TWI610695B - Sterilizing glue - Google Patents

Description

Sterilizing glue

The case relates to a cleaning and disinfecting product, in particular to a sterilization glue.

Taiwan Patent Publication No. 201404712 discloses a chlorine dioxide gel and a preparation method thereof. In the patent, a polymer gel is prepared, and an aqueous solution of chlorine dioxide is added to the polymer gel to prepare a chlorine dioxide gel. The polymer gel is obtained by heating polyethylene glycol and bis-decyltetradecyl alcohol by adding water. Chlorine dioxide is a gas at room temperature and is easily lost and not easy to store. In this patent, although a gel is used to preserve chlorine dioxide, the effect is not good. After testing, the concentration of chlorine dioxide contained in the finished product obtained by the method of the patent method is reduced to the original 20% after seven days. Chlorine dioxide gels with a short effective period, even if they are sold as products, will not be popular with consumers due to poor sterilization and impracticality, and need to be improved.

The purpose of the present invention is to provide a sterilizing rubber material having a long sterilization storage period.

The sterilizing rubber material comprises a colloidal solution and an aqueous chlorine dioxide solution. The total weight of the sterilizing rubber is 100% by weight, and the colloid includes 0.5% by weight to 5% by weight of polyvinyl alcohol, 0.5% by weight to 5% by weight of polyethylene glycol, and 0.5% by weight to 5% by weight of Sanxianjiao. And 0.01% to 2% by weight of calcium chloride. The aqueous chlorine dioxide solution is dispersed in the colloid. The total weight of the sterilizing gel is 100% by weight, and the aqueous chlorine dioxide solution comprises 0.1% by weight to 5% by weight of chlorine dioxide, and a total of 100% by weight of water combined with other components.

The polyvinyl alcohol (PVA) has a hydroxyl group capable of generating hydrogen bonds in its main chain. The polyethylene glycol (PEG) is a linear micropolar polymer having a plurality of oxygen atoms in its main chain and capable of forming hydrogen bonds. The calcium chloride (CaCl ₂ ) can dissociate calcium ions, and the polyvinyl alcohol and the polyethylene glycol are centered on the calcium ions to form a special three-dimensional structure, and can be retained and sealed. Aqueous chlorine dioxide solution. The three-dimensional structure has a plurality of meshes each having a size of between 60 nm and 90 nm.

When the ratio of the polyvinyl alcohol, the polyethylene glycol and the calcium chloride is less than 0.5 wt%, 0.5 wt% and 0.01 wt%, respectively, the finished product cannot be effectively formed. The three-dimensional structure cannot effectively retain the chlorine dioxide. When the proportion of calcium chloride is more than 2% by weight, the finished product will be solidified It is too hard for the user to apply.

There are quite a few factors to be considered in the finished product produced in this case. In addition to considering whether it is possible to effectively retain the aqueous solution of chlorine dioxide, it is also necessary to consider whether the components are compatible and the stability of the finished product. The compatibility between the components of the case and the stability of the finished product depend on the synergistic ratio of polyvinyl alcohol, polyethylene glycol, and Sanxianjiao, and cannot be determined only by controlling the proportion of one of them. It has been confirmed by experiments that the amount of polyvinyl alcohol and polyethylene glycol should be less than 5%, and the amount of Sanxian gum should be between 0.5% and 5%, otherwise the finished product is easy to produce water. That is to say, if the components are not within the scope of the present case, they cannot be well combined with each other, so that the chlorine dioxide aqueous solution is lost outside the finished product, and the finished product is unusable.

The chlorine dioxide is a gas at a normal temperature, and has a solubility of about 7.8 g/L at 25 ° C and a gas phase partial pressure of chlorine dioxide of 100 mmHg. In order to achieve a certain bactericidal effect and not excessive stimulation in the present case, the finished product of the present invention preferably contains 0.1% by weight to 5% by weight of chlorine dioxide.

In the present case, water is used as a solvent, and the cost is low, because the water is easy to obtain, and the use of the organic solvent does not require disposal of the waste liquid in the process, and is safe for use in the human body. More importantly, since chlorine dioxide is dissolved in water, when water is hydrogen-bonded to the aforementioned polyvinyl alcohol and is retained in the colloid, the chlorine dioxide is also retained in the water, and is effectively Save it.

The efficacy of the sterilizing glue is that the colloid utilizes the polyvinyl alcohol, The polyethylene glycol and the calcium chloride form a special three-dimensional structure, sealing the retained chlorine dioxide aqueous solution, avoiding the loss of chlorine dioxide, and achieving the purpose of having a long sterilization storage period in the present case.

"Embodiment 1"

An example 1 of the bactericidal rubber material of the present invention comprises 3 wt% of polyvinyl alcohol, 3 wt% of polyethylene glycol, 1 wt% of calcium chloride, 3 wt% of trisin, and 2.5 wt% of chlorine dioxide. And a total of 100% by weight of water combined with the aforementioned components.

Embodiments 2 to 13

Examples 2 and 13 are similar to Example 1, except that the amounts used or the proportions of the components are different. The actual amount of use of each component or the actual proportion of each component is shown in Table 1.

Comparative Examples 1 to 9

Comparative Examples 1 to 9 are similar to Example 1, except that the amounts used or the proportions of the respective components of the respective comparative examples are different, and some of the comparative examples are omitted, and the addition of different components is omitted. In each comparative example, the actual use amount of each component or the actual proportion of each component is shown in Table 2, respectively.

Each of the examples and each of the comparative examples were tested as follows and tested. The results are recorded in Tables 1 and 2, respectively.

Liquidity Test

A bevel having a 45-degree angle with the horizontal plane was prepared, and 1 g of the finished product of each of the examples and the comparative examples was taken as a fluidity test sample, and placed on the slope. After 5 minutes, the moving distance of the fluid sample to be tested is measured and evaluated according to the following criteria: excellent: the moving distance exceeds 5 cm

Good: moving distance is more than 4 cm, but below 5 cm

Good: moving distance is more than 3 cm, but below 4 cm

Pu: The moving distance is more than 2 cm, but below 1 cm

Poor: moving distance is more than 1 cm, but below 2 cm

Inferior: moving distance is less than 1 cm

"Bactericidal effect test"

。 Lactic acid bacteria (L-007) and P. aeruginosa (ATCC 27853) were cultured in large amounts and diluted to an OD concentration of 0.45. The bacterial solution having an OD concentration of 0.45 was serially diluted to one tenth to become a standard bacterial solution. The total weight of the diluted standard bacterial solution was 100% by weight, and 5 wt% of each of the examples and the comparative examples were allowed to stand for 7 days, and the mixture was uniformly mixed and allowed to stand for 3 hours to enable the respective examples and the comparative examples to function. . After 3 hours, the standard bacterial liquid pusher of each of the examples and the comparative examples was added, and placed in an oven at 35 ° C, and the number of colonies was measured after the culture. The number of colonies cultured by the standard bacterial solution was defined as the number of standard colonies. The number of colonies cultured in the standard bacterial solution mixed with each of the examples and the comparative examples was defined as the number of experimental colonies, and the sterilization effect was evaluated.

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Structural Stability Test

，依所算出的二氧化氯水溶液散失量，評價如下： 優：二氧化濾水溶液散失量趨近於0 Take a few examples and the comparative examples, and measure the weight before the test to obtain an original weight value. Each of the examples and the comparative examples were placed in an environment of 50 ° C for 25 hours, and each of the examples and the comparative examples were measured to obtain a post-weight value. Then, in each of the examples and comparative examples, the amount of chlorine dioxide aqueous solution lost during the test =

According to the calculated amount of chlorine dioxide aqueous solution loss, the evaluation is as follows: Excellent: the amount of loss of the aqueous solution of the dioxide filter approaches 0

Good: Loss of chlorine dioxide solution is less than 1%

Good: Loss of chlorine dioxide solution is above 1% and less than 3%

Pu: The loss of chlorine dioxide aqueous solution is more than 3% and less than 5%

Poor: Loss of chlorine dioxide solution is less than 5% and less than 7%

Inferior: the loss of chlorine dioxide solution is more than 7%

Component Compatibility Test

Each of the examples and the comparative examples were placed at room temperature for 7 days (168 hours), and if the liquid was not oozing out in each of the examples and the comparative examples, the components were evaluated to be compatible. When the volume of the liquid exuded in each of the examples and the comparative examples exceeded 1% of the volume before the test, it was evaluated as a component incompatibility.

Referring to Tables 1 and 2, it can be found from the test results of Examples 1 to 13 that when the components are within the scope of the present case, the examples are after standing for 7 days. The bactericidal effect evaluation was close to 100%, and the effect was quite good. The fluidity of each of the examples is also very good, and the user can easily apply it when using it. The finished products of the examples also have good and even excellent structural stability evaluation and component compatibility evaluation.

In Comparative Example 1 and Comparative Example 1, when the amount of polyvinyl alcohol or polyvinyl alcohol added was too small, the finished product could not effectively use hydrogen bonds to hold the aqueous chlorine dioxide solution, so the bactericidal effect was evaluated by only 50%. In Comparative Example 1 and Comparative Example 2, when the amount of polyvinyl alcohol used was too large, the components were not well compatible with each other, and the stability of the finished product was not good.

In Comparative Example 1 and Comparative Example 3, when the amount of polyethylene glycol or polyethylene glycol added was too small, the finished product could not effectively use hydrogen bonds to store the aqueous chlorine dioxide solution, so the bactericidal effect was evaluated by only 40%. Comparing Example 1 with Comparative Example 4, when the amount of polyethylene glycol used was too large, the rheological system of the colloid disintegrated, and the obtained finished product had poor structural stability, and the compatibility between the components was also not good.

Comparing Example 1 with Comparative Example 5, it can be found that when the amount of calcium chloride or calcium chloride added is too small, the finished product will not be able to effectively use the hydrogen bond to preserve the aqueous chlorine dioxide solution, so the sterilization effect is only 20%. . Comparing Example 1 with Comparative Example 6, it was found that when the amount of calcium chloride used was too large, the finished product was excessively cured, and thus the fluidity was evaluated as inferior.

Comparing Example 1 with Comparative Example 7, it was found that when the amount of use of Sanxianjiao or Sanxianjiao was too small, the fluidity of the finished product was evaluated as inferior. Comparative Example 1 As compared with Comparative Example 8, it was found that when the amount of use of Sanxianjiao was too large, the obtained finished structure was unstable and the compatibility between the components was not good.

Comparing Example 1 with Comparative Example 9, in addition to the considerable irritation to the human body, it can be found that when the amount of chlorine dioxide used is too large, the compatibility between the components is also affected, and the structure of the finished product is unstable. .

In summary, the efficacy of the sterilization glue in the present invention is that the colloid utilizes the polyvinyl alcohol, the polyethylene glycol, and the calcium chloride to seal the retained chlorine dioxide aqueous solution to avoid chlorine dioxide loss and reach This case has the purpose of a longer sterilization period.

However, the above is only the preferred embodiment of the present case. When it is not possible to limit the scope of the implementation of this case, all the simple equivalent changes and modifications made in accordance with the scope of patent application and the content of the patent specification in this case are still the patents of this case. Within the scope of coverage.

Claims (2)

A bactericidal rubber material comprising: a colloid having a total weight of the sterilizing rubber material of 100% by weight, the colloid comprising 0.5% by weight to 5% by weight of polyvinyl alcohol, 0.5% by weight to 5% by weight of polyethylene glycol, 0.5 a wt% to 5 wt% of Sanxian gum, and 0.01 wt% to 2 wt% of calcium chloride; and an aqueous chlorine dioxide solution dispersed in the colloid, the total weight of the germicidal rubber material being 100 wt%, the dioxide The aqueous chlorine solution includes 0.1% by weight to 5% by weight of chlorine dioxide, and a total of 100% by weight of water combined with other components. The sterilizing adhesive material according to claim 1, wherein the colloid forms a plurality of meshes having sizes of 60 nm to 90 nm, respectively.