TWI587033B - Contact lens product - Google Patents

Description

Contact lens products

The present invention relates to a contact lens product, and more particularly to a contact lens product that can prevent myopia or control the progression of myopia.

According to the World Health Organization (WHO), the prevalence of myopia in the world is between 8% and 62%. However, the survey in Taiwan found that the prevalence of adolescents and children under the age of 18 is as high as 85%, and the incidence of myopia is significantly higher than that. In other countries, the reason is probably due to the highly developed 3C electronic devices in recent years, which make young children's eyes prematurely accept inappropriate stimulation and cause excessive eye use. Current research shows that once young children suffer from early onset myopia, Will increase the myopia degree at a certain speed, the study also pointed out that the lower the age of myopia, the higher the probability of becoming high myopia (6.0D or higher) in the future, and the high myopia patients are more likely to cause retinal detachment, glaucoma and other serious complication. Therefore, if it is possible to detect and slow down myopia when the child is diagnosed with pseudo-myopia, it can effectively prevent the conversion of pseudo-myopia to myopia, thereby preventing the occurrence of high myopia.

The main cause of myopia is caused by the variation of the optical structure of the eyeball. The formation of optical imaging is mainly affected by the factors such as the cornea, the lens and the length of the eyeball. The eyes of normal people can focus the image correctly. A clear image is obtained on the omentum. Myopia patients may have blurred images due to excessive refractive power of the cornea and the lens (refractive myopia) or excessive axial distance (axial myopia). Myopia symptoms. The myopia symptoms of young children can be divided into myopia and pseudomyopia. Myopia is a situation in which the axial distance of the eyeball is too long to recover by correction. However, if it is pseudomyopia, it is short-term myopia of excessive force of the ciliary muscle. Symptoms are symptoms of myopia that can be corrected. There are many clinical methods for correcting false myopia in children, mainly keratoplasty and long-acting mydriatics, but the keratoplasty is easy to cause high external pressure and cause discomfort to the wearer. However, in general, long-acting mydriatics require a higher concentration of the dose to exert the effect of correcting myopia, but also relatively increase the probability of causing side effects.

It is an object of the present invention to provide a contact lens product comprising a multifocal contact lens and a buffer solution, the buffer solution comprising a specific concentration of ciliary muscle paralysis agent, whereby the multifocal contact lens provides physical correction, ciliary The muscle paralysis helps to relax the ciliary muscle, which can effectively prevent myopia or control the progression of myopia, and can avoid wearing discomfort and reduce the chance of side effects.

Another object of the present invention is to provide a contact lens product comprising a multifocal contact lens that absorbs high energy blue light, thereby reducing the chance of the retina being damaged by blue light.

According to the present invention, there is provided a contact lens product comprising a multifocal contact lens and a buffer solution, the multifocal contact lens being immersed in a buffer solution. The multifocal contact lens comprises a central zone and at least one annular zone concentrically surrounding the central zone, the diopter of the annular zone being different from the diopter of the central zone. The buffer solution comprises a ciliary muscle paralysis agent, and the concentration concentration of the ciliary muscle paralysis agent in the buffer solution is ConA, which satisfies the following condition: 0<ConA 1%.

According to the present invention there is further provided a contact lens product comprising a multifocal contact lens, wherein the composition for preparing the multifocal contact lens comprises a blue light absorbing component.

When ConA meets the above conditions, the concentration of the ciliary muscle paralysis agent is appropriate, which helps to relax the ciliary muscle and reduce the chance of side effects of the drug.

100‧‧‧Contact lens products

110, 210, 310‧‧‧ multi-focus contact lenses

111, 211, 311‧‧‧ central area

112, 212, 312‧‧‧ first ring zone

120‧‧‧buffer solution

213, 313‧‧‧ second ring zone

314‧‧‧ Third ring zone

ConA‧‧‧% concentration of ciliary muscle paralysis in buffer solution

Diameter of the central area of DiC‧‧

DiP1‧‧‧ outer ring diameter of the first annular zone

DiP2‧‧‧ outer ring diameter of the second annular zone

The outer diameter of the third annular zone of DiP3‧‧

Diopters in the central area of PowC‧‧

PowP1‧‧‧Maximum diopter of the first annular zone

Maximum diopter of the second annular zone of PowP2‧‧

Maximum diopter of the third annular zone of PowP3‧‧

The above and other objects, features, advantages and embodiments of the present invention will become more <RTIgt; <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; 2 is a plan view showing a multifocal contact lens in FIG. 1; FIG. 3 is a plan view showing a multifocal contact lens according to another embodiment of the present invention; and FIG. 4 is a view showing still another embodiment of the present invention. a schematic plan view of a multifocal contact lens; Fig. 5 is a diagram showing the relationship between the radius and the diopter of the multifocal contact lens of the first embodiment; Figure 6 is a graph showing the relationship between the radius and the diopter of the multifocal contact lens of the second embodiment; and Fig. 7 is the wavelength and light penetration of the multifocal contact lens of the second embodiment and the multifocal contact lens of the first comparative example. Fig. 8 is a graph showing the relationship between the radius and the diopter of the multifocal contact lens of the third embodiment; and Fig. 9 is a graph showing the relationship between the radius and the diopter of the multifocal contact lens of the fourth embodiment; The relationship between the wavelength and the light transmittance of the multifocal contact lens of the fourth embodiment and the multifocal contact lens of the second comparative example; and FIG. 11 is the relationship between the radius and the diopter of the multifocal contact lens of the fifth embodiment. Figure 12 is a diagram showing the relationship between the radius and the diopter of the multifocal contact lens of the sixth embodiment; Fig. 13 is the relationship between the radius and the diopter of the multifocal contact lens of the seventh embodiment; FIG. 15 is a diagram showing the relationship between the wavelength and the light transmittance of the multifocal contact lens of the embodiment and the multifocal contact lens of the third comparative example; FIG. 15 is a relationship between the radius and the diopter of the multifocal contact lens of the eighth embodiment; 16 pictures Multifocal contact lens of the ninth embodiment in relation to FIG diopter radius; 17 Photo multifocal contact lens of the tenth embodiment in relation to FIG diopter radius; Figure 18 is a graph showing the relationship between the radius and the diopter of the multifocal contact lens of the eleventh embodiment; and Fig. 19 is the wavelength and light of the multifocal contact lens of the eleventh embodiment and the multifocal contact lens of the fourth comparative example. FIG. 20 is a diagram showing the relationship between the radius and the diopter of the multifocal contact lens of the twelfth embodiment; and FIG. 21 is the multifocal contact lens of the twelfth embodiment and the fifth comparative example. A plot of wavelength versus light penetration for a multifocal contact lens.

Please refer to FIG. 1 , which is a schematic diagram of a contact lens product 100 including a multifocal contact lens 110 and a buffer solution 120 . The multifocal contact lens 110 is immersed in a buffer solution 120 according to an embodiment of the present invention. in.

Referring to FIG. 2, a plan view of the multifocal contact lens 110 in FIG. 1 is shown. The multifocal contact lens 110 includes a central region 111 and a first annular region 112 concentrically surrounding the central region 111. The diopter of the first annular region 112 is different from the diopter of the central region 111, thereby being The multifocal contact lens 110 has a multi-focus function that allows the surrounding image to be focused on the front of the retina, thereby effectively slowing the increase in the wheelbase of the eyeball and avoiding the deterioration of myopia. According to an embodiment of the invention, the diopter of the central zone 111 is fixed.

At least one of the central region 111 of the multifocal contact lens 110 and the first annular region 112 is aspherical, thereby facilitating the first annular region 212 It is counted as the diopter with a gradient gradient.

Referring to FIG. 1, the buffer solution 120 comprises a ciliary muscle paralysis agent, and the concentration concentration of the ciliary muscle paralysis agent in the buffer solution 120 is ConA, which satisfies the following condition: 0<ConA 1%. Thereby, the concentration of the ciliary muscle paralysis agent is appropriate, which helps to relax the ciliary muscle and reduce the chance of side effects of the drug. Or, it can satisfy the following conditions: 0<ConA 0.5%. Or, it can satisfy the following conditions: 0<ConA 0.25%. Or, it can satisfy the following conditions: 0<ConA 0.1%. Or, it can satisfy the following conditions: 0<ConA 0.05%. Or even, it can satisfy the following conditions: 0<ConA 0.01%. The preparation method of the buffer solution 120 may be first prepared by preparing a base solution. The base solution may be prepared by using a solution for immersing and storing contact lenses on the market, and then adding a ciliary muscle paralysis agent to the base solution to a desired concentration. In addition, there is no chemical reaction between the base solution and the ciliary muscle paralysis agent.

In accordance with the aforementioned contact lens product 100, the composition of the multifocal contact lens 110 can comprise a blue light absorbing component. Thereby, the multifocal contact lens 110 can absorb high energy blue light, thereby reducing the chance of the retina being damaged by blue light. According to an embodiment of the invention, the blue light absorbing component may be 4-(phenyldiazenyl)phenyl methacrylate.

According to the aforementioned contact lens product 100, the composition for preparing the multifocal contact lens 110 may comprise a UV (Ultraviolet) absorbing component, which may be, but not limited to, 2-[3-(2H-benzotriazol-2-yl) )-4-hydroxyphenyl]ethyl 2-methacrylic acid (2-[3-(2H-Benzotriazol-2-yl)-4-hydroxyphenyl]ethyl methacrylate), 4-methacryloxy-2-hydroxybenzophenone, 2-Phenylethyl acrylate, 2-Phenylethyl methacrylate, 2-[2-hydroxy-5-[2-(methacrylofluorene) B 2-(2'-Hydroxy-5'-Methacryloxyethylphenyl-2H-Benzotriazole) or 2-(4-benzylidene-3-hydroxyphenoxy 2-acrylate Ethyl 2-(4-Benzoyl-3-Hydroxyphenoxy) Ethyl Acrylate). Thereby, the multifocal contact lens 110 can absorb high energy UV light, thereby reducing the chance of the retina being damaged by UV light. According to an embodiment of the invention, the UV absorbing component is 2-[2-hydroxy-5-[2-(methacryloxy)ethyl]phenyl]-2H-benzotriazole, according to another embodiment of the invention For example, the UV absorbing component is 2-(4-benzoguanidino-3-hydroxyphenoxy)ethyl 2-acrylate. The aforementioned UV absorbing components may be used simultaneously or separately.

According to the aforementioned contact lens product 100, the material of the multifocal contact lens 110 can be Silicone Hydrogel, thereby effectively improving the oxygen permeability of the multifocal contact lens 110, and avoiding the red eye caused by the lack of oxygen in the cornea. , bloodshot, redness and other phenomena to provide a comfortable wear for a long time. The aforementioned hydrophobic glue may be, but is not limited to, contact lens materials classified by the US Food and Drug Administration (USFDA) to Group 5, such as Balafilcon A, Comfilcon A, Efrofilcon A, Enfilcon A, Galyfilcon A, Lotrafilcon A, Lotrafilcon B, Narafilcon A, Narafilcon B, Senofilcon A, Delefilcon A, Somofilcon A and other materials.

The composition for preparing the foregoing hydrophobic glue may comprise 2-Hydroxyethyl Methacrylate or 3-Methacryloyloxypropyltris (Trimethylsilyloxy) Silane. , 2-Hydroxy-2-methyl-propiophenone, N-Vinyl-2-Pyrrolidinone, N , N,N-Dimethyl Acrylamide, Ethylene Glycol Dimethacrylate, (3-Methylacryloxy-2-hydroxypropoxy)propyl 3-(3-Methacryloxy-2-Hydroxypropoxy)Propylbis(Trimethylsiloxy)Methylsilane, Isopropyl Alcohol, and Methacrylic Acid.

Preferably, the weight percentage of each component in the composition of the hydrophobic gel is as follows: hydroxyethyl methacrylate is 0.05% to 25%, and methacryloxypropyltris(trimethylphosphonioalkyl)decane is 0.1%~40%, 2-hydroxy-2-methyl-1-phenyl-1-propanone is 0.01%~5%, N-vinyl-2-pyrrolidone is 0.1%~35%, N,N- Dimethyl methacrylamide is 0.1% to 40%, ethylene glycol dimethacrylate is 0.01% to 5%, (3-methylpropenyloxy-2-hydroxypropoxy) propyl double (three The methyl methoxy) methyl group is 0.1% to 30%, the isopropyl alcohol is 0.1% to 30%, and the methacrylic acid is 0.01% to 5%.

More preferably, the weight percentage of each component in the composition of the hydrophobic gel is as follows: hydroxyethyl methacrylate is 0.1% to 10%, methacrylic acid The base tris(trimethylphosphonioalkyl)decane is 1% to 40%, 2-hydroxy-2-methyl-1-phenyl-1-propanone is 0.1% to 2%, N-vinyl-2- Pyrrolidone is 1% to 35%, N,N-dimethylpropenylamine is 1% to 20%, ethylene glycol dimethacrylate is 0.1% to 2%, (3-methacryloxyloxy group) The -2-hydroxypropoxy)propylbis(trimethyldecyloxy)methyl group is 1% to 30%, the isopropyl alcohol is 1% to 20%, and the methacrylic acid is 0.1% to 2%.

The composition for preparing the foregoing hydrophobic glue may comprise hydroxyethyl methacrylate, methacryloxypropyltris(trimethylphosphonioalkyl)decane, 2-hydroxy-2-methyl-1-phenyl- 1-Acetone, N-vinyl-2-pyrrolidone, N,N-dimethylpropenamide, ethylene glycol dimethacrylate, 3-ethyloxy-2-hydroxypropoxypropyl Tertiary Polydimethylsiloxane (3-Acryloxy-2-Hydroxypropoxypropyl) Terminated Polydimethylsiloxane and hexanol (1-Hexanol).

Preferably, the weight percentage of each component in the composition of the hydrophobic gel is as follows: hydroxyethyl methacrylate is 0.05% to 25%, and methacryloxypropyltris(trimethylphosphonioalkyl)decane is 0.1%~40%, 2-hydroxy-2-methyl-1-phenyl-1-propanone is 0.01%~5%, N-vinyl-2-pyrrolidone is 0.1%~35%, N,N- Dimethyl decylamine is 0.1% to 40%, ethylene glycol dimethacrylate is 0.01% to 5%, 3-ethoxycarbonyl-2-hydroxypropoxypropyl terminated polydimethyl hydrazine The oxane is 0.1% to 40% and the n-hexanol is 0.1% to 30%.

More preferably, the weight percentage of each component in the composition of the hydrophobic gel is as follows: hydroxyethyl methacrylate is 0.1% to 10%, and methacryloxypropyltris(trimethylphosphonioalkyl)decane is 1%~40%, 2-hydroxy-2-methyl-1- Phenyl-1-propanone is 0.1%~2%, N-vinyl-2-pyrrolidone is 1%~35%, N,N-dimethylpropenylamine is 1%~20%, dimethacrylic acid Ethylene glycol ester is 0.1%~2%, 3-ethoxycarbonyl-2-hydroxypropoxypropyl terminated polydimethyl methoxyalkane is 1%~40% and n-hexanol is 1%~30% .

The composition for preparing the foregoing hydrophobic glue may comprise hydroxyethyl methacrylate, methacryloxypropyltris(trimethylphosphonioalkyl)decane, 2-hydroxy-2-methyl-1-phenyl- 1-Acetone, N-vinyl-2-pyrrolidone, N,N-dimethyl decylamine, dimethyl siloxane modified urethane oligomer (Polysiloxane Macromer), methyl methacrylate (Methyl Methacrylate) and ethanol (Ethanol).

Preferably, the weight percentage of each component in the composition of the hydrophobic gel is as follows: hydroxyethyl methacrylate is 0.05% to 25%, and methacryloxypropyltris(trimethylphosphonioalkyl)decane is 0.1%~40%, 2-hydroxy-2-methyl-1-phenyl-1-propanone is 0.01%~5%, N-vinyl-2-pyrrolidone is 0.1%~35%, N,N- Dimethyl methacrylate is 0.1% to 40%, dimethyl methoxide modified urethane oligomer is 0.1% to 40%, methyl methacrylate is 0.1% to 20%, and ethanol is 0.1%. 30%.

More preferably, the weight percentage of each component in the composition of the hydrophobic gel is as follows: hydroxyethyl methacrylate is 0.1% to 10%, and methacryloxypropyltris(trimethylphosphonioalkyl)decane is 1%~40%, 2-hydroxy-2-methyl-1-phenyl-1-propanone is 0.1%~2%, N-vinyl-2-pyrrolidone is 1%~35%, N,N- Dimethyl methacrylate is 1% to 20%, dimethyl methoxy olefin modified urethane oligomer is 1% to 40%, methyl methacrylate is 1% to 10%, and ethanol is 1%. 20%.

According to an embodiment of the present invention, the composition of the water-repellent gel may further comprise a blue light absorbing component or a UV absorbing component. Preferably, the weight percentage of the blue light absorbing component or the UV absorbing component in the composition of the water repellency gel is 0.01%. ~10%, more preferably, the weight percentage of the blue light absorbing component or the UV absorbing component in the composition of the foregoing hydrophobic gel is from 0.1% to 5%.

By adjusting the ratio of each component in the hydrophobic glue, the oxygen permeability and hardness of the multifocal contact lens 110 can be effectively increased. Further, the composition of the hydrophobic gel can be added with other components as needed.

According to the contact lens product 100 described above, the material of the multifocal contact lens 110 can be a hydrogel, thereby maintaining the moist, smooth, soft and comfortable moisturizing feeling of the multifocal contact lens 110, and can be matched for a long time. Wear, avoid the foreign body sensation when wearing. The aforementioned water gel may be a contact lens material classified by the US Food and Drug Administration into the first group, that is, a low water content (less than 50% by weight) of a nonionic polymer, such as the name Helfilcon A&B, Hioxifilcon B, Mafilcon, Polymacon, Tefilcon, Tetrafilcon A and other materials. Alternatively, the aforementioned water gel may be a contact lens material classified by the US Food and Drug Administration into a second group, ie a high water content (greater than 50% by weight) of a nonionic polymer, such as the name Acofilcon A, Alfafilcon A , Hilafilcon B, Hioxifilcon A, Hioxifilcon B, Hioxifilcon D, Nelfilcon A, Nesofilcon A, Omafilcon A and Samfilcon A. Alternatively, the aforementioned water gel may be a contact lens material classified by the US Food and Drug Administration into a third group, ie, an ionic polymer having a low water content (less than 50% by weight), for example, the name is Materials such as Deltafilcon A. Alternatively, the water gel may be a fourth group of contact lens materials approved by the U.S. Food and Drug Administration, i.e., high water content (greater than 50 weight percent) of ionic polymer, such as the name Etafilcon A, Focofilcon A, Methafilcon A, Methafilcon B, Ocufilcon A, Ocufilcon B, Ocufilcon C, Ocufilcon D, Ocufilcon E, Phemfilcon A, Vifilcon A and other materials.

The composition for preparing the above water gel may comprise hydroxyethyl methacrylate, ethylene glycol dimethacrylate, 2-hydroxy-2-methyl-1-phenyl-1-propanone, glycerol (Glycerol), trishydroxyl Methylpropane trimethacrylate (1,1,1-Trimethylol Propane Trimethacrylate) and methacrylic acid.

Preferably, the weight percentage of each component in the composition of the water gel is as follows: hydroxyethyl methacrylate is 10% to 96%, ethylene glycol dimethacrylate is 0.01% to 5%, 2-hydroxy- 2-methyl-1-phenyl-1-propanone is 0.01% to 5%, glycerol is 0.1% to 30%, trimethylolpropane trimethacrylate is 0.01% to 5%, and methacrylic acid is 0.01. %~5%.

More preferably, the weight percentage of each component in the composition of the water gel is as follows: hydroxyethyl methacrylate is 40% to 96%, ethylene glycol dimethacrylate is 0.1% to 2%, and 2-hydroxy group is 2-methyl-1-phenyl-1-propanone is 0.1%~2%, glycerol is 0.1%~20%, trimethylolpropane trimethacrylate is 0.1%~2% and methacrylic acid is 0.1%. %~2%.

The composition for preparing the above water gel may comprise hydroxyethyl methacrylate, ethylene glycol dimethacrylate, 2-hydroxy-2-methyl-1-phenyl-1-propanone, glycerin, trimethylolpropane Trimethacrylate and 2-methyl-2-propane Glycerol Monomethacrylate.

Preferably, the weight percentage of each component in the composition of the water gel is as follows: hydroxyethyl methacrylate is 10% to 94.87%, ethylene glycol dimethacrylate is 0.01% to 5%, and 2-hydroxy group is 2-methyl-1-phenyl-1-propanone is 0.01% to 5%, glycerol is 0.1% to 30%, trimethylolpropane trimethacrylate is 0.01% to 5%, and 2-methyl- 2-Acetyl-2,3-dihydroxypropyl ester is 5% to 60%.

More preferably, the weight percentage of each component in the composition of the water gel is as follows: hydroxyethyl methacrylate is 40% to 79.6%, ethylene glycol dimethacrylate is 0.1% to 2%, 2-hydroxy- 2-methyl-1-phenyl-1-propanone is 0.1% to 2%, glycerol is 0.1% to 20%, trimethylolpropane trimethacrylate is 0.1% to 2%, and 2-methyl- 2-Acetyl-2,3-dihydroxypropyl ester is 20% to 50%.

The composition for preparing the above water gel may comprise hydroxyethyl methacrylate, ethylene glycol dimethacrylate, 2-hydroxy-2-methyl-1-phenyl-1-propanone, glycerin and N-vinyl- 2-pyrrolidone.

Preferably, the weight percentage of each component in the composition of the water gel is as follows: hydroxyethyl methacrylate is 10% to 96%, ethylene glycol dimethacrylate is 0.01% to 5%, 2-hydroxy- 2-methyl-1-phenyl-1-propanone is 0.01% to 5%, glycerol is 0.1% to 30%, and N-vinyl-2-pyrrolidone is 0.1% to 25%.

More preferably, the weight percentage of each component in the composition of the water gel is as follows: hydroxyethyl methacrylate is 40% to 96%, ethylene glycol dimethacrylate is 0.1% to 2%, and 2-hydroxy group is 2-methyl-1-phenyl-1-propanone 0.1%~2%, glycerin is 1%~20% and N-vinyl-2-pyrrolidone is 0.1%~10%.

According to an embodiment of the present invention, the composition of the water gel may further comprise a blue light absorbing component or a UV absorbing component. Preferably, the weight percentage of the blue light absorbing component or the UV absorbing component in the composition of the water gel is 0.01% to 10%. %, more preferably, the weight percentage of the blue light absorbing component or the UV absorbing component in the composition of the aforementioned water gel is 0.1% to 5%.

By adjusting the ratio of each component in the water gel, the water content and softness of the multifocal contact lens 110 can be effectively increased. Further, the composition of the water gel can be added with other components as needed. A monomer used in the composition of the water gel and the hydrophobic gel composition, such as hydroxyethyl methacrylate, methacrylic acid, 2-methyl-2-acrylic acid-2,3-dihydroxypropyl ester, N-vinyl -2-pyrrolidone, methacryloxypropyltris(trimethylphosphonioalkyl)decane, N,N-dimethylpropenamide, (3-methacryloxy-2-hydroxypropane Oxy)propyl group of (trimethyldecyloxy)methyl, 3-acetoxy-2-hydroxypropoxypropyl-terminated polydimethyloxane, methyl methacrylate, etc. Can be replaced with each other as needed.

Referring back to FIG. 2, the center area 111 of the multifocal contact lens 110 has a diameter DiC which satisfies the following conditions: 4 mm DiC 10mm. Thereby, according to the elastic adjustment of the pupil size in different physiological states, the central region 111 can be improved to correct the accuracy of the myopia, so that the image can be completely and clearly presented on the retina. Preferably, it satisfies the following conditions: 5 mm DiC 9mm.

The outer diameter of the first annular region 112 of the multifocal contact lens 110 is DiP1, which satisfies the following conditions: 6 mm DiP1 17mm. Thereby, the elasticity can be adjusted according to the size of the eye crack to provide a proper sense of fit of the multifocal contact lens 110, and the stability of the multifocal contact lens 110 after wearing is increased. Preferably, it satisfies the following conditions: 7 mm DiP1 15mm.

The central region 111 of the multifocal contact lens 110 has a diameter DiC, and the outer annular diameter of the first annular region 112 of the multifocal contact lens 110 is DiP1, which satisfies the following condition: 0.15 DiC/DiP1<1. Thereby, the DiC/DiP1 is appropriately sized, which is advantageous for designing an appropriate multifocal contact lens 110 according to the physiological condition of the individual eye, thereby facilitating the correction of myopia.

The central region 111 of the multifocal contact lens 110 has a diopter of PowC, which satisfies the following conditions: -6.00D PowC -0.25D. In this way, appropriate correction of myopia can be provided according to the needs of the user, thereby providing a clear image.

The maximum refractive power of the first annular region 112 of the multifocal contact lens 110 is PowP1, which satisfies the following conditions: - 5.50D PowP1 -0.50D. Thereby, the maximum refracting power of the first annular region 112 can be appropriately designed, which is advantageous for correcting myopia.

The diopter of the central region 111 of the multifocal contact lens 110 is PowC, and the maximum refracting power of the first annular region 112 of the multifocal contact lens 110 is PowP1, which satisfies the following conditions: |PowC-PowP1| 3D. Thereby, it is advantageous to correct myopia, slow down the increase of the diopter of the first annular region 112, and avoid the discomfort caused by the excessive increase of the maximum diopter. Or, it can satisfy the following conditions: |PowC-PowP1| 2D. Or, it can satisfy the following conditions: |PowC-PowP1| 1.5D. Or, it can satisfy the following conditions: |PowC-PowP1| 1D. Or, it can satisfy the following conditions: |PowC-PowP1| 0.5D. Or even, it can satisfy the following conditions: |PowC-PowP1| 0.25D.

Please refer to FIG. 3, which is a schematic plan view of a multifocal contact lens 210 in accordance with another embodiment of the present invention. The multi-focus contact lens 210 includes a central area 211, a first annular area 212, and a second annular area 213. The central area 211, the second annular area 213, and the first annular area 212 are sequentially connected from the center to the periphery and are the same center. The diameter of the central region 211 is DiC, the outer diameter of the first annular region 212 is DiP1, and the outer diameter of the second annular region 213 is DiP2, wherein the diopter of the second annular region 213 is different from the diopter of the central region 211. The diopter of the first annular zone 212 is different from the diopter of the central zone 211. Thereby, the multifocal contact lens 210 can be provided with a multi-focus function, so that the peripheral image can be focused on the front of the retina, thereby effectively slowing the increase of the wheelbase of the eyeball and avoiding the deterioration of myopia. According to an embodiment of the invention, the diopter of the central zone 211 is fixed.

At least one of the central zone 211, the first annular zone 212 and the second annular zone 213 may be aspherical, thereby facilitating the first annular zone 212 and/or the second annular zone 213 to be designed to have a gradient gradient The diopter.

The outer diameter of the second annular region 213 of the multifocal contact lens 210 is DiP2, which satisfies the following conditions: 5 mm DiP2 13mm. Thereby, the improvement of the diopter can be effectively alleviated. Preferably, it satisfies the following conditions: 6 mm DiP2 12mm.

The central portion 211 of the multifocal contact lens 210 has a diameter DiC, and the outer annular diameter of the second annular region 213 of the multifocal contact lens 210 is DiP2, which satisfies the following conditions: 0.2 DiC/DiP2<1. Thereby, the increase in the diopter of the second annular region 213 can be effectively alleviated, and the discomfort caused by the excessive increase in the diopter is reduced.

Other properties regarding multifocal contact lens 210 may be the same as multifocal contact lens 110 and will not be described again herein.

Referring to FIG. 4, a schematic plan view of a multifocal contact lens 310 including a central region 311, a first annular region 312, and a second annular region 313 is illustrated in accordance with yet another embodiment of the present invention. And the third annular zone 314, the central zone 311, the third annular zone 314, the second annular zone 313, and the first annular zone 312 are sequentially connected from the center to the periphery and are the same center, and the diameter of the central zone 311 is DiC, first The outer diameter of the annular region 312 is DiP1, the outer diameter of the second annular region 313 is DiP2, and the outer diameter of the third annular region 314 is DiP3, wherein the diopter of the third annular region 314 is different from the diopter of the central region 311. The diopter of the second annular zone 313 is different from the diopter of the central zone 311, and the diopter of the first annular zone 312 is different from the diopter of the central zone 311. Thereby, the multifocal contact lens 310 can be provided with a multi-focus function, so that the surrounding image can be focused on the front of the retina, thereby effectively slowing the increase of the wheelbase of the eyeball and avoiding the deterioration of myopia. According to an embodiment of the invention, the diopter of the central region 311 is fixed.

2 to 4, the multifocal contact lens according to the present invention can be concentrically provided with at least one annular region outside the central region (111, 211, 311) (first annular region (112, 212, 312) The second annular zone (213, 313) and the third annular zone (314)), the number of annular zones and the configuration of their diopter can be elastically adjusted to conform to the physiological condition of the individual eyeball, thereby improving the effect of correcting myopia, and being effective Prevent myopia or control the progression of myopia.

According to the present invention there is further provided a contact lens product comprising a multifocal contact lens, wherein the composition for preparing the multifocal contact lens comprises a blue light absorbing component. In this way, the multifocal contact lens absorbs high-energy blue light, which in turn reduces the chance of the retina being damaged by blue light. Regarding the blue light absorbing component, the material of the multifocal contact lens, and other details of the multifocal contact lens, reference may be made to the above-mentioned contents regarding FIGS. 1 to 4, which will not be described again.

<First Embodiment>

The multifocal contact lens of the first embodiment includes a central zone and a first annular zone, the first annular zone concentrically surrounding the central zone, and at least one of the central zone and the first annular zone is aspherical, with respect to the first implementation For the structure of the multifocal contact lens, refer to Fig. 2.

In the multifocal contact lens of the first embodiment, the diameter of the central region is DiC, the outer diameter of the first annular region is DiP1, the diopter of the central region is PowC, and the maximum diopter of the first annular region is PowP1. See Table 1 for the values of DiC, DiP1, DiC/DiP1, PowC, PowP1, |PowC-PowP1| in one embodiment.

Please refer to Table 2 and Figure 5 at the same time. Table 2 lists the radius of the multifocal contact lens of the first embodiment and its corresponding diopter. FIG. 5 is the radius and diopter of the multifocal contact lens of the first embodiment. The relationship diagram (negative value is only shown as the radius of the opposite direction), as shown in Table 2 and Figure 5, the diopter of the central zone is fixed, the diopter of the first annular zone is different from the diopter of the central zone, specifically, the first ring The diopter of the shaped area is greater than the refractive power of the central area Degree, and the diopter of the first annular zone increases as it moves away from the central zone.

The material of the multifocal contact lens of the first embodiment is water gel. For the composition of the water gel of the first embodiment, please refer to Table 3.

As can be seen from Table 3, the multifocal contact lens of the first embodiment is added by adding 2-[2-hydroxy-5-[2-(methacryloxy)ethyl]phenyl]-2H-benzotriazole. Absorbs UV light.

<Second embodiment>

The multifocal contact lens of the second embodiment comprises a central zone, a first annular zone and a second annular zone, a central zone, a second annular zone, and a first ring The shape is sequentially connected from the center to the periphery and is the same center, at least one of the central area, the second annular area and the first annular area is aspherical. For the structure of the multifocal contact lens of the second embodiment, refer to FIG. .

In the multifocal contact lens of the second embodiment, the diameter of the central region is DiC, the outer diameter of the first annular region is DiP1, the outer diameter of the second annular region is DiP2, and the diopter of the central region is PowC, first. The maximum diopter of the annular zone is PowP1, and the maximum diopter of the second annular zone is PowP2. DiC, DiP1, DiP2, DiC/DiP1, DiC/DiP2, PowC, PowP1, PowP2, |PowC-PowP1| See Table 4 for the values.

Please also refer to Table 5 and Figure 6, Table 5 lists the radius of the multifocal contact lens of the second embodiment and its corresponding diopter, and Fig. 6 shows the radius and diopter of the multifocal contact lens of the second embodiment. The relationship diagram (negative value is only shown as the radius of the opposite direction), as shown in Tables 5 and 6, the diopter of the central zone is fixed, the diopter of the second annular zone is different from the diopter of the central zone, and the diopter of the first annular zone is The diopter of the central region is different, specifically, the diopter of the second annular region is greater than the diopter of the central region, and the diopter of the second annular region increases with distance from the central region, the diopter of the first annular region is greater than the diopter of the central region, and The diopter of the first annular zone is fixed.

The material of the multifocal contact lens of the second embodiment is a water gel. For the composition of the water gel of the second embodiment, please refer to Table 6A.

As can be seen from Table 6A, the multifocal invisibility of the second embodiment is obtained by adding 2-[2-hydroxy-5-[2-(methacryloxy)ethyl]phenyl]-2H-benzotriazole. The glasses absorb UV light.

Referring to FIG. 7, which is a relationship between wavelength and light transmittance of the multifocal contact lens of the second embodiment and the multifocal contact lens of the first comparative example, the difference between the first comparative example and the second embodiment lies in The first comparative example did not add a UV absorbing component. Specifically, the first comparative example was hydroxyethyl methacrylate. Ester-substituted 2-[2-hydroxy-5-[2-(methacryloxy)ethyl]phenyl]-2H-benzotriazole, the first comparative example and the second implementation can be deduced from Fig. 7 The multi-focal contact lens of the example has a blocking rate for UV-A (UV light with a wavelength range of 316 nm to 380 nm) as follows: (1 - average wavelength of 316 to 380 nm) * 100%, and the first comparative example The blocking ratio of the multifocal contact lens of the second embodiment to UV-B (UV light having a wavelength range of 280 nm to 315 nm) is calculated as follows: (average transmittance of 1-280 nm to 315 nm) × 100%, and The results are shown in Table VIB.

As can be seen from Table 6B, compared with the first comparative example, the blocking ratio of UV-A and the blocking ratio of UV-B of the second embodiment are much larger than those of the first comparative example, in other words, the multifocal invisibility of the second embodiment. The glasses absorb UV light effectively, which in turn reduces the chance of the retina being damaged by UV light.

<Third embodiment>

The multifocal contact lens of the third embodiment comprises a central zone, a first annular zone and a second annular zone. The central zone, the second annular zone and the first annular zone are sequentially connected from the center to the periphery and are centered and centered. At least one of the region, the second annular region, and the first annular region is aspherical. For the structure of the multifocal contact lens of the third embodiment, reference may be made to FIG.

In the multifocal contact lens of the third embodiment, the diameter of the central region is DiC, the outer diameter of the first annular region is DiP1, the outer diameter of the second annular region is DiP2, and the diopter of the central region is PowC, first Ring zone The maximum diopter is PowP1, and the maximum diopter of the second annular zone is PowP2. For the values of DiC, DiP1, DiP2, DiC/DiP1, DiC/DiP2, PowC, PowP1, PowP2, |PowC-PowP1| of the third embodiment, please refer to Table VII.

Please refer to Table 8 and Figure 8 at the same time. Table 8 lists the radius of the multifocal contact lens of the third embodiment and its corresponding diopter. FIG. 8 is the radius and diopter of the multifocal contact lens of the third embodiment. The relationship diagram (negative values are only shown as the opposite direction radius distance), as shown in Tables 8 and 8, the diopter of the central zone is fixed, the diopter of the second annular zone is different from the diopter of the central zone, and the diopter of the first annular zone is The diopter of the central region is different, specifically, the diopter of the second annular region is greater than the diopter of the central region, and the diopter of the second annular region increases with distance from the central region, the diopter of the first annular region is greater than the diopter of the central region, and The diopter of the first annular zone increases as it moves away from the central zone.

The material of the multifocal contact lens of the third embodiment is water gel. For the composition of the water gel of the third embodiment, please refer to Table 9.

It can be seen from Table 9 that the multifocal contact lens of the third embodiment is added by adding 2-[2-hydroxy-5-[2-(methacryloxy)ethyl]phenyl]-2H-benzotriazole. Absorbs UV light.

<Fourth embodiment>

The multifocal contact lens of the fourth embodiment includes a central zone and a first annular zone, the first annular zone concentrically surrounding the central zone, and at least one of the central zone and the first annular zone is aspherical, with respect to the fourth implementation For the structure of the multifocal contact lens, refer to Fig. 2.

In the multifocal contact lens of the fourth embodiment, the diameter of the central region is DiC, the outer diameter of the first annular region is DiP1, the diopter of the central region is PowC, and the maximum diopter of the first annular region is PowP1. For the values of DiC, DiP1, DiC/DiP1, PowC, PowP1, |PowC-PowP1| of the four embodiments, see Table 10.

Please refer to Table 11 and Figure 9 at the same time. Table 11 lists the radius of the multifocal contact lens of the fourth embodiment and its corresponding diopter (negative values are only indicated as the opposite direction radius distance), and Figure 9 is the According to the relationship between the radius of the multifocal contact lens and the diopter of the fourth embodiment, as shown in Tables 11 and 9, the diopter of the central region is fixed, and the diopter of the first annular region is different from the diopter of the central region, specifically, The diopter of the first annular zone is greater than the diopter of the central zone, and the diopter of the first annular zone increases as it moves away from the central zone.

The material of the multifocal contact lens of the fourth embodiment is water gel. For the composition of the water gel of the fourth embodiment, please refer to Table 12A.

As can be seen from Table 12A, the multifocal contact lens of the fourth embodiment can absorb UV light by adding 2-(4-benzylidene-3-hydroxyphenoxy)ethyl 2-acrylate.

Referring to FIG. 10, which is a relationship between wavelength and light transmittance of the multifocal contact lens of the fourth embodiment and the multifocal contact lens of the second comparative example, the difference between the second comparative example and the fourth embodiment lies in In the second comparative example, the UV absorbing component was not added. Specifically, the second comparative example replaced 2-(4-benzopyridin-3-hydroxyphenoxy)ethyl 2-acrylate with hydroxyethyl methacrylate. Fig. 10 can infer the blocking ratio of the second comparative example and the fourth embodiment of the multifocal contact lens for UV-A (UV light having a wavelength range of 316 nm to 380 nm), and the calculation method is as follows: (1 - wavelength 316 to 380 nm The average transmittance is *100%, and the blocking ratio of the second comparative example and the fourth embodiment of the multifocal contact lens for UV-B (UV light having a wavelength range of 280 nm to 315 nm) is calculated as follows: (1-280 nm) The average transmittance of ~315 nm was ×100%, and the results are shown in Table 12B.

As can be seen from Table 12B, compared with the second comparative example, the blocking ratio of UV-A and the blocking ratio of UV-B of the fourth embodiment are much larger than those of the second comparative example, in other words, the multi-focus of the fourth embodiment. Contact lenses can be effectively absorbed UV light, which in turn reduces the chance of the retina being damaged by UV light.

<Fifth Embodiment>

The multifocal contact lens of the fifth embodiment comprises a central zone, a first annular zone and a second annular zone. The central zone, the second annular zone and the first annular zone are sequentially connected from the center to the periphery and are centered and centered. At least one of the region, the second annular region, and the first annular region is aspherical. For the structure of the multifocal contact lens of the fifth embodiment, reference may be made to FIG.

In the multifocal contact lens of the fifth embodiment, the diameter of the central region is DiC, the outer diameter of the first annular region is DiP1, the outer diameter of the second annular region is DiP2, and the diopter of the central region is PowC, first The maximum diopter of the annular zone is PowP1, and the maximum diopter of the second annular zone is PowP2. For the fifth embodiment, DiC, DiP1, DiP2, DiC/DiP1, DiC/DiP2, PowC, PowP1, PowP2, |PowC-PowP1| See Table 13 for the values.

Please refer to Table 14 and FIG. 11 at the same time. Table 14 lists the radius of the multifocal contact lens of the fifth embodiment and its corresponding refracting power, and FIG. 11 is the radius of the multifocal contact lens of the fifth embodiment. The relationship of diopter (negative value is only shown as the radius of the opposite direction), as shown in Tables 14 and 11, the diopter of the central zone is fixed, the diopter of the second annular zone is different from the diopter of the central zone, and the first annular zone The diopter is different from the diopter in the central region. Specifically, the diopter of the second annular region is greater than the diopter of the central region. And the diopter of the second annular zone increases with distance from the central zone, the diopter of the first annular zone is greater than the diopter of the central zone, and the diopter of the first annular zone is fixed.

The material of the multifocal contact lens of the fifth embodiment is a water gel. For the composition of the water gel of the fifth embodiment, refer to Table 15.

As apparent from Table 15, the multifocal contact lens of the fifth embodiment can absorb UV light by adding 2-(4-benzylidene-3-hydroxyphenoxy)ethyl 2-acrylate.

<Sixth embodiment>

The multifocal contact lens of the sixth embodiment includes a central zone and a first annular zone, the first annular zone concentrically surrounding the central zone, and at least one of the central zone and the first annular zone is aspherical, with respect to the sixth implementation For the structure of the multifocal contact lens, refer to Fig. 2.

In the multifocal contact lens of the sixth embodiment, the diameter of the central region is DiC, the outer diameter of the first annular region is DiP1, the diopter of the central region is PowC, and the maximum diopter of the first annular region is PowP1. For the values of DiC, DiP1, DiC/DiP1, PowC, PowP1, |PowC-PowP1| of the six embodiments, see Table 16.

Please refer to Table 17 and Figure 12 at the same time. Table 17 lists the radius of the multifocal contact lens of the sixth embodiment and its corresponding refracting power, and FIG. 12 is the radius of the multifocal contact lens of the sixth embodiment. The relationship of diopter (negative value is only shown as the radial distance in the opposite direction). It can be seen from Tables 17 and 12 that the diopter of the central region is fixed, and the diopter of the first annular region is different from the diopter of the central region. Specifically, The diopter of the first annular zone is greater than the diopter of the central zone, and the diopter of the first annular zone increases as it moves away from the central zone.

The material of the multifocal contact lens of the sixth embodiment is a water gel. For the composition of the water gel of the sixth embodiment, refer to Table 18.

As apparent from Table 18, the multifocal contact lens of the sixth embodiment can absorb UV light by adding 2-(4-benzoguanidino-3-hydroxyphenoxy)ethyl 2-acrylate.

<Seventh embodiment>

The multifocal contact lens of the seventh embodiment comprises a central zone, a first annular zone and a second annular zone. The central zone, the second annular zone and the first annular zone are sequentially connected from the center to the periphery and are centered and centered. At least one of the region, the second annular region, and the first annular region is aspherical. For the structure of the multifocal contact lens of the seventh embodiment, reference may be made to FIG.

In the multifocal contact lens of the seventh embodiment, the diameter of the central region is DiC, the outer diameter of the first annular region is DiP1, the outer diameter of the second annular region is DiP2, and the diopter of the central region is PowC, first The maximum diopter of the annular zone is PowP1, and the maximum diopter of the second annular zone is PowP2, regarding the values of DiC, DiP1, DiP2, DiC/DiP1, DiC/DiP2, PowC, PowP1, PowP2, |PowC-PowP1| of the seventh embodiment, see Table 19.

Please refer to Table 20 and Figure 13 at the same time. Table 20 lists the radius of the multifocal contact lens of the seventh embodiment and its corresponding diopter. FIG. 13 is the radius of the multifocal contact lens of the seventh embodiment. The relationship of diopter (negative value is only shown as the radius of the opposite direction). It can be seen from Tables 20 and 13 that the diopter of the central zone is fixed, the diopter of the second annular zone is different from the diopter of the central zone, and the first annular zone is different. The diopter is different from the diopter of the central region. Specifically, the diopter of the second annular region is greater than the diopter of the central region, and the diopter of the second annular region increases with distance from the central region, and the diopter of the first annular region is greater than that of the central region. The diopter, and the diopter of the first annular zone increases as it moves away from the central zone.

The material of the multifocal contact lens of the seventh embodiment is water gel. For the composition of the water gel of the seventh embodiment, please refer to Table 21A.

As can be seen from Table 21A, the multifocal contact lens of the seventh embodiment can absorb blue light by adding tetraphenyldimethacrylic acid.

Referring to FIG. 14, which is a relationship between the wavelength and the light transmittance of the multifocal contact lens of the seventh embodiment and the multifocal contact lens of the third comparative example, the difference between the third comparative example and the seventh embodiment lies in In the third comparative example, the blue light absorbing component was not added. Specifically, the third comparative example replaced tetraphenyl dimethacrylic acid with hydroxyethyl methacrylate, and the third comparative example and the seventh embodiment were deduced from FIG. The multi-focus contact lens for the blue light (wavelength range 380nm ~ 495nm) blocking rate, the calculation method is as follows: (1-wavelength 380 ~ 495nm average transmittance) * 100%, and the results are listed in Table 21 B.

As can be seen from Table 21B, compared with the third comparative example, the blocking ratio of the blue light in the seventh embodiment is much larger than that in the third comparative example. In other words, the multifocal contact lens of the seventh embodiment can effectively absorb blue light, and thus can be effectively absorbed. Reduces the chance of the retina being damaged by blue light.

<Eighth Embodiment>

The multifocal contact lens of the eighth embodiment includes a central zone and a first annular zone, the first annular zone concentrically surrounding the central zone, and at least one of the central zone and the first annular zone is aspherical, with respect to the eighth implementation For the structure of the multifocal contact lens, refer to Fig. 2.

In the multifocal contact lens of the eighth embodiment, the diameter of the central region is DiC, the outer diameter of the first annular region is DiP1, the diopter of the central region is PowC, and the maximum diopter of the first annular region is PowP1. See Table 22 for the values of DiC, DiP1, DiC/DiP1, PowC, PowP1, |PowC-PowP1| in the eighth embodiment.

Please also refer to Table 23 and Figure 15, which lists the radius of the multifocal contact lens of the eighth embodiment and its corresponding diopter, and Fig. 15 shows the multifocal contact lens of the eighth embodiment. The relationship between radius and diopter (negative value is only indicated as the radius of the opposite direction). It can be seen from Tables 23 and 15 that the diopter of the central zone is fixed, and the diopter of the first annular zone is different from the diopter of the central zone. In other words, the diopter of the first annular zone is greater than the diopter of the central zone, and the diopter of the first annular zone increases as it moves away from the central zone.

The material of the multifocal contact lens of the eighth embodiment is a water gel. For the composition of the water gel of the eighth embodiment, please refer to Table 24.

As can be seen from Table 24, the multifocal contact lens of the eighth embodiment can absorb blue light by adding tetraphenyldimethacrylic acid.

<Ninth embodiment>

The multifocal contact lens of the ninth embodiment includes a central zone, a first annular zone, and a second annular zone. The central zone, the second annular zone, and the first annular zone are sequentially connected from the center to the periphery and are centered and centered. At least one of the region, the second annular region, and the first annular region is aspherical, and the structure of the multifocal contact lens of the ninth embodiment can be referred to FIG.

In the multifocal contact lens of the ninth embodiment, the central portion is straight The diameter is DiC, the outer diameter of the first annular zone is DiP1, the outer diameter of the second annular zone is DiP2, the diopter of the central zone is PowC, the maximum diopter of the first annular zone is PowP1, and the second annular zone is of PowP1. The maximum diopter is PowP2, and the values of DiC, DiP1, DiP2, DiC/DiP1, DiC/DiP2, PowC, PowP1, PowP2, |PowC-PowP1| of the ninth embodiment are shown in Table 25.

Please also refer to Table 26 and Figure 16, which lists the radius of the multifocal contact lens of the ninth embodiment and its corresponding diopter, and Fig. 16 shows the multifocal contact lens of the ninth embodiment. The relationship between radius and diopter (negative value is only indicated as the radius of the opposite direction). It can be seen from Tables 26 and 16 that the diopter of the central zone is fixed, and the diopter of the second annular zone is different from the diopter of the central zone. The diopter of the annular zone is different from the diopter of the central zone. Specifically, the diopter of the second annular zone is greater than the diopter of the central zone, and the diopter of the second annular zone increases with distance from the central zone, and the diopter of the first annular zone is greater than The diopter of the central zone, and the diopter of the first annular zone increases as it moves away from the central zone.

The material of the multifocal contact lens of the ninth embodiment is a water gel. For the composition of the water gel of the ninth embodiment, please refer to Table 27.

As can be seen from Table 27, the multifocal contact lens of the ninth embodiment can absorb blue light by adding tetraphenyldimethacrylic acid.

<Tenth embodiment>

The multifocal contact lens of the tenth embodiment includes a central zone and a first annular zone, the first annular zone concentrically surrounding the central zone, and at least one of the central zone and the first annular zone is aspherical, with respect to the tenth implementation For the structure of the multifocal contact lens, refer to Fig. 2.

In the multifocal contact lens of the tenth embodiment, the diameter of the central region is DiC, the outer diameter of the first annular region is DiP1, the diopter of the central region is PowC, and the maximum diopter of the first annular region is PowP1. See Table 28 for the values of DiC, DiP1, DiC/DiP1, PowC, PowP1, |PowC-PowP1| of the ten embodiment.

Please also refer to Table 29 and Table 17, which lists the radius of the multifocal contact lens of the tenth embodiment and its corresponding refracting power, and FIG. 17 shows the multifocal contact lens of the tenth embodiment. The relationship between radius and diopter (negative value is only indicated as the radius of the opposite direction). It can be seen from Tables 29 and 17 that the diopter of the central zone is fixed, and the diopter of the first annular zone is different from the diopter of the central zone. In other words, the diopter of the first annular zone is greater than the diopter of the central zone, and the diopter of the first annular zone increases as it moves away from the central zone.

The material of the multifocal contact lens of the tenth embodiment is a hydrophobic glue. For the composition of the water-repellent gel of the tenth embodiment, please refer to Table 30.

As can be seen from Table 30, the multifocal contact lens of the tenth embodiment can absorb UV light by adding 2-(4-benzoguanidino-3-hydroxyphenoxy)ethyl acrylate.

<Eleventh Embodiment>

The multifocal contact lens of the eleventh embodiment comprises a central zone, a first annular zone and a second annular zone, wherein the central zone, the second annular zone and the first annular zone are sequentially connected from the center to the periphery and are the same center. At least one of the central zone, the second annular zone, and the first annular zone is aspherical. For the structure of the multifocal contact lens of the eleventh embodiment, reference may be made to FIG.

In the multifocal contact lens of the eleventh embodiment, the diameter of the central region is DiC, the outer diameter of the first annular region is DiP1, the outer diameter of the second annular region is DiP2, and the diopter of the central region is PowC, The maximum diopter of an annular zone is PowP1, and the maximum diopter of the second annular zone is PowP2. For the eleventh embodiment, DiC, DiP1, DiP2, DiC/DiP1, DiC/DiP2, PowC, PowP1, PowP2, |PowC- See Table 31 for the values of PowP1|.

Please refer to Table 32 and Figure 18 simultaneously. Table 32 shows the radius of the multifocal contact lens of the eleventh embodiment and the corresponding dioptric power. FIG. 18 is the multifocal invisibility of the eleventh embodiment. The relationship between the radius of the glasses and the diopter (negative values are only shown as the radial distance in the opposite direction). As can be seen from Tables 32 and 18, the diopter of the central zone is fixed, and the diopter of the second annular zone is different from the diopter of the central zone. The diopter of the first annular zone is different from the diopter of the central zone. Specifically, the diopter of the second annular zone is greater than the diopter of the central zone, and the diopter of the second annular zone increases with distance from the central zone, the first annular zone The diopter is greater than the diopter of the central zone, and the diopter of the first annular zone increases as it moves away from the central zone.

The material of the multifocal contact lens of the eleventh embodiment is a hydrophobic glue. For the composition of the water-repellent gel of the eleventh embodiment, refer to Table 33A.

As can be seen from Table 33A, the multifocal contact lens of the eleventh embodiment can absorb UV light by adding 2-(4-benzylidene-3-hydroxyphenoxy)ethyl 2-acrylate.

Referring to FIG. 19, which is a relationship between wavelength and light transmittance of the multifocal contact lens of the eleventh embodiment and the multifocal contact lens of the fourth comparative example, the fourth comparative example and the eleventh embodiment The difference is that the fourth comparative example does not add a UV absorbing component. Specifically, the fourth comparative example replaces 2-(4-benzoguanidino-3-hydroxyphenoxy)ethyl 2-acrylate with hydroxyethyl methacrylate. From Fig. 19, the blocking ratio of the multi-focal contact lens of the fourth comparative example and the eleventh embodiment for UV-A (UV light having a wavelength range of 316 nm to 380 nm) can be deduced, and the calculation method is as follows: (1-wavelength 316) The average transmittance of ~380 nm)*100%, and the blocking ratio of the fourth comparative example and the multifocal contact lens of the eleventh embodiment for UV-B (UV light having a wavelength range of 280 nm to 315 nm) are calculated as follows: (Average transmittance of 1-280 nm to 315 nm) × 100%, and the results are shown in Table 33B.

As can be seen from Table 33B, compared with the fourth comparative example, the tenth The blocking rate of UV-A and the blocking rate of UV-B of an embodiment are much larger than that of the fourth comparative example. In other words, the multifocal contact lens of the eleventh embodiment can effectively absorb UV light, thereby reducing the retinal UV light. The probability of injury.

<Twelfth Embodiment>

The multifocal contact lens of the twelfth embodiment comprises a central zone, a first annular zone, a second annular zone and a third annular zone, wherein the central zone, the third annular zone, the second annular zone, and the first annular zone are comprised of The center to the periphery are sequentially connected and are the same center, at least one of the central area, the third annular area, the second annular area and the first annular area is aspherical. For the structure of the twelfth embodiment multifocal contact lens, reference may be made to Figure 4.

In the multifocal contact lens of the twelfth embodiment, the diameter of the central portion is DiC, the outer diameter of the first annular region is DiP1, the outer diameter of the second annular region is DiP2, and the outer diameter of the third annular region is For DiP3, the central region has a diopter of PowC, the first annular region has a maximum diopter of PowP1, the second annular region has a maximum diopter of PowP2, and the third annular region has a maximum diopter of PowP3. Regarding the DiC of the twelfth embodiment, See Table 34 for the values of DiP1, DiP2, DiP3, DiC/DiP1, DiC/DiP2, PowC, PowP1, PowP2, PowP3, and |PowC-PowP1|.

Please also refer to Table 35 and Figure 20, Table 35 shows the radius of the multifocal contact lens of the twelfth embodiment and its corresponding flexion Luminosity, Fig. 20 is a graph showing the relationship between the radius and the diopter of the multifocal contact lens of the twelfth embodiment (the negative value is only shown as the radius of the opposite direction), and the diopter of the central region is known from Tables 35 and 20 Fixed, the diopter of the third annular zone is different from the diopter of the central zone, the diopter of the second annular zone is different from the diopter of the central zone, and the diopter of the first annular zone is different from the diopter of the central zone, specifically, the third annular zone The diopter is greater than the diopter of the central region, and the diopter of the third annular region increases with distance from the central region, the diopter of the second annular region is greater than the diopter of the central region, and the diopter of the second annular region increases with distance from the central region, first The diopter of the annular zone is greater than the diopter of the central zone, and the diopter of the first annular zone is fixed.

The material of the twelfth embodiment of the multifocal contact lens is a hydrophobic glue. For the composition of the water gel of the twelfth embodiment, please refer to Table 36A.

As can be seen from Table 36A, the multifocal contact lens of the twelfth embodiment can absorb blue light by adding tetraphenyldimethacrylic acid.

Please refer to FIG. 21, which is a relationship between wavelength and light transmittance of the multifocal contact lens of the twelfth embodiment and the multifocal contact lens of the fifth comparative example, and the fifth comparative example and the twelfth embodiment The difference is that the fifth comparative example does not add a blue light absorbing component. Specifically, the fifth comparative example replaces tetraphenyl dimethacrylic acid with hydroxyethyl methacrylate, and the fifth comparative example and the tenth can be deduced from FIG. 21 The blocking ratio of the multifocal contact lens of the second embodiment for blue light (wavelength range 380 nm to 495 nm) is calculated as follows: (1 - average transmittance of wavelength 380 to 495 nm) * 100%, and the results are listed in Table 30. Six B.

As can be seen from Table 36B, compared with the fifth comparative example, the blocking ratio of the twelfth embodiment to blue light is much larger than that of the fifth comparative example. In other words, the multifocal contact lens of the twelfth embodiment can effectively absorb blue light. In turn, the chance of the retina being damaged by blue light is reduced.

The aspherical surface on the multifocal contact lens of the present invention means a curved surface shape of the front or back surface under the over center profile, wherein the front surface refers to the surface away from the cornea of the eyeball, and the back surface refers to the surface near the cornea of the eyeball.

The diopter in the present invention is represented by a D value, and when the lens diopter for correcting myopia is a negative value, the diopter of the corrected far vision lens is a positive value.

The ciliary muscle paralysis agent of the present invention includes, but is not limited to, Atropine ((3-endo)-8-Methyl-8-azabicyclo[3.2.1] oct-3-yl tropate), Toppicamide; N-Ethyl-3-hydroxy-2-phenyl-N-(4-pyridinylmethyl)propanamide), Cyclopentolate; 2-(Dimethylamino)ethyl(1-hydroxycyclopentyl)(phenyl)acetate, (Homatropine; (3-endo)-8-Methyl-8-azabicyclo[3.2.1] oct-3-yl hydroxy(phenyl)acetate), scopolamine (Sropolamine; (1R, 2R, 4S, 5S, 7s)- 9-Methyl-3-oxa-9-azatricyclo[3.3.1.0 ^2,4 ]non-7-yl(2S)-3-hydroxy-2-phenylpropanoate) with Eucatropine (1,2,2, 6-Tetramethyl-4-piperidinyl hydroxy(phenyl)acetate) and salts of the foregoing. Ciliary muscle paralysis agent, also known as a dilated sputum, is a parasympathetic blocker, which is a non-selective M-type muscarinic blocker, which can block muscarinic receptors. The ciliary muscles that control the pupil are paralyzed and relaxed, which in turn enlarges the pupil.

While the present invention has been disclosed in the above embodiments, it is not intended to limit the invention, and the invention may be modified and modified in various ways without departing from the spirit and scope of the invention. The scope is subject to the definition of the scope of the patent application.

100‧‧‧Contact lens products

110‧‧‧Multifocal contact lenses

120‧‧‧buffer solution

Claims (48)

A contact lens product comprising: a multifocal contact lens comprising: a central region; and at least one annular region concentrically surrounding the central region, the diopter of the annular region being different from the diopter of the central region; and a buffer solution, the buffer The multifocal contact lens is immersed in the buffer solution, the buffer solution comprising a ciliary muscle paralysis agent, wherein the concentration concentration of the ciliary muscle paralysis agent in the buffer solution is ConA, which satisfies the following condition: 0<ConA 1%. The contact lens product according to claim 1, wherein the concentration of the ciliary muscle paralysis agent in the buffer solution is ConA, which satisfies the following condition: 0<ConA 0.5%. The contact lens product according to claim 2, wherein the concentration of the ciliary muscle paralysis agent in the buffer solution is ConA, which satisfies the following condition: 0<ConA 0.25%. The contact lens product according to claim 3, wherein the concentration of the ciliary muscle paralysis agent in the buffer solution is ConA, which satisfies the following condition: 0<ConA 0.1%. The contact lens product according to claim 4, wherein the concentration of the ciliary muscle paralysis agent in the buffer solution is ConA, which satisfies the following condition: 0<ConA 0.05%. The contact lens product of claim 1, wherein the composition for preparing the multifocal contact lens comprises a blue light absorbing component. The contact lens product of claim 6, wherein the blue light absorbing component is 4-(phenyldiazenyl)phenyl methacrylate. The contact lens product of claim 1, wherein the composition for preparing the multifocal contact lens comprises a UV (Ultraviolet) absorbing component. The contact lens product of claim 8, wherein the UV absorbing component is 2-[2-hydroxy-5-[2-(methacryloxy)ethyl]phenyl]-2H-benzo Triazole or 2-(4-benzoguanidino-3-hydroxyphenoxy)ethyl 2-acrylate. The contact lens product of claim 1, wherein the multifocal contact lens is made of hydrophobic glue. The contact lens product according to claim 10, wherein the composition for preparing the hydrophobic gel comprises hydroxyethyl methacrylate, methacryloxypropyltris(trimethylphosphonioalkyl)decane, 2-hydroxy-2-methyl-1-phenyl-1-propanone, N-vinyl-2-pyrrolidone, N,N-dimethyl decylamine, ethylene glycol dimethacrylate, (3 -Methethyloxy-2-hydroxypropoxy)propylbis(trimethyldecyloxy)methyl, isopropanol and methacrylic acid. Contact lens as claimed in claim 10 a product, wherein the composition for preparing the hydrophobic gel comprises hydroxyethyl methacrylate, methacryloxypropyltris(trimethylphosphonioalkyl)decane, 2-hydroxy-2-methyl-1-benzene 1-acetone, N-vinyl-2-pyrrolidone, N,N-dimethylpropenamide, ethylene glycol dimethacrylate, 3-ethyloxy-2-hydroxypropoxypropane Base-terminated polydimethyl siloxane and n-hexanol. The contact lens product according to claim 10, wherein the composition for preparing the hydrophobic gel comprises hydroxyethyl methacrylate, methacryloxypropyltris(trimethylphosphonioalkyl)decane, 2-hydroxy-2-methyl-1-phenyl-1-propanone, N-vinyl-2-pyrrolidone, N,N-dimethylpropenylamine, dimethyloxane modified urethane oligo Polymer, methyl methacrylate and ethanol. The contact lens product of claim 1, wherein the multifocal contact lens is made of water glue. The contact lens product of claim 14, wherein the composition for preparing the water gel comprises hydroxyethyl methacrylate, ethylene glycol dimethacrylate, 2-hydroxy-2-methyl-1- Phenyl-1-propanone, glycerin, trimethylolpropane trimethacrylate, and methacrylic acid. The contact lens product of claim 14, wherein the composition for preparing the water gel comprises hydroxyethyl methacrylate, ethylene glycol dimethacrylate, 2-hydroxy-2-methyl-1- Phenyl-1-propanone, glycerin, trimethylolpropane trimethacrylate, and 2-methyl-2-acrylic acid-2,3-dihydroxypropyl ester. The contact lens product of claim 14, wherein the composition for preparing the water gel comprises hydroxyethyl methacrylate, ethylene glycol dimethacrylate, 2-hydroxy-2-methyl-1- Phenyl-1-propanone, Glycerin and N-vinyl-2-pyrrolidone. The contact lens product of claim 1, wherein the number of the annular regions of the multifocal contact lens is two, respectively a first annular region and a second annular region, the central region, the first a second annular region, the first annular region is sequentially connected from the center to the periphery and is the same center, the diopter of the second annular region is different from the diopter of the central region, and the central region, the second annular region, the first At least one of the annular regions is aspherical. The contact lens product of claim 18, wherein the central portion of the multifocal contact lens has a diameter of DiC, which satisfies the following condition: 4 mm DiC 10mm. The contact lens product of claim 18, wherein the outer circumference of the first annular region of the multifocal contact lens has a diameter of DiP1, which satisfies the following condition: 6 mm DiP1 17mm. The contact lens product of claim 18, wherein the outer annular diameter of the second annular region of the multifocal contact lens is DiP2, which satisfies the following condition: 5 mm DiP2 13mm. The contact lens product of claim 18, wherein the central region of the multifocal contact lens has a diameter DiC, and the outer annular diameter of the first annular region of the multifocal contact lens is DiP1, which satisfies The following conditions: 0.15 DiC/DiP1<1. The contact lens product of claim 18, wherein the central region of the multifocal contact lens has a diameter DiC, and the outer annular diameter of the second annular region of the multifocal contact lens is DiP2, which satisfies the following Condition: 0.2 DiC/DiP2<1. The contact lens product of claim 18, wherein the central region of the multifocal contact lens has a diopter of PowC, and the maximum refractive power of the first annular region of the multifocal contact lens is PowP1, which satisfies the following Condition: |PowC-PowP1| 3D. A contact lens product comprising: a multifocal contact lens; wherein the composition for preparing the multifocal contact lens comprises a blue light absorbing component, the material of the multifocal contact lens is a hydrophobic glue, and the composition for preparing the hydrophobic adhesive comprises a Hydroxyethyl acrylate, methacryloxypropyltris(trimethylphosphonioalkyl)decane, 2-hydroxy-2-methyl-1-phenyl-1-propanone, N-vinyl-2- Pyrrolidone, N,N-dimethylpropenamide, ethylene glycol dimethacrylate, (3-methylpropenyloxy-2-hydroxypropoxy)propyl bis(trimethyldecyloxy) ) methyl, isopropanol and methacrylic acid. The contact lens product of claim 25, wherein the blue light absorbing component is tetraphenyldimethacrylic acid. The contact lens product of claim 25, wherein the multifocal contact lens comprises: a central zone; and at least one annular zone concentrically surrounding the central zone, the diopter of the annular zone being different from the diopter of the central zone And the central area and the annular area are One less is aspheric. The contact lens product of claim 27, wherein the annular zone is a first annular zone, the central zone has a diopter of PowC, and the maximum refractive power of the first annular zone is PowP1, which satisfies the following conditions :|PowC-PowP1| 3D. A contact lens product comprising: a multifocal contact lens; wherein the composition for preparing the multifocal contact lens comprises a blue light absorbing component, the material of the multifocal contact lens is a hydrophobic glue, and the composition for preparing the hydrophobic adhesive comprises a Hydroxyethyl acrylate, methacryloxypropyltris(trimethylphosphonioalkyl)decane, 2-hydroxy-2-methyl-1-phenyl-1-propanone, N-vinyl-2- Pyrrolidone, N,N-dimethylpropenamide, ethylene glycol dimethacrylate, 3-ethyloxy-2-hydroxypropoxypropyl terminated polydimethyloxane and n-hexanol . The contact lens product of claim 29, wherein the blue light absorbing component is tetraphenyldimethacrylic acid. The contact lens product of claim 29, wherein the multifocal contact lens comprises: a central region; and at least one annular region concentrically surrounding the central region, the refractive power of the annular region being different from the diopter of the central region And at least one of the central zone and the annular zone is aspherical. The contact lens product of claim 31, wherein the annular zone is a first annular zone, the central zone has a diopter of PowC, and the maximum refractive power of the first annular zone is PowP1, which satisfies the following conditions :|PowC-PowP1| 3D. A contact lens product comprising: a multifocal contact lens; wherein the composition for preparing the multifocal contact lens comprises a blue light absorbing component, the material of the multifocal contact lens is a hydrophobic glue, and the composition for preparing the hydrophobic adhesive comprises a Hydroxyethyl acrylate, methacryloxypropyltris(trimethylphosphonioalkyl)decane, 2-hydroxy-2-methyl-1-phenyl-1-propanone, N-vinyl-2- Pyrrolidone, N,N-dimethylpropenylamine, dimethyloxane modified urethane oligomer, methyl methacrylate, and ethanol. The contact lens product of claim 33, wherein the blue light absorbing component is tetraphenyldimethacrylic acid. The contact lens product of claim 33, wherein the multifocal contact lens comprises: a central zone; and at least one annular zone concentrically surrounding the central zone, the diopter of the annular zone being different from the diopter of the central zone And at least one of the central zone and the annular zone is aspherical. The contact lens product of claim 35, wherein the annular zone is a first annular zone, the central zone has a diopter of PowC, and the maximum refractive power of the first annular zone is PowP1, which satisfies the following conditions :|PowC-PowP1| 3D. A contact lens product comprising: a multifocal contact lens; wherein the composition for preparing the multifocal contact lens comprises a blue light absorbing component, the multifocal contact lens is made of water gel, and the composition for preparing the water gel comprises hydroxyethyl methacrylate and dimethyl Ethylene glycol acrylate, 2-hydroxy-2-methyl-1-phenyl-1-propanone, glycerin, trimethylolpropane trimethacrylate, and methacrylic acid. The contact lens product of claim 37, wherein the blue light absorbing component is tetraphenyldimethacrylic acid. The contact lens product of claim 37, wherein the multifocal contact lens comprises: a central region; and at least one annular region concentrically surrounding the central region, the diopter of the annular region being different from the diopter of the central region And at least one of the central zone and the annular zone is aspherical. The contact lens product of claim 39, wherein the annular zone is a first annular zone, the central zone has a diopter of PowC, and the maximum refractive power of the first annular zone is PowP1, which satisfies the following conditions :|PowC-PowP1| 3D. A contact lens product comprising: a multifocal contact lens; wherein the composition for preparing the multifocal contact lens comprises a blue light absorbing component, the multifocal contact lens is made of water gel, and the composition for preparing the water gel comprises methacrylic acid Hydroxyethyl ester, ethylene glycol dimethacrylate, 2-hydroxy-2-methyl-1-phenyl-1-propanone, glycerol, trimethylolpropane trimethyl propyl The enoate and the 2,3-dihydroxypropyl 2-methyl-2-acrylate. The contact lens product of claim 41, wherein the blue light absorbing component is tetraphenyldimethacrylic acid. The contact lens product of claim 41, wherein the multifocal contact lens comprises: a central region; and at least one annular region concentrically surrounding the central region, the refractive power of the annular region being different from the diopter of the central region And at least one of the central zone and the annular zone is aspherical. The contact lens product of claim 43, wherein the annular zone is a first annular zone, the central zone has a diopter of PowC, and the maximum refractive power of the first annular zone is PowP1, which satisfies the following conditions :|PowC-PowP1| 3D. A contact lens product comprising: a multifocal contact lens; wherein the composition for preparing the multifocal contact lens comprises a blue light absorbing component, the multifocal contact lens is made of water gel, and the composition for preparing the water gel comprises methacrylic acid Hydroxyethyl ester, ethylene glycol dimethacrylate, 2-hydroxy-2-methyl-1-phenyl-1-propanone, glycerol, and N-vinyl-2-pyrrolidone. The contact lens product of claim 45, wherein the blue light absorbing component is tetraphenyldimethacrylic acid. The contact lens product of claim 45, wherein the multifocal contact lens comprises: a central zone; and at least one annular zone concentrically surrounding the central zone, the diopter of the annular zone being different from the diopter of the central zone, and at least one of the central zone and the annular zone being aspherical. The contact lens product of claim 47, wherein the annular zone is a first annular zone, the central zone has a diopter of PowC, and the maximum refractive power of the first annular zone is PowP1, which satisfies the following conditions :|PowC-PowP1| 3D.