TWI566783B - Mouthwash comprising silver polyacrylate - Google Patents

Description

Silver polymer mouthwash

The present invention relates to a mouthwash containing a silver polymer, which contains a water-soluble antibacterial acrylic polymer silver salt. The present invention utilizes the characteristics of a water-soluble polymer plus the antibacterial ability of silver ions to develop an effective, Quick and safe mouthwash.

Oral health has a great impact on human life. How to maintain oral cleansing is a basic common sense in our daily life. The most common way to maintain oral cleansing is to rinse your mouth and brush your teeth. Generally, brushing your teeth will be accompanied by toothpaste. The mouth can be rinsed with only water, of course, the effect is not very good, in order to effectively maintain oral cleaning, mouthwash is generally used to help clean the mouth.

The cleaning of the mouth is mainly caused by food residues and bacteria. The food residue can be removed by clearing the mouth, brushing teeth or flossing, but the bacteria in the mouth are not so easily removed. These bacteria will decompose in the mouth. The organic matter produces an unpleasant smell of sulfur, which is the origin of bad breath. The bacteria break down sugary foods (especially sucrose) in the plaque and ferment to produce acid. These acids (mainly lactic acid) are weak from the tooth structure. Place to invade, It dissolves the inorganic substances that damage the teeth and causes tooth decay. What is more serious is that the bacteria will be gingivitis and periodontal disease. Therefore, removing harmful bacteria in the oral cavity becomes an important target for daily oral cleaning.

Mouthwash is the best way to remove harmful bacteria from the mouth. With antibacterial ingredients added to the mouthwash, these antibacterial ingredients act to kill the bacteria during the mouthwash. The most commonly used antibacterial ingredients in mouthwash are chlorhexidine gluconate and cetylpyridinium chloride. Ingredients are relatively effective and relatively safe chemicals, but long-term use may still cause side effects such as broken oral mucosa, altered taste, dry mouth or burning irritations, and may also stain teeth to form spotted spots on the tooth surface. .

Some mouthwashes use alcohol as an antibacterial ingredient, except for sterilization. In addition, with some surfactants, mint or some flavoring ingredients can be added to the water in a micro-emulsified form, but the alcohol-containing mouthwash will be extremely irritating during the mouthwash, and it will also be bad for the oral mucosa. The impact of the development of a mouthwash can be safe, gentle, non-irritating and effective in removing bacteria from the mouth to prevent the occurrence of bad breath, tooth decay, gingivitis and periodontal disease.

Since ancient times, the bactericidal effect of silver has been well known and should be For the early time, humans used silver to make tableware, and found that silver tableware contained milk or food, which was less prone to spoilage. In the recent silver sterilization application, it expanded to the form of nano silver and silver ions.

The application of silver ions is mostly made of the inorganic salt of silver. With, for example, silver nitrate, silver acetate, and silver thiosulfate, the inorganic salts of silver are hardly soluble in water or slightly soluble in water, except for the above-mentioned silver salt.

In addition to the inorganic salts of silver, silver ions can also be small with organic Molecular compound or silver organic salt, the most famous is silver sulfadiazine, widely used in burn wound treatment and sterilization, but silver sulfadiazine is also insoluble in water.

Any of the above inorganic salts or organic compounds of silver are small Molecular antibacterial agents, so they all have the disadvantage of small molecule antibacterial agents, and are not suitable for use as an antibacterial ingredient in mouthwashes.

In order to achieve safe, gentle, non-irritating and effective removal of the oral cavity In order to prevent bad breath, tooth decay, gingivitis and periodontal disease, the present invention discloses the world's first mouthwash using water-soluble antibacterial acrylic polymer silver salt as an antibacterial ingredient.

The present invention relates to a mouthwash containing a silver polymer, which is a water-soluble antibacterial acrylic polymer silver salt.

The acrylic polymer in the water-soluble antibacterial acrylic polymer silver salt in the present invention may be polyacrylic acid, polymethacrylic acid, acrylic acid-maleic acid copolymer, methacrylic acid-maleic acid copolymer, acrylic acid. a sodium-sodium methacrylate copolymer, a copolymer of acrylic acid with other acrylic monomers or a copolymer of methacrylic acid with other acrylic monomers, the carboxylic acid group (-COOH) in these acrylic polymers An anion (-COO ^- ) of a water-soluble antibacterial acrylic polymer silver salt is provided.

In the water-soluble antibacterial acrylic polymer silver salt of the present invention The cation contains sodium and silver or potassium and silver. In order to make the acrylic polymer silver salt water-soluble, water-soluble antibacterial acrylic polymer silver salt -COOAg/(-COOAg+-COONa) or -COOAg/ The molar ratio of (-COOAg+-COOK) is preferably less than 0.66.

The content of silver in the mouthwash of the present invention is between 1 and 2000 ppm. Between, when the content of silver in the mouthwash is less than 1ppm, the silver content is too low, which may result in poor antibacterial effect, so that the bacteria in the mouth cannot be effectively removed during the mouthwash, but when the content of silver is more than 2000ppm, the mouthwash will There is an unbearable bitter taste, and the cost is too high, and consumers may not accept it.

In addition to the water-soluble antibacterial acrylic high score in the mouthwash of the present invention In addition to the silver salt, other ingredients can be added to increase the mouthfeel of the mouthwash. The most familiar of these ingredients is mint.

Preparation of water-soluble antibacterial acrylic polymer silver salt can be used a water-soluble antibacterial acrylic polymer sodium salt or a water-soluble antibacterial acrylic polymer potassium salt, which is subjected to metal ion exchange in water by using a sodium carboxylate group or a potassium carboxylate group and a silver salt to obtain a carboxylic acid. A water-soluble acrylic polymer of a silver (-COOAg) functional group, and then the sodium salt produced by metal ion exchange is removed by ultrafiltration to obtain a pure water-soluble antibacterial acrylic polymer silver salt. .

Experiment on the exchange ratio of water-soluble antibacterial acrylic polymer silver salt:

Pour 500cc of pure water into a 1 liter glass beaker, add 0.5g of sodium polycarboxylate (molecular weight >8,000,000) to the beaker, control the water temperature to 40 °C, stir it with magnetite, then 10% of 10g The silver nitrate aqueous solution was added to the beaker ten times. The interval between each addition was half an hour, the stirring was continued, the water temperature was controlled at 40 ° C, and the solution state was observed after each half hour of addition, and the results of the following table were obtained.

It can be seen from the table that the polyacrylic acid silver salt obtained when -COOAg/(-COOAg+-COONa) is more than 0.77 or more is insoluble in water, and at this time, the weight ratio of silver to polyacrylic acid silver salt is 52%, insurance Some, the ratio of -COOAg / (-COOAg + -COONa) is preferably less than 0.66 to obtain a water-soluble polyacrylic acid silver salt, or when the weight ratio of silver to polyacrylic acid silver salt is 47% or less, the polyacrylic acid silver salt is water-soluble. of.

Preparation of polyacrylic acid silver salt: 10 g of sodium polyacrylate (molecular weight > 8,000,000) was added to 2 liters of pure water at 40 ° C, and stirred at a high speed of 10,000 rpm for 3 minutes to obtain a very viscous transparent liquid, after which 10 g of 50% was obtained. The silver nitrate aqueous solution was divided into 5 times and added at a high speed of 10,000 rpm for 30 seconds. After the addition, Stirring was maintained for 5 minutes until the solution appeared clear and transparent, at which time the viscosity of the solution was greatly reduced to become a well-flowing clear aqueous solution.

Dilute the resulting solution to 10 liters, using a diameter of 3 inches A 12-inch spiral spiral ultrafiltration membrane module (screening molecular weight of 100,000), the diluted solution is concentrated to 1 liter, in the initial stage of the concentration process, 100cc of permeate is added, sodium chloride is added, It was found that white silver chloride was produced, and it was found that all the added silver nitrate had been ion-exchanged with the sodium carboxylate in the sodium polyacrylate to produce a silver carboxylate group, and the silver polyacrylate obtained by metal ion exchange was still It is left in the concentrate and is not filtered through the membrane.

Dilute the resulting 1 liter concentrate to 10 liters and concentrate Up to 1 liter, then diluted, and then concentrated to 1 liter, so that a relatively high purity aqueous solution of silver acrylate having a silver content of 6300 ppm can be obtained.

Preparation and use of mouthwash: The aqueous solution of silver polyacrylate containing 6300 ppm of silver prepared in the previous example was diluted with pure water to make a mouthwash with a silver content of 100 ppm. The mouthwash was completely irritating without any irritation and mild taste.

Antibacterial Test for Mouthwash: Test Standard - U.S. Pharmacopeia 35 NF 30 Micro-biological Tests (51) Antimicrobial Effectiveness Testing.

Test Method - The mouthwash and the bacterial solution were mixed in a volume ratio of 20 mL: 0.2 mL, and tested immediately after the contact time.

Test species - Escherichia coli, drug resistant Staphylococcus aureus (MRSA), Klebsiella pneumonia, Pseudomonas aeruginos.

The test results are shown below

Claims (4)

A silver-containing mouthwash containing a water-soluble antibacterial acrylic polymer silver salt, the functional group of the water-soluble antibacterial acrylic polymer silver salt molecule comprising silver carboxylate (-COOAg) and sodium carboxylate ( -COONa) either contains silver carboxylate and potassium carboxylate (-COOK), wherein the molar ratio of -COOAg/(-COOAg+-COONa) or -COOAg/(-COOAg+-COOK) is less than 0.66. The silver-containing mouthwash according to the first aspect of the patent application, wherein the water-soluble antibacterial acrylic polymer silver salt is a copolymer of silver acrylate and sodium acrylate, and the molar ratio of silver acrylate to sodium acrylate is lower than 66/34. According to the mouthwash of the first aspect of the patent application, the water-soluble antibacterial acrylic polymer silver salt is a copolymer of silver acrylate and sodium acrylate, and the molar ratio of silver acrylate to sodium acrylate is between 66/34 and 11/ Between 89. The silver-containing mouthwash according to item 1 of the scope of the patent application has a silver content of between 1 and 2000 ppm.