TWI514990B - Apparatus for non-invasive glucose monitoring - Google Patents

Description

Non-invasive glucose monitoring device

The present disclosure relates to a glucose monitoring device, and more particularly to a non-invasive glucose monitoring device.

Diabetes is a clinical syndrome caused by factors such as absolute or relative deficiency of insulin in the body, abnormal secretion time, impaired insulin action or resistance. If diabetes is not well controlled, it can cause acute complications such as hypoglycemia, ketoacidosis, and non-keto hyperosmolar coma. Serious long-term complications include cardiovascular disease, chronic renal failure, retinopathy, neuropathy, and microvascular disease.

For diabetics, it is important to monitor blood glucose from time to time. The primary goal of managing diabetes is to maintain normal blood sugar levels. If the patient can pay attention to the control of blood sugar on weekdays, it will effectively prevent the above complications.

At present, diabetes patients often use blood glucose machines for blood glucose monitoring. However, before using the blood glucose meter to measure the blood glucose concentration value, the blood sampling step must be performed. Fingertip blood collection is an invasive (destructive) sampling method, which is complicated and causes pain, which is also the most important factor affecting diabetes patients' ability to monitor blood glucose on their own.

Therefore, the non-invasive blood glucose detection method has become a major development trend of blood glucose detection. Current non-invasive glucose meters use a single method for measurement, such as acoustics, optics, and electricity. But they all measure blood sugar in human skin. However, the structure of the skin can be divided into epidermis, dermis, and subcutaneous tissue, and various tissues, blood vessels, and water in the skin generate a variety of scattered light and absorbed light, thereby affecting the measurement of the signal, thereby affecting the judgment of the blood sugar level.

The present disclosure provides a non-invasive glucose monitoring device that accurately measures blood glucose information.

The present disclosure provides a non-invasive glucose monitoring device comprising at least one light source, a first beam splitter, a photodetector set, a reference component, and a processing unit. The light source emits at least one light. The first beam splitter has a focusing function that causes light emitted by the light source to be incident by the first beam splitter and focused into the eyeball. The photodetector group measures the optical information and the absorbed energy information of the light reflected by the eyeball and transmitted to the photodetector group by the first beam splitter. The reference component receives the light from the first beam splitter, and the light reflected by the reference component is transmitted to the photodetector group by the first beam splitter, wherein the light emitted by the light source is transmitted to the light by the first beam splitter and the eyeball The detector group forms a first optical path, and the light emitted by the light source is transmitted to the photodetector group by the first beam splitter and the reference component to form a second optical path. The processing unit receives and processes the optical information and the absorbed energy information to obtain glucose information.

Based on the above, due to the non-invasive glucose monitoring device proposed by the present disclosure It has a reference component that eliminates changes in light intensity caused by environmental influences to obtain more accurate glucose information, thereby improving the accuracy of blood glucose information (eg, blood glucose levels) and also correcting the optomechanical system. In addition, when establishing the personal parameters of the user who has individual differences, the blood stasis can be analyzed without the needle in the future by the relationship with the reference component with the data of the first puncture.

The above and other objects and features of the present invention will become more apparent from the following description.

100, 300, 400, 500‧‧‧ non-invasive glucose monitoring devices

102, 142‧‧‧ light source

104, 130, 138, 146, 404‧‧ ‧ beamsplitter

106, 306, 406, 506, 606, 1206‧‧‧Photodetector group

108‧‧‧Processing unit

110, 110a, 100b, 110c, 110d, 110e, 110f, 110g, 110h, 110i, 110j, 144‧‧‧ rays

112, 312, 412, 416, 612, 616‧‧‧ optical rotation measuring device

112a‧‧‧Polarizer

112b‧‧‧Photosensitive element

113, 115‧‧ ‧ light barrier

113a, 115a‧‧ hole

114, 314, 414, 418, 614, 618‧‧‧ energy measuring devices

116‧‧‧Light Information Analysis Unit

118‧‧‧ warning device

124‧‧‧Connecting components

126‧‧‧ sheath

128‧‧‧Reference components

132, 134‧‧ ‧ shutter

136‧‧‧ eye positioning device

140‧‧‧ camera

148‧‧‧Lens system

150‧‧ Sight

200‧‧‧ eyeballs

202‧‧‧ front room

204‧‧‧After room fluid

404‧‧‧Distributor

408, 508, 1208‧‧‧ first photodetector

410, 510, 1210‧‧‧ second photodetector

600, 700, 800, 900, 1000, 1100, 1200‧‧‧ portable mobile devices

601‧‧‧ light exit

602‧‧‧ device body

604, 904, 1004, 1204, 1304‧‧‧ optical kit

608‧‧‧ lens group

614a, 614b, 614c, 614d‧‧‧ Sensing area

1006‧‧‧ lens

S90, S100, S102, S104, S106, S108, S110, S112, S114, S116, S202, S204, S206, S208, S210, S212, S214, S216, S218‧‧

FIG. 1A is a schematic diagram of a non-invasive glucose monitoring device according to a first embodiment of the present disclosure.

FIG. 1B is a schematic diagram of the optical rotation measuring device of FIG. 1A.

2 is a schematic diagram of a non-invasive glucose monitoring device according to a second embodiment of the present disclosure.

FIG. 3 is a schematic diagram of a non-invasive glucose monitoring device according to a third embodiment of the present disclosure.

FIG. 4 is a schematic diagram of a non-invasive glucose monitoring device according to a fourth embodiment of the present disclosure.

FIG. 5 is a flow chart showing a non-invasive glucose monitoring method according to a fifth embodiment of the present disclosure.

FIG. 6 is a schematic diagram of a portable mobile device with a non-invasive glucose monitoring function according to a sixth embodiment of the present disclosure.

FIG. 7 is a schematic diagram of a portable mobile device having a non-invasive glucose monitoring function according to a seventh embodiment of the present disclosure.

FIG. 8 is a schematic diagram of a portable mobile device having a non-invasive glucose monitoring function according to an eighth embodiment of the present disclosure.

FIG. 9 is a schematic diagram of a portable mobile device having a non-invasive glucose monitoring function according to a ninth embodiment of the present disclosure.

FIG. 10 is a schematic diagram of a portable mobile device having a non-invasive glucose monitoring function according to a tenth embodiment of the present disclosure.

FIG. 11 is a schematic diagram of a portable mobile device having a non-invasive glucose monitoring function according to an eleventh embodiment of the present disclosure.

FIG. 12 is a schematic diagram of a portable mobile device having a non-invasive glucose monitoring function according to a twelfth embodiment of the present disclosure.

FIG. 13 is a schematic diagram of a portable mobile device having a non-invasive glucose monitoring function according to a thirteenth embodiment of the present disclosure.

FIG. 14 is a schematic view showing a method for analyzing biochemical molecules according to a fourteenth embodiment of the present disclosure.

The purpose of the disclosure is to provide a non-invasive glucose monitoring device Measure the glucose information (eg, glucose value) of the measurement object, and the glucose information (glucose concentration) in the eyeball (eg, the anterior chamber fluid in the eyeball) has a corresponding relationship with the blood glucose information (blood glucose concentration). In this correspondence, blood glucose information (eg, blood glucose level) is read by detecting the glucose information (glucose concentration) in the eyeball (eg, anterior chamber fluid in the eyeball) by the non-invasive glucose monitoring device of the present disclosure.

Another object of the present disclosure is to provide a non-invasive glucose monitoring method that continuously and instantaneously obtains a blood glucose level of a measurement subject.

FIG. 1A is a schematic diagram of a non-invasive glucose monitoring device according to a first embodiment of the present disclosure. FIG. 1B is a schematic diagram of the optical rotation measuring device of FIG. 1A.

Referring to FIG. 1A, a non-invasive glucose monitoring device 100 includes a light source 102, a beam splitter 104, a photodetector group 106, and a processing unit 108. The non-invasive glucose monitoring device 100 detects, for example, glucose in the aqueous humor 204 of the anterior chamber 202 of the eyeball 200.

Light source 102 emits light 110. The light source 102 is, for example, a light source such as a light emitting diode (LED) or a laser diode. The wavelength of the light source 102 is, for example, a glucose absorbable wavelength, that is, a wavelength that can be absorbed by glucose in the eye 200, such as a wavelength in infrared light. The light 110 emitted by the light source 102 includes linearly polarized light, circularly polarized light, elliptically polarized light or partially polarized light. In addition, the light source 102 has, for example, a function of controlling the emission frequency of the light 110, which helps the light detector 106 group determine the light to be measured by the transmission frequency. In addition, the light source 102 has a function of controlling the intensity of the light 110, for example, to ensure that the light energy entering the eyeball 200 does not cause damage. In addition, the light source 102 has, for example, a function of controlling the length of the opening time of the light ray 110 and controlling the length of the closing time of the light ray 110. Or a combination thereof, on the one hand, provides the time for glucose detection, and on the other hand ensures that the light energy entering the eye 200 does not cause harm. In this embodiment, although the single light source 110 emits a single light 110 as an example, the disclosure is not limited thereto. In another embodiment, the type of the light source 102 and the type of the light ray 110 may be two or more.

The beam splitter 104 has a focusing function that causes the light 110 emitted by the light source 102 to be incident by the beam splitter 104 and focused into the eyeball 200. The beam splitter 104, for example, focuses the light 110 onto the anterior chamber 202 of the eye 200, and the light reflected by the light 110 through the eye 200 includes reflected light from the anterior chamber fluid 204. The beam splitter 104 is, for example, an optical film, a lens, a grating or a diffractive optical element or a combination of any of the above.

The photodetector group 106 measures the optical information and the absorbed energy information of the light 110 reflected by the eyeball 200 and transmitted to the photodetector group 106 by the beam splitter 104. In this embodiment, the photodetector set 106 includes an optical rotation measuring device 112 and an energy measuring device 114. The optical rotation measuring device 112 is configured to measure the optical rotation information of the light 110 reflected by the eyeball 200 and reflected by the beam splitter 104, and the energy measuring device 114 is configured to measure and reflect through the eyeball 200. Absorbed energy information of the light 110 of the beam splitter 104.

In another embodiment, the optical rotation measuring device 112 and the energy measuring device 114 can be interchanged, that is, the optical rotation information of the light 110 reflected by the eyeball 200 and then passed through the optical splitter 104 can be measured by the optical rotation measuring device 112. The energy measurement device 114 measures the absorbed energy information of the light 110 reflected by the eyeball 200 and reflected by the beam splitter 104.

Referring to FIG. 1B, the optical rotation measuring device 112 includes a polarizing plate 112a and a photosensitive element 112b, wherein the light passes through the polarizing plate 112a and then to the photosensitive element 112b. Spin The light measuring device 112 is, for example, an active optical rotation measuring device or a passive optical rotating measuring device, wherein the measuring angle of the active optical measuring device can be varied, and the measuring angle of the passive optical measuring device is fixed. The active optical rotation measuring device is, for example, an analyzer, and the analyzer can directly calculate the optical rotation information. The passive optical rotation angle measuring device calculates the optical rotation angle information by measuring the energy of the light 110 passing through the polarizing plate 112a by the photosensitive element 112b. The energy measuring device 114 is, for example, a photosensitive element such as a charge coupled device, a complementary metal oxide semiconductor sensor or a photodiode.

In addition, referring to FIG. 1A and FIG. 1B simultaneously, the non-invasive glucose monitoring device 100 further optionally includes at least one of a light blocking plate 113 and a light blocking plate 115. The light blocking plate 113 has a hole 113a and is assembled such that the light 110 first passes through the hole 113a of the light blocking plate 113 and is then transferred to the photosensitive member 112b. The light blocking plate 113 is disposed between the polarizing plate 112a and the photosensitive element 112b, for example, but is not intended to limit the disclosure. In another embodiment, the light barrier 113 can be further assembled such that the light 110 passes through the polarizer 112a and then through the aperture 113a of the light barrier 113. In addition, the light blocking plate 115 has a hole 115a and is assembled such that the light 110 passes through the hole 115a of the light blocking plate 115 and is then transmitted to the energy measuring device 114 (e.g., the photosensitive member). The light blocking plates 113, 115 are respectively, for example, metal reticle or quartz glass reticle. The light blocking plates 113 and 115 respectively prevent stray light from entering the optical rotation measuring device 112 and the energy measuring device 114, so that the interference of stray light can be reduced, thereby improving the signal/noise ratio (S/N ratio). It should be noted that in each of the following embodiments, the influence of the stray light on the measurement result of the optical rotation measuring device and the energy measuring device can be reduced by the light blocking plate. However, in another embodiment, in order to simplify the description, Omit the description of the light barrier.

Referring to FIG. 1A, the processing unit 108 is, for example, associated with the photodetector group 106. The optical rotation measuring device 112 and the energy measuring device 114 are coupled to receive and process the optical information and the absorbed energy information to obtain the light 110 emitted by the light source 102 and the light 110 transmitted to the photodetector group 106. The optical rotation changes and the absorption energy changes, and the changes of optical rotation and absorption energy are analyzed to obtain biochemical molecular information of biochemical molecules. The biochemical molecules include at least glucose, and the processing unit obtains glucose information through biochemical molecular information. The biochemical molecule is, for example, cholesterol, uric acid, water, lactic acid, urea, ascorbic acid or a combination thereof. In addition, interfering molecules may be included in the biochemical molecule, such as molecules other than the labeled (eg, glucose), such as cholesterol, uric acid, water, lactic acid, urea, or ascorbic acid. Among them, ascorbic acid and lactic acid may interfere with the optical information, and water may interfere with the absorption of energy information. In the process of obtaining glucose information by processing unit 108, processing unit 108 may exclude interference caused by interfering molecules. The processing unit 108 can also statistically analyze the optical rotation information and absorb the energy information from the control light source variation, the optical component spatial offset or a combination thereof to obtain glucose information, and the light source change includes a change of the light emission frequency, a change of the light energy intensity, and A change in the length of the light on time, a change in the length of the light off time, or a combination thereof. Since the glucose concentration in the eyeball (eg, the anterior chamber fluid in the eyeball) has a corresponding relationship with the blood glucose concentration, the eyeball is detected by the non-invasive glucose monitoring device disclosed in the present disclosure (eg, the anterior chamber fluid in the eyeball) Blood glucose information (eg, blood glucose level) is read from the glucose information (glucose concentration). The processing unit 108 is, for example, an analog digital circuit integration module, wherein the analog digital circuit integration module includes a microprocessor, an amplifier, and an analog digital converter. The analog digital circuit integration module can further include a wireless transmission device.

In this embodiment, the processing unit 108 is coupled to the light source 102, for example. To control the optical properties of the light 110 emitted by the source 102.

The non-invasive glucose monitoring device 100 further includes an optical information analyzing unit 116 for detecting light information of the light 110 from the beam splitter 104 before the light 110 is incident on the eyeball 200, and the light 110 can be Light information is selectively transmitted to processing unit 108 or alert 118 to provide feedback control of the optical characteristics of light 110. The optical information analysis unit 116 includes at least one of an optical power meter and a light sensor. The light information detected by the optical power meter is energy information, and the light information detected by the light sensor is energy information and location information. At least one of them. The optical properties of the light 110 are, for example, the energy of the exit and/or the position of the light.

When the emission energy of the light 110 emitted by the light source 102 is too high, the light 110 may cause damage to the eyeball 200. Therefore, when the processing unit 108 receives the energy information of the light 110 that is too high in energy emission, the processing unit 108 reduces the emission energy of the light 110 emitted by the light source 102. On the other hand, when the warning device 118 receives the energy information of the light 110 that is too high, the warning device 118 emits a warning signal such as light or sound to inform the light source of the light 110 emitted by the light source 102. High, the emission energy of the light 110 needs to be adjusted. Therefore, the optical information analyzing unit 116 can prevent the eyeball 200 from being damaged by the excessive energy of the light emitted from the light 110.

In addition, when the position of the light ray 110 emitted by the light source 102 is shifted, the accuracy of the glucose measurement is lowered. Therefore, when the processing unit 108 receives the position information of the light position of the light ray 110, the processing unit 108 adjusts the light position of the light ray 110 emitted by the light source 102. On the other hand, when the alerter 118 receives the position information of the light ray 110 that generates the offset, the alerter 118 emits light. Or a warning signal such as a sound to inform the messenger that the position of the light of the light 110 emitted by the light source 102 is shifted, and the position of the light of the light 110 needs to be adjusted. Therefore, the optical information analyzing unit 116 can prevent the shift of the light position of the light 110, thereby improving the accuracy of the glucose measurement.

In this embodiment, the energy information detected by the optical information analyzing unit 116 is simultaneously transmitted to the processing unit 108 and the alerter 118 as an example, but the energy information is transmitted to the processing unit 108 and the alerter 118. One of them can perform the feedback control operation. For example, the optical information analysis unit 116 is coupled to the processing unit 108 and the alarm 118, but the optical information analysis unit 116, the processing unit 108, and the alarm 118 are not limited thereto.

In another embodiment, the light source 102 is coupled to a light source control unit (not shown), for example, when the light information analysis unit 116 transmits the energy information of the light 110 to the light source control unit to perform feedback control on the light source 102. .

In addition, in this embodiment, the light information analysis unit 116 is used to detect the light 110 reflected by the beam splitter 104 before the light 110 is incident on the eyeball 200.

The non-invasive glucose monitoring device 100 more preferably includes a reference element 128. The reference element 128 receives the light 110 from the beam splitter 104, and the light 110 reflected by the reference element 128 is transmitted by the beam splitter 104 to the light detector set 106, wherein the light 110 emitted by the light source 102 is passed through the splitter 104 The eyeball 200 is transmitted to the photodetector group 106 to form a first optical path, and the 110 rays emitted by the light source 102 are transmitted to the photodetector group 106 by the beam splitter 104 and the reference component 128 to form a second optical path. With this, you can check The influence of the environment on the light 110, such as the temperature change inside and outside the system and the noise interference of the circuit itself, is affected by the absorption energy intensity and the optical rotation intensity to facilitate internal correction.

Reference element 128 can be a reference sheet or a reference solution. Reference element 128 is, for example, a light absorbing material, a reflective light material or a solution. For example, the reference element 128 is, for example, a vapor deposition sheet, a light absorbing sheet, or a glucose standard concentration solution or the like.

The light 110 reflected by the reference element 128 on the second optical path has a characteristic intensity. The photodetector set 106 obtains the reference intensity of the light 110 reflected by the reference element 128 from the second optical path when actually measuring. The processing unit 108 can obtain the optical change and the absorbed energy change between the light 110 emitted by the light source 102 and the light 110 transmitted to the photodetector set 106 from the first optical path, and by comparing the characteristic intensity with the reference intensity, The light intensity change caused by the environmental influence is excluded, and the biochemical molecular information of the biochemical molecule is obtained, the biochemical molecule includes at least glucose, and the processing unit 108 obtains the glucose information by the biochemical molecular information, and the glucose information has a corresponding relationship with the blood sugar information, The disclosed non-invasive glucose monitoring device detects glucose information (glucose concentration) in the eyeball (eg, anterior chamber fluid in the eyeball) and reads the blood glucose information. Since the intensity of the light (such as the change in absorbed energy intensity and the change in optical intensity) caused by environmental influences can be excluded by the characteristic intensity and reference intensity provided by reference element 128, internal correction can be performed to obtain more accurate glucose information. To improve the accuracy of blood glucose information (eg, blood glucose levels), and to calibrate the optomechanical system. In addition, when establishing the personal parameters of the user who has individual differences, the blood stasis can be analyzed without the needle in the future by the relationship with the reference element 128 with the data of the first puncture.

The non-invasive glucose monitoring device 100 more optionally includes a beam splitter 130. The beam splitter 130 transmits the light rays 110 from the beam splitter 104 to the reference element 128 and the light information analysis unit 116, respectively. In this embodiment, the light 110 reflected by the reference component 128 is transmitted to the optical splitter 104 by the optical splitter 130, and then transmitted to the photodetector set 106 by the optical splitter 104, but is not intended to limit the disclosure. Those of ordinary skill in the art can adjust the relative position of reference element 128 to beam splitter 130 as desired. In addition, in this embodiment, although the reference component 128 and the optical information analysis unit 116 are located on different sides of the beam splitter 130, it is not intended to limit the disclosure. In another embodiment, the reference component 128 and the optical information analysis unit 116 may also be located on the same side of the beam splitter 130. In addition, the position of the reference component 128 of FIG. 1A and the optical information analysis unit 116 can also be interchanged.

The non-invasive glucose monitoring device 100 more preferably includes at least one of a shutter 132 and a shutter 134. The shutter 132 is disposed on the first optical path between the beam splitter 104 and the eyeball 200. The shutter 134 is disposed on the second optical path between the beam splitter 104 and the reference element 128. The shutter 132 may be closed prior to measuring the eye 200. Until the light information analysis unit 116 determines that the emission energy of the light 110 emitted by the light source 102 does not cause damage to the eye 200, the shutter 132 is opened again. In addition, the shutter 134 may be opened before the photodetector set 106 obtains the reference intensity of the light 110 reflected by the reference element 128 from the second optical path. Until the photodetector group 106 obtains the above reference intensity, the shutter 134 is closed.

Based on the above, the reference component 128 can eliminate the change in light intensity caused by environmental influences (such as changes in absorbed energy intensity and changes in optical rotation intensity), so the non-invasive glucose monitoring device 100 can perform internal calibration to obtain more accurate glucose. Information Improve the accuracy of blood glucose information (eg, blood glucose levels).

The non-invasive glucose monitoring device 100 more optionally includes an eye positioning device 136. The eye positioning device 136 includes a beam splitter 138 and a camera 140.

The beam splitter 138 is disposed on the first optical path between the beam splitter 104 and the eyeball 200. The beam splitter 138 is, for example, a beam splitter that controls the penetration and reflection ratio according to the wavelength.

The camera 140 receives the image information transmitted by the beam splitter 138. Camera 140 can be coupled to processing unit 108. The camera 140 is, for example, a microcamera. When the camera 140 can receive the light 110 emitted by the light source 102, the image information can be the position where the light 110 is illuminated to the eye 200. From this image information, it can be determined whether the light 110 falls in the correct eye measurement position (eg, pupil). In addition, the camera 140 can also be used for user identity comparison, for example, the camera 140 can be used to identify the iris of the eye, thereby not only enhancing the security of the personal security, but also processing the data for the remote medical treatment and the remote care. For convenience.

Eye positioning device 136 more preferably includes a light source 142. The light source 142 emits light 144, which is incident on the eyeball 200 by the beam splitter 138, and the light 144 reflected by the eyeball 200 is transmitted to the camera 140 by the beam splitter 138. Light source 142 is, for example, a source of visible light or a source of invisible light. When the light source 142 is a visible light source, the light source 142 can also be used as a simple eye aiming positioning device for aligning the line of sight 150 of the eye with the positioning device for eye aiming to determine the position of the eye measurement. The light source 142 is, for example, a light emitting diode or a laser diode or an organic light emitting diode. In another embodiment, when the light source 142 is a source of invisible light, the non-invasive glucose monitoring device 100 can more optionally include other eye targeting devices, such as logos or embossed patterns.

The eye positioning device 136 more preferably includes a beam splitter 146. The light 144 emitted by the light source 142 is transmitted to the beam splitter 138 by the beam splitter 146, but is not intended to limit the disclosure. A person skilled in the art can select the light 144 emitted by the light source 142 to be transmitted to the beam splitter 138 according to requirements, as long as the light 144 emitted by the light source 142 can be transmitted to the beam splitter 138.

When the camera 140 can receive the light 144 emitted by the light source 142, the image information can be the position where the light 144 is illuminated to the eye 200. At this time, the light ray 110 transmitted to the eyeball 200 by the beam splitter 138 has an optical path correspondence relationship with the light ray 144, and the optical path correspondence relationship is, for example, a coaxial or a different axis. The relationship between the image information and the optical path at the position where the light ray 144 is incident on the eye 200 can obtain the position at which the light 110 is irradiated to the eye 200, so that it can be determined whether the light 110 falls at the correct eye measurement position (eg, pupil). The image information is, for example, a spot formation pattern.

For example, when the light ray 110 transmitted to the eyeball 200 by the beam splitter 138 is coaxial with the light ray 144, the position where the light ray 144 is irradiated to the eyeball 200 corresponds to the position where the light ray 110 is irradiated to the eyeball 200, so that the camera 140 is used by the camera 140. The received light 144 can be used to know the position at which the light 110 is incident on the eye 200, so that it can be determined whether the light 110 is at the correct eye measurement position (e.g., pupil).

In addition, when the light ray 110 transmitted to the eyeball 200 by the beam splitter 138 is different from the light ray 144, the relative optical path relationship between the light ray 110 transmitted to the eyeball 200 by the beam splitter 138 and the light ray 144 can be utilized. (e.g., angle), and the light 144 received by the camera 140 estimates the position at which the light 110 is incident on the eye 200, thereby determining whether the light 110 is at the correct eye measurement position (e.g., pupil).

In this embodiment, the light ray 110 transmitted to the eyeball 200 by the beam splitter 138 is coaxial with the light 144, but the disclosure is not limited thereto. Those having ordinary skill in the art can measure the light rays 110 transmitted to the eyeball 200 by the beam splitter 138 and the light rays 144 to be set to different axes with reference to the disclosure.

Glucose monitoring can be performed when it is determined that the light 110 is at the correct eye measurement position. In addition, when it is determined that the light 110 does not fall in the correct eye measurement position, an active alignment adjustment method or a passive alignment adjustment method may be employed.

The active alignment adjustment method can perform the alignment of the eyeball 200 by adjusting the relative position between the eyeball 200 and the light 100. For example, the user may be asked to adjust the position of the eyeball 200 or to adjust the beam focus position of the light 110. Additionally, eye positioning device 136 more selectively includes lens system 148. The lens system 148 is disposed on the first optical path between the light source 102 and the beam splitter 104, and can be used to dynamically adjust the beam focus position of the light 110 to align the eye measurement position so that the measurement signal is accurately and stably outputted. In addition, by the lens system 148, the focus can be scanned on the optical axis, that is, the scanning can be performed at different depths corresponding to the object to be tested (for example, the human eye), and the values of other regions can be actively measured. In addition, when it is determined that the light 110 does not fall in the correct eye measurement position, it may be set to not measure, record, or use information that does not fall on the correct eye measurement position until the light 110 falls correctly. Glucose monitoring is performed when the eye is measured.

The passive alignment adjustment method can obtain the correct glucose information through the operation processing of the back end by the deviation value between the position where the light 110 falls on the eyeball 200 and the correct eye measurement position.

In this embodiment, the light source 142 is exemplified by a visible light source, and The line of sight of the eye is aligned with the light source 142 for alignment and measurement, but the disclosure is not limited thereto. In another embodiment, regardless of whether the light source 142 is a visible light source or an invisible light source, the line of sight of the eye can also be aligned and measured without misaligning the light source 142.

Based on the above, the eye positioning device 136 can avoid the measurement error caused by the light 110 not falling on the correct eye measurement position, thereby enabling the non-invasive glucose monitoring device 100 to obtain more accurate glucose information, thereby improving The accuracy of blood glucose information (eg, blood glucose values).

The non-invasive glucose monitoring device 100 more preferably includes a connecting element 124. One end of the connecting member 124 is connected to the light exit of the non-invasive glucose monitoring device 100, and the other end of the connecting member 124 is used to abut against the outer edge of the eye. In addition, the non-invasive glucose monitoring device 100 can further include a sheath 126 disposed on the side of the connecting member 124 for abutting against the outer edge of the eye. The sheath 126 is, for example, a disposable sheath.

Based on the first embodiment, in the non-invasive glucose monitoring device 100, the optical rotation change and the absorption energy change between the light 110 emitted by the light source 102 and the light 110 transmitted to the photodetector group 106 can be simultaneously changed. Performing an analysis to measure glucose information (eg, glucose value), because the glucose concentration in the eyeball (eg, the anterior chamber fluid in the eyeball) has a corresponding relationship with the blood glucose concentration, and through this correspondence, the non-invasive type disclosed by the present disclosure The glucose monitoring device detects glucose information (glucose concentration) in the eyeball (eg, anterior chamber fluid in the eyeball) and reads blood glucose information (eg, blood glucose level) with high accuracy.

In addition, the non-invasive glucose monitoring device 100 can be used for miniaturization, for example, in a headband type or in combination with glasses, thereby improving the convenience of use. In addition, the use environment of the non-invasive glucose monitoring device 100 is not particularly limited and can be indoors or Outdoor use.

2 is a schematic diagram of a non-invasive glucose monitoring device according to a second embodiment of the present disclosure.

Referring to FIG. 1A and FIG. 2 of the present invention, the non-invasive glucose monitoring device 300 of the second embodiment is different from the non-invasive glucose monitoring device 100 of the first embodiment in the photodetector group of the second embodiment. The optical rotation measuring device 312 and the energy measuring device 314 in the 306 are located on the same side of the optical splitter 104, and the optical rotation measuring device 112 and the energy measuring device 114 in the photodetector group 106 of the first embodiment are respectively located in the optical splitting. Both sides of the device 104. The optical rotation measuring device 312 and the energy measuring device 314 are respectively coupled to the processing unit 108, respectively, but are not intended to limit the disclosure. The components, connection relationships, and functions of the other components of the non-invasive glucose monitoring device 300 of the second embodiment are similar to those of the non-invasive glucose monitoring device 100 of the first embodiment, and thus will not be described herein.

In this embodiment, the photodetector set 306 is used, for example, to measure the light 110 reflected by the eyeball 200 and reflected by the beam splitter 104. The light 110 to be measured is, for example, first transmitted to the optical rotation measuring device 312 for measurement of the optical rotation information, and then entered into the energy measuring device 314 for measurement of the absorbed energy information. In another embodiment, the photodetector set 306 can also be used to measure the light 110 reflected by the eyeball 200 and then passed through the beam splitter 104.

In another embodiment, the non-invasive glucose monitoring device 300 further includes another set of optical rotation measuring device 312 and energy measuring device 314, and has two sets of optical rotation measuring device 312 and energy measuring device 314 at the same time, The optical information and the absorbed energy information of the light 110 reflected by the eyeball 200 and then passed through the beam splitter 104 are respectively measured and measured by The optical information and energy absorption information of the light 110 reflected by the eyeball 200 and reflected by the beam splitter 104.

Similarly, since the non-invasive glucose monitoring device 300 of the second embodiment can simultaneously analyze the optical change and the absorbed energy change between the light 110 emitted by the light source 102 and the light 110 transmitted to the photodetector group 306. And the glucose information (eg, glucose value) is measured, and since the glucose concentration in the eyeball (eg, the anterior chamber fluid in the eyeball) has a corresponding relationship with the blood glucose concentration, the non-invasive glucose monitoring by the present disclosure is transmitted through the correspondence relationship. The device detects glucose information (glucose concentration) in the eyeball (eg, anterior chamber fluid in the eyeball) and reads blood glucose information (eg, blood glucose level) with high accuracy. In addition, the non-invasive glucose monitoring device 300 can be miniaturized, so it is quite convenient to use and can be used indoors or outdoors.

FIG. 3 is a schematic diagram of a non-invasive glucose monitoring device according to a third embodiment of the present disclosure.

Referring to FIG. 1A and FIG. 3 of the present invention, the non-invasive glucose monitoring device 400 of the third embodiment is different from the non-invasive glucose monitoring device 100 of the first embodiment in the non-invasive glucose monitoring of the third embodiment. The device 400 further includes a beam splitter 404, and the photodetector group 406 includes a first photodetector 408 and a second photodetector 410. The constituent devices, connection relationships, and functions of the other components of the non-invasive glucose monitoring device 400 of the third embodiment are similar to those of the non-invasive glucose monitoring device 100 of the first embodiment, and thus will not be described herein.

The beam splitter 404 transmits the light 110 reflected by the eyeball 200 and transmitted by the beam splitter 104 to the photodetector set 406. The beam splitter 404 is, for example, an optical film, which is transparent. Mirror, grating or diffractive optical element or a combination of any of the above.

The first photodetector 408 is used to measure the light 110 reflected by the beam splitter 404, and the second photodetector 410 is used to measure the light 110 passing through the beam splitter 404. The first photodetector 408 includes an optical rotation measuring device 412 and an energy measuring device 414 , and the second optical detector 410 includes an optical rotation measuring device 416 and an energy measuring device 418 . The light 110 to be measured is, for example, first transmitted to the optical rotation measuring device 412 (or 416) for measurement of the optical rotation information, and then entered into the energy measuring device 414 (or 418) for measurement of the absorbed energy information. The components of the optical rotation measuring devices 412, 416 are similar to those of the optical rotation measuring device 112 of the first embodiment, and the components of the energy measuring devices 414, 418 and the energy measuring device 114 of the first embodiment. The composition of the device is similar, so it will not be described here. When the first photodetector 408 and the second photodetector 410 in the non-invasive glucose monitoring device 400 can simultaneously measure the optical information and the absorbed energy information, the two groups obtained by simultaneous cross-alignment can be obtained. The optical information and the absorbed energy information are analyzed, and the optical change and the absorbed energy change between the light 110 emitted by the light source 102 and the light 110 transmitted to the photodetector group 406 are analyzed, and glucose information (eg, glucose is measured). Value), because the glucose concentration in the eyeball (eg, the anterior chamber fluid in the eyeball) has a corresponding relationship with the blood glucose concentration, and through this correspondence, the non-invasive glucose monitoring device of the present disclosure detects the eyeball (eg, in the eyeball) Glucose information (glucose concentration) in the anterior chamber fluid) is used to read blood glucose information (eg, blood glucose level) with high accuracy. The optical rotation measuring devices 412, 416 and the energy measuring devices 414, 418 are respectively coupled to the processing unit 108, respectively, but are not intended to limit the disclosure.

It should be noted that when the optical rotation measuring devices 412, 416 are both passive optical rotation measuring devices and each includes a polarizing plate, the polarizing plates in the optical rotation measuring devices 412, 416, for example, It is one of the horizontal polarizer and the vertical polarizer and the other, or a polarizer of two known angles. If two sets of polarizing plates with known optical rotation angles are combined, one of the measurement methods is to compare the energy difference between the two groups. The difference in energy can be seen that the optical rotation change is in a specific glucose concentration range to improve the detection accuracy. Another method is to determine the offset component by the absorption energy change by using two sets of polarizing plates with known optical rotation angles, and then calculate the optical rotation information.

In another embodiment, one of the first photodetector 408 and the second photodetector 410 is, for example, a single optical measuring device, the first photodetector 408 and the second photodetector 410. The other of them is, for example, a single energy measuring device.

In addition, in the above embodiment, although the light 110 reflected by the beam splitter 404 and/or the light 110 passing through the beam splitter 404 is exemplified by a light. However, the light 110 reflected by the beam splitter 404 and/or the light 110 passing through the beam splitter 404 can be split into two or more light beams by the beam splitter 404, and then by the first photodetector 408 described above and The second photodetector 410 performs the measurement.

Based on the third embodiment, the non-invasive glucose monitoring device 400 can simultaneously analyze the optical change and the absorbed energy change between the light 110 emitted by the light source 102 and the light 110 transmitted to the photodetector group 406. The glucose information (eg, glucose value) is measured, and since the glucose concentration in the eyeball (eg, the anterior chamber fluid in the eyeball) has a corresponding relationship with the blood glucose concentration, the non-invasive glucose monitoring device of the present disclosure is detected by the corresponding relationship. Blood glucose information (eg, blood glucose level) with high accuracy is read by measuring glucose information (glucose concentration) in the eyeball (eg, anterior chamber fluid in the eyeball). In addition, the non-invasive glucose monitoring device 400 can be miniaturized, so it is quite convenient to use and can be indoors or Outdoor use.

FIG. 4 is a schematic diagram of a non-invasive glucose monitoring device according to a fourth embodiment of the present disclosure.

Referring to FIG. 3 and FIG. 4 of the present invention, the non-invasive glucose monitoring device 500 of the fourth embodiment is different from the non-invasive glucose monitoring device 400 of the third embodiment in the non-invasive glucose of the fourth embodiment. In the monitoring device 500, the photodetector group 506 includes a first photodetector 508 and a second photodetector 510, and the first photodetector 508 and the second photodetector 510 are located in the same optical splitter 404. side. In this embodiment, the first photodetector 508 and the second photodetector 510 are, for example, located on a side of the light ray 110 that passes through the optical splitter 404, and are respectively used to measure the light ray 110 passing through the optical splitter 404. Light rays 110a, 100b. One of the first photodetector 508 and the second photodetector 510 is, for example, an optical rotation measuring device for measuring optical rotation information, and the first photodetector 508 and the second photodetector 510 are used. The other of them is, for example, an energy measuring device for measuring energy absorption information. The first photodetector 508 and the second photodetector 510 are coupled to the processing unit 108, for example, but are not intended to limit the disclosure. The constituent devices, connection relationships, and functions of the other components of the non-invasive glucose monitoring device 500 of the fourth embodiment are similar to those of the non-invasive glucose monitoring device 400 of the third embodiment, and thus will not be described herein.

In another embodiment, the first photodetector 508 and the second photodetector 510 are also located on a side of the beam splitter 404 that reflects the light 110, and are respectively used to measure the light 110 reflected by the beam splitter 404. Two rays of light produced.

In the above embodiment, the light 110 reflected by the beam splitter 404 and/or the light 110 passing through the beam splitter 404 are exemplified by two light rays 110a and 100b. However, the light 110 reflected by the beam splitter 404 and/or the light 110 passing through the beam splitter 404 can be further divided into three or more light beams by the beam splitter 404, and then by the first light detector 508 described above. And the second photodetector 510 performs measurement.

Similarly, since the non-invasive glucose monitoring device 500 of the fourth embodiment can simultaneously change the optical rotation and the absorbed energy between the light 110 emitted by the light source 102 and the light 110a, 100b transmitted to the photodetector group 506. Performing an analysis to measure glucose information (eg, glucose value), because the glucose concentration in the eyeball (eg, the anterior chamber fluid in the eyeball) has a corresponding relationship with the blood glucose concentration, and through this correspondence, the non-invasive type disclosed by the present disclosure The glucose monitoring device detects glucose information (glucose concentration) in the eyeball (eg, anterior chamber fluid in the eyeball) and reads blood glucose information (eg, blood glucose level) with high accuracy. In addition, the non-invasive glucose monitoring device 500 can be miniaturized, so it is quite convenient to use and can be used indoors or outdoors.

FIG. 5 is a flow chart showing a non-invasive glucose monitoring method according to a fifth embodiment of the present disclosure.

Referring to FIG. 5, step S90 may be selectively performed to aim the eyeball at the eye aiming positioning device (eg, the light source 142) for aligning the line of sight of the eye with the positioning device for eye aiming, and the alignment includes The relative angle and position of the optical axis of the device and the line of sight of the eye are adjusted to determine the position of the eye measurement. In addition, the positioning of the eye may be performed in addition to the eye-targeting positioning device of the step S90, and in another embodiment, the eye-alignment mode as in step S108 may be employed. In addition, the eye alignment mode of step S90 and step S108 can also be employed at the same time.

Go to step S100 to emit at least one light from at least one light source.

Step S102 can be selectively performed to control the optical characteristics of the light source, the spatial offset of the optomechanical component, or a combination thereof, which can be used to generate a change factor, which helps to analyze more accurate glucose information. Wherein, the light source can control the emission frequency, intensity, opening time length, closing time length or a combination thereof. The photodetector group can determine the light to be measured by the transmission frequency. In addition, by controlling the intensity of the light source by the light source, it is ensured that the light energy entering the eyeball does not cause damage. In addition, by controlling the length of the light, the length of the closing time, or a combination thereof, the light source can provide the time for glucose detection, and on the other hand, ensure that the light energy entering the eyeball does not cause damage.

Step S104 may be selectively performed to detect light information of the light from the first beam splitter (eg, the beam splitter 104) before the light is incident on the eyeball to perform feedback control on the optical characteristics of the light. The light information includes at least one of energy information and location information. Optical properties are, for example, emission energy and/or light position.

Step S106 can be selectively performed to eliminate the change in light intensity caused by the environmental influence by the reference component. Thereby, the change in light intensity caused by environmental influences can be excluded. In addition, there is no certain order in the execution of step S104 and step S106.

Step S108 can optionally be performed to align the eye with an eye positioning device (e.g., eye positioning device 136). Thereby, the measurement error caused by the light not falling on the correct eye measurement position can be avoided.

Step S110 is performed to make the light emitted by the light source incident and focus into the eyeball by the first beam splitter having the focusing function (for example, the beam splitter 104).

One of step S112 and step S114 may be performed. Step S112 is to transmit the light reflected by the eyeball by the first beam splitter (eg, the beam splitter 104). Go to the light detector group. Step S114 is to transmit the light reflected by the eyeball to the second beam splitter (eg, the beam splitter 404) by the first beam splitter (eg, the beam splitter 104), and then by the second beam splitter (eg, the beam splitter 404). Transfer to the photodetector group.

Step S116 is performed to measure the optical information and the absorbed energy information of the light transmitted to the photodetector group by the photodetector group.

Step S118 is performed to obtain an optical rotation change and an absorption energy change between the light emitted by the light source and the light transmitted to the photodetector group by processing the optical rotation information and the absorption energy information.

Step S120 is performed to analyze the change of the optical rotation and the change of the absorbed energy to obtain biochemical molecular information of the biochemical molecule, the biochemical molecule includes at least glucose, and the glucose information is obtained by biochemical molecular information. In addition, since the glucose concentration in the eyeball (eg, the anterior chamber fluid in the eyeball) has a corresponding relationship with the blood glucose concentration, the non-invasive glucose monitoring device of the present disclosure detects the eyeball through the corresponding relationship (eg, the front of the eyeball) Blood glucose information (eg, blood glucose level) is read from the glucose information (glucose concentration) in the aqueous solution. Biochemical molecules such as cholesterol, uric acid, water, lactic acid, urea, ascorbic acid or a combination thereof. In addition, interfering molecules may be included in the biochemical molecule, such as molecules other than the labeled (eg, glucose), such as cholesterol, uric acid, water, lactic acid, urea, or ascorbic acid. Among them, ascorbic acid and lactic acid may interfere with the optical information, and water may interfere with the absorption of energy information. Will interfere with the absorption of energy information. In addition, in step S120, interference caused by interfering molecules is more selectively excluded. In another aspect, in step S120, the intensity of the light caused by the environmental influence is more selectively excluded by the characteristic intensity and the reference intensity provided by the reference component, so that internal correction can be performed to obtain more Accurate glucose information to improve the accuracy of blood glucose information (eg, blood glucose levels).

Various aspects and various use devices of the various non-invasive glucose monitoring methods of the fifth embodiment have been described in detail in the first to fourth embodiments, and thus will not be described again.

Based on the above, the non-invasive glucose monitoring method proposed in the fifth embodiment is capable of measuring the glucose information (eg, glucose value) of the measurement object by means of optically detecting the eyeball, and thus can be obtained continuously and instantaneously. Measuring glucose information (eg, glucose concentration) of the subject, and correlating the glucose concentration with the blood glucose concentration, and detecting glucose in the eyeball (eg, anterior chamber fluid in the eyeball) by the non-invasive glucose monitoring device disclosed herein Information (glucose concentration) can read blood glucose information (eg, blood glucose levels).

On the other hand, the non-invasive glucose monitoring device and method of the above embodiments are more applicable to the portable mobile device, and the portable mobile device has a non-invasive glucose monitoring function. Portable mobile devices are, for example, mobile phones, tablet computers, and digital cameras. Hereinafter, a portable mobile device having a non-invasive glucose monitoring function will be described by way of example.

FIG. 6 is a schematic diagram of a portable mobile device with a non-invasive glucose monitoring function according to a sixth embodiment of the present disclosure.

Referring to FIG. 2 and FIG. 6 simultaneously, the portable mobile device 600 of the sixth embodiment is different from the non-invasive glucose monitoring device 300 of the second embodiment in that the portable mobile device 600 further includes the device body 602 and the optical device. Kit 604. The optical package 604 is mounted on the device body 602, and the optical package 604 includes a beam splitter 104. The photodetector group 606, the processing unit 108, the light source 102, the optical information analyzing unit 116, and the alerter 118 are disposed in the body 602, for example, but are not intended to limit the disclosure. In addition, the photodetector group 606 includes an optical rotation measuring device 612 and an energy measuring device 614, wherein the portable mobile device 600 utilizes a photosensitive element in its camera module as the energy measuring device 614 in the photodetector group 606. The optical rotation measuring device 612 and the energy measuring device 614 are respectively coupled to the processing unit 108, but are not intended to limit the disclosure. The optical rotation measuring device 612 is, for example, an active optical rotation measuring device or a passive optical rotation measuring device. The energy measuring device 614 is, for example, a photosensitive element such as a charge coupled device, a complementary metal oxide semiconductor sensor, or a photodiode. In addition, the light 110 for performing glucose monitoring by the portable mobile device 600 is transmitted by using a light travel route in the camera module of the portable mobile device 600. The constituent devices, connection relationships, and functions of the other components of the portable mobile device 600 of the sixth embodiment are similar to those of the non-invasive glucose monitoring device 300 of the second embodiment, and in the sixth embodiment and the second embodiment Similar components are similar constituent devices, and the monitoring method of glucose can refer to the second embodiment, and thus will not be described herein. In addition, in order to simplify the drawing, the coupling relationship between the camera 140 and the processing unit 108 is not illustrated in FIGS. 6 to 13 .

In addition, in the sixth embodiment, one end of the connecting element 124 connecting element is connected to the light exit port 601 of the portable mobile device 600, and the other end of the connecting element 124 is used to abut the outer edge of the eye.

In another aspect, optical kit 604 can more optionally include lens set 608. When the optical kit 604 has the lens set 608, the optical kit 604 can be integrated into the lens in the camera module of the portable mobile device 600. Moreover, regardless of whether the optical kit 604 has the lens set 608, the lens in the camera module of the portable mobile device 600 can be replaced with an optical kit 604 for glucose monitoring. In another embodiment, the optical kit 604 can be directly attached to the portable action when the glucose monitoring is performed. On the lens in the camera module of device 600.

In this embodiment, light 110 emitted by light source 102 is incident by beam splitter 104 and focused into eye 200. The photodetector set 606 is, for example, used to measure the light 110 reflected by the eyeball 200 and passed through the beam splitter 104. The light 110 to be measured is, for example, first transmitted to the optical rotation measuring device 612 for measurement of the optical rotation information, and then entered into the energy measuring device 614 for measurement of the absorbed energy information.

Based on the above, the portable mobile device 600 of the sixth embodiment can simultaneously analyze the optical change and the absorbed energy change between the light 110 emitted by the light source 102 and the light 110 transmitted to the photodetector group 606. The glucose information (eg, glucose value) is measured, and since the glucose concentration in the eyeball (eg, the anterior chamber fluid in the eyeball) has a corresponding relationship with the blood glucose concentration, the non-invasive glucose monitoring device disclosed by the present disclosure is transmitted through the corresponding relationship. The glucose information (glucose concentration) in the eyeball (eg, anterior chamber fluid in the eyeball) is detected to read high-accuracy blood glucose information (eg, blood glucose level). In addition, since the glucose monitoring function is integrated into the portable mobile device 600, it is quite convenient in use. In addition, the mobile device 600 can be connected to the cloud using a program or network of the portable mobile device 600 to provide remote medical care.

FIG. 7 is a schematic diagram of a portable mobile device having a non-invasive glucose monitoring function according to a seventh embodiment of the present disclosure.

Referring to FIG. 6 and FIG. 7 simultaneously, the portable mobile device 700 of the seventh embodiment is different from the portable mobile device 600 of the sixth embodiment in that the portable mobile device 700 of the seventh embodiment further includes splitting. The device 404 (refer to the third embodiment), and the photodetector group 606 further includes an optical rotation measuring device 616 and an energy measuring device 618. Optical rotation measuring device 616 For example, an active optical rotation measuring device or a passive optical rotation measuring device. The energy measuring device 618 is, for example, a photosensitive element such as a charge coupled device, a complementary metal oxide semiconductor sensor, or a photodiode. The components, connection relationships, and functions of the other components of the portable mobile device 700 of the seventh embodiment are similar to those of the portable mobile device 600 of the sixth embodiment, and the seventh embodiment is similar to the sixth embodiment. The components are similar constituent devices, and the monitoring method of glucose can refer to the third embodiment, and thus will not be described herein.

The beam splitter 404 transmits, for example, the light 110 reflected by the eyeball 200 and transmitted by the beam splitter 104 to the photodetector set 606. The beam splitter 404 is, for example, an optical film, a lens, a grating or a diffractive optical element or a combination of any of the above.

In the photodetector group 606, the optical rotation measuring device 612 and the energy measuring device 614 are used, for example, to measure the light 110c reflected by the eyeball 200 and then passed through the beam splitter 104. The light 110c to be measured is, for example, first transmitted to the optical rotation measuring device 612 for measurement of the optical rotation information, and then entered into the energy measuring device 614 for measurement of the absorbed energy information. The optical rotation measuring device 616 and the energy measuring device 618 are used, for example, to measure the light 110d reflected by the eyeball 200, transmitted to the beam splitter 404 via the beam splitter 104, and reflected by the beam splitter 404. The light 110d to be measured is, for example, first transmitted to the optical rotation measuring device 616 for measurement of the optical rotation information, and then entered into the energy measuring device 618 for measurement of the absorbed energy information.

In this embodiment, the energy measuring devices 614, 618 are illustrated in two separate components. However, in another embodiment, the energy measuring devices 614, 618 can also be different sensing regions on the same photosensitive element, and the sensing of the light can be performed using different sensing regions on the photosensitive member.

Similarly, the portable mobile device 700 of the seventh embodiment can simultaneously analyze the optical change and the absorbed energy change between the light 110 emitted by the light source 102 and the light 110c, 110d transmitted to the photodetector group 606. And the glucose information (eg, glucose value) is measured, and since the glucose concentration in the eyeball (eg, the anterior chamber fluid in the eyeball) has a corresponding relationship with the blood glucose concentration, the non-invasive glucose monitoring by the present disclosure is transmitted through the correspondence relationship. The device detects glucose information (glucose concentration) in the eyeball (eg, anterior chamber fluid in the eyeball) and reads blood glucose information (eg, blood glucose level) with high accuracy. In addition, since the glucose monitoring function is integrated into the portable mobile device 700, it is quite convenient in use. In addition, the mobile device 700 can be connected to the cloud using a program or network of the portable mobile device 700 to provide remote medical care.

FIG. 8 is a schematic diagram of a portable mobile device having a non-invasive glucose monitoring function according to an eighth embodiment of the present disclosure.

Referring to FIG. 7 and FIG. 8 simultaneously, the portable mobile device 800 of the eighth embodiment differs from the portable mobile device 700 of the seventh embodiment in that, in the portable mobile device 800, the light 110 passes through the splitting light. The device 104 can generate two rays 110e, 110f, so there is no beam splitter 404 in the portable mobile device 700. In addition, the photodetector set 606 of the portable mobile device 800 has only one energy measuring device 614 without the energy measuring device 618. The energy measurement device 614 includes sensing regions 614a, 614b that can measure the absorbed energy information of the light rays 110e, 100f, respectively. The components, connection relationships, and functions of the other components of the portable mobile device 800 of the eighth embodiment are similar to those of the portable mobile device 700 of the seventh embodiment, and the eighth embodiment is similar to the seventh embodiment. The components are similar composition devices, and the monitoring method of glucose can refer to the Seven embodiments, so they are not described here.

In this embodiment, the light rays 110e, 100f are measured by the same energy measuring device 614. However, in another embodiment, the portable mobile device 800 can also measure the light rays 110e, 100f using two separate energy measuring devices.

It should be noted that, in the above embodiment, the light 110 is illustrated as being divided into two light rays 110e and 100f via the beam splitter 104, but is not intended to limit the disclosure. Referring to the above embodiments, those skilled in the art can understand that when the light ray 110 is split into two or more light beams via the beam splitter 104, the number of sensing regions on the energy measuring device 614 can be divided into two or more. Corresponding to the light from the beam splitter 104, the absorption energy information of the corresponding light can be separately measured.

Although, in this embodiment, more than two rays of light received by the energy measuring device 614 are generated via the beam splitter 104, it is not intended to limit the disclosure. In another embodiment, more than two light rays received by the energy measuring device 614 may also be formed by the light source 100, so that the light passing through the beam splitter 104 may be two or more, at this time on the energy measuring device 614. The number of sensing regions can also be divided into two or more, and the light from the beam splitter 104 can be respectively corresponding to the light, and the absorbed energy information of the corresponding light can be separately measured.

Similarly, the portable mobile device 800 of the eighth embodiment can simultaneously analyze the optical change and the absorbed energy change between the light 110 emitted by the light source 102 and the light 110e, 110f transmitted to the photodetector group 606. And the glucose information (eg, glucose value) is measured, and since the glucose concentration in the eyeball (eg, the anterior chamber fluid in the eyeball) has a corresponding relationship with the blood glucose concentration, the non-invasive glucose monitoring by the present disclosure is transmitted through the correspondence relationship. The device detects glucose information in the eyeball (eg, anterior chamber fluid in the eyeball) And read high-accuracy blood glucose information (eg, blood sugar level). In addition, since the glucose monitoring function is integrated into the portable mobile device 800, it is quite convenient in use. In addition, the mobile device 800 can be connected to the cloud to provide remote medical care, and the blood glucose data can be used to remind or control the medication. In case of an emergency, the medical unit can be directly notified for medical care.

FIG. 9 is a schematic diagram of a portable mobile device having a non-invasive glucose monitoring function according to a ninth embodiment of the present disclosure.

Referring to FIG. 7 and FIG. 9 simultaneously, the portable mobile device 900 of the ninth embodiment differs from the portable mobile device 700 of the seventh embodiment in the composition and seventh implementation of the optical package 904 of the ninth embodiment. The composition of the optical kit 604 is different. The optical package 904 is externally connected to the device body 602, and the optical package 904 includes a light source 102 and a beam splitter 404 in addition to the beam splitter 104 and the lens group 608, and optionally includes an optical information analyzing unit 116 and a warning device 118. . The components, connection relationships, and functions of the other components of the portable mobile device 900 of the ninth embodiment are similar to those of the portable mobile device 700 of the seventh embodiment, and the ninth embodiment is similar to the seventh embodiment. The components are similar composition devices, and the monitoring method of glucose can refer to the seventh embodiment, and thus will not be described herein.

Similarly, the portable mobile device 900 of the ninth embodiment can simultaneously analyze the optical change and the absorbed energy change between the light 110 emitted by the light source 102 and the light 110c, 110d transmitted to the photodetector group 606. And the glucose information (eg, glucose value) is measured, and since the glucose concentration in the eyeball (eg, the anterior chamber fluid in the eyeball) has a corresponding relationship with the blood glucose concentration, the non-invasive glucose monitor disclosed by the present disclosure is transmitted through the correspondence relationship. The measuring device detects glucose information (glucose concentration) in the eyeball (eg, anterior chamber fluid in the eyeball) and reads blood glucose information (eg, blood glucose level) with high accuracy. In addition, since the glucose monitoring function is integrated into the portable mobile device 900, it is quite convenient in use. In addition, remote medical care can be provided by connecting the cloud with the program or network of the portable mobile device 900.

It is to be noted that the concept of the external optical package 904 in the portable mobile device 900 of the ninth embodiment can also be applied to the sixth to eighth embodiments.

FIG. 10 is a schematic diagram of a portable mobile device having a non-invasive glucose monitoring function according to a tenth embodiment of the present disclosure.

Referring to FIG. 6 and FIG. 10 simultaneously, the portable mobile device 1000 of the tenth embodiment is different from the portable mobile device 600 of the sixth embodiment in the composition and the sixth implementation of the optical package 1004 of the tenth embodiment. The composition of the optical kit 604 is different. The optical package 1004 is externally connected to the lens 1006 of the portable mobile device 1000, and the optical package 1004 includes a beam splitter 104, a light source 102, and an optical rotation measuring device 612, and further optionally includes an optical information analyzing unit 116 and a warning device 118. . The light source 102, the optical rotation measuring device 612, and the optical information analyzing unit 116 can be coupled to the processing unit 108 in the most appropriate manner, and will not be described herein. The components, connection relationships, and functions of the other components of the portable mobile device 1000 of the tenth embodiment are similar to those of the portable mobile device 600 of the sixth embodiment, and the tenth embodiment is similar to the sixth embodiment. The components are similar constituent devices, and the monitoring method of glucose can refer to the sixth embodiment, and thus will not be described herein.

Optical measurement device 612 and energy measuring device when performing glucose measurement 614 is used, for example, to measure light 110 that is reflected by eyeball 200 and that passes through beam splitter 104. The light 110 to be measured is, for example, first transmitted to the optical rotation measuring device 612 for measurement of the optical rotation information, and then passes through the lens 1006, and then enters the energy measuring device 614 for measurement of the absorbed energy information.

Similarly, the portable mobile device 1000 of the tenth embodiment can simultaneously analyze the optical change and the absorbed energy change between the light 110 emitted by the light source 102 and the light 110 transmitted to the photodetector group 606, and The glucose information (eg, glucose value) is measured, and since the glucose concentration in the eyeball (eg, the anterior chamber fluid in the eyeball) has a corresponding relationship with the blood glucose concentration, the non-invasive glucose monitoring device of the present disclosure is detected by the corresponding relationship. Blood glucose information (eg, blood glucose level) with high accuracy is read by measuring glucose information (glucose concentration) in the eyeball (eg, anterior chamber fluid in the eyeball). In addition, since the glucose monitoring function is integrated into the portable mobile device 1000, it is quite convenient in use. In addition, the mobile device 1000 can be connected to the cloud using a program or network of the portable mobile device 1000 to provide remote medical care.

FIG. 11 is a schematic diagram of a portable mobile device having a non-invasive glucose monitoring function according to an eleventh embodiment of the present disclosure.

Referring to FIG. 10 and FIG. 11 simultaneously, the portable mobile device 1100 of the eleventh embodiment differs from the portable mobile device 1000 of the tenth embodiment in that, in the portable mobile device 1100, the light 110 passes through After the beam splitter 104, two rays 110g, 110h can be generated. In addition, the photodetector set 606 of the portable mobile device 1100 includes optical rotation measuring devices 612, 616 and an energy measuring device 614. Wherein, the energy measuring device 614 includes sensing regions 614c, 614d. Light rays 110g, 100h can be respectively measured by optical rotation measuring devices 612, 616 After the optical rotation information is measured, the absorbed energy information is measured by the sensing regions 614c, 614d of the energy measuring device 614, respectively. The components, connection relationships, and functions of the other components of the portable mobile device 1100 of the eleventh embodiment are similar to those of the portable mobile device 1000 of the tenth embodiment, and the eleventh and tenth embodiments The similar components are similar constituent devices, and the monitoring method of glucose can refer to the tenth embodiment, and thus will not be described herein.

In this embodiment, the light 110g, 100h is measured by the same energy measuring device 614. However, in another embodiment, the portable mobile device 1100 can also measure the light rays 110g, 100h using two separate energy measuring devices.

It should be noted that, in the above embodiment, the light 110 is illustrated as being divided into two light rays 110g and 100h via the optical splitter 104, but is not intended to limit the disclosure. Referring to the above embodiments, those skilled in the art can understand that when the light ray 110 is split into two or more light beams via the beam splitter 104, the number of sensing regions on the energy measuring device 614 can be divided into two or more. Corresponding to the light from the beam splitter 104, the absorption energy information of the corresponding light can be separately measured.

Although, in this embodiment, more than two rays of light received by the energy measuring device 614 are generated via the beam splitter 104, it is not intended to limit the disclosure. In another embodiment, more than two light rays received by the energy measuring device 614 may also be formed by the light source 100, so that the light passing through the beam splitter 104 may be two or more, at this time on the energy measuring device 614. The number of sensing regions can also be divided into two or more, and the light from the beam splitter 104 can be respectively corresponding to the light, and the absorbed energy information of the corresponding light can be separately measured.

Similarly, the portable mobile device 1100 of the eleventh embodiment can be simultaneously The optical light emitted by the light source 102 and the light changes 110g, 100h transmitted to the photodetector group 606 are analyzed for changes in optical rotation and absorption energy, and glucose information (eg, glucose value) is measured due to the eyeball (eg, The glucose concentration in the anterior chamber fluid in the eyeball has a corresponding relationship with the blood glucose concentration. Through this correspondence, the glucose information in the eyeball (eg, the anterior chamber fluid in the eyeball) is detected by the non-invasive glucose monitoring device disclosed herein. (Glucose concentration) and read blood glucose information (eg, blood glucose level) with high accuracy. In addition, since the glucose monitoring function is integrated into the portable mobile device 1100, it is quite convenient in use. In addition, the mobile device can be connected to the cloud using a program or network of the portable mobile device 1100 to provide remote medical care.

FIG. 12 is a schematic diagram of a portable mobile device having a non-invasive glucose monitoring function according to a twelfth embodiment of the present disclosure.

Referring to FIG. 7 and FIG. 12 simultaneously, the portable mobile device 1200 of the twelfth embodiment differs from the portable mobile device 700 of the seventh embodiment in that, in the portable mobile device 1200, the light 110 is split by light. After the reflector 404 reflects, two rays 110i, 110j are generated. In addition, the photodetector group 1206 of the portable mobile device 1200 includes a first photodetector 1208 and a second photodetector 1210, and the first photodetector 1208 and the second photodetector 1210 are located in the splitting. The same side of the device 404. In this embodiment, the first photodetector 1208 and the second photodetector 1210 are, for example, located on a side of the spectroscope 404 that reflects the light 110, and are respectively used to measure the light 110 generated by the beam splitter 404. Light rays 110i, 110j. One of the first photodetector 1208 and the second photodetector 1210 is, for example, an optical rotation measuring device for measuring optical rotation information, and the first photodetector 1208 and the second photodetector 1210 The other of them is, for example, an energy measuring device for measuring energy absorption information. In another In the embodiment, the first photodetector 1208 and the second photodetector 1210 may also include an optical rotation measuring device and an energy measuring device, respectively. The first photodetector 1208 and the second photodetector 1210 are coupled to the processing unit 108, for example, but are not intended to limit the disclosure. The components, connection relationships, and functions of the other components of the portable mobile device 1200 of the twelfth embodiment are similar to those of the portable mobile device 700 of the seventh embodiment, and the twelfth embodiment and the seventh embodiment The similar components are similar constituent devices, and the monitoring method of glucose can refer to the fourth embodiment, and thus will not be described herein.

In another embodiment, the first photodetector 1208 and the second photodetector 1210 may also be located on a side of the light 110 passing through the optical splitter 404, and used to measure the light 110 to penetrate the optical splitter 404, respectively. The two rays 110a, 100b are produced.

Similarly, the portable mobile device 1200 of the twelfth embodiment can simultaneously perform the optical change and the absorbed energy change between the light 110 emitted by the light source 102 and the light 110i, 110g transmitted to the photodetector group 1206. Analysis, and the measured glucose information (eg, glucose value), because the glucose concentration in the eyeball (eg, the anterior chamber fluid in the eyeball) has a corresponding relationship with the blood glucose concentration, through the corresponding relationship, the non-invasive glucose by the present disclosure The monitoring device detects glucose information (glucose concentration) in the eyeball (eg, anterior chamber fluid in the eyeball) and reads blood glucose information (eg, blood glucose level) with high accuracy. In addition, since the glucose monitoring function is integrated into the portable mobile device 1200, it is quite convenient in use. In addition, the mobile device 800 can be connected to the cloud to provide remote medical care, and the blood glucose data can be used to remind or control the medication. In case of an emergency, the medical unit can be directly notified for medical care.

Figure 13 is a diagram showing a non-invasive grape of the thirteenth embodiment of the present disclosure. Schematic diagram of a portable mobile device for sugar monitoring functions.

Referring to FIG. 12 and FIG. 13 simultaneously, the portable mobile device 1300 of the thirteenth embodiment is different from the portable mobile device 1200 of the twelfth embodiment in that the composition of the optical package 1304 of the thirteenth embodiment is The composition of the optical kit 1204 of the twelfth embodiment is different. The optical package 1304 is externally connected to the device body 602, and the optical package 1304 includes a light source 102 and a beam splitter 404 in addition to the beam splitter 104 and the lens group 608, and optionally includes an optical information analyzing unit 116 and a warning device 118. . The components, connection relationships, and functions of the other components of the portable mobile device 1300 of the thirteenth embodiment are similar to those of the portable mobile device 1200 of the twelfth embodiment, and the thirteenth embodiment and the twelfth embodiment Similar components in the embodiment are similar constituent devices, and the monitoring method of glucose can refer to the twelfth embodiment, and thus will not be described herein.

Similarly, the portable mobile device 1300 of the thirteenth embodiment can simultaneously perform the optical change and the absorbed energy change between the light 110 emitted by the light source 102 and the light 110i, 110j transmitted to the photodetector group 606. Analysis, and the measured glucose information (eg, glucose value), because the glucose concentration in the eyeball (eg, the anterior chamber fluid in the eyeball) has a corresponding relationship with the blood glucose concentration, through the corresponding relationship, the non-invasive glucose by the present disclosure The monitoring device detects glucose information (glucose concentration) in the eyeball (eg, anterior chamber fluid in the eyeball) and reads blood glucose information (eg, blood glucose level) with high accuracy. In addition, since the glucose monitoring function is integrated into the portable mobile device 1300, it is quite convenient in use. In addition, the mobile device can be connected to the cloud using a program or network of the portable mobile device 1300 to provide remote medical care.

In addition, although non-invasive glucose monitoring devices are used in portable mobile devices The sixth embodiment to the thirteenth embodiment are described as an example, but are not intended to limit the disclosure. A portable mobile device with non-invasive glucose monitoring function disclosed in the sixth to thirteenth embodiments can be portable in the field of non-invasive glucose monitoring. The concept of the device is combined with the various embodiments of the first to fourth embodiments to develop a variety of portable mobile devices with non-invasive glucose monitoring functions.

In addition, although the first embodiment to the thirteenth embodiment are described by taking an eye as an example, it is not intended to limit the disclosure. Those skilled in the art can refer to the disclosure of the above embodiments to find an embodiment in which the disclosure is applied to both eyes.

FIG. 14 is a schematic view showing a method for analyzing biochemical molecules according to a fourteenth embodiment of the present disclosure.

In this embodiment, the analysis method of the biochemical molecule is, for example, analyzed by a processing unit of the biochemical molecular monitoring device. The biochemical molecules to be analyzed are, for example, glucose, cholesterol, uric acid, water, lactic acid, urea, ascorbic acid or a combination thereof. The biochemical molecular monitoring device is, for example, the non-invasive glucose monitoring device of the first to fourth embodiments described above and the portable mobile device having the non-invasive glucose monitoring function according to the sixth to thirteenth embodiments. At least one of them.

Referring to FIG. 14, step S202 can be performed to obtain an optical rotation change. The method of obtaining an optical rotation change includes the following steps. First, the portion of the plurality of optical rotation change values measured by the biochemical molecular monitoring device that exceeds the acceptable variation range is discarded. Next, the value of the optical rotation change is calculated using at least one mathematical statistical method. Among them, the mathematical statistical method is, for example, Least square error regression analysis. The acceptable range of variation is, for example, a range expressed by the following mathematical formula.

Acceptable variation range of optical rotation change = arithmetic mean of optical rotation change value × (1 ± 15%)

Further, step S204 may be performed to obtain an absorption energy change. A method of obtaining a change in absorbed energy includes the following steps. First, the portion of the plurality of absorbed energy change values measured by the biochemical molecular monitoring device that exceeds the acceptable variation range is discarded. Next, the value of the absorbed energy change is calculated using at least one mathematical statistical method. Among them, the mathematical statistical method is, for example, a least square error regression analysis method. The acceptable range of variation is, for example, a range expressed by the following mathematical formula.

Acceptable range of variation in absorbed energy = arithmetic mean of the value of absorbed energy change × (1 ± 15%)

Step S206 is performed to establish at least a first polynomial equation of the relationship between the biochemical molecule and the optical rotation change and at least a second polynomial equation of the relationship between the biochemical molecule and the absorbed energy. The biochemical molecule includes a target molecule and at least one interfering molecule, and the plurality of variables of the first polynomial equation and the second polynomial equation respectively include a target molecule concentration variable and an interference molecule concentration variable.

The first polynomial equation is established, for example, by a plurality of biochemical molecular concentration values stored in the database and corresponding plurality of optical rotation change values. The second polynomial equation is, for example, established by a plurality of biochemical molecular concentration values stored in the database and corresponding plurality of absorbed energy change values. The sample body of the plurality of biochemical molecular concentration values stored in the database includes a plurality of living samples or a plurality of standard samples.

In addition, the steps of establishing the first polynomial equation and the second polynomial equation further comprise distinguishing a plurality of optical rotation variation ranges from the plurality of absorption energy variation ranges, and having the first plurality of corresponding use in each of the optical rotation variation ranges The equation has a second polynomial equation that is used correspondingly in each range of absorbed energy variations.

For example, when the target molecule is glucose and the interfering molecule is lactic acid, and the range of three optical rotations and the range of three absorption energies are distinguished, the first polynomial equation and the second polynomial equation are selected as follows. Show, but this disclosure is not limited to this.

The first polynomial equation used in the first range of optical rotation: θ _{(glucose effect + lactic acid effect)} = a ₁ X _{glucose concentration} + b ₁ Y _{lactic acid concentration} + c ₁

The first polynomial equation used in the second range of optical rotation: θ _{(glucose effect + lactic acid effect)} = a ₁ 'X _{glucose concentration} + b ₁ 'Y _{lactic acid concentration} + c ₁ '

The first polynomial equation used in the third range of optical rotation: θ _{(glucose effect + lactic acid effect)} = a ₁ "X _{glucose concentration} + b ₁ "Y _{lactic acid concentration} + c ₁ "

Among them, θ _{(glucose effect + lactic acid influence)} is an optical rotation change, X _{glucose concentration} is a target molecular concentration variable, and Y _{lactic acid concentration} is an interference molecule concentration variable, a ₁ , a ₁ ', a ₁ ", b ₁ , b ₁ ', b ₁ ", c ₁ , c ₁ ' and c ₁ " are known coefficients.

The second polynomial equation is used in the range of the first absorbed energy variation: P _{(glucose effect + lactic acid influence)} = a ₂ X _{glucose concentration} + b ₂ Y _{lactic acid concentration} + c ₂

The second polynomial equation is used in the range of the second absorbed energy variation: P _{(glucose effect + lactic acid influence)} = a ₂ 'X _{glucose concentration} + b ₂ 'Y _{lactic acid concentration} + c ₂ '

The second polynomial equation is used in the range of the third absorbed energy variation: P _{(glucose effect + lactic acid influence)} = a ₂ "X _{glucose concentration} + b ₂ "Y _{lactic acid concentration} + c ₂ "

Among them, P _{(glucose effect + lactic acid effect)} is an optical rotation change, X _{glucose concentration} is a target molecular concentration variable, Y _{lactic acid concentration} is an interference molecule concentration variable, a ₂ , a ₂ ', a ₂ ", b ₂ , b ₂ ', b ₂ ", c ₂ , c ₂ ' and c ₂ " are known coefficients.

Step S208 is performed to bring the change of the optical rotation and the absorption energy measured by the biochemical molecular monitoring device into the first polynomial equation and the second polynomial equation to calculate the simultaneous presence of the target molecule and the interference molecule. The first target molecule concentration of the target molecule. The calculation method of the first target molecular concentration is, for example, solving the simultaneous equations of the first polynomial equation and the second polynomial equation. In the process of performing step S208, the change of the optical rotation and the change of the absorbed energy can be further analyzed by controlling the change factor to obtain the first target molecular concentration. The change factor includes a light emission frequency, a light energy intensity, a light on time length, a light off time length, a optomechanical space offset, or a combination thereof.

Further, steps S210, S212, S214, S216, S218, or a combination thereof are more selectively performed.

In step S210, at least a first graph or at least a third polynomial equation of the biochemical molecule relationship with the optical rotation change is established. Wherein, the variable of the third polynomial equation includes a target molecule concentration variable.

The first graph and the third polynomial equation are, for example, established by a plurality of biochemical molecular concentration values stored in the database and corresponding plurality of optical rotation change values. The sample body of the plurality of biochemical molecular concentration values stored in the database includes a plurality of living samples or a plurality of standard samples.

In addition, the step of establishing the first graph or the third polynomial equation further comprises distinguishing a plurality of optical rotation variation ranges, and having the first corresponding use in each optical rotation variation range Chart, third polynomial equation, or a combination thereof.

For example, when the target molecule is glucose and three optical rotation ranges are distinguished, the third polynomial equation selected is as follows, but the disclosure is not limited thereto.

The third polynomial equation used in the first range of optical rotation: θ _{(glucose effect)} = a ₃ X _{glucose concentration} + c ₃

The third polynomial equation used in the second range of optical rotation: θ _{(glucose effect)} = a ₃ 'X _{glucose concentration} + c ₃ '

The third polynomial equation used in the third range of optical rotation: θ _{(glucose effect)} = a ₃ "X _{glucose concentration} + c ₃ "

Wherein θ _{(glucose effect)} is an optical rotation change, X _{glucose concentration} is a target molecular concentration variable, and a ₃ , a ₃ ', a ₃ ", c ₃ , c ₃ ' and c ₃ " are known coefficients.

In step S212, the optical rotation change measured by the biochemical molecular monitoring device is brought into the first chart, the third polynomial equation, or a combination thereof to calculate the second target molecular concentration of the target molecule. In the process of performing step S212, the optical rotation change can be analyzed by controlling the change factor to obtain the second target molecular concentration. The change factor includes a light emission frequency, a light energy intensity, a light on time length, a light off time length, a optomechanical space offset, or a combination thereof.

In step S214, at least a second chart or at least a fourth polynomial equation of the relationship between the biochemical molecule and the absorbed energy is established. Wherein, the variable of the fourth polynomial equation includes a target molecule concentration variable.

The second and fourth polynomial equations are, for example, stored in the database. A plurality of biochemical molecular concentration values are established corresponding to a plurality of corresponding absorption energy change values. The sample body of the plurality of biochemical molecular concentration values stored in the database includes a plurality of living samples or a plurality of standard samples.

Furthermore, the step of establishing the second graph or the fourth polynomial equation further comprises distinguishing a plurality of ranges of absorbed energy variations, and having a second graph, a fourth polynomial equation or a correspondingly used equation for each absorbed energy variation range or combination.

For example, when the target molecule is glucose and the three ranges of absorbed energy are distinguished, the fourth polynomial equation selected is as follows, but the disclosure is not limited thereto.

The fourth polynomial equation used in the first range of absorbed energy variations: P _{(glucose effect)} = a ₄ X _{glucose concentration} + c ₄

The fourth polynomial equation used in the second range of absorbed energy variations: P _{(glucose effect)} = a ₄ 'X _{glucose concentration} + c ₄ '

The fourth polynomial equation used in the third range of absorbed energy variations: P _{(glucose effect)} = a ₄ "X _{glucose concentration} + c ₄ "

Among them, P _{(glucose effect)} is a change in absorbed energy, X _{glucose concentration} is a target molecule concentration variable, and a ₄ , a ₄ ', a ₄ ", c ₄ , c ₄ ' and c ₄ " are known coefficients.

In step S216, the absorption energy change measured by the biochemical molecular monitoring device is brought into the second graph, the fourth polynomial equation or a combination thereof to calculate the target score. The third target molecule concentration of the child. In the process of performing step S216, the absorption energy change can be analyzed by controlling the change factor to obtain the third target molecule concentration. The change factor includes a light emission frequency, a light energy intensity, a light on time length, a light off time length, a optomechanical space offset, or a combination thereof.

In step S218, the final target molecular concentration is determined from the first target molecular concentration, the second target molecular concentration, the third target molecular concentration, or a combination thereof. In another embodiment, when step S218 is not performed, the first target molecular concentration obtained in step S208 can be taken as the final target molecular concentration.

As can be seen from the above-described fourteenth embodiment, the above-described biochemical molecular analysis method can obtain a target molecule concentration when both the target molecule and the interfering molecule are present by the change in the optical rotation and the absorption energy, and thus a more accurate target molecule concentration can be obtained.

[Example]

The relationship between the energy absorption of glucose and other substances such as urea, water, and vitamins in the anterior chamber fluid is as described in the equation (1).

A _sum = A _glucose + [A _vitamin + A _i +...] = ε ₁ bc ₁ + [ε ₂ bc ₂ + ε ₃ bc ₃ +...] (1)

The optical rotation angle relationship of glucose and other substances such as urea, water, and vitamins in the anterior chamber fluid is as described in the equation (2).

θ _sum = θ _glucose + [θ _vitamin + θ _i +...] = Φ ₁ bc ₁ + [Φ ₂ bc ₂ + Φ ₃ bc ₃ +...] (2)

A _total : The total energy absorption of the anterior chamber fluid measured by the biochemical molecular monitoring device; A _glucose , A _vitamin , A _i : energy absorption of glucose, vitamins and other different components in the anterior chamber fluid; θ _sum : The biochemical molecular monitoring device measures the total optical rotation angle of the anterior chamber fluid; θ _glucose , θ- _vitamin , θ _i : representing the optical rotation angle of glucose, vitamins and other components in the anterior chamber fluid; ε ₁ , ε ₂ , ε ₃ ...: molar absorptivity of each substance, usually in units of M ^-1 cm ^-1 ; b: light path, usually in units of cm ^-1 ; c ₁ , c ₂ , c ₃ . ..: the molar concentration of each substance, usually in units of M; Φ ₁ , Φ ₂ , Φ ₃ ...: The theoretical optical rotation angle coefficient of each substance, usually in units of M ^-1 cm ^-1 .

Assume that the anterior chamber fluid contains two components, one of which is glucose, the energy absorption of _glucose is A _glucose , and the other component is vitamin. The energy absorption of _vitamin is A _vitamin , then the original formula (1) (2) The medium can be reduced to: A _sum = A ₁ × c _glucose + A ₂ × c _vitamin + constant C ₁ ... (3)

θ _sum = B ₁ × c _glucose + B ₂ × c _vitamin + constant C ₂ ... (4)

Wherein, A ₁ , A ₂ ... represent the ratio of the energy absorption of different constituents in the anterior chamber fluid, respectively, and B ₁ , B ₂ ... represent the optical rotation angles of different constituent components in the anterior chamber fluid, respectively. proportion.

To simplify the description, assuming that the composition of the anterior chamber contains only two unknown concentrations of glucose and vitamins, and the path length is b, then A ₁ represents the energy absorption of glucose as a percentage of total energy absorbance at a fixed optical path b. For example; A ₂ represents a percentage of the energy absorbance of vitamins as a percentage of the total energy absorbance at a fixed optical path b; B ₁ represents the percentage of the optical rotation produced by glucose at a fixed optical path b as a percentage of the total optical rotation angle For example; B ₂ represents a percentage of the optical rotation angle produced by vitamins as a percentage of the total optical rotation angle at a fixed optical path b; c _glucose : molar concentration of glucose; c _vitamin : molar concentration of vitamins.

Bring the measured values into equations (3) and (4), and equations (3) and (4) can be changed to equations (5) and (6).

7.5=0.1×c _glucose +0.2× _cvitamin +0.5...(5)

46.1=0.9×c _glucose +0.1× _cvitamin +0.1...(6)

In order to reduce the interference of noise (such as temperature..), the calculation of the absorption concentration and the optical rotation angle value of a single object to be tested is corrected according to the laser controlled by the feedback mechanism. Finally, each absorbance or optical rotation angle value measured after correction by the feedback mechanism can be obtained by equations (5) and (6) with a glucose concentration of 50 mg/dL and a vitamin concentration of 10 mg/dL.

From this, it can be seen that the concentration of two different substances can be discriminated by the above method. This logic algorithm can determine the situation of glucose and at least one mixture in the anterior chamber fluid if the characteristics of absorption and rotation angle of different interferents are matched at the same time. In addition, according to the absorption concentration and the optical rotation angle calculated by the feedback mechanism, the interference of environmental noise can also be avoided.

In summary, the above embodiment has at least the following features. The non-invasive glucose monitoring device proposed in the above embodiment can accurately measure the glucose information (eg, glucose value) of the measurement object due to the glucose concentration in the eyeball (eg, the anterior chamber fluid in the eyeball). The blood glucose concentration has a corresponding relationship, and through this correspondence, the non-invasiveness of the present disclosure The glucose-incorporated monitoring device detects glucose information (glucose concentration) in the eyeball (eg, anterior chamber fluid in the eyeball) and reads blood glucose information (eg, blood glucose level). The non-invasive glucose monitoring device proposed in the above embodiments can be used for miniaturization, thereby improving the convenience of use. The portable mobile device having the non-invasive glucose monitoring function proposed in the above embodiment is not particularly limited in use, and can be used indoors or outdoors. The blood glucose level of the measurement subject can be continuously and instantaneously obtained by the non-invasive glucose monitoring method proposed in the above embodiment. The method for analyzing biochemical molecules proposed in the above embodiments can obtain the target molecule concentration when the target molecule and the interfering molecule are present simultaneously by the change of the optical rotation and the absorption energy, so that a more accurate concentration of the target molecule can be obtained. In addition, when the non-invasive glucose monitoring device proposed in the above embodiment has a reference component, the light intensity change caused by the environmental influence can be excluded to obtain more accurate glucose information, thereby improving blood sugar information (eg, blood sugar level). Accuracy. In addition, when the non-invasive glucose monitoring device proposed in the above embodiment has an eye positioning device, the measurement error caused by the light not falling at the correct eye measurement position can be avoided, thereby making the non-invasive glucose monitoring device Get more accurate glucose information to improve the accuracy of blood glucose information (eg, blood glucose values).

The present disclosure has been disclosed in the above preferred embodiments. However, it is not intended to limit the scope of the disclosure, and the invention may be modified and modified without departing from the spirit and scope of the disclosure. The scope of protection is subject to the definition of the scope of the patent application.

100‧‧‧ Non-invasive glucose monitoring device

102, 142‧‧‧ light source

104, 130, 138, 146‧‧ ‧ beamsplitter

106‧‧‧Photodetector group

108‧‧‧Processing unit

110, 144‧‧‧ rays

112‧‧‧Aperture measuring device

115‧‧‧Light barrier

115a‧‧ hole

114‧‧‧ Energy measuring device

116‧‧‧Light Information Analysis Unit

118‧‧‧ warning device

124‧‧‧Connecting components

126‧‧‧ sheath

128‧‧‧Reference components

132, 134‧‧ ‧ shutter

136‧‧‧ eye positioning device

140‧‧‧ camera

148‧‧‧Lens system

150‧‧ Sight

200‧‧‧ eyeballs

202‧‧‧ front room

204‧‧‧After room fluid

Claims (20)

A non-invasive glucose monitoring device comprising: at least one light source emitting at least one light; a first optical splitter having a focusing function for causing the light emitted by the light source to be incident and focused by the first optical splitter a light detector group, measuring an optical rotation information and an absorption energy information of the light reflected by the eyeball and transmitted to the photodetector group by the first beam splitter; Receiving, by the reference component, the light from the first beam splitter, and the light reflected by the reference component is transmitted to the photodetector group by the first beam splitter, wherein the light emitted by the light source is used by the light source The first beam splitter and the eyeball are sent to the photodetector group to form a first optical path, and the light emitted by the light source is transmitted to the photodetector by the first beam splitter and the reference component. Forming a second optical path; and a processing unit receiving and processing the optical rotation information and the absorbed energy information to obtain a glucose information. The non-invasive glucose monitoring device of claim 1, wherein the light reflected by the reference element on the second optical path has a characteristic intensity. The non-invasive glucose monitoring device of claim 2, wherein the photodetector group obtains a reference intensity of the light reflected by the reference element from the second optical path when actually measuring. The non-invasive glucose monitoring device of claim 3, wherein the light emitted by the light source and the light transmitted to the photodetector group are obtained from the first optical path by the processing unit. An optical rotation change and an absorption energy change Comparing the characteristic intensity with the reference intensity, and eliminating a light intensity change caused by the environmental influence, obtaining a biochemical molecular information of the biochemical molecule, the biochemical molecule includes at least one glucose, and the processing unit uses the biochemical molecular information The glucose information is obtained, and the blood glucose information is read out because the glucose information has a correspondence with the blood glucose information. The non-invasive glucose monitoring device of claim 1, wherein the reference component comprises a reference sheet or a reference solution. The non-invasive glucose monitoring device of claim 1, wherein the reference component comprises a light absorbing material, a reflective light material or a solution. The non-invasive glucose monitoring device of claim 1, further comprising an optical information analyzing unit that detects a light information of the light from the first beam splitter before the light is incident on the eyeball And transmitting the optical information to the processing unit, a warning device or a light source control unit to perform feedback control on an optical characteristic of the light. The non-invasive glucose monitoring device of claim 7, wherein the optical information analysis unit comprises at least one of an optical power meter and a light sensor, the light detected by the optical power meter The information is an energy information, and the light information detected by the light sensor is at least one of the energy information and a location information. The non-invasive glucose monitoring device of claim 7, further comprising a second beam splitter, wherein the light from the first beam splitter is separately transmitted to the reference component and the optical information analyzing unit. The non-invasive glucose monitoring device of claim 7, further comprising a first shutter disposed on the first optical path between the first beam splitter and the eyeball. Such as the non-invasive glucose monitoring device described in claim 7 of the patent scope, A second shutter is disposed on the second optical path between the first beam splitter and the reference component. The non-invasive glucose monitoring device of claim 1, wherein a wavelength of the light source comprises a glucose absorbable wavelength. The non-invasive glucose monitoring device of claim 1, wherein a wavelength of the light source comprises a wavelength in the infrared light. The non-invasive glucose monitoring device of claim 1, wherein the light comprises a linearly polarized light, a circularly polarized light, an elliptically polarized light or a partially polarized light. The non-invasive glucose monitoring device of claim 1, wherein the first beam splitter focuses the light to an anterior chamber of the eyeball, and the light reflected by the eyeball includes light from a front room The reflected light of the liquid. The non-invasive glucose monitoring device of claim 1, wherein the first beam splitter comprises an optical film, a lens, a grating, a diffractive optical element or a combination of any of the above. The non-invasive glucose monitoring device of claim 1, wherein the photodetector group comprises an optical rotation measuring device and an energy measuring device, respectively measuring the reflection by the eyeball, and then The first beam splitter reflects or re-passes the light of the first beam splitter. The non-invasive glucose monitoring device of claim 1, further comprising a third beam splitter, wherein the light reflected by the eyeball and transmitted by the first beam splitter is transmitted to the light detector group. The non-invasive glucose monitoring device of claim 18, wherein the photodetector group comprises a first photodetector and a second photodetector, respectively for measuring the third The light reflected or passed through the third beam splitter by the beam splitter. The non-invasive glucose monitoring device according to claim 1, further comprising an eye aiming positioning device for aligning the line of sight of an eye with the positioning device for eye sighting to determine an eyeball Measuring position.