TWI537245B - Compounds for use in the treatment of autoimmune inflammatory disease - Google Patents

Compounds for use in the treatment of autoimmune inflammatory disease

Info

Publication number
TWI537245B
TWI537245B TW101126408A TW101126408A TWI537245B TW I537245 B TWI537245 B TW I537245B TW 101126408 A TW101126408 A TW 101126408A TW 101126408 A TW101126408 A TW 101126408A TW I537245 B TWI537245 B TW I537245B
Authority
TW
Taiwan
Prior art keywords
compounds
treatment
use
inflammatory disease
autoimmune inflammatory
Prior art date
Application number
TW101126408A
Other versions
TW201311636A (en
Inventor
Neil Frankish
Helen Sheridan
Original Assignee
Venantius Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201161510675P priority Critical
Priority to US201261651155P priority
Application filed by Venantius Ltd filed Critical Venantius Ltd
Publication of TW201311636A publication Critical patent/TW201311636A/en
Application granted granted Critical
Publication of TWI537245B publication Critical patent/TWI537245B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/19Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups having unsaturation outside the aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
TW101126408A 2011-07-22 2012-07-20 Compounds for use in the treatment of autoimmune inflammatory disease TWI537245B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US201161510675P true 2011-07-22 2011-07-22
US201261651155P true 2012-05-24 2012-05-24

Publications (2)

Publication Number Publication Date
TW201311636A TW201311636A (en) 2013-03-16
TWI537245B true TWI537245B (en) 2016-06-11

Family

ID=46584090

Family Applications (1)

Application Number Title Priority Date Filing Date
TW101126408A TWI537245B (en) 2011-07-22 2012-07-20 Compounds for use in the treatment of autoimmune inflammatory disease

Country Status (3)

Country Link
EP (1) EP2734497A1 (en)
TW (1) TWI537245B (en)
WO (1) WO2013014660A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103764608B (en) 2011-07-22 2016-02-03 贝南蒂乌斯有限公司 Indene derivatives for the treatment of inflammatory bowel disease
US20150141506A1 (en) * 2012-05-24 2015-05-21 Venantius Limited Indane dimers for use in the treatment of autoimmune inflammatory disease
CN106661061A (en) * 2015-07-22 2017-05-10 南京海融医药科技股份有限公司 Aryl propionic acid derivative composition and pharmaceutical purpose

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0865419B1 (en) * 1995-12-06 2003-08-06 Venantius Limited Indane dimer compounds and their pharmaceutical use

Also Published As

Publication number Publication date
EP2734497A1 (en) 2014-05-28
WO2013014660A1 (en) 2013-01-31
TW201311636A (en) 2013-03-16

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees