TWI498105B - Independent tumor detection module - Google Patents
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Description
本發明係關於一種腫瘤偵測模組,特別關於一種外接式腫瘤偵測模組。The invention relates to a tumor detecting module, in particular to an external tumor detecting module.
現有的腫瘤偵測方法,一是經由自行觸診,但觸診的精確度並不高;另一是到大醫院藉由超音波、MRI…等等大型設備進行檢查,但此法需要許多技術人員,無法自行完成,也無法在很短時間內得到檢查的結果。而且大部分民眾沒有定期到醫院檢測的習慣,故無法達到提早發現的效果。The existing methods of tumor detection are based on self-diagnosis, but the accuracy of palpation is not high. The other is to go to large hospitals for inspection by large equipment such as ultrasound, MRI, etc., but this method requires many techniques. The personnel cannot complete the results themselves, nor can they get the results of the inspection in a short time. Moreover, most people do not have the habit of regularly going to the hospital for testing, so it is impossible to achieve the effect of early detection.
因此,如何提供一種外接式腫瘤偵測模組,能夠方便讓使用者自行檢測以達到預防或提早發現之效果,實為當前重要課題之一。Therefore, how to provide an external tumor detection module can facilitate the user to self-detect to achieve the effect of prevention or early detection, which is one of the current important topics.
有鑑於上述課題,本發明之目的為提供一種能夠方便讓使用者自行檢測之外接式腫瘤偵測模組。In view of the above problems, an object of the present invention is to provide an external tumor detecting module that can be easily detected by a user.
為達上述目的,依據本發明之一種外接式腫瘤偵測模組用以偵測一組織是否具有腫瘤,並與一電子裝置配合使用,其係包含複數發光元件、至少一光感測元件、一訊號傳輸單元以及一處理單元。該等發光元件輪流發出一光線經由該組織繞射。光感測元件鄰設於該等發光元件,吸收該等繞射光線並對應產生複數感測訊號。訊號傳輸單元係將該等感測訊號傳送至電子裝置,使電子裝置可依據該等感測訊號而決定該組織是否具有腫瘤。處理單元係與該等發光元件、光感測元件及訊號傳輸單元電性連接。In order to achieve the above object, an external tumor detecting module according to the present invention is configured to detect whether a tissue has a tumor, and is used in combination with an electronic device, which comprises a plurality of light emitting elements, at least one light sensing element, and a A signal transmission unit and a processing unit. The illuminating elements alternately emit a light that is diffracted through the tissue. The light sensing elements are disposed adjacent to the light emitting elements, absorbing the diffracted rays and correspondingly generating a plurality of sensing signals. The signal transmission unit transmits the sensing signals to the electronic device, so that the electronic device can determine whether the tissue has a tumor according to the sensing signals. The processing unit is electrically connected to the light emitting elements, the light sensing elements, and the signal transmission unit.
在本發明之一實施例中,外接式腫瘤偵測模組更包含一處理程式,其係依據該等感測訊號而決定該組織是否具有腫瘤,處理程式可儲存於一光碟、一記憶體或一伺服器。In an embodiment of the present invention, the external tumor detection module further includes a processing program for determining whether the tissue has a tumor according to the sensing signals, and the processing program can be stored on a CD, a memory or A server.
在本發明之一實施例中,其中任兩發光元件係相距x公分之水平距離,該光感測元件與其中一發光元件相距一y公分之水平距離,其中x與y滿足x0.1*y之關係式。此外,當外接式腫瘤偵測模組具有複數光感測元件時,該等光感測元件鄰設於該等發光元件並使該等發光元件實質位於該等光感測元件之中心,該等光感測元件分別吸收該等繞射光線而對應產生該等感測訊號。In an embodiment of the invention, any two of the light-emitting elements are separated by a horizontal distance of x centimeters, and the light-sensing element is separated from one of the light-emitting elements by a horizontal distance of one ym, wherein x and y satisfy x. The relationship of 0.1*y. In addition, when the external tumor detecting module has a plurality of light sensing elements, the light sensing elements are disposed adjacent to the light emitting elements and the light emitting elements are substantially located at the center of the light sensing elements. The light sensing elements respectively absorb the diffracted rays to generate the sensing signals.
在本發明之一實施例中,該等發光元件所發射之波長係分別對應去氧血紅素、總血量、含氧血紅素、水、脂肪之至少其中之二的參數。另外,該等發光元件之其中之一所發出之光線係作為膚色校正。In an embodiment of the invention, the wavelengths emitted by the light-emitting elements correspond to parameters of at least two of deoxyhemoglobin, total blood volume, oxygenated hemoglobin, water, and fat, respectively. In addition, the light emitted by one of the light-emitting elements is corrected as a skin tone.
承上所述,本發明揭露一種外接式的腫瘤偵測模組,這裡的外接式係指例如藉由連接器而與一電子裝置連結、或與一電子裝置進行無線通訊。藉此,使用者若需要不定期偵測身體組織是否正常,可購買外接式腫瘤偵測模組,並與一電子裝置,例如手機或PDA連結,即可進行偵測,或是購買外接式腫瘤偵測模組,其可與電子裝置進行無線通訊,例如藉由藍芽技術,可將偵測結果傳送至電子裝置進行處理,以得到偵測結果。藉此,本發明之外接式腫瘤偵測模組有助於使用者自行檢測以達到預防或提早發現之效果,且非常方便使用,這大大提高使用者自行檢測的意願。In view of the above, the present invention discloses an external tumor detection module, wherein the external connection refers to connection with an electronic device or wireless communication with an electronic device, for example, by a connector. In this way, if the user needs to detect the normality of the body tissue from time to time, the user can purchase an external tumor detection module and connect with an electronic device such as a mobile phone or a PDA to detect or purchase an external tumor. The detection module can communicate wirelessly with the electronic device. For example, through the Bluetooth technology, the detection result can be transmitted to the electronic device for processing to obtain the detection result. Therefore, the external tumor detection module of the invention can help the user to detect by itself to achieve the effect of prevention or early detection, and is very convenient to use, which greatly improves the user's willingness to detect by himself.
此外,發光元件輪流發出一光線(例如近紅外線)經由組織繞射,再被光感測元件吸收而產生感測訊號,由於病變組織與正常組織之含氧血基血溶素及去氧血基血溶素之比例不同,故當光線經過正常組織與病變組織時,兩者對光線吸收的程度亦不同,使得近紅外線光譜經由組織繞射而收回之訊號強度有所差異。如此,藉由處理單元之處理即可判斷組織是否具有腫瘤或癌細胞等病變組織。In addition, the illuminating element emits a light (for example, near-infrared rays) in turn through the tissue, and is absorbed by the light sensing element to generate a sensing signal, due to the oxygenated blood-based blood lysin and deoxygenated blood base of the diseased tissue and the normal tissue. The ratio of blood lysin is different, so when the light passes through the normal tissue and the diseased tissue, the degree of light absorption is different, so that the signal intensity of the near-infrared spectrum recovered by the tissue diffraction is different. In this way, it is possible to determine whether the tissue has a diseased tissue such as a tumor or a cancer cell by the processing of the processing unit.
此外,本發明藉由x與y滿足x0.1*y之關係式,而限制各發光元件與光感測元件之水平距離實質相同,使得光感測元件係在相同的基準線接收來自各發光元件所發出之光線,進而簡化分析,並可降低處理程式之成本。Furthermore, the present invention satisfies x by x and y a relationship of 0.1*y, and limiting the horizontal distance between each of the light-emitting elements and the light-sensing element is substantially the same, so that the light-sensing elements receive light from the respective light-emitting elements on the same reference line, thereby simplifying analysis and Reduce the cost of the processing program.
此外,其中一發光元件所發出之光線係作為膚色校正,可提高腫瘤判斷之準確度。In addition, the light emitted by one of the light-emitting elements is corrected as a skin color, which improves the accuracy of tumor determination.
此外,複數光感測元件設置於該等發光元件之中心範圍,該等光感測元件之感測訊號可進一步作為腫瘤判斷之依據而提高準確度,且該等光感測元件設置於該等發光元件之中心範圍亦簡化訊號處理過程。In addition, the plurality of light sensing elements are disposed at a central range of the light emitting elements, and the sensing signals of the light sensing elements can further improve the accuracy as a basis for determining the tumor, and the light sensing elements are disposed on the light sensing elements. The central range of the illuminating elements also simplifies the signal processing.
以下將參照相關圖式,說明依本發明較佳實施例之一種外接式腫瘤偵測模組,其中相同的元件將以相同的參照符號加以說明。An external tumor detecting module according to a preferred embodiment of the present invention will be described with reference to the accompanying drawings, wherein like elements will be described with the same reference numerals.
圖1為本發明較佳實施例之一種外接式腫瘤偵測模組1的外觀示意圖,圖2為外接式腫瘤偵測模組1的方塊示意圖,圖3為外接式腫瘤偵測模組1與一電子裝置E配合使用的示意圖。外接式腫瘤偵測模組1包含一處理單元11、複數發光元件12、一光感測元件13以及一訊號傳輸單元14。外接式腫瘤偵測模組1係用以讓使用者握持並靠近身體組織以進行病變組織(例如腫瘤或癌症)之偵測。本實施例所指之腫瘤係泛指一般病變組織,例如一般腫瘤或癌症等。1 is a schematic diagram of an external tumor detecting module 1 according to a preferred embodiment of the present invention, FIG. 2 is a block diagram of an external tumor detecting module 1, and FIG. 3 is an external tumor detecting module 1 and A schematic diagram of an electronic device E used in conjunction. The external tumor detection module 1 includes a processing unit 11, a plurality of light-emitting elements 12, a light sensing element 13, and a signal transmission unit 14. The external tumor detection module 1 is used to allow the user to hold and approach the body tissue for detection of diseased tissues such as tumors or cancer. The tumor system referred to in this embodiment generally refers to a general diseased tissue, such as a general tumor or cancer.
外接式腫瘤偵測模組1可製成為任何方便使用者使用或握持的形狀,於此外接式腫瘤偵測模組1係製成為類似USB硬碟的形狀。The external tumor detecting module 1 can be made into any shape that is convenient for the user to use or hold, and the external tumor detecting module 1 is made into a shape similar to a USB hard disk.
該等發光元件12設置於載體11,並輪流發出一光線經由該組織繞射(可包含散射)。本實施例之發光元件12係以發光二極體(LED)為例。發光元件12之數量只要大於2皆可,於此係以6顆LED為例。發光元件12係輪流發出一光線,於此並無特定之發光順序,可例如以排序為其發光順序。當使用者握持外接式腫瘤偵測模組1進行偵測時,發光元件12所發出之光線係經由人體組織(例如乳房)繞射。The light-emitting elements 12 are disposed on the carrier 11 and alternately emit a light that is diffracted through the tissue (which may include scattering). The light-emitting element 12 of the present embodiment is exemplified by a light-emitting diode (LED). The number of the light-emitting elements 12 may be greater than two, and six LEDs are taken as an example. The illuminating elements 12 emit a ray of light in turn, and there is no specific order of illumination, which can be ordered, for example, in order of illumination. When the user holds the external tumor detecting module 1 for detection, the light emitted by the light-emitting element 12 is diffracted through human tissue (for example, a breast).
各發光元件12係發出不同波長之光線,於此,各發光元件12所發出之光線波長分別為690nm、760nm、805nm、850nm、910nm、970nm,其中690nm係用以膚色校正,760nm係對應去氧血紅素、805nm係對應去氧血紅素與含氧血紅素於光譜上之交點並可表徵總血量,850nm係對應含氧血紅素、910nm係對應水、970nm係對應脂肪。另外,為提升訊號判讀之能力,外接式腫瘤偵測模組1可更包含一濾光片15,設置於該等發光元件12之光路徑上,使光線經由濾光片15再到達光感測元件13。本實施例之濾光片15可將650nm以下之光線排除以消除可見光之干擾。Each of the light-emitting elements 12 emits light of different wavelengths. Here, the light-emitting elements 12 emit light having wavelengths of 690 nm, 760 nm, 805 nm, 850 nm, 910 nm, and 970 nm, respectively, wherein 690 nm is used for skin color correction, and 760 nm is deoxygenated. The heme and 805 nm correspond to the spectral intersection of deoxyhemoglobin and oxygenated hemoglobin and can express the total blood volume. The 850 nm system corresponds to the oxygenated hemoglobin, the 910 nm-based corresponding water, and the 970 nm-based corresponding fat. In addition, in order to improve the ability of the signal interpretation, the external tumor detection module 1 further includes a filter 15 disposed on the light path of the light-emitting elements 12 to allow light to pass through the filter 15 to reach the light sensing. Element 13. The filter 15 of this embodiment can exclude light below 650 nm to eliminate interference of visible light.
光感測元件13鄰設於該等發光元件12,吸收該等繞射光線並對應產生複數感測訊號。光感測元件13可例如為光電二極體或電荷耦合元件(CCD)等等可將光線轉換為電訊號之元件。The light sensing elements 13 are disposed adjacent to the light emitting elements 12, absorbing the diffracted rays and correspondingly generating a plurality of sensing signals. The light sensing element 13 can be, for example, a photodiode or a charge coupled device (CCD) or the like that converts light into an electrical signal.
訊號傳輸單元14係將該等感測訊號傳送至電子裝置E,使電子裝置E可依據該等感測訊號而決定該組織是否具有腫瘤。於此,電子裝置E係以手機為例。訊號傳輸單元14可為無線傳送單元或有線傳送單元,於此係以有線傳送單元為例,且傳輸介面為USB傳輸介面。訊號傳輸單元14包含一連接器(USB connector),連接器外露於外接式腫瘤偵測模組1。另請參照圖4所示,其係顯示訊號傳輸單元為無線傳送單元,並與電子裝置E進行無線通訊,例如藍芽通訊。The signal transmission unit 14 transmits the sensing signals to the electronic device E, so that the electronic device E can determine whether the tissue has a tumor according to the sensing signals. Here, the electronic device E is exemplified by a mobile phone. The signal transmission unit 14 can be a wireless transmission unit or a wired transmission unit. The wired transmission unit is taken as an example, and the transmission interface is a USB transmission interface. The signal transmission unit 14 includes a connector (USB connector), and the connector is exposed to the external tumor detecting module 1. Please refer to FIG. 4, which shows that the signal transmission unit is a wireless transmission unit and performs wireless communication with the electronic device E, such as Bluetooth communication.
處理單元11係與該等發光元件12、光感測元件13及訊號傳輸單元14電性連接,並可驅動該等元件作動。於此,處理單元11包含一電路板及電路板上之電子元件及電路,例如處理器(processor)、控制器(controller)。另外,處理單元11係可接收並處理感測訊號,於此,處理單元11可包含一數位/類比轉換電路(Digital to analog converter,DAC),可將光感測元件13所產生之數位感測訊號轉換成類比感測訊號。另外,處理單元11可依需要而具有例如濾波電路、比較電路等,於此,處理單元11具有低通濾波電路(low pass filter,LPF)以將高頻雜訊濾除。需注意的是,處理單元11有一些功能亦可移至電子裝置E執行,例如數位/類比轉換電路可移至電子裝置E。The processing unit 11 is electrically connected to the light-emitting elements 12, the light-sensing elements 13, and the signal transmission unit 14, and can be driven to operate. Here, the processing unit 11 includes a circuit board and electronic components and circuits on the circuit board, such as a processor and a controller. In addition, the processing unit 11 can receive and process the sensing signal. Here, the processing unit 11 can include a digital to analog converter (DAC), which can sense the digital position generated by the light sensing component 13. The signal is converted into an analog sensing signal. In addition, the processing unit 11 may have, for example, a filter circuit, a comparison circuit, and the like as needed. Here, the processing unit 11 has a low pass filter (LPF) to filter high frequency noise. It should be noted that some functions of the processing unit 11 may also be moved to the electronic device E for execution, for example, the digital/analog conversion circuit may be moved to the electronic device E.
外接式腫瘤偵測模組1更包含一殼體18,其係容置該等發光元件12、光感測元件13、訊號傳輸單元14及處理單元11。另外,外接式腫瘤偵測模組1可更包含一供電單元16及至少一控制鈕17,供電單元16及控制鈕17係與處理單元11電性連接,供電單元16例如包含電池或充電電路,而控制鈕17可作為供電單元16之開關。另外,控制鈕17亦可作為其他功能之用,例如操作模式之選擇,或者,外接式腫瘤偵測模組1可包含其他控制鈕來作為其他功能之用。The external tumor detecting module 1 further includes a housing 18 for accommodating the light emitting elements 12, the light sensing elements 13, the signal transmitting unit 14, and the processing unit 11. In addition, the external tumor detecting module 1 further includes a power supply unit 16 and at least one control button 17, and the power supply unit 16 and the control button 17 are electrically connected to the processing unit 11, and the power supply unit 16 includes, for example, a battery or a charging circuit. The control button 17 can be used as a switch for the power supply unit 16. In addition, the control button 17 can also be used for other functions, such as selection of an operation mode, or the external tumor detection module 1 can include other control buttons for other functions.
圖5為外接式腫瘤偵測模組1的俯視放大示意圖。如圖5所示,任兩發光元件之中心點(圖5係以上面算來第2顆及第3顆為例)係相距x公分之水平距離,而光感測元件13係與其中一發光元件(不限制哪一顆,於此係以第4顆為例)相距一y公分之水平距離,其中x與y滿足x0.1*y之關係式,藉此可限制各發光元件12與光感測元件13之水平距離實質相同,使得光感測元件13係在相同的基準線接收來自各發光元件12所發出之光線,進而簡化分析。在本實施例中,發光元件12係排成一行,並位於光感測元件13之一側。需補充說明,x可能是製造誤差所造成、或是刻意迴避設計所造成,而後者應被視為與本發明之概念相同。另外,x越大則產生訊號之分析難度越高,但x仍有一合理範圍。FIG. 5 is an enlarged schematic plan view of the external tumor detecting module 1. As shown in FIG. 5, the center point of any two light-emitting elements (Fig. 5 is based on the second and third figures above) is a horizontal distance of x cm, and the light sensing element 13 is illuminated with one of them. The component (not limited to which one, for example, the fourth one) is a horizontal distance of one ycm, where x and y satisfy x. a relationship of 0.1*y, whereby the horizontal distance between each of the light-emitting elements 12 and the light-sensing element 13 can be substantially the same, so that the light-sensing elements 13 receive the light emitted from the respective light-emitting elements 12 at the same reference line. This simplifies the analysis. In the present embodiment, the light-emitting elements 12 are arranged in a line and are located on one side of the light sensing element 13. It should be added that x may be caused by manufacturing errors or deliberately avoiding design, and the latter should be considered to be the same as the concept of the present invention. In addition, the larger x is, the more difficult it is to analyze the signal, but x still has a reasonable range.
在繼續說明外接式腫瘤偵測模組1之操作之前,需先說明光線在組織內繞射(包含散射)的情況。請參照圖6及圖7所示,其係顯示發光元件12發射光線,光線經由組織內繞射,並穿出而由光感測元件接收,其中圖6之組織係正常組織,圖7之組織係具有病變組織T,由圖7可知,繞射光線之一部分會由病變組織T吸收,使得光感測元件13所接收到之光線強度減弱。Before continuing to explain the operation of the external tumor detection module 1, it is necessary to explain the diffraction of light (including scattering) in the tissue. Referring to FIG. 6 and FIG. 7 , it is shown that the light-emitting element 12 emits light, the light is diffracted through the tissue, and is received by the light-sensing element, wherein the tissue of FIG. 6 is a normal tissue, and the organization of FIG. 7 It has a diseased tissue T. As can be seen from Fig. 7, a part of the diffracted light is absorbed by the diseased tissue T, so that the intensity of the light received by the light sensing element 13 is weakened.
圖8係使用者握持外接式腫瘤偵測模組1進行偵測的操作示意圖,其中使用者係沿一水平方向進行掃描偵測,例如左胸至右胸。在偵測時,發光元件12係輪流發射不同波長之光線,並經由組織繞射而由光感測元件13吸收並對應產生複數感測訊號。需注意者,圖8係以無線傳輸為例,故使用者僅需握持外接式腫瘤偵測模組1進行偵測,若係以有線傳輸為例,則使用者需先連接外接式腫瘤偵測模組1與電子裝置E(即以圖3之態樣)再進行掃描。FIG. 8 is a schematic diagram of the operation of the user holding the external tumor detecting module 1 for detecting, wherein the user performs scanning detection in a horizontal direction, for example, a left chest to a right chest. During detection, the illuminating element 12 emits light of different wavelengths in turn, and is absorbed by the light sensing element 13 via tissue diffraction and correspondingly generates a plurality of sensing signals. It should be noted that in Figure 8, the wireless transmission is taken as an example. Therefore, the user only needs to hold the external tumor detection module 1 for detection. If wired transmission is taken as an example, the user needs to connect the external tumor detection first. The test module 1 and the electronic device E (ie, in the aspect of FIG. 3) are scanned again.
訊號傳輸單元14係將感測訊號傳送至電子裝置E以進行分析處理。電子裝置E所處理之感測訊號的波形可參照圖9所示,其中X軸單位係毫秒(ms),Y軸單位係電壓(voltage),且圖9係以病變組織為例。由圖9可知,當外接式腫瘤偵測模組1沿著如圖8所示之方向掃描,且一開始掃描到正常組織時,訊號係沒有特別的改變(0ms至800ms),而當掃描到病變組織時,訊號強度係顯著的下降(900ms至1350ms),此因部分光線被病變組織吸收,然後當再次掃描到正常組織時,訊號強度又回到正常值(1800ms至2500ms)。藉此,電子裝置E可依據該等感測訊號而決定組織是否具有腫瘤。The signal transmission unit 14 transmits the sensing signal to the electronic device E for analysis processing. The waveform of the sensing signal processed by the electronic device E can be referred to FIG. 9, wherein the X-axis unit is millisecond (ms), the Y-axis unit is voltage, and FIG. 9 is based on a diseased tissue. As can be seen from FIG. 9, when the external tumor detecting module 1 scans in the direction as shown in FIG. 8, and the scanning starts to normal tissue, the signal system has no special change (0ms to 800ms), and when scanning In diseased tissue, the signal intensity decreased significantly (900ms to 1350ms), because some of the light was absorbed by the diseased tissue, and then when it was scanned again to normal tissue, the signal intensity returned to normal (1800ms to 2500ms). Thereby, the electronic device E can determine whether the tissue has a tumor according to the sensing signals.
在其他實施例中,外接式腫瘤偵測模組1可更包含一處理程式,其可依據該等感測訊號而決定該組織是否具有腫瘤,即處理程式係接收該等感測訊號而輸出是否具有腫瘤之結果。其中,處理程式可儲存於一光碟、一記憶體或一伺服器。當使用者在購買外接式腫瘤偵測模組1,可附送一光碟、USB硬碟、或給予一密碼使其上網自伺服器下載處理程式。另外,處理程式亦可儲存於外接式腫瘤偵測模組1之記憶體內,在此態樣中,外接式腫瘤偵測模組1亦可作為行動硬碟之用。In other embodiments, the external tumor detection module 1 can further include a processing program for determining whether the tissue has a tumor according to the sensing signals, that is, the processing program receives the sensing signals and outputs whether Has the result of a tumor. The processing program can be stored on a CD, a memory or a server. When the user purchases the external tumor detection module 1, it can attach a CD, a USB hard disk, or give a password to download the processing program from the server. In addition, the processing program can also be stored in the memory of the external tumor detecting module 1. In this aspect, the external tumor detecting module 1 can also be used as a mobile hard disk.
另外,由圖9亦可得知,感測訊號皆具有相同之趨勢,例如幾乎同時間下降或上升,這是由於本實施例之發光元件與光感測元件之水平距離係實質相同所造成的。因此,本實施例可簡化分析,並可降低處理程式之成本及其所佔記憶體空間。In addition, as can be seen from FIG. 9, the sensing signals all have the same tendency, for example, falling or rising almost simultaneously, because the horizontal distances of the light-emitting elements and the light-sensing elements of the embodiment are substantially the same. . Therefore, the embodiment can simplify the analysis and reduce the cost of the processing program and the memory space occupied by the processing program.
此外,由圖9亦可知,所有發光元件12所對應的感測訊號之波形皆有相似的趨勢,這也證明本實施例僅需要2個以上之發光元件12即可判斷是否具有腫瘤存在。當然,本實施例之感測訊號可用來分析以得知各個參數(如去氧血紅素、含氧血紅素)之值以利後續分析,例如確認腫瘤之種類。In addition, as can be seen from FIG. 9, the waveforms of the sensing signals corresponding to all of the light-emitting elements 12 have similar trends, which also proves that only two or more light-emitting elements 12 are needed in this embodiment to determine whether or not a tumor exists. Of course, the sensing signals of this embodiment can be used to analyze the values of various parameters (such as deoxyhemoglobin, oxygenated hemoglobin) for subsequent analysis, such as confirming the type of tumor.
當發光元件12與光感測元件13之距離(y)越遠時,發光元件12所發出之光線需經過較長的距離才能到達光感測元件13,而其中可能會增加雜訊干擾及訊號衰減的機會而影響準確度,並可能使得圖9所示之波形下降的時間拉長、下降的幅度較小而不利判斷。並且y越大越不利薄型化。經由驗證,當發光元件12與光感測元件13之距離(y)小於3公分時,可使準確度得到顯著提升結果。When the distance (y) of the light-emitting element 12 from the light-sensing element 13 is farther, the light emitted by the light-emitting element 12 needs to travel a long distance to reach the light-sensing element 13, which may increase noise interference and signal. The chance of attenuation affects the accuracy, and may cause the time of the waveform drop shown in FIG. 9 to be elongated and the magnitude of the decrease is small and unfavorable. And the larger the y, the more disadvantageous the thinning. By verification, when the distance (y) of the light-emitting element 12 from the light-sensing element 13 is less than 3 cm, the accuracy can be significantly improved.
另外,外接式腫瘤偵測模組1亦可具有複數光感測元件13,如圖10所示,其係顯示兩光感測元件13與發光元件12設置的態樣。其中,兩光感測元件13鄰設於該等發光元件12並使該等發光元件12實質位於兩光感測元件13之中心,且兩光感測元件13分別吸收該等繞射光線而對應產生感測訊號。需說明的是,圖10所示之發光元件12係以較誇大之比例繪製,實際上,該等發光元件12係實質位於二光感測元件13之中心範圍。In addition, the external tumor detecting module 1 can also have a plurality of light sensing elements 13, as shown in FIG. 10, which display the two light sensing elements 13 and the light emitting elements 12 disposed. The two light sensing elements 13 are disposed adjacent to the light emitting elements 12 and the light emitting elements 12 are substantially located at the center of the two light sensing elements 13, and the two light sensing elements 13 respectively absorb the diffracted rays. Generate a sensing signal. It should be noted that the light-emitting elements 12 shown in FIG. 10 are drawn at a relatively large scale. In fact, the light-emitting elements 12 are substantially located in the center of the two-photosensitive sensing element 13.
當使用者使用具有兩光感測元件13之外接式腫瘤偵測模組1掃描腫瘤組織時,其中一光感測元件13會先接收到發光元件12所發出且經過腫瘤之光線,其感測訊號波形可例如圖11A所示,然後使用者持續掃描時,另一光感測元件13亦會接收到發光元件12所發出且經過腫瘤之光線,其感測訊號波形可例如圖11B所示。由圖11A及圖11B可知,兩者之波形下降的時間點存在一時間差,這是因為光感測元件13設置於發光元件12兩側的原因。藉由圖11A與圖11B的波形可更加準確地判斷腫瘤存在與否及腫瘤位置。When the user scans the tumor tissue using the external tumor detecting module 1 having the two light sensing elements 13, one of the light sensing elements 13 first receives the light emitted by the light emitting element 12 and passes through the tumor, and the sensing thereof The signal waveform can be, for example, as shown in FIG. 11A. When the user continues to scan, the other light sensing element 13 also receives the light emitted by the light-emitting element 12 and passes through the tumor. The sensing signal waveform can be, for example, as shown in FIG. 11B. As can be seen from FIG. 11A and FIG. 11B, there is a time difference at the time point when the waveforms of the two are lowered, because the light sensing elements 13 are disposed on both sides of the light-emitting element 12. The presence or absence of the tumor and the location of the tumor can be more accurately determined by the waveforms of FIGS. 11A and 11B.
此外,本實施例之處理程式係可使兩光感測元件13所產生之該等感測訊號建立一函數關係而對應產生複數處理訊號,並依據該等處理訊號決定組織是否具有腫瘤。於此,處理訊號之波形如圖12所示,本實施例之處理訊號係藉由圖11A與圖11B之感測訊號建立一函數關係而產生,且各處理訊號係由該等光感測元件13接收同一發光元件發出之光線所產生之感測訊號來產生。需先說明,假設圖11A所示之波形係藉由設置於發光元件之左側(L)的光感測元件13所產生,而圖11B所示之波形係藉由設置於發光元件之右側(R)的光感測元件13所產生。這樣,圖12所示之波形係由log(L)-log(R)所形成。如此,當圖12所示之橢圓虛線區域出現時,即證明腫瘤存在並得知腫瘤位置。在實施上,當處理程式分析到橢圓虛線區域時,電子裝置E或外接式腫瘤偵測模組1可發出嗶嗶聲提醒使用者,而這時腫瘤之位置即在發光元件12附近。In addition, the processing program of the embodiment can establish a functional relationship between the sensing signals generated by the two light sensing elements 13 to generate a complex processing signal, and determine whether the tissue has a tumor according to the processing signals. The waveform of the processing signal is as shown in FIG. 12, and the processing signal of the embodiment is generated by establishing a function relationship between the sensing signals of FIG. 11A and FIG. 11B, and each processing signal is generated by the optical sensing components. 13 is generated by receiving a sensing signal generated by light emitted by the same light-emitting element. It should be noted that the waveform shown in FIG. 11A is generated by the light sensing element 13 disposed on the left side (L) of the light emitting element, and the waveform shown in FIG. 11B is disposed on the right side of the light emitting element (R). The light sensing element 13 is produced. Thus, the waveform shown in Fig. 12 is formed by log(L)-log(R). Thus, when the elliptical dotted line area shown in Fig. 12 appears, it is confirmed that the tumor exists and the tumor position is known. In practice, when the processing program analyzes the elliptical dotted line area, the electronic device E or the external tumor detecting module 1 can beep to remind the user, and the position of the tumor is near the light emitting element 12.
另外,外接式腫瘤偵測模組1亦可具有數量大於2之光感測元件13,如圖13所示,其係顯示四光感測元件13與發光元件12設置的態樣。其中,該等光感測元件13鄰設於該等發光元件12並使該等發光元件12實質位於四光感測元件13之中心,且四光感測元件13分別吸收該等繞射光線而對應產生感測訊號。其中,各光感測元件13所產生之感測訊號可參照圖11A、圖11B及圖12,於此不再贅述。In addition, the external tumor detecting module 1 can also have a number of light sensing elements 13 greater than 2, as shown in FIG. 13, which shows the arrangement of the four light sensing elements 13 and the light emitting elements 12. The light sensing elements 13 are disposed adjacent to the light emitting elements 12 and the light emitting elements 12 are substantially located at the center of the four light sensing elements 13, and the four light sensing elements 13 respectively absorb the diffracted rays. Corresponding to generate a sensing signal. The sensing signals generated by the optical sensing elements 13 can be referred to FIG. 11A, FIG. 11B and FIG. 12, and details are not described herein again.
以下舉例說明圖13之態樣用於腫瘤偵測所會遇到的情況。如圖14A所示,腫瘤T係位於發光元件12與光感測元件13a之間,此時,光感測元件13a之訊號強度係小於光感測元件13b之訊號強度,而光感測元件13c之訊號強度係等於光感測元件13d之訊號強度,如此,處理模組係可判斷決定腫瘤之位置係位於發光元件12與光感測元件13a之間。The following is an example of the situation in Figure 13 for tumor detection. As shown in FIG. 14A, the tumor T is located between the light-emitting element 12 and the light-sensing element 13a. At this time, the signal intensity of the light-sensing element 13a is smaller than the signal intensity of the light-sensing element 13b, and the light-sensing element 13c The signal intensity is equal to the signal intensity of the light sensing element 13d. Thus, the processing module can determine that the position of the tumor is located between the light emitting element 12 and the light sensing element 13a.
如圖14B所示,腫瘤T係位於發光元件12與光感測元件13c之間,此時,光感測元件13c之訊號強度係小於光感測元件13d之訊號強度,而光感測元件13a之訊號強度係等於光感測元件13b之訊號強度,如此,處理模組係可判斷決定腫瘤之位置係位於發光元件12與光感測元件13c之間。As shown in FIG. 14B, the tumor T is located between the light-emitting element 12 and the light-sensing element 13c. At this time, the signal intensity of the light-sensing element 13c is smaller than the signal intensity of the light-sensing element 13d, and the light-sensing element 13a The signal intensity is equal to the signal intensity of the light sensing element 13b. Thus, the processing module can determine that the position of the tumor is located between the light emitting element 12 and the light sensing element 13c.
如圖14C所示,腫瘤T係位於發光元件12與光感測元件13c與光感測元件13a之間,此時,光感測元件13c之訊號強度係小於光感測元件13d之訊號強度,而光感測元件13a之訊號強度係小於光感測元件13b之訊號強度,如此,處理模組係可判斷決定腫瘤之位置係位於發光元件12與光感測元件13c與光感測元件13a之間。As shown in FIG. 14C, the tumor T is located between the light-emitting element 12 and the light-sensing element 13c and the light-sensing element 13a. At this time, the signal intensity of the light-sensing element 13c is smaller than the signal intensity of the light-sensing element 13d. The signal intensity of the light sensing component 13a is smaller than the signal intensity of the light sensing component 13b. Thus, the processing module can determine that the position of the tumor is located in the light emitting component 12 and the light sensing component 13c and the light sensing component 13a. between.
藉由上述機制可得到腫瘤之位置以達到腫瘤定位功能,而在定位的過程中,處理程式可加入即時導引功能,例如當處理程式決定該組織具有腫瘤時,電子裝置E或外接式腫瘤偵測模組1可發出一提示以指明具有腫瘤或腫瘤之方位。Through the above mechanism, the position of the tumor can be obtained to achieve the tumor localization function, and in the process of positioning, the processing program can be added to the immediate guidance function, for example, when the processing program determines that the tissue has a tumor, the electronic device E or the external tumor detection The test module 1 can issue a prompt to indicate the location of the tumor or tumor.
另外,上述6個感測訊號除了可用來比較訊號強度以判斷腫瘤及其位置之外,感測訊號亦可利用公式來計算出去氧血紅素、含氧血紅素、水、脂肪之組織成分並與資料庫之資料進行比對以準確得知腫瘤之存在及其類型。而前述其中一發光元件12(於此係以690nm為例)係可作為膚色校正,其校正方法可有二種,一種係藉由處理程式將用於膚色校正之感測訊號帶入公式以求得校正過之去氧血紅素、含氧血紅素、水、脂肪之成分。另一種係藉由處理程式利用找查表(look-up table)方式,其找查表之示意可例如下表所示:In addition, the above six sensing signals can be used to compare the signal strength to determine the tumor and its position, and the sensing signal can also use the formula to calculate the tissue components of the oxygen hemoglobin, the oxygenated hemoglobin, the water, and the fat. The data in the database were compared to accurately understand the presence and type of the tumor. The above-mentioned one of the light-emitting elements 12 (herein, 690 nm is taken as an example) can be used as a skin color correction, and there are two methods for correcting the same. One is to introduce a sensing signal for skin color correction into a formula by a processing program. Corrected components of deoxyhemoglobin, oxygenated hemoglobin, water, and fat. The other method uses a look-up table by means of a processing program, and the indication of the lookup table can be as shown in the following table:
其中,若用於膚色校正之感測訊號的強度(例如平均強度)分別為A1 、A2 、A3 、A4 ,所對應之去氧血紅素、含氧血紅素、水、脂肪各有其校正值δ11 …以供校正。Wherein, if the intensity of the sensing signal used for skin color correction (for example, the average intensity) is A 1 , A 2 , A 3 , A 4 , respectively, the corresponding deoxyhemoglobin, oxygenated hemoglobin, water, and fat have Its correction value δ 11 ... is corrected.
另外,本實施例為防止外界光線的干擾,外接式腫瘤偵測模組1可具有一暗電流操作模式。當外接式腫瘤偵測模組1位於暗電流操作模式時,該等發光元件12係不發光,而光感測元件13係感測一環境光線而產生一環境感測訊號,且環境感測訊號傳送至電子裝置E,使處理程式藉由環境感測訊號校正該等感測訊號。需注意的是,當使用者使用暗電流操作模式時,使用者可將外接式腫瘤偵測模組1靠近身體以提高環境感測訊號之準確度。In addition, in the embodiment, in order to prevent interference of external light, the external tumor detecting module 1 may have a dark current operation mode. When the external tumor detecting module 1 is in the dark current operation mode, the light emitting elements 12 are not illuminated, and the light sensing element 13 senses an ambient light to generate an environmental sensing signal, and the ambient sensing signal The device transmits to the electronic device E, so that the processing program corrects the sensing signals by the environmental sensing signal. It should be noted that when the user uses the dark current operation mode, the user can bring the external tumor detection module 1 close to the body to improve the accuracy of the environmental sensing signal.
本實施例之環境感測訊號例如圖11A及圖11B所示之標號為「dark」之曲線,由於本實施例係在一較暗的空間內實施,故環境感測訊號之訊號強度接近0。環境感測訊號之校正方法可藉由公式或找查表,其中,公式可例如藉由該等感測訊號扣除環境感測訊號,找查表可仿照上述膚色校正找查表,於此不再贅述。需注意的是,環境感測訊號不僅反應環境光線,也同時反應光感測元件自身訊號的干擾。The environmental sensing signal of the present embodiment has a curve labeled "dark" as shown in FIG. 11A and FIG. 11B. Since the embodiment is implemented in a dark space, the signal intensity of the environmental sensing signal is close to zero. The calibration method of the environmental sensing signal can be obtained by using a formula or a look-up table, wherein the formula can deduct the environmental sensing signal by using the sensing signals, for example, the look-up table can be modeled after the skin color correction check table, and no longer Narration. It should be noted that the environmental sensing signal not only reflects the ambient light, but also reflects the interference of the light sensing component's own signal.
綜上所述,本發明揭露一種外接式腫瘤偵測模組,這裡的外接式係指例如藉由連接器而與一電子裝置連結、或與一電子裝置進行無線通訊。藉此,使用者若需要不定期偵測身體組織是否正常,可購買外接式腫瘤偵測模組,並與一電子裝置,例如手機或PDA連結,即可進行偵測,或是購買外接式腫瘤偵測模組,其可與電子裝置進行無線通訊,例如藉由藍芽技術,可將偵測結果傳送至電子裝置進行處理,以得到偵測結果,甚至還可進行個人歷史資料的儲存。藉此,本發明之外接式腫瘤偵測模組有助於使用者自行檢測以達到預防或提早發現之效果,且非常方便使用,這大大提高使用者自行檢測的意願。In summary, the present invention discloses an external tumor detection module, wherein the external connection refers to connection with an electronic device or wireless communication with an electronic device, for example, by a connector. In this way, if the user needs to detect the normality of the body tissue from time to time, the user can purchase an external tumor detection module and connect with an electronic device such as a mobile phone or a PDA to detect or purchase an external tumor. The detection module can communicate wirelessly with the electronic device. For example, through the Bluetooth technology, the detection result can be transmitted to the electronic device for processing to obtain the detection result, and even the personal history data can be stored. Therefore, the external tumor detection module of the invention can help the user to detect by itself to achieve the effect of prevention or early detection, and is very convenient to use, which greatly improves the user's willingness to detect by himself.
此外,發光元件輪流發出一光線(例如近紅外線)經由組織繞射,再被光感測元件吸收而產生感測訊號,由於病變組織與正常組織之含氧血基血溶素及去氧血基血溶素之比例不同,故當光線經過正常組織與病變組織時,兩者對光線吸收的程度亦不同,使得近紅外線光譜經由組織繞射而收回之訊號強度有所差異。如此,藉由處理單元之處理即可判斷組織是否具有腫瘤或癌細胞等病變組織。In addition, the illuminating element emits a light (for example, near-infrared rays) in turn through the tissue, and is absorbed by the light sensing element to generate a sensing signal, due to the oxygenated blood-based blood lysin and deoxygenated blood base of the diseased tissue and the normal tissue. The ratio of blood lysin is different, so when the light passes through the normal tissue and the diseased tissue, the degree of light absorption is different, so that the signal intensity of the near-infrared spectrum recovered by the tissue diffraction is different. In this way, it is possible to determine whether the tissue has a diseased tissue such as a tumor or a cancer cell by the processing of the processing unit.
此外,本發明藉由x與y滿足x0.1*y之關係式,而限制各發光元件與光感測元件之水平距離實質相同,使得光感測元件係在相同的基準線接收來自各發光元件所發出之光線,進而簡化分析,並可降低處理程式之成本。Furthermore, the present invention satisfies x by x and y a relationship of 0.1*y, and limiting the horizontal distance between each of the light-emitting elements and the light-sensing element is substantially the same, so that the light-sensing elements receive light from the respective light-emitting elements on the same reference line, thereby simplifying analysis and Reduce the cost of the processing program.
此外,其中一發光元件所發出之光線係作為膚色校正,可提高腫瘤判斷之準確度。In addition, the light emitted by one of the light-emitting elements is corrected as a skin color, which improves the accuracy of tumor determination.
此外,複數光感測元件設置於該等發光元件之中心範圍,該等光感測元件之感測訊號可進一步作為腫瘤判斷之依據而提高準確度,且該等光感測元件設置於該等發光元件之中心範圍亦簡化訊號處理過程。In addition, the plurality of light sensing elements are disposed at a central range of the light emitting elements, and the sensing signals of the light sensing elements can further improve the accuracy as a basis for determining the tumor, and the light sensing elements are disposed on the light sensing elements. The central range of the illuminating elements also simplifies the signal processing.
以上所述僅為舉例性,而非為限制性者。任何未脫離本發明之精神與範疇,而對其進行之等效修改或變更,均應包含於後附之申請專利範圍中。The above is intended to be illustrative only and not limiting. Any equivalent modifications or alterations to the spirit and scope of the invention are intended to be included in the scope of the appended claims.
1...外接式腫瘤偵測模組1. . . External tumor detection module
11...處理單元11. . . Processing unit
12...發光元件12. . . Light-emitting element
13、13a~13d...光感測元件13, 13a ~ 13d. . . Light sensing component
14...訊號傳輸單元14. . . Signal transmission unit
15...濾光片15. . . Filter
16...供電單元16. . . Power supply unit
17...控制鈕17. . . Control button
18...殼體18. . . case
E...電子裝置E. . . Electronic device
T...腫瘤T. . . Tumor
圖1為本發明較佳實施例之一種外接式腫瘤偵測模組的外觀示意圖;1 is a schematic diagram of the appearance of an external tumor detecting module according to a preferred embodiment of the present invention;
圖2為外接式腫瘤偵測模組的方塊示意圖;2 is a block diagram of an external tumor detecting module;
圖3及圖4為外接式腫瘤偵測模組與一電子裝置配合使用的示意圖;3 and 4 are schematic diagrams showing the use of an external tumor detecting module in conjunction with an electronic device;
圖5為外接式腫瘤偵測模組的俯視放大示意圖;FIG. 5 is a schematic enlarged plan view of the external tumor detecting module; FIG.
圖6及圖7係為發光元件發射光線,光線經由組織內繞射,並穿出而由光感測元件接收的示意圖;6 and FIG. 7 are schematic diagrams showing that the light-emitting element emits light, the light is diffracted through the tissue, and is received by the light-sensing element;
圖8係為使用者握持外接式腫瘤偵測模組進行偵測的操作示意圖;FIG. 8 is a schematic diagram of the operation of the user holding the external tumor detecting module for detecting;
圖9係為感測訊號的波形示意圖;9 is a waveform diagram of a sensing signal;
圖10係為兩光感測元件與發光元件的設置示意圖;Figure 10 is a schematic view showing the arrangement of two light sensing elements and light emitting elements;
圖11A及圖11B係分別為圖10之兩光感測元件所感測之感測訊號的波形示意圖;11A and FIG. 11B are waveform diagrams of sensing signals sensed by the two photo sensing elements of FIG. 10;
圖12係為處理訊號的波形示意圖;Figure 12 is a waveform diagram of processing signals;
圖13係為四光感測元件與發光元件的設置示意圖;以及Figure 13 is a schematic view showing the arrangement of four light sensing elements and light emitting elements;
圖14A至圖14C係圖13之態樣用於腫瘤偵測的示意圖。14A to 14C are schematic views of the aspect of Fig. 13 for tumor detection.
1...外接式腫瘤偵測模組1. . . External tumor detection module
11...處理單元11. . . Processing unit
12...發光元件12. . . Light-emitting element
13...光感測元件13. . . Light sensing component
14...訊號傳輸單元14. . . Signal transmission unit
15...濾光片15. . . Filter
17...控制鈕17. . . Control button
18...殼體18. . . case
Claims (13)
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