TWI640468B - Microfluidic device - Google Patents

Abstract

A microchannel device comprises a substrate, a feed chute, a first liquid separation unit, and a feed flow path. The substrate includes a top surface having a central region at the center and a first annular region surrounding the central region. The feed chute is formed in a central region of the top surface of the substrate. The first liquid separation unit is formed on the top surface of the substrate corresponding to the first annular region, and the first liquid separation unit includes a plurality of receiving groove groups arranged along the circumferential direction of the first annular region, and a connection Each of the accommodating groove groups has a metering groove and a working groove. The metering trough has an inflow end that communicates with the diverting channel and is the narrowest region of the metering trough. The feed channel communicates with the feed chute and the split channel of the first liquid separation unit.

Description

Microchannel device

The present invention relates to a microchannel device, and more particularly to a microchannel device suitable for dispensing liquid.

An existing micro-channel device for detecting a reaction state of a liquid test object and a different agent, the micro-channel device comprising a substrate, a feed groove formed on a top surface of the substrate, and a liquid separation unit formed on a top surface of the substrate and communicating with the feed tank. The liquid separation unit includes a flow dividing channel that communicates with the feed groove and is annular around the feed groove, and a plurality of receiving groove groups respectively extending from the dividing flow channel away from the receiving groove. Each of the accommodating groove groups has a metering groove communicating with the branching channel, a communicating flow path extending from the metering groove toward the feeding groove, and a working groove communicating with the end of the connecting flow path.

In the inspection, the different medicaments are placed in the working tank in advance, and then a film is attached to the top surface of the substrate, and then the inspection target is injected into the feeding tank, and then the microchannel device is made by a machine. The first rotation speed is rotated, and the centrifugal force of the rotation is used to flow the inspection target along the diversion channel into the metering slots of each accommodating groove group, and then the inspection target is distributed to each metering tank according to the size of the chamber of each metering tank, and then The flow channel device rotates at a second rotation speed greater than the first rotation speed to drive the inspection target in each metering tank to flow into the working tank via the communication flow passage to mix the inspection target with different medicaments, and when the inspection target is mixed with different medicaments An optical microscopy device was used for observation after the time.

However, when the liquid separation is performed by the micro-channel device, the tangential force caused by the rotational speed is easily caused to be lost by the splashing of the inspection targets distributed in the respective measuring tanks, and the flow into the working tanks is caused. The dose of the test mark is not accurate, which in turn results in inaccurate test results.

Accordingly, it is an object of the present invention to provide a microchannel device which is capable of avoiding inaccurate doses of inspectors flowing into the respective working cells.

Thus, in some embodiments, the microchannel device of the present invention comprises a substrate, a feed chute, a first liquid separation unit, and a feed flow path. The substrate includes a top surface having a central region at the center and a first annular region surrounding the central region. The feed chute is formed in a central region of the top surface of the substrate. The first liquid separation unit is formed on the top surface of the substrate corresponding to the first annular region, and the first liquid separation unit includes a plurality of receiving groove groups arranged along the circumferential direction of the first annular region, and a connection Each of the accommodating groove groups has a metering groove and a working groove distributed from the branching channel in a radial direction of the first annular region away from the dividing channel. And a communication flow path connecting the metering tank and the working tank. The metering tank has an inflow end portion communicating with the diverting channel and a liquid storage portion between the inflow end portion and the communication flow path, at least the connection between the inflow end portion and the shunt channel is The narrowest area of the metering tank. The inlet flow channel is formed on a top surface of the substrate and communicates between the feed channel and the split channel of the first liquid separation unit, so that the fluid placed in the feed channel enters the first along the feed channel The shunt channel of the liquid separation unit flows into the accommodating groove group via the shunt channel.

In some embodiments, the inflow end of each metering slot is elongated along a radial direction of the first annular region.

In some embodiments, the inflow end of each metering slot has a cross-sectional area that is between one-fifth and one-half of the cross-sectional area of the widest region of the metering slot.

In some implementations, the cross-sectional area of the connecting flow channel of each of the accommodating groove groups is smaller than the cross-sectional area of the inflow end of the accommodating groove group.

In some embodiments, the shunt channel extends along an involute around a center of the central region, the shunt slot having a center connected to the feed channel and adjacent to the central region An inflow end, and an outflow end opposite the center of the inflow end and further away from the central portion.

In some embodiments, the flow channel cross-sectional area of the feed channel is less than the flow channel cross-sectional area of the split channel.

In some embodiments, the top surface further has a second annular region surrounding the first annular region, the microchannel device further comprising a second pair of second annular regions formed on a top surface of the substrate a liquid separation unit, the second liquid separation unit includes a plurality of accommodating groove groups arranged along a circumferential direction of the second annular region, and a shunt channel connecting the accommodating groove groups, and the micro flow channel device further a connecting flow path formed between a shunt channel formed on a top surface of the substrate and communicating with the first liquid separating unit and a shunt channel of the second liquid separating unit to allow a fluid to be placed in the feed chute And entering the diversion channel of the first liquid separation unit along the inflow channel, and flowing into the second diversion channel of the second liquid separation unit via the diversion channel of the first liquid separation unit, and then passing through the The shunt channel of the two liquid separation unit flows into the accommodating groove group of the second liquid separation unit.

In some embodiments, a dredging unit formed on a top surface of the substrate and communicating with an outflow end of the first liquid separation unit, the dredging unit having a draining end from the outflow end away from the center a residual liquid tank extending in the center direction of the region, and an exhaust groove extending from the outflow end portion toward the center of the central portion.

Thus, in some embodiments, the microchannel device of the present invention comprises a substrate, a feed chute, at least one liquid separation unit, and a feed flow path. The substrate includes a top surface having a central region at the center and at least one annular region surrounding the central region. The feed chute is formed in a central region of the top surface of the substrate. The at least one liquid-dividing unit is formed on the top surface of the substrate corresponding to at least one annular region, the liquid-dividing unit includes a plurality of accommodating groove groups arranged along a circumferential direction of the annular region, and a connecting accommodating groove group Diversion channel. Each of the accommodating groove groups has a metering groove and a working groove distributed from the branching channel in a radial direction of the annular region away from the dividing channel, and a connecting flow path connecting the metering groove and the working groove The metering tank has an inflow end portion communicating with the diverting channel and a liquid storage portion interposed between the inflow end portion and the communication flow path, at least a connection point between the inflow end portion and the diverting channel It is the narrowest area of the metering tank. The feed flow path is formed on a top surface of the substrate and communicates with the feed chute and the split flow channel of the liquid separation unit, so that the fluid placed in the feed chute enters the liquid separation unit along the feed flow path The shunt channel flows into the accommodating groove group via the shunt channel.

Therefore, in some embodiments, the microchannel device of the present invention comprises a substrate, a feed chute, a first shunt channel, and a plurality of first receiving trough groups. The feed chute is formed on the substrate. The first shunt channel is connected to the feed chute and is annular around the feed chute; the first accommodating groove group is connected to the first shunt channel in the circumferential direction of the first shunt channel, respectively. a receiving slot group includes a metering slot closer to the first splitting channel, a communicating channel communicating with the metering slot, and a working slot communicating with the connecting channel, the metering slot having a first shunt An inflow end portion of the channel and a liquid storage portion between the inflow end portion and the communication flow path, and a cross-sectional area of the inflow end portion of each of the metering grooves is smaller than a cross-sectional area of the liquid storage portion.

In some embodiments, the flow passage cross-sectional area of the communication flow passage of each of the accommodating groove groups is smaller than the cross-sectional area of the inflow end portion.

The present invention has at least the following effects: by communicating with the inflow channel and being the inflow end of the narrowest region of the metering groove, the tangential force caused by the rotation is prevented from splashing back the fluid distributed in each metering tank The channels are lost to make the dose of fluid flowing into each working tank more accurate.

Before the present invention is described in detail, it should be noted that in the following description, similar elements are denoted by the same reference numerals.

Referring to Figures 1 to 3, a first embodiment of the microchannel device 10 of the present invention can be applied to the inspection of a fluid inspection target (not shown, hereinafter referred to as the inspection target fluid) and different medicaments (Fig. The first embodiment comprises a substrate 1, a feed chute 2, a first liquid separation unit 3, and a feed flow path 4. In the first embodiment, the material of the substrate 1 is plastic, but is not limited thereto.

The substrate 1 includes a top surface 11 having a central region 111 at the center and a first annular region 112 surrounding the central region 111.

The feed chute 2 is formed in the central region 111 of the top surface 11 of the substrate 1. The first liquid separation unit 3 is formed on the top surface 11 of the substrate 1 corresponding to the first annular region 112. The first liquid separation unit 3 includes a plurality of accommodating groove groups 31 arranged along the circumferential direction of the first annular region 112, and A flow dividing channel 32 is connected to the accommodating groove group 31. Each accommodating groove group 31 has a metering groove 311 which is distributed from the branching channel 32 in the radial direction of the first annular region 112 away from the branching channel 32. A working tank 312 and a communicating flow path 313 connecting the metering tank 311 and the working tank 312. The metering tank 311 has an inflow end portion 311a communicating with the diverting channel 32 and a liquid storage portion 311b interposed between the inflow end portion 311a and the communication flow path 313, and at least the connection between the inflow end portion 311a and the diverting channel 32 It is the narrowest area of the metering groove 311. The feed channel 4 is formed on the top surface 11 of the substrate 1 and communicates with the feed channel 2 and the split channel 32 of the first liquid separation unit 3, so that the fluid placed in the feed tank 2 (ie, the test target fluid) is inserted. The flow path 4 enters the flow dividing channel 32 of the first liquid separation unit 3 and flows into the accommodating groove group 31 via the flow dividing channel 32. It should be noted that in a variant embodiment, the microchannel device 10 does not have a feed channel 4, and the feed channel 2 of the microchannel device 10 and the split channel 32 of the first liquid separation unit 3 For direct communication, this is not a limitation.

In more detail, the application mode of the first embodiment is that a plurality of medicines are respectively placed in each working tank 312 in advance, and then a film 8 is attached to the top surface 11 of the substrate 1 to close the feeding trough 2. The first liquid separation unit 3 and the feed flow path 4 are located at the opening of the top surface 11, and a feed hole 81 is formed at the corresponding feed slot 2 of the film 8 to inject the test target fluid, and then a machine is used. The microchannel device 10 is rotated at a first rotation speed, and the flow of the test target placed in the feed tank 2 enters the diversion channel 32 of the first liquid separation unit 3 along the feed flow path 4 by the centrifugal force during rotation. And flowing in the flow channel R1 along the flow channel R1 and sequentially flowing into the metering groove 311 of the accommodating groove group 31 via the branching channel 32, and waiting for the test target fluid to be distributed according to the size of each metering groove 311 After the metering tank 311, the rotation speed of the micro-channel device 10 is increased to rotate at a second rotation speed greater than the first rotation speed, and a larger centrifugal force is used to drive the inspection target fluid in each metering tank 311 through the communication passage. 313 flows into the working tank 312 to inspect the target fluid and various medicaments Together, after the lapse of a period of time to observe the effect of a test target optical microscopic means the case with various agents. Specifically, in the above liquid separation process, the machine rotates the microchannel device 10 in a rotation direction R2 opposite to the flow direction R1.

The connection between the inflow end 311a and the diverting channel 32 is the narrowest region of the metering slot 311, avoiding the tangential force generated by increasing the rotational speed during the process of increasing the first rotational speed to the second rotational speed. The flow of the test target in the metering tank 311 is splashed back to the split channel 32, thereby avoiding inaccurate doses of the test mark flowing into the work tank 312.

In the first embodiment, the inflow end portion 311a of each metering groove 311 has an elongated shape extending along the radial direction of the first annular region 112, and is elongated and narrowest. The inflow end 311a makes it less likely that the inspected fluid will spill back to the diverting channel 32. In the first embodiment, the cross-sectional area of the inflow end 311a of each metering slot 311 is two-fifths of the cross-sectional area of the widest area of the metering slot 311, but is not limited thereto, and other variations are made. In an embodiment, the cross-sectional area of the inflow end portion 311a of each metering groove 311 may also be adjusted within a range of one-fifth to one-half of the cross-sectional area of the widest region of the metering groove 311. In addition, in the first embodiment, the cross-sectional area of the communication channel 313 of each accommodating groove group 31 is smaller than the cross-sectional area of the inflow end portion 311a of the accommodating groove group 31, so that the inspection is performed. The centrifugal force required for the target fluid to pass through the communication passage 313 is greater than the centrifugal force required to pass through the inlet end portion 311a, so that when the microchannel device 10 is rotated at the first rotation speed, the inspection target fluid can pass through the accommodating groove group 31. The flow end portion 311a enters the metering groove 311, but does not enter the working groove 312 through the communication flow path 313 by the metering groove 311.

Further, in the first embodiment, the branching channel 32 of the first liquid separation unit 3 is formed along an involute line around the center of the central region 111, the involute line being along the center of the bypass The angle increases to increase the curvature and gradually away from the center of the central region 111. The flow dividing channel 32 has an inflow end portion 321 connected to the inlet flow channel 4 and closer to the center of the central portion 111, and an outflow end portion 322 opposite to the inflow end portion 321 and farther from the center of the central portion 111. By means of the branching channel 32 of the first liquid separation unit 3 which is substantially involute and gradually away from the center of the central region 111, the test target fluid in the flow dividing channel 32 can be more smoothly rotated by the centrifugal force generated during the rotation. Flows in the splitter channel 32. In addition, in the first embodiment, a dredging unit 7 formed on the top surface 11 of the substrate 1 and communicating with the outflow end portion 322 of the first liquid separation unit 3 is provided. The dredging unit 7 has a self-flowing end. The portion 322 is an exhaust groove 71 extending in the center direction of the central portion 111. In more detail, before the machine is rotated for liquid separation, a vent hole 81 is formed in the corresponding venting groove 71 of the film 8, so that the air pushed by the inflow of the test target can be exhausted. The groove 71 is discharged from the vent hole 81.

In the first embodiment, the flow passage cross-sectional area of the feed flow passage 4 is smaller than the flow passage cross-sectional area of the split flow passage 32 of the first liquid separation unit 3, and the feed flow passage 4 has a meandering shape and has a slight The opening faces the U-shaped turn-around portion 41 away from the central region 111, whereby the test target fluid in the feed tank 2 needs to undergo a certain centrifugal force to flow into the splitter of the first liquid separation unit 3 via the feed flow path 4. The passage 32, and avoiding the flow rate of the inspection target fluid flowing from the feed chute 2 into the splitter passage 32 of the first liquid separation unit 3, is too fast, so that the inspection target fluid cannot fill the metering groove 311 of each of the accommodating groove groups 31.

Referring to FIG. 4 to FIG. 6, a second embodiment of the micro-channel device 10 of the present invention is different from the first embodiment in that the second embodiment further has a top surface 11 A second annular region 113 of an annular region 112, the microchannel device 10 further includes a second liquid separation unit 5 formed on the top surface 11 of the substrate 1 corresponding to the second annular region 113.

The second liquid separation unit 5 includes a plurality of accommodating groove groups 51 arranged along the circumferential direction of the second annular region 113, and a bypass channel 52 connecting the accommodating groove groups 51, and the micro flow channel device 10 further includes a formation a connecting flow path 6 between the splitting channel 32 of the first liquid-dividing unit 3 and the splitting channel 52 of the second liquid-dividing unit 5 on the top surface 11 of the substrate 1 so as to be placed in the feed chute 2 The fluid enters the diversion channel 32 of the first liquid separation unit 3 along the feed channel 4, and can flow into the second diversion channel 52 of the second liquid separation unit 5 via the connection flow path 6, and then through the second liquid separation unit 5 The diverter channel 52 flows into the accommodating groove group 51 of the second liquid separation unit 5. In the second embodiment, the split channel 52 of the second liquid separation unit 5 is formed along another involute line around the center of the central region 111, and the split channel 52 of the second liquid separation unit 5 An inflow end portion 521 connected to the center of the inlet flow path 4 and closer to the central portion 111, and an outflow end portion 522 opposite to the inflow end portion 521 and farther from the center of the central portion 111, and connecting the flow paths 6 is an inflow end portion 322 connected to the first liquid separation unit 3 and an inflow end portion 521 of the second liquid separation unit 5.

In addition, in the second embodiment, each of the accommodating groove groups 51 of the second liquid separation unit 5 has a metering from the branching channel 52 in the radial direction of the second annular region 113 away from the branching channel 52. The groove 511 and a working groove 512, and a communication flow path 513 communicating with the metering groove 511 and the working groove 512, and the flow path cross-sectional area of the communication flow path 513 of the second liquid separation unit 5 is smaller than the communication of the first liquid separation unit 3. The flow path cross-sectional area of the flow path 313. In more detail, when the microchannel device 10 rotates, the test target fluid at the second liquid separation unit 5 is subjected to a centrifugal force that is more distant from the central region 111 than the test target at the first liquid separation unit 3. The centrifugal force of the fluid is large, so the communication passage 513 of the second liquid separation unit 5 having a small cross-sectional area of the flow passage can prevent the inspection target fluid from passing through the second before the micro-flow passage device 10 increases the rotation speed to the second rotation speed. The communication passage 513 of the liquid separation unit 5 passes, and in the second embodiment, the flow path cross-sectional area of the communication flow path 313 of the first liquid separation unit 3 and the flow of the communication flow path 513 of the second liquid separation unit 5 The area ratio of the cross-sectional area is designed according to the proportion of the centrifugal force that the test target fluid at two places is subjected to at the second rotational speed, whereby the micro-fluidic device 10 is rotated at the second rotational speed, the first liquid-dividing unit 3 The test target fluid in the metering tank 311 and the test target fluid in the metering tank 511 of the second liquid separation unit 5 can simultaneously flow into the working tank 312 of the first liquid separation unit 3 and the working tank 512 of the second liquid separation unit 5, respectively. So that the test target fluid can be simultaneously It is mixed with the respective working tanks 312 of the first liquid separation unit 3 and the medicines in the respective working tanks 512 of the second liquid separation unit 5. Further, in the second embodiment, the width of the communication flow path 513 of the second liquid separation unit 5 is the same as the width of the communication flow path 313 of the first liquid separation unit 3, but the communication flow path of the second liquid separation unit 5 The depth of 513 is smaller than the depth of the communication flow path 313 of the first liquid separation unit 3, in other words, the ratio of the flow path cross-sectional area of the communication flow paths 313, 513 of the two is the depth ratio of the communication flow paths 313, 513. Decide. Since the width of the communication flow path 513 of the second liquid separation unit 5 is the same as the width of the communication flow path 313 of the first liquid separation unit 3, the micro flow path device 10 is disposed at the periphery of the communication flow path 513 of the second liquid separation unit 5 And the supporting force of the film 8 covering the top surface 11 at the periphery of the communication flow path 313 of the first liquid separation unit 3 is the same, and the width of the communication flow paths 313, 513 is prevented from increasing, thereby causing the micro flow channel device 10 to overlap the top. The supporting force of the film 8 of the face 11 is insufficient to cause the film 8 to be easily deformed or recessed downward at the corresponding communication passages 313, 513.

In addition, in the second embodiment, the metering groove 511 of the second liquid separation unit 5 also has an inflow end portion 511a that communicates with the diverting channel 52 and a gap between the inflow end portion 511a and the communication flow path 513. Since the liquid storage portion 511b has been described with respect to the inflow end portion 311a and the liquid storage portion 311b of the metering groove 311 of the first liquid separation unit 3, it will not be described again.

In addition, unlike the first embodiment, in the second embodiment, the unblocking unit 7 is connected to the outflow end 522 of the second liquid dividing unit 5, and the unblocking unit 7 has a self-flowing end portion 522 The central portion 111 extends in the center direction and is provided to evacuate the air outside the exhaust groove 71, and has a residual liquid groove 72 extending from the outlet end portion 522 toward the center of the central portion 111. When the microchannel device 10 is rotated at the first rotation speed, the inspection target fluid is distributed to the respective metering tanks 311, 511, and the excess portion flows along the branch channels 32, 52 to the remaining liquid tank 72 to avoid the micro flow passage. When the device 10 is rotated at the second rotational speed, the remaining portion of the test target fluid remaining in the split channels 32, 52 flows into the accommodating groove groups 31, 51, resulting in an inaccurate dose of the test target fluid flowing into the working grooves 312, 512. .

It should be noted that the first embodiment and the second embodiment respectively illustrate the condition that the micro-channel device 10 has one liquid separation unit 3 and two liquid separation units 3, 5, but in other variations, The number of liquid units may also be three or more, and should not be limited by the above embodiments.

It is worth mentioning that the micro-channel device 10 of the present invention can be made by mechanical processing or injection molding, and can also be fabricated through a yellow light process when the required size is miniaturized.

In summary, the micro-channel device 10 of the present invention avoids the tangential direction caused by the rotation by the inflow end portions 311a, 511a which are connected to the diverting channels 32, 52 and which are the narrowest regions of the metering grooves 311, 511. The force is caused to be lost by the splash-back shunt channels 32, 52 distributed in the metering tanks 311, 511, so that the dose of the test mark flowing into each of the working grooves 312, 512 is more accurate.

However, the above is only the embodiment of the present invention, and the scope of the invention is not limited thereto, and all the equivalent equivalent changes and modifications according to the scope of the patent application and the patent specification of the present invention are still The scope of the invention is covered.

10‧‧‧Microchannel device
1‧‧‧Substrate
11‧‧‧ top surface
111‧‧‧Central area
112‧‧‧First ring area
113‧‧‧second ring zone
2‧‧‧feed trough
3‧‧‧First Dispensing Unit
31‧‧‧ accommodating slot group
311‧‧‧ metering tank
311a‧‧‧ Inflow end
311b‧‧‧Liquid Storage Department
312‧‧‧Working trough
313‧‧‧Connected runners
32‧‧‧Diversion channel
321‧‧‧ Inflow end
322‧‧‧ outflow end
4‧‧‧Infeed runner
41‧‧‧迂回部
5‧‧‧Second liquid separation unit
51‧‧‧ accommodating slot group
511‧‧‧ metering tank
511a‧‧‧ Inflow end
511b‧‧‧ liquid storage department
512‧‧‧Working trough
513‧‧‧Connected runners
52‧‧‧Diversion channel
521‧‧‧ Inflow end
522‧‧‧ outflow end
6‧‧‧Connecting the runner
7‧‧‧Draining unit
71‧‧‧Exhaust trough
72‧‧‧ residual tank
8‧‧‧film
81‧‧‧Inlet hole
82‧‧‧Ventinel
R1‧‧‧ flow direction
R2‧‧‧Rotation direction

Other features and advantages of the present invention will be apparent from the embodiments of the present invention, wherein: Figure 1 is a perspective view of a first embodiment of the microchannel device of the present invention; Figure 3 is an incomplete cross-sectional view taken along line III-III of Figure 2; Figure 4 is a perspective view of a second embodiment of the micro-channel device of the present invention; A top view of the second embodiment; and Fig. 6 is an incomplete cross-sectional view taken along line VI-VI of Fig. 5.

Claims (11)

A microchannel device comprising: a substrate comprising a top surface, the top mask having a central portion at a center, and a first annular region surrounding the central region; a feed slot formed on the substrate a central portion of the top surface; a first liquid separation unit corresponding to the first annular region formed on the top surface of the substrate, the first liquid separation unit including a plurality of circumferential directions arranged along the first annular region a accommodating slot group, and a shunting channel connecting the accommodating slot groups, each accommodating slot group having a distribution from the shunting channel in a radial direction of the first annular region away from the shunting channel a metering tank and a working tank, and a communicating flow path connecting the metering tank and the working tank, the metering tank having an inflow end portion communicating with the diverting channel and an inflow end portion and the connecting flow portion a liquid storage portion between the channels, at least the connection between the inflow end portion and the shunt channel is a narrowest region of the metering groove; and a feed flow path formed on a top surface of the substrate and communicating the material a groove and a split channel of the first liquid separation unit to enable the placement of the The fluid entering the feed tank enters the diversion channel of the first liquid separation unit along the feed flow path, and flows into the accommodating groove group through the distribution channel. The microchannel device according to claim 1, wherein the inflow end of each of the metering grooves has an elongated shape extending in a radial direction of the first annular region. The microchannel device according to claim 2, wherein the cross-sectional area of the inflow end of each of the metering slots is one-fifth to one-half of the cross-sectional area of the widest region of the metering tank. The microchannel device according to claim 1, wherein a cross-sectional area of the communication channel of each of the accommodating groove groups is smaller than a cross-sectional area of the inflow end of the accommodating groove group. The micro-channel device of claim 1, wherein the shunt channel extends along an involute surrounding a center of the central region, and the shunt slot has a connection to the feed channel and An inflow end adjacent the center of the central region, and an outflow end opposite the center of the inflow end and further away from the central portion. The microchannel device according to claim 1, wherein the flow channel cross-sectional area of the inflow channel is smaller than the channel cross-sectional area of the branch channel. The microchannel device of any one of claims 1 to 6, wherein the top surface further has a second annular region surrounding the first annular region, the microchannel device further comprising a pair of a second liquid-dividing unit formed on the top surface of the substrate, the second liquid-dividing unit includes a plurality of accommodating groove groups arranged along the circumferential direction of the second annular region, and a connecting accommodating groove a group of diverting channels, and the microchannel device further comprises a connection between a shunt channel formed on a top surface of the substrate and communicating with the first liquid separation unit and a shunt channel of the second liquid separation unit a flow path, so that the fluid placed in the feed tank enters the split channel of the first liquid separation unit along the feed flow path, and can flow into the second liquid separation through the split flow channel of the first liquid separation unit The second diversion channel of the unit flows into the accommodating groove group of the second liquid separation unit via the diversion channel of the second liquid separation unit. The micro-channel device according to claim 5, further comprising a dredging unit formed on a top surface of the substrate and communicating with an outflow end of the first liquid-dividing unit, the dredging unit having a self-extracting unit The flow end portion has a residual liquid groove extending away from the center direction of the central portion, and an exhaust groove extending from the outflow end portion toward the center direction of the central portion. A microchannel device comprising: a substrate comprising a top surface, the top mask having a central region at the center, and at least one annular region surrounding the central region; a feed slot formed at the top of the substrate a central portion of the surface; at least one liquid separation unit, at least one annular region is formed on a top surface of the substrate, the liquid separation unit includes a plurality of accommodating groove groups arranged along a circumferential direction of the annular region, and a connection Each of the accommodating tanks has a metering slot and a working slot distributed from the shunting channel in a radial direction of the annular region away from the shunting channel, and a communication slot a flow passage connecting the metering tank and the working tank, the metering tank having an inflow end portion communicating with the diverting channel and a liquid storage portion between the inflow end portion and the communication flow path, at least the inflow a junction of the end portion and the flow dividing channel is a narrowest region of the metering groove; and a feed flow path formed on a top surface of the substrate and communicating the flow channel and the branching channel of the liquid separation unit to The fluid along the feed chute The inflow channel enters the diversion channel of the liquid separation unit, and flows into the receiving groove group through the diversion channel. A microchannel device comprising: a substrate; a feed chute formed on the substrate; a first shunt channel communicating with the feed chute and surrounding the feed chute; and a plurality of first receiving The slot group is connected to the first split channel along the circumferential direction of the first split channel. Each of the first receiving slot groups includes a metering slot closer to the first split channel and a communication connecting the metering slot. a flow channel, and a working groove communicating with the connecting flow channel, the metering groove having an inflow end portion communicating with the first diverting channel and a liquid storage portion interposed between the inflow end portion and the communicating flow path And the cross-sectional area of the inflow end of each of the metering tanks is smaller than the cross-sectional area of the liquid storage portion. The micro-channel device according to claim 10, wherein a cross-sectional area of the communication channel of each of the accommodating groove groups is smaller than a cross-sectional area of the inflow end.