TWI513484B - Multi-channel electronic stimulator for spinal cord stimulation - Google Patents

Description

Multi-channel spinal cord stimulation generator

The present invention relates to a spinal cord electrical stimulation generator, and more particularly to a multi-channel spinal cord electrical stimulation generator that can adjust the amplitude and frequency of a stimulation wave.

Generally, implantable micro stimulators are widely used to treat various physiological pains and neuropathic pains, and electrical stimulation is used to block the transmission of body pain signals through the spinal cord to the brain to greatly reduce pain.

Referring to FIG. 8 , a conventional electrical stimulation generator 200 has a power supply unit 210 , a voltage conversion unit 220 , a control unit 230 , a protection component 240 , an energy storage component 250 , a current direction control switch 260 , and An output coil 270 is configured to provide a current. The voltage conversion component 220 is electrically connected to the power supply unit 210 to convert the current into a rated voltage of the electrical stimulation generator 200. The control unit 230 The protection component 240 is electrically connected to the voltage conversion unit 220, and the energy storage unit 250 is electrically connected to the control unit 230 and is controlled by the control unit 230, and The current direction control switch 260 receives the rated voltage to output a stimulation current to the output coil 270. Since the current direction control switch 260 is controlled by the control unit 230 only in the conventional electrical stimulation generator 200 to adjust the stimulation current. Polarity direction, but the amplitude, frequency and pulse width of the stimulation current cannot be adjusted, and since the electrical stimulation generator 200 is composed of discrete components Therefore, the volume of the electrical stimulation generator 200 is large, and therefore, if the electrical stimulation generator 200 is used for implantable treatment, it is liable to cause discomfort to the user.

The main purpose of the present invention is to provide an amplitude control signal, a channel selection signal and a stimulus type signal to a digital analog conversion circuit, a sampling circuit and a stimulus waveform generator by a control circuit, so that the digital analog conversion circuit outputs an amplitude signal according to the amplitude control signal to The sampling circuit, the sampling circuit receives the channel selection signal and the amplitude signal, and then outputs a stable voltage signal to the stimulation waveform generator, and through the control of the channel selection signal, the channel for outputting the voltage signal is determined, and the stimulation waveform generator receives the stimulation type. After the signal and the voltage signal, the stimulation waveform is output for the treatment of the electrical stimulation, wherein the stimulation waveform generator can adjust the amplitude of the stimulation waveform by the voltage signal, and adjust the frequency, polarity and pulse width of the stimulation waveform by the stimulation type signal. The multi-channel spinal cord electrical stimulation generator is more widely used, and since the electronic components of the present invention are integrated into an integrated circuit, the volume of the multi-channel spinal cord electrical stimulation generator is greatly reduced to prevent the user from using it during use. Discomfort.

A multi-channel spinal cord electrical stimulation generator comprises a control circuit, a digital analog conversion circuit, a sampling circuit and a plurality of stimulation waveform generators, wherein the control circuit outputs an amplitude control signal, a channel selection signal and a plurality of stimulation type signals The digital analog conversion circuit is electrically connected to the control circuit to receive the amplitude control signal, and the digital analog conversion circuit outputs an amplitude signal, wherein the amplitude control signal is used to determine the magnitude of the amplitude signal, and the sampling circuit has a plurality of And the plurality of sampling components, the multiplexer is electrically connected to the control circuit to receive the channel selection signal, and the multiplexer outputs a plurality of selection signals, each of the sampling components being electrically connected to the digital analog conversion circuit and the a multiplexer for receiving the amplitude signal and each of the selection signals, and each of the sampling elements outputs a voltage signal, wherein each of the selection signals is used to determine whether each of the sampling elements is turned on or off, and the amplitude signal is used to determine the The magnitude of the voltage signal, each of the stimulation waveform generators has an operational amplifier and an analog switch Each of the operational amplifiers is electrically connected to each of the sampling elements to receive each of the voltage signals, and each of the operational amplifiers outputs an amplified voltage signal, and each of the analog switches is electrically connected to each of the operational amplifiers and the control circuit to receive each of the amplification signals. The voltage signal and the stimulus type signal, and each of the analog switches outputs a stimulation wave, wherein each of the amplified voltage signals is used to determine the magnitude of each of the stimulation waves, and each of the stimulation type signals is used to determine the frequency of each of the stimulation waves.

The multi-channel spinal cord electrical stimulation generator outputs a plurality of the stimulation waves capable of adjusting amplitude, frequency, polarity and pulse width to perform different types of electrical stimulation treatment, and since the components of the present invention are integrated into one In the integrated circuit, the volume of the multi-channel spinal cord electrical stimulation generator is reduced, and the power consumption of the multi-channel spinal cord electrical stimulation generator can be reduced to reduce the user's discomfort to the implanted device.

Referring to FIG. 1 , a multi-channel spinal cord electrical stimulation generator 100 includes a control circuit 110 , a digital analog conversion circuit 120 , a sampling circuit 130 , and a plurality of stimulation waveform generators 140 . A booster circuit 150 and a plurality of electrodes 160.

Referring to FIGS. 1 and 2 , the digital analog conversion circuit 120 is electrically connected to the control circuit 110 , and the digital analog conversion circuit 120 receives an amplitude control signal ACS output by the control circuit 110 , and the digital analog conversion circuit 120 The amplitude control signal ACS outputs an amplitude signal DAC_out, and the amplitude control signal ACS is used to determine the size of the amplitude signal DAC_out. Referring to FIG. 2, in the embodiment, the digital analog conversion circuit 120 is an 8-bit current steering. An 8-bit current-steering DAC, the digital-to-analog converter circuit 120 has eight sets of current switch groups 121, a buffer 122, and a grounding resistor 123. Each of the current switch groups 121 has a current source 121a and a current switch 121b, each of the current switch 121b is electrically connected between each of the current source 121a and the buffer 122, so that the current source 121a and the buffer 122 are turned on or off, and the current source is 121a and each of the current switches 121b are P-type transistors, and the gate terminals of the current sources 121a receive a 1.8 V DC bias dac_vbias, and the source terminals of the current sources 121a receive a voltage of 2.5 V. a source VDD, each of the current sources 121a is electrically connected to a source terminal of each of the current switches 121b, and a gate terminal of each of the current switches 121b receives the inverted amplitude control signal ACS, and the current terminal of each of the current switches 121b The buffers 122 are electrically connected. Preferably, the size of the eight sets of current sources 121a are designed according to binary weights, and the sizes of the right-to-left current sources 121a are designed as 1, 2, 4, 8, 16, 32, respectively. And 64 and 128 units, the amplitude control signal ACS is an 8-bit signal (ACS0 to ACS7), and each of the current switches 121b is electrically connected to the control circuit 100 and receives the amplitude control signal (ACS0 to ACS7). Each of the signal bits of the control signal controls each of the current switches 121b to determine whether each of the current switches 121b is turned on or off. If the amplitude control signal ACS only turns on the rightmost current switch 121b, the rightmost current source 121a is Output 1 unit of current to the buffer 122. If the amplitude control signal ACS simultaneously turns on the right three current switches 121b, the three current sources 121a on the right side output currents of 1 unit, 2 units, and 4 units, respectively. The buffer 1 22, and the buffer 122 receives 7 units of current, and so on, the current sources 121a thereby providing a linearly varying current controlled by the amplitude control signal ACS to the buffer 122. In addition, the grounding resistor The current switch 121b and the buffer 122 are electrically connected to the current switch 121b and the buffer 122, and the inverting input end of the buffer 122 is connected to the output end of the buffer 122 to form a negative feedback to enhance the current. The buffer 122 is linearly changed. The amplitude output of the current is linearly changed by the amplitude signal DAC_out.

Referring to FIGS. 1 and 3, the sampling circuit 130 has a multiplexer 131 and a plurality of sampling elements 132. The multiplexer 131 is electrically connected to the control circuit 110 to receive the channel selection signal CSS, and the multiplexer 131 outputs a plurality of selection signals SS. Referring to FIG. 3, in the embodiment, the multiplexer 131 is a 4-to-16 decoder, and the multiplexer 131 receives 4-bits. The channel selects signals (CSS[0] to CSS[3]) and outputs the selection signals (SS0 to SS15) of 16 bits to the sampling elements 132 of the 16 groups, respectively, by selecting the signals of the bits (SS0 to SS15) controlling each of the sampling elements 132, each of the sampling elements 132 is electrically connected to the digital analog conversion circuit 120 and the multiplexer 131 to receive the amplitude signal DAC_out and each of the selection signals (SS0 to SS15), and each of the The sampling component 132 outputs a voltage signal (SH_out_0 to SH_out_15), wherein each of the selection signals (SS0 to SS15) is used to determine whether each sampling component 132 is turned on or off. The amplitude signal DAC_out is used to determine the voltage signals SH_out. For the size, please refer to FIG. 3. In this embodiment, each of the sampling circuits 130 The sample element 132 has a voltage switch 132a, a capacitor 132b and a gain buffer 132c. The voltage switch 132a is electrically connected between the digital analog conversion circuit 120 and each of the gain buffers 132c to enable the digital analog conversion circuit. 120 and each of the gain buffers 132c are turned on or off. Each of the capacitors 132b is coupled to the digital analog conversion circuit 120. When each of the selection signals (SS0 to SS15) is high, the voltage switches 132a are turned on. Each of the gain buffers 132c and the digital analog conversion circuit 120 is turned on, and each of the capacitors 132b receives the amplitude signal DAC_out to store the magnitude of the amplitude signal DAC_out. Therefore, when each of the voltage switches 132a is turned off, each of the voltage switches 132a is turned off. The capacitor provides a voltage of the same magnitude as the amplitude signal DAC_out in each of the gain buffers 132c.

Referring to FIG. 3, each of the sampling circuits further has an inverter 132d, a redundant switch 132e and a reset switch 132f. Each of the inverters 132d is electrically connected to the multiplexer 131 and Between each of the redundant switches 132e, the inverter 132d receives the selection signals (SS0 to SS15) of the multiplexer 131 and provides an inverted reference signal to the redundant switch 132e. The redundant switch Each of the voltage switches 132a is electrically connected to the voltage switch 132a. Since each of the redundant switches 132e receives the selection signal for inversion, when the voltage switches 132a are turned off, the redundant switches 132e are turned on to avoid charge injection. The charge injection affects the output of each of the gain amplifiers 132c of the back end, and the gate terminals of the reset switches 132f receive a reset signal rst, and the reset switches 132f are electrically connected to the capacitors 132b. The source terminals of the reset switches 132f are grounded. When the reset signals rst received by the reset switches 132f are high, the reset switches 132f are turned on, so that the capacitors 132b are discharged to a low level. Potential, to prevent each of the reset switches 132f from being turned on again, Each of the capacitors 132b cannot store the magnitude of the amplitude signal DAC_out.

Referring to Figures 1 and 4, since the multi-channel spinal cord stimulation generator 100 receives a voltage source of low voltage (2.5 V), the voltage of the low voltage (2.5 V) is not available for the back end. The stimulation waveform generator 140 is used. In the embodiment, the boosting circuit 150 performs boosting, the boosting circuit 150 receives the DC voltage Vcp_in, and the boosting circuit 150 is electrically connected to each of the stimulation waveform generators. 140, the boost circuit 150 boosts the low voltage DC voltage (2.5 V) to a high voltage (greater than 14.7 V) and provides a boost voltage Vcp_out (greater than 14.7 V) to each of the stimulation waveform generators 140, or In other embodiments, the multi-channel spinal cord electrical stimulation generator 100 can directly provide voltage sources of different amplitude voltages. Referring to FIG. 4, in the embodiment, a 5-level charge pump circuit is used ( The boosting circuit 150 has five boosting elements 151 and an inverter 152. Each of the boosting elements 151 has a first capacitor 151a, a second capacitor 151b, and a first capacitor. a crystal 151c, a second transistor 151d, a third transistor 151e, and a a fourth transistor 151f, a first node n1, a second node n2, a third node n3, and a fourth node n4. The first capacitor 151a is electrically connected to the third node n3, and the first capacitor 151a receives a clock signal clk, the second capacitor 151b is electrically connected between the inverter 152 and the second node n2, and the second capacitor 151b receives the inverted clock signal, the first transistor 151c The first node n1 is electrically connected to the first node n1. The gate of the first transistor 151c is electrically connected to the second node n2. The source of the first transistor 151c is electrically connected to the third node n3. The source of the transistor 151d is electrically connected to the third node n3. The gate of the second transistor 151d is electrically connected to the second node n2. The second transistor 151d is electrically connected to the fourth node n4. The third transistor 151e is electrically connected to the first node n1, and the gate of the third transistor 151e is electrically connected to the third node n3. The source of the third transistor 151e is electrically connected to the second node. N2, the source of the fourth transistor 151f is electrically connected to the second node n2, the fourth transistor The gate of the body 151f is electrically connected to the third node n3, and the fourth transistor 151f is electrically connected to the fourth node n4. The DC voltage Vcp_in passes through each of the boosting elements 151. After the voltage component 150, the DC voltage Vcp_in is superimposed with the voltage of a clock signal clk. Preferably, the voltage of the clock signal clk is set to be the same as the DC voltage Vcp_in (2.5 V). After the DC voltage Vcp_in passes through the five boosting elements 151, the voltage is boosted to 15V (2.5 V+2.5 V*5), thereby providing the boosting voltage Vcp_out having a voltage greater than 14.7 V for use by each of the stimulation waveform generators 140.

Referring to FIGS. 1 and 5, each of the stimulation waveform generators 140 has an operational amplifier 141 and an analog switch 142. Each of the operational amplifiers 141 is electrically connected to each of the sampling elements 132 to receive each of the voltage signals SH_out. The operational amplifier 141 outputs an amplified voltage signal HV_out. In the embodiment, each of the operational amplifiers 141 is electrically connected to the boosting circuit 150, and the boosting voltage Vcp_out of the boosting circuit 150 is used as the operational amplifier 141. The power source amplifies each of the voltage signals SH_out, and each of the analog switches 142 is electrically connected to each of the operational amplifiers 141 and the control circuit 110 to receive the amplified voltage signals HV_out and the stimulation type signals STS, and the analog switches 142 output A stimulating electric wave o_sti, wherein each of the amplified voltage signals HV_out is used to determine the amplitude of the stimulating electric wave o_sti, and the stimulation type signal STS is used to determine the frequency, polarity and pulse width of the stimulating electric wave o_sti.

Referring to FIG. 6, the operational amplifier 141 has a low voltage terminal LV and a high voltage terminal HV. The low voltage terminal LV has a bias circuit 141a and an input stage circuit 141b. The input stage circuit 141b is electrically connected to the bias voltage. The circuit 141a, and the bias circuit 141a and the input stage circuit 141b receive the voltage source VDD of 2.5 V. The high voltage terminal HV has an output stage circuit 141c, and the output stage circuit 141c is electrically connected to the input stage circuit. 141b, and the output stage circuit 141c uses the boosted voltage Vcp_out (voltage greater than 14.7 V) as a voltage source, and outputs each of the amplified voltage signals HV_out.

Referring to FIG. 7, each of the analog switches 142 uses the amplified voltage signal HV_out of each of the operational amplifiers 141 as a voltage source, and each of the analog switches 142 has a first end 143 and a second end 144. The first end 143 is electrically connected to the first end 143 and the second end 144. The first end 143 has a first low voltage switch 143a, a first voltage dividing resistor group 143b, a first high voltage switch 143c and a first a grounding switch 143d, each of the first low-voltage switch 143a is electrically connected to the control circuit 110, the first voltage-dividing resistor group 143b is electrically connected between the first low-voltage switch 143a and each of the operational amplifiers 141, the first The high voltage switch 143c is electrically connected to the first voltage dividing resistor group 143b, the operational amplifier 141 and the first grounding switch 143d. Each of the first grounding switches 143d is electrically connected to the control circuit 110. The second terminal 144 has a second low voltage switch 144a, a second voltage dividing resistor group 144b, a second high voltage switch 144c and a second grounding switch 144d, each of the second low voltage switch 144a is electrically connected to the control circuit 110, the second voltage dividing The resistor group 144b is electrically connected to the second low voltage switch Between the 144a and each of the operational amplifiers 141, the second high voltage switch 144c is electrically connected to the second voltage dividing resistor group 144b, the operational amplifier 141 and each of the second grounding switches 144d, and each of the second grounding switches 144d is electrically connected. The control circuit 110 is connected sexually.

Referring to FIGS. 1 and 7, in the embodiment, the control circuit 110 transmits 16 sets of the stimulation type signal STS to each of the analog circuits 142, and each of the stimulation type signals STS has a first type signal STS1 and a The second type of signal STS2, the first low voltage switch 143a of the first end 143 and the second grounding switch 144d of the second end 144 receive the first type signal STS1, and the first type signal STS In order to determine that each of the first low voltage switch 143a and each of the second grounding switches 144d is turned on or off, each of the first low voltage switch 143a and each of the second grounding switches 144d are simultaneously turned on or off, and each of the first low voltage switches 143a The first voltage dividing resistor group 143b receives each of the amplified voltage signals HV_out, and each of the first voltage dividing resistor groups 143b has a first resistor 143e and a second resistor 143f, each of the first resistors 143e and each The second resistor 143f divides each of the amplified voltage signals HV_out to turn on the first high voltage switch 143c. Therefore, when the first low voltage switch 143a is turned on, the first high voltage switch 143c and the second ground switch 144d Also conductive and The first electrode 160 forms a loop to stimulate each of the L1 wave generating o_sti, and by controlling each STS1 signal of the first type, each of the adjusted stimulation o_sti radio frequency and pulse width.

Referring to FIG. 7, the second low-voltage switch 144a of the second end 144 and the first grounding switch 143d of the first end 143 receive the second type signal STS2, and the second type signal STS2 is used. In order to determine that each of the second low voltage switch 144a and each of the first grounding switches 143d is turned on or off, each of the second low voltage switch 144a and each of the first grounding switches 143d are simultaneously turned on or off, and each of the second low voltage switches 144a The second voltage dividing resistor group 144b receives each of the amplified voltage signals HV_out, and each of the second voltage dividing resistor groups 144b has a third resistor 144e and a fourth resistor 144f, each of the third resistors 144e and Each of the fourth resistors 144f divides each of the amplified voltage signals HV_out to turn on the second high voltage switches 144c. Therefore, when the second low voltage switches 144a are turned on, the second high voltage switch 144c and the first ground. The switch 143d is also turned on to form a second loop L2 with each of the electrodes 160 to generate each of the stimulating waves o_sti, and the frequency and pulse width of each of the stimulating waves o_sti can be adjusted by the control of each of the second type signals STS2. . The first loop L1 or the second loop L2 can be turned on or off by the first type signal STS1 and the second type signal STS2 of the stimulus type signal STS, thereby outputting each of the stimulation waves o_sti The electrode 160 is electrically stimulated, and because the current directions of the first loop and the second loop are different, the polarity of each of the stimulation waves o_sti can be changed, and the amplitude of each of the stimulation waves o_sti and each of the amplifications The voltage signals HV_out are the same. Therefore, the amplitude of each of the stimulation waves o_sti can be adjusted by each of the amplified voltage signals HV_out, and the frequency of each of the stimulation waves o_sti and the pulse width can be adjusted by each of the stimulation type signals STS. In order to make the multi-channel spinal cord electrical stimulation generator 100 more widely applicable, it can be applied to different types of electrical stimulation treatment.

The multi-channel spinal cord electrical stimulation generator 100 outputs a plurality of the stimulation waves o_sti of adjustable amplitude, frequency, polarity and pulse width to perform different types of electrical stimulation therapy, and is integrated by the various components of the present invention. In an integrated circuit, the volume of the multi-channel spinal cord electrical stimulation generator 100 is reduced, and the power consumption of the multi-channel spinal cord electrical stimulation generator 100 can be reduced to reduce the user's use of the implantable device. Discomfort.

The scope of the present invention is defined by the scope of the appended claims, and any changes and modifications made by those skilled in the art without departing from the spirit and scope of the invention are within the scope of the present invention. .

100. . . Multi-channel spinal cord stimulation generator

110. . . Control circuit

120. . . Digital analog conversion circuit

121. . . Current switch group

121a. . . Battery

121b. . . Current switch

122. . . buffer

123. . . Grounding resistance

130. . . Sampling circuit

131. . . Multiplexer

132. . . Sampling component

132a. . . Voltage switch

132b. . . capacitance

132c. . . Gain buffer

132d. . . inverter

132e. . . Redundant switch

132f. . . Reset switch

140. . . Stimulus waveform generator

141. . . Operational Amplifier

141a. . . Bias circuit

141b. . . Input stage circuit

141c. . . Output stage circuit

142. . . Analog switch

143. . . First end

143a. . . First low voltage switch

143b. . . First voltage dividing resistor group

143c. . . First high voltage switch

143d. . . First grounding switch

143e. . . First resistance

143f. . . Second resistance

144. . . Second end

144a. . . Second low voltage switch

144b. . . Second voltage dividing resistor

144c. . . Second high voltage switch

144d. . . Second grounding switch

144e. . . Third resistance

144f. . . Fourth resistor

150. . . Boost circuit

151. . . Boost element

151a. . . First capacitor

151b. . . Second capacitor

151c. . . First transistor

151d. . . Second transistor

151e. . . Third transistor

151f. . . Fourth transistor

152. . . inverter

160. . . electrode

200. . . Electrical stimulation generator

210. . . Power supply unit

220. . . Voltage conversion unit

230. . . control unit

240. . . Protective component

250. . . Energy storage component

260. . . Current direction control switch

270. . . Output coil

ACS. . . Amplitude control signal

CSS. . . Channel selection signal

STS. . . Stimulus type signal

STS1. . . First type signal

STS2. . . Second type signal

DAC_out. . . Amplitude signal

SS. . . Select signal

SH_out. . . Voltage signal

HV_out. . . Amplified voltage signal

O_sti. . . Shock wave

Vcp_in. . . DC voltage

Clk. . . Clock signal

Vcp_out. . . Boost voltage

L1. . . First loop

L2. . . Second loop

Dac_vbias. . . DC bias

VDD. . . power source

N1. . . First node

N2. . . Second node

N3. . . Third node

N4. . . Fourth node

Rst. . . Reset signal

LV. . . Low pressure end

HV. . . High pressure end

1 is a block diagram of a multi-channel spinal cord electrical stimulation generator in accordance with an embodiment of the present invention. 2 is a circuit diagram of a digital analog conversion circuit in accordance with an embodiment of the present invention. Figure 3 is a circuit diagram of a sampling circuit in accordance with an embodiment of the present invention. Figure 4 is a circuit diagram of a booster circuit in accordance with an embodiment of the present invention. Figure 5 is a circuit diagram of a stimulus waveform generator in accordance with an embodiment of the present invention. Figure 6 is a circuit diagram of an operational amplifier of one of the stimulation waveform generators in accordance with an embodiment of the present invention. Figure 7 is a circuit diagram of an analog switch of one of the stimulation waveform generators in accordance with an embodiment of the present invention. Figure 8: A block diagram of a conventional electrical stimulation generator.

100. . . Multi-channel spinal cord stimulation generator

110. . . Control circuit

120. . . Digital analog conversion circuit

130. . . Sampling circuit

140. . . Stimulus waveform generator

150. . . Boost circuit

160. . . electrode

ACS. . . Amplitude control signal

CSS. . . Channel selection signal

STS. . . Stimulus type signal

DAC_out. . . Amplitude signal

SH_out. . . Voltage signal

Vcp_in. . . DC voltage

Clk. . . Clock signal

Vcp_out. . . Boost voltage

Dac_vbias. . . DC bias

Rst. . . Reset signal

Claims (11)

A multi-channel spinal cord electrical stimulation generator includes: a control circuit that outputs an amplitude control signal, a channel selection signal, and a plurality of stimulation type signals; and a digital analog conversion circuit electrically connected to the control circuit to receive The amplitude control signal, and the digital analog conversion circuit outputs an amplitude signal, wherein the amplitude control signal is used to determine the magnitude of the amplitude signal; a sampling circuit having a multiplexer and a plurality of sampling components, the multiplexer Electrically connecting the control circuit to receive the channel selection signal, and the multiplexer outputs a plurality of selection signals, each of the sampling elements being electrically connected to the digital analog conversion circuit and the multiplexer to receive the amplitude signal and each of the Selecting a signal, and each of the sampling elements outputs a voltage signal, wherein each of the selection signals is used to determine whether each of the sampling elements is turned on or off, the amplitude signal is used to determine the magnitude of the voltage signals; and a plurality of stimulation waveform generators Each of the stimulation waveform generators has an operational amplifier and an analog switch, each of which The amplifier is electrically connected to each of the sampling elements to receive the voltage signals, and each of the operational amplifiers outputs an amplified voltage signal, and each of the analog switches is electrically connected to each of the operational amplifiers and the control circuit to receive the amplified voltage signals. And the stimulation type signal, and each of the analog switches outputs a stimulation wave, wherein each of the amplified voltage signals is used to determine the size of each of the stimulation waves, and each of the stimulation type signals is used to determine the frequency of each of the stimulation waves. The multi-channel spinal cord electrical stimulation generator according to claim 1, further comprising a boosting circuit electrically connected to each of the stimulation waveform generators, the boosting circuit receiving the DC voltage, And the boost circuit provides a boost voltage to each of the stimulation waveform generators. The multi-channel spinal cord electrical stimulation generator according to claim 1, wherein the digital analog conversion circuit is an 8-bit current-steering DAC. The multi-channel spinal cord electrical stimulation generator according to claim 3, wherein the digital analog conversion circuit has a plurality of current switch groups, a buffer and a grounding resistor, each of the current switch groups having a current source and a current switch, each of the current switches is electrically connected between each of the current sources and the buffer, so that the current source and the buffer are turned on or off, and the grounding resistor is electrically connected to the current switches. And the buffer. The multi-channel spinal cord electrical stimulation generator according to claim 4, wherein each of the current switches of the digital analog conversion circuit is a P-type transistor, and each of the current switches is electrically connected to the control circuit and receives the The amplitude control signal is used to determine whether each of the current switches is turned on or off. The multi-channel spinal cord electrical stimulation generator according to claim 1, wherein each sampling element of the sampling circuit has a voltage switch, a capacitor and a gain buffer, and each of the voltage switches is electrically connected to the Between the digital analog conversion circuit and each of the gain buffers, the digital analog conversion circuit and each of the gain buffers are turned on or off, and the capacitors are coupled to the digital analog conversion circuit to store the amplitude signal. . The multi-channel spinal cord electrical stimulation generator according to claim 6, wherein the multiplexer is a 4-to-16 decoder. The multi-channel spinal cord electrical stimulation generator according to claim 6, wherein each of the sampling elements further has an inverter and a redundant switch, and each of the inverters is electrically connected to the multiplexer and Between each of the redundant switches, the inverter receives each of the selection signals of the multiplexer and provides an inverted selection signal to the redundant switch, and the redundant switch is electrically connected to each of the voltage switches. The multi-channel spinal cord electrical stimulation generator according to claim 6, wherein each of the sampling elements further has a reset switch, and each of the reset switch gate terminals receives a reset signal, and each of the reset switches Then, the capacitors are electrically connected to each other, and the source terminals of the reset switches are grounded. When the reset signals received by the reset switches are high, the reset switches are turned on, so that each This capacitor discharges to a low potential. The multi-channel spinal cord electrical stimulation generator according to claim 1, wherein each of the analog switches has a first end and a second end, the first end having a first low voltage switch and a first minute a first resistor switch group, a first high voltage switch and a first ground switch, wherein the first low voltage switch is electrically connected to the control circuit, and the first voltage dividing resistor group is electrically connected to the first low voltage switch and the operational amplifier The first high voltage switch is electrically connected to the first voltage dividing resistor group, each of the operational amplifiers and each of the first grounding switches, and each of the first grounding switches is electrically connected to the control circuit, and the second end has a first a second low voltage switch, a second voltage dividing resistor group, a second high voltage switch and a second grounding switch, wherein the second low voltage switch is electrically connected to the control circuit, and the second voltage dividing resistor group is electrically connected to the first The second high voltage switch is electrically connected to the second voltage dividing resistor group, each of the operational amplifiers and each of the second grounding switches, and the second grounding switch is electrically connected to the control circuit. . The multi-channel spinal cord electrical stimulation generator of claim 10, wherein each of the stimulation type signals of the control circuit has a first type of signal and a second type of signal, each of the first end a first type of signal is received by the low voltage switch and the second grounding switch of the second end, and each of the first type of signals is used to determine whether each of the first low voltage switch and each of the second grounding switches is turned on or off. When the first low voltage switch is turned on, each of the first high voltage switch and each of the second grounding switches is also turned on to form a first loop, and the second low voltage switch of each of the second ends and the first end of the first end a grounding switch receives the second type of signal, each of the second type of signals is used to determine whether each of the second low voltage switch and each of the first grounding switches is turned on or off. When each of the second low voltage switches is turned on, each of the second The high voltage switch and each of the first grounding switches are also turned on to form a second loop.