (30X) of a positively charged bamboo charcoal microsphere of the present invention.

Figure 9 is an electron microscope (SEM) image (65X) of a negatively charged bamboo charcoal microsphere of the present invention.

Figure 10 is a schematic flow chart of Embodiment 3 of the present invention.

Fig. 11A is a graph showing the results of adsorption of heavy metal lead in Example 3 of the present invention.

Fig. 11B is a graph showing the results of adsorption of heavy metal chromium according to Example 3 of the present invention.

Fig. 11C is a graph showing the results of phosphate adsorption of Example 3 of the present invention.

Fig. 11D is a view showing the adsorption of urinary toxin oxime in Example 3 of the present invention.

Fig. 11E is a graph showing the results of adsorption of urinary toxin to cresol according to Example 3 of the present invention.

Referring to Figures 1 and 2, the present invention provides an oral poison adsorbent and a method for producing the same, which are carried out according to the following steps: First, a bamboo material 501 is cut into a size of about 10 cm × 5 cm, cleaned and placed. In a high temperature carbonization furnace 101, step S1 is performed, vacuum evacuation; then step S2 is performed, and the temperature of the high temperature carbonization furnace 101 is raised to 400 ° C to 950 ° C at a temperature increase rate of 5-20 ° C / min, wherein 600 ° C to 600 ° C 900 ° C is the best, the cut bamboo 501 is placed therein for 30 to 60 minutes, the bamboo 501 is carbonized, and an inert gas 103 is introduced into the high temperature carbonization at a speed of 100 ml/min to 400 ml/min during the heating process. In the furnace 101, wherein the speed is preferably 100 ml/min, the inert gas 103 may be nitrogen or argon, and the bamboo 501 is burned and carbonized in an oxygen-free environment to produce a carbonized bamboo 503; then, step S3 is performed. The carbonized bamboo 503 is continuously maintained at 750 ° C to 1000 ° C, at an optimum temperature of 900 ° C, and an activator 105 is introduced at a rate of 100 ml / min to 400 ml / min to activate bamboo charcoal. The activator 105 can be carbon dioxide or steamed The inlet speed is preferably 100 ml/min, and the action time is 1 to 2 hours, so that an activated bamboo charcoal 505 is produced; then, in step S4, the activated bamboo charcoal 505 is cooled, and the cleaning liquid is cleaned with a cleaning liquid 502. Drying; performing step S5, grinding the active bamboo charcoal 505 into an appropriate size by using a grinding element 107, wherein the grinding element 107 is preferably 100-230 mesh, and sorting one of 50 micrometers to 1000 micrometers of activated bamboo charcoal powder 507 In step S6, the activated bamboo charcoal powder 507 after grinding is mixed with a biodegradable polymer material 102 in a weight ratio of 1:2 to 1:5, preferably 1:3, by stirring. The activated carbon powder 507 is uniformly dispersed in the biodegradable polymer material 102, and the active bamboo charcoal powder 507 mixed with the biodegradable polymer material 102 is further dropped into 0.01-10% of a crosslinking solution, and the present invention The cross-linking solution is a 1M NaOH solution, that is, the active bamboo charcoal microsphere 509 is prepared by coating the bio-deuterated polymer material 102 with a plurality of active bamboo charcoal powder 507. 509 is the oral toxic adsorbent of the present invention, and the active bamboo charcoal microsphere 509 has a diameter of about 100 micrometers to 2000 micrometers (see Fig. 2).

In the above process step, the bamboo material 501 may be a group of any kind of bamboo such as Mengzong bamboo, phoenix bamboo or light bamboo of the mature group, and the invention is selected from Mengzong bamboo material of four or more years; the cleaning liquid 502 may be an acidic aqueous solution or an alkaline aqueous solution. And an organic solvent or the like; the biodegradable polymer material 102 can be: 1% to 3% (w/v) chitosan (chitosan), corn starch, methyl cellulose, gelatin, alginate, poly Any group of single or arbitrary components such as dextrin and alginate, such as natural polymers, natural polymer improvements, and any synthetic polymers.

Referring to Figures 3 and 4, the active bamboo charcoal microspheres 509 of the present invention are spherical, and the surface topography of the active bamboo charcoal microspheres 509 is detected by SEM. The SEM image (27x) shows the active bamboo charcoal microspheres 509. The appearance is a complete spherical shape with a rough surface, the size is about 1.5 mm, and the surface presents irregular rough holes. The active bamboo charcoal microspheres 509 are cut open, and the SEM image shows (350x) that the inside of the active bamboo charcoal microspheres 509 is A porous, spongy structure (see Figure 4).

The active bamboo charcoal microsphere 509 can pass through the esophagus and can be orally administered into the gastrointestinal tract, and has the characteristics of adsorbing organic or inorganic toxicity in the body, and the organic or inorganic toxicity includes heavy metals, phosphorus, chemicals, and bacterial viruses. , digestive toxins, other organic wastes, objects trapped in the intestines, physiological metabolites, molecules affecting liver and kidney function, and poisons or pathogens that are inadvertently eaten, the active bamboo charcoal microspheres 509 can absorb the above substances and pass through the stomach The motility is excreted from the body.

The specific surface area analyzer (BET) was used to measure the difference in specific surface area before and after activation of bamboo charcoal. As shown in Table 1, the specific surface area of bamboo charcoal (ie, charred bamboo 503) before activation was 195.82±11.5 m ² /g, when the charred bamboo 503 was in At 900 ° C, after activation with the activator 105, the specific surface area was increased by 2.7 times to 534.39 ± 32.5 m ² /g.

Referring to Figure 5, X-ray diffraction (XRD) is used to observe the activated bamboo charcoal 505 (see Figure 5A) and the unactivated bamboo carbon (see Figure 5B). Compared with the unactivated bamboo charcoal, the active bamboo charcoal 505 has no change in crystal structure, microstructure and porosity, and the activated bamboo charcoal 505 has high porosity and high adsorption force compared with the unactivated bamboo charcoal. The surface has a functional group (see Annex 1), which has a good effect on the adsorption of nephrotoxin.

The inventors performed the adsorption capacity test on the active bamboo charcoal microspheres 509, such as methylene blue, iodine, metal ions, phosphate, and urinary toxin.

Example 1

Referring to FIG. 6 , in this embodiment, the adsorption test of the methylene blue aqueous solution of the oral poison adsorbent is performed by first disposing a methylene blue aqueous solution having a concentration of 20 ppm, 10 mg of the active bamboo charcoal microsphere 509, unactivated carbonized bamboo 503, and the city. The commercially available oral adsorbent (control group) was immersed in a methylene blue aqueous solution for 24 hours, and then the change in the concentration of the methylene blue aqueous solution was measured using a spectrophotometer; after 24 hours, the active bamboo charcoal microsphere 509 of the present invention was found to have a good adsorption capacity for methylene blue. .

Example 2

Referring to FIG. 7 , in this embodiment, the iodine adsorption test of the oral toxic adsorbent is performed, and the adsorption of activated carbon on iodine is measured according to the Japanese Industrial Standard JISK1474 (19991). Active bamboo charcoal microspheres 509, unactivated charred bamboo 503 and commercially available mouth The adsorbent (control group) was added to the standard aqueous iodine solution for testing, and the amount of iodine adsorbed by the active bamboo charcoal microsphere 509 was measured; the results showed that all three groups had good adsorption effects.

It can be seen from Examples 1 and 2 that the present invention has an adsorption effect comparable to that of a commercially available oral adsorbent, and even has a better adsorption force.

Example 3, 4

Referring to Figures 8 and 9, in the Examples 3 and 4, the active bamboo charcoal powder 507 is coated with the biodegradable polymer material 102 to simulate the adsorption capacity of the gastrointestinal environment to the nephrotoxin. The nephrotoxin includes: lead (Pb), chromium (Cr), phosphate (PO ₄ ^3- ), indole, and p-cresol; firstly, the active bamboo charcoal powder 507 is separately mixed and added. Chitosan's biodegradable polymer material 102 forms a positively charged positive charcoal microsphere 509' (see Figure 8), and the addition of alginate to the organism. The deuterated polymer material 102 forms a negatively charged negatively charged bamboo charcoal microsphere 509" (see Figure 9). It can be found from Figures 8 and 9 that the biodegradable polymer material 102 is coated differently. The active bamboo charcoal microspheres 509 are still round in shape and have a porous surface morphology. The biodegradable polymer material 102 is added with chitosan and alginic acid to make the active bamboo charcoal microspheres 509 The surface has different functional groups; the bio-deuterated polymer material 102 of the chitosan is the positive electric bamboo charcoal micro 509 'having a surface with NH ₃ ⁺ functional groups can be combined with negatively charged ions of (e.g., phosphorus ions), followed by the formation of crystalline after recombined with positively charged ions of (e.g., calcium), and excreted through the gastrointestinal tract motility; Further, the negatively-charged bamboo charcoal microsphere 509" of the biodegradable polymer material 102 coated with alginic acid has a COO ^- functional group on its surface, first combined with positively charged ions (such as calcium ions), and then negatively charged. The ions (phosphorus ions) combine to form crystals further and are excreted through the gastrointestinal motility.

Example 3 - Nephrotoxin adsorption test 1

Referring to FIG. 10, first, 0.05 g of the positive and negative electric bamboo charcoal microspheres 509', 509" are respectively taken and immersed in an oral buffer solution B containing one nephrotoxin T for 15 minutes, and the oral buffer solution B1 is used. The pH is 6.5. After 5 minutes, the oral buffer solution B1 is taken to measure the absorbance, and the amount of the toxin T adsorbed in the oral buffer solution B1 is detected. Then, the gastric juice buffer solution B2 containing the nephrotoxin T is added to the above. In the positive and negative electric bamboo charcoal microspheres 509', 509", the gastric juice buffer solution B2 has a pH of 2, and after soaking for 2 hours, the gastric juice buffer solution B2 is taken out, and the absorbance value thereof is tested, and then the nephrotoxin T is contained. One small intestinal buffer solution B3 is added to the above-mentioned positive and negative electric bamboo charcoal microspheres 509', 509", the pH value of the small intestinal buffer solution B3 is 7.5, and after immersing for 5 hours, the small intestinal buffer solution B3 is taken out, and the absorbance is tested. Finally, the large intestine buffer solution B4 containing the nephrotoxin T is added to the positive and negative electric bamboo charcoal microspheres 509', 509", the pH value of the large intestine buffer solution B4 is 8, and the large intestine buffer is taken out after soaking for 24 hours. Solution B4, test its suction Value.

In the present embodiment, when testing uremic toxin-indole (p-Cresol), since urinary toxin only appears in the small intestine and the large intestine, 0.05 g of the positive and negative electric bamboo charcoal microspheres are first introduced. 509', 509" soak the oral buffer solution B for 15 minutes, remove the oral buffer solution B1 after 5 minutes, then add the gastric juice buffer solution B2 and soak for 2 hours, remove the gastric juice buffer solution B2 after 2 hours, and then add the kidney containing The intestinal buffer solution B3 of the toxin T is taken out for 5 hours, the small intestinal buffer solution B3 is taken out, the absorbance value thereof is tested, and finally the large intestine buffer solution B4 containing the nephrotoxin T is added to the positive and negative electric bamboo charcoal microspheres 509', 509. In the middle, after immersing for 24 hours, the large intestine buffer solution B4 was taken out and tested for absorbance.

Referring to Figures 11A-E, the abscissa is the result of the absorption of the nephrotoxin T by the positive and negative bamboo charcoal microspheres 509', 509" in different buffer solutions, and the ordinate is per gram (g). How many milligrams (mg) of the nephrotoxin T can be absorbed by the positive and negative bamboo charcoal microspheres 509', 509"; the attraction effect of heavy metal lead in the four buffers is statistically significant (see Figure 11A). , heavy metal chromium is small, The attracting effects of the large intestine buffers B3 and B4 are statistically significant (see Figure 11B). The attraction of phosphate in the oral and gastric buffers B1 and B2 is statistically significant (see Figure 11C). ), the attraction effects of the small and large intestine buffers B3 and B4 are statistically significant (see Figure 11D), and the attraction effects of p-cresol in the small and large intestine buffers B3 and B4 are statistically significant. The meaning (see Fig. 11E), in summary, the positive and negative bamboo charcoal microspheres 509', 509" have good absorption effects for various nephrotoxin T.

In order to achieve good adsorption of the rennet toxin T, the active bamboo charcoal microspheres 509 mixed with one or more of the biodegradable polymer materials 102 may be selected and used in combination, wherein the biodegradable acid may be deuterated. The negatively-charged bamboo charcoal microspheres 509 ′′ formed by the polymer material 102 and the positively-charged bamboo charcoal microspheres 509 ′ formed by the biodegradable polymer material 102 added with chitosan have a mixing ratio of 2:1. Up to 5:1, especially 3:1 is the best, which can improve the adsorption efficiency.

In summary, the active bamboo charcoal microspheres 509 can be administered orally into the gastrointestinal tract, because the active bamboo charcoal microspheres 509 have a plurality of pores, and because of activation, the surface has a plurality of functional groups, which can absorb toxic substances in the human body. Further, during the process, the active bamboo charcoal powder 507 is mixed with the different kinds of natural high molecular substances of the biodegradable polymer material 102, so that the active bamboo charcoal microspheres 509 can be quickly excreted through the gastrointestinal tract peristalsis. The raw material of the active bamboo charcoal microsphere 509 is bamboo, the raw material is easy to obtain, the process is simple, and the function of adsorbing the toxin of the gastrointestinal tract and the rapid excretion of the body is obtained; in contrast, the oral adsorption of the conventional method has a complicated process, is expensive, and is easy to adhere after oral administration. On the wall of the gastrointestinal tract, it is difficult to excrete the body by the peristalsis of the gastrointestinal tract.

The detailed description of the preferred embodiments of the present invention is not intended to limit the scope of the present invention, and the equivalent implementations or modifications of the present invention should be included in the present invention. In the scope of patents.

Claims (9)

The structure of an oral toxic adsorbent is characterized in that a bio-deuterated polymer material of a chitosan is coated with an active bamboo carbon powder to form a positively functional positively charged bamboo carbon microsphere structure with a surface functional group, wherein The mixed weight ratio of the active bamboo charcoal powder to the chitosan biodegradable polymer material is 1:2 to 1:5, and the toxic substances in the gastrointestinal tract are orally administered by the oral cavity, and then excreted from the intestinal tract. The structure of the oral poison adsorbent according to claim 1, wherein the positively-active bamboo carbon microsphere structure has a particle diameter of about 100 to 2000 μm. The structure of an oral poison adsorbent is a negatively active negatively active bamboo carbon microsphere structure formed by coating a living bamboo carbon powder with a biodegradable polymer material of alginic acid, wherein the active bamboo charcoal powder and the active bamboo charcoal powder The alginic acid biodegradable polymer material has a mixing ratio of 1:2 to 1:5, and the toxic substance of the gastrointestinal tract is orally administered, and then excreted from the intestine. The negatively active bamboo carbon microsphere structure has a particle size of about 100-2000 microns as claimed in claim 3 of the oral toxic adsorbent. The invention relates to a method for manufacturing an oral poison adsorbent, which comprises the steps of: cutting a bamboo material into a high-temperature carbonization furnace, evacuating the vacuum; placing the bamboo material in the high-temperature carbonization furnace, and heating the temperature to 400 ° C to 950 ° C The reaction is carried out for 30 minutes to 1 hour to carbonize the bamboo material, and an inert gas is introduced into the carbonization process to burn the bamboo material in an oxygen-free environment to produce a carbonized bamboo material; the carbonized bamboo material is continuously placed at the high temperature carbonization. In the furnace, the temperature of the high-temperature carbonization furnace is adjusted to be activated at 750 ° C to 1000 ° C, and an activator is introduced into the activation process for 1 to 2 hours to activate bamboo charcoal to produce an activated bamboo charcoal; Activate bamboo charcoal to cool, then use a cleaning solution and let it dry; Passing the activated bamboo charcoal through a grinding element to form an active bamboo charcoal powder of 50 micrometers to 1000 micrometers; and the weight ratio of the activated bamboo charcoal powder to the biodegradable polymer material after grinding is 1:2 to 1:5 Mixing; and the active bamboo charcoal powder mixed with the biodegradable polymer material is dropped into 0.01-10% of the crosslinking solution to prepare an active bamboo charcoal microsphere having a diameter of about 100 micrometers to 2000 micrometers, which is an oral poison Adsorbent. The method for producing an oral poison adsorbent according to claim 5, wherein the inert gas system is selected from any one of nitrogen gas and argon gas, and is introduced into the high temperature carbonization furnace at a rate of from 100 ml/min to 400 ml/min. The method for producing an oral poison adsorbent according to claim 5, wherein the activator is selected from any one of carbon dioxide or water vapor, and is introduced into the high temperature carbonization furnace at a rate of from 100 ml/min to 400 ml/min. The method for preparing an oral toxic adsorbent according to claim 5, wherein the biodegradable polymer material is selected from the group consisting of chitosan, alginic acid, corn starch, methyl cellulose, gelatin, alginate, and polydextrose. Any group of natural polymers, natural polymers, and any single or any combination of synthetic polymers. The method for preparing an oral toxic adsorbent according to claim 8 , wherein the biodegradable polymer material is alginic acid and chitosan, and the weight ratio of alginic acid or chitosan to bamboo charcoal powder is 2 : 1 to 5:1.