TWI577391B - A method of producing danshen compound dropping pill and the danshen compound dropping pill thereof - Google Patents

Description

Compound Danshen Dripping Pills and preparation method of compound Danshen Dripping Pills

The invention relates to a method for preparing a compound Danshen dropping pill, in particular to a method for preparing a compound Danshen dropping pill with high forming rate, and the invention further comprises a compound salvia miltiorrhiza prepared by the method for producing the compound Danshen dripping pill. Drop pills.

The roots and stems of Salvia miltiorrhiza are one of the commonly used medicines in China. Salvia miltiorrhiza contains tanshinone, cryptotanshionone and isotanshionone, which have the effect of promoting blood circulation and removing blood stasis. Heart disease, chest tightness, palpitations and menstrual disorders. Salvia miltiorrhiza usually combines with Panax Pseudo-ginseny var notoginseng and Borneolum synthcticum to make compound Danshen. Compound Danshen can be made into different dosage forms. According to the patient's own medication habits, compound Danshen powder and compound can be used. Danshen liquid, compound Danshen tablets and compound Danshen dripping pills.

The conventional compound Danshen dripping pill is prepared by a method for preparing a compound Danshen dripping pill. The method for preparing the compound Danshen dripping pill comprises: mixing a medicinal material containing Danshen, Sanqi and borneol with molecular weight. Forming a mixture of 4000 g/mol polyethylene glycol and polyethylene glycol having a molecular weight of 6000 g/mol; indirectly heating the mixture in an oil bath at 85-90 ° C to form a to-be formed; and the to-be formed The object is dropped into a forming tank of an oil temperature of 6 ° C, and the object to be formed is subjected to cold forming to obtain the conventional compound Danshen dropping pills.

However, the heating of the mixture in the mixture is not easy to distinguish with a specific point. The amount of polyethylene glycol is uniformly mixed, so that the mixed medicine is easily deposited at the dripper, thereby causing the content of the active ingredients of the conventional compound Danshen dropping pills prepared in the same process to be different (for example, due to the process In the preceding paragraph, the content of the mixed medicinal material in the to-be-formed product is much higher than that in the back end of the process, so the conventional compound Danshen dropping pill obtained in the previous stage process has a higher effective component); and further, it is dropped into the forming tank. If the formed product is not cold-formed in time, it will often cause the synthetic particle size of the compound Danshen dripping pills to be uneven and the shape is not easy to control, which not only brings the visual perception of the people to the visual sense, but also reduces their desire to purchase. In addition, the content of the active ingredients of the conventional compound Danshen dripping pills is inconsistent, and it is impossible to quantify the dose to be taken, which causes people to suffer from medication.

In view of the above, it is necessary to provide a method for producing a compound Danshen dropping pill to solve the problem that the manufacturing method of the conventional compound Danshen dropping pill is difficult to uniformly shape the object to be formed, and the distribution of active ingredients therein is uneven.

The invention provides a method for manufacturing a compound Danshen dropping pill, which can improve the forming rate of the prepared compound Danshen dropping pill.

The invention provides a method for manufacturing a compound Danshen dripping pill, which is a compound Danshen dripping pill having a uniform active ingredient content.

The invention provides a compound Danshen dropping pill, which has a uniform particle size.

The present invention provides a method for preparing a compound Danshen dropping pill, comprising: preparing a Chinese herbal medicine powder comprising Salvia miltiorrhiza, Sanqi and borneol; mixing the Chinese herbal medicine powder, a first substrate and a second substrate to obtain a mixture, the Chinese herbal medicine powder, the weight ratio of the first substrate to the second substrate is 1.75:1:1, wherein the first substrate is a polyethylene glycol having a molecular weight of 1500 g/mol, and the second substrate is a molecular weight of 4000 g. /mol of polyethylene glycol; the mixture is placed in a container and indirectly heated through a first oil body to obtain a shape to be formed, the temperature of the first oil body is 75 ~ 80 ° C; The formed product is dropped into a second oil body via a dripper The temperature of the dripper is 70 to 80 ° C, and the temperature of the second oil body is 3 to 10 ° C.

The method for producing a compound Danshen dropping pill according to the present invention, wherein the Chinese herbal medicine powder comprises 74.26% of salvia miltiorrhiza, 24.38% of notoginseng and 1.36% of borneol.

The method for producing a compound Danshen dropping pill according to the present invention, wherein the salvia miltiorrhiza and the Panax notoginseng in the Chinese herbal medicine powder are each obtained by extracting, concentrating and granulating the raw materials.

A method for producing a compound Danshen dropping pill according to the present invention, wherein the temperature of the dripper is 75 °C.

The method for producing a compound Danshen dropping pill according to the present invention, wherein the dripper has a diameter of 1.5 to 3 mm.

A compound Danshen dropping pill is prepared by the above-mentioned compound Danshen dropping pill manufacturing method.

The method for preparing the compound Danshen dropping pill according to the present invention is that the Chinese herbal medicine powder and the substrate are mixed at a weight ratio of 1:1 to 1:2, wherein the weight ratio of the first substrate and the second substrate in the matrix is 1 :1~1:3, through the first substrate and the second substrate of a specific type and molecular weight, to facilitate subsequent formation of the compound Danshen dropping pills; and, in the first oil body and the second Under the specific temperature combination of the oil body, the compound to be formed can be condensed at an optimal rate to form the compound Danshen dropping pills, thereby improving the forming rate of the prepared compound Danshen dropping pills.

The method for manufacturing the compound Danshen dropping pill according to the present invention, wherein the Chinese herbal medicine powder and the matrix of the specific composition can be uniformly mixed at 75 to 80 ° C to obtain the object to be formed, so that the dripper is passed through the entire process. The sample to be formed into the shaped tower contains a uniform amount of Chinese herbal medicine powder to achieve the effect of obtaining a dose-fixed compound Danshen dropping pill.

The compound Danshen dropping pill according to the present invention is prepared by the method for preparing the compound Danshen dropping pill, wherein the temperature of the first oil body is 75-80 ° C, and the temperature of the second oil body is 3~ At 10 ° C, the temperature of the first oil body and the second oil body is matched to achieve the effect of having a uniform particle size of the compound Danshen dropping pills.

The compound Danshen dropping pill of the present invention is obtained by the manufacturing method of the compound Danshen dropping pill, and the substrate selection in the method, the temperature of the first oil body and the temperature of the second oil body can be controlled. The compound Danshen dropping pills have a rounded and full appearance, thereby achieving the effect of increasing the willingness of the consumer to purchase the compound Danshen dropping pills.

The above and other objects, features and advantages of the present invention will become more <RTIgt; The manufacturing method comprises: preparing a Chinese herbal medicine powder; uniformly mixing the Chinese herbal medicine powder with a substrate to obtain a mixture; heating the mixture to obtain a to-be-formed product; and dropping the to-be-formed product into a forming tower to Obtain a compound Danshen dripping pill.

In detail, the Chinese herbal medicine powder comprises salvia miltiorrhiza, notoginseng and borneol. The proportion of each component in the Chinese herbal medicine powder is not limited. In the present embodiment, the Chinese herbal medicine powder comprises 74.26% of salvia miltiorrhiza, 24.38 by weight. 3% of the icing and 1.36% of the borneol, the ratio of the Chinese herbal medicine powder can be better for the blood circulation. In addition, the Danshen and Sanqi series mentioned above can be obtained after the procedures of washing, drying and grinding of the raw materials of Salvia miltiorrhiza and Sanqi, or the Danshen and Sanqi mentioned above can also be used for Danshen and Sanqi. The raw materials are obtained by extracting, concentrating and granulating to obtain concentrated fine particles to increase the content of active ingredients in Danshen and Sanqi. Preferably, the Chinese herbal medicine powder has a water content of less than 5%, so that the Chinese herbal medicine powder can be better mixed with the matrix, and the Chinese herbal medicine powder can be reduced in water content by various drying means, and this embodiment is The Chinese herbal medicine powder was placed in an oven at 80 ° C for 12 hours.

The matrix comprises a first matrix and a second matrix, the first matrix is a polyethylene glycol (PEG) having a molecular weight of 1500 g/mol, and the second matrix is a molecule. A quantity of 4000 g/mol of polyethylene glycol, and the first substrate and the second matrix are mixed at a weight ratio of 1:1 to 1:3 to obtain the substrate, and the substrate is subsequently mixed with the Chinese herbal medicine powder and heated and melted. It has a suitable consistency to facilitate condensation forming of the object to be formed. Wherein, when the weight ratio of the Chinese herbal medicine powder, the first substrate to the second substrate is 1.75:1:1, and the subsequent heating can be mixed to form the object to be formed, the object to be formed has an appropriate consistency, so that the The shaped article has better formability.

The Chinese herbal medicine powder and the substrate are continuously mixed, and then the Chinese herbal medicine powder and the substrate are heated and stirred to be uniformly mixed, so that the Chinese herbal medicine powder and the substrate are not deteriorated due to temperature unevenness during heating and stirring, The indirect heating changes the matrix from a solid state to a molten state and is uniformly mixed with the herbal powder. More specifically, in this embodiment, the Chinese herbal medicine powder and the substrate are first placed in a container, the container is made of stainless steel, and the container is immersed in an oil bath, the oil bath is filled with a The first oil body, the heat is applied to the oil bath to enable the temperature of the first oil body to reach 75-80 ° C. During the heating process, a magnet rotor is added to the container at 500 rpm. The Chinese herbal medicine powder and the substrate are uniformly mixed at a rotation speed, and the first oil body has a large specific heat and can be uniformly heated during heating to avoid a sudden boiling, so as to uniformly transfer heat to the mixture and let the mixture The matrix is completely melted and uniformly mixed with the herbal powder to obtain a shaped object. The first oil body may be a food grade eucalyptus oil. In the present embodiment, the first oil body is a food grade eucalyptus oil supplied by Shin-Etsu Chemical Co., Ltd., and the viscosity value (viscosity at 25 ° C) at 25 ° C is The density was 102 mm ² /s, the specific gravity at 25 ° C was 0.996, and the refractive index at 25 ° C was 1.4029.

The sample to be formed is continuously dropped into a forming tower through a dripper, and the forming tower contains a second oil body having a temperature of 3 to 10 ° C, so that the object to be molded contacts the lower temperature of the forming tower. After the second oil body, it will be cold and condensed into a solid state by the molten state to obtain the compound Danshen dropping pills. The present invention does not limit the detailed configuration of the forming tower for accommodating the second oil body. In the example, the container is connected with a dropper, the dropper is connected to the inner space of the container, and the dripper is provided at one end of the dropper, and the shaped tower is disposed below the dripper, so that The shaped object may be attracted by gravity and dropped into the forming tower through the dripper; in addition, the forming tower is connected to a circulation device for extracting the second oil body from the bottom of the forming tower through the circulating device, and then Re-injecting the upper portion of the forming tower so that the second oil body can continuously circulate and generate a flow in the forming tower, so that the object to be formed passes through the flow of the second oil body in the forming tower to cause rolling. The shaped object is more easily formed in the second oil body, and is formed into a compound Danshen dropping pill having a rounded and full appearance. Wherein, when the temperature of the first oil body of the oil bath is 78 ° C, the temperature of the second oil body in the forming tower is preferably 6 ° C, and the temperature of the first oil body and the second oil body are matched. The second oil body may be a food grade eucalyptus oil. In this embodiment, the second oil body is the same as the first oil body. The object to be formed is cooled and formed in the forming tower for 30 to 40 seconds to obtain the compound Danshen dropping pills, but the present invention is not limited to the cooling forming time.

When the temperature of the first oil body is 75-80 ° C, the temperature of the dripper is maintained at 70-80 ° C, avoiding the drop tube when the object to be formed is separated from the container to the dripper. The cooling effect of the wall causes the shaped object to be condensed and formed before it reaches the forming tower. Preferably, the temperature of the dripper is 75 ° C to improve the forming effect of the object to be formed. In addition, the diameter of the dripper can be adjusted according to the desired amount of the compound Danshen dropping pill. For example, when the dripper has a diameter of 1.5 mm, a compound Danshen dropping pill having a weight of 27±2.7 mg can be obtained; When the diameter of the dripper is 2 mm, a compound Danshen dropping pill having a weight of 32±3.2 mg can be obtained; when the diameter of the dripper is 3 mm, a compound Danshen dropping pill having a weight of 50±5 mg can be obtained. The forming tower can be connected to a separation device through which the compound Danshen dropping pills are separated from the second oil body.

The compound Danshen dropping pill obtained by the preparation method of the compound Danshen dropping pill according to the present invention, wherein the substrate and the Chinese herbal medicine powder can be uniformly mixed at a temperature of 75 to 80 ° C to form the object to be formed. The formed compound Danshen dropping pills contain a uniform active ingredient. And the temperature of the first oil body and the second oil body are matched to increase the forming yield of the object to be formed, so that the compound Danshen dropping pills have a uniform size and a rounded appearance.

In summary, the method for manufacturing the compound Danshen dropping pill according to the present invention is to mix the Chinese herbal medicine powder with the matrix at a weight ratio of 1:1 to 1:2, wherein the first substrate and the second in the matrix The weight ratio of the matrix is 1:1~1:3, and the first substrate and the second substrate of a specific type and molecular weight are passed through, so that the mixture can be smoothly converted to form a thick concentration after receiving a heat energy. And assisting the formation of the compound Danshen dropping pills in the subsequent formation, and the object to be formed is optimally obtained under the specific temperature combination of the first oil body of the oil bath and the second oil body of the forming tower. The rate is condensed to form the compound Danshen dropping pills, thereby achieving the effect of increasing the forming rate of the prepared compound Danshen dropping pills.

Moreover, in the method for producing the compound Danshen dropping pill according to the present invention, the Chinese herbal medicine powder and the matrix of the specific composition can be uniformly mixed at 75 to 80 ° C to obtain the object to be formed, so that the whole process can be passed through the process. The sample to be formed into the second oil body by the dripper contains a uniform content of the Chinese herbal medicine powder, so that the compound Danshen dropping pills with uniform content of the active ingredient can be prepared by the method of the invention, so as to obtain the dose immobilization. The effect of compound Danshen Dripping Pills.

In addition, the compound Danshen dropping pills of the present invention are prepared by the method for producing the compound Danshen dropping pills, wherein the temperature of the first oil body is 75 to 80 ° C, and the second oil body temperature of the forming tower The temperature is 3~10 ° C, and the temperature of the liquid in the oil bath and the forming tower is matched to achieve the uniform particle size of the compound Danshen dropping pills.

Furthermore, the compound Danshen dropping pills of the present invention are obtained by the method for producing the compound Danshen dropping pills, and the matrix selection, the first oil body temperature and the second oil body temperature control in the method are The compound Danshen dropping pills can have a rounded and full appearance, thereby achieving the effect of increasing the willingness of the consumer to purchase the compound Danshen dropping pills.

Although the present invention has been disclosed by the above-described preferred embodiments, it is not intended to limit the invention, and it is apparent to those skilled in the art without departing from the spirit and scope of the invention. The various modifications and variations of the embodiments are still within the technical scope of the invention. The scope of the invention is defined by the scope of the appended claims.

Claims (6)

A method for preparing a compound Danshen dropping pill comprises: preparing a Chinese herbal medicine powder comprising Salvia miltiorrhiza, Sanqi and borneol; mixing the Chinese herbal medicine powder, a first substrate and a second substrate to obtain a mixture, The weight ratio of the first herbal matrix to the second matrix is 1.75:1:1, wherein the first matrix is a polyethylene glycol having a molecular weight of 1500 g/mol, and the second matrix is a molecular weight of 4000 g/mol. Ethylene glycol; the mixture is placed in a container and indirectly heated through a first oil body to obtain a material to be formed, the temperature of the first oil body is 75 to 80 ° C; and the sample to be formed is passed through a drop The head is dropped into a second oil body having a temperature of 70 to 80 ° C and a temperature of the second oil body of 3 to 10 ° C. The method for producing a compound Danshen dropping pill according to the first aspect of the invention, wherein the Chinese herbal medicine powder comprises 74.26% of salvia miltiorrhiza, 24.38% of notoginseng and 1.36% of borneol. The method for producing a compound Danshen dripping pill according to the second aspect of the invention, wherein the salvia miltiorrhiza and the panax notoginseng in the Chinese herbal medicine powder are each obtained by extracting, concentrating and granulating the raw materials. The method for producing a compound Danshen dropping pill according to the first aspect of the invention, wherein the temperature of the dripper is 75 °C. The method for producing a compound Danshen dropping pill according to the first aspect of the invention, wherein the dripper has a diameter of 1.5 to 3 mm. A compound Danshen dropping pill is prepared by the method for producing a compound Danshen dropping pill according to any one of claims 1 to 5.