TWI612939B - Method and device for detecting blood flow rate - Google Patents

Description

Method and device for detecting blood flow rate

The invention relates to a method for detecting blood flow rate and a device thereof, in particular to a method and a device for detecting blood flow rate by photoplethysmographic (PPG).

According to the blood flow rate is an important physiological feature of the human body, many scholars have proposed a variety of different detection schemes to specifically detect the blood flow rate. With the advancement of medicine, the invasive measurement scheme has gradually been replaced by a non-invasive measurement scheme, which is most commonly used by Vascular visualizer or Doppler ultrasonography. However, the above two measurement methods require the construction of a large number of testing equipment, and a large amount of consumables are required for the detection, which imposes application limitations.

Furthermore, with the rise of wearable devices, many consumers have worn wearable devices to detect their physiological characteristics at any time through the detection function on the wearable device. However, the above-mentioned blood flow rate measurement scheme, whether it is a blood vessel, can be known from the above. Both the development technology and the Doppler ultrasound technology require a large inspection setup that cannot be applied to the wearable device.

However, the manufacturer has proposed a patent of the Chinese Patent No. I517838, which discloses a blood flow sensing device that defines a different position on the user's testicle or scrotum. Compare the measurement area with a reference measurement area. The blood flow sensing device includes a sensor, a comparison unit, and a display unit. The sensor transmits the contrast measurement area and the reference measurement area by a specific wavelength light source, and receives the comparison quantity. The reflected light of the measurement area and the reference measurement area is used to obtain a comparison pulse information, a reference pulse information, a contrast blood oxygen concentration information and a reference blood oxygen concentration information. The comparing unit compares the contrast pulse information and the contrast blood oxygen concentration information according to the reference pulse information and the reference blood oxygen concentration information, respectively, according to the comparison result to generate the inside of the blood vessel of the contrast measuring area and the reference measuring area a relative blood flow state between the blood vessels, and according to the relative blood flow state, determining a blocked state or a disconnected state between the blood vessels of the contrast measuring zone and the blood vessels of the reference measuring zone. Finally, the relative blood flow state is displayed by the display unit. However, the above-mentioned patents need to pass through a plurality of sets of sensors to measure the comparison measurement area and the reference measurement area at the same time, and the comparison measurement area and the reference measurement area must have a certain amount. The distance is not conducive to the application of the wearable device. In addition, during the implementation of the above patent case, only the state of blood flow can be judged, and the blood flow rate cannot be specifically obtained.

SUMMARY OF THE INVENTION A primary object of the present invention is to provide a method and apparatus for detecting a blood flow rate that is suitable for use in a wearable device and that has a simple detection mode.

In order to achieve the above object, the present invention provides a method for detecting a blood flow rate, comprising the steps of: providing a detection light source, causing the detection light source to project toward a biological skin within a detection time and penetrating the biological skin to a blood vessel; Step 2: receiving, by an optical sensing component, the polarized light reflected by the detecting light source when the blood vessel is dilated or contracted, and the detecting light source is reflected to the optical sensing component at a first polarizing angle when the blood vessel is relaxed, so that the optical sensing The device generates a first optical volume signal, and the detecting light source reflects to the optical at a second polarizing angle different from the first polarizing angle when the blood vessel contracts Sensing the optical sensing component to generate a second optical volume signal; Step 3: obtaining at least one first optical volume signal and at least one second optical volume signal during the detection time by using a micro processing unit, and sequentially, the first light based on the processing time of the micro processing unit The volume signal and the second light volume signal calculate a light-receiving offset and a time-varying amount, and convert the blood flow rate by the light-receiving offset and the time change.

In an embodiment, the step 1 further comprises a sub-step of continuously projecting the biological skin at a light-emitting frequency during the detecting time.

In an embodiment, the step 1 further includes a sub-step of providing a compensation light source for continuously projecting toward the biological skin within a detection time.

In an embodiment, the optical sensing component is composed of a plurality of optical sensing units, and the polarized light reflected by the detecting light source when the blood vessel is dilated or contracted is sent to one of the different optical sensing units, and the polarized light is received. The optical sensing unit generates the first optical volume signal or the second optical volume signal.

In an embodiment, the second step further comprises a sub-step of filtering the first optical volume signal and the second optical volume signal.

In an embodiment, the step 2 further includes a sub-step of determining, by the micro-processing unit, a portion that enables the optical sensing units to receive the polarized light reflected by the detecting light source due to relaxation or contraction of the blood vessel, and the rest The other part of the optical sensing unit is set to disable.

In addition, the present invention also provides a device for detecting blood flow rate, the device comprising a device body, a light source generating member, and a microprocessor. The device body defines a detecting portion, and the detecting portion corresponds to a biological skin device. The light source generating member is disposed in the device body and is exposed to the detecting portion. After the light source generating device is enabled, a detecting light source is generated and the detecting is performed. Light The source projects toward the biological skin and penetrates the biological skin to a blood vessel. The optical sensing member is disposed in the device body and is exposed to the detecting portion. After the optical sensing device is enabled, the detecting light source is subjected to the blood vessel to relax or contract. The polarized light reflected by the optical sensing member receives the polarized light reflected by the first polarizing angle to generate a first optical volume signal when the blood vessel is dilated, and the optical sensing member receives a second polarized light when the blood vessel contracts Another polarized light of the angle reflection generates a second optical volume signal, the micro processing component is disposed in the device body and is connected to the light source generating component and the optical sensing component, and the micro processing component receives at least one from the optical sensing component The first optical volume signal and the at least one second optical volume signal, and calculating a light-receiving offset and a time variation based on the sequentially-ordered first optical volume signal and the second optical volume signal, The light-receiving offset and the amount of time change convert a blood flow rate.

In an embodiment, the device further includes a filter connected to the optical sensing component to filter the first optical volume signal and the second optical volume signal, and a bridge between the filtering component and the micro processing component. Analogical digital conversion between.

In one embodiment, the device further includes a compensation light source generating member disposed in the body of the device and exposed to the detecting portion, the compensating light source generating member working in synchronization with the light source generating member and projecting a compensation light source to the biological skin . Further, the compensation light source is a white light.

In one embodiment, the optical sensing component is comprised of a plurality of optical sensing units. Further, the optical sensing units are arranged in a matrix arrangement.

In one embodiment, the device further includes a switching device that connects the micro-processing member and the optical sensing units and is controlled by the micro-processing device to enable or disable portions of the optical sensing units.

Through the above technical solutions, it has the following characteristics compared to the conventional ones: The light source generating member projects the detecting light to the same position of the biological skin, and then receives the polarized light reflected by the detecting light source due to the relaxation or contraction of the blood vessel, and obtains the first light volume signal and the first The second light volume signal is finally calculated by the micro processing unit based on the first light volume signal and the second light volume signal in the detection time, and the light receiving offset and the time change amount are used to receive the light. The offset and the amount of time change translate a blood flow rate. Thereby, the structure of the present invention is simpler and can be specifically applied to a wearable device. In addition to this, the method of the present invention achieves the blood flow rate in a simpler calculation method than in the prior art.

10‧‧‧ device body

11‧‧‧Light source generating parts

111‧‧‧Detection light source

112‧‧‧First polarizing angle

113‧‧‧second polarizing angle

12‧‧‧Light source sensing

121‧‧‧Optical sensing unit

122‧‧‧First light volume signal

123‧‧‧Second light volume signal

13‧‧‧Microprocessors

14‧‧‧Detection Department

141‧‧‧through hole

15‧‧‧Compensated light source generating parts

151‧‧‧Compensated light source

16‧‧‧Filter

17‧‧‧ analog digital converter

18‧‧‧Switches

2‧‧‧ Biological skin

21‧‧‧ blood vessels

31, 311, 312, 32, 321, 322, 33 ‧ ‧ steps

FIG. 1 is a schematic diagram of the appearance of a device according to an embodiment of the invention.

2 is a schematic diagram showing the composition of a device unit according to an embodiment of the present invention.

FIG. 3 is a schematic flow chart of a method according to an embodiment of the present invention.

4 is a schematic structural view of a light sensing device according to an embodiment of the present invention.

FIG. 5 is a schematic diagram (1) of a detection implementation according to an embodiment of the invention.

FIG. 6 is a schematic diagram (2) of a detection implementation according to an embodiment of the invention.

FIG. 7 is a partial schematic view of light reflection according to an embodiment of the present invention.

FIG. 8 is a schematic flow chart of a method according to another embodiment of the present invention.

The detailed description and technical contents of the present invention will now be described as follows:

Referring to FIG. 1 to FIG. 2, the present invention provides a method for detecting blood flow rate and a device thereof, the device comprising a device body 10, a light source generating member 11, an optical sensing member 12, and A micro-processing member 13.

The device of the present invention can be a wearable device, such as a smart wristband, a smart watch, etc., and the device body 10 has a corresponding structural design according to an implementation requirement. The device body 10 provides the light source generating member 11 and the optical device. The sensing device 12 and the micro-processing member 13 are disposed therein. The device body 10 defines a plane of the outer edge thereof as the detecting portion 14 , and at least two through holes 141 are defined in the corresponding detecting portion 14 to enable the light source. The generating member 11 and the optical sensing member 12 are respectively disposed in one of the through holes 141. Thus, the light source generating member 11 and the optical sensing member 12 can be exposed to the detecting portion 14. In addition, the detecting portion 14 of the present invention can further be disposed corresponding to a biological skin 2, that is, the device of the present invention can be applied to the biological skin 2 for measurement during implementation. On the other hand, the light source generating member 11 is activated to generate a detecting light source 111. The detecting light source 111 can be an invisible infrared light whose wavelength can be adjusted according to the detection requirement, such as 660 nm or 940 nm.

Moreover, the optical sensing device 12 is enabled to receive the polarized light generated by the detecting light source 111 reflected by other objects, and photoelectrically react to generate an electrical signal. Furthermore, referring to FIG. 3, the optical sensing component 12 can be further composed of a plurality of optical sensing units 121, each of which can receive the polarized light generated by the detecting light source 111 by other objects and convert it into a telecommunication. The optical sensing units 121 may be arranged in a matrix, and any two of the optical sensing units 121 have a pitch.

Moreover, the micro-processing member 13 is connected to the light source generating member 11 and the optical sensing member 12, and the micro-processing member 13 is configured to have at least one working mode to determine the light source generating member 11 and the optical sensing member 12. In addition, the microprocessor 13 further receives the electrical signal generated by the optical sensing component 12, and analyzes the electrical signal to obtain a blood flow rate.

With reference to FIG. 4, the method for detecting blood flow rate according to the present invention includes the following steps: Step one 31: providing the detection light source, causing the detection light source 111 to project toward the biological skin 2 within a detection time to penetrate the The biological skin 2 is directed to a blood vessel 21; Step 2: 32: receiving, by the optical sensing member 12, the polarized light reflected by the detecting light source 111 when the blood vessel 21 is relaxed or contracted, and the detecting light source 111 is first when the blood vessel 21 is relaxed. The polarization angle 112 is reflected on the optical sensing component 12, and the optical sensing component 12 generates a first optical volume signal 122. When the blood vessel 21 is contracted, the detection light source 111 is different from the first polarization angle 112. The second polarizing angle 113 is reflected on the optical sensing component 12 to cause the optical sensing component 12 to generate a second optical volume signal 123; and in step 333: at least one of the first detecting time is obtained through the microprocessing component 13 The light volume signal 122 and the at least one second light volume signal 123 are calculated by the micro processing unit 13 based on the first light volume signal 122 and the second light volume signal 123 sequentially in the detection time. Offset And a time change amount, wherein the blood flow rate is converted by the light collection offset and the time change amount.

The method of the present invention is specifically described, and please refer to FIG. 5 and FIG. 6 at the same time. At the beginning of the implementation, the detecting portion 14 of the device body 10 is first placed on the biological skin 2 to be detected, for example, placed on the wrist of the human body, or The human chest position is set, and the light source generating member 11 and the light source sensing member 12 are disposed facing the biological skin 2. Then, the micro-processing member 13 is caused to count the detection time, for example, five seconds, to enable the light source generating member 11 and the light source sensing member 12 to cause the light source generating member 11 to project the detecting light source 111 toward the biological skin 2. The light source 111 penetrates the biological skin 2 and is directed to the blood vessel 21, and proceeds to step two 32. Furthermore, in the detection process of the present invention, the detection light source 111 is cast To the same position of the biological skin 2.

During the implementation of the second step 32, the micro-processing member 13 has not exceeded the detection time, and continues to cause the light source generating member 11 to project the detecting light source 111 on the biological skin 2, and receive the detecting light source by using the optical sensing member 12. 111 Polarized light reflected by the blood vessel 21 when it is relaxed or contracted. It is assumed that, when the blood vessel 21 is in diastole at the beginning of the detection, the detecting light source 111 will be subjected to the wall of the tube when the blood vessel 21 is relaxed, and reflected by the first polarizing angle 112 to the optical sensing member 12, the optical sensing member The first optical volume signal 122 is then generated. Then, when the blood vessel 21 enters the contraction by dilation, the detecting light source 111 is changed by the tube wall of the blood vessel 21, and is reflected to the optical sensing member 12 at the second polarizing angle 113 different from the first polarizing angle 112. The optical sensing component 12 is caused to generate the second optical volume signal 123. For further exemplification, the optical sensing component 12 of the present invention is composed of a plurality of optical sensing units 121. When the blood vessel 21 is relaxed, the detecting light source 111 is reflected by the first polarizing angle 112 to one of the optical sensing units 121. When the blood vessel 21 is contracted, the detecting light source 111 will be reflected to another optical sensing unit 121 due to the angle of the second polarizing angle 113 and the first polarizing angle 112, as shown in FIG. 7 and At this time, one of the optical sensing units 121 that has received the detection light source 111 generates the second optical volume signal 122, and proceeds to step 3-23.

The micro-processing unit 13 obtains at least one of the first optical volume signal 122 and the at least one second optical volume signal 123 during the detection time, and continuously one of the first optical volume signals 122 and one of the first optical volume signals 122. The second optical volume signal 123 is used as a detection group to analyze the first optical volume signal 122 and the second optical volume signal 123 in the detection group to obtain a light-receiving offset and a time variation. Furthermore, in order to increase the feasibility of the detection result, the present invention analyzes and counts the plurality of detection groups to produce a result. Moreover, as can be seen from the foregoing description, the first optical volume signal The first optical volume signal 122 and the second optical volume signal 12 are generated by the optical sensing unit 121, and the second optical volume signal 12 is generated by the optical sensing unit 121. Two of the optical sensing units 121 of the signal 123 calculate the distance difference and obtain the light-receiving offset. On the other hand, the microprocessor 13 calculates the time difference based on the generation time of the first optical volume signal 122 and the generation time of the second optical volume signal 123 to obtain the time variation. Thereafter, the micro-processing member 13 calculates the light-receiving offset amount and the time change amount, and divides the light-receiving offset amount by the time change amount to obtain the blood flow rate.

Referring to FIG. 8 , in an embodiment, the step 31 further includes a sub-step 311 of continuously projecting the biological skin 2 at a light-emitting frequency during the detection time. In detail, during the implementation of the sub-step 311, the micro-processing unit 13 controls the light source generating member 11 to continuously project the biological skin 2 at the light-emitting frequency, and the light-emitting frequency is adjusted according to the detection requirement. .

On the other hand, in the present invention, the light source sensing member 12 can more reliably sense the reflection of the detecting light source 111. The device of the present invention can further have a compensation provided on the device body 10 and exposed to the detecting portion 14. The light source generating member 15 is electrically connected to the micro-processing member 13 and controlled by the micro-processing member 13. The compensation light source generating member 15 is set to operate in synchronization with the light source generating member 11, and a compensation light source 151 is projected toward the biological skin 2. The compensation light source 151 can be a trace of white light. The compensation light source 151 is intended to enable the photoelectric structure on the light source sensing member 12 to enter the working area when the detection light source 111 is not received, and the detection light source 111 can be effectively sensed. Specifically, the effect of ambient light on detection is reduced. Accordingly, the method of the present invention includes a sub-step 312 in step 31: providing the compensation light source 151 to cause the compensation light source 151 to continue projecting toward the biological skin 2 during the detection time.

Referring to FIG. 8, the second step 32 of the method of the present invention further includes a sub-step 321 of filtering the first optical volume signal 122 and the second optical volume signal 123. More specifically, in this embodiment, the device has a filter member 16 disposed in the device body 10 and connected to the optical sensing member 12. The filter member 16 receives each of the first ones generated by the optical sensing device 12. The optical volume signal 122 and each of the second optical volume signals 123 are filtered for each of the first optical volume signals 122 and each of the second optical volume signals 123 to ensure quality of subsequent information processing. Furthermore, the filter 于此 disclosed herein can be designed as band pass filtering, low pass filtering, etc. according to implementation requirements, and is not limited thereto. In addition, the device of the present invention further has an analog digital converter 17 bridged between the filter member 16 and the micro-processing member 13. Thereby, the micro-lightpiece 13 is operated by converting the first optical volume signal 122 and the second optical volume signal 123 into analog numbers by analogy.

As described above, the present invention further includes a sub-step 322 in the step 2: using the micro-processing unit 13 to determine the portion of the optical sensing unit 121 that is enabled to receive the detection light source 111 due to the relaxation of the blood vessel 21 or The polarized light reflected during contraction, and the other portions of the other optical sensing units 121 are set to be disabled. More specifically, in an embodiment, the light source sensing component 12 is composed of a plurality of optical sensing units 121. To specifically control the operation of each of the optical sensing units 121, the device further includes a connecting the micro processing component. 13 and the switch member 18 of the optical sensing unit 121, the switch member 18 is controlled by the micro control unit 13 to enable or disable portions of the optical sensing unit 121. For example, the micro-controller 13 controls each of the optical sensing units 121 belonging to the same row in the optical sensing units 121 to be activated, and the rest is disabled. Thereby, the conversion of the light-receiving offset is simplified.

The present invention has been described in detail above, but the foregoing is only a preferred embodiment of the present invention, and is not intended to limit the scope of the present invention. Equivalent changes and modifications made to the scope of the patent application are still within the scope of the patents of the present invention.

31, 32, 33‧ ‧ steps

Claims (11)

A method for detecting blood flow rate, comprising the steps of: step 1: providing a detection light source, causing the detection light source to project toward a biological skin within a detection time and penetrating the biological skin to a blood vessel located on the surface layer of the biological skin; : receiving, by an optical sensing component, the polarized light reflected by the detecting light source due to relaxation or contraction of the blood vessel, wherein the optical sensing component is composed of a plurality of optical sensing units, and the detecting light source is converted by the polarized light reflected by the blood vessel during relaxation or contraction And the optical sensing unit is configured to reflect the light source to the optical sensing unit at a first polarization angle, and the optical sensing unit generates a first optical volume signal for the blood vessel When the light is contracted, the detecting light source is reflected to the other optical sensing unit by a second polarizing angle different from the first polarizing angle, so that the optical sensing unit generates a second optical volume signal; and step 3: transmitting a micro Processing the device to obtain at least one of the first optical volume signal and the at least one second optical volume signal during the detecting time, and The micro-processing device calculates a light-receiving offset and a time-varying amount based on the first light volume signal and the second light volume signal in sequence during the detecting time, and the light-receiving offset and the time change The amount is converted into a blood flow rate, wherein the light-receiving offset is obtained by calculating a distance difference between the detection unit that generates the first polarization angle and the second polarization angle. The method for detecting blood flow rate according to claim 1, wherein the step 1 further comprises a sub-step of continuously projecting the biological skin at a light-emitting frequency during the detecting time. The method for detecting a blood flow rate according to claim 1, wherein the step 1 further comprises a substep of: providing a compensation light source for continuously projecting toward the biological skin within a detection time. The method for detecting blood flow rate according to claim 1, wherein the step 2 further comprises a sub-step of filtering the first optical volume signal and the second optical volume signal. The method for detecting blood flow rate according to claim 1, wherein the step 2 further comprises a sub-step of: determining, by the micro-processing member, a portion enabling the optical sensing units to receive the detection light source due to the vasodilation or The polarized light reflected during contraction, and the rest of the other optical sensing units are set to disable. A device for detecting a blood flow rate, comprising: a device body defining a detecting portion, the detecting portion corresponding to a biological skin setting; a light source generating member disposed in the device body and exposed in the detecting portion, the light source is generated After the device is enabled, a detection light source is generated and the detection light source is projected toward the biological skin and penetrates the biological skin to a blood vessel located on the surface layer of the biological skin; an optical sensing component is disposed in the body of the device and is exposed to the detection The optical sensing unit is composed of a plurality of optical sensing units, and the optical sensing unit is configured to receive the polarized light reflected by the detecting light source when the blood vessel is dilated or contracted, and one optical sensing unit accepts one when the blood vessel is dilated The polarized light reflected by the first polarizing angle generates a first optical volume signal, and the other optical sensing unit receives another polarized light reflected by a second polarizing angle to generate a second optical volume signal when the blood vessel contracts; And a micro-processing member disposed in the body of the device and connecting the light source generating member and the optical sensing member, the micro-processing member being optically sensible Receiving at least one of the first optical volume signal and the at least one second optical volume signal, and calculating a time variation based on the sequentially first optical volume signal and the second optical volume signal, based on generating the first polarized light Angle and distance between the second polarizing angle and the detecting unit The difference is obtained as a light-receiving offset, and a blood flow rate is converted by the light-receiving offset and the time-varying amount. The device for detecting blood flow rate according to claim 6, further comprising: a filter connected to the optical sensing device to filter the first optical volume signal and the second optical volume signal, and a bridge between the filter and the filter Analog to digital converter between microprocessors. The device for detecting a blood flow rate according to claim 6 or 7, further comprising a compensation light source generating member disposed in the body of the device and exposed to the detecting portion, the compensating light source generating member working in synchronization with the light source generating member and The biological skin projects a compensating light source. The apparatus for detecting a blood flow rate according to claim 8, wherein the compensation light source is a white light. The apparatus for detecting a blood flow rate according to claim 6, wherein the optical sensing units are arranged in a matrix arrangement. The device for detecting blood flow rate according to claim 6, further comprising a switch member connecting the micro-processing member and the optical sensing units and being controlled by the micro-processing member to enable or disable the optical sensing unit.